KEGG   PATHWAY: mmur05160
Entry
mmur05160                   Pathway                                
Name
Hepatitis C - Microcebus murinus (gray mouse lemur)
Description
Hepatitis C virus (HCV) is a major cause of chronic liver disease. The HCV employ several strategies to perturb host cell immunity. After invasion, HCV RNA genome functions directly as an mRNA in the cytoplasm of the host cell and forms membrane-associated replication complexes along with non-structural proteins. Viral RNA can trigger the RIG-I pathway and interferon production during this process. Translated HCV protein products regulate immune response to inhibit the action of interferon. HCV core and NS5A proteins appear to be the most important molecules with regulatory functions that modulate transcription, cellular proliferation, and apoptosis.
Class
Human Diseases; Infectious disease: viral
Pathway map
mmur05160  Hepatitis C
mmur05160

Organism
Microcebus murinus (gray mouse lemur) [GN:mmur]
Gene
105885441  LDLR; LOW QUALITY PROTEIN: low-density lipoprotein receptor [KO:K12473]
105880850  SCARB1; scavenger receptor class B member 1 isoform X1 [KO:K13885]
105867517  CD81; CD81 antigen [KO:K06508]
105879387  CLDN12; claudin-12 [KO:K06087]
105881301  CLDN14; claudin-14 [KO:K06087]
105859629  CLDN6; claudin-6 [KO:K06087]
105859635  CLDN9; claudin-9 [KO:K06087]
105874157  CLDN10; claudin-10 isoform X1 [KO:K06087]
105882516  claudin-22 [KO:K06087]
105882517  putative claudin-24 [KO:K06087]
105860448  CLDN1; claudin-1 [KO:K06087]
105860449  CLDN16; LOW QUALITY PROTEIN: claudin-16 [KO:K06087]
105868399  CLDN15; claudin-15 isoform X1 [KO:K06087]
105868586  CLDN20; claudin-20 [KO:K06087]
105884056  CLDN18; claudin-18 [KO:K06087]
105862271  CLDN19; claudin-19 [KO:K06087]
105863674  CLDN2; claudin-2 [KO:K06087]
105877736  CLDN5; claudin-5 [KO:K06087]
105877892  CLDN7; claudin-7 [KO:K06087]
105885998  claudin-34-like isoform X1 [KO:K06087]
109730209  CLDN34; claudin-34 [KO:K06087]
105857439  CLDN23; claudin-23 [KO:K06087]
105865022  CLDN25; putative claudin-25 [KO:K06087]
105879192  CLDN11; claudin-11 [KO:K06087]
105880100  CLDN17; claudin-17 [KO:K06087]
105880130  CLDN8; claudin-8 [KO:K06087]
105858844  CLDN3; claudin-3 [KO:K06087]
105858854  CLDN4; claudin-4 [KO:K06087]
105881455  OCLN; occludin [KO:K06088]
105866765  OAS3; 2'-5'-oligoadenylate synthase 3 isoform X1 [KO:K14216] [EC:2.7.7.84]
105866766  OAS2; 2'-5'-oligoadenylate synthase 2 [KO:K14216] [EC:2.7.7.84]
105866767  OAS1; 2'-5'-oligoadenylate synthase 1 isoform X1 [KO:K14216] [EC:2.7.7.84]
105854989  RNASEL; 2-5A-dependent ribonuclease isoform X1 [KO:K01165]
105871184  DDX58; probable ATP-dependent RNA helicase DDX58 isoform X1 [KO:K12646] [EC:5.6.2.6]
105866005  MAVS; mitochondrial antiviral-signaling protein isoform X1 [KO:K12648]
105859313  TNF receptor-associated factor 3-like [KO:K03174]
105861087  TRAF3; TNF receptor-associated factor 3 isoform X1 [KO:K03174]
105880966  TBK1; serine/threonine-protein kinase TBK1 isoform X1 [KO:K05410] [EC:2.7.11.10]
105868963  IKBKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X1 [KO:K07211] [EC:2.7.11.10]
105865644  IRF3; interferon regulatory factor 3 isoform X1 [KO:K05411]
105874038  IRF7; interferon regulatory factor 7 isoform X1 [KO:K09447]
105874211  interferon alpha-10-like [KO:K05414]
105874212  interferon alpha-10-like [KO:K05414]
105874214  interferon alpha-4-like [KO:K05414]
105874217  interferon alpha-10-like [KO:K05414]
105874210  IFNB1; interferon beta [KO:K05415]
105880942  IFNG; interferon gamma [KO:K04687]
105882477  TLR3; toll-like receptor 3 [KO:K05401]
105873915  TICAM1; LOW QUALITY PROTEIN: TIR domain-containing adapter molecule 1 [KO:K05842]
105856828  TRAF6; TNF receptor-associated factor 6 isoform X1 [KO:K03175] [EC:2.3.2.27]
105873484  RIPK1; receptor-interacting serine/threonine-protein kinase 1 [KO:K02861] [EC:2.7.11.1]
105867131  LOW QUALITY PROTEIN: inhibitor of nuclear factor kappa-B kinase subunit alpha-like [KO:K04467] [EC:2.7.11.10]
