KEGG   PATHWAY: phyp04020
Entry
phyp04020                   Pathway                                
Name
Calcium signaling pathway - Pangasianodon hypophthalmus (striped catfish)
Description
Ca2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this external source of signal Ca2+ by activating various entry channels with widely different properties. The voltage-operated channels (VOCs) are found in excitable cells and generate the rapid Ca2+ fluxes that control fast cellular processes. There are many other Ca2+-entry channels, such as the receptor-operated channels (ROCs), for example the NMDA (N-methyl-D-aspartate) receptors (NMDARs) that respond to glutamate. There also are second-messenger-operated channels (SMOCs) and store-operated channels (SOCs).
The other principal source of Ca2+ for signalling is the internal stores that are located primarily in the endoplasmic/sarcoplasmic reticulum (ER/SR), in which inositol-1,4,5-trisphosphate receptors (IP3Rs) or ryanodine receptors (RYRs) regulate the release of Ca2+. The principal activator of these channels is Ca2+ itself and this process of Ca2+-induced Ca2+ release is central to the mechanism of Ca2+ signalling. Various second messengers or modulators also control the release of Ca2+. IP3, which is generated by pathways using different isoforms of phospholipase C (PLCbeta, delta, epsilon, gamma and zeta), regulates the IP3Rs. Cyclic ADP-ribose (cADPR) releases Ca2+ via RYRs. Nicotinic acid adenine dinucleotide phosphate (NAADP) may activate a distinct Ca2+ release mechanism on separate acidic Ca2+ stores. Ca2+ release via the NAADP-sensitive mechanism may also feedback onto either RYRs or IP3Rs. cADPR and NAADP are generated by CD38. This enzyme might be sensitive to the cellular metabolism, as ATP and NADH inhibit it.
The influx of Ca2+ from the environment or release from internal stores causes a very rapid and dramatic increase in cytoplasmic calcium concentration, which has been widely exploited for signal transduction. Some proteins, such as troponin C (TnC) involved in muscle contraction, directly bind to and sense Ca2+. However, in other cases Ca2+ is sensed through intermediate calcium sensors such as calmodulin (CALM).
Class
Environmental Information Processing; Signal transduction
Pathway map
phyp04020  Calcium signaling pathway
phyp04020

Other DBs
GO: 0019722
Organism
Pangasianodon hypophthalmus (striped catfish) [GN:phyp]
Gene
113525173  sodium/calcium exchanger 3-like [KO:K05849]
113524265  sodium/calcium exchanger 1-like isoform X1 [KO:K05849]
113525027  sodium/calcium exchanger 1-like [KO:K05849]
113531172  sodium/calcium exchanger 2-like [KO:K05849]
113540504  sodium/calcium exchanger 1-like [KO:K05849]
113541717  sodium/calcium exchanger 1-like [KO:K05849]
113544653  sodium/calcium exchanger 2-like isoform X1 [KO:K05849]
113529376  plasma membrane calcium-transporting ATPase 1-like [KO:K05850] [EC:7.2.2.10]
113531947  plasma membrane calcium-transporting ATPase 1-like [KO:K05850] [EC:7.2.2.10]
113534929  plasma membrane calcium-transporting ATPase 3-like isoform X1 [KO:K05850] [EC:7.2.2.10]
113537795  atp2b2; plasma membrane calcium-transporting ATPase 2 isoform X1 [KO:K05850] [EC:7.2.2.10]
113530469  atp2b3; plasma membrane calcium-transporting ATPase 3 isoform X1 [KO:K05850] [EC:7.2.2.10]
113539687  atp2b4; plasma membrane calcium-transporting ATPase 4 isoform X1 [KO:K05850] [EC:7.2.2.10]
113531191  muscarinic acetylcholine receptor M1-like [KO:K04129]
113529234  muscarinic acetylcholine receptor M3-like [KO:K04129]
113527089  chrm3; muscarinic acetylcholine receptor M3 [KO:K04131]
113544995  muscarinic acetylcholine receptor M3-like [KO:K04131]
113530104  muscarinic acetylcholine receptor M5-like [KO:K04133]
113531940  chrm5; muscarinic acetylcholine receptor M5 [KO:K04133]
113542994  adora2a; adenosine receptor A2a [KO:K04266]
113531619  adora2b; adenosine receptor A2b [KO:K04267]
113527186  adrb1; beta-1 adrenergic receptor isoform X1 [KO:K04141]
113541827  beta-2 adrenergic receptor-like [KO:K04142]
113529259  beta-2 adrenergic receptor-like [KO:K04142]
113533326  beta-1 adrenergic receptor-like [KO:K04143]
113541698  drd1; D(1A) dopamine receptor [KO:K04144]
113529569  D(1) dopamine receptor-like [KO:K04144]
113528514  drd5; D(1B) dopamine receptor [KO:K05840]
113547737  D(1) dopamine receptor-like [KO:K05840]
113524164  histamine H2 receptor-like [KO:K04150]
113529978  histamine H2 receptor-like isoform X1 [KO:K04150]
113528999  htr4; 5-hydroxytryptamine receptor 4 isoform X1 [KO:K04160]
113543199  5-hydroxytryptamine receptor 4-like [KO:K04160]
