KEGG   PATHWAY: ppam05205
Entry
ppam05205                   Pathway                                
Name
Proteoglycans in cancer - Pteronotus mesoamericanus (Parnell's mustached bat)
Description
Many proteoglycans (PGs) in the tumor microenvironment have been shown to be key macromolecules that contribute to biology of various types of cancer including proliferation, adhesion, angiogenesis and metastasis, affecting tumor progress. The four main types of proteoglycans include hyaluronan (HA), which does not occur as a PG but in free form, heparan sulfate proteoglycans (HSPGs), chondroitin sulfate proteoglycans (CSPGs), dematan sulfate proteoglycans (DSPG) and keratan sulfate proteoglycans (KSPGs) [BR:00535]. Among these proteoglycans such as HA, acting with CD44, promotes tumor cell growth and migration, whereas other proteoglycans such as syndecans (-1~-4), glypican (-1, -3) and perlecan may interact with growth factors, cytokines, morphogens and enzymes through HS chains [BR:00536], also leading to tumor growth and invasion. In contrast, some of the small leucine-rich proteolgycans, such as decorin and lumican, can function as tumor repressors, and modulate the signaling pathways by the interaction of their core proteins and multiple receptors.
Class
Human Diseases; Cancer: overview
Pathway map
ppam05205  Proteoglycans in cancer
ppam05205

Organism
Pteronotus mesoamericanus (Parnell's mustached bat) [GN:ppam]
Gene
129080465  CD44; CD44 antigen isoform X1 [KO:K06256]
129070719  SRC; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
129068519  CTTN; src substrate cortactin [KO:K06106]
129071845  HCLS1; hematopoietic lineage cell-specific protein [KO:K06106]
129087036  ERBB2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
129086587  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
129063824  VAV3; guanine nucleotide exchange factor VAV3 [KO:K05730]
129079163  VAV2; guanine nucleotide exchange factor VAV2 isoform X1 [KO:K05730]
129061383  VAV1; proto-oncogene vav isoform X1 [KO:K05730]
129073113  HRAS; GTPase HRas isoform X1 [KO:K02833]
129084969  KRAS; GTPase KRas isoform X1 [KO:K07827]
129063946  NRAS; GTPase NRas [KO:K07828]
129082806  RRAS; ras-related protein R-Ras [KO:K07829]
129080543  RRAS2; ras-related protein R-Ras2 [KO:K07830]
129088421  MRAS; ras-related protein M-Ras [KO:K07831]
129062984  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
129088423  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
129065223  ARAF; serine/threonine-protein kinase A-Raf isoform X1 [KO:K08845] [EC:2.7.11.1]
129064157  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
129078155  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
129078069  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
129086248  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
129078413  ras-related C3 botulinum toxin substrate 1-like [KO:K04392]
129068140  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
129083457  IQGAP1; ras GTPase-activating-like protein IQGAP1 [KO:K16848]
129069153  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
129065226  ELK1; ETS domain-containing protein Elk-1 [KO:K04375]
129067858  ESR1; estrogen receptor isoform X1 [KO:K08550]
129068523  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
129069129  ACTB; actin, cytoplasmic 1 [KO:K05692]
129086550  ACTG1; actin, cytoplasmic 2 [KO:K05692]
129074368  FLNA; filamin-A isoform X1 [KO:K04437]
129072772  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
129074137  TIAM1; rho guanine nucleotide exchange factor TIAM1 [KO:K05731]
129075423  ARHGEF1; rho guanine nucleotide exchange factor 1 isoform X1 [KO:K12330]
