KEGG   PATHWAY: mmu04148
Entry
mmu04148                    Pathway                                
Name
Efferocytosis - Mus musculus (house mouse)
Class
Cellular Processes; Transport and catabolism
Pathway map
mmu04148  Efferocytosis
mmu04148

Organism
Mus musculus (house mouse) [GN:mmu]
Gene
12367  Casp3; caspase 3 [KO:K02187] [EC:3.4.22.56]
12369  Casp7; caspase 7 [KO:K04397] [EC:3.4.22.60]
12362  Casp1; caspase 1 [KO:K01370] [EC:3.4.22.36]
55991  Panx1; pannexin 1 [KO:K03443]
18442  P2ry2; purinergic receptor P2Y, G-protein coupled 2 [KO:K04269]
233571  P2ry6; pyrimidinergic receptor P2Y, G-protein coupled, 6 [KO:K04272]
70839  P2ry12; purinergic receptor P2Y, G-protein coupled 12 [KO:K04298]
56632  Sphk2; sphingosine kinase 2 [KO:K04718] [EC:2.7.1.91]
20698  Sphk1; sphingosine kinase 1 [KO:K04718] [EC:2.7.1.91]
13609  S1pr1; sphingosine-1-phosphate receptor 1 [KO:K04288]
53357  Pla2g6; phospholipase A2, group VI [KO:K16343] [EC:3.1.1.4]
11303  Abca1; ATP-binding cassette, sub-family A member 1 [KO:K05641]
56696  Gpr132; G protein-coupled receptor 132 [KO:K08426]
11491  Adam17; a disintegrin and metallopeptidase domain 17 [KO:K06059] [EC:3.4.24.86]
11487  Adam10; a disintegrin and metallopeptidase domain 10 [KO:K06704] [EC:3.4.24.81]
20312  Cx3cl1; C-X3-C motif chemokine ligand 1 [KO:K05508]
13051  Cx3cr1; C-X3-C motif chemokine receptor 1 [KO:K04192]
18019  Nfatc2; nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 2 [KO:K17332]
18018  Nfatc1; nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 1 [KO:K04446]
18021  Nfatc3; nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 3 [KO:K17333]
73181  Nfatc4; nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 4 [KO:K17334]
15251  Hif1a; hypoxia inducible factor 1, alpha subunit [KO:K08268]
11863  Arnt; aryl hydrocarbon receptor nuclear translocator [KO:K09097]
13856  Epo; erythropoietin [KO:K05437]
13857  Epor; erythropoietin receptor [KO:K05079]
16452  Jak2; Janus kinase 2 [KO:K04447] [EC:2.7.10.2]
26413  Mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
26417  Mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
12608  Cebpb; CCAAT/enhancer binding protein beta [KO:K10048]
19016  Pparg; peroxisome proliferator activated receptor gamma [KO:K08530]
20181  Rxra; retinoid X receptor alpha [KO:K08524]
17304  Mfge8; milk fat globule EGF and factor V/VIII domain containing [KO:K17253]
14456  Gas6; growth arrest specific 6 [KO:K05464]
17289  Mertk; MER proto-oncogene tyrosine kinase [KO:K05117] [EC:2.7.10.1]
12491  Cd36; CD36 molecule [KO:K06259]
21825  Thbs1; thrombospondin 1 [KO:K16857]
26395  Map2k1; mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
26396  Map2k2; mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
19225  Ptgs2; prostaglandin-endoperoxide synthase 2 [KO:K11987] [EC:1.14.99.1]
19217  Ptger2; prostaglandin E receptor 2 (subtype EP2) [KO:K04259]
19219  Ptger4; prostaglandin E receptor 4 (subtype EP4) [KO:K04261]
13435  Dnmt3a; DNA methyltransferase 3A [KO:K17398] [EC:2.1.1.37]
12912  Creb1; cAMP responsive element binding protein 1 [KO:K05870]
21803  Tgfb1; transforming growth factor, beta 1 [KO:K13375]
11937  Atp2a1; ATPase, Ca++ transporting, cardiac muscle, fast twitch 1 [KO:K05853] [EC:7.2.2.10]