113540563  htr5a; 5-hydroxytryptamine receptor 5A [KO:K04161]
113543380  5-hydroxytryptamine receptor 5A-like [KO:K04161]
113530823  htr6; 5-hydroxytryptamine receptor 6 [KO:K04162]
113527283  htr7; 5-hydroxytryptamine receptor 7 [KO:K04163]
113536848  5-hydroxytryptamine receptor 7-like [KO:K04163]
113547738  5-hydroxytryptamine receptor 7-like [KO:K04163]
113545913  gnas; guanine nucleotide-binding protein G(s) subunit alpha [KO:K04632]
113533656  guanine nucleotide-binding protein G(s) subunit alpha-like [KO:K04632]
113533040  gnal; guanine nucleotide-binding protein G(olf) subunit alpha isoform X1 [KO:K04633]
113533810  guanine nucleotide-binding protein G(olf) subunit alpha-like [KO:K04633]
113545185  adenylate cyclase type 1-like [KO:K08041] [EC:4.6.1.1]
113547307  adcy1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
113543796  adenylate cyclase type 2-like [KO:K08042] [EC:4.6.1.1]
113534051  adenylate cyclase type 2-like [KO:K08042] [EC:4.6.1.1]
113526734  adcy3; adenylate cyclase type 3 isoform X1 [KO:K08043] [EC:4.6.1.1]
113544317  adenylate cyclase type 4-like isoform X1 [KO:K08044] [EC:4.6.1.1]
113540899  adcy7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
113532110  adenylate cyclase type 8-like [KO:K08048] [EC:4.6.1.1]
113543309  adcy8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
113547577  adenylate cyclase type 9-like [KO:K08049] [EC:4.6.1.1]
113531511  prkacb; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
113537420  cAMP-dependent protein kinase catalytic subunit alpha-like [KO:K04345] [EC:2.7.11.11]
113546254  cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
113526732  cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
113531870  pln; cardiac phospholamban [KO:K05852]
113534148  cardiac phospholamban-like [KO:K05852]
113544549  sln; sarcolipin [KO:K22642]
113535600  sarcoplasmic/endoplasmic reticulum calcium ATPase 2 isoform X1 [KO:K05853] [EC:7.2.2.10]
113539182  sarcoplasmic/endoplasmic reticulum calcium ATPase 2-like [KO:K05853] [EC:7.2.2.10]
113531394  atp2a3; sarcoplasmic/endoplasmic reticulum calcium ATPase 3 [KO:K05853] [EC:7.2.2.10]
113534988  sarcoplasmic/endoplasmic reticulum calcium ATPase 2-like [KO:K05853] [EC:7.2.2.10]
113547511  sarcoplasmic/endoplasmic reticulum calcium ATPase 1 [KO:K05853] [EC:7.2.2.10]
113528132  sarcoplasmic/endoplasmic reticulum calcium ATPase 1-like isoform X1 [KO:K05853] [EC:7.2.2.10]
113527266  sarcoplasmic reticulum histidine-rich calcium-binding protein-like [KO:K23450]
113541520  stim1; stromal interaction molecule 1 isoform X1 [KO:K16059]
113539174  stromal interaction molecule 1-like isoform X1 [KO:K16059]
113540623  stim2; stromal interaction molecule 2 [KO:K18196]
113547674  uncharacterized protein LOC113547674 [KO:K18196]
113546074  calcium release-activated calcium channel protein 1-like [KO:K16056]
113543962  calcium release-activated calcium channel protein 1 [KO:K16056]
113531613  orai2; protein orai-2 [KO:K16057]
113544629  voltage-dependent L-type calcium channel subunit alpha-1D-like [KO:K04850]
113533266  cacna1d; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
113539515  voltage-dependent L-type calcium channel subunit alpha-1D-like isoform X1 [KO:K04851]
113528653  voltage-dependent L-type calcium channel subunit alpha-1F-like [KO:K04853]
113533319  voltage-dependent L-type calcium channel subunit alpha-1D-like isoform X1 [KO:K04853]
113526802  cacna1s; voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
113523781  cacna1a; voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform X1 [KO:K04344]
113525358  voltage-dependent P/Q-type calcium channel subunit alpha-1A-like [KO:K04344]
113535492  voltage-dependent N-type calcium channel subunit alpha-1B-like [KO:K04849]
113536882  voltage-dependent N-type calcium channel subunit alpha-1B-like isoform X1 [KO:K04849]
113535232  voltage-dependent R-type calcium channel subunit alpha-1E-like [KO:K04852]
113526546  voltage-dependent R-type calcium channel subunit alpha-1E-like isoform X1 [KO:K04852]
113527370  cacna1g; voltage-dependent T-type calcium channel subunit alpha-1G isoform X1 [KO:K04854]
113535966  cacna1h; voltage-dependent T-type calcium channel subunit alpha-1H isoform X1 [KO:K04855]
113523774  voltage-dependent T-type calcium channel subunit alpha-1I-like [KO:K04856]
113538184  cacna1i; voltage-dependent T-type calcium channel subunit alpha-1I [KO:K04856]
113529634  neuronal acetylcholine receptor subunit alpha-7-like isoform X1 [KO:K04809]
113547351  neuronal acetylcholine receptor subunit alpha-7-like [KO:K04809]
113534928  neuronal acetylcholine receptor subunit alpha-7-like [KO:K04809]