129085967  LOW QUALITY PROTEIN: transforming protein RhoA-like [KO:K04513]
129087688  RHOA; transforming protein RhoA [KO:K04513]
129074464  transforming protein RhoA-like isoform X1 [KO:K04513]
129078629  ROCK1; rho-associated protein kinase 1 isoform X1 [KO:K04514] [EC:2.7.11.1]
129067577  ROCK2; rho-associated protein kinase 2 isoform X1 [KO:K17388] [EC:2.7.11.1]
129064794  ANK1; ankyrin-1 isoform X1 [KO:K10380]
129062667  ANK2; ankyrin-2 isoform X1 [KO:K09255]
129069963  ANK3; ankyrin-3 isoform X1 [KO:K09259]
129062066  GAB1; GRB2-associated-binding protein 1 isoform X1 [KO:K09593]
129075675  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
129076577  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
129088291  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
129074969  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
129069407  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
129074590  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
129076641  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
129066231  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
129073033  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
129069216  SLC9A1; sodium/hydrogen exchanger 1 [KO:K05742]
129068538  PPP1CA; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
129066652  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
129087372  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
129075912  PPP1R12A; protein phosphatase 1 regulatory subunit 12A isoform X1 [KO:K06270]
129072927  PPP1R12B; protein phosphatase 1 regulatory subunit 12B isoform X1 [KO:K12329]
129082609  PPP1R12C; protein phosphatase 1 regulatory subunit 12C isoform X1 [KO:K17457]
129085990  ARHGEF12; rho guanine nucleotide exchange factor 12 isoform X1 [KO:K07532]
129070029  PLCE1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 [KO:K05860] [EC:3.1.4.11]
129087685  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
129084965  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
129067386  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
129062638  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X1 [KO:K04515] [EC:2.7.11.17]
129068934  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
129069869  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
129066548  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
129084764  NANOG; homeobox protein NANOG [KO:K10164]
129067099  homeobox protein NANOG-like [KO:K10164]
129070214  DDX5; probable ATP-dependent RNA helicase DDX5 [KO:K12823] [EC:5.6.2.7]
129078969  DROSHA; ribonuclease 3 [KO:K03685] [EC:3.1.26.3]
129086937  STAT3; signal transducer and activator of transcription 3 isoform X1 [KO:K04692]
129063547  TWIST1; twist-related protein 1 [KO:K09069]
129068225  TWIST2; twist-related protein 2 [KO:K09069]
129061633  HOXD10; homeobox protein Hox-D10 [KO:K09295]
129075943  DCN; decorin [KO:K04660]
129071377  IGF1; insulin-like growth factor I isoform X1 [KO:K05459]
129061268  IGF1R; insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
129075656  MTOR; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
129083615  PDPK1; 3-phosphoinositide-dependent protein kinase 1 isoform X1 [KO:K06276] [EC:2.7.11.1]
129068535  RPS6KB2; ribosomal protein S6 kinase beta-2 isoform X1 [KO:K04688] [EC:2.7.11.1]
129071563  RPS6KB1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
129076231  LOW QUALITY PROTEIN: eukaryotic translation initiation factor 4B-like [KO:K03258]
129084823  EIF4B; eukaryotic translation initiation factor 4B isoform X1 [KO:K03258]
129078347  RPS6; 40S ribosomal protein S6 [KO:K02991]
129068919  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
