KEGG   PATHWAY: ogo04140
Entry
ogo04140                    Pathway                                
Name
Autophagy - animal - Oncorhynchus gorbuscha (pink salmon)
Description
Autophagy (or macroautophagy) is a cellular catabolic pathway involving in protein degradation, organelle turnover, and non-selective breakdown of cytoplasmic components, which is evolutionarily conserved among eukaryotes and exquisitely regulated. This progress initiates with production of the autophagosome, a double-membrane intracellular structure of reticular origin that engulfs cytoplasmic contents and ultimately fuses with lysosomes for cargo degradation. Autophagy is regulated in response to extra- or intracellular stress and signals such as starvation, growth factor deprivation and ER stress. Constitutive level of autophagy plays an important role in cellular homeostasis and maintains quality control of essential cellular components.
Class
Cellular Processes; Transport and catabolism
Pathway map
ogo04140  Autophagy - animal
ogo04140

Other DBs
GO: 0006914
Organism
Oncorhynchus gorbuscha (pink salmon) [GN:ogo]
Gene
123995144  insulin-like [KO:K04526]
124000570  insulin [KO:K04526]
124036813  igf1ra; insulin-like growth factor 1a receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
124000795  insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
123994816  irs1; insulin receptor substrate 1-B isoform X1 [KO:K16172]
124009869  insulin receptor substrate 1-B-like [KO:K16172]
124000899  insulin receptor substrate 1-B-like [KO:K16172]
124008927  si:ch73-335l21.1; insulin receptor substrate 1 isoform X1 [KO:K16172]
124013757  insulin receptor substrate 2-B-like [KO:K07187]
124006799  insulin receptor substrate 2-B-like [KO:K07187]
124044147  LOW QUALITY PROTEIN: insulin receptor substrate 2-like [KO:K07187]
124045618  LOW QUALITY PROTEIN: insulin receptor substrate 2-like [KO:K07187]
124008468  insulin receptor substrate 1-like [KO:K07187]
124008660  insulin receptor substrate 2-like [KO:K07187]
123996907  pik3ca; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
123992583  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform-like [KO:K00922] [EC:2.7.1.153]
124010063  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform-like [KO:K00922] [EC:2.7.1.153]
124042084  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform-like [KO:K00922] [EC:2.7.1.153]
124005461  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform-like [KO:K00922] [EC:2.7.1.153]
124014278  zgc:158659; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
124031982  pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
123996633  phosphatidylinositol 3-kinase regulatory subunit gamma-like [KO:K02649]
124010044  phosphatidylinositol 3-kinase regulatory subunit gamma-like [KO:K02649]
124033975  phosphatidylinositol 3-kinase regulatory subunit alpha-like [KO:K02649]
124049061  pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
124041705  phosphatidylinositol 3-kinase regulatory subunit gamma-like [KO:K02649]
123997852  phosphatidylinositol 3-kinase regulatory subunit beta-like isoform X1 [KO:K02649]
123998115  phosphatidylinositol 3-kinase regulatory subunit gamma-like isoform X1 [KO:K02649]
124042011  phosphatidylinositol 3-kinase regulatory subunit gamma-like [KO:K02649]
124006681  phosphatidylinositol 3-kinase regulatory subunit alpha-like isoform X1 [KO:K02649]
124038008  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
124009278  phosphatidylinositol 3-kinase regulatory subunit gamma-like [KO:K02649]
124039893  3-phosphoinositide-dependent protein kinase 1-like [KO:K06276] [EC:2.7.11.1]
124048341  pdpk1b; 3-phosphoinositide-dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
123990831  RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
123992566  RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
123995162  RAC-alpha serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
124040281  akt3a; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
124005175  RAC-beta serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
124005558  RAC-beta serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
124006692  RAC-beta serine/threonine-protein kinase-like isoform X1 [KO:K04456] [EC:2.7.11.1]
124001450  RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
124015998  RAC-gamma serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
124046412  RAC-alpha serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
