KEGG   PATHWAY: myd05160
Entry
myd05160                    Pathway                                
Name
Hepatitis C - Myotis davidii (David's myotis)
Description
Hepatitis C virus (HCV) is a major cause of chronic liver disease. The HCV employ several strategies to perturb host cell immunity. After invasion, HCV RNA genome functions directly as an mRNA in the cytoplasm of the host cell and forms membrane-associated replication complexes along with non-structural proteins. Viral RNA can trigger the RIG-I pathway and interferon production during this process. Translated HCV protein products regulate immune response to inhibit the action of interferon. HCV core and NS5A proteins appear to be the most important molecules with regulatory functions that modulate transcription, cellular proliferation, and apoptosis.
Class
Human Diseases; Infectious disease: viral
Pathway map
myd05160  Hepatitis C
myd05160

Organism
Myotis davidii (David's myotis) [GN:myd]
Gene
102771350  LDLR; low density lipoprotein receptor [KO:K12473]
102763990  SCARB1; scavenger receptor class B member 1 [KO:K13885]
102757428  CD81; CD81 molecule [KO:K06508]
102767164  claudin-34-like [KO:K06087]
102767717  CLDN17; claudin 17 [KO:K06087]
102763351  CLDN10; claudin 10 [KO:K06087]
102771389  CLDN6; claudin 6 [KO:K06087]
102771684  CLDN9; claudin 9 [KO:K06087]
102758698  CLDN24; claudin 24 [KO:K06087]
102772039  CLDN22; claudin 22 [KO:K06087]
102760100  CLDN4; claudin 4 [KO:K06087]
102770512  CLDN15; claudin 15 [KO:K06087]
102766300  CLDN2; claudin 2 [KO:K06087]
102765067  CLDN14; claudin 14 [KO:K06087]
102769579  CLDN20; claudin 20 [KO:K06087]
102756017  CLDN18; claudin 18 [KO:K06087]
102764160  CLDN19; claudin 19 [KO:K06087]
102751606  CLDN7; claudin 7 [KO:K06087]
102772200  CLDN11; claudin 11 [KO:K06087]
102760064  CLDN1; claudin 1 [KO:K06087]
102760358  CLDN16; claudin 16 [KO:K06087]
102755287  CLDN5; claudin 5 [KO:K06087]
102762337  CLDN12; claudin 12 [KO:K06087]
107183096  CLDN34; claudin 34 [KO:K06087]
102766876  claudin-34-like [KO:K06087]
102772867  OCLN; occludin [KO:K06088]
102759968  OAS1; 2'-5'-oligoadenylate synthetase 1 [KO:K14216] [EC:2.7.7.84]
102756142  OAS3; 2'-5'-oligoadenylate synthetase 3 [KO:K14216] [EC:2.7.7.84]
102756409  OAS2; 2'-5'-oligoadenylate synthetase 2 [KO:K14216] [EC:2.7.7.84]
102754018  RNASEL; ribonuclease L [KO:K01165]
102751776  DDX58; DExD/H-box helicase 58 [KO:K12646] [EC:5.6.2.6]
102767843  MAVS; mitochondrial antiviral signaling protein [KO:K12648]
102771530  TRAF3; TNF receptor associated factor 3 [KO:K03174]
102769631  TBK1; TANK binding kinase 1 [KO:K05410] [EC:2.7.11.10]
102760291  IKBKE; inhibitor of nuclear factor kappa B kinase subunit epsilon [KO:K07211] [EC:2.7.11.10]
102760165  IRF3; interferon regulatory factor 3 [KO:K05411]
102766079  interferon alpha-1 [KO:K05414]
102765800  IFNB1; interferon beta 1 [KO:K05415]
102774208  IFNG; interferon gamma [KO:K04687]
102769140  TLR3; toll like receptor 3 [KO:K05401]
102754468  TICAM1; toll like receptor adaptor molecule 1 [KO:K05842]
102765934  TRAF6; TNF receptor associated factor 6 [KO:K03175] [EC:2.3.2.27]
102770973  RIPK1; receptor interacting serine/threonine kinase 1 [KO:K02861] [EC:2.7.11.1]
102760888  CHUK; conserved helix-loop-helix ubiquitous kinase [KO:K04467] [EC:2.7.11.10]
102773824  IKBKB; inhibitor of nuclear factor kappa B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
102772051  IKBKG; inhibitor of nuclear factor kappa B kinase subunit gamma [KO:K07210]
102763089  NFKBIA; NFKB inhibitor alpha [KO:K04734]
102770715  NFKB1; nuclear factor kappa B subunit 1 [KO:K02580]
