KEGG   PATHWAY: mmur05207
Entry
mmur05207                   Pathway                                
Name
Chemical carcinogenesis - receptor activation - Microcebus murinus (gray mouse lemur)
Description
Carcinogenesis is a multistage process that consists of initiation, promotion, and progression stages. Chemicals or environmental factors may act at any of these stages to induce and/or enhance the carcinogenic process. Based on their mode-of-action, carcinogens can be classified as genotoxic or non-genotoxic. Genotoxic agent begins their action at the deoxyribonucleic acid (DNA) level, causing DNA damage through several mechanisms. Non-genotoxic carcinogens are chemicals that cause the development of tumors through multiple non-genotoxic events and epigenetic alterations without direct interaction with DNA. One non-genotoxic mechanism involves receptor activation. Biological mechanisms involving receptor activation fall into two broad categories: (i) those that involve cell surface receptors and some intracellular receptors that activate signal transduction pathways, resulting in biological responses, including gene transcription, and (ii) those that involve intracellular receptors that translocate into the nucleus and act as transcription factors regulating gene expression. Both classes of receptors can be involved in mechanisms of carcinogenesis.
Class
Human Diseases; Cancer: overview
Pathway map
mmur05207  Chemical carcinogenesis - receptor activation
mmur05207

Organism
Microcebus murinus (gray mouse lemur) [GN:mmur]
Gene
105871313  CHRNA7; neuronal acetylcholine receptor subunit alpha-7 [KO:K04809]
105860366  ARRB1; beta-arrestin-1 isoform X1 [KO:K04439]
105879284  ARRB2; beta-arrestin-2 isoform X1 [KO:K04439]
105866030  SRC; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
105882676  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
105855966  RB1; retinoblastoma-associated protein isoform X1 [KO:K06618]
105866012  E2F1; transcription factor E2F1 [KO:K17454]
105866736  BIRC5; baculoviral IAP repeat-containing protein 5 [KO:K08731]
105860713  XIAP; E3 ubiquitin-protein ligase XIAP isoform X1 [KO:K04725] [EC:2.3.2.27]
105872082  CDC6; cell division control protein 6 homolog [KO:K02213]
105874913  CDC25A; M-phase inducer phosphatase 1 isoform X1 [KO:K06645] [EC:3.1.3.48]
105856276  JAK2; tyrosine-protein kinase JAK2 isoform X1 [KO:K04447] [EC:2.7.10.2]
105859419  STAT3; signal transducer and activator of transcription 3 isoform X1 [KO:K04692]
105868963  IKBKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X1 [KO:K07211] [EC:2.7.11.10]
105867511  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
105875794  CHRNA4; neuronal acetylcholine receptor subunit alpha-4 isoform X1 [KO:K04806]
105873199  CHRNB2; neuronal acetylcholine receptor subunit beta-2 isoform X2 [KO:K04813]
105857202  CHRNA3; neuronal acetylcholine receptor subunit alpha-3 isoform X1 [KO:K04805]
105857199  CHRNB4; neuronal acetylcholine receptor subunit beta-4 isoform X2 [KO:K04815]
105857200  neuronal acetylcholine receptor subunit beta-4 [KO:K04815]
105861596  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
105875072  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
105856433  CACNA1F; voltage-dependent L-type calcium channel subunit alpha-1F isoform X1 [KO:K04853]
105859992  CACNA1S; LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
105882232  CACNA1B; voltage-dependent N-type calcium channel subunit alpha-1B isoform X1 [KO:K04849]
105885431  CACNA1A; LOW QUALITY PROTEIN: voltage-dependent P/Q-type calcium channel subunit alpha-1A [KO:K04344]
105862660  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
105855821  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
105886063  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
105881219  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