124002457  RAC-gamma serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
124040034  phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
124048158  ptenb; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
124041252  phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN-like isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
124038256  phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN-like isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
124035796  GTPase HRas [KO:K02833]
124002027  GTPase HRas-like [KO:K02833]
124020877  GTPase HRas-like [KO:K07827]
124035184  GTPase KRas isoform X1 [KO:K07827]
124002488  kras; GTPase KRas isoform X1 [KO:K07827]
124048448  ras-related protein M-Ras-like [KO:K07831]
124011373  ras-related protein M-Ras-like [KO:K07831]
124042914  ras-related protein M-Ras-like [KO:K07831]
124007671  ras-related protein M-Ras [KO:K07831]
124045331  ras-related protein M-Ras-like [KO:K07831]
124033630  rras2; ras-related protein R-Ras2 [KO:K07830]
124035611  ras-related protein R-Ras2 [KO:K07830]
124000070  rras; ras-related protein R-Ras [KO:K07830]
124037933  ras-related protein R-Ras-like [KO:K07830]
124045679  RAF proto-oncogene serine/threonine-protein kinase-like [KO:K04366] [EC:2.7.11.1]
124031697  raf1a; raf-1 proto-oncogene, serine/threonine kinase a isoform X1 [KO:K04366] [EC:2.7.11.1]
124037367  map2k1; LOW QUALITY PROTEIN: dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
124037445  LOW QUALITY PROTEIN: dual specificity mitogen-activated protein kinase kinase 1-like [KO:K04368] [EC:2.7.12.2]
123997082  map2k2a; dual specificity mitogen-activated protein kinase kinase 2a [KO:K04369] [EC:2.7.12.2]
124037664  dual specificity mitogen-activated protein kinase kinase 2-like [KO:K04369] [EC:2.7.12.2]
124009586  map2k2b; dual specificity mitogen-activated protein kinase kinase 2b [KO:K04369] [EC:2.7.12.2]
124034739  mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
124036684  mitogen-activated protein kinase 1-like [KO:K04371] [EC:2.7.11.24]
124037950  mitogen-activated protein kinase 1-like [KO:K04371] [EC:2.7.11.24]
124000779  mitogen-activated protein kinase 1-like [KO:K04371] [EC:2.7.11.24]
123992906  hypoxia-inducible factor 1-alpha-like [KO:K08268]
124004697  hypoxia-inducible factor 1-alpha-like isoform X1 [KO:K08268]
124046524  hypoxia-inducible factor 1-alpha-like isoform X1 [KO:K08268]
124002136  hypoxia-inducible factor 1-alpha isoform X1 [KO:K08268]
124041084  DNA damage-inducible transcript 4 protein-like [KO:K08270]
124041085  DNA damage-inducible transcript 4 protein-like [KO:K08270]
124041086  DNA damage-inducible transcript 4 protein-like [KO:K08270]
124041132  DNA damage-inducible transcript 4 protein-like [KO:K08270]
124020654  LOW QUALITY PROTEIN: tuberin-like [KO:K07207]
124020660  LOW QUALITY PROTEIN: tuberin-like [KO:K07207]
124033995  hamartin-like isoform X1 [KO:K07206]
124048898  hamartin-like [KO:K07206]
124006965  LOW QUALITY PROTEIN: hamartin-like [KO:K07206]
124048620  BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like [KO:K15464]
124041240  BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like [KO:K15464]
124000323  BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like [KO:K15464]
123991375  GTP-binding protein Rheb isoform X1 [KO:K07208]
124002993  GTP-binding protein Rheb-like [KO:K07208]
124009872  GTP-binding protein Rheb-like isoform X1 [KO:K07208]
124041040  GTP-binding protein Rheb-like [KO:K07208]
124019803  GTP-binding protein Rheb-like [KO:K07208]
124039615  GTP-binding protein Rheb-like [KO:K07208]
124003457  regulatory-associated protein of mTOR-like isoform X1 [KO:K07204]
124015084  LOW QUALITY PROTEIN: regulatory-associated protein of mTOR-like [KO:K07204]
124020723  DEP domain-containing mTOR-interacting protein-like [KO:K20402]
124020724  DEP domain-containing mTOR-interacting protein-like [KO:K20402]
124020987  DEP domain-containing mTOR-interacting protein-like [KO:K20402]
124031476  si:dkeyp-97e7.9; DEP domain-containing mTOR-interacting protein isoform X1 [KO:K20402]
124031850  mtor; serine/threonine-protein kinase mTOR isoform X1 [KO:K07203] [EC:2.7.11.1]
123998982  uncharacterized protein LOC123998982 isoform X1 [KO:K16184]
124015293  uncharacterized protein LOC124015293 [KO:K16184]
124040174  mlst8; target of rapamycin complex subunit lst8 [KO:K08266]
123992688  ribosomal protein S6 kinase beta-1-like isoform X1 [KO:K04688] [EC:2.7.11.1]
