KEGG   PATHWAY: mmur05165
Entry
mmur05165                   Pathway                                
Name
Human papillomavirus infection - Microcebus murinus (gray mouse lemur)
Description
Human papillomavirus (HPV) is a non-enveloped, double-stranded DNA virus. HPV infect mucoal and cutaneous epithelium resulting in several types of pathologies, most notably, cervical cancer. All types of HPV share a common genomic structure and encode eight proteins: E1, E2, E4, E5, E6, and E7 (early) and L1 and L2 (late). It has been demonstrated that E1 and E2 are involved in viral transcription and replication. The functions of the E4 protein is not yet fully understood. E5, E6, and E7 act as oncoproteins. E5 inhibits the V-ATPase, prolonging EGFR signaling and thereby promoting cell proliferation. The expression of E6 and E7 not only inhibits the tumor suppressors p53 and Rb, but also alters additional signalling pathways. Among these pathways, PI3K/Akt signalling cascade plays a very important role in HPV-induced carcinogenesis. The L1 and L2 proteins form icosahedral capsids for progeny virion generation.
Class
Human Diseases; Infectious disease: viral
Pathway map
mmur05165  Human papillomavirus infection
mmur05165

Organism
Microcebus murinus (gray mouse lemur) [GN:mmur]
Gene
105869202  WNT1; proto-oncogene Wnt-1 [KO:K03209]
105869373  WNT2; protein Wnt-2 isoform X1 [KO:K00182]
105878754  WNT2B; protein Wnt-2b isoform X1 [KO:K00182]
105863673  WNT3; proto-oncogene Wnt-3 [KO:K00312]
105873607  WNT4; protein Wnt-4 isoform X1 [KO:K00408]
105861590  WNT5B; protein Wnt-5b isoform X1 [KO:K00444]
105864858  WNT5A; protein Wnt-5a isoform X1 [KO:K00444]
105857713  WNT6; protein Wnt-6 isoform X1 [KO:K00445]
105867344  WNT7B; protein Wnt-7b isoform X1 [KO:K00572]
105864522  WNT7A; protein Wnt-7a isoform X1 [KO:K00572]
105862521  WNT8A; protein Wnt-8a isoform X3 [KO:K00714]
105873639  WNT8B; protein Wnt-8b isoform X1 [KO:K00714]
105883515  WNT9B; protein Wnt-9b [KO:K01064]
105878831  WNT9A; protein Wnt-9a isoform X1 [KO:K01064]
105881062  protein Wnt-9b [KO:K01064]
105868496  WNT10B; protein Wnt-10b [KO:K01357]
105857652  WNT10A; protein Wnt-10a [KO:K01357]
105860401  WNT11; protein Wnt-11 [KO:K01384]
105867353  WNT16; protein Wnt-16 [KO:K01558]
105856944  FZD7; frizzled-7 [KO:K02432]
105879391  FZD1; frizzled-1 [KO:K02432]
105883521  FZD2; frizzled-2 [KO:K02235]
105877164  FZD3; LOW QUALITY PROTEIN: frizzled-3 [KO:K02329]
105860427  FZD4; frizzled-4 [KO:K02354]
105864316  FZD5; frizzled-5 [KO:K02375]
105871982  FZD8; LOW QUALITY PROTEIN: frizzled-8 [KO:K02375]
105882153  FZD6; frizzled-6 isoform X1 [KO:K02376]
105872762  FZD10; frizzled-10 [KO:K02842]
105858813  FZD9; frizzled-9 [KO:K02842]
105877644  DVL1; segment polarity protein dishevelled homolog DVL-1 isoform X1 [KO:K02353]
105855775  DVL3; segment polarity protein dishevelled homolog DVL-3 isoform X1 [KO:K02353]
105877972  DVL2; segment polarity protein dishevelled homolog DVL-2 isoform X1 [KO:K02353]
105879917  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
105856263  AXIN1; axin-1 isoform X1 [KO:K02157]
105861654  AXIN2; axin-2 isoform X1 [KO:K04385]
105860762  APC2; adenomatous polyposis coli protein 2 isoform X1 [KO:K02085]
105870856  APC; adenomatous polyposis coli protein isoform X1 [KO:K02085]
105874413  CTNNB1; catenin beta-1 [KO:K02105]
105862086  CSNK1A1L; casein kinase I [KO:K08957] [EC:2.7.11.1]
105858435  CSNK1A1; casein kinase I isoform X1 [KO:K08957] [EC:2.7.11.1]