113536759  neuronal acetylcholine receptor subunit alpha-7-like [KO:K04809]
113535563  glutamate receptor ionotropic, NMDA 1-like isoform X1 [KO:K05208]
113536981  grin1; glutamate receptor ionotropic, NMDA 1 isoform X1 [KO:K05208]
113535803  glutamate receptor ionotropic, NMDA 2A-like [KO:K05209]
113546901  grin2a; glutamate receptor ionotropic, NMDA 2A [KO:K05209]
113537658  glutamate receptor ionotropic, NMDA 2B-like isoform X1 [KO:K05210]
113524086  glutamate receptor ionotropic, NMDA 2B-like [KO:K05210]
113527776  glutamate receptor ionotropic, NMDA 2C-like [KO:K05211]
113528498  glutamate receptor ionotropic, NMDA 2C-like [KO:K05211]
113535113  glutamate receptor ionotropic, NMDA 2D-like isoform X1 [KO:K05212]
113542324  glutamate receptor ionotropic, NMDA 2D-like [KO:K05212]
113544118  grin3a; glutamate receptor ionotropic, NMDA 3A [KO:K05213]
113531650  grin3b; glutamate receptor ionotropic, NMDA 3B [KO:K05214]
113524389  glutamate receptor ionotropic, NMDA 3A-like [KO:K05214]
113531054  p2rx1; P2X purinoceptor 1 isoform X1 [KO:K05215]
113537142  p2rx2; P2X purinoceptor 2 [KO:K05216]
113539388  p2rx3; P2X purinoceptor 3 [KO:K05217]
113542711  P2X purinoceptor 3-like [KO:K05217]
113535677  p2rx4; P2X purinoceptor 4 isoform X1 [KO:K05218]
113532909  P2X purinoceptor 5-like [KO:K05219]
113531642  P2X purinoceptor 5-like isoform X1 [KO:K05219]
113523728  ryanodine receptor 1-like [KO:K04961]
113526686  LOW QUALITY PROTEIN: ryanodine receptor 1-like [KO:K04961]
113544964  ryanodine receptor 2-like [KO:K04962]
113527372  ryr2; ryanodine receptor 2 isoform X1 [KO:K04962]
113532032  ryr3; ryanodine receptor 3 isoform X1 [KO:K04963]
113530100  ryanodine receptor 3-like isoform X1 [KO:K04963]
113531929  trdn; triadin [KO:K23449]
113544409  calsequestrin-1-like isoform X1 [KO:K23468]
113537641  calsequestrin-2-like [KO:K23445]
113547439  calsequestrin-2-like [KO:K23445]
113540138  asph; aspartyl/asparaginyl beta-hydroxylase isoform X1 [KO:K00476] [EC:1.14.11.16]
113532864  cysteinyl leukotriene receptor 2-like [KO:K04322]
113542753  cysltr1; cysteinyl leukotriene receptor 1 [KO:K04322]
113543359  cysteinyl leukotriene receptor 2-like [KO:K04322]
113539297  cysteinyl leukotriene receptor 2-like [KO:K04323]
113541556  cysteinyl leukotriene receptor 2-like [KO:K04323]
113528685  muscarinic acetylcholine receptor M2-like [KO:K04130]
113529780  chrm2; muscarinic acetylcholine receptor M2 [KO:K04130]
113524470  alpha-1A adrenergic receptor-like [KO:K04135]
113544181  alpha-1A adrenergic receptor-like [KO:K04135]
113547160  alpha-1A adrenergic receptor-like [KO:K04136]
113541500  adra1b; alpha-1B adrenergic receptor [KO:K04136]
113545706  adra1d; alpha-1D adrenergic receptor [KO:K04137]
113545434  agtr1; type-1 angiotensin II receptor [KO:K04166]
113542318  endothelin receptor type B-like [KO:K04197]
113530286  endothelin receptor type B-like [KO:K04197]
113542803  endothelin receptor type B-like [KO:K04198]
113537284  endothelin receptor type B-like [KO:K04198]
113537012  f2r; proteinase-activated receptor 1 [KO:K03914]
113529136  metabotropic glutamate receptor 1-like isoform X1 [KO:K04603]
113538963  metabotropic glutamate receptor 1-like isoform X1 [KO:K04603]
113543677  grm5; metabotropic glutamate receptor 5 [KO:K04604]
113544619  metabotropic glutamate receptor 5-like [KO:K04604]
113547449  grpr; gastrin-releasing peptide receptor [KO:K04169]
113538079  hrh1; histamine H1 receptor [KO:K04149]
113524671  5-hydroxytryptamine receptor 2A-like [KO:K04157]
113540633  htr2c; 5-hydroxytryptamine receptor 2C [KO:K04157]
113538455  5-hydroxytryptamine receptor 2A-like [KO:K04157]
113536532  htr2b; 5-hydroxytryptamine receptor 2B [KO:K04157]
113541391  5-hydroxytryptamine receptor 2C-like [KO:K04157]
113542040  lutropin-choriogonadotropic hormone receptor-like [KO:K04248]
113545799  lutropin-choriogonadotropic hormone receptor-like [KO:K04248]
113530795  ntsr1; neurotensin receptor type 1 [KO:K04211]
113544269  pyrokinin-1 receptor-like [KO:K04211]
113533827  isotocin receptor-like [KO:K04229]
113533905  isotocin receptor-like [KO:K04229]
113525812  isotocin receptor-like [KO:K04229]
113531785  arg8-vasotocin receptor-like [KO:K04226]
113529550  arg8-vasotocin receptor-like [KO:K04226]
113544224  leukotriene B4 receptor 1-like [KO:K04297]
113533766  platelet-activating factor receptor-like [KO:K04279]
113528579  prostaglandin E2 receptor EP1 subtype-like [KO:K04258]
113546176  prostaglandin E2 receptor EP1 subtype-like [KO:K04258]
113545956  ptger3; prostaglandin E2 receptor EP3 subtype [KO:K04260]
