KEGG   PATHWAY: ppam04151
Entry
ppam04151                   Pathway                                
Name
PI3K-Akt signaling pathway - Pteronotus mesoamericanus (Parnell's mustached bat)
Description
The phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, translation, proliferation, growth, and survival. The binding of growth factors to their receptor tyrosine kinase (RTK) or G protein-coupled receptors (GPCR) stimulates class Ia and Ib PI3K isoforms, respectively. PI3K catalyzes the production of phosphatidylinositol-3,4,5-triphosphate (PIP3) at the cell membrane. PIP3 in turn serves as a second messenger that helps to activate Akt. Once active, Akt can control key cellular processes by phosphorylating substrates involved in apoptosis, protein synthesis, metabolism, and cell cycle.
Class
Environmental Information Processing; Signal transduction
Pathway map
ppam04151  PI3K-Akt signaling pathway
ppam04151

Other DBs
GO: 0043491
Organism
Pteronotus mesoamericanus (Parnell's mustached bat) [GN:ppam]
Gene
129061268  IGF1R; insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
129061368  PSPN; persephin [KO:K25416]
129061374  EPOR; erythropoietin receptor [KO:K05079]
129061396  CDC37; hsp90 co-chaperone Cdc37 [KO:K09554]
129061427  PKN1; serine/threonine-protein kinase N1 [KO:K06071] [EC:2.7.11.13]
129061435  FGF2; LOW QUALITY PROTEIN: fibroblast growth factor 2 [KO:K18497]
129061444  IL2; interleukin-2 [KO:K05429]
129061574  NRTN; neurturin [KO:K25414]
129061625  TLR2; toll-like receptor 2 [KO:K10159]
129061630  ITGB6; integrin beta-6 isoform X1 [KO:K06589]
129061652  ITGA4; integrin alpha-4 isoform X1 [KO:K06483]
129061695  G6PC2; glucose-6-phosphatase 2 isoform X1 [KO:K01084] [EC:3.1.3.9]
129061773  ATF2; cyclic AMP-dependent transcription factor ATF-2 [KO:K04450]
129061828  ITGAV; integrin alpha-V isoform X1 [KO:K06487]
129061843  ITGA6; integrin alpha-6 isoform X1 [KO:K06485]
129062167  CRTC2; CREB-regulated transcription coactivator 2 isoform X1 [KO:K16333]
129062187  EFNA1; ephrin-A1 isoform X1 [KO:K05462]
129062200  ITGA10; integrin alpha-10 isoform X1 [KO:K06586]
129062297  IL6R; interleukin-6 receptor subunit alpha [KO:K05055]
129062329  THBS3; thrombospondin-3 [KO:K04659]
129062332  LAMB3; laminin subunit beta-3 [KO:K06244]
129062334  THEM4; acyl-coenzyme A thioesterase THEM4 isoform X1 [KO:K16339] [EC:3.1.2.2]
129062360  NTRK1; high affinity nerve growth factor receptor isoform X1 [KO:K03176] [EC:2.7.10.1]
129062388  CREB3L4; LOW QUALITY PROTEIN: cyclic AMP-responsive element-binding protein 3-like protein 4 [KO:K09048]
129062396  EFNA3; ephrin-A3 [KO:K05462]
129062397  EFNA4; ephrin-A4 isoform X1 [KO:K05462]
129062534  GNG14; putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347]
129062800  MAGI2; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 [KO:K05629]
129062841  CHRM2; muscarinic acetylcholine receptor M2 [KO:K04130]
129062851  CREB3L2; cyclic AMP-responsive element-binding protein 3-like protein 2 isoform X1 [KO:K09048]
129062886  COL1A2; collagen alpha-2(I) chain [KO:K06236]
129062922  PIK3CG; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform [KO:K21289] [EC:2.7.1.153]
129062953  GNGT1; guanine nucleotide-binding protein G(T) subunit gamma-T1 [KO:K04548]
129063060  RELN; reelin isoform X1 [KO:K06249] [EC:3.4.21.-]
129063111  CREB5; cyclic AMP-responsive element-binding protein 5 [KO:K09047]
129063240  ITGA11; integrin alpha-11 [KO:K06587]
129063288  LAMB1; laminin subunit beta-1 [KO:K05636]
129063382  MET; hepatocyte growth factor receptor isoform X1 [KO:K05099] [EC:2.7.10.1]