129063310  CAV1; caveolin-1 isoform X1 [KO:K06278]
129062965  CAV2; caveolin-2 [KO:K12958]
129088407  CAV3; caveolin-3 [KO:K12959]
129084788  CD63; CD63 antigen [KO:K06497]
129067419  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
129064891  CASP3; caspase-3 isoform X1 [KO:K02187] [EC:3.4.22.56]
129076675  TGFB1; transforming growth factor beta-1 proprotein [KO:K13375]
129061625  TLR2; toll-like receptor 2 [KO:K10159]
129079317  TLR4; toll-like receptor 4 [KO:K10160]
129077175  PDCD4; programmed cell death protein 4 [KO:K16865]
129066972  TNF; tumor necrosis factor [KO:K03156]
129066360  IL12B; interleukin-12 subunit beta [KO:K05425]
129075763  ERBB3; receptor tyrosine-protein kinase erbB-3 isoform X1 [KO:K05084] [EC:2.7.10.1]
129080370  ERBB4; receptor tyrosine-protein kinase erbB-4 [KO:K05085] [EC:2.7.10.1]
129084081  MYC; myc proto-oncogene protein [KO:K04377]
129088214  CTNNB1; catenin beta-1 isoform X1 [KO:K02105]
129065977  HIF1A; hypoxia-inducible factor 1-alpha [KO:K08268]
129083645  TFAP4; transcription factor AP-4 isoform X1 [KO:K09108]
129067485  VEGFA; vascular endothelial growth factor A [KO:K05448]
129077642  KDR; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
129063382  MET; hepatocyte growth factor receptor isoform X1 [KO:K05099] [EC:2.7.10.1]
129085961  CBL; E3 ubiquitin-protein ligase CBL [KO:K04707] [EC:2.3.2.27]
129071344  TIMP3; metalloproteinase inhibitor 3 [KO:K16866]
129064365  THBS1; thrombospondin-1 [KO:K16857]
129068219  MMP2; 72 kDa type IV collagenase [KO:K01398] [EC:3.4.24.24]
129070437  MMP9; matrix metalloproteinase-9 [KO:K01403] [EC:3.4.24.35]
129075942  LUM; lumican [KO:K08122]
129081899  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
129069755  FAS; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
129075868  MDM2; E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:2.3.2.27]
129072290  TP53; cellular tumor antigen p53 [KO:K04451]
129072973  TGFB2; transforming growth factor beta-2 proprotein isoform X1 [KO:K13376]
129078704  SMAD2; mothers against decapentaplegic homolog 2 [KO:K04500]
129085206  HPSE; heparanase [KO:K07964] [EC:3.2.1.166]
129077096  HPSE2; inactive heparanase-2 isoform X1 [KO:K07965] [EC:3.2.1.-]
129067432  SDC1; syndecan-1 [KO:K06257]
129069768  PLAU; urokinase-type plasminogen activator [KO:K01348] [EC:3.4.21.73]
129082835  PLAUR; urokinase plasminogen activator surface receptor [KO:K03985]
129062886  COL1A2; collagen alpha-2(I) chain [KO:K06236]
129080225  COL1A1; collagen alpha-1(I) chain [KO:K06236]
129071985  ITGA2; integrin alpha-2 [KO:K06481]
129077762  ITGB1; integrin beta-1 isoform X1 [KO:K05719]
129070293  VTN; vitronectin [KO:K06251]
129061828  ITGAV; integrin alpha-V isoform X1 [KO:K06487]
129071582  ITGB3; integrin beta-3 isoform X1 [KO:K06493]
129080366  FN1; fibronectin isoform X1 [KO:K05717]
129071820  ITGB5; integrin beta-5 isoform X1 [KO:K06588]
129063396  HGF; hepatocyte growth factor [KO:K05460]
129084670  WNT1; proto-oncogene Wnt-1 [KO:K03209]
129063044  FZD1; frizzled-1 [KO:K02432]
129080422  FZD7; frizzled-7 [KO:K02432]
129086682  FZD2; frizzled-2 [KO:K02235]
129072540  FZD3; frizzled-3 [KO:K02329]
129072819  FZD4; frizzled-4 [KO:K02354]
129086008  FZD8; frizzled-8 [KO:K02375]
129080389  FZD5; frizzled-5 [KO:K02375]
129084260  FZD6; frizzled-6 isoform X1 [KO:K02376]
129083423  FZD9; frizzled-9 [KO:K02842]
129087122  FZD10; frizzled-10 [KO:K02842]
129084791  ITGA5; integrin alpha-5 [KO:K06484]
129084226  SDC2; syndecan-2 [KO:K16336]
129085572  syndecan-2-like [KO:K16336]
129067883  EZR; ezrin [KO:K08007]
129085899  RDX; radixin [KO:K05762]
129071118  MSN; moesin [KO:K05763]
129070670  SDC4; syndecan-4 [KO:K16338]