105855026  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
105877483  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
105861093  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
105876768  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
105863738  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
105886039  MTOR; serine/threonine-protein kinase mTOR isoform X1 [KO:K07203] [EC:2.7.11.1]
105874819  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
105878531  RELA; transcription factor p65 isoform X1 [KO:K04735]
105874032  HRAS; GTPase HRas [KO:K02833]
105857286  KRAS; GTPase KRas isoform X1 [KO:K07827]
105878710  NRAS; GTPase NRas [KO:K07828]
105868083  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
105873938  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
105870697  mitogen-activated protein kinase 6-like [KO:K04371] [EC:2.7.11.24]
105877796  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
105871124  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
105858849  FOS; proto-oncogene c-Fos [KO:K04379]
105882585  JUN; transcription factor AP-1 [KO:K04448]
105882748  MYC; myc proto-oncogene protein isoform X1 [KO:K04377]
105876728  BCL2; apoptosis regulator Bcl-2 [KO:K02161]
105861618  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
105879718  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
105874723  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
105875869  VEGFA; vascular endothelial growth factor A [KO:K05448]
105882072  FGF2; LOW QUALITY PROTEIN: fibroblast growth factor 2 [KO:K18497]
105875389  ADRB1; beta-1 adrenergic receptor [KO:K04141]
105858458  ADRB2; beta-2 adrenergic receptor [KO:K04142]
105870388  ADRB3; beta-3 adrenergic receptor isoform X1 [KO:K04143]
105874518  guanine nucleotide-binding protein G(s) subunit alpha isoforms short isoform X1 [KO:K04632]
105874520  neuroendocrine secretory protein 55-like [KO:K04632]
105870668  ADCY1; LOW QUALITY PROTEIN: adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
105859934  ADCY2; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
105884349  ADCY3; adenylate cyclase type 3 [KO:K08043] [EC:4.6.1.1]
105866617  ADCY4; adenylate cyclase type 4 isoform X1 [KO:K08044] [EC:4.6.1.1]
105879870  ADCY5; LOW QUALITY PROTEIN: adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
105867497  ADCY6; adenylate cyclase type 6 isoform X1 [KO:K08046] [EC:4.6.1.1]
105884745  ADCY7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
105882731  ADCY8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
105859653  ADCY9; adenylate cyclase type 9 isoform X2 [KO:K08049] [EC:4.6.1.1]
105867963  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
105861780  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X2 [KO:K04345] [EC:2.7.11.11]
105864304  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
105865052  ATF2; LOW QUALITY PROTEIN: cyclic AMP-dependent transcription factor ATF-2 [KO:K04450]
105858535  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
105873936  CREB3L3; cyclic AMP-responsive element-binding protein 3-like protein 3 isoform X1 [KO:K09048]
105874305  CREB3; cyclic AMP-responsive element-binding protein 3 [KO:K09048]
105885209  CREB3L1; cyclic AMP-responsive element-binding protein 3-like protein 1 isoform X1 [KO:K09048]
105885942  CREB3L4; cyclic AMP-responsive element-binding protein 3-like protein 4 [KO:K09048]
105859108  CREB3L2; cyclic AMP-responsive element-binding protein 3-like protein 2 [KO:K09048]
105855129  cyclic AMP-responsive element-binding protein 5 isoform X1 [KO:K09047]
105858143  ATF6B; cyclic AMP-dependent transcription factor ATF-6 beta isoform X1 [KO:K09049]
105874990  GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630]
105864008  GNAI3; guanine nucleotide-binding protein G(k) subunit alpha [KO:K04630]