124010554  ribosomal protein S6 kinase beta-1-like [KO:K04688] [EC:2.7.11.1]
124012143  ribosomal protein S6 kinase beta-2-like [KO:K04688] [EC:2.7.11.1]
123999526  ribosomal protein S6 kinase beta-1-like isoform X1 [KO:K04688] [EC:2.7.11.1]
124006198  ribosomal protein S6 kinase beta-1-like [KO:K04688] [EC:2.7.11.1]
124001484  ribosomal protein S6 kinase beta-2-like [KO:K04688] [EC:2.7.11.1]
124000466  igbp1; immunoglobulin-binding protein 1 isoform X1 [KO:K17606]
124008793  immunoglobulin-binding protein 1-like [KO:K17606]
123989480  ppp2cb; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
123993708  serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform-like [KO:K04382] [EC:3.1.3.16]
124010911  serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform-like isoform X1 [KO:K04382] [EC:3.1.3.16]
124033974  serine/threonine-protein phosphatase 2A catalytic subunit beta isoform-like [KO:K04382] [EC:3.1.3.16]
124013707  serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform-like isoform X1 [KO:K04382] [EC:3.1.3.16]
123999690  serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform-like [KO:K04382] [EC:3.1.3.16]
124016626  serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
124049022  serine/threonine-protein kinase ULK1-like isoform X1 [KO:K21357] [EC:2.7.11.1]
124036235  serine/threonine-protein kinase ULK1-like isoform X1 [KO:K21357] [EC:2.7.11.1]
124006762  serine/threonine-protein kinase ULK1-like isoform X1 [KO:K21357] [EC:2.7.11.1]
123992640  serine/threonine-protein kinase ULK2-like isoform X1 [KO:K08269] [EC:2.7.11.1]
124006441  serine/threonine-protein kinase ULK2-like isoform X1 [KO:K08269] [EC:2.7.11.1]
124033915  atg13; autophagy-related protein 13 isoform X1 [KO:K08331]
124035882  autophagy-related protein 13-like isoform X1 [KO:K08331]
124010468  autophagy-related protein 101-like [KO:K19730]
123998667  autophagy-related protein 101 [KO:K19730]
124041749  rb1cc1; RB1-inducible coiled-coil protein 1 isoform X1 [KO:K17589]
124009369  RB1-inducible coiled-coil protein 1-like isoform X1 [KO:K17589]
123993597  atg2a; autophagy-related protein 2 homolog A [KO:K17906]
124010505  autophagy-related protein 2 homolog A-like [KO:K17906]
124046472  autophagy-related protein 2 homolog B-like [KO:K17906]
124040213  WD repeat domain phosphoinositide-interacting protein 1-like isoform X1 [KO:K17908]
124018519  WD repeat domain phosphoinositide-interacting protein 2-like [KO:K17908]
124023896  WD repeat domain phosphoinositide-interacting protein 1-like [KO:K17908]
124023924  WD repeat domain phosphoinositide-interacting protein 1-like [KO:K17908]
124025854  WD repeat domain phosphoinositide-interacting protein 1-like isoform X1 [KO:K17908]
124029846  WD repeat domain phosphoinositide-interacting protein 2 [KO:K17908]
124038574  WD repeat domain phosphoinositide-interacting protein 1-like [KO:K17908]
124040112  wdr45b; WD repeat domain phosphoinositide-interacting protein 3 isoform X1 [KO:K22991]
124048096  WD repeat domain phosphoinositide-interacting protein 3-like isoform X1 [KO:K22991]
124007269  wdr45; WD repeat domain phosphoinositide-interacting protein 4 [KO:K22991]
124010888  autophagy-related protein 9A-like isoform X1 [KO:K17907]
124041743  autophagy-related protein 9A-like [KO:K17907]
124008947  autophagy-related protein 9A-like isoform X1 [KO:K17907]
124009164  autophagy-related protein 9A-like [KO:K17907]
124007478  supt20; LOW QUALITY PROTEIN: transcription factor SPT20 homolog [KO:K21245]
124015478  transcription factor SPT20 homolog isoform X1 [KO:K21245]
124019949  smcr8a; guanine nucleotide exchange protein smcr8a isoform X1 [KO:K23611]
124021631  guanine nucleotide exchange protein smcr8a-like isoform X1 [KO:K23611]
124022095  guanine nucleotide exchange protein smcr8a-like [KO:K23611]
124049085  wdr41; WD repeat-containing protein 41 isoform X1 [KO:K23610]
124046558  guanine nucleotide exchange C9orf72-like isoform X1 [KO:K23609]
123997137  ras-related protein Rab-8A [KO:K07901]
123998909  ras-related protein Rab-8A-like [KO:K07901]
124009546  ras-related protein Rab-8A-like [KO:K07901]
124006060  ras-related protein Rab-39B [KO:K07925]
124006722  ras-related protein Rab-39B-like [KO:K07925]
124014159  ras-related protein Rab-39B-like [KO:K07925]
124007672  ras-related protein Rab-39B-like [KO:K07925]
124012300  ras-related protein Rab-39B-like [KO:K07925]
124042761  ras-related protein Rab-39B-like [KO:K07925]