105873508  CHUK; LOW QUALITY PROTEIN: inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
105878144  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
105867816  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
105855502  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
105874819  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
105878531  RELA; transcription factor p65 isoform X1 [KO:K04735]
105858137  TNF; tumor necrosis factor isoform X1 [KO:K03156]
105859978  CXCL10; C-X-C motif chemokine 10 [KO:K12671]
105868245  EIF2AK1; eukaryotic translation initiation factor 2-alpha kinase 1 isoform X1 [KO:K16194] [EC:2.7.11.1]
105884498  EIF2AK2; interferon-induced, double-stranded RNA-activated protein kinase isoform X1 [KO:K16195] [EC:2.7.11.1]
105876638  EIF2AK3; eukaryotic translation initiation factor 2-alpha kinase 3 [KO:K08860] [EC:2.7.11.1]
105872427  EIF2AK4; eIF-2-alpha kinase GCN2 isoform X1 [KO:K16196] [EC:2.7.11.1]
105871695  interferon-induced protein with tetratricopeptide repeats 1B [KO:K14217]
105871702  LOW QUALITY PROTEIN: interferon-induced protein with tetratricopeptide repeats 1 [KO:K14217]
105883267  EIF3E; eukaryotic translation initiation factor 3 subunit E isoform X2 [KO:K03250]
105880242  EIF2S1; LOW QUALITY PROTEIN: eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
105859419  STAT3; signal transducer and activator of transcription 3 isoform X1 [KO:K04692]
105866738  SOCS3; suppressor of cytokine signaling 3 [KO:K04696]
105861517  IFNAR1; interferon alpha/beta receptor 1 [KO:K05130]
105880106  IFNAR2; interferon alpha/beta receptor 2 isoform X1 [KO:K05131]
105872820  JAK1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
105885592  TYK2; non-receptor tyrosine-protein kinase TYK2 isoform X1 [KO:K11219] [EC:2.7.10.2]
105877906  STAT1; signal transducer and activator of transcription 1-alpha/beta [KO:K11220]
105865362  STAT2; signal transducer and activator of transcription 2 [KO:K11221]
105866586  IRF9; interferon regulatory factor 9 isoform X2 [KO:K04693]
105863077  MX1; interferon-induced GTP-binding protein Mx1 [KO:K14754]
105863084  MX2; interferon-induced GTP-binding protein Mx2 [KO:K14754]
105870632  RSAD2; radical S-adenosyl methionine domain-containing protein 2 [KO:K15045]
105882885  PPP2R1A; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform [KO:K03456]
105862927  PPP2R1B; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X1 [KO:K03456]
105861838  PPP2R2C; protein phosphatase 2, regulatory subunit B, gamma isoform X1 [KO:K04354]
105876495  PPP2R2B; LOW QUALITY PROTEIN: serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform [KO:K04354]
105877116  PPP2R2A; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X1 [KO:K04354]
105880412  PPP2R2D; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform isoform X1 [KO:K04354]
105882048  PPP2CB; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
105869976  PPP2CA; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
105873437  PIAS1; E3 SUMO-protein ligase PIAS1 [KO:K04706] [EC:2.3.2.-]
105872305  EGF; LOW QUALITY PROTEIN: pro-epidermal growth factor [KO:K04357]
105877217  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
105878936  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
105867678  SOS2; son of sevenless homolog 2 [KO:K03099]
105884529  SOS1; son of sevenless homolog 1 [KO:K03099]
105874032  HRAS; GTPase HRas [KO:K02833]
105857286  KRAS; GTPase KRas isoform X1 [KO:K07827]
105878710  NRAS; GTPase NRas [KO:K07828]
105873244  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
105882676  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
105862190  ARAF; serine/threonine-protein kinase A-Raf isoform X1 [KO:K08845] [EC:2.7.11.1]
105882933  YWHAQ; 14-3-3 protein theta [KO:K16197]
105869900  YWHAZ; 14-3-3 protein zeta/delta [KO:K16197]
105879966  YWHAB; 14-3-3 protein beta/alpha [KO:K16197]
105857911  YWHAE; 14-3-3 protein epsilon isoform X1 [KO:K06630]
105868392  YWHAG; 14-3-3 protein gamma [KO:K16198]
105870971  YWHAH; 14-3-3 protein eta [KO:K16198]
105868083  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