113530658  ptgfr; prostaglandin F2-alpha receptor [KO:K04262]
113538917  B1 bradykinin receptor-like [KO:K03915]
113524830  B2 bradykinin receptor-like [KO:K03916]
113538846  B2 bradykinin receptor-like [KO:K03916]
113538847  B2 bradykinin receptor-like [KO:K03916]
113542384  substance-P receptor-like [KO:K04222]
113543661  tacr2; substance-K receptor isoform X1 [KO:K04223]
113524539  neuromedin-K receptor-like isoform X1 [KO:K04224]
113545720  tacr3; neuromedin-K receptor [KO:K04224]
113525310  neuromedin-K receptor-like [KO:K04224]
113546124  tbxa2r; thromboxane A2 receptor isoform X1 [KO:K04264]
113536187  thyrotropin-releasing hormone receptor-like [KO:K04282]
113526405  trhr; thyrotropin-releasing hormone receptor [KO:K04282]
113534697  thyrotropin-releasing hormone receptor-like [KO:K04282]
113532982  thyrotropin-releasing hormone receptor-like [KO:K04282]
113539956  cckar; cholecystokinin receptor type A [KO:K04194]
113526102  cholecystokinin receptor-like [KO:K04194]
113537562  cholecystokinin receptor-like [KO:K04194]
113526054  cxcr4; C-X-C chemokine receptor type 4 [KO:K04189]
113538220  C-X-C chemokine receptor type 4-B-like [KO:K04189]
113531284  guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
113531146  guanine nucleotide-binding protein G(q) subunit alpha-like [KO:K04634]
113533313  guanine nucleotide-binding protein G(q) subunit alpha-like [KO:K04635]
113527868  guanine nucleotide-binding protein subunit alpha-11 [KO:K04635]
113533524  guanine nucleotide-binding protein subunit alpha-14-like [KO:K04636]
113532093  guanine nucleotide-binding protein subunit alpha-11-like [KO:K04637]
113547167  pro-epidermal growth factor-like [KO:K04357]
113533017  protransforming growth factor alpha-like [KO:K08774]
113528535  uncharacterized protein LOC113528535 isoform X1 [KO:K04359]
113547595  platelet-derived growth factor subunit A-like isoform X1 [KO:K04359]
113547643  histidine-rich glycoprotein-like [KO:K17386]
113547158  pdgfc; platelet-derived growth factor C [KO:K05450]
113544462  pdgfd; platelet-derived growth factor D [KO:K05450]
113530070  putative fibroblast growth factor 1 [KO:K18496]
113541732  fgf1; fibroblast growth factor 1 [KO:K18496]
113528646  fibroblast growth factor 2-like [KO:K18497]
113546619  fibroblast growth factor 6-like [KO:K04358]
113528170  fibroblast growth factor 22-like [KO:K04358]
113537717  fibroblast growth factor 8b-like [KO:K04358]
113532184  fgf6; fibroblast growth factor 6 [KO:K04358]
113546043  fibroblast growth factor 17-like [KO:K04358]
113529928  fibroblast growth factor 18-like [KO:K04358]
113536652  fgf4; fibroblast growth factor 4 [KO:K04358]
113536661  fgf3; fibroblast growth factor 3 [KO:K04358]
113528740  fibroblast growth factor 18-like [KO:K04358]
113526095  fibroblast growth factor 4A-like [KO:K04358]
113542699  fgf16; fibroblast growth factor 16 [KO:K04358]
113529246  fibroblast growth factor 20-like [KO:K04358]
113533156  fibroblast growth factor 22-like [KO:K04358]
113537199  fgf5; fibroblast growth factor 5 [KO:K04358]
113538405  fgf8; fibroblast growth factor 8 [KO:K04358]
113526449  fgf7; fibroblast growth factor 7 [KO:K04358]
113543237  fgf10; fibroblast growth factor 10 [KO:K04358]
113544944  fibroblast growth factor 18-like [KO:K04358]
113547386  fgf20; fibroblast growth factor 20 [KO:K04358]
113536687  fgf19; fibroblast growth factor 19 [KO:K22603]
113546510  fibroblast growth factor 19-like [KO:K22429]
113532387  fgf23; fibroblast growth factor 23 [KO:K22428]
113546666  uncharacterized protein LOC113546666 [KO:K22428]
113525271  vascular endothelial growth factor A-A-like [KO:K05448]
113531871  vegfa; vascular endothelial growth factor A isoform X1 [KO:K05448]
113541406  vascular endothelial growth factor A-A-like [KO:K05448]
113538396  vegfc; vascular endothelial growth factor C [KO:K05449]
113547457  vegfd; vascular endothelial growth factor D isoform X1 [KO:K05449]
113533487  ngf; beta-nerve growth factor [KO:K02582]
113545633  neurotrophin-7-like [KO:K02582]
113534821  hgf; hepatocyte growth factor [KO:K05460]
113537768  mst1; hepatocyte growth factor-like protein isoform X1 [KO:K23441]
113544749  gdnf; glial cell line-derived neurotrophic factor [KO:K05452]
113546391  egfr; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
113547490  erbb2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
113527462  erbb3; receptor tyrosine-protein kinase erbB-3 isoform X1 [KO:K05084] [EC:2.7.10.1]
113530351  receptor tyrosine-protein kinase erbB-3-like [KO:K05084] [EC:2.7.10.1]
113535598  receptor tyrosine-protein kinase erbB-4-like isoform X1 [KO:K05085] [EC:2.7.10.1]