105876452  TERT; telomerase reverse transcriptase isoform X1 [KO:K11126] [EC:2.7.7.49]
105869975  TCF7; LOW QUALITY PROTEIN: transcription factor 7 [KO:K02620]
105876584  TCF7L1; transcription factor 7-like 1 isoform X1 [KO:K04490]
105875160  TCF7L2; transcription factor 7-like 2 isoform X1 [KO:K04491]
105868794  UBE3A; ubiquitin-protein ligase E3A isoform X1 [KO:K10587] [EC:2.3.2.26]
105882477  TLR3; toll-like receptor 3 [KO:K05401]
105873915  TICAM1; LOW QUALITY PROTEIN: TIR domain-containing adapter molecule 1 [KO:K05842]
105859313  TNF receptor-associated factor 3-like [KO:K03174]
105861087  TRAF3; TNF receptor-associated factor 3 isoform X1 [KO:K03174]
105868963  IKBKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X1 [KO:K07211] [EC:2.7.11.10]
105880966  TBK1; serine/threonine-protein kinase TBK1 isoform X1 [KO:K05410] [EC:2.7.11.10]
105865644  IRF3; interferon regulatory factor 3 isoform X1 [KO:K05411]
105874210  IFNB1; interferon beta [KO:K05415]
105859673  CREBBP; CREB-binding protein isoform X1 [KO:K04498] [EC:2.3.1.48]
105858560  EP300; histone acetyltransferase p300 [KO:K04498] [EC:2.3.1.48]
105869037  TADA3; transcriptional adapter 3 isoform X1 [KO:K11315]
105877486  TP53; cellular tumor antigen p53 [KO:K04451]
105879085  MAGI1; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X1 [KO:K05631]
105870314  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
105857697  tensin-1-like isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
105871976  PARD3; partitioning defective 3 homolog isoform X1 [KO:K04237]
105884737  PARD6G; partitioning defective 6 homolog gamma [KO:K06093]
105872272  PARD6B; partitioning defective 6 homolog beta isoform X1 [KO:K06093]
105859026  PARD6A; partitioning defective 6 homolog alpha isoform X1 [KO:K06093]
105879189  PRKCI; protein kinase C iota type [KO:K06069] [EC:2.7.11.13]
105877684  PRKCZ; protein kinase C zeta type isoform X1 [KO:K18952] [EC:2.7.11.13]
105873610  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
105868866  SCRIB; protein scribble homolog isoform X2 [KO:K16175]
105879800  DLG1; disks large homolog 1 isoform X1 [KO:K12076]
105855256  DLG2; disks large homolog 2 isoform X1 [KO:K12075]
105856820  disks large homolog 2-like isoform X1 [KO:K12075]
105855325  DLG3; disks large homolog 3 isoform X1 [KO:K21098]
105861968  LLGL1; lethal(2) giant larvae protein homolog 1 isoform X1 [KO:K06094]
105878941  LLGL2; lethal(2) giant larvae protein homolog 2 isoform X1 [KO:K06094]
105872800  PATJ; inaD-like protein [KO:K06092]
105880235  MPP5; MAGUK p55 subfamily member 5 isoform X1 [KO:K06091]
105869041  VWF; von Willebrand factor [KO:K03900]
105872421  THBS1; thrombospondin-1 [KO:K16857]
105854973  COMP; LOW QUALITY PROTEIN: cartilage oligomeric matrix protein [KO:K04659]
105872629  THBS4; thrombospondin-4 isoform X2 [KO:K04659]
105873172  THBS3; thrombospondin-3 [KO:K04659]
105881065  THBS2; LOW QUALITY PROTEIN: thrombospondin-2 [KO:K04659]
105882608  FN1; fibronectin isoform X1 [KO:K05717]
105867267  COL1A2; collagen alpha-2(I) chain [KO:K06236]
105885109  COL1A1; collagen alpha-1(I) chain [KO:K06236]
105865821  COL2A1; collagen alpha-1(II) chain [KO:K19719]
105862838  COL4A3; collagen alpha-3(IV) chain isoform X1 [KO:K06237]
105862840  collagen alpha-4(IV) chain [KO:K06237]
105863390  COL4A5; collagen alpha-5(IV) chain isoform X1 [KO:K06237]
105863408  COL4A6; collagen alpha-6(IV) chain isoform X1 [KO:K06237]
105864191  COL4A2; collagen alpha-2(IV) chain [KO:K06237]
