KEGG   PATHWAY: nni04510
Entry
nni04510                    Pathway                                
Name
Focal adhesion - Nipponia nippon (crested ibis)
Description
Cell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the cell-extracellular matrix contact points, specialized structures are formed and termed focal adhesions, where bundles of actin filaments are anchored to transmembrane receptors of the integrin family through a multi-molecular complex of junctional plaque proteins. Some of the constituents of focal adhesions participate in the structural link between membrane receptors and the actin cytoskeleton, while others are signalling molecules, including different protein kinases and phosphatases, their substrates, and various adapter proteins. Integrin signaling is dependent upon the non-receptor tyrosine kinase activities of the FAK and src proteins as well as the adaptor protein functions of FAK, src and Shc to initiate downstream signaling events. These signalling events culminate in reorganization of the actin cytoskeleton; a prerequisite for changes in cell shape and motility, and gene expression. Similar morphological alterations and modulation of gene expression are initiated by the binding of growth factors to their respective receptors, emphasizing the considerable crosstalk between adhesion- and growth factor-mediated signalling.
Class
Cellular Processes; Cellular community - eukaryotes
Pathway map
nni04510  Focal adhesion
nni04510

Other DBs
GO: 0005925
Organism
Nipponia nippon (crested ibis) [GN:nni]
Gene
104014017  COL1A2; collagen alpha-2(I) chain [KO:K06236]
104012250  COL1A1; collagen alpha-1(I) chain [KO:K06236]
104017542  COL2A1; collagen alpha-1(II) chain [KO:K19719]
104016493  COL4A3; collagen alpha-3(IV) chain [KO:K06237]
104016495  COL4A4; LOW QUALITY PROTEIN: collagen alpha-4(IV) chain [KO:K06237]
104023605  COL4A5; collagen alpha-5(IV) chain [KO:K06237]
104023616  COL4A6; collagen alpha-6(IV) chain [KO:K06237]
104012564  COL4A1; collagen alpha-1(IV) chain [KO:K06237]
104012565  COL4A2; LOW QUALITY PROTEIN: collagen alpha-2(IV) chain [KO:K06237]
104009985  COL6A3; collagen alpha-3(VI) chain [KO:K06238]
104018487  COL6A6; LOW QUALITY PROTEIN: collagen alpha-6(VI) chain [KO:K06238]
104018488  LOW QUALITY PROTEIN: collagen alpha-4(VI) chain-like [KO:K06238]
104009120  COL6A2; collagen alpha-2(VI) chain [KO:K06238]
104009122  COL6A1; collagen alpha-1(VI) chain [KO:K06238]
104017777  COL9A2; collagen alpha-2(IX) chain [KO:K08131]
104009611  COL9A3; collagen alpha-3(IX) chain [KO:K08131]
104021992  COL9A1; collagen alpha-1(IX) chain [KO:K08131]
104017673  LAMA1; LOW QUALITY PROTEIN: laminin subunit alpha-1 [KO:K05637]
104008903  LAMA2; laminin subunit alpha-2 [KO:K05637]
104009577  LAMA5; laminin subunit alpha-5 [KO:K06240]
104018154  LAMA3; laminin subunit alpha-3 [KO:K06240]
104011135  LAMA4; laminin subunit alpha-4 [KO:K06241]
104010798  LAMB1; laminin subunit beta-1 [KO:K05636]
104016978  LAMB2; laminin subunit beta-2 [KO:K06243]
104010308  LAMB3; laminin subunit beta-3 [KO:K06244]
104010797  LAMB4; LOW QUALITY PROTEIN: laminin subunit beta-4 [KO:K06245]
104011351  LAMC1; laminin subunit gamma-1 [KO:K05635]
104011320  LAMC2; laminin subunit gamma-2 [KO:K06246]
104023271  LAMC3; laminin subunit gamma-3 [KO:K06247]
104020684  CHAD; chondroadherin [KO:K06248]
104010809  RELN; reelin [KO:K06249] [EC:3.4.21.-]
104020294  THBS1; thrombospondin-1 [KO:K16857]
104013690  COMP; cartilage oligomeric matrix protein [KO:K04659]
104017909  THBS2; thrombospondin-2 [KO:K04659]