113535765  receptor tyrosine-protein kinase erbB-4-like [KO:K05085] [EC:2.7.10.1]
113525375  erbb4; receptor tyrosine-protein kinase erbB-4 [KO:K05085] [EC:2.7.10.1]
113546841  pdgfra; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
113529620  pdgfrb; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
113533198  fibroblast growth factor receptor 1-A isoform X1 [KO:K04362] [EC:2.7.10.1]
113533113  fibroblast growth factor receptor 1-A-like [KO:K04362] [EC:2.7.10.1]
113542009  fgfr2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
113539741  fgfr3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
113541573  fgfr4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
113541212  flt1; vascular endothelial growth factor receptor 1 isoform X1 [KO:K05096] [EC:2.7.10.1]
113528886  vascular endothelial growth factor receptor kdr-like [KO:K05096] [EC:2.7.10.1]
113542868  flt4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
113546829  kdr; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
113532627  ntrk1; high affinity nerve growth factor receptor isoform X1 [KO:K03176] [EC:2.7.10.1]
113531639  BDNF/NT-3 growth factors receptor-like [KO:K04360] [EC:2.7.10.1]
113533488  ntrk2; BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
113546626  NT-3 growth factor receptor-like [KO:K05101] [EC:2.7.10.1]
113536380  ntrk3; NT-3 growth factor receptor [KO:K05101] [EC:2.7.10.1]
113546663  met; hepatocyte growth factor receptor isoform X1 [KO:K05099] [EC:2.7.10.1]
113539569  mst1r; macrophage-stimulating protein receptor [KO:K05100] [EC:2.7.10.1]
113526157  macrophage-stimulating protein receptor-like [KO:K05100] [EC:2.7.10.1]
113537802  ret; proto-oncogene tyrosine-protein kinase receptor Ret isoform X1 [KO:K05126] [EC:2.7.10.1]
113546930  immunoglobulin gamma-1 heavy chain-like [KO:K06856]
113524284  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4-like [KO:K05857] [EC:3.1.4.11]
113528422  plcd3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 [KO:K05857] [EC:3.1.4.11]
113527763  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3-A-like isoform X1 [KO:K05857] [EC:3.1.4.11]
113541158  plcd1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 isoform X1 [KO:K05857] [EC:3.1.4.11]
113543147  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1-like isoform X1 [KO:K05857] [EC:3.1.4.11]
113525803  LOW QUALITY PROTEIN: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4-like [KO:K05857] [EC:3.1.4.11]
113545235  plcb4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
113545247  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1-like isoform X1 [KO:K05858] [EC:3.1.4.11]
113540074  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3-like isoform X1 [KO:K05858] [EC:3.1.4.11]
113538843  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4-like [KO:K05858] [EC:3.1.4.11]
113538598  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2-like [KO:K05858] [EC:3.1.4.11]
113538670  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1-like [KO:K05858] [EC:3.1.4.11]
113545570  plcg1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 [KO:K01116] [EC:3.1.4.11]
113534527  plcg2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
113527060  plce1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X1 [KO:K05860] [EC:3.1.4.11]
113539752  itpr1; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
113545832  LOW QUALITY PROTEIN: inositol 1,4,5-trisphosphate receptor type 1-like [KO:K04958]
113534384  itpr2; inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
113526579  itpr3; inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
113532851  ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1-like [KO:K01242] [EC:3.2.2.6 2.4.99.20]
113546708  ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1-like [KO:K01242] [EC:3.2.2.6 2.4.99.20]
113536479  tpcn2; two pore calcium channel protein 2 isoform X1 [KO:K14077]
113537656  mcoln1; mucolipin-1 [KO:K04992]
113534676  mucolipin-1-like [KO:K04992]
113536545  mucolipin-2-like isoform X1 [KO:K04993]
113530809  mcoln3; mucolipin-3 isoform X1 [KO:K04994]
113534020  sphingosine kinase 2-like [KO:K04718] [EC:2.7.1.91]
113534313  sphingosine kinase 1-like [KO:K04718] [EC:2.7.1.91]
113538397  sphk1; sphingosine kinase 1 [KO:K04718] [EC:2.7.1.91]
113542075  mcu; calcium uniporter protein, mitochondrial isoform X1 [KO:K20858]
113535684  vdac1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
113543440  vdac2; voltage-dependent anion-selective channel protein 2 [KO:K15040]
113533574  vdac3; voltage-dependent anion-selective channel protein 3 isoform X1 [KO:K15041]