105873938  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
105870697  mitogen-activated protein kinase 6-like [KO:K04371] [EC:2.7.11.24]
105877796  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
105871124  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
105881219  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
105855026  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
105877483  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
105862660  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
105855821  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
105886063  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
105861093  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
105876768  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
105863738  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
105879917  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
105874413  CTNNB1; catenin beta-1 [KO:K02105]
105878474  BAD; bcl2-associated agonist of cell death [KO:K02158]
105861439  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
105877486  TP53; cellular tumor antigen p53 [KO:K04451]
105864946  CDK2; cyclin-dependent kinase 2 isoform X1 [KO:K02206] [EC:2.7.11.22]
105877995  CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
105879410  CDK6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
105855966  RB1; retinoblastoma-associated protein isoform X1 [KO:K06618]
105866012  E2F1; transcription factor E2F1 [KO:K17454]
105863547  E2F2; transcription factor E2F2 isoform X1 [KO:K09389]
105865199  E2F3; transcription factor E2F3 isoform X1 [KO:K06620]
105869061  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
105859037  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
105882282  TRAF2; TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
105871667  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
105871657  FAS; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
105867530  FADD; FAS-associated death domain protein [KO:K02373]
105856959  CASP8; caspase-8 [KO:K04398] [EC:3.4.22.61]
105882502  CASP3; caspase-3 isoform X2 [KO:K02187] [EC:3.4.22.56]
105880624  LOW QUALITY PROTEIN: caspase-3-like [KO:K02187] [EC:3.4.22.56]
105856964  CFLAR; CASP8 and FADD-like apoptosis regulator isoform X1 [KO:K04724]
105861876  BID; BH3-interacting domain death agonist isoform X1 [KO:K04726]
105865602  BAX; apoptosis regulator BAX isoform X2 [KO:K02159]
105861442  BAK1; bcl-2 homologous antagonist/killer isoform X1 [KO:K14021]
105883029  cytochrome c, testis-specific [KO:K08738]
105875906  cytochrome c, somatic [KO:K08738]
105876468  cytochrome c, somatic [KO:K08738]
105883940  APAF1; apoptotic protease-activating factor 1 [KO:K02084]
105870442  CASP9; caspase-9 [KO:K04399] [EC:3.4.22.62]
105859451  PSME3; proteasome activator complex subunit 3 isoform X1 [KO:K06698]
105880812  RXRA; retinoic acid receptor RXR-alpha isoform X1 [KO:K08524]
105867270  PPARA; peroxisome proliferator-activated receptor alpha isoform X1 [KO:K07294]
105884841  NR1H3; oxysterols receptor LXR-alpha isoform X1 [KO:K08536]
105867511  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
105882748  MYC; myc proto-oncogene protein isoform X1 [KO:K04377]
Compound
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C20935  2-5A
Reference
PMID:24520529
  Authors
Hassan M, Selimovic D, El-Khattouti A, Ghozlan H, Haikel Y, Abdelkader O
  Title
Hepatitis C virus-host interactions: Etiopathogenesis and therapeutic strategies.
  Journal
World J Exp Med 2:7-25 (2012)
DOI:10.5493/wjem.v2.i2.7
Reference
PMID:23641066
  Authors
Yamauchi Y, Helenius A
  Title
Virus entry at a glance.
  Journal
J Cell Sci 126:1289-95 (2013)
DOI:10.1242/jcs.119685
Reference
PMID:24509809
  Authors
Feneant L, Levy S, Cocquerel L
  Title
CD81 and hepatitis C virus (HCV) infection.
  Journal
Viruses 6:535-72 (2014)
DOI:10.3390/v6020535
Reference
PMID:18081727
  Authors
Dubuisson J, Helle F, Cocquerel L
  Title
Early steps of the hepatitis C virus life cycle.