53313  Atp2a3; ATPase, Ca++ transporting, ubiquitous [KO:K05853] [EC:7.2.2.10]
11938  Atp2a2; ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 [KO:K05853] [EC:7.2.2.10]
108058  Camk2d; calcium/calmodulin-dependent protein kinase II, delta [KO:K04515] [EC:2.7.11.17]
12325  Camk2g; calcium/calmodulin-dependent protein kinase II gamma [KO:K04515] [EC:2.7.11.17]
12323  Camk2b; calcium/calmodulin-dependent protein kinase II, beta [KO:K04515] [EC:2.7.11.17]
12322  Camk2a; calcium/calmodulin-dependent protein kinase II alpha [KO:K04515] [EC:2.7.11.17]
26416  Mapk14; mitogen-activated protein kinase 14 [KO:K04441] [EC:2.7.11.24]
19094  Mapk11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
29857  Mapk12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
26415  Mapk13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
17164  Mapkapk2; MAP kinase-activated protein kinase 2 [KO:K04443] [EC:2.7.11.1]
11689  Alox5; arachidonate 5-lipoxygenase [KO:K00461] [EC:1.13.11.34]
11687  Alox15; arachidonate 15-lipoxygenase [KO:K00460] [EC:1.13.11.33]
319520  Dusp4; dual specificity phosphatase 4 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
235584  Dusp7; dual specificity phosphatase 7 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
18218  Dusp8; dual specificity phosphatase 8 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
240672  Dusp5; dual specificity phosphatase 5 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
13537  Dusp2; dual specificity phosphatase 2 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
70686  Dusp16; dual specificity phosphatase 16 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
105722  Ano6; anoctamin 6 [KO:K19500]
228432  Ano3; anoctamin 3 [KO:K19498]
320091  Ano4; anoctamin 4 [KO:K19499]
233246  Ano5; anoctamin 5 [KO:K19480]
404545  Ano7; anoctamin 7 [KO:K19501]
71345  Ano9; anoctamin 9 [KO:K19503]
12215  Bsg; basigin [KO:K06535]
381560  Xkr8; X-linked Kx blood group related 8 [KO:K26813]
381246  Xkr9; X-linked Kx blood group related 9 [KO:K26814]
228787  Xkr7; X-linked Kx blood group related 7 [KO:K26811]
497097  Xkr4; X-linked Kx blood group related 4 [KO:K26811]
219149  Xkr6; X-linked Kx blood group related 6 [KO:K26811]
11980  Atp8a1; ATPase phospholipid transporting 8A1 [KO:K14802] [EC:7.6.2.1]
50769  Atp8a2; ATPase, aminophospholipid transporter-like, class I, type 8A, member 2 [KO:K14802] [EC:7.6.2.1]
320940  Atp11c; ATPase, class VI, type 11C [KO:K26934] [EC:7.6.2.1]
50770  Atp11a; ATPase, class VI, type 11A [KO:K26934] [EC:7.6.2.1]
76295  Atp11b; ATPase, class VI, type 11B [KO:K26934] [EC:7.6.2.1]
69981  Tmem30a; transmembrane protein 30A [KO:K26935]
19128  Pros1; protein S (alpha) [KO:K03908]
16410  Itgav; integrin alpha V [KO:K06487]
16416  Itgb3; integrin beta 3 [KO:K06493]
16419  Itgb5; integrin beta 5 [KO:K06588]
26362  Axl; AXL receptor tyrosine kinase [KO:K05115] [EC:2.7.10.1]
22174  Tyro3; TYRO3 protein tyrosine kinase 3 [KO:K05116] [EC:2.7.10.1]
107831  Adgrb1; adhesion G protein-coupled receptor B1 [KO:K04596]
276891  Timd4; T cell immunoglobulin and mucin domain containing 4 [KO:K26936]
171283  Havcr1; hepatitis A virus cellular receptor 1 [KO:K20413]
171284  Timd2; T cell immunoglobulin and mucin domain containing 2 [KO:K20413]
