KEGG   PATHWAY: tmu04014
Entry
tmu04014                    Pathway                                
Name
Ras signaling pathway - Trichechus manatus latirostris (Florida manatee)
Description
The Ras proteins are GTPases that function as molecular switches for signaling pathways regulating cell proliferation, survival, growth, migration, differentiation or cytoskeletal dynamism. Ras proteins transduce signals from extracellular growth factors by cycling between inactive GDP-bound and active GTP-bound states. The exchange of GTP for GDP on RAS is regulated by guanine nucleotide exchange factors (GEFs) and GTPase-activating proteins (GAPs). Activated RAS (RAS-GTP) regulates multiple cellular functions through effectors including Raf, phosphatidylinositol 3-kinase (PI3K) and Ral guanine nucleotide-dissociation stimulator (RALGDS).
Class
Environmental Information Processing; Signal transduction
Pathway map
tmu04014  Ras signaling pathway
tmu04014

Other DBs
GO: 0032318
Organism
Trichechus manatus latirostris (Florida manatee) [GN:tmu]
Gene
101355971  pro-epidermal growth factor [KO:K04357]
101355918  protransforming growth factor alpha isoform X1 [KO:K08774]
101359380  fibroblast growth factor 1 isoform X1 [KO:K18496]
101342442  LOW QUALITY PROTEIN: fibroblast growth factor 2 [KO:K18497]
101347308  fibroblast growth factor 8 isoform X3 [KO:K04358]
101361747  fibroblast growth factor 18 [KO:K04358]
101360972  fibroblast growth factor 9 [KO:K04358]
101344975  fibroblast growth factor 20 [KO:K04358]
101357665  fibroblast growth factor 7 [KO:K04358]
101348610  fibroblast growth factor 16 [KO:K04358]
101356322  fibroblast growth factor 17 isoform X1 [KO:K04358]
101356591  fibroblast growth factor 10 [KO:K04358]
101353258  fibroblast growth factor 3 [KO:K04358]
101350986  fibroblast growth factor 6 [KO:K04358]
101351769  fibroblast growth factor 22 [KO:K04358]
101347190  fibroblast growth factor 5 isoform X1 [KO:K04358]
101354028  fibroblast growth factor 19 [KO:K22603]
101356236  fibroblast growth factor 21 [KO:K22429]
101351251  fibroblast growth factor 23 [KO:K22428]
101341922  beta-nerve growth factor [KO:K02582]
101350169  brain-derived neurotrophic factor isoform X1 [KO:K04355]
101349059  neurotrophin-3 [KO:K04356]
101355026  neurotrophin-4 [KO:K12457]
101346705  insulin [KO:K04526]
101361934  insulin-like growth factor I isoform X1 [KO:K05459]
101344666  platelet-derived growth factor subunit A [KO:K04359]
101344115  platelet-derived growth factor subunit B [KO:K17386]
101358075  platelet-derived growth factor C isoform X1 [KO:K05450]
101360702  platelet-derived growth factor D [KO:K05450]
101357438  macrophage colony-stimulating factor 1 isoform X3 [KO:K05453]
101350740  kit ligand [KO:K05461]
101352641  fms-related tyrosine kinase 3 ligand isoform X2 [KO:K05454]
101341920  vascular endothelial growth factor A [KO:K05448]
101352912  vascular endothelial growth factor B [KO:K16858]
101355158  placenta growth factor isoform X1 [KO:K16859]
101344331  vascular endothelial growth factor D [KO:K05449]
101360380  vascular endothelial growth factor C [KO:K05449]
101344799  hepatocyte growth factor isoform X3 [KO:K05460]
101344008  angiopoietin-1 isoform X1 [KO:K05465]
101341636  angiopoietin-2 [KO:K05466]
101342215  angiopoietin-4 [KO:K05467]
101354975  ephrin-A4 [KO:K05462]
101355486  ephrin-A1 isoform X1 [KO:K05462]
101355917  ephrin-A3 isoform X1 [KO:K05462]
101347678  ephrin-A2 [KO:K05462]
101345541  ephrin-A5 [KO:K05462]
101356822  epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
101342270  fibroblast growth factor receptor 1 isoform X2 [KO:K04362] [EC:2.7.10.1]
101357035  fibroblast growth factor receptor 2 isoform X6 [KO:K05093] [EC:2.7.10.1]