  Journal
Cell Microbiol 10:821-7 (2008)
DOI:10.1111/j.1462-5822.2007.01107.x
Reference
PMID:23675659
  Authors
Liang TJ, Ghany MG
  Title
Current and future therapies for hepatitis C virus infection.
  Journal
N Engl J Med 368:1907-17 (2013)
DOI:10.1056/NEJMra1213651
Reference
PMID:23836234
  Authors
Scheel TK, Rice CM
  Title
Understanding the hepatitis C virus life cycle paves the way for highly effective therapies.
  Journal
Nat Med 19:837-49 (2013)
DOI:10.1038/nm.3248
Reference
PMID:26586968
  Authors
Holmes JA, Thompson AJ
  Title
Interferon-free combination therapies for the treatment of hepatitis C: current insights.
  Journal
Hepat Med 7:51-70 (2015)
DOI:10.2147/HMER.S55864
Reference
PMID:15039538
  Authors
Taguchi T, Nagano-Fujii M, Akutsu M, Kadoya H, Ohgimoto S, Ishido S, Hotta H
  Title
Hepatitis C virus NS5A protein interacts with 2',5'-oligoadenylate synthetase and inhibits antiviral activity of IFN in an IFN sensitivity-determining region-independent manner.
  Journal
J Gen Virol 85:959-69 (2004)
DOI:10.1099/vir.0.19513-0
Reference
PMID:19708811
  Authors
Horner SM, Gale M Jr
  Title
Intracellular innate immune cascades and interferon defenses that control hepatitis C virus.
  Journal
J Interferon Cytokine Res 29:489-98 (2009)
DOI:10.1089/jir.2009.0063
Reference
PMID:20457596
  Authors
Lemon SM
  Title
Induction and evasion of innate antiviral responses by hepatitis C virus.
  Journal
J Biol Chem 285:22741-7 (2010)
DOI:10.1074/jbc.R109.099556
Reference
PMID:23836238
  Authors
Horner SM, Gale M Jr
  Title
Regulation of hepatic innate immunity by hepatitis C virus.
  Journal
Nat Med 19:879-88 (2013)
DOI:10.1038/nm.3253
Reference
PMID:28862649
  Authors
Ortega-Prieto AM, Dorner M
  Title
Immune Evasion Strategies during Chronic Hepatitis B and C Virus Infection.
  Journal
Vaccines (Basel) 5:E24 (2017)
DOI:10.3390/vaccines5030024
Reference
PMID:25852264
  Authors
Yang DR, Zhu HZ
  Title
Hepatitis C virus and antiviral innate immunity: who wins at tug-of-war?
  Journal
World J Gastroenterol 21:3786-800 (2015)
DOI:10.3748/wjg.v21.i13.3786
Reference
PMID:16107833
  Authors
Gale M Jr, Foy EM
  Title
Evasion of intracellular host defence by hepatitis C virus.
  Journal
Nature 436:939-45 (2005)
DOI:10.1038/nature04078
Reference
PMID:17467654
  Authors
Bode JG, Brenndorfer ED, Haussinger D
  Title
Subversion of innate host antiviral strategies by the hepatitis C virus.
  Journal
Arch Biochem Biophys 462:254-65 (2007)
DOI:10.1016/j.abb.2007.03.033
Reference
PMID:12686421
  Authors
Panteva M, Korkaya H, Jameel S
  Title
Hepatitis viruses and the MAPK pathway: is this a survival strategy?
  Journal
Virus Res 92:131-40 (2003)
DOI:10.1016/S0168-1702(02)00356-8
Reference
PMID:16239065
  Authors
Pang R, Tse E, Poon RT
  Title
Molecular pathways in hepatocellular carcinoma.
  Journal
Cancer Lett 240:157-69 (2006)
DOI:10.1016/j.canlet.2005.08.031
Reference
PMID:15302943
  Authors
Macdonald A, Harris M
  Title
Hepatitis C virus NS5A: tales of a promiscuous protein.