104009111  THBS4; thrombospondin-4 [KO:K04659]
104020504  THBS3; thrombospondin-3 [KO:K04659]
104010144  FN1; fibronectin [KO:K05717]
104014966  SPP1; osteopontin [KO:K06250]
104012759  VTN; vitronectin [KO:K06251]
104011328  TNN; tenascin-N [KO:K06252]
104011331  TNR; tenascin-R isoform X1 [KO:K06252]
104022152  TNC; tenascin [KO:K06252]
104021755  VWF; von Willebrand factor [KO:K03900]
104015014  IBSP; bone sialoprotein 2 [KO:K06253]
104008507  ITGA1; integrin alpha-1 [KO:K06480]
104012504  ITGA2; integrin alpha-2 [KO:K06481]
104018919  ITGA2B; integrin alpha-IIb [KO:K06476]
104012301  ITGA3; integrin alpha-3 [KO:K06482]
104010282  ITGA4; integrin alpha-4 [KO:K06483]
104010032  ITGA6; integrin alpha-6 [KO:K06485]
104013324  ITGA8; integrin alpha-8 [KO:K06584]
104018657  ITGA9; integrin alpha-9 [KO:K06585]
104014465  ITGA10; integrin alpha-10 [KO:K06586]
104017039  ITGA11; integrin alpha-11 [KO:K06587]
104015304  ITGAV; integrin alpha-V [KO:K06487]
104022255  ITGB1; integrin beta-1 [KO:K05719]
104009899  ITGB3; integrin beta-3 [KO:K06493]
104022852  ITGB4; integrin beta-4 [KO:K06525]
104018787  ITGB5; integrin beta-5 [KO:K06588]
104010043  ITGB6; integrin beta-6 isoform X1 [KO:K06589]
104013946  ITGB8; integrin beta-8 [KO:K06591]
104023445  EMP2; epithelial membrane protein 2 [KO:K26256]
104015206  PDGFA; platelet-derived growth factor subunit A [KO:K04359]
104021619  PDGFB; platelet-derived growth factor subunit B [KO:K17386]
104023065  PDGFD; platelet-derived growth factor D [KO:K05450]
104021357  PDGFC; platelet-derived growth factor C [KO:K05450]
104021157  EGF; pro-epidermal growth factor [KO:K04357]
104013358  IGF1; insulin-like growth factor I [KO:K05459]
104018695  VEGFA; vascular endothelial growth factor A [KO:K05448]
104021035  PGF; placenta growth factor [KO:K16859]
104021276  VEGFC; vascular endothelial growth factor C isoform X1 [KO:K05449]
104022532  FIGF; vascular endothelial growth factor D [KO:K05449]
104010752  HGF; hepatocyte growth factor [KO:K05460]
104020776  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
104014196  PDGFRB; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
104017228  IGF1R; insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
104020821  KDR; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
104012443  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
104023019  FLT1; LOW QUALITY PROTEIN: vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
104021082  vascular endothelial growth factor receptor kdr-like [KO:K05096] [EC:2.7.10.1]
104014191  FLT4; vascular endothelial growth factor receptor 3 [KO:K05097] [EC:2.7.10.1]
104013588  MET; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
104013874  ERBB2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
104021667  EMP1; epithelial membrane protein 1 [KO:K26255]
104009559  SRC; proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
104012641  ARHGAP35; rho GTPase-activating protein 35 [KO:K05732]
104011787  ARHGAP5; rho GTPase-activating protein 5 [KO:K13709]
104008684  RHOA; transforming protein RhoA [KO:K04513]
104018128  ROCK1; rho-associated protein kinase 1 [KO:K04514] [EC:2.7.11.1]
104013015  ROCK2; LOW QUALITY PROTEIN: rho-associated protein kinase 2 [KO:K17388] [EC:2.7.11.1]
104019401  MYL2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
104022604  MYL7; myosin regulatory light chain 2, atrial isoform [KO:K12754]
104019952  MYL9; myosin regulatory light polypeptide 9 isoform X1 [KO:K12755]
104016106  MYL10; myosin regulatory light chain 10 [KO:K12756]