105864192  COL4A1; collagen alpha-1(IV) chain isoform X1 [KO:K06237]
109730989  COL6A3; LOW QUALITY PROTEIN: collagen alpha-3(VI) chain [KO:K06238]
105872697  collagen alpha-6(VI) chain [KO:K06238]
105872698  COL6A5; collagen alpha-5(VI) chain [KO:K06238]
105872699  collagen alpha-4(VI) chain-like [KO:K06238]
105879645  COL6A1; LOW QUALITY PROTEIN: collagen alpha-1(VI) chain [KO:K06238]
105879648  COL6A2; collagen alpha-2(VI) chain [KO:K06238]
105883681  COL9A1; LOW QUALITY PROTEIN: collagen alpha-1(IX) chain [KO:K08131]
105875782  COL9A3; collagen alpha-3(IX) chain [KO:K08131]
105855071  COL9A2; collagen alpha-2(IX) chain isoform X1 [KO:K08131]
105860998  LAMA1; laminin subunit alpha-1 [KO:K05637]
105855533  LAMA2; laminin subunit alpha-2 isoform X1 [KO:K05637]
105860973  LAMA3; laminin subunit alpha-3 isoform X6 [KO:K06240]
105875715  LAMA5; laminin subunit alpha-5 isoform X1 [KO:K06240]
105864934  LAMA4; laminin subunit alpha-4 isoform X1 [KO:K06241]
105860914  LAMB1; laminin subunit beta-1 isoform X1 [KO:K05636]
105874951  LAMB2; laminin subunit beta-2 [KO:K06243]
105880564  LAMB3; laminin subunit beta-3 [KO:K06244]
105860899  LAMB4; laminin subunit beta-4 isoform X1 [KO:K06245]
105855091  LAMC1; laminin subunit gamma-1 [KO:K05635]
105855571  LAMC2; laminin subunit gamma-2 [KO:K06246]
105862797  laminin subunit gamma-3-like [KO:K06247]
105865706  laminin subunit gamma-3-like [KO:K06247]
105885118  CHAD; chondroadherin [KO:K06248]
105861508  RELN; reelin isoform X1 [KO:K06249] [EC:3.4.21.-]
105876363  SPP1; osteopontin isoform X1 [KO:K06250]
105857932  VTN; vitronectin [KO:K06251]
105871632  TNR; tenascin-R isoform X1 [KO:K06252]
105871637  TNN; tenascin-N [KO:K06252]
105858141  TNXB; tenascin-X isoform X1 [KO:K06252]
105873676  TNC; tenascin isoform X1 [KO:K06252]
105876390  IBSP; bone sialoprotein 2 [KO:K06253]
105857784  ITGA1; integrin alpha-1 [KO:K06480]
105857786  ITGA2; integrin alpha-2 isoform X1 [KO:K06481]
105883554  ITGA2B; integrin alpha-IIb isoform X1 [KO:K06476]
105885102  ITGA3; integrin alpha-3 isoform X1 [KO:K06482]
105883005  ITGA4; integrin alpha-4 isoform X1 [KO:K06483]
105871251  ITGA5; integrin alpha-5 [KO:K06484]
105880728  ITGA6; integrin alpha-6 isoform X1 [KO:K06485]
105864777  ITGA7; integrin alpha-7 isoform X1 [KO:K06583]
105856364  ITGA8; integrin alpha-8 [KO:K06584]
105860551  ITGA9; integrin alpha-9 [KO:K06585]
105869828  ITGA10; integrin alpha-10 isoform X2 [KO:K06586]
105873431  ITGA11; integrin alpha-11 isoform X1 [KO:K06587]
105879310  ITGAV; integrin alpha-V isoform X1 [KO:K06487]
105857729  ITGB1; integrin beta-1 [KO:K05719]
105863671  ITGB3; integrin beta-3 [KO:K06493]
105878947  ITGB4; integrin beta-4 isoform X2 [KO:K06525]
105879856  ITGB5; integrin beta-5 isoform X1 [KO:K06588]
105860472  ITGB6; integrin beta-6 isoform X1 [KO:K06589]
105870631  ITGB7; integrin beta-7 isoform X1 [KO:K06590]
105880184  ITGB8; integrin beta-8 isoform X1 [KO:K06591]
105855154  PTK2; focal adhesion kinase 1 [KO:K05725] [EC:2.7.10.2]
105866870  PXN; paxillin isoform X7 [KO:K05760]
105858137  TNF; tumor necrosis factor isoform X1 [KO:K03156]
105869061  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
105859037  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
105871667  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
105871657  FAS; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
105867530  FADD; FAS-associated death domain protein [KO:K02373]
105856959  CASP8; caspase-8 [KO:K04398] [EC:3.4.22.61]