123993489  sequestosome-1-like [KO:K14381]
124011061  sqstm1; LOW QUALITY PROTEIN: sequestosome-1 [KO:K14381]
124026129  tbk1; serine/threonine-protein kinase TBK1 [KO:K05410] [EC:2.7.11.10]
124042557  LOW QUALITY PROTEIN: TRAF family member-associated NF-kappa-B activator-like [KO:K12650]
124043831  TRAF family member-associated NF-kappa-B activator-like [KO:K12650]
123993000  ras-related protein Rab-1A-like [KO:K07874]
124003888  ras-related protein ORAB-1-like isoform X1 [KO:K07874]
124041326  ras-related protein ORAB-1 [KO:K07874]
124004885  ras-related protein Rab-1A-like [KO:K07874]
124015496  ras-related protein ORAB-1-like [KO:K07874]
124038208  rab1ab; ras-related protein Rab-1A [KO:K07874]
123999276  rraga; ras-related GTP-binding protein A [KO:K16185]
123997606  ras-related GTP-binding protein C [KO:K16186]
124005402  ras-related GTP-binding protein C-like [KO:K16186]
124043299  ras-related GTP-binding protein C-like isoform X1 [KO:K16186]
124002122  rragd; ras-related GTP-binding protein D isoform X1 [KO:K16186]
123997101  serine/threonine-protein kinase STK11-like [KO:K07298] [EC:2.7.11.1]
124009658  serine/threonine-protein kinase STK11-like [KO:K07298] [EC:2.7.11.1]
124041515  serine/threonine-protein kinase STK11-like [KO:K07298] [EC:2.7.11.1]
123996857  5'-AMP-activated protein kinase catalytic subunit alpha-2-like isoform X1 [KO:K07198] [EC:2.7.11.31]
124049141  5'-AMP-activated protein kinase catalytic subunit alpha-1-like [KO:K07198] [EC:2.7.11.31]
124006727  5'-AMP-activated protein kinase catalytic subunit alpha-1-like [KO:K07198] [EC:2.7.11.31]
124037824  prkaa2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 isoform X1 [KO:K07198] [EC:2.7.11.31]
123994965  prkacba; protein kinase, cAMP-dependent, catalytic, beta a isoform X1 [KO:K04345] [EC:2.7.11.11]
124002772  cAMP-dependent protein kinase catalytic subunit alpha-like [KO:K04345] [EC:2.7.11.11]
124003154  cAMP-dependent protein kinase catalytic subunit alpha-like [KO:K04345] [EC:2.7.11.11]
124041764  cAMP-dependent protein kinase catalytic subunit beta-like isoform X1 [KO:K04345] [EC:2.7.11.11]
124027026  cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
124009569  cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
124002983  protein kinase C delta type-like [KO:K06068] [EC:2.7.11.13]
124031271  protein kinase C delta type-like [KO:K06068] [EC:2.7.11.13]
124031434  protein kinase C delta type-like isoform X1 [KO:K06068] [EC:2.7.11.13]
124016910  protein kinase C delta type-like [KO:K06068] [EC:2.7.11.13]
123993247  mitogen-activated protein kinase 9-like isoform X1 [KO:K04440] [EC:2.7.11.24]
124039986  mitogen-activated protein kinase 8-like isoform X1 [KO:K04440] [EC:2.7.11.24]
124048207  mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
124048657  mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
124041473  mitogen-activated protein kinase 8-like isoform X1 [KO:K04440] [EC:2.7.11.24]
123999662  mapk10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
124006790  mitogen-activated protein kinase 9-like [KO:K04440] [EC:2.7.11.24]
124038076  mitogen-activated protein kinase 8-like isoform X1 [KO:K04440] [EC:2.7.11.24]
123991358  apoptosis regulator Bcl-2-like isoform X1 [KO:K02161]
124009817  apoptosis regulator Bcl-2-like [KO:K02161]
124041790  apoptosis regulator Bcl-2-like [KO:K02161]
124039599  apoptosis regulator Bcl-2-like [KO:K02161]
124003275  bcl-2-like protein 1 [KO:K04570]
124031480  bcl-2-like protein 1 isoform X1 [KO:K04570]
124045522  bcl-2-like protein 1 [KO:K04570]
124031923  bcl2l1; bcl-2-like protein 1 [KO:K04570]
123993880  bcl2-associated agonist of cell death-like [KO:K02158]
124007485  bcl2-associated agonist of cell death-like [KO:K02158]
124029329  badb; BCL2 associated agonist of cell death b [KO:K02158]
124048418  becn1; beclin-1 isoform X1 [KO:K08334]
124021600  nuclear receptor-binding factor 2-like [KO:K21246]
124028746  LOW QUALITY PROTEIN: nuclear receptor-binding factor 2-like [KO:K21246]
123998321  pik3r4; phosphoinositide 3-kinase regulatory subunit 4 isoform X1 [KO:K08333] [EC:2.7.11.1]
124014089  pik3c3; phosphatidylinositol 3-kinase catalytic subunit type 3 isoform X1 [KO:K00914] [EC:2.7.1.137]
124001987  atg14; beclin 1-associated autophagy-related key regulator [KO:K17889]
124046652  beclin 1-associated autophagy-related key regulator-like isoform X1 [KO:K17889]
124039975  ambra1b; activating molecule in BECN1-regulated autophagy protein 1B [KO:K17985]