102770704  RELA; RELA proto-oncogene, NF-kB subunit [KO:K04735]
102758774  TNF; tumor necrosis factor [KO:K03156]
102773477  CXCL10; C-X-C motif chemokine ligand 10 [KO:K12671]
102758379  EIF2AK1; eukaryotic translation initiation factor 2 alpha kinase 1 [KO:K16194] [EC:2.7.11.1]
102761664  EIF2AK4; eukaryotic translation initiation factor 2 alpha kinase 4 [KO:K16196] [EC:2.7.11.1]
102765635  EIF3E; eukaryotic translation initiation factor 3 subunit E [KO:K03250]
102767480  EIF2S1; eukaryotic translation initiation factor 2 subunit alpha [KO:K03237]
102752037  STAT3; signal transducer and activator of transcription 3 [KO:K04692]
102772617  IFNAR1; interferon alpha and beta receptor subunit 1 [KO:K05130]
102772901  IFNAR2; interferon alpha and beta receptor subunit 2 [KO:K05131]
102756517  JAK1; Janus kinase 1 [KO:K11217] [EC:2.7.10.2]
102751430  TYK2; tyrosine kinase 2 [KO:K11219] [EC:2.7.10.2]
102757059  STAT1; signal transducer and activator of transcription 1 [KO:K11220]
102766233  STAT2; signal transducer and activator of transcription 2 [KO:K11221]
102768335  IRF9; interferon regulatory factor 9 [KO:K04693]
102759139  MX1; MX dynamin like GTPase 1 [KO:K14754]
102758137  MX2; MX dynamin like GTPase 2 [KO:K14754]
102765979  RSAD2; radical S-adenosyl methionine domain containing 2 [KO:K15045]
102762854  PPP2R1A; protein phosphatase 2 scaffold subunit Aalpha [KO:K03456]
102758648  PPP2R1B; protein phosphatase 2 scaffold subunit Abeta [KO:K03456]
102773953  PPP2R2D; protein phosphatase 2 regulatory subunit Bdelta [KO:K04354]
102772844  PPP2R2B; protein phosphatase 2 regulatory subunit Bbeta [KO:K04354]
102756870  PPP2R2A; protein phosphatase 2 regulatory subunit Balpha [KO:K04354]
102774976  PPP2R2C; protein phosphatase 2 regulatory subunit Bgamma [KO:K04354]
102762679  PPP2CA; protein phosphatase 2 catalytic subunit alpha [KO:K04382] [EC:3.1.3.16]
102771922  PPP2CB; protein phosphatase 2 catalytic subunit beta [KO:K04382] [EC:3.1.3.16]
102755722  PIAS1; protein inhibitor of activated STAT 1 [KO:K04706] [EC:2.3.2.-]
102758044  EGF; epidermal growth factor [KO:K04357]
102775204  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
102754991  GRB2; growth factor receptor bound protein 2 [KO:K04364]
102768105  SOS1; SOS Ras/Rac guanine nucleotide exchange factor 1 [KO:K03099]
102763262  SOS2; SOS Ras/Rho guanine nucleotide exchange factor 2 [KO:K03099]
102762537  HRAS; HRas proto-oncogene, GTPase [KO:K02833]
102762284  KRAS; KRAS proto-oncogene, GTPase [KO:K07827]
102761492  NRAS; neuroblastoma RAS viral oncogene homolog [KO:K07828]
102760422  BRAF; B-Raf proto-oncogene, serine/threonine kinase [KO:K04365] [EC:2.7.11.1]
102772748  RAF1; Raf-1 proto-oncogene, serine/threonine kinase [KO:K04366] [EC:2.7.11.1]
102755690  ARAF; A-Raf proto-oncogene, serine/threonine kinase [KO:K08845] [EC:2.7.11.1]
102765745  14-3-3 protein theta-like [KO:K16197]
102765675  YWHAZ; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta [KO:K16197]
102763310  YWHAB; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta [KO:K16197]
102767684  YWHAQ; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta [KO:K16197]
102757913  YWHAE; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon [KO:K06630]
102766115  YWHAG; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma [KO:K16198]
102756859  YWHAH; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta [KO:K16198]
102763997  MAP2K1; mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
102757282  MAP2K2; mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
