Entry Name Tuberculosis - Peromyscus leucopus (white-footed mouse)
Description Tuberculosis, or TB, is an infectious disease caused by Mycobacterium tuberculosis. One third of the world's population is thought to be infected with TB. About 90% of those infected result in latent infections, and about 10% of latent infections develop active diseases when their immune system is impaired due to the age, other diseases such as AIDS or exposure to immunosuppressive drugs. TB is transmitted through the air and primarily attacks the lungs, then it can spread by the circulatory system to other parts of body. Once TB bacilli have entered the host by the respiratory route and infected macrophages in the lungs, they interfere with phagosomal maturation, antigen presentation, apoptosis and host immune system to establish persistent or latent infection.
Class Human Diseases; Infectious disease: bacterialBRITE hierarchy
Pathway map Disease Organism Peromyscus leucopus (white-footed mouse) [GN:
pleu ]
Gene 114680676 Bad; bcl2-associated agonist of cell death isoform X1 [KO:K02158 ]
114680749 Atp6v0c; V-type proton ATPase 16 kDa proteolipid subunit [KO:K02155 ]
114681076 Tradd; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171 ]
114682227 Camk2d; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X1 [KO:K04515 ] [EC:2.7.11.17 ]
114682503 Myd88; myeloid differentiation primary response protein MyD88 [KO:K04729 ]
114682831 Atp6v0a1; V-type proton ATPase 116 kDa subunit a1 isoform X1 [KO:K02154 ]
114683255 Ppp3ca; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348 ] [EC:3.1.3.16 ]
114685425 Fcer1g; high affinity immunoglobulin epsilon receptor subunit gamma [KO:K07983 ]
114685957 Malt1; mucosa-associated lymphoid tissue lymphoma translocation protein 1 isoform X1 [KO:K07369 ] [EC:