124033924  activating molecule in BECN1-regulated autophagy protein 1A-like isoform X1 [KO:K17985]
124004917  activating molecule in BECN1-regulated autophagy protein 1B-like isoform X1 [KO:K17985]
124035894  activating molecule in BECN1-regulated autophagy protein 1-like isoform X1 [KO:K17985]
124026357  LOW QUALITY PROTEIN: TNF receptor-associated factor 6-like [KO:K03175] [EC:2.3.2.27]
124027860  TNF receptor-associated factor 6-like [KO:K03175] [EC:2.3.2.27]
124033071  TNF receptor-associated factor 6-like [KO:K03175] [EC:2.3.2.27]
124045592  tumor protein p53-inducible nuclear protein 2 isoform X1 [KO:K21247]
124033869  tumor protein p53-inducible nuclear protein 2-like [KO:K21247]
124035845  tumor protein p53-inducible nuclear protein 1-like [KO:K21247]
123992691  vacuole membrane protein 1-like [KO:K21248]
124010561  vacuole membrane protein 1-like isoform X1 [KO:K21248]
124005864  vacuole membrane protein 1-like [KO:K21248]
123998310  syntaxin-17-like [KO:K08491]
124017027  syntaxin-17-like isoform X1 [KO:K08491]
124010405  UV radiation resistance-associated gene protein-like [KO:K21249]
123999603  UV radiation resistance-associated gene protein-like [KO:K21249]
123991203  sh3glb1a; endophilin-B1a isoform X1 [KO:K11248]
123996802  run domain Beclin-1-interacting and cysteine-rich domain-containing protein-like isoform X1 [KO:K19330]
123997459  run domain Beclin-1-interacting and cysteine-rich domain-containing protein-like isoform X1 [KO:K19330]
124049032  calcium/calmodulin-dependent protein kinase kinase 2-like isoform X1 [KO:K07359] [EC:2.7.11.17]
124006669  calcium/calmodulin-dependent protein kinase kinase 2-like [KO:K07359] [EC:2.7.11.17]
123990663  mitogen-activated protein kinase kinase kinase 7-like isoform X1 [KO:K04427] [EC:2.7.11.25]
123994996  mitogen-activated protein kinase kinase kinase 7-like isoform X1 [KO:K04427] [EC:2.7.11.25]
124001457  mitogen-activated protein kinase kinase kinase 7-like isoform X1 [KO:K04427] [EC:2.7.11.25]
124017527  mitogen-activated protein kinase kinase kinase 7-like [KO:K04427] [EC:2.7.11.25]
124024581  serine/threonine-protein kinase/endoribonuclease IRE1-like [KO:K08852] [EC:2.7.11.1 3.1.26.-]
123999474  ern1; serine/threonine-protein kinase/endoribonuclease IRE1 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
124025283  serine/threonine-protein kinase/endoribonuclease IRE1-like isoform X1 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
123999949  serine/threonine-protein kinase/endoribonuclease IRE1-like [KO:K08852] [EC:2.7.11.1 3.1.26.-]
124003822  inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
124003962  inositol 1,4,5-trisphosphate receptor type 1-like isoform X1 [KO:K04958]
124031230  inositol 1,4,5-trisphosphate receptor type 1-like isoform X1 [KO:K04958]
124031497  itpr1b; LOW QUALITY PROTEIN: inositol 1,4,5-trisphosphate receptor type 1 [KO:K04958]
124009688  death-associated protein kinase 3-like [KO:K08803] [EC:2.7.11.1]
124041620  death-associated protein kinase 3-like [KO:K08803] [EC:2.7.11.1]
123997812  death-associated protein kinase 2-like [KO:K08803] [EC:2.7.11.1]
124012746  death-associated protein kinase 2-like [KO:K08803] [EC:2.7.11.1]
124023632  dapk2a; death-associated protein kinase 2a isoform X1 [KO:K08803] [EC:2.7.11.1]
124043420  death-associated protein kinase 2-like [KO:K08803] [EC:2.7.11.1]
124006221  death-associated protein kinase 2-like isoform X1 [KO:K08803] [EC:2.7.11.1]
124036689  dapk1; LOW QUALITY PROTEIN: death-associated protein kinase 1 [KO:K08803] [EC:2.7.11.1]
124036962  dapk2b; death-associated protein kinase 2 [KO:K08803] [EC:2.7.11.1]
123994012  high mobility group protein B1-like [KO:K10802]
123994796  high mobility group-T protein-like [KO:K10802]
124007019  high mobility group-T protein isoform X1 [KO:K10802]
124015289  high mobility group-T protein-like [KO:K10802]
124046837  eif2ak3; eukaryotic translation initiation factor 2-alpha kinase 3 [KO:K08860] [EC:2.7.11.1]
124001294  eIF-2-alpha kinase GCN2-like [KO:K16196] [EC:2.7.11.1]
123990899  eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
124002126  eukaryotic translation initiation factor 2 subunit 1-like isoform X1 [KO:K03237]
124046664  eif2s1a; eukaryotic translation initiation factor 2 subunit 1a [KO:K03237]
123990884  myotubularin-related protein 4-like [KO:K18082] [EC:3.1.3.48 3.1.3.64 3.1.3.95]
124034413  myotubularin-related protein 3-like isoform X1 [KO:K18082] [EC:3.1.3.48 3.1.3.64 3.1.3.95]