129063394  LAMB4; laminin subunit beta-4 [KO:K06245]
129063396  HGF; hepatocyte growth factor [KO:K05460]
129063424  ITGB8; integrin beta-8 [KO:K06591]
129063428  IL6; interleukin-6 [KO:K05405]
129063507  CDK6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
129063518  GNG11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
129063670  GNB5; guanine nucleotide-binding protein subunit beta-5 [KO:K04539]
129063699  CSF1; macrophage colony-stimulating factor 1 [KO:K05453]
129063946  NRAS; GTPase NRas [KO:K07828]
129063964  NGF; beta-nerve growth factor [KO:K02582]
129064134  [KO:K03099]
129064157  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
129064258  FGF7; fibroblast growth factor 7 [KO:K04358]
129064365  THBS1; thrombospondin-1 [KO:K16857]
129064694  FGF20; fibroblast growth factor 20 [KO:K04358]
129064790  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
129064807  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
129064817  EIF4EBP1; eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
129064836  PPP2CB; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
129064900  VEGFC; vascular endothelial growth factor C [KO:K05449]
129064909  ANGPT2; angiopoietin-2 [KO:K05466]
129064951  [KO:K06856]
129064979  FLT4; vascular endothelial growth factor receptor 3 [KO:K05097] [EC:2.7.10.1]
129064990  INSR; insulin receptor isoform X1 [KO:K04527] [EC:2.7.10.1]
129065155  [KO:K04079]
129065166  [KO:K04542]
129065324  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
129065344  LPAR4; lysophosphatidic acid receptor 4 [KO:K04275]
129065350  FGF16; fibroblast growth factor 16 [KO:K04358]
129065581  LPAR3; lysophosphatidic acid receptor 3 [KO:K04294]
129065733  PGF; placenta growth factor [KO:K16859]
129065975  PPP2R5E; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform isoform X1 [KO:K11584]
129066034  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
129066038  GNG2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 [KO:K07826]
129066065  [KO:K10167]
129066207  PPP2R5C; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X1 [KO:K11584]
129066210  HSP90AA1; heat shock protein HSP 90-alpha [KO:K04079]
129066231  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
129066327  IL4; interleukin-4 [KO:K05430]
129066330  [KO:K04736]
129066345  FGF18; fibroblast growth factor 18 [KO:K04358]
129066388  [KO:K04542]
129066389  [KO:K04542]
129066453  EIF4E1B; eukaryotic translation initiation factor 4E type 1B [KO:K03259]
129066457  FGFR4; fibroblast growth factor receptor 4 isoform X1 [KO:K05095] [EC:2.7.10.1]
129066549  PDGFRB; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
129066552  CSF1R; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
129066572  PPP2R2B; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform [KO:K04354]
129066585  FGF1; fibroblast growth factor 1 [KO:K18496]
129066683  PPP2CA; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
129067215  MYB; transcriptional activator Myb isoform X1 [KO:K09420]
129067337  TNXB; LOW QUALITY PROTEIN: tenascin-X [KO:K06252]
129067339  ATF6B; cyclic AMP-dependent transcription factor ATF-6 beta isoform X1 [KO:K09049]
129067419  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
129067448  CCND3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
129067464  PPP2R5D; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform [KO:K11584]
129067485  VEGFA; vascular endothelial growth factor A [KO:K05448]
129067491  HSP90AB1; heat shock protein HSP 90-beta [KO:K04079]
129067564  COL9A1; collagen alpha-1(IX) chain [KO:K08131]