105882502  CASP3; caspase-3 isoform X2 [KO:K02187] [EC:3.4.22.56]
105880624  LOW QUALITY PROTEIN: caspase-3-like [KO:K02187] [EC:3.4.22.56]
105878907  SLC9A3R1; Na(+)/H(+) exchange regulatory cofactor NHE-RF1 [KO:K13365]
105882048  PPP2CB; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
105869976  PPP2CA; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
105882885  PPP2R1A; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform [KO:K03456]
105862927  PPP2R1B; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X1 [KO:K03456]
105861838  PPP2R2C; protein phosphatase 2, regulatory subunit B, gamma isoform X1 [KO:K04354]
105876495  PPP2R2B; LOW QUALITY PROTEIN: serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform [KO:K04354]
105877116  PPP2R2A; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X1 [KO:K04354]
105880412  PPP2R2D; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform isoform X1 [KO:K04354]
105884065  PPP2R3A; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha isoform X1 [KO:K11583]
105855491  PPP2R3C; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma isoform X1 [KO:K11583]
105865093  PPP2R3B; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta [KO:K11583]
105861072  PPP2R5C; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X1 [KO:K11584]
105875833  PPP2R5D; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform [KO:K11584]
105878328  PPP2R5E; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform isoform X1 [KO:K11584]
105878495  PPP2R5B; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform [KO:K11584]
105880541  PPP2R5A; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform [KO:K11584]
105859868  TSC1; hamartin isoform X1 [KO:K07206]
105859584  TSC2; tuberin isoform X1 [KO:K07207]
105883192  RHEB; GTP-binding protein Rheb isoform X1 [KO:K07208]
105886039  MTOR; serine/threonine-protein kinase mTOR isoform X1 [KO:K07203] [EC:2.7.11.1]
105870389  EIF4EBP1; eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
105867475  RPS6KB2; ribosomal protein S6 kinase beta-2 [KO:K04688] [EC:2.7.11.1]
105874527  RPS6KB1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
105861442  BAK1; bcl-2 homologous antagonist/killer isoform X1 [KO:K14021]
105878474  BAD; bcl2-associated agonist of cell death [KO:K02158]
105858450  PDGFRB; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
105862660  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
105855821  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
105886063  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
105881219  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
105855026  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
105877483  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
105861093  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
105876768  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
105863738  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
105868033  FOXO1; forkhead box protein O1 [KO:K07201]
105876702  CDKN1B; cyclin-dependent kinase inhibitor 1B [KO:K06624]
105861439  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
105867511  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
105881459  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
105875858  CCND3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
105877995  CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
105879410  CDK6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
105875662  CCNE2; G1/S-specific cyclin-E2 isoform X1 [KO:K06626]