124036193  mtmr3; myotubularin-related protein 3 isoform X1 [KO:K18082] [EC:3.1.3.48 3.1.3.64 3.1.3.95]
124000121  mtmr4; myotubularin-related protein 4 isoform X1 [KO:K18082] [EC:3.1.3.48 3.1.3.64 3.1.3.95]
124026852  myotubularin-related protein 14-like isoform X1 [KO:K18086] [EC:3.1.3.64 3.1.3.95]
124002548  mtmr14; myotubularin-related protein 14 isoform X1 [KO:K18086] [EC:3.1.3.64 3.1.3.95]
123990492  zfyve1; zinc finger FYVE domain-containing protein 1 [KO:K17603]
123992922  zinc finger FYVE domain-containing protein 1-like isoform X1 [KO:K17603]
124005675  zinc finger FYVE domain-containing protein 1-like [KO:K17603]
124001771  zinc finger FYVE domain-containing protein 1-like [KO:K17603]
123996913  ubiquitin-like protein ATG12 [KO:K08336]
124005381  ubiquitin-like protein ATG12 [KO:K08336]
123997777  autophagy protein 5-like [KO:K08339]
124005361  autophagy protein 5-like [KO:K08339]
123993167  atg16l1; autophagy-related protein 16-1 isoform X1 [KO:K17890]
124004975  protein Atg16l2-like [KO:K20868]
124025110  atg7; ubiquitin-like modifier-activating enzyme ATG7 [KO:K08337]
124007153  atg10; ubiquitin-like-conjugating enzyme ATG10 isoform X1 [KO:K17888]
124022310  LOW QUALITY PROTEIN: ubiquitin-like-conjugating enzyme ATG3 [KO:K08343]
124022314  LOW QUALITY PROTEIN: ubiquitin-like-conjugating enzyme ATG3 [KO:K08343]
123993394  ras-related protein Rab-33B-like [KO:K07920]
124010453  ras-related protein Rab-33B-like [KO:K07920]
124025024  ras-related protein Rab-33B-like [KO:K07920]
124029629  ras-related protein Rab-33B-like [KO:K07920]
123994564  protein kinase C theta type-like [KO:K18052] [EC:2.7.11.13]
124014309  LOW QUALITY PROTEIN: protein kinase C theta type-like [KO:K18052] [EC:2.7.11.13]
124018499  gamma-aminobutyric acid receptor-associated protein-like 2 [KO:K08341]
124004743  gamma-aminobutyric acid receptor-associated protein-like 1 [KO:K08341]
123998123  gamma-aminobutyric acid receptor-associated protein-like 1 [KO:K08341]
124005478  gamma-aminobutyric acid receptor-associated protein [KO:K08341]
124013543  gamma-aminobutyric acid receptor-associated protein-like [KO:K08341]
123999940  gamma-aminobutyric acid receptor-associated protein-like 2 isoform X1 [KO:K08341]
124007834  gamma-aminobutyric acid receptor-associated protein-like [KO:K08341]
123994155  map1lc3cl; microtubule-associated proteins 1A/1B light chain 3C [KO:K10435]
123999562  microtubule-associated proteins 1A/1B light chain 3B isoform X1 [KO:K10435]
124038100  microtubule-associated proteins 1A/1B light chain 3B-like isoform X1 [KO:K10435]
124008077  map1lc3a; microtubule-associated proteins 1A/1B light chain 3A [KO:K10435]
124016062  microtubule-associated proteins 1A/1B light chain 3C-like [KO:K10435]
124002516  microtubule-associated proteins 1A/1B light chain 3C-like [KO:K10435]
123996518  cysteine protease ATG4B-like isoform X1 [KO:K08342] [EC:3.4.22.-]
123996541  atg4b; cysteine protease ATG4B isoform X1 [KO:K08342] [EC:3.4.22.-]
123996650  atg4c; cysteine protease ATG4C [KO:K08342] [EC:3.4.22.-]
123999059  cysteine protease ATG4D-like [KO:K08342] [EC:3.4.22.-]
124005865  cysteine protease ATG4A-like isoform X1 [KO:K08342] [EC:3.4.22.-]
124006800  cysteine protease ATG4A-like [KO:K08342] [EC:3.4.22.-]
124015693  cysteine protease ATG4D-like [KO:K08342] [EC:3.4.22.-]
124015871  atg4da; cysteine protease ATG4D [KO:K08342] [EC:3.4.22.-]
124039959  next to BRCA1 gene 1 protein-like isoform X1 [KO:K17987]
124048237  next to BRCA1 gene 1 protein-like [KO:K17987]
124000575  next to BRCA1 gene 1 protein-like [KO:K17987]
124016334  next to BRCA1 gene 1 protein-like isoform X1 [KO:K17987]
123994572  optineurin-like isoform X1 [KO:K19946]
124013710  optineurin-like isoform X1 [KO:K19946]
124039868  tax1-binding protein 1 homolog B-like isoform X1 [KO:K21348]
124048272  calcium-binding and coiled-coil domain-containing protein 2-like isoform X1 [KO:K21348]
124019474  tax1bp1b; tax1-binding protein 1 homolog B isoform X1 [KO:K21347]
124012932  LOW QUALITY PROTEIN: tax1-binding protein 1 homolog A-like [KO:K21347]
124036666  wdfy3; LOW QUALITY PROTEIN: WD repeat and FYVE domain-containing protein 3 [KO:K22262]
123997202  ubiquitin-60S ribosomal protein L40-like [KO:K02927]
123998021  ubiquitin-60S ribosomal protein L40 [KO:K02927]
124042004  ubiquitin-60S ribosomal protein L40-like [KO:K02927]
124009543  ubiquitin-60S ribosomal protein L40-like [KO:K02927]