101341002  fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
101344195  fibroblast growth factor receptor 4 isoform X1 [KO:K05095] [EC:2.7.10.1]
101358935  tumor necrosis factor receptor superfamily member 16 isoform X1 [KO:K02583]
101351378  high affinity nerve growth factor receptor isoform X2 [KO:K03176] [EC:2.7.10.1]
101342178  BDNF/NT-3 growth factors receptor isoform X5 [KO:K04360] [EC:2.7.10.1]
101360415  insulin receptor [KO:K04527] [EC:2.7.10.1]
101355333  insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
101348884  platelet-derived growth factor receptor alpha isoform X1 [KO:K04363] [EC:2.7.10.1]
101360003  platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
101360266  macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
101357486  mast/stem cell growth factor receptor Kit [KO:K05091] [EC:2.7.10.1]
101352048  receptor-type tyrosine-protein kinase FLT3 isoform X2 [KO:K05092] [EC:2.7.10.1]
101352737  vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
101340931  vascular endothelial growth factor receptor 3 [KO:K05097] [EC:2.7.10.1]
101348626  vascular endothelial growth factor receptor 2 isoform X1 [KO:K05098] [EC:2.7.10.1]
101345595  hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
101351895  angiopoietin-1 receptor isoform X1 [KO:K05121] [EC:2.7.10.1]
101355264  ephrin type-A receptor 2 [KO:K05103] [EC:2.7.10.1]
101359012  growth factor receptor-bound protein 2 [KO:K04364]
101355014  GRB2-associated-binding protein 1 isoform X1 [KO:K09593]
101346505  GRB2-associated-binding protein 2 [KO:K08091]
101358105  SHC-transforming protein 1 isoform X1 [KO:K06279]
101359726  SHC-transforming protein 2 [KO:K17447]
101360084  SHC-transforming protein 3 [KO:K17448]
101355900  SHC-transforming protein 4 [KO:K17449]
101348102  tyrosine-protein phosphatase non-receptor type 11 isoform X2 [KO:K07293] [EC:3.1.3.48]
101359592  son of sevenless homolog 1 isoform X1 [KO:K03099]
101347392  son of sevenless homolog 2 isoform X1 [KO:K03099]
101359597  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X2 [KO:K01116] [EC:3.1.4.11]
101346393  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 isoform X1 [KO:K05859] [EC:3.1.4.11]
101343790  RAS guanyl-releasing protein 1 isoform X1 [KO:K04350]
101347941  RAS guanyl-releasing protein 2 [KO:K12361]
101360110  ras guanyl-releasing protein 3 [KO:K12362]
101351284  RAS guanyl-releasing protein 4 [KO:K12363]
111819117  uncharacterized protein LOC111819117 [KO:K10784]
101361451  LOW QUALITY PROTEIN: uncharacterized protein LOC101361451 [KO:K10785]
105756611  uncharacterized protein LOC105756611 [KO:K10785]
101342429  uncharacterized protein LOC101342429 [KO:K10785]
101347632  tyrosine-protein kinase ZAP-70 [KO:K07360] [EC:2.7.10.2]
101356413  linker for activation of T-cells family member 1 isoform X2 [KO:K07362]
101359419  5-hydroxytryptamine receptor 7 [KO:K04163]
101350742  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
101345319  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
101355136  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 [KO:K07825]
101348280  guanine nucleotide-binding protein subunit beta-4 [KO:K04538]
101341327  guanine nucleotide-binding protein subunit beta-5 [KO:K04539]
101352593  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 isoform X1 [KO:K07826]
101342107  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
101357541  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
101345326  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
101347845  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 isoform X2 [KO:K04543]
111821467  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 [KO:K04544]