129067683  YWHAQ; 14-3-3 protein theta [KO:K16197]
129067686  FOXO3; forkhead box protein O3 [KO:K09408]
129067709  LAMA4; laminin subunit alpha-4 isoform X1 [KO:K06241]
129067768  LAMA2; laminin subunit alpha-2 [KO:K05637]
129067792  SGK1; serine/threonine-protein kinase Sgk1 isoform X1 [KO:K13302] [EC:2.7.11.1]
129068119  CCNE1; G1/S-specific cyclin-E1 [KO:K06626]
129068140  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
129068211  RBL2; retinoblastoma-like protein 2 [KO:K16332]
129068332  FGF4; fibroblast growth factor 4 [KO:K04358]
129068333  FGF19; fibroblast growth factor 19 [KO:K22603]
129068425  CHRM1; muscarinic acetylcholine receptor M1 [KO:K04129]
129068458  FGF3; fibroblast growth factor 3 [KO:K04358]
129068502  INS; insulin [KO:K04526]
129068503  IGF2; insulin-like growth factor II isoform X1 [KO:K13769]
129068523  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
129068535  RPS6KB2; ribosomal protein S6 kinase beta-2 isoform X1 [KO:K04688] [EC:2.7.11.1]
129068571  RELA; transcription factor p65 [KO:K04735]
129068591  PPP2R5B; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform isoform X1 [KO:K11584]
129068612  BAD; bcl2-associated agonist of cell death [KO:K02158]
129068614  VEGFB; vascular endothelial growth factor B isoform X1 [KO:K16858]
129068639  GNG3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
129068705  PIK3R5; phosphoinositide 3-kinase regulatory subunit 5 isoform X1 [KO:K21290]
129068706  PIK3R6; phosphoinositide 3-kinase regulatory subunit 6 [KO:K21290]
129068799  COL6A3; collagen alpha-3(VI) chain [KO:K06238]
129068919  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
129068998  EIF4E2; eukaryotic translation initiation factor 4E type 2 isoform X1 [KO:K03259]
129069057  CSF3R; granulocyte colony-stimulating factor receptor isoform X1 [KO:K05061]
129069072  COL9A2; collagen alpha-2(IX) chain [KO:K08131]
129069104  ARTN; artemin isoform X1 [KO:K25415]
129069407  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
129069572  MTCP1; protein p13 MTCP-1 [KO:K16837]
129069640  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
129069750  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
129069849  [KO:K04542]
129069901  DDIT4; DNA damage-inducible transcript 4 protein [KO:K08270]
129070175  GH1; somatotropin [KO:K05438]
129070225  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
129070293  VTN; vitronectin [KO:K06251]
129070343  YWHAE; 14-3-3 protein epsilon isoform X1 [KO:K06630]
129070500  ANGPT4; angiopoietin-4 [KO:K05467]
129070603  PCK1; phosphoenolpyruvate carboxykinase, cytosolic [GTP] [KO:K01596] [EC:4.1.1.32]
129070674  YWHAB; 14-3-3 protein beta/alpha isoform X1 [KO:K16197]
129070681  PRKAA2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 isoform X1 [KO:K07198] [EC:2.7.11.31]
129070687  SGK2; serine/threonine-protein kinase Sgk2 isoform X1 [KO:K13303] [EC:2.7.11.1]
129070790  BCL2L1; bcl-2-like protein 1 isoform X1 [KO:K04570]
129071023  JAK1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
129071112  [KO:K05096] [EC:2.7.10.1]
129071133  IL2RG; cytokine receptor common subunit gamma [KO:K05070]
129071162  [KO:K04542]
129071213  COL4A2; collagen alpha-2(IV) chain [KO:K06237]
129071214  COL4A1; collagen alpha-1(IV) chain [KO:K06237]
129071253  IL2RB; interleukin-2 receptor subunit beta [KO:K05069]
129071284  NTF3; neurotrophin-3 [KO:K04356]
129071287  LPAR5; lysophosphatidic acid receptor 5 [KO:K08390]
129071314  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
129071373  HSP90B1; endoplasmin [KO:K09487]
129071377  IGF1; insulin-like growth factor I isoform X1 [KO:K05459]