124041176  ubiquitin-40S ribosomal protein S27a [KO:K02977]
124038314  ubiquitin-40S ribosomal protein S27a-like [KO:K02977]
124007424  polyubiquitin-B [KO:K04551]
123998754  ubb; polyubiquitin-B isoform X1 [KO:K08770]
124035958  snap29; synaptosomal-associated protein 29 [KO:K08509]
124034152  vamp8; vesicle-associated membrane protein 8 [KO:K08512]
123999191  vesicle-associated membrane protein 8-like [KO:K08512]
124036496  vesicle-associated membrane protein 8-like isoform X1 [KO:K08512]
124034106  synaptobrevin homolog YKT6-like [KO:K08516]
124049134  synaptobrevin homolog YKT6-like [KO:K08516]
124036536  synaptobrevin homolog YKT6 [KO:K08516]
123990697  syntaxin-7-like [KO:K08488]
123995030  syntaxin-7-like [KO:K08488]
124034240  epg5; ectopic P granules protein 5 homolog [KO:K23883]
124039912  pleckstrin homology domain-containing family M member 1-like [KO:K23282]
124048307  pleckstrin homology domain-containing family M member 1-like [KO:K23282]
124000500  vps11; vacuolar protein sorting-associated protein 11 homolog [KO:K20179]
124021858  vps16; vacuolar protein sorting-associated protein 16 homolog [KO:K20180]
123990491  vacuolar protein sorting-associated protein 18 homolog [KO:K20181]
124033303  vps33a; vacuolar protein sorting-associated protein 33A [KO:K20182]
124036319  vacuolar protein sorting-associated protein 33A-like isoform X1 [KO:K20182]
124001992  vam6/Vps39-like protein [KO:K20183]
124046821  vam6/Vps39-like protein isoform X1 [KO:K20183]
123991072  vacuolar protein sorting-associated protein 41 homolog [KO:K20184]
124039771  vacuolar protein sorting-associated protein 41 homolog [KO:K20184]
124041292  baculoviral IAP repeat-containing protein 6-like isoform X1 [KO:K10586] [EC:2.3.2.23]
124038225  LOW QUALITY PROTEIN: baculoviral IAP repeat-containing protein 6-like [KO:K10586] [EC:2.3.2.23]
124041543  Golgi reassembly-stacking protein 2-like [KO:K26797]
124043037  Golgi reassembly-stacking protein 2-like [KO:K26797]
124042891  Golgi reassembly-stacking protein 2-like [KO:K26797]
124009766  gorasp1a; Golgi reassembly-stacking protein 1a [KO:K26797]
124010096  gorasp2; Golgi reassembly-stacking protein 2 isoform X1 [KO:K26797]
124002624  ras-related protein rab7-like [KO:K07897]
124003316  ras-related protein rab7 [KO:K07897]
124049110  ras-related protein rab7-like [KO:K07897]
124036286  ras-related protein Rab-7a-like isoform X1 [KO:K07897]
124007002  zgc:100918; ras-related protein rab7-like [KO:K07897]
124031264  ras-related protein rab7-like [KO:K07897]
124031444  ras-related protein rab7-like [KO:K07897]
123993538  lysosome-associated membrane glycoprotein 2-like isoform X1 [KO:K06528]
124010489  lamp2; lysosome-associated membrane glycoprotein 2 isoform X1 [KO:K06528]
124024839  LOW QUALITY PROTEIN: lysosome-associated membrane glycoprotein 1-like [KO:K06528]
124026379  lysosome-associated membrane glycoprotein 1-like [KO:K06528]
124027392  lysosome-associated membrane glycoprotein 1-like [KO:K06528]
124044211  lysosome-associated membrane glycoprotein 1-like [KO:K06528]
124044284  lysosome-associated membrane glycoprotein 1-like [KO:K06528]
124019850  cathepsin D-like isoform X1 [KO:K01379] [EC:3.4.23.5]
124019880  cathepsin D-like isoform X1 [KO:K01379] [EC:3.4.23.5]
123998568  cathepsin D-like isoform X1 [KO:K01379] [EC:3.4.23.5]
124024511  cathepsin D-like isoform X1 [KO:K01379] [EC:3.4.23.5]
124015511  napsa; LOW QUALITY PROTEIN: napsin-A [KO:K01379] [EC:3.4.23.5]
124047777  procathepsin L-like [KO:K01365] [EC:3.4.22.15]
124047778  procathepsin L-like [KO:K01365] [EC:3.4.22.15]
124047780  procathepsin L-like [KO:K01365] [EC:3.4.22.15]
124047781  procathepsin L-like [KO:K01365] [EC:3.4.22.15]
124048614  procathepsin L-like [KO:K01365] [EC:3.4.22.15]
124048615  procathepsin L-like [KO:K01365] [EC:3.4.22.15]
123999588  LOW QUALITY PROTEIN: procathepsin L-like [KO:K01365] [EC:3.4.22.15]
124037743  cts12; procathepsin L [KO:K01365] [EC:3.4.22.15]
124001749  ctsl.1; cathepsin L.1 [KO:K01365] [EC:3.4.22.15]
124004113  procathepsin L-like [KO:K01365] [EC:3.4.22.15]
123995189  ctsbb; cathepsin Bb [KO:K01363] [EC:3.4.22.1]
124001459  cathepsin B-like [KO:K01363] [EC:3.4.22.1]
124046724  ctsba; cathepsin B [KO:K01363] [EC:3.4.22.1]
Compound
C00035  GDP
C00044  GTP
C00350  Phosphatidylethanolamine
C01194  1-Phosphatidyl-D-myo-inositol
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:15325584
  Authors
Meijer AJ, Codogno P.