102769037  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
102775211  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
102763670  PIK3R2; phosphoinositide-3-kinase regulatory subunit 2 [KO:K02649]
102753036  PIK3R1; phosphoinositide-3-kinase regulatory subunit 1 [KO:K02649]
102760468  PIK3R3; phosphoinositide-3-kinase regulatory subunit 3 [KO:K02649]
102764343  PIK3CB; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta [KO:K00922] [EC:2.7.1.153]
102766356  PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta [KO:K00922] [EC:2.7.1.153]
102758951  PIK3CA; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha [KO:K00922] [EC:2.7.1.153]
102772266  AKT3; AKT serine/threonine kinase 3 [KO:K04456] [EC:2.7.11.1]
102773065  AKT2; AKT serine/threonine kinase 2 [KO:K04456] [EC:2.7.11.1]
102751662  GSK3B; glycogen synthase kinase 3 beta [KO:K03083] [EC:2.7.11.26]
102773658  CTNNB1; catenin beta 1 [KO:K02105]
102771665  BAD; BCL2 associated agonist of cell death [KO:K02158]
102773038  CDKN1A; cyclin dependent kinase inhibitor 1A [KO:K06625]
102759012  TP53; tumor protein p53 [KO:K04451]
102756838  CDK2; cyclin dependent kinase 2 [KO:K02206] [EC:2.7.11.22]
102758995  CDK4; cyclin dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
102760528  CDK6; cyclin dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
102766251  RB1; RB transcriptional corepressor 1 [KO:K06618]
102759026  E2F1; E2F transcription factor 1 [KO:K17454]
102755439  E2F2; E2F transcription factor 2 [KO:K09389]
102768307  E2F3; E2F transcription factor 3 [KO:K06620]
102768884  TNFRSF1A; TNF receptor superfamily member 1A [KO:K03158]
102757347  TRADD; TNFRSF1A associated via death domain [KO:K03171]
102772361  TRAF2; TNF receptor associated factor 2 [KO:K03173] [EC:2.3.2.27]
102759597  FASLG; Fas ligand [KO:K04389]
102760302  FAS; Fas cell surface death receptor [KO:K04390]
102756704  FADD; Fas associated via death domain [KO:K02373]
102761550  CASP8; caspase 8 [KO:K04398] [EC:3.4.22.61]
102760961  CASP3; caspase 3 [KO:K02187] [EC:3.4.22.56]
102763362  CFLAR; CASP8 and FADD like apoptosis regulator [KO:K04724]
102751916  BID; BH3 interacting domain death agonist [KO:K04726]
102761803  BAX; BCL2 associated X, apoptosis regulator [KO:K02159]
102764949  BAK1; BCL2 antagonist/killer 1 [KO:K14021]
102774832  cytochrome c-like [KO:K08738]
102771029  cytochrome c-like [KO:K08738]
102752458  cytochrome c [KO:K08738]
102759877  cytochrome c [KO:K08738]
102773861  APAF1; apoptotic peptidase activating factor 1 [KO:K02084]
102759481  CASP9; caspase 9 [KO:K04399] [EC:3.4.22.62]
102757857  PSME3; proteasome activator subunit 3 [KO:K06698]
102762226  RXRA; retinoid X receptor alpha [KO:K08524]
102773112  PPARA; peroxisome proliferator activated receptor alpha [KO:K07294]
102755020  NR1H3; nuclear receptor subfamily 1 group H member 3 [KO:K08536]
102759793  CCND1; cyclin D1 [KO:K04503]
102758544  MYC; v-myc avian myelocytomatosis viral oncogene homolog [KO:K04377]
Compound
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C20935  2-5A
Reference
PMID:24520529
  Authors
Hassan M, Selimovic D, El-Khattouti A, Ghozlan H, Haikel Y, Abdelkader O
  Title
Hepatitis C virus-host interactions: Etiopathogenesis and therapeutic strategies.
  Journal
World J Exp Med 2:7-25 (2012)
DOI:10.5493/wjem.v2.i2.7
Reference
PMID:23641066
  Authors
Yamauchi Y, Helenius A
  Title
Virus entry at a glance.
  Journal
J Cell Sci 126:1289-95 (2013)
DOI:10.1242/jcs.119685
Reference
PMID:24509809
  Authors
Feneant L, Levy S, Cocquerel L
  Title
CD81 and hepatitis C virus (HCV) infection.