111819711  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
101341777  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
101351188  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
111819060  putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347]
101351136  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547]
101342034  guanine nucleotide-binding protein G(T) subunit gamma-T1 [KO:K04548]
101360148  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 [KO:K04549]
101342638  cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
101348995  cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
101361974  ras-specific guanine nucleotide-releasing factor 1 isoform X1 [KO:K04349]
101351582  ras-specific guanine nucleotide-releasing factor 2 [KO:K12326]
101349517  glutamate receptor ionotropic, NMDA 1 isoform X1 [KO:K05208]
101353799  glutamate receptor ionotropic, NMDA 2A isoform X1 [KO:K05209]
101340402  glutamate receptor ionotropic, NMDA 2B [KO:K05210]
101347126  calmodulin-2 isoform X2 [KO:K02183]
101361121  LOW QUALITY PROTEIN: calmodulin-like protein 6 [KO:K02183]
101358846  LOW QUALITY PROTEIN: calmodulin-like protein 3 [KO:K02183]
101346240  calmodulin-3 [KO:K02183]
101358487  calmodulin [KO:K02183]
101346473  calmodulin-like protein 4 [KO:K02183]
101359111  calmodulin-like [KO:K02183]
101342804  GTPase HRas isoform X2 [KO:K02833]
101347525  GTPase KRas isoform X3 [KO:K07827]
101344230  GTPase NRas isoform X1 [KO:K07828]
101357647  ras-related protein M-Ras isoform X1 [KO:K07831]
101349553  ras-related protein R-Ras [KO:K07829]
101354889  ras-related protein R-Ras2 [KO:K07830]
101341602  neurofibromin isoform X1 [KO:K08052]
101359278  ras GTPase-activating protein 1 [KO:K04352]
101344154  ras GTPase-activating protein 2 isoform X2 [KO:K08053]
101361309  ras GTPase-activating protein 3 [KO:K12380]
101347110  ras GTPase-activating protein 4B isoform X1 [KO:K17630]
101340944  ras/Rap GTPase-activating protein SynGAP [KO:K17631]
101343782  rasGAP-activating-like protein 1 isoform X1 [KO:K17632]
101349608  ras GTPase-activating protein nGAP isoform X2 [KO:K17633]
101357914  RAS protein activator like-3 [KO:K17634]
101343214  ras association domain-containing protein 1 isoform X3 [KO:K09850]
101344376  ras association domain-containing protein 5 isoform X1 [KO:K08015]
101351731  serine/threonine-protein kinase 4 isoform X1 [KO:K04411]
101352570  T-lymphoma invasion and metastasis-inducing protein 1 isoform X1 [KO:K05731]
101356054  ras-related C3 botulinum toxin substrate 1 [KO:K04392]
101355428  ras-related C3 botulinum toxin substrate 2 isoform X1 [KO:K07860]
101360313  ras-related C3 botulinum toxin substrate 3 [KO:K07861]
101343358  serine/threonine-protein kinase PAK 1 isoform X1 [KO:K04409] [EC:2.7.11.1]
101355178  serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
101352984  serine/threonine-protein kinase PAK 3 isoform X1 [KO:K05733] [EC:2.7.11.1]
101358969  serine/threonine-protein kinase PAK 4 isoform X2 [KO:K05734] [EC:2.7.11.1]
101361889  serine/threonine-protein kinase PAK 5 [KO:K05736] [EC:2.7.11.1]
101346499  serine/threonine-protein kinase PAK 6 isoform X1 [KO:K05735] [EC:2.7.11.1]
101356840  transforming protein RhoA [KO:K04513]
101358678  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
101346849  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
101359658  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X2 [KO:K00922] [EC:2.7.1.153]
101351035  phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
101343804  phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
101347746  phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