129071415  VWF; von Willebrand factor [KO:K03900]
129071446  GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 isoform X1 [KO:K07825]
129071563  RPS6KB1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
129071582  ITGB3; integrin beta-3 isoform X1 [KO:K06493]
129071820  ITGB5; integrin beta-5 isoform X1 [KO:K06588]
129071959  FGF10; fibroblast growth factor 10 [KO:K04358]
129071984  ITGA1; integrin alpha-1 [KO:K06480]
129071985  ITGA2; integrin alpha-2 [KO:K06481]
129072028  MCL1; induced myeloid leukemia cell differentiation protein Mcl-1 [KO:K02539]
129072091  GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
129072137  BCL2L11; bcl-2-like protein 11 isoform X1 [KO:K16341]
129072290  TP53; cellular tumor antigen p53 [KO:K04451]
129072488  FGF22; LOW QUALITY PROTEIN: fibroblast growth factor 22 [KO:K04358]
129072575  PDGFC; platelet-derived growth factor C [KO:K05450]
129073033  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
129073113  HRAS; GTPase HRas isoform X1 [KO:K02833]
129073176  RET; proto-oncogene tyrosine-protein kinase receptor Ret isoform X1 [KO:K05126] [EC:2.7.10.1]
129073410  FLT3; receptor-type tyrosine-protein kinase FLT3 [KO:K05092] [EC:2.7.10.1]
129073492  FLT1; vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
129073753  [KO:K07298] [EC:2.7.11.1]
129073757  [KO:K07298] [EC:2.7.11.1]
129073871  LAMA5; laminin subunit alpha-5 [KO:K06240]
129073878  COL9A3; collagen alpha-3(IX) chain [KO:K08131]
129074148  PCK2; phosphoenolpyruvate carboxykinase [GTP], mitochondrial [KO:K01596] [EC:4.1.1.32]
129074177  IFNAR2; interferon alpha/beta receptor 2 isoform X1 [KO:K05131]
129074194  IFNAR1; interferon alpha/beta receptor 1 [KO:K05130]
129074223  FGF23; fibroblast growth factor 23 [KO:K22428]
129074224  FGF6; fibroblast growth factor 6 [KO:K04358]
129074231  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
129074288  [KO:K04542]
129074378  IKBKG; NF-kappa-B essential modulator [KO:K07210]
129074590  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
129074626  F2R; proteinase-activated receptor 1 [KO:K03914]
129074648  THBS4; thrombospondin-4 [KO:K04659]
129074836  JAK3; tyrosine-protein kinase JAK3 [KO:K11218] [EC:2.7.10.2]
129074855  COMP; cartilage oligomeric matrix protein isoform X1 [KO:K04659]
129074864  LPAR2; lysophosphatidic acid receptor 2 [KO:K04291]
129074873  FGF17; fibroblast growth factor 17 isoform X1 [KO:K04358]
129074969  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
129075024  PPP2R2A; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X1 [KO:K04354]
129075217  PHLPP2; PH domain leucine-rich repeat-containing protein phosphatase 2 [KO:K16340] [EC:3.1.3.16]
129075246  COL6A1; collagen alpha-1(VI) chain [KO:K06238]
129075254  COL6A2; collagen alpha-2(VI) chain isoform X1 [KO:K06238]
129075586  CASP9; caspase-9 [KO:K04399] [EC:3.4.22.62]
129075629  EPHA2; ephrin type-A receptor 2 [KO:K05103] [EC:2.7.10.1]
129075656  MTOR; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
129075675  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
129075763  ERBB3; receptor tyrosine-protein kinase erbB-3 isoform X1 [KO:K05084] [EC:2.7.10.1]
129075823  CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
129075868  MDM2; E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:2.3.2.27]
129075936  KITLG; kit ligand isoform X1 [KO:K05461]
129076186  COL4A5; collagen alpha-5(IV) chain [KO:K06237]
129076222  [KO:K06237]
129076231  [KO:K03258]
129076239  [KO:K04079]
129076577  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