113544819  voltage-dependent anion-selective channel protein 2-like [KO:K15041]
113547316  slc25a4; ADP/ATP translocase 1 [KO:K05863]
113546310  ADP/ATP translocase 1 [KO:K05863]
113529009  slc25a5; ADP/ATP translocase 2 [KO:K05863]
113531460  ADP/ATP translocase 1-like [KO:K05863]
113538258  ADP/ATP translocase 3-like isoform X1 [KO:K05863]
113524875  peptidyl-prolyl cis-trans isomerase A-like [KO:K09565] [EC:5.2.1.8]
113546041  peptidyl-prolyl cis-trans isomerase-like [KO:K09565] [EC:5.2.1.8]
113543545  ppif; peptidyl-prolyl cis-trans isomerase F, mitochondrial [KO:K09565] [EC:5.2.1.8]
113538013  troponin C, slow skeletal and cardiac muscles [KO:K05865]
113530766  troponin C, slow skeletal and cardiac muscles-like [KO:K05865]
113530767  troponin C, skeletal muscle [KO:K12042]
113530269  troponin C, skeletal muscle-like [KO:K12042]
113539215  calm3; calmodulin-3 [KO:K02183]
113525533  calmodulin-like [KO:K02183]
113524770  calmodulin [KO:K02183]
113540948  calml4; calmodulin-like protein 4 [KO:K02183]
113541571  calmodulin [KO:K02183]
113527455  calm2; calmodulin-2 [KO:K02183]
113535004  calml6; calmodulin-like protein 6 [KO:K02183]
113539735  calmodulin [KO:K02183]
113527058  phkg2; phosphorylase b kinase gamma catalytic chain, liver/testis isoform [KO:K00871] [EC:2.7.11.19]
113541799  phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform-like [KO:K00871] [EC:2.7.11.19]
113543328  phkg1; phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform [KO:K00871] [EC:2.7.11.19]
113527793  phka2; phosphorylase b kinase regulatory subunit alpha, liver isoform isoform X1 [KO:K07190]
113540386  phka1; phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform isoform X1 [KO:K07190]
113540850  phkb; phosphorylase b kinase regulatory subunit beta [KO:K07190]
113533962  myosin light chain kinase, smooth muscle-like isoform X1 [KO:K00907] [EC:2.7.11.18]
113538345  myosin light chain kinase, smooth muscle-like isoform X1 [KO:K00907] [EC:2.7.11.18]
113545533  myosin light chain kinase 2, skeletal/cardiac muscle-like isoform X1 [KO:K00907] [EC:2.7.11.18]
113525255  myosin light chain kinase, smooth muscle-like isoform X1 [KO:K00907] [EC:2.7.11.18]
113540796  mylk3; myosin light chain kinase 3 isoform X1 [KO:K00907] [EC:2.7.11.18]
113545325  mylk4; myosin light chain kinase family member 4 isoform X1 [KO:K00907] [EC:2.7.11.18]
113528426  myosin light chain kinase, smooth muscle-like [KO:K00907] [EC:2.7.11.18]
113547292  myosin light chain kinase 2, skeletal/cardiac muscle-like isoform X1 [KO:K00907] [EC:2.7.11.18]
113529941  calcium/calmodulin-dependent protein kinase type 1D-like [KO:K08794] [EC:2.7.11.17]
113531217  calcium/calmodulin-dependent protein kinase type 1-like [KO:K08794] [EC:2.7.11.17]
113539466  calcium/calmodulin-dependent protein kinase type 1-like [KO:K08794] [EC:2.7.11.17]
113530721  calcium/calmodulin-dependent protein kinase type 1D-like isoform X1 [KO:K08794] [EC:2.7.11.17]
113531867  calcium/calmodulin-dependent protein kinase type 1D-like [KO:K08794] [EC:2.7.11.17]
113525468  calcium/calmodulin-dependent protein kinase type II delta 2 chain-like isoform X1 [KO:K04515] [EC:2.7.11.17]
113524597  calcium/calmodulin-dependent protein kinase type II subunit alpha [KO:K04515] [EC:2.7.11.17]
113540678  calcium/calmodulin-dependent protein kinase type II delta 1 chain isoform X1 [KO:K04515] [EC:2.7.11.17]
113527509  calcium/calmodulin-dependent protein kinase type II delta chain-like isoform X1 [KO:K04515] [EC:2.7.11.17]
113536972  calcium/calmodulin-dependent protein kinase type II subunit beta-like isoform X1 [KO:K04515] [EC:2.7.11.17]
113543004  camk2g; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
113544821  camk2b; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
113531350  camk4; calcium/calmodulin-dependent protein kinase type IV [KO:K05869] [EC:2.7.11.17]
113546396  calcium/calmodulin-dependent protein kinase type IV-like [KO:K05869] [EC:2.7.11.17]
113540494  ppp3ca; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
113541447  serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform-like isoform X1 [KO:K04348] [EC:3.1.3.16]
113542615  serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform-like isoform X1 [KO:K04348] [EC:3.1.3.16]
113544065  serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform-like isoform X1 [KO:K04348] [EC:3.1.3.16]
113530088  serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform-like isoform X1 [KO:K04348] [EC:3.1.3.16]
113537343  calcineurin subunit B type 1 [KO:K06268]
113541892  ppp3r1; calcineurin subunit B type 1 [KO:K06268]
113539573  tfeb; transcription factor EB isoform X1 [KO:K15590]