  Title
Regulation and role of autophagy in mammalian cells.
  Journal
Int J Biochem Cell Biol 36:2445-62 (2004)
DOI:10.1016/j.biocel.2004.02.002
Reference
PMID:16099218
  Authors
Deretic V.
  Title
Autophagy in innate and adaptive immunity.
  Journal
Trends Immunol 26:523-8 (2005)
DOI:10.1016/j.it.2005.08.003
Reference
PMID:16200202
  Authors
Levine B, Yuan J.
  Title
Autophagy in cell death: an innocent convict?
  Journal
J Clin Invest 115:2679-88 (2005)
DOI:10.1172/JCI26390
Reference
PMID:15325588
  Authors
Tanida I, Ueno T, Kominami E.
  Title
LC3 conjugation system in mammalian autophagy.
  Journal
Int J Biochem Cell Biol 36:2503-18 (2004)
DOI:10.1016/j.biocel.2004.05.009
Reference
PMID:15928708
  Authors
Lum JJ, DeBerardinis RJ, Thompson CB.
  Title
Autophagy in metazoans: cell survival in the land of plenty.
  Journal
Nat Rev Mol Cell Biol 6:439-48 (2005)
DOI:10.1038/nrm1660
Reference
PMID:15978794
  Authors
Reggiori F, Klionsky DJ.
  Title
Autophagosomes: biogenesis from scratch?
  Journal
Curr Opin Cell Biol 17:415-22 (2005)
DOI:10.1016/j.ceb.2005.06.007
Reference
PMID:11099404
  Authors
Klionsky DJ, Emr SD.
  Title
Autophagy as a regulated pathway of cellular degradation.
  Journal
Science 290:1717-21 (2000)
DOI:10.1126/science.290.5497.1717
Reference
PMID:16125113
  Authors
Bechet D, Tassa A, Taillandier D, Combaret L, Attaix D.
  Title
Lysosomal proteolysis in skeletal muscle.
  Journal
Int J Biochem Cell Biol 37:2098-114 (2005)
DOI:10.1016/j.biocel.2005.02.029
Reference
PMID:19653858
  Authors
He C, Klionsky DJ
  Title
Regulation mechanisms and signaling pathways of autophagy.
  Journal
Annu Rev Genet 43:67-93 (2009)
DOI:10.1146/annurev-genet-102808-114910
Reference
PMID:19802558
  Authors
Yang Z, Klionsky DJ
  Title
An overview of the molecular mechanism of autophagy.
  Journal
Curr Top Microbiol Immunol 335:1-32 (2009)
DOI:10.1007/978-3-642-00302-8_1
Reference
PMID:20034776
  Authors
Yang Z, Klionsky DJ
  Title
Mammalian autophagy: core molecular machinery and signaling regulation.
  Journal
Curr Opin Cell Biol 22:124-31 (2010)
DOI:10.1016/j.ceb.2009.11.014
Reference
PMID:21187343
  Authors
Chen Y, Klionsky DJ
  Title
The regulation of autophagy - unanswered questions.
  Journal
J Cell Sci 124:161-70 (2011)
DOI:10.1242/jcs.064576
Reference
PMID:21801009
  Authors
Mizushima N, Yoshimori T, Ohsumi Y
  Title
The role of Atg proteins in autophagosome formation.
  Journal
Annu Rev Cell Dev Biol 27:107-32 (2011)
DOI:10.1146/annurev-cellbio-092910-154005
Reference
PMID:24343578
  Authors
Russell RC, Yuan HX, Guan KL
  Title
Autophagy regulation by nutrient signaling.
  Journal
Cell Res 24:42-57 (2014)
DOI:10.1038/cr.2013.166
Reference
PMID:25948417
  Authors
Noda NN, Fujioka Y
  Title
Atg1 family kinases in autophagy initiation.
  Journal
Cell Mol Life Sci 72:3083-96 (2015)
DOI:10.1007/s00018-015-1917-z
Related
pathway
ogo04010  MAPK signaling pathway
ogo04141  Protein processing in endoplasmic reticulum
ogo04142  Lysosome
ogo04150  mTOR signaling pathway
ogo04910  Insulin signaling pathway
KO pathway
ko04140   
LinkDB

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