101360493  RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
101356099  RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
101350197  RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
101347574  NF-kappa-B essential modulator isoform X1 [KO:K07210]
101341290  inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
101351256  inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
101351866  nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
101361706  transcription factor p65 [KO:K04735]
101352047  bcl2-associated agonist of cell death [KO:K02158]
101346361  bcl-2-like protein 1 isoform X1 [KO:K04570]
101358942  forkhead box protein O4 [KO:K12358]
101344408  tumor necrosis factor ligand superfamily member 6 isoform X1 [KO:K04389]
101353910  ral GTPase-activating protein subunit alpha-1 isoform X5 [KO:K25768]
101355352  ral GTPase-activating protein subunit alpha-2 isoform X1 [KO:K25768]
101361318  ral GTPase-activating protein subunit beta isoform X1 [KO:K25769]
101348938  ral guanine nucleotide dissociation stimulator isoform X1 [KO:K08732]
101348205  LOW QUALITY PROTEIN: ral guanine nucleotide dissociation stimulator-like [KO:K08732]
101349734  LOW QUALITY PROTEIN: ral guanine nucleotide dissociation stimulator-like [KO:K08732]
101351825  ral guanine nucleotide dissociation stimulator-like [KO:K08732]
101361756  ral guanine nucleotide dissociation stimulator-like 1 isoform X1 [KO:K17635]
101351985  ral guanine nucleotide dissociation stimulator-like 2 [KO:K17636]
101354107  ras-related protein Ral-A [KO:K07834]
101342129  ras-related protein Ral-B [KO:K07835]
101343866  phospholipase D2 [KO:K01115] [EC:3.1.4.4]
101358169  phospholipase D1 isoform X1 [KO:K01115] [EC:3.1.4.4]
101350243  exocyst complex component 2 isoform X1 [KO:K17637]
101345902  serine/threonine-protein kinase TBK1 isoform X3 [KO:K05410] [EC:2.7.11.10]
101357849  proto-oncogene c-Rel isoform X1 [KO:K09254]
101351734  mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
101351967  mitogen-activated protein kinase 9 isoform X2 [KO:K04440] [EC:2.7.11.24]
101343546  mitogen-activated protein kinase 8 isoform X4 [KO:K04440] [EC:2.7.11.24]
101348127  ralA-binding protein 1 [KO:K08773]
101361943  cell division control protein 42 homolog isoform X1 [KO:K04393]
101361049  afadin [KO:K05702]
101343685  leucine-rich repeat protein SHOC-2 [KO:K19613]
101357840  RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
101343332  dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
101341078  dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
101340589  mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
101358526  mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
101349358  phospholipase A1 member A [KO:K13618] [EC:3.1.1.111]
101357063  group XIIB secretory phospholipase A2-like protein isoform X1 [KO:K01047] [EC:3.1.1.4]
101340958  group 10 secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
101350719  putative inactive group IIC secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
101350972  group IIF secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
101351238  calcium-dependent phospholipase A2 [KO:K01047] [EC:3.1.1.4]
101351497  phospholipase A2, membrane associated [KO:K01047] [EC:3.1.1.4]
101359028  phospholipase A2 [KO:K01047] [EC:3.1.1.4]
101345796  phospholipase A2, membrane associated-like [KO:K01047] [EC:3.1.1.4]
101346575  group IID secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
101346825  group IIE secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
101348013  group XIIA secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
101358673  group 3 secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