129061435  FGF2; LOW QUALITY PROTEIN: fibroblast growth factor 2 [KO:K18497]
129064807  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
129075876  FRS2; fibroblast growth factor receptor substrate 2 [KO:K12461]
129087362  PTPN11; tyrosine-protein phosphatase non-receptor type 11 isoform X1 [KO:K07293] [EC:3.1.3.48]
129064134  son of sevenless homolog 2 isoform X1 [KO:K03099]
129066034  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
129070698  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 [KO:K01116] [EC:3.1.4.11]
129075160  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
129070225  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
129076731  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
129081586  PRKCG; protein kinase C gamma type isoform X1 [KO:K19663] [EC:2.7.11.13]
129083386  NUDT16L1; tudor-interacting repair regulator protein [KO:K16867]
129087393  PXN; paxillin isoform X1 [KO:K05760]
129084348  PTK2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
129066419  HBEGF; proheparin-binding EGF-like growth factor [KO:K08523]
129068253  GPC1; glypican-1 [KO:K08107]
129068503  IGF2; insulin-like growth factor II isoform X1 [KO:K13769]
129073377  GPC3; glypican-3 [KO:K08109]
129063195  WNT2; protein Wnt-2 [KO:K00182]
129063930  WNT2B; protein Wnt-2b [KO:K00182]
129071521  WNT3; proto-oncogene Wnt-3 [KO:K00312]
129079093  WNT3A; protein Wnt-3a [KO:K00312]
129068971  WNT4; protein Wnt-4 [KO:K00408]
129088518  WNT5A; protein Wnt-5a [KO:K00444]
129073424  WNT5B; protein Wnt-5b [KO:K00444]
129080635  WNT6; protein Wnt-6 [KO:K00445]
129077914  WNT7B; protein Wnt-7b [KO:K00572]
129071686  WNT7A; protein Wnt-7a [KO:K00572]
129077118  WNT8B; protein Wnt-8b [KO:K00714]
129066317  WNT8A; protein Wnt-8a [KO:K00714]
129071596  WNT9B; protein Wnt-9b [KO:K01064]
129079070  WNT9A; protein Wnt-9a isoform X1 [KO:K01064]
129084671  WNT10B; protein Wnt-10b [KO:K01357]
129080634  WNT10A; protein Wnt-10a [KO:K01357]
129072640  WNT11; protein Wnt-11 [KO:K01384]
129062854  WNT16; protein Wnt-16 [KO:K01558]
129071477  SHH; sonic hedgehog protein isoform X1 [KO:K11988]
129080628  IHH; indian hedgehog protein [KO:K11989]
129082371  PTCH1; protein patched homolog 1 isoform X1 [KO:K06225]
129063413  SMO; smoothened homolog [KO:K06226]
129069152  HSPG2; basement membrane-specific heparan sulfate proteoglycan core protein [KO:K06255]
129082206  LOW QUALITY PROTEIN: procathepsin L-like [KO:K01365] [EC:3.4.22.15]
129082301  procathepsin L-like isoform X1 [KO:K01365] [EC:3.4.22.15]
129082379  procathepsin L [KO:K01365] [EC:3.4.22.15]
129076820  LOW QUALITY PROTEIN: procathepsin L-like [KO:K01365] [EC:3.4.22.15]
129078478  CTSL; LOW QUALITY PROTEIN: procathepsin L [KO:K01365] [EC:3.4.22.15]
129061554  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
129065641  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
129068299  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
129068300  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
129067412  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
129067413  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
129086048  HSPB2; heat shock protein beta-2 [KO:K09543]
129085050  PTPN6; tyrosine-protein phosphatase non-receptor type 6 isoform X1 [KO:K05697] [EC:3.1.3.48]
Compound
C00426  Dermatan sulfate
C00573  Keratan sulfate
C00607  Chondroitin sulfate
C00925  Heparan sulfate
G10505  Hyaluronic acid
G13063  Binding domain for FGF2 in heparin/heparan sulfate
G13064  Binding domain for HGF in heparin/heparan sulfate
Reference
PMID:18450475
  Authors
Bourguignon LY
  Title
Hyaluronan-mediated CD44 activation of RhoGTPase signaling and cytoskeleton function promotes tumor progression.