129076641  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
129076697  GNB4; guanine nucleotide-binding protein subunit beta-4 [KO:K04538]
129076927  [KO:K04079]
129076969  VEGFD; vascular endothelial growth factor D [KO:K05449]
129077075  PIK3AP1; phosphoinositide 3-kinase adapter protein 1 [KO:K12230]
129077110  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
129077188  [KO:K04542]
129077222  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
129077291  FGF8; fibroblast growth factor 8 isoform X1 [KO:K04358]
129077479  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
129077631  PDGFRA; platelet-derived growth factor receptor alpha isoform X1 [KO:K04363] [EC:2.7.10.1]
129077640  KIT; mast/stem cell growth factor receptor Kit isoform X1 [KO:K05091] [EC:2.7.10.1]
129077642  KDR; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
129077675  PPP2R2C; protein phosphatase 2, regulatory subunit B, gamma isoform X1 [KO:K04354]
129077762  ITGB1; integrin beta-1 isoform X1 [KO:K05719]
129077794  [KO:K04543]
129077836  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
129077932  PDGFB; platelet-derived growth factor subunit B [KO:K17386]
129077993  [KO:K05071]
129078069  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
129078086  CD19; LOW QUALITY PROTEIN: B-lymphocyte antigen CD19 [KO:K06465]
129078096  IL4R; interleukin-4 receptor subunit alpha [KO:K05071]
129078155  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
129078156  CREB3L3; cyclic AMP-responsive element-binding protein 3-like protein 3 isoform X1 [KO:K09048]
129078231  NTRK2; BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
129078300  JAK2; tyrosine-protein kinase JAK2 [KO:K04447] [EC:2.7.10.2]
129078347  RPS6; 40S ribosomal protein S6 [KO:K02991]
129078413  [KO:K04392]
129078454  IFNB1; interferon beta [KO:K05415]
129078455  [KO:K05414]
129078645  LAMA3; laminin subunit alpha-3 isoform X1 [KO:K06240]
129078763  PHLPP1; PH domain leucine-rich repeat-containing protein phosphatase 1 [KO:K16340] [EC:3.1.3.16]
129078764  BCL2; apoptosis regulator Bcl-2 isoform X1 [KO:K02161]
129078986  PRLR; prolactin receptor [KO:K05081]
129078988  IL7R; interleukin-7 receptor subunit alpha [KO:K05072]
129079006  PRKAA1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 [KO:K07198] [EC:2.7.11.31]
129079016  GHR; growth hormone receptor isoform X1 [KO:K05080]
129079053  GDNF; glial cell line-derived neurotrophic factor isoform X1 [KO:K05452]
129079133  GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
129079171  RXRA; retinoic acid receptor RXR-alpha isoform X1 [KO:K08524]
129079187  TSC1; hamartin isoform X1 [KO:K07206]
129079228  PKN3; serine/threonine-protein kinase N3 isoform X1 [KO:K23692]
129079317  TLR4; toll-like receptor 4 [KO:K10160]
129079351  GNG10; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
129079355  LPAR1; lysophosphatidic acid receptor 1 [KO:K04289]
129079431  CREB3; cyclic AMP-responsive element-binding protein 3 isoform X1 [KO:K09048]
129079570  LAMC3; laminin subunit gamma-3 [KO:K06247]
129079622  TNC; tenascin [KO:K06252]
129079755  PPP2R3B; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta isoform X1 [KO:K11583]
129079762  IL3RA; interleukin-3 receptor subunit alpha [KO:K04737]
129079776  PPP2R2D; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform isoform X1 [KO:K04354]
129079949  [KO:K04079]
129080087  EFNA2; ephrin-A2 [KO:K05462]
129080121  GNGT2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 [KO:K04549]
129080131  ITGA3; integrin alpha-3 isoform X1 [KO:K06482]
129080141  CHAD; chondroadherin [KO:K06248]