101345270  cytosolic phospholipase A2 isoform X1 [KO:K16342] [EC:3.1.1.4]
101354943  cytosolic phospholipase A2 epsilon [KO:K16342] [EC:3.1.1.4]
101355199  cytosolic phospholipase A2 zeta [KO:K16342] [EC:3.1.1.4]
101352550  cytosolic phospholipase A2 beta [KO:K16342] [EC:3.1.1.4]
101353066  cytosolic phospholipase A2 delta [KO:K16342] [EC:3.1.1.4]
101345872  85/88 kDa calcium-independent phospholipase A2 isoform X1 [KO:K16343] [EC:3.1.1.4]
101358172  HRAS-like suppressor 3 isoform X1 [KO:K16817] [EC:3.1.1.32 3.1.1.4]
101352015  ETS domain-containing protein Elk-1 [KO:K04375]
101342007  protein C-ets-1 isoform X2 [KO:K02678]
101356760  protein C-ets-2 isoform X1 [KO:K21932]
101350568  BRCA1-associated protein [KO:K10632] [EC:2.3.2.27]
101340925  kinase suppressor of Ras 1 [KO:K14958]
101341745  kinase suppressor of Ras 2 [KO:K18529] [EC:2.7.11.1]
101356550  rap guanine nucleotide exchange factor 5 isoform X1 [KO:K08019]
101352801  ras-related protein Rap-1A [KO:K04353]
101348129  ras-related protein Rap-1b [KO:K07836]
101349251  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 [KO:K05860] [EC:3.1.4.11]
101348250  protein kinase C alpha type isoform X2 [KO:K02677] [EC:2.7.11.13]
101356454  protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
101351254  protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
101359132  ras and Rab interactor 1 [KO:K17638]
101341732  tyrosine-protein kinase ABL1 isoform X1 [KO:K06619] [EC:2.7.10.2]
101351045  Abelson tyrosine-protein kinase 2 isoform X1 [KO:K08887] [EC:2.7.10.2]
101358523  ras-related protein Rab-5A [KO:K07887]
101355194  ras-related protein Rab-5B [KO:K07888]
101354649  ras-related protein Rab-5C [KO:K07889]
101346710  ADP-ribosylation factor 6 [KO:K07941]
Compound
C00035  GDP
C00044  GTP
C00076  Calcium cation
C00165  Diacylglycerol
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:18568040
  Authors
Karnoub AE, Weinberg RA
  Title
Ras oncogenes: split personalities.
  Journal
Nat Rev Mol Cell Biol 9:517-31 (2008)
DOI:10.1038/nrm2438
Reference
PMID:12778136
  Authors
Malumbres M, Barbacid M
  Title
RAS oncogenes: the first 30 years.
  Journal
Nat Rev Cancer 3:459-65 (2003)
DOI:10.1038/nrc1097
Reference
PMID:21686117
  Authors
Cox AD, Der CJ
  Title
Ras history: The saga continues.
  Journal
Small GTPases 1:2-27 (2010)
DOI:10.4161/sgtp.1.1.12178
Reference
PMID:12642680
  Authors
Cox AD, Der CJ
  Title
Ras family signaling: therapeutic targeting.
  Journal
Cancer Biol Ther 1:599-606 (2002)
DOI:10.4161/cbt.306
Reference
PMID:17428555
  Authors
Rajalingam K, Schreck R, Rapp UR, Albert S
  Title
Ras oncogenes and their downstream targets.
  Journal
Biochim Biophys Acta 1773:1177-95 (2007)
DOI:10.1016/j.bbamcr.2007.01.012
Reference
PMID:17384584
  Authors
Schubbert S, Shannon K, Bollag G
  Title
Hyperactive Ras in developmental disorders and cancer.
  Journal
Nat Rev Cancer 7:295-308 (2007)
DOI:10.1038/nrc2109
Reference
PMID:22233291
  Authors
Poulogiannis G, Luo F, Arends MJ
  Title
RAS signalling in the colorectum in health and disease.
  Journal
Cell Commun Adhes 19:1-9 (2012)
DOI:10.3109/15419061.2011.649380
Reference
PMID:22020205
  Authors
Berndt N, Hamilton AD, Sebti SM
  Title
Targeting protein prenylation for cancer therapy.
  Journal
Nat Rev Cancer 11:775-91 (2011)
DOI:10.1038/nrc3151
Reference
PMID:21196257
  Authors
Overmeyer JH, Maltese WA
  Title
Death pathways triggered by activated Ras in cancer cells.
  Journal
Front Biosci (Landmark Ed) 16:1693-713 (2011)
DOI:10.2741/3814
Reference
PMID:16869784
  Authors
Rodriguez-Viciana P, Tetsu O, Oda K, Okada J, Rauen K, McCormick F
  Title
Cancer targets in the Ras pathway.