  Journal
Viruses 6:535-72 (2014)
DOI:10.3390/v6020535
Reference
PMID:18081727
  Authors
Dubuisson J, Helle F, Cocquerel L
  Title
Early steps of the hepatitis C virus life cycle.
  Journal
Cell Microbiol 10:821-7 (2008)
DOI:10.1111/j.1462-5822.2007.01107.x
Reference
PMID:23675659
  Authors
Liang TJ, Ghany MG
  Title
Current and future therapies for hepatitis C virus infection.
  Journal
N Engl J Med 368:1907-17 (2013)
DOI:10.1056/NEJMra1213651
Reference
PMID:23836234
  Authors
Scheel TK, Rice CM
  Title
Understanding the hepatitis C virus life cycle paves the way for highly effective therapies.
  Journal
Nat Med 19:837-49 (2013)
DOI:10.1038/nm.3248
Reference
PMID:26586968
  Authors
Holmes JA, Thompson AJ
  Title
Interferon-free combination therapies for the treatment of hepatitis C: current insights.
  Journal
Hepat Med 7:51-70 (2015)
DOI:10.2147/HMER.S55864
Reference
PMID:15039538
  Authors
Taguchi T, Nagano-Fujii M, Akutsu M, Kadoya H, Ohgimoto S, Ishido S, Hotta H
  Title
Hepatitis C virus NS5A protein interacts with 2',5'-oligoadenylate synthetase and inhibits antiviral activity of IFN in an IFN sensitivity-determining region-independent manner.
  Journal
J Gen Virol 85:959-69 (2004)
DOI:10.1099/vir.0.19513-0
Reference
PMID:19708811
  Authors
Horner SM, Gale M Jr
  Title
Intracellular innate immune cascades and interferon defenses that control hepatitis C virus.
  Journal
J Interferon Cytokine Res 29:489-98 (2009)
DOI:10.1089/jir.2009.0063
Reference
PMID:20457596
  Authors
Lemon SM
  Title
Induction and evasion of innate antiviral responses by hepatitis C virus.
  Journal
J Biol Chem 285:22741-7 (2010)
DOI:10.1074/jbc.R109.099556
Reference
PMID:23836238
  Authors
Horner SM, Gale M Jr
  Title
Regulation of hepatic innate immunity by hepatitis C virus.
  Journal
Nat Med 19:879-88 (2013)
DOI:10.1038/nm.3253
Reference
PMID:28862649
  Authors
Ortega-Prieto AM, Dorner M
  Title
Immune Evasion Strategies during Chronic Hepatitis B and C Virus Infection.
  Journal
Vaccines (Basel) 5:E24 (2017)
DOI:10.3390/vaccines5030024
Reference
PMID:25852264
  Authors
Yang DR, Zhu HZ
  Title
Hepatitis C virus and antiviral innate immunity: who wins at tug-of-war?
  Journal
World J Gastroenterol 21:3786-800 (2015)
DOI:10.3748/wjg.v21.i13.3786
Reference
PMID:16107833
  Authors
Gale M Jr, Foy EM
  Title
Evasion of intracellular host defence by hepatitis C virus.
  Journal
Nature 436:939-45 (2005)
DOI:10.1038/nature04078
Reference
PMID:17467654
  Authors
Bode JG, Brenndorfer ED, Haussinger D
  Title
Subversion of innate host antiviral strategies by the hepatitis C virus.
  Journal
Arch Biochem Biophys 462:254-65 (2007)
DOI:10.1016/j.abb.2007.03.033
Reference
PMID:12686421
  Authors
Panteva M, Korkaya H, Jameel S
  Title
Hepatitis viruses and the MAPK pathway: is this a survival strategy?
  Journal
Virus Res 92:131-40 (2003)
DOI:10.1016/S0168-1702(02)00356-8
Reference
PMID:16239065
  Authors
Pang R, Tse E, Poon RT
  Title
Molecular pathways in hepatocellular carcinoma.
  Journal
Cancer Lett 240:157-69 (2006)
DOI:10.1016/j.canlet.2005.08.031
Reference
PMID:15302943
  Authors
Macdonald A, Harris M
  Title
Hepatitis C virus NS5A: tales of a promiscuous protein.