129080218  NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
129080225  COL1A1; collagen alpha-1(I) chain [KO:K06236]
129080301  COL4A3; collagen alpha-3(IV) chain [KO:K06237]
129080303  COL4A4; collagen alpha-4(IV) chain [KO:K06237]
129080305  IRS1; insulin receptor substrate 1 [KO:K16172]
129080366  FN1; fibronectin isoform X1 [KO:K05717]
129080370  ERBB4; receptor tyrosine-protein kinase erbB-4 [KO:K05085] [EC:2.7.10.1]
129080390  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
129080496  BDNF; brain-derived neurotrophic factor [KO:K04355]
129080730  [KO:K04079]
129080867  LPAR6; lysophosphatidic acid receptor 6 [KO:K04273]
129081344  GNG7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543]
129081363  TGFA; protransforming growth factor alpha [KO:K08774]
129081448  PPP2R3C; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma [KO:K11583]
129081516  CREB3L1; cyclic AMP-responsive element-binding protein 3-like protein 1 [KO:K09048]
129081552  PPP2R1A; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform [KO:K03456]
129081686  LAMA1; laminin subunit alpha-1 [KO:K05637]
129081861  TNN; tenascin-N [KO:K06252]
129081875  LAMC2; laminin subunit gamma-2 [KO:K06246]
129081897  TNR; tenascin-R [KO:K06252]
129081899  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
129081950  PPP2R5A; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform [KO:K11584]
129081987  LAMC1; laminin subunit gamma-1 [KO:K05635]
129082282  [KO:K04079]
129082327  FGF9; fibroblast growth factor 9 [KO:K04358]
129082351  SYK; tyrosine-protein kinase SYK isoform X1 [KO:K05855] [EC:2.7.10.2]
129082381  TEK; angiopoietin-1 receptor isoform X1 [KO:K05121] [EC:2.7.10.1]
129082769  GNG8; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 [KO:K04544]
129082796  FGF21; fibroblast growth factor 21 [KO:K22429]
129082804  FLT3LG; fms-related tyrosine kinase 3 ligand isoform X1 [KO:K05454]
129082915  GYS1; glycogen [starch] synthase, muscle [KO:K00693] [EC:2.4.1.11]
129082927  NTF4; neurotrophin-4 [KO:K12457]
129083348  GNG13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547]
129083454  EPO; erythropoietin [KO:K05437]
129083598  TSC2; tuberin isoform X1 [KO:K07207]
129083602  MLST8; target of rapamycin complex subunit LST8 isoform X1 [KO:K08266]
129083615  PDPK1; 3-phosphoinositide-dependent protein kinase 1 isoform X1 [KO:K06276] [EC:2.7.11.1]
129083794  YWHAG; 14-3-3 protein gamma [KO:K16198]
129083812  GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
129083921  [KO:K04079]
129083924  EFNA5; ephrin-A5 isoform X1 [KO:K05462]
129084020  [KO:K04542]
129084081  MYC; myc proto-oncogene protein [KO:K04377]
129084108  FGF5; fibroblast growth factor 5 [KO:K04358]
129084181  SGK3; serine/threonine-protein kinase Sgk3 [KO:K13304] [EC:2.7.11.1]
129084214  CCNE2; G1/S-specific cyclin-E2 [KO:K06626]
129084246  YWHAZ; 14-3-3 protein zeta/delta [KO:K16197]
129084274  ANGPT1; angiopoietin-1 isoform X1 [KO:K05465]
129084348  PTK2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
129084544  IL2RA; interleukin-2 receptor subunit alpha [KO:K05068]
129084680  COL2A1; collagen alpha-1(II) chain [KO:K19719]
129084761  [KO:K04542]
129084786  ITGA7; integrin alpha-7 isoform X1 [KO:K06583]
129084791  ITGA5; integrin alpha-5 [KO:K06484]
129084815  ITGB7; integrin beta-7 [KO:K06590]
129084823  EIF4B; eukaryotic translation initiation factor 4B isoform X1 [KO:K03258]
129084834  NR4A1; nuclear receptor subfamily 4 group A member 1 [KO:K04465]
129084969  KRAS; GTPase KRas isoform X1 [KO:K07827]
129084980  GYS2; glycogen [starch] synthase, liver [KO:K00693] [EC:2.4.1.11]