171285  Havcr2; hepatitis A virus cellular receptor 2 [KO:K20414]
11596  Ager; advanced glycosylation end product-specific receptor [KO:K19722]
192187  Stab1; stabilin 1 [KO:K19020]
192188  Stab2; stabilin 2 [KO:K19013]
14083  Ptk2; PTK2 protein tyrosine kinase 2 [KO:K05725] [EC:2.7.10.2]
12927  Bcar1; breast cancer anti-estrogen resistance 1 [KO:K05726]
12928  Crk; v-crk avian sarcoma virus CT10 oncogene homolog [KO:K04438]
12929  Crkl; v-crk avian sarcoma virus CT10 oncogene homolog-like [KO:K04438]
140580  Elmo1; engulfment and cell motility 1 [KO:K12366]
330662  Dock1; dedicator of cytokinesis 1 [KO:K13708]
19353  Rac1; Rac family small GTPase 1 [KO:K04392]
11502  Adam9; ADAM metallopeptidase domain 9 [KO:K06834] [EC:3.4.24.-]
12317  Calr; calreticulin [KO:K08057]
108802  Calr4; calreticulin 4 [KO:K08057]
12259  C1qa; complement component 1, q subcomponent, alpha polypeptide [KO:K03986]
12260  C1qb; complement component 1, q subcomponent, beta polypeptide [KO:K03987]
12262  C1qc; complement component 1, q subcomponent, C chain [KO:K03988]
16971  Lrp1; low density lipoprotein receptor-related protein 1 [KO:K04550]
70417  Megf10; multiple EGF-like-domains 10 [KO:K24068]
214058  Megf11; multiple EGF-like-domains 11 [KO:K24068]
380713  Scarf1; scavenger receptor class F, member 1 [KO:K24318]
70676  Gulp1; GULP, engulfment adaptor PTB domain containing 1 [KO:K23285]
19329  Rab17; RAB17, member RAS oncogene family [KO:K07909]
271457  Rab5a; RAB5A, member RAS oncogene family [KO:K07887]
19344  Rab5b; RAB5B, member RAS oncogene family [KO:K07888]
19345  Rab5c; RAB5C, member RAS oncogene family [KO:K07889]
73122  Tgfbrap1; transforming growth factor, beta receptor associated protein 1 [KO:K20177]
209018  Vps8; VPS8 CORVET complex subunit [KO:K20178]
71732  Vps11; VPS11, CORVET/HOPS core subunit [KO:K20179]
80743  Vps16; VSP16 CORVET/HOPS core subunit [KO:K20180]
228545  Vps18; VPS18 CORVET/HOPS core subunit [KO:K20181]
77573  Vps33a; VPS33A CORVET/HOPS core subunit [KO:K20182]
68365  Rab14; RAB14, member RAS oncogene family [KO:K07881]
269338  Vps39; VPS39 HOPS complex subunit [KO:K20183]
218035  Vps41; VPS41 HOPS complex subunit [KO:K20184]
19349  Rab7; RAB7, member RAS oncogene family [KO:K07897]
226421  Rab7b; RAB7B, member RAS oncogene family [KO:K07898]
212555  Slc66a1; solute carrier family 66 member 1 [KO:K23678]
11846  Arg1; arginase, liver [KO:K01476] [EC:3.5.3.1]
11847  Arg2; arginase type II [KO:K01476] [EC:3.5.3.1]
18263  Odc1; ornithine decarboxylase, structural 1 [KO:K01581] [EC:4.1.1.17]
332942  Ldc1; leucine decarboxylase 1 [KO:K01581] [EC:4.1.1.17]
12642  Ch25h; cholesterol 25-hydroxylase [KO:K10223] [EC:1.14.99.38]
22259  Nr1h3; nuclear receptor subfamily 1, group H, member 3 [KO:K08536]
22260  Nr1h2; nuclear receptor subfamily 1, group H, member 2 [KO:K08535]
12894  Cpt1a; carnitine palmitoyltransferase 1a, liver [KO:K08765] [EC:2.3.1.21]
12895  Cpt1b; carnitine palmitoyltransferase 1b, muscle [KO:K19523] [EC:2.3.1.21]
78070  Cpt1c; carnitine palmitoyltransferase 1c [KO:K19524] [EC:2.3.1.21]
66694  Uqcrfs1; ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1 [KO:K00411] [EC:7.1.1.8]
93759  Sirt1; sirtuin 1 [KO:K11411] [EC:2.3.1.286]
18514  Pbx1; pre B cell leukemia homeobox 1 [KO:K09355]