105879338  GNAI1; guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
105878474  BAD; bcl2-associated agonist of cell death [KO:K02158]
105865430  CHRNA9; neuronal acetylcholine receptor subunit alpha-9 [KO:K04810]
105882367  RPS6KA3; ribosomal protein S6 kinase alpha-3 isoform X1 [KO:K04373] [EC:2.7.11.1]
105863518  RPS6KA1; ribosomal protein S6 kinase alpha-1 isoform X1 [KO:K04373] [EC:2.7.11.1]
105877858  RPS6KA2; ribosomal protein S6 kinase alpha-2 isoform X1 [KO:K04373] [EC:2.7.11.1]
105856794  RPS6KA6; ribosomal protein S6 kinase alpha-6 isoform X1 [KO:K04373] [EC:2.7.11.1]
105858071  ESR1; estrogen receptor [KO:K08550]
105878331  ESR2; estrogen receptor beta isoform X1 [KO:K08551]
105865468  VDR; vitamin D3 receptor [KO:K08539]
105875858  CCND3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
105877217  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
105878936  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
105867678  SOS2; son of sevenless homolog 2 [KO:K03099]
105884529  SOS1; son of sevenless homolog 1 [KO:K03099]
105870389  EIF4EBP1; eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
105867475  RPS6KB2; ribosomal protein S6 kinase beta-2 [KO:K04688] [EC:2.7.11.1]
105874527  RPS6KB1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
105863435  PAQR7; membrane progestin receptor alpha [KO:K25039]
105869186  PAQR8; membrane progestin receptor beta isoform X1 [KO:K25040]
105873417  PAQR5; membrane progestin receptor gamma isoform X1 [KO:K25041]
105874579  PGR; progesterone receptor isoform X1 [KO:K08556]
105869318  TNFSF11; tumor necrosis factor ligand superfamily member 11 [KO:K05473]
105859421  signal transducer and activator of transcription 5A [KO:K11223]
105859420  STAT5B; signal transducer and activator of transcription 5B isoform X1 [KO:K11224]
105885049  BCL6; B-cell lymphoma 6 protein [KO:K15618]
105876435  KLF5; Krueppel-like factor 5 isoform X1 [KO:K09206]
105855701  KLF4; Krueppel-like factor 4 isoform X1 [KO:K17846]
105869202  WNT1; proto-oncogene Wnt-1 [KO:K03209]
105869800  NOTCH2; neurogenic locus notch homolog protein 2 [KO:K20994]
105880047  JAG1; protein jagged-1 [KO:K06052]
105855349  AR; androgen receptor [KO:K08557]
105872305  EGF; LOW QUALITY PROTEIN: pro-epidermal growth factor [KO:K04357]
105881454  FGF6; fibroblast growth factor 6 [KO:K04358]
105873977  FGF8; fibroblast growth factor 8 isoform X1 [KO:K04358]
105867172  FGF18; fibroblast growth factor 18 [KO:K04358]
105867400  FGF3; fibroblast growth factor 3 [KO:K04358]
105867413  FGF4; fibroblast growth factor 4 [KO:K04358]
105882525  FGF20; fibroblast growth factor 20 [KO:K04358]
105860843  FGF22; fibroblast growth factor 22 isoform X1 [KO:K04358]
105884926  FGF5; fibroblast growth factor 5 isoform X1 [KO:K04358]
105870727  FGF7; fibroblast growth factor 7 [KO:K04358]
105857128  FGF17; fibroblast growth factor 17 isoform X1 [KO:K04358]
105878875  FGF9; fibroblast growth factor 9 [KO:K04358]
105857795  FGF10; fibroblast growth factor 10 [KO:K04358]
105866146  FGF16; fibroblast growth factor 16 [KO:K04358]
105876785  DLL3; delta-like protein 3 [KO:K06051]
105872462  DLL4; delta-like protein 4 isoform X1 [KO:K06051]
105881075  DLL1; delta-like protein 1 [KO:K06051]
105865527  PTGES3; prostaglandin E synthase 3 isoform X1 [KO:K15730] [EC:5.3.99.3]
105867505  AIP; AH receptor-interacting protein isoform X1 [KO:K17767]
105879129  AIPL1; aryl-hydrocarbon-interacting protein-like 1 [KO:K17767]
105880194  AHR; aryl hydrocarbon receptor [KO:K09093]
105859524  HSP90AB1; LOW QUALITY PROTEIN: heat shock protein HSP 90-beta [KO:K04079]
105861065  HSP90AA1; heat shock protein HSP 90-alpha [KO:K04079]
105875581  HSP90B1; endoplasmin [KO:K09487]
105879885  KPNA1; importin subunit alpha-5 [KO:K23940]
105868320  KPNA7; importin subunit alpha-8 isoform X1 [KO:K15043]
105861662  KPNA2; LOW QUALITY PROTEIN: importin subunit alpha-1 [KO:K15043]