105877006  CCNE1; G1/S-specific cyclin-E1 [KO:K06626]
105864946  CDK2; cyclin-dependent kinase 2 isoform X1 [KO:K02206] [EC:2.7.11.22]
105855966  RB1; retinoblastoma-associated protein isoform X1 [KO:K06618]
105865895  RBL1; retinoblastoma-like protein 1 isoform X1 [KO:K04681]
105875529  RBL2; retinoblastoma-like protein 2 isoform X1 [KO:K16332]
105876295  PSMC1; 26S protease regulatory subunit 4 [KO:K03062]
105866012  E2F1; transcription factor E2F1 [KO:K17454]
105882110  CCNA2; cyclin-A2 [KO:K06627]
105862090  CCNA1; cyclin-A1 [KO:K06627]
105876116  ATM; LOW QUALITY PROTEIN: serine-protein kinase ATM [KO:K04728] [EC:2.7.11.1]
105870060  ATR; serine/threonine-protein kinase ATR isoform X1 [KO:K06640] [EC:2.7.11.1]
105875869  VEGFA; vascular endothelial growth factor A [KO:K05448]
105867131  LOW QUALITY PROTEIN: inhibitor of nuclear factor kappa-B kinase subunit alpha-like [KO:K04467] [EC:2.7.11.10]
105873508  CHUK; LOW QUALITY PROTEIN: inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
105878144  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
105867816  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
105874819  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
105878531  RELA; transcription factor p65 isoform X1 [KO:K04735]
105884627  LOW QUALITY PROTEIN: E3 ubiquitin-protein ligase Mdm2 [KO:K06643] [EC:2.3.2.27]
105874367  NFX1; transcriptional repressor NF-X1 isoform X2 [KO:K12236]
105871810  HDAC1; histone deacetylase 1 isoform X1 [KO:K06067] [EC:3.5.1.98]
105864982  HDAC2; LOW QUALITY PROTEIN: histone deacetylase 2 [KO:K06067] [EC:3.5.1.98]
105869006  CHD4; chromodomain-helicase-DNA-binding protein 4 isoform X1 [KO:K11643] [EC:5.6.2.-]
105869950  IRF1; interferon regulatory factor 1 isoform X1 [KO:K09444]
105867722  TBPL2; TATA box-binding protein-like protein 2 [KO:K03120]
105880531  TBPL1; TATA box-binding protein-like protein 1 [KO:K03120]
105881080  TBP; TATA-box-binding protein [KO:K03120]
105855949  HLA class I histocompatibility antigen, B-81 alpha chain-like [KO:K06751]
105855951  LOW QUALITY PROTEIN: HLA class I histocompatibility antigen, B-37 alpha chain-like [KO:K06751]
105870762  LOW QUALITY PROTEIN: saoe class I histocompatibility antigen, A alpha chain-like [KO:K06751]
105870764  HLA class I histocompatibility antigen, B-37 alpha chain-like isoform X1 [KO:K06751]
105870765  HLA class I histocompatibility antigen, B-48 alpha chain-like [KO:K06751]
105870766  HLA class I histocompatibility antigen, B-44 alpha chain-like [KO:K06751]
105870767  LOW QUALITY PROTEIN: HLA class I histocompatibility antigen, alpha chain G-like [KO:K06751]
105858107  LOW QUALITY PROTEIN: class I histocompatibility antigen, Gogo-OKO alpha chain [KO:K06751]
105867310  BCAP31; B-cell receptor-associated protein 31 [KO:K14009]
105883925  ATP6V1A; V-type proton ATPase catalytic subunit A [KO:K02145] [EC:7.1.2.2]
105882561  ATP6V1B2; LOW QUALITY PROTEIN: V-type proton ATPase subunit B, brain isoform [KO:K02147]
105863253  ATP6V1B1; V-type proton ATPase subunit B, kidney isoform isoform X1 [KO:K02147]
105882158  ATP6V1C1; V-type proton ATPase subunit C 1 [KO:K02148]
105879031  ATP6V1C2; V-type proton ATPase subunit C 2 isoform X2 [KO:K02148]
105880241  ATP6V1D; LOW QUALITY PROTEIN: V-type proton ATPase subunit D [KO:K02149]
105867065  ATP6V1E2; V-type proton ATPase subunit E 2 [KO:K02150]
105861868  ATP6V1E1; V-type proton ATPase subunit E 1 [KO:K02150]
105884851  ATP6V1F; V-type proton ATPase subunit F [KO:K02151]