  Journal
J Gen Virol 85:2485-502 (2004)
DOI:10.1099/vir.0.80204-0
Reference
PMID:21250384
  Authors
He Y, Staschke KA, Tan SL
  Title
HCV NS5A: A Multifunctional Regulator of Cellular Pathways and Virus Replication
  Journal
Hepatitis C Viruses: Genomes and Molecular Biology (2006)
Reference
PMID:12101418
  Authors
Lan KH, Sheu ML, Hwang SJ, Yen SH, Chen SY, Wu JC, Wang YJ, Kato N, Omata M, Chang FY, Lee SD
  Title
HCV NS5A interacts with p53 and inhibits p53-mediated apoptosis.
  Journal
Oncogene 21:4801-11 (2002)
DOI:10.1038/sj.onc.1205589
Reference
PMID:11886269
  Authors
Majumder M, Ghosh AK, Steele R, Zhou XY, Phillips NJ, Ray R, Ray RB
  Title
Hepatitis C virus NS5A protein impairs TNF-mediated hepatic apoptosis, but not by an anti-FAS antibody, in transgenic mice.
  Journal
Virology 294:94-105 (2002)
DOI:10.1006/viro.2001.1309
Reference
PMID:15381253
  Authors
Hassan M, Ghozlan H, Abdel-Kader O
  Title
Activation of RB/E2F signaling pathway is required for the modulation of hepatitis C virus core protein-induced cell growth in liver and non-liver cells.
  Journal
Cell Signal 16:1375-85 (2004)
DOI:10.1016/j.cellsig.2004.04.005
Reference
PMID:11514734
  Authors
Kwun HJ, Jung EY, Ahn JY, Lee MN, Jang KL
  Title
p53-dependent transcriptional repression of p21(waf1) by hepatitis C virus NS3.
  Journal
J Gen Virol 82:2235-41 (2001)
DOI:10.1099/0022-1317-82-9-2235
Reference
PMID:12056797
  Authors
Yamanaka T, Uchida M, Doi T
  Title
Innate form of HCV core protein plays an important role in the localization and the function of HCV core protein.
  Journal
Biochem Biophys Res Commun 294:521-7 (2002)
DOI:10.1016/S0006-291X(02)00507-7
Reference
PMID:22611309
  Authors
Lim EJ, Chin R, Angus PW, Torresi J
  Title
Enhanced apoptosis in post-liver transplant hepatitis C: effects of virus and immunosuppressants.
  Journal
World J Gastroenterol 18:2172-9 (2012)
DOI:10.3748/wjg.v18.i18.2172
Reference
PMID:17828818
  Authors
Fischer R, Baumert T, Blum HE
  Title
Hepatitis C virus infection and apoptosis.
  Journal
World J Gastroenterol 13:4865-72 (2007)
DOI:10.3748/wjg.v13.i36.4865
Reference
PMID:16611896
  Authors
Saito K, Meyer K, Warner R, Basu A, Ray RB, Ray R
  Title
Hepatitis C virus core protein inhibits tumor necrosis factor alpha-mediated apoptosis by a protective effect involving cellular FLICE inhibitory protein.
  Journal
J Virol 80:4372-9 (2006)
DOI:10.1128/JVI.80.9.4372-4379.2006
Reference
PMID:19148799
  Authors
Koike K
  Title
Steatosis, liver injury, and hepatocarcinogenesis in hepatitis C viral infection.
  Journal
J Gastroenterol 44 Suppl 19:82-8 (2009)
DOI:10.1007/s00535-008-2276-4
Reference
PMID:17764115
  Authors
Tanaka N, Moriya K, Kiyosawa K, Koike K, Aoyama T
  Title
Hepatitis C virus core protein induces spontaneous and persistent activation of peroxisome proliferator-activated receptor alpha in transgenic mice: implications for HCV-associated hepatocarcinogenesis.
  Journal
Int J Cancer 122:124-31 (2008)
DOI:10.1002/ijc.23056
Reference
PMID:18251977
  Authors
Tan A, Yeh SH, Liu CJ, Cheung C, Chen PJ
  Title
Viral hepatocarcinogenesis: from infection to cancer.
  Journal
Liver Int 28:175-88 (2008)
DOI:10.1111/j.1478-3231.2007.01652.x
Related
pathway
mmur03320  PPAR signaling pathway
mmur04010  MAPK signaling pathway
mmur04144  Endocytosis
mmur04210  Apoptosis
mmur04514  Cell adhesion molecules
mmur04620  Toll-like receptor signaling pathway
mmur04622  RIG-I-like receptor signaling pathway
mmur04630  JAK-STAT signaling pathway
mmur04668  TNF signaling pathway
KO pathway
ko05160   
LinkDB

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