16153  Il10; interleukin 10 [KO:K05443]
16889  Lipa; lysosomal acid lipase A [KO:K01052] [EC:3.1.1.13]
192654  Pla2g15; phospholipase A2, group XV [KO:K06129] [EC:3.1.1.5]
19015  Ppard; peroxisome proliferator activator receptor delta [KO:K04504]
20525  Slc2a1; solute carrier family 2 (facilitated glucose transporter), member 1 [KO:K07299]
20501  Slc16a1; solute carrier family 16 (monocarboxylic acid transporters), member 1 [KO:K08179]
20393  Sgk1; serum/glucocorticoid regulated kinase 1 [KO:K13302] [EC:2.7.11.1]
16423  Cd47; CD47 antigen (Rh-related antigen, integrin-associated signal transducer) [KO:K06266]
12484  Cd24a; CD24a antigen [KO:K06469]
18613  Pecam1; platelet/endothelial cell adhesion molecule 1 [KO:K06471]
243958  Siglecg; sialic acid binding Ig-like lectin G [KO:K06749]
19261  Sirpa; signal-regulatory protein alpha [KO:K06551]
668101  Sirpb1b; signal-regulatory protein beta 1B [KO:K06551]
100038947  Sirpb1c; signal-regulatory protein beta 1C [KO:K06551]
751864  Sirpd; signal regulatory protein delta [KO:K06551]
320832  Sirpb1a; signal-regulatory protein beta 1A [KO:K06551]
15170  Ptpn6; protein tyrosine phosphatase, non-receptor type 6 [KO:K05697] [EC:3.1.3.48]
19247  Ptpn11; protein tyrosine phosphatase, non-receptor type 11 [KO:K07293] [EC:3.1.3.48]
Compound
C00002  ATP
C00003  NAD+
C00019  S-Adenosyl-L-methionine
C00031  D-Glucose
C00062  L-Arginine
C00073  L-Methionine
C00075  UTP
C00077  L-Ornithine
C00134  Putrescine
C00162  Fatty acid
C00186  (S)-Lactate
C00187  Cholesterol
C00584  Prostaglandin E2
C02530  Cholesterol ester
C02737  Phosphatidylserine
C04230  1-Acyl-sn-glycero-3-phosphocholine
C06124  Sphingosine 1-phosphate
C06314  Lipoxin A4
C15519  25-Hydroxycholesterol
C15610  Cholest-5-ene-3beta,26-diol
C18178  Resolvin D1
Reference
PMID:31822793
  Authors
Doran AC, Yurdagul A Jr, Tabas I
  Title
Efferocytosis in health and disease.
  Journal
Nat Rev Immunol 20:254-267 (2020)
DOI:10.1038/s41577-019-0240-6
Reference
PMID:36028471
  Authors
Zhang J, Ding W, Zhao M, Liu J, Xu Y, Wan J, Wang M
  Title
Mechanisms of efferocytosis in determining inflammation resolution: Therapeutic potential and the association with cardiovascular disease.
  Journal
Br J Pharmacol 179:5151-5171 (2022)
DOI:10.1111/bph.15939
Reference
PMID:30165442
  Authors
Kawano M, Nagata S
  Title
Efferocytosis and autoimmune disease.
  Journal
Int Immunol 30:551-558 (2018)
DOI:10.1093/intimm/dxy055
Reference
PMID:35650427
  Authors
Mehrotra P, Ravichandran KS
  Title
Drugging the efferocytosis process: concepts and opportunities.
  Journal
Nat Rev Drug Discov 21:601-620 (2022)
DOI:10.1038/s41573-022-00470-y
Reference
PMID:28496201
  Authors
Park SY, Kim IS
  Title
Engulfment signals and the phagocytic machinery for apoptotic cell clearance.
  Journal
Exp Mol Med 49:e331 (2017)
DOI:10.1038/emm.2017.52
Reference
PMID:28137963
  Authors
Kojima Y, Weissman IL, Leeper NJ
  Title
The Role of Efferocytosis in Atherosclerosis.
  Journal
Circulation 135:476-489 (2017)
DOI:10.1161/CIRCULATIONAHA.116.025684
Related
pathway
mmu00010  Glycolysis / Gluconeogenesis
mmu04140  Autophagy - animal
mmu04145  Phagosome
KO pathway
ko04148   
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