129085013  CDKN1B; cyclin-dependent kinase inhibitor 1B [KO:K06624]
129085194  SPP1; osteopontin [KO:K06250]
129085197  IBSP; bone sialoprotein 2 [KO:K06253]
129085245  AREG; amphiregulin [KO:K09782]
129085287  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
129085322  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
129085338  EIF4E; eukaryotic translation initiation factor 4E [KO:K03259]
129085648  PRL; prolactin isoform X1 [KO:K05439]
129085676  PKN2; serine/threonine-protein kinase N2 [KO:K23691]
129085846  [KO:K04079]
129085896  [KO:K04542]
129085920  [KO:K04079]
129086002  PPP2R1B; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X1 [KO:K03456]
129086014  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
129086248  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
129086587  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
129086601  ITGA2B; integrin alpha-IIb [KO:K06476]
129086631  RPTOR; regulatory-associated protein of mTOR [KO:K07204]
129086641  ITGB4; integrin beta-4 isoform X1 [KO:K06525]
129086656  G6PC3; glucose-6-phosphatase 3 isoform X1 [KO:K01084] [EC:3.1.3.9]
129086739  ITGA8; integrin alpha-8 [KO:K06584]
129086753  NOS3; nitric oxide synthase, endothelial [KO:K13242] [EC:1.14.13.39]
129086755  RHEB; GTP-binding protein Rheb [KO:K07208]
129086886  G6PC1; glucose-6-phosphatase catalytic subunit 1 [KO:K01084] [EC:3.1.3.9]
129086900  BRCA1; LOW QUALITY PROTEIN: breast cancer type 1 susceptibility protein [KO:K10605] [EC:2.3.2.27]
129087036  ERBB2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
129087056  CSF3; LOW QUALITY PROTEIN: granulocyte colony-stimulating factor [KO:K05423]
129087277  OSM; oncostatin-M [KO:K05418]
129087483  YWHAH; 14-3-3 protein eta [KO:K16198]
129087491  EREG; proepiregulin [KO:K09784]
129087768  LAMB2; laminin subunit beta-2 [KO:K06243]
129087898  THBS2; thrombospondin-2 [KO:K04659]
129087914  [KO:K06238]
129088187  PPP2R3A; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha isoform X1 [KO:K11583]
129088203  MAGI1; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X1 [KO:K05631]
129088223  ITGA9; integrin alpha-9 [KO:K06585]
129088291  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
129088356  IL7; interleukin-7 [KO:K05431]
129088374  COL6A5; collagen alpha-5(VI) chain [KO:K06238]
129088409  COL6A6; collagen alpha-6(VI) chain [KO:K06238]
129088423  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
Compound
C00020  AMP
C00533  Nitric oxide
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:16847462
  Authors
Engelman JA, Luo J, Cantley LC
  Title
The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism.
  Journal
Nat Rev Genet 7:606-19 (2006)
DOI:10.1038/nrg1879
Reference
PMID:15784165
  Authors
Song G, Ouyang G, Bao S
  Title
The activation of Akt/PKB signaling pathway and cell survival.
  Journal
J Cell Mol Med 9:59-71 (2005)
DOI:10.1111/j.1582-4934.2005.tb00337.x
Reference
PMID:21620960
  Authors
Hers I, Vincent EE, Tavare JM
  Title
Akt signalling in health and disease.
  Journal
Cell Signal 23:1515-27 (2011)
DOI:10.1016/j.cellsig.2011.05.004
Reference
PMID:18842113
  Authors
Duronio V
  Title
The life of a cell: apoptosis regulation by the PI3K/PKB pathway.
  Journal
Biochem J 415:333-44 (2008)
DOI:10.1042/BJ20081056
Reference
PMID:16248975
  Authors
Kim D, Chung J.
  Title
Akt: versatile mediator of cell survival and beyond.
  Journal
J Biochem Mol Biol 35:106-15 (2002)
DOI:10.5483/bmbrep.2002.35.1.106
Reference
PMID:12660731
  Authors
Koyasu S
  Title
The role of PI3K in immune cells.