113536200  nfatc1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
113543208  nuclear factor of activated T-cells, cytoplasmic 1-like isoform X1 [KO:K04446]
113530807  nfatc2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332]
113530316  nuclear factor of activated T-cells, cytoplasmic 2-like isoform X1 [KO:K17332]
113529871  nuclear factor of activated T-cells, cytoplasmic 3-like isoform X1 [KO:K17333]
113540945  nfatc3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
113539815  nfatc4; nuclear factor of activated T-cells, cytoplasmic 4 [KO:K17334]
113537215  nos1; nitric oxide synthase, brain [KO:K13240] [EC:1.14.13.39]
113539231  nitric oxide synthase, inducible-like [KO:K13241] [EC:1.14.13.39]
113539397  nitric oxide synthase, inducible-like [KO:K13241] [EC:1.14.13.39]
113526298  pde1a; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform X1 [KO:K13755] [EC:3.1.4.17]
113546381  calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A-like isoform X1 [KO:K13755] [EC:3.1.4.17]
113524444  calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B-like [KO:K13755] [EC:3.1.4.17]
113533885  calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A-like isoform X1 [KO:K13755] [EC:3.1.4.17]
113545212  protein-tyrosine kinase 2-beta-like isoform X1 [KO:K05871] [EC:2.7.10.2]
113538681  ptk2b; protein-tyrosine kinase 2-beta isoform X1 [KO:K05871] [EC:2.7.10.2]
113528895  inositol-trisphosphate 3-kinase B-like [KO:K00911] [EC:2.7.1.127]
113538774  itpka; inositol-trisphosphate 3-kinase A isoform X1 [KO:K00911] [EC:2.7.1.127]
113534579  itpkc; inositol-trisphosphate 3-kinase C [KO:K00911] [EC:2.7.1.127]
113543400  inositol-trisphosphate 3-kinase C-like [KO:K00911] [EC:2.7.1.127]
113527932  protein kinase C alpha type-like [KO:K02677] [EC:2.7.11.13]
113538454  prkca; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
113535689  protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
113528126  protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
113542453  protein kinase C gamma type-like isoform X1 [KO:K19663] [EC:2.7.11.13]
Compound
C00002  ATP
C00004  NADH
C00076  Calcium cation
C00165  Diacylglycerol
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01330  Sodium cation
C06124  Sphingosine 1-phosphate
C11556  1-Phosphatidyl-1D-myo-inositol 3,5-bisphosphate
C13050  Cyclic ADP-ribose
C13051  Nicotinic acid adenine dinucleotide phosphate
Reference
PMID:12838335
  Authors
Berridge MJ, Bootman MD, Roderick HL.
  Title
Calcium signalling: dynamics, homeostasis and remodelling.
  Journal
Nat Rev Mol Cell Biol 4:517-29 (2003)
DOI:10.1038/nrm1155
Reference
PMID:11413485
  Authors
Berridge MJ, Lipp P, Bootman MD.
  Title
The versatility and universality of calcium signalling.
  Journal
Nat Rev Mol Cell Biol 1:11-21 (2000)
DOI:10.1038/35036035
Reference
PMID:15111104
  Authors
Wang MC, Dolphin A, Kitmitto A.
  Title
L-type voltage-gated calcium channels: understanding function through structure.
  Journal
FEBS Lett 564:245-50 (2004)
DOI:10.1016/S0014-5793(04)00253-4
Reference
PMID:11299192
  Authors
Ferrier GR, Howlett SE.
  Title
Cardiac excitation-contraction coupling: role of membrane potential in regulation of contraction.
  Journal
Am J Physiol Heart Circ Physiol 280:H1928-44 (2001)
DOI:10.1152/ajpheart.2001.280.5.H1928
Reference
PMID:11698232
  Authors
Keef KD, Hume JR, Zhong J.
  Title
Regulation of cardiac and smooth muscle Ca(2+) channels (Ca(V)1.2a,b) by protein kinases.
  Journal
Am J Physiol Cell Physiol 281:C1743-56 (2001)
DOI:10.1152/ajpcell.2001.281.6.C1743
Reference
PMID:8125957
  Authors
Hell JW, Appleyard SM, Yokoyama CT, Warner C, Catterall WA.
  Title
Differential phosphorylation of two size forms of the N-type calcium channel alpha 1 subunit which have different COOH termini.
  Journal
J Biol Chem 269:7390-6 (1994)
Reference
PMID:15000521
  Authors
Yunker AM.
  Title
Modulation and pharmacology of low voltage-activated ("T-Type") calcium channels.
  Journal
J Bioenerg Biomembr 35:577-98 (2003)
DOI:10.1023/B:JOBB.0000008025.65675.37
Reference
PMID:9149541
  Authors
Yakel JL.
  Title
Calcineurin regulation of synaptic function: from ion channels to transmitter release and gene transcription.
  Journal
Trends Pharmacol Sci 18:124-34 (1997)
DOI:10.1016/S0165-6147(97)01046-8
Reference
PMID:10997573
  Authors
Fukunaga K, Miyamoto E.
  Title
A working model of CaM kinase II activity in hippocampal long-term potentiation and memory.
  Journal
Neurosci Res 38:3-17 (2000)
DOI:10.1016/S0168-0102(00)00139-5
Reference
PMID:9235901
  Authors
Della Rocca GJ, van Biesen T, Daaka Y, Luttrell DK, Luttrell LM, Lefkowitz RJ.