  Journal
Semin Cancer Biol 18:251-9 (2008)
DOI:10.1016/j.semcancer.2008.03.007
Reference
PMID:12729888
  Authors
Briggs MW, Sacks DB
  Title
IQGAP1 as signal integrator: Ca2+, calmodulin, Cdc42 and the cytoskeleton.
  Journal
FEBS Lett 542:7-11 (2003)
DOI:10.1016/S0014-5793(03)00333-8
Reference
PMID:12748184
  Authors
Bourguignon LY, Singleton PA, Zhu H, Diedrich F
  Title
Hyaluronan-mediated CD44 interaction with RhoGEF and Rho kinase promotes Grb2-associated binder-1 phosphorylation and phosphatidylinositol 3-kinase signaling leading to cytokine (macrophage-colony stimulating factor) production and breast tumor progression.
  Journal
J Biol Chem 278:29420-34 (2003)
DOI:10.1074/jbc.M301885200
Reference
PMID:15655247
  Authors
Bourguignon LY, Gilad E, Rothman K, Peyrollier K
  Title
Hyaluronan-CD44 interaction with IQGAP1 promotes Cdc42 and ERK signaling, leading to actin binding, Elk-1/estrogen receptor transcriptional activation, and ovarian cancer progression.
  Journal
J Biol Chem 280:11961-72 (2005)
DOI:10.1074/jbc.M411985200
Reference
PMID:11717317
  Authors
Turley EA, Noble PW, Bourguignon LY
  Title
Signaling properties of hyaluronan receptors.
  Journal
J Biol Chem 277:4589-92 (2002)
DOI:10.1074/jbc.R100038200
Reference
PMID:9346940
  Authors
Bourguignon LY, Zhu H, Chu A, Iida N, Zhang L, Hung MC
  Title
Interaction between the adhesion receptor, CD44, and the oncogene product, p185HER2, promotes human ovarian tumor cell activation.
  Journal
J Biol Chem 272:27913-8 (1997)
DOI:10.1074/jbc.272.44.27913
Reference
PMID:22735579
  Authors
Neill T, Schaefer L, Iozzo RV
  Title
Decorin: a guardian from the matrix.
  Journal
Am J Pathol 181:380-7 (2012)
DOI:10.1016/j.ajpath.2012.04.029
Reference
PMID:22194599
  Authors
Neill T, Painter H, Buraschi S, Owens RT, Lisanti MP, Schaefer L, Iozzo RV
  Title
Decorin antagonizes the angiogenic network: concurrent inhibition of Met, hypoxia inducible factor 1alpha, vascular endothelial growth factor A, and induction of thrombospondin-1 and TIMP3.
  Journal
J Biol Chem 287:5492-506 (2012)
DOI:10.1074/jbc.M111.283499
Reference
PMID:19433454
  Authors
Goldoni S, Humphries A, Nystrom A, Sattar S, Owens RT, McQuillan DJ, Ireton K, Iozzo RV
  Title
Decorin is a novel antagonistic ligand of the Met receptor.
  Journal
J Cell Biol 185:743-54 (2009)
DOI:10.1083/jcb.200901129
Reference
PMID:15994311
  Authors
Zhu JX, Goldoni S, Bix G, Owens RT, McQuillan DJ, Reed CC, Iozzo RV
  Title
Decorin evokes protracted internalization and degradation of the epidermal growth factor receptor via caveolar endocytosis.
  Journal
J Biol Chem 280:32468-79 (2005)
DOI:10.1074/jbc.M503833200
Reference
PMID:20974860
  Authors
Buraschi S, Pal N, Tyler-Rubinstein N, Owens RT, Neill T, Iozzo RV
  Title
Decorin antagonizes Met receptor activity and down-regulates {beta}-catenin and Myc levels.