104017681  myosin regulatory light chain 2, smooth muscle minor isoform isoform X1 [KO:K12757]
104015764  myosin regulatory light chain 2, smooth muscle minor isoform isoform X1 [KO:K12757]
104011867  PPP1CA; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
104021492  PPP1CB; LOW QUALITY PROTEIN: serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
104020653  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
104010975  PPP1R12A; protein phosphatase 1 regulatory subunit 12A isoform X1 [KO:K06270]
104011079  protein phosphatase 1 regulatory subunit 12B-like [KO:K12329]
104018914  myosin light chain kinase, smooth muscle-like [KO:K00907] [EC:2.7.11.18]
104011279  MYLK3; myosin light chain kinase 3 [KO:K00907] [EC:2.7.11.18]
104018366  MYLK2; myosin light chain kinase 2, skeletal/cardiac muscle [KO:K00907] [EC:2.7.11.18]
104018798  MYLK; myosin light chain kinase, smooth muscle isoform X1 [KO:K00907] [EC:2.7.11.18]
104021845  MYLK4; myosin light chain kinase family member 4 [KO:K00907] [EC:2.7.11.18]
104014454  PIP5K1A; phosphatidylinositol 4-phosphate 5-kinase type-1 alpha [KO:K00889] [EC:2.7.1.68]
104008676  PIP5K1B; phosphatidylinositol 4-phosphate 5-kinase type-1 beta [KO:K00889] [EC:2.7.1.68]
104019631  PIP5K1C; phosphatidylinositol 4-phosphate 5-kinase type-1 gamma [KO:K00889] [EC:2.7.1.68]
104016716  actin, cytoplasmic type 5 isoform X1 [KO:K05692]
104014277  ACTG1; actin, cytoplasmic 2 isoform X1 [KO:K05692]
104015100  ACTB; actin, cytoplasmic 1 isoform X1 [KO:K05692]
104017026  RASGRF1; ras-specific guanine nucleotide-releasing factor 1 [KO:K04349]
104019299  CAPN2; calpain-2 catalytic subunit [KO:K03853] [EC:3.4.22.53]
104020309  ACTN1; alpha-actinin-1 isoform X1 [KO:K05699]
104017281  ACTN4; alpha-actinin-4 isoform X1 [KO:K05699]
104015316  LOW QUALITY PROTEIN: talin-1-like [KO:K06271]
104018465  LOW QUALITY PROTEIN: talin-1-like [KO:K06271]
104016752  TLN2; talin-2 [KO:K06271]
104019559  LOW QUALITY PROTEIN: filamin-A-like [KO:K04437]
104022661  FLNB; filamin-B isoform X1 [KO:K27392]
104011506  paxillin-like [KO:K05760]
104014876  ILK; integrin-linked protein kinase [KO:K06272] [EC:2.7.11.1]
104009556  ZYX; zyxin [KO:K06273]
104020126  VCL; vinculin [KO:K05700]
104012672  PARVG; gamma-parvin [KO:K06275]
104012673  PARVB; beta-parvin isoform X1 [KO:K06275]
104009521  PARVA; alpha-parvin [KO:K06275]
104015160  PDPK1; 3-phosphoinositide-dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
104020263  AKT2; LOW QUALITY PROTEIN: RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
104014534  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
104011272  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
104008666  GSK3B; glycogen synthase kinase-3 beta [KO:K03083] [EC:2.7.11.26]
104012111  CTNNB1; catenin beta-1 [KO:K02105]
104014361  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
104015276  PRKCB; protein kinase C beta type [KO:K19662] [EC:2.7.11.13]
104020584  PTK2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
104008980  PIK3CD; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
104023668  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
104019595  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
104015409  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
104018715  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta isoform X1 [KO:K02649]
104013521  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
104014964  VAV1; proto-oncogene vav [KO:K05730]
104017634  VAV3; guanine nucleotide exchange factor VAV3 [KO:K05730]
104023288  VAV2; guanine nucleotide exchange factor VAV2 [KO:K05730]