105860071  ATP6V1G3; V-type proton ATPase subunit G 3 [KO:K02152]
105858140  ATP6V1G2; V-type proton ATPase subunit G 2 isoform X1 [KO:K02152]
105873684  ATP6V1G1; V-type proton ATPase subunit G 1 [KO:K02152]
105864102  ATP6V1H; V-type proton ATPase subunit H [KO:K02144]
105859413  ATP6V0A1; V-type proton ATPase 116 kDa subunit a isoform X1 [KO:K02154]
105867428  TCIRG1; V-type proton ATPase 116 kDa subunit a [KO:K02154]
105859114  ATP6V0A4; V-type proton ATPase 116 kDa subunit a [KO:K02154]
105880859  ATP6V0A2; V-type proton ATPase 116 kDa subunit a [KO:K02154]
105876551  ATP6V0D2; V-type proton ATPase subunit d 2 [KO:K02146]
105859010  ATP6V0D1; V-type proton ATPase subunit d 1 [KO:K02146]
105883147  ATP6V0E2; LOW QUALITY PROTEIN: V-type proton ATPase subunit e 2 [KO:K02153]
105871868  ATP6V0E1; V-type proton ATPase subunit e 1 [KO:K02153]
105859675  ATP6V0C; V-type proton ATPase 16 kDa proteolipid subunit [KO:K02155]
105877430  ATP6V0B; V-type proton ATPase 21 kDa proteolipid subunit isoform X1 [KO:K03661]
105867808  ATP6AP1; V-type proton ATPase subunit S1 [KO:K03662]
105872305  EGF; LOW QUALITY PROTEIN: pro-epidermal growth factor [KO:K04357]
105877217  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
105878936  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
105867678  SOS2; son of sevenless homolog 2 [KO:K03099]
105884529  SOS1; son of sevenless homolog 1 [KO:K03099]
105874032  HRAS; GTPase HRas [KO:K02833]
105857286  KRAS; GTPase KRas isoform X1 [KO:K07827]
105878710  NRAS; GTPase NRas [KO:K07828]
105882676  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
105868083  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
105873938  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
105870697  mitogen-activated protein kinase 6-like [KO:K04371] [EC:2.7.11.24]
105877796  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
105871124  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
105855505  PTGS2; prostaglandin G/H synthase 2 isoform X1 [KO:K11987] [EC:1.14.99.1]
105878396  PTGER4; prostaglandin E2 receptor EP4 subtype [KO:K04261]
105874518  guanine nucleotide-binding protein G(s) subunit alpha isoforms short isoform X1 [KO:K04632]
105874520  neuroendocrine secretory protein 55-like [KO:K04632]
105867963  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
105861780  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X2 [KO:K04345] [EC:2.7.11.11]
105865602  BAX; apoptosis regulator BAX isoform X2 [KO:K02159]
105864304  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
105873936  CREB3L3; cyclic AMP-responsive element-binding protein 3-like protein 3 isoform X1 [KO:K09048]
105874305  CREB3; cyclic AMP-responsive element-binding protein 3 [KO:K09048]
105885209  CREB3L1; cyclic AMP-responsive element-binding protein 3-like protein 1 isoform X1 [KO:K09048]
105885942  CREB3L4; cyclic AMP-responsive element-binding protein 3-like protein 4 [KO:K09048]
105859108  CREB3L2; cyclic AMP-responsive element-binding protein 3-like protein 2 [KO:K09048]
105855129  cyclic AMP-responsive element-binding protein 5 isoform X1 [KO:K09047]
105883979  E3 ubiquitin-protein ligase UBR4 [KO:K10691] [EC:2.3.2.27]
105865472  E3 ubiquitin-protein ligase UBR4-like [KO:K10691] [EC:2.3.2.27]
105859402  tubulin gamma-2 chain [KO:K10389]
105859406  TUBG1; tubulin gamma-1 chain [KO:K10389]
105877255  LOW QUALITY PROTEIN: tubulin gamma-2 chain-like [KO:K10389]
105873389  PKM; pyruvate kinase PKM isoform X1 [KO:K00873] [EC:2.7.1.40]