  Journal
J Biol Chem 285:42075-85 (2010)
DOI:10.1074/jbc.M110.172841
Reference
PMID:18798267
  Authors
Goldoni S, Iozzo RV
  Title
Tumor microenvironment: Modulation by decorin and related molecules harboring leucine-rich tandem motifs.
  Journal
Int J Cancer 123:2473-9 (2008)
DOI:10.1002/ijc.23930
Reference
PMID:23058688
  Authors
Sofeu Feugaing DD, Gotte M, Viola M
  Title
More than matrix: the multifaceted role of decorin in cancer.
  Journal
Eur J Cell Biol 92:1-11 (2013)
DOI:10.1016/j.ejcb.2012.08.004
Reference
PMID:22087031
  Authors
Merline R, Moreth K, Beckmann J, Nastase MV, Zeng-Brouwers J, Tralhao JG, Lemarchand P, Pfeilschifter J, Schaefer RM, Iozzo RV, Schaefer L
  Title
Signaling by the matrix proteoglycan decorin controls inflammation and cancer through PDCD4 and MicroRNA-21.
  Journal
Sci Signal 4:ra75 (2011)
DOI:10.1126/scisignal.2001868
Reference
PMID:22033227
  Authors
Teng YH, Aquino RS, Park PW
  Title
Molecular functions of syndecan-1 in disease.
  Journal
Matrix Biol 31:3-16 (2012)
DOI:10.1016/j.matbio.2011.10.001
Reference
PMID:11830493
  Authors
Derksen PW, Keehnen RM, Evers LM, van Oers MH, Spaargaren M, Pals ST
  Title
Cell surface proteoglycan syndecan-1 mediates hepatocyte growth factor binding and promotes Met signaling in multiple myeloma.
  Journal
Blood 99:1405-10 (2002)
DOI:10.1182/blood.V99.4.1405
Reference
PMID:19733083
  Authors
Fux L, Ilan N, Sanderson RD, Vlodavsky I
  Title
Heparanase: busy at the cell surface.
  Journal
Trends Biochem Sci 34:511-9 (2009)
DOI:10.1016/j.tibs.2009.06.005
Reference
PMID:18812315
  Authors
Purushothaman A, Chen L, Yang Y, Sanderson RD
  Title
Heparanase stimulation of protease expression implicates it as a master regulator of the aggressive tumor phenotype in myeloma.
  Journal
J Biol Chem 283:32628-36 (2008)
DOI:10.1074/jbc.M806266200
Reference
PMID:19255147
  Authors
Beauvais DM, Ell BJ, McWhorter AR, Rapraeger AC
  Title
Syndecan-1 regulates alphavbeta3 and alphavbeta5 integrin activation during angiogenesis and is blocked by synstatin, a novel peptide inhibitor.
  Journal
J Exp Med 206:691-705 (2009)
DOI:10.1084/jem.20081278
Reference
PMID:20655987
  Authors
Mahtouk K, Tjin EP, Spaargaren M, Pals ST
  Title
The HGF/MET pathway as target for the treatment of multiple myeloma and B-cell lymphomas.
  Journal
Biochim Biophys Acta 1806:208-19 (2010)
DOI:10.1016/j.bbcan.2010.07.006
Reference
PMID:11931647
  Authors
Munesue S, Kusano Y, Oguri K, Itano N, Yoshitomi Y, Nakanishi H, Yamashina I, Okayama M
  Title
The role of syndecan-2 in regulation of actin-cytoskeletal organization of Lewis lung carcinoma-derived metastatic clones.
  Journal
Biochem J 363:201-9 (2002)
DOI:10.1042/bj3630201
Reference
PMID:10687947
  Authors
Nugent MA, Iozzo RV
  Title
Fibroblast growth factor-2.