104015059  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
104021590  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
104014320  RAC3; ras-related C3 botulinum toxin substrate 3 [KO:K07861]
104022736  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
104010637  PAK2; serine/threonine-protein kinase PAK 2 isoform X1 [KO:K04410] [EC:2.7.11.1]
104023254  PAK3; serine/threonine-protein kinase PAK 3 isoform X1 [KO:K05733] [EC:2.7.11.1]
104017286  PAK4; serine/threonine-protein kinase PAK 4 [KO:K05734] [EC:2.7.11.1]
104022435  PAK7; serine/threonine-protein kinase PAK 7 [KO:K05736] [EC:2.7.11.1]
104020526  PAK6; serine/threonine-protein kinase PAK 6 isoform X1 [KO:K05735] [EC:2.7.11.1]
104011199  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
104016382  BCAR1; breast cancer anti-estrogen resistance protein 1 [KO:K05726]
104011434  CRKL; crk-like protein [KO:K04438]
104016008  CRK; adapter molecule crk [KO:K04438]
104022104  DOCK1; dedicator of cytokinesis protein 1 [KO:K13708]
104023176  RAPGEF1; rap guanine nucleotide exchange factor 1 [KO:K06277]
104010315  RAP1A; LOW QUALITY PROTEIN: ras-related protein Rap-1A [KO:K04353]
104011007  RAP1B; ras-related protein Rap-1b [KO:K07836]
104018444  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
104013238  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
104019815  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
104009262  JUN; transcription factor AP-1 isoform X1 [KO:K04448]
104012385  BRAF; serine/threonine-protein kinase B-raf [KO:K04365] [EC:2.7.11.1]
104013626  CAV1; caveolin-1 [KO:K06278]
104013627  CAV2; caveolin-2 [KO:K12958]
104016951  CAV3; caveolin-3 [KO:K12959]
104011133  FYN; tyrosine-protein kinase Fyn isoform X1 [KO:K05703] [EC:2.7.10.2]
104012052  SHC1; SHC-transforming protein 1 [KO:K06279]
104016320  SHC2; SHC-transforming protein 2 [KO:K17447]
104009737  SHC3; SHC-transforming protein 3 [KO:K17448]
104017130  SHC4; LOW QUALITY PROTEIN: SHC-transforming protein 4 [KO:K17449]
104020665  GRB2; growth factor receptor-bound protein 2 isoform X1 [KO:K04364]
104022133  SOS1; son of sevenless homolog 1 [KO:K03099]
104019491  SOS2; son of sevenless homolog 2 [KO:K03099]
104017304  HRAS; GTPase HRas [KO:K02833]
104022929  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
104017047  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
104020099  MAPK1; LOW QUALITY PROTEIN: mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
104009408  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
104021822  CCND2; G1/S-specific cyclin-D2 isoform X1 [KO:K10151]
104013148  CCND3; G1/S-specific cyclin-D3 [KO:K10152]
104023072  BIRC2; baculoviral IAP repeat-containing protein 2 [KO:K16060]
104023425  XIAP; LOW QUALITY PROTEIN: E3 ubiquitin-protein ligase XIAP [KO:K04725] [EC:2.3.2.27]
104021857  BCL2; apoptosis regulator Bcl-2 [KO:K02161]
Compound
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:14756624
  Authors
Berman AE, Kozlova NI, Morozevich GE.
  Title
Integrins: structure and signaling.
  Journal
Biochemistry (Mosc) 68:1284-99 (2003)
DOI:10.1023/b:biry.0000011649.03634.74
Reference
PMID:15179030
  Authors
Lee JW, Juliano R.
  Title
Mitogenic signal transduction by integrin- and growth factor receptor-mediated pathways.
  Journal
Mol Cells 17:188-202 (2004)
Reference
PMID:11573199
  Authors
Danen EH, Yamada KM.
  Title
Fibronectin, integrins, and growth control.
  Journal
J Cell Physiol 189:1-13 (2001)
DOI:10.1002/jcp.1137
Reference
PMID:15459662
  Authors
Guo W, Giancotti FG.