  Journal
J Gen Virol 85:2485-502 (2004)
DOI:10.1099/vir.0.80204-0
Reference
PMID:21250384
  Authors
He Y, Staschke KA, Tan SL
  Title
HCV NS5A: A Multifunctional Regulator of Cellular Pathways and Virus Replication
  Journal
Hepatitis C Viruses: Genomes and Molecular Biology (2006)
Reference
PMID:12101418
  Authors
Lan KH, Sheu ML, Hwang SJ, Yen SH, Chen SY, Wu JC, Wang YJ, Kato N, Omata M, Chang FY, Lee SD
  Title
HCV NS5A interacts with p53 and inhibits p53-mediated apoptosis.
  Journal
Oncogene 21:4801-11 (2002)
DOI:10.1038/sj.onc.1205589
Reference
PMID:11886269
  Authors
Majumder M, Ghosh AK, Steele R, Zhou XY, Phillips NJ, Ray R, Ray RB
  Title
Hepatitis C virus NS5A protein impairs TNF-mediated hepatic apoptosis, but not by an anti-FAS antibody, in transgenic mice.
  Journal
Virology 294:94-105 (2002)
DOI:10.1006/viro.2001.1309
Reference
PMID:15381253
  Authors
Hassan M, Ghozlan H, Abdel-Kader O
  Title
Activation of RB/E2F signaling pathway is required for the modulation of hepatitis C virus core protein-induced cell growth in liver and non-liver cells.
  Journal
Cell Signal 16:1375-85 (2004)
DOI:10.1016/j.cellsig.2004.04.005
Reference
PMID:11514734
  Authors
Kwun HJ, Jung EY, Ahn JY, Lee MN, Jang KL
  Title
p53-dependent transcriptional repression of p21(waf1) by hepatitis C virus NS3.
  Journal
J Gen Virol 82:2235-41 (2001)
DOI:10.1099/0022-1317-82-9-2235
Reference
PMID:12056797
  Authors
Yamanaka T, Uchida M, Doi T
  Title
Innate form of HCV core protein plays an important role in the localization and the function of HCV core protein.
  Journal
Biochem Biophys Res Commun 294:521-7 (2002)
DOI:10.1016/S0006-291X(02)00507-7
Reference
PMID:22611309
  Authors
Lim EJ, Chin R, Angus PW, Torresi J
  Title
Enhanced apoptosis in post-liver transplant hepatitis C: effects of virus and immunosuppressants.
  Journal
World J Gastroenterol 18:2172-9 (2012)
DOI:10.3748/wjg.v18.i18.2172
Reference
PMID:17828818
  Authors
Fischer R, Baumert T, Blum HE
  Title
Hepatitis C virus infection and apoptosis.
  Journal
World J Gastroenterol 13:4865-72 (2007)
DOI:10.3748/wjg.v13.i36.4865
Reference
PMID:16611896
  Authors
Saito K, Meyer K, Warner R, Basu A, Ray RB, Ray R
  Title
Hepatitis C virus core protein inhibits tumor necrosis factor alpha-mediated apoptosis by a protective effect involving cellular FLICE inhibitory protein.
  Journal
J Virol 80:4372-9 (2006)
DOI:10.1128/JVI.80.9.4372-4379.2006
Reference
PMID:19148799
  Authors
Koike K
  Title
Steatosis, liver injury, and hepatocarcinogenesis in hepatitis C viral infection.
  Journal
J Gastroenterol 44 Suppl 19:82-8 (2009)
DOI:10.1007/s00535-008-2276-4
Reference
PMID:17764115
  Authors
Tanaka N, Moriya K, Kiyosawa K, Koike K, Aoyama T
  Title
Hepatitis C virus core protein induces spontaneous and persistent activation of peroxisome proliferator-activated receptor alpha in transgenic mice: implications for HCV-associated hepatocarcinogenesis.
  Journal
Int J Cancer 122:124-31 (2008)
DOI:10.1002/ijc.23056
Reference
PMID:18251977
  Authors
Tan A, Yeh SH, Liu CJ, Cheung C, Chen PJ
  Title
Viral hepatocarcinogenesis: from infection to cancer.
  Journal
Liver Int 28:175-88 (2008)
DOI:10.1111/j.1478-3231.2007.01652.x
Related
pathway
myd03320  PPAR signaling pathway
myd04010  MAPK signaling pathway
myd04144  Endocytosis
myd04210  Apoptosis
myd04514  Cell adhesion molecules
myd04620  Toll-like receptor signaling pathway
myd04622  RIG-I-like receptor signaling pathway
myd04630  JAK-STAT signaling pathway
myd04668  TNF signaling pathway
KO pathway
ko05160   
LinkDB

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