105863032  LOW QUALITY PROTEIN: importin subunit alpha-8-like [KO:K15043]
105881194  KPNA4; importin subunit alpha-3 [KO:K23583]
105855988  KPNA3; importin subunit alpha-4 isoform X1 [KO:K23583]
105871822  KPNA6; importin subunit alpha-7 isoform X1 [KO:K15042]
105865350  KPNA5; importin subunit alpha-6 isoform X1 [KO:K15042]
105872146  KPNB1; importin subunit beta-1 [KO:K14293]
105873069  ARNT; LOW QUALITY PROTEIN: aryl hydrocarbon receptor nuclear translocator [KO:K09097]
105854864  cytochrome P450 1A1 [KO:K07408] [EC:1.14.14.1]
105884508  cytochrome P450 1B1 [KO:K07410] [EC:1.14.14.1]
105863794  EPHX1; epoxide hydrolase 1 [KO:K01253] [EC:3.3.2.9]
105877163  EPHX2; bifunctional epoxide hydrolase 2 [KO:K08726] [EC:3.3.2.10 3.1.3.76]
105867940  EPHX3; epoxide hydrolase 3 [KO:K22368] [EC:3.3.2.10]
105885719  EPHX4; epoxide hydrolase 4 [KO:K22369] [EC:3.3.-.-]
105874655  GSTO2; glutathione S-transferase omega-2 [KO:K00799] [EC:2.5.1.18]
105874660  GSTO1; glutathione S-transferase omega-1 [KO:K00799] [EC:2.5.1.18]
105860497  MGST3; microsomal glutathione S-transferase 3 [KO:K00799] [EC:2.5.1.18]
105869168  glutathione S-transferase-like isoform X1 [KO:K00799] [EC:2.5.1.18]
105869170  LOW QUALITY PROTEIN: glutathione S-transferase A4-like [KO:K00799] [EC:2.5.1.18]
105869190  glutathione S-transferase A1-like isoform X1 [KO:K00799] [EC:2.5.1.18]
105869191  glutathione S-transferase A3-like [KO:K00799] [EC:2.5.1.18]
105869211  glutathione S-transferase A4 isoform X1 [KO:K00799] [EC:2.5.1.18]
105869212  LOW QUALITY PROTEIN: glutathione S-transferase A3-like [KO:K00799] [EC:2.5.1.18]
105862780  LOW QUALITY PROTEIN: glutathione S-transferase theta-2B-like [KO:K00799] [EC:2.5.1.18]
105862781  glutathione S-transferase theta-4 [KO:K00799] [EC:2.5.1.18]
105862782  glutathione S-transferase theta-3 [KO:K00799] [EC:2.5.1.18]
105862783  glutathione S-transferase theta-1 isoform X1 [KO:K00799] [EC:2.5.1.18]
105877389  MGST1; microsomal glutathione S-transferase 1 [KO:K00799] [EC:2.5.1.18]
105863995  GSTM4; glutathione S-transferase Mu 4 isoform X1 [KO:K00799] [EC:2.5.1.18]
105863998  glutathione S-transferase Mu 2 [KO:K00799] [EC:2.5.1.18]
105864000  GSTM3; glutathione S-transferase Mu 3 [KO:K00799] [EC:2.5.1.18]
109729221  glutathione S-transferase Mu 2-like [KO:K00799] [EC:2.5.1.18]
105872351  MGST2; microsomal glutathione S-transferase 2 isoform X1 [KO:K00799] [EC:2.5.1.18]
105883051  UDP-glucuronosyltransferase 2B4-like [KO:K00699] [EC:2.4.1.17]
105883080  UDP-glucuronosyltransferase 2B17-like [KO:K00699] [EC:2.4.1.17]
105883081  UDP-glucuronosyltransferase 2B7-like isoform X1 [KO:K00699] [EC:2.4.1.17]
105883083  UDP-glucuronosyltransferase 2B31-like isoform X1 [KO:K00699] [EC:2.4.1.17]
105883084  UDP-glucuronosyltransferase 2B4-like isoform X1 [KO:K00699] [EC:2.4.1.17]
105883085  UDP-glucuronosyltransferase 2B31-like [KO:K00699] [EC:2.4.1.17]
105883086  UDP-glucuronosyltransferase 2B4-like [KO:K00699] [EC:2.4.1.17]
105869279  UDP-glucuronosyltransferase 2B7-like isoform X1 [KO:K00699] [EC:2.4.1.17]
105869299  UDP-glucuronosyltransferase 2B4-like isoform X3 [KO:K00699] [EC:2.4.1.17]
105869304  UDP-glucuronosyltransferase 2B31-like [KO:K00699] [EC:2.4.1.17]
105886128  UDP-glucuronosyltransferase 1-1-like isoform X1 [KO:K00699] [EC:2.4.1.17]
105886138  UDP-glucuronosyltransferase 1-8-like [KO:K00699] [EC:2.4.1.17]
105886140  UDP-glucuronosyltransferase 1-8-like [KO:K00699] [EC:2.4.1.17]
105886142  UDP-glucuronosyltransferase 1-3-like [KO:K00699] [EC:2.4.1.17]
105886143  UDP-glucuronosyltransferase 1-8-like [KO:K00699] [EC:2.4.1.17]
105886144  UDP-glucuronosyltransferase 1-8-like [KO:K00699] [EC:2.4.1.17]
109729189  UDP-glucuronosyltransferase 2B17-like [KO:K00699] [EC:2.4.1.17]
109729208  UDP-glucuronosyltransferase 2B4-like [KO:K00699] [EC:2.4.1.17]
109730987  UDP-glucuronosyltransferase 1-8-like [KO:K00699] [EC:2.4.1.17]