  Journal
Nat Immunol 4:313-9 (2003)
DOI:10.1038/ni0403-313
Reference
PMID:12669022
  Authors
Okkenhaug K, Vanhaesebroeck B.
  Title
PI3K in lymphocyte development, differentiation and activation.
  Journal
Nat Rev Immunol 3:317-30 (2003)
DOI:10.1038/nri1056
Reference
PMID:15209374
  Authors
Richardson CJ, Schalm SS, Blenis J
  Title
PI3-kinase and TOR: PIKTORing cell growth.
  Journal
Semin Cell Dev Biol 15:147-59 (2004)
DOI:10.1016/j.semcdb.2003.12.023
Reference
PMID:21440011
  Authors
Zhang X, Tang N, Hadden TJ, Rishi AK
  Title
Akt, FoxO and regulation of apoptosis.
  Journal
Biochim Biophys Acta 1813:1978-86 (2011)
DOI:10.1016/j.bbamcr.2011.03.010
Reference
PMID:21779440
  Authors
Georgescu MM
  Title
PTEN Tumor Suppressor Network in PI3K-Akt Pathway Control.
  Journal
Genes Cancer 1:1170-7 (2010)
DOI:10.1177/1947601911407325
Reference
PMID:12531180
  Authors
West KA, Castillo SS, Dennis PA
  Title
Activation of the PI3K/Akt pathway and chemotherapeutic resistance.
  Journal
Drug Resist Updat 5:234-48 (2002)
DOI:10.1016/S1368-7646(02)00120-6
Reference
PMID:9838078
  Authors
Wymann MP, Pirola L
  Title
Structure and function of phosphoinositide 3-kinases.
  Journal
Biochim Biophys Acta 1436:127-50 (1998)
DOI:10.1016/S0005-2760(98)00139-8
Reference
PMID:12048182
  Authors
Moelling K, Schad K, Bosse M, Zimmermann S, Schweneker M
  Title
Regulation of Raf-Akt Cross-talk.
  Journal
J Biol Chem 277:31099-106 (2002)
DOI:10.1074/jbc.M111974200
Reference
PMID:16187290
  Authors
Kikani CK, Dong LQ, Liu F
  Title
"New"-clear functions of PDK1: beyond a master kinase in the cytosol?
  Journal
J Cell Biochem 96:1157-62 (2005)
DOI:10.1002/jcb.20651
Reference
PMID:11357143
  Authors
Blume-Jensen P, Hunter T
  Title
Oncogenic kinase signalling.
  Journal
Nature 411:355-65 (2001)
DOI:10.1038/35077225
Reference
PMID:15505410
  Authors
Osaki M, Oshimura M, Ito H
  Title
PI3K-Akt pathway: its functions and alterations in human cancer.
  Journal
Apoptosis 9:667-76 (2004)
DOI:10.1023/B:APPT.0000045801.15585.dd
Reference
PMID:17360849
  Authors
Noguchi M, Ropars V, Roumestand C, Suizu F
  Title
Proto-oncogene TCL1: more than just a coactivator for Akt.
  Journal
FASEB J 21:2273-84 (2007)
DOI:10.1096/fj.06-7684com
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Related
pathway
ppam00010  Glycolysis / Gluconeogenesis
ppam04010  MAPK signaling pathway
ppam04012  ErbB signaling pathway
ppam04062  Chemokine signaling pathway
ppam04064  NF-kappa B signaling pathway
ppam04068  FoxO signaling pathway
ppam04110  Cell cycle
ppam04115  p53 signaling pathway
ppam04150  mTOR signaling pathway
ppam04210  Apoptosis
ppam04370  VEGF signaling pathway
ppam04510  Focal adhesion
ppam04620  Toll-like receptor signaling pathway
ppam04630  JAK-STAT signaling pathway
ppam04662  B cell receptor signaling pathway
ppam04910  Insulin signaling pathway
KO pathway
ko04151   

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