  Title
Ras-dependent mitogen-activated protein kinase activation by G protein-coupled receptors. Convergence of Gi- and Gq-mediated pathways on calcium/calmodulin, Pyk2, and Src kinase.
  Journal
J Biol Chem 272:19125-32 (1997)
DOI:10.1074/jbc.272.31.19125
Reference
PMID:7861177
  Authors
Furuichi T, Mikoshiba K.
  Title
Inositol 1, 4, 5-trisphosphate receptor-mediated Ca2+ signaling in the brain.
  Journal
J Neurochem 64:953-60 (1995)
DOI:10.1046/j.1471-4159.1995.64030953.x
Reference
PMID:14572802
  Authors
Bruce JI, Straub SV, Yule DI.
  Title
Crosstalk between cAMP and Ca2+ signaling in non-excitable cells.
  Journal
Cell Calcium 34:431-44 (2003)
DOI:10.1016/S0143-4160(03)00150-7
Reference
PMID:10331643
  Authors
Lee HC, Munshi C, Graeff R.
  Title
Structures and activities of cyclic ADP-ribose, NAADP and their metabolic enzymes.
  Journal
Mol Cell Biochem 193:89-98 (1999)
DOI:10.1007/978-1-4419-8740-2_13
Reference
PMID:11080247
  Authors
Crompton M.
  Title
Mitochondrial intermembrane junctional complexes and their role in cell death.
  Journal
J Physiol 529 Pt 1:11-21 (2000)
DOI:10.1111/j.1469-7793.2000.00011.x
Reference
PMID:10508738
  Authors
Grewal SS, York RD, Stork PJ.
  Title
Extracellular-signal-regulated kinase signalling in neurons.
  Journal
Curr Opin Neurobiol 9:544-53 (1999)
DOI:10.1016/S0959-4388(99)00010-0
Reference
PMID:12972622
  Authors
Trushin SA, Pennington KN, Carmona EM, Asin S, Savoy DN, Billadeau DD, Paya CV.
  Title
Protein kinase Calpha (PKCalpha) acts upstream of PKCtheta to activate IkappaB kinase and NF-kappaB in T lymphocytes.
  Journal
Mol Cell Biol 23:7068-81 (2003)
DOI:10.1128/MCB.23.19.7068-7081.2003
Reference
PMID:14517314
  Authors
Hutchins JR, Dikovskaya D, Clarke PR.
  Title
Regulation of Cdc2/cyclin B activation in Xenopus egg extracts via inhibitory phosphorylation of Cdc25C phosphatase by Ca(2+)/calmodulin-dependent protein [corrected] kinase II.
  Journal
Mol Biol Cell 14:4003-14 (2003)
DOI:10.1091/mbc.E03-02-0061
Reference
PMID:21338471
  Authors
Tornquist K
  Title
Sphingosine 1-phosphate, sphingosine kinase and autocrine calcium signalling in thyroid cells.
  Journal
Acta Physiol (Oxf) 204:151-7 (2012)
DOI:10.1111/j.1748-1716.2011.02265.x
Reference
PMID:22129055
  Authors
Feske S
  Title
Immunodeficiency due to defects in store-operated calcium entry.
  Journal
Ann N Y Acad Sci 1238:74-90 (2011)
DOI:10.1111/j.1749-6632.2011.06240.x
Reference
PMID:22002090
  Authors
Giachini FR, Lima VV, Hannan JL, Carneiro FS, Webb RC, Tostes RC
  Title
STIM1/Orai1-mediated store-operated Ca2+ entry: the tip of the iceberg.
  Journal
Braz J Med Biol Res 44:1080-7 (2011)
DOI:10.1590/S0100-879X2011007500133
Reference
PMID:19172794
  Authors
Baba Y, Kurosaki T
  Title
[Regulation of store-operated calcium entry by STIM1].
  Journal
Seikagaku 80:1123-8 (2008)
Reference
PMID:19475418
  Authors
Galione A, Evans AM, Ma J, Parrington J, Arredouani A, Cheng X, Zhu MX
  Title
The acid test: the discovery of two-pore channels (TPCs) as NAADP-gated endolysosomal Ca(2+) release channels.
  Journal
Pflugers Arch 458:869-76 (2009)
DOI:10.1007/s00424-009-0682-y
Reference
PMID:19434403
  Authors
Beard NA, Wei L, Dulhunty AF
  Title
Ca(2+) signaling in striated muscle: the elusive roles of triadin, junctin, and calsequestrin.
  Journal
Eur Biophys J 39:27-36 (2009)
DOI:10.1007/s00249-009-0449-6
Reference
PMID:26228554
  Authors
Marty I
  Title
Triadin regulation of the ryanodine receptor complex.
  Journal
J Physiol 593:3261-6 (2015)
DOI:10.1113/jphysiol.2014.281147
Reference
PMID:20807542
  Authors
Arvanitis DA, Vafiadaki E, Sanoudou D, Kranias EG
  Title
Histidine-rich calcium binding protein: the new regulator of sarcoplasmic reticulum calcium cycling.
  Journal
J Mol Cell Cardiol 50:43-9 (2011)
DOI:10.1016/j.yjmcc.2010.08.021
Related
pathway
phyp04010  MAPK signaling pathway
phyp04070  Phosphatidylinositol signaling system
phyp04210  Apoptosis
KO pathway
ko04020   
LinkDB

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