  Journal
Int J Biochem Cell Biol 32:115-20 (2000)
DOI:10.1016/S1357-2725(99)00123-5
Reference
PMID:10633082
  Authors
Baciu PC, Saoncella S, Lee SH, Denhez F, Leuthardt D, Goetinck PF
  Title
Syndesmos, a protein that interacts with the cytoplasmic domain of syndecan-4, mediates cell spreading and actin cytoskeletal organization.
  Journal
J Cell Sci 113 Pt 2:315-24 (2000)
Reference
PMID:12509413
  Authors
Thodeti CK, Albrechtsen R, Grauslund M, Asmar M, Larsson C, Takada Y, Mercurio AM, Couchman JR, Wewer UM
  Title
ADAM12/syndecan-4 signaling promotes beta 1 integrin-dependent cell spreading through protein kinase Calpha and RhoA.
  Journal
J Biol Chem 278:9576-84 (2003)
DOI:10.1074/jbc.M208937200
Reference
PMID:14711376
  Authors
Beauvais DM, Rapraeger AC
  Title
Syndecans in tumor cell adhesion and signaling.
  Journal
Reprod Biol Endocrinol 2:3 (2004)
DOI:10.1186/1477-7827-2-3
Reference
PMID:17971838
  Authors
Morgan MR, Humphries MJ, Bass MD
  Title
Synergistic control of cell adhesion by integrins and syndecans.
  Journal
Nat Rev Mol Cell Biol 8:957-69 (2007)
DOI:10.1038/nrm2289
Reference
PMID:18505598
  Authors
Filmus J, Capurro M, Rast J
  Title
Glypicans.
  Journal
Genome Biol 9:224 (2008)
DOI:10.1186/gb-2008-9-5-224
Reference
PMID:23305321
  Authors
Filmus J, Capurro M
  Title
Glypican-3: a marker and a therapeutic target in hepatocellular carcinoma.
  Journal
FEBS J 280:2471-6 (2013)
DOI:10.1111/febs.12126
Reference
PMID:22563565
  Authors
Gao W, Ho M
  Title
The role of glypican-3 in regulating Wnt in hepatocellular carcinomas.
  Journal
Cancer Rep 1:14-19 (2011)
Reference
PMID:24412155
  Authors
Filmus J, Capurro M
  Title
The role of glypicans in Hedgehog signaling.
  Journal
Matrix Biol 35:248-52 (2014)
DOI:10.1016/j.matbio.2013.12.007
Reference
PMID:18413366
  Authors
Cheng W, Tseng CJ, Lin TT, Cheng I, Pan HW, Hsu HC, Lee YM
  Title
Glypican-3-mediated oncogenesis involves the Insulin-like growth factor-signaling pathway.
  Journal
Carcinogenesis 29:1319-26 (2008)
DOI:10.1093/carcin/bgn091
Reference
PMID:21155971
  Authors
Iozzo RV, Sanderson RD
  Title
Proteoglycans in cancer biology, tumour microenvironment and angiogenesis.
  Journal
J Cell Mol Med 15:1013-31 (2011)
DOI:10.1111/j.1582-4934.2010.01236.x
Reference
PMID:18949819
  Authors
Nikitovic D, Katonis P, Tsatsakis A, Karamanos NK, Tzanakakis GN
  Title
Lumican, a small leucine-rich proteoglycan.
  Journal
IUBMB Life 60:818-23 (2008)
DOI:10.1002/iub.131
Related
pathway
ppam04010  MAPK signaling pathway
ppam04020  Calcium signaling pathway
ppam04066  HIF-1 signaling pathway
ppam04150  mTOR signaling pathway
ppam04151  PI3K-Akt signaling pathway
ppam04210  Apoptosis
ppam04310  Wnt signaling pathway
ppam04340  Hedgehog signaling pathway
ppam04350  TGF-beta signaling pathway
ppam04370  VEGF signaling pathway
ppam04510  Focal adhesion
ppam04520  Adherens junction
ppam04810  Regulation of actin cytoskeleton
KO pathway
ko05205   
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