105864507  UDP-glucuronosyltransferase 2A1-like [KO:K00699] [EC:2.4.1.17]
105864508  UDP-glucuronosyltransferase 2A1 isoform X10 [KO:K00699] [EC:2.4.1.17]
105869127  cytochrome P450 2B6-like isoform X1 [KO:K17709] [EC:1.14.14.-]
105869130  cytochrome P450 2B6-like [KO:K17709] [EC:1.14.14.-]
105869132  cytochrome P450 2B4-like isoform X1 [KO:K17709] [EC:1.14.14.-]
105873551  NR1I3; nuclear receptor subfamily 1 group I member 3 isoform X1 [KO:K08541]
105880812  RXRA; retinoic acid receptor RXR-alpha isoform X1 [KO:K08524]
105885999  RXRB; retinoic acid receptor RXR-beta isoform X1 [KO:K08525]
105860510  RXRG; retinoic acid receptor RXR-gamma isoform X1 [KO:K08526]
105868328  cytochrome P450 3A4-like [KO:K17689] [EC:1.14.13.32 1.14.14.55 1.14.14.56 1.14.14.57 1.14.14.73 1.14.14.-]
105868331  cytochrome P450 3A4 [KO:K17689] [EC:1.14.13.32 1.14.14.55 1.14.14.56 1.14.14.57 1.14.14.73 1.14.14.-]
105868221  cytochrome P450 3A4-like isoform X1 [KO:K07424] [EC:1.14.14.1]
105868329  cytochrome P450 3A4-like [KO:K07424] [EC:1.14.14.1]
109729598  cytochrome P450 3A4-like [KO:K07424] [EC:1.14.14.1]
105854822  cytochrome P450 1A2-like [KO:K07409] [EC:1.14.14.1]
105867270  PPARA; peroxisome proliferator-activated receptor alpha isoform X1 [KO:K07294]
Compound
C00076  Calcium cation
C00410  Progesterone
C00547  L-Noradrenaline
C00575  3',5'-Cyclic AMP
C00745  Nicotine
C00780  Serotonin
C00788  L-Adrenaline
C00951  Estradiol-17beta
C03690  Bis(2-ethylhexyl)phthalate
C04623  DDT
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C06697  Arsenite
C06790  Trichloroethene
C06916  Clofibrate
C07020  Gemfibrozil
C07434  Phenobarbital
C07535  Benzo[a]pyrene
C07557  2,3,7,8-Tetrachlorodibenzodioxin
C08150  Medroxyprogesterone acetate
C11042  Hexachlorobenzene
C11150  Trichloroacetate
C11371  Nafenopin
C11906  Sodium arsenite
C13624  Bisphenol A
C14240  Di(2-ethylhexyl) adipate
C14573  3,3',4,4',5-Pentachlorobiphenyl
C15995  Bombesin
C16452  N'-Nitrosonornicotine
C16453  4-(N-Nitrosomethylamino)-1-(3-pyridyl)-1-butanone
Reference
PMID:15660110
  Authors
Luch A.
  Title
Nature and nurture - lessons from chemical carcinogenesis.
  Journal
Nat Rev Cancer 5:113-25 (2005)
DOI:10.1038/nrc1546
Reference
PMID:19631282
  Authors
Hernandez LG, van Steeg H, Luijten M, van Benthem J
  Title
Mechanisms of non-genotoxic carcinogens and importance of a weight of evidence approach.
  Journal
Mutat Res 682:94-109 (2009)
DOI:10.1016/j.mrrev.2009.07.002
Reference
PMID:21444681
  Authors
Wu CH, Lee CH, Ho YS
  Title
Nicotinic acetylcholine receptor-based blockade: applications of molecular targets for cancer therapy.
  Journal
Clin Cancer Res 17:3533-41 (2011)
DOI:10.1158/1078-0432.CCR-10-2434
Reference
PMID:19194381
  Authors
Schuller HM
  Title
Is cancer triggered by altered signalling of nicotinic acetylcholine receptors?
  Journal
Nat Rev Cancer 9:195-205 (2009)
DOI:10.1038/nrc2590
Reference
PMID:21541211
  Authors
Singh S, Pillai S, Chellappan S
  Title
Nicotinic acetylcholine receptor signaling in tumor growth and metastasis.
  Journal
J Oncol 2011:456743 (2011)
DOI:10.1155/2011/456743
Reference
PMID:31956359
  Authors
Cheng WL, Chen KY, Lee KY, Feng PH, Wu SM
  Title
Nicotinic-nAChR signaling mediates drug resistance in lung cancer.
  Journal
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Related
pathway
mmur00980  Metabolism of xenobiotics by cytochrome P450
mmur03320  PPAR signaling pathway
mmur04010  MAPK signaling pathway
mmur04024  cAMP signaling pathway
mmur04150  mTOR signaling pathway
mmur04151  PI3K-Akt signaling pathway
mmur04370  VEGF signaling pathway
mmur04915  Estrogen signaling pathway
mmur05204  Chemical carcinogenesis - DNA adducts
mmur05206  MicroRNAs in cancer
mmur05208  Chemical carcinogenesis - reactive oxygen species
KO pathway
ko05207   
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