  Title
Integrin signalling during tumour progression.
  Journal
Nat Rev Mol Cell Biol 5:816-26 (2004)
DOI:10.1038/nrm1490
Reference
PMID:11229600
  Authors
Petit V, Thiery JP.
  Title
Focal adhesions: structure and dynamics.
  Journal
Biol Cell 92:477-94 (2000)
DOI:10.1016/S0248-4900(00)01101-1
Reference
PMID:12235283
  Authors
Stupack DG, Cheresh DA.
  Title
Get a ligand, get a life: integrins, signaling and cell survival.
  Journal
J Cell Sci 115:3729-38 (2002)
DOI:10.1242/jcs.00071
Reference
PMID:12640026
  Authors
Parsons JT.
  Title
Focal adhesion kinase: the first ten years.
  Journal
J Cell Sci 116:1409-16 (2003)
DOI:10.1242/jcs.00373
Reference
PMID:15688067
  Authors
Mitra SK, Hanson DA, Schlaepfer DD.
  Title
Focal adhesion kinase: in command and control of cell motility.
  Journal
Nat Rev Mol Cell Biol 6:56-68 (2005)
DOI:10.1038/nrm1549
Reference
PMID:14519391
  Authors
Comoglio PM, Boccaccio C, Trusolino L.
  Title
Interactions between growth factor receptors and adhesion molecules: breaking the rules.
  Journal
Curr Opin Cell Biol 15:565-71 (2003)
DOI:10.1016/S0955-0674(03)00096-6
Reference
PMID:15108811
  Authors
Schlaepfer DD, Mitra SK.
  Title
Multiple connections link FAK to cell motility and invasion.
  Journal
Curr Opin Genet Dev 14:92-101 (2004)
DOI:10.1016/j.gde.2003.12.002
Reference
PMID:14744429
  Authors
Burridge K, Wennerberg K.
  Title
Rho and Rac take center stage.
  Journal
Cell 116:167-79 (2004)
DOI:10.1016/S0092-8674(04)00003-0
Reference
PMID:11082269
  Authors
Schmitz AA, Govek EE, Bottner B, Van Aelst L.
  Title
Rho GTPases: signaling, migration, and invasion.
  Journal
Exp Cell Res 261:1-12 (2000)
DOI:10.1006/excr.2000.5049
Reference
PMID:10698680
  Authors
Vanhaesebroeck B, Alessi DR.
  Title
The PI3K-PDK1 connection: more than just a road to PKB.
  Journal
Biochem J 346 Pt 3:561-76 (2000)
DOI:10.1042/bj3460561
Reference
PMID:11882383
  Authors
Nicholson KM, Anderson NG.
  Title
The protein kinase B/Akt signalling pathway in human malignancy.
  Journal
Cell Signal 14:381-95 (2002)
DOI:10.1016/S0898-6568(01)00271-6
Reference
PMID:15053919
  Authors
Oloumi A, McPhee T, Dedhar S.
  Title
Regulation of E-cadherin expression and beta-catenin/Tcf transcriptional activity by the integrin-linked kinase.
  Journal
Biochim Biophys Acta 1691:1-15 (2004)
DOI:10.1016/j.bbamcr.2003.12.002
Reference
PMID:11146675
  Authors
Turner CE.
  Title
Paxillin and focal adhesion signalling.
  Journal
Nat Cell Biol 2:E231-6 (2000)
DOI:10.1038/35046659
Reference
PMID:15034601
  Authors
Hlobilkova A, Knillova J, Bartek J, Lukas J, Kolar Z.
  Title
The mechanism of action of the tumour suppressor gene PTEN.
  Journal
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 147:19-25 (2003)
Related
pathway
nni04010  MAPK signaling pathway
nni04060  Cytokine-cytokine receptor interaction
nni04070  Phosphatidylinositol signaling system
nni04110  Cell cycle
nni04310  Wnt signaling pathway
nni04512  ECM-receptor interaction
nni04810  Regulation of actin cytoskeleton
KO pathway
ko04510   
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