  Journal
Cold Spring Harb Symp Quant Biol 70:461-7 (2005)
DOI:10.1101/sqb.2005.70.044
Reference
PMID:14663478
  Authors
Cox AD, Der CJ
  Title
The dark side of Ras: regulation of apoptosis.
  Journal
Oncogene 22:8999-9006 (2003)
DOI:10.1038/sj.onc.1207111
Reference
PMID:18413813
  Authors
Braun BS, Shannon K
  Title
Targeting Ras in myeloid leukemias.
  Journal
Clin Cancer Res 14:2249-52 (2008)
DOI:10.1158/1078-0432.CCR-07-1005
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PMID:20420946
  Authors
Pino MS, Chung DC
  Title
The chromosomal instability pathway in colon cancer.
  Journal
Gastroenterology 138:2059-72 (2010)
DOI:10.1053/j.gastro.2009.12.065
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PMID:12217381
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Schrader JW, Schallhorn A, Grill B, Guo X
  Title
Activation of small GTPases of the Ras and Rho family by growth factors active on mast cells.
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Mol Immunol 38:1181-6 (2002)
DOI:10.1016/S0161-5890(02)00060-3
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PMID:22189424
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Ahearn IM, Haigis K, Bar-Sagi D, Philips MR
  Title
Regulating the regulator: post-translational modification of RAS.
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Nat Rev Mol Cell Biol 13:39-51 (2012)
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Ehrhardt GR, Korherr C, Wieler JS, Knaus M, Schrader JW
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A novel potential effector of M-Ras and p21 Ras negatively regulates p21 Ras-mediated gene induction and cell growth.
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Oncogene 20:188-97 (2001)
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Goldfinger LE, Ptak C, Jeffery ED, Shabanowitz J, Hunt DF, Ginsberg MH
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RLIP76 (RalBP1) is an R-Ras effector that mediates adhesion-dependent Rac activation and cell migration.
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J Cell Biol 174:877-88 (2006)
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PMID:23506953
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Kortum RL, Rouquette-Jazdanian AK, Samelson LE
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Ras and extracellular signal-regulated kinase signaling in thymocytes and T cells.
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Trends Immunol 34:259-68 (2013)
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Roberts DM, Anderson AL, Hidaka M, Swetenburg RL, Patterson C, Stanford WL, Bautch VL
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A vascular gene trap screen defines RasGRP3 as an angiogenesis-regulated gene required for the endothelial response to phorbol esters.
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Mol Cell Biol 24:10515-28 (2004)
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The Ras branch of small GTPases: Ras family members don't fall far from the tree.
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Curr Opin Cell Biol 12:157-65 (2000)
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The RasGrf family of mammalian guanine nucleotide exchange factors.
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Biochim Biophys Acta 1815:170-88 (2011)
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PMID:18437264
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Iwashita S, Song SY
  Title
RasGAPs: a crucial regulator of extracellular stimuli for homeostasis of cellular functions.
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Mol Biosyst 4:213-22 (2008)
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Ory S, Morrison DK
  Title
Signal transduction: implications for Ras-dependent ERK signaling.
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Curr Biol 14:R277-8 (2004)
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Reference
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  Authors
Matheny SA, White MA
  Title
Signaling threshold regulation by the Ras effector IMP.
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J Biol Chem 284:11007-11 (2009)
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Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
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Cell 141:1117-34 (2010)
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Skaper SD
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The neurotrophin family of neurotrophic factors: an overview.
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Methods Mol Biol 846:1-12 (2012)
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Apken LH, Oeckinghaus A
  Title
The RAL signaling network: Cancer and beyond.
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Int Rev Cell Mol Biol 361:21-105 (2021)
DOI:10.1016/bs.ircmb.2020.10.005
Related
pathway
tmu04010  MAPK signaling pathway
tmu04015  Rap1 signaling pathway
tmu04020  Calcium signaling pathway
tmu04144  Endocytosis
tmu04151  PI3K-Akt signaling pathway
tmu04660  T cell receptor signaling pathway
tmu04720  Long-term potentiation
tmu04810  Regulation of actin cytoskeleton
KO pathway
ko04014   
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