105874211  interferon alpha-10-like [KO:K05414]
105874212  interferon alpha-10-like [KO:K05414]
105874214  interferon alpha-4-like [KO:K05414]
105874217  interferon alpha-10-like [KO:K05414]
105861517  IFNAR1; interferon alpha/beta receptor 1 [KO:K05130]
105880106  IFNAR2; interferon alpha/beta receptor 2 isoform X1 [KO:K05131]
105872820  JAK1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
105885592  TYK2; non-receptor tyrosine-protein kinase TYK2 isoform X1 [KO:K11219] [EC:2.7.10.2]
105877906  STAT1; signal transducer and activator of transcription 1-alpha/beta [KO:K11220]
105865362  STAT2; signal transducer and activator of transcription 2 [KO:K11221]
105866586  IRF9; interferon regulatory factor 9 isoform X2 [KO:K04693]
105884498  EIF2AK2; interferon-induced, double-stranded RNA-activated protein kinase isoform X1 [KO:K16195] [EC:2.7.11.1]
105866844  LOW QUALITY PROTEIN: 2'-5'-oligoadenylate synthase-like protein 2 [KO:K14608]
105866959  OASL; 2'-5'-oligoadenylate synthase-like protein [KO:K14608]
105863077  MX1; interferon-induced GTP-binding protein Mx1 [KO:K14754]
105863084  MX2; interferon-induced GTP-binding protein Mx2 [KO:K14754]
105877689  ISG15; ubiquitin-like protein ISG15 [KO:K12159]
105880047  JAG1; protein jagged-1 [KO:K06052]
105880779  NOTCH1; neurogenic locus notch homolog protein 1 [KO:K02599]
105869800  NOTCH2; neurogenic locus notch homolog protein 2 [KO:K20994]
105867903  NOTCH3; LOW QUALITY PROTEIN: neurogenic locus notch homolog protein 3 [KO:K20995]
105858142  NOTCH4; neurogenic locus notch homolog protein 4 isoform X1 [KO:K20996]
105858213  PSEN1; presenilin-1 [KO:K04505] [EC:3.4.23.-]
105868435  LFNG; beta-1,3-N-acetylglucosaminyltransferase lunatic fringe isoform X1 [KO:K05948] [EC:2.4.1.222]
105883754  MFNG; beta-1,3-N-acetylglucosaminyltransferase manic fringe isoform X1 [KO:K05948] [EC:2.4.1.222]
105878072  RFNG; LOW QUALITY PROTEIN: beta-1,3-N-acetylglucosaminyltransferase radical fringe [KO:K05948] [EC:2.4.1.222]
105859773  MAML2; mastermind-like protein 2 isoform X1 [KO:K06061]
105885201  MAML1; mastermind-like protein 1 [KO:K06061]
105872350  MAML3; mastermind-like protein 3 isoform X1 [KO:K06061]
105879842  RBPJL; recombining binding protein suppressor of hairless-like protein [KO:K06053]
105865767  RBPJ; recombining binding protein suppressor of hairless isoform X1 [KO:K06053]
105879778  HES1; transcription factor HES-1 [KO:K06054]
105877271  HES7; transcription factor HES-7 isoform X2 [KO:K09087]
105886036  HES2; transcription factor HES-2 [KO:K09087]
105866417  HES6; transcription cofactor HES-6 isoform X1 [KO:K09087]
105886118  HES3; transcription factor HES-3 [KO:K09088]
105877631  HES4; transcription factor HES-4 [KO:K09089]
105877383  HES5; transcription factor HES-5 [KO:K06055]
105878200  HEY2; hairy/enhancer-of-split related with YRPW motif protein 2 [KO:K09091]
105857587  HEY1; LOW QUALITY PROTEIN: hairy/enhancer-of-split related with YRPW motif protein 1 [KO:K09091]
105879536  HEYL; hairy/enhancer-of-split related with YRPW motif-like protein isoform X1 [KO:K09091]
Compound
C00575  3',5'-Cyclic AMP
C00584  Prostaglandin E2
C05981  Phosphatidylinositol-3,4,5-trisphosphate
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Human papillomavirus oncoproteins: pathways to transformation.
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Nat Rev Cancer 10:550-60 (2010)
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Signaling pathways in HPV-associated cancers and therapeutic implications.
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Rev Med Virol 25 Suppl 1:24-53 (2015)
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High-risk human papillomavirus targets crossroads in immune signaling.
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Viruses 7:2485-506 (2015)
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Molecular mechanisms of human papillomavirus-induced carcinogenesis.
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Human papillomavirus proteins as prospective therapeutic targets.
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Molecular mechanisms of cervical carcinogenesis by high-risk human papillomaviruses: novel functions of E6 and E7 oncoproteins.
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Rev Med Virol 19:97-113 (2009)
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Reference
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Basic mechanisms of high-risk human papillomavirus-induced carcinogenesis: roles of E6 and E7 proteins.
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Cancer Sci 98:1505-11 (2007)
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PMID:11486705
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The molecular biology of cervical cancer.
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Reference
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Papillomaviruses causing cancer: evasion from host-cell control in early events in carcinogenesis.
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J Natl Cancer Inst 92:690-8 (2000)
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Aberrant cell cycle regulation in cervical carcinoma.
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Reference
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Human papillomaviruses and cell signaling.
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Sci STKE 2005:pe29 (2005)
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The role of human papilloma virus in the molecular biology of cervical carcinogenesis.
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The human papillomavirus family and its role in carcinogenesis.
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Semin Cancer Biol 26:13-21 (2014)
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Regulation of the Wnt/beta-Catenin Signaling Pathway by Human Papillomavirus E6 and E7 Oncoproteins.
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Viruses 7:4734-55 (2015)
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Reference
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In silico mechanistic analysis of IRF3 inactivation and high-risk HPV E6 species-dependent drug response.
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Sci Rep 5:13446 (2015)
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James CD, Roberts S
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Viral Interactions with PDZ Domain-Containing Proteins-An Oncogenic Trait?
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Pathogens 5:E8 (2016)
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The Human Papillomavirus E6 PDZ Binding Motif: From Life Cycle to Malignancy.
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Viruses 7:3530-51 (2015)
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Reference
PMID:21954943
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PDZ domains: the building blocks regulating tumorigenesis.
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Biochem J 439:195-205 (2011)
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Human tumour viruses and the deregulation of cell polarity in cancer.
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Nat Rev Cancer 12:877-86 (2012)
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Human papillomaviruses, cervical cancer and cell polarity.
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Cell intrinsic & extrinsic factors in cervical carcinogenesis.
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Mol Cell Proteomics 11:M112.016998 (2012)
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Reference
PMID:9990017
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Modulation of type M2 pyruvate kinase activity by the human papillomavirus type 16 E7 oncoprotein.
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Reference
PMID:15175323
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Lu Z, Hu X, Li Y, Zheng L, Zhou Y, Jiang H, Ning T, Basang Z, Zhang C, Ke Y
  Title
Human papillomavirus 16 E6 oncoprotein interferences with insulin signaling pathway by binding to tuberin.
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J Biol Chem 279:35664-70 (2004)
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Reference
PMID:18505829
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Xu M, Luo W, Elzi DJ, Grandori C, Galloway DA
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NFX1 interacts with mSin3A/histone deacetylase to repress hTERT transcription in keratinocytes.
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Mol Cell Biol 28:4819-28 (2008)
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Reference
PMID:23536685
  Authors
Raff AB, Woodham AW, Raff LM, Skeate JG, Yan L, Da Silva DM, Schelhaas M, Kast WM
  Title
The evolving field of human papillomavirus receptor research: a review of binding and entry.
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J Virol 87:6062-72 (2013)
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Related
pathway
mmur04064  NF-kappa B signaling pathway
mmur04110  Cell cycle
mmur04115  p53 signaling pathway
mmur04150  mTOR signaling pathway
mmur04151  PI3K-Akt signaling pathway
mmur04210  Apoptosis
mmur04310  Wnt signaling pathway
mmur04330  Notch signaling pathway
mmur04510  Focal adhesion
mmur04520  Adherens junction
mmur04530  Tight junction
mmur04612  Antigen processing and presentation
mmur04620  Toll-like receptor signaling pathway
mmur04630  JAK-STAT signaling pathway
KO pathway
ko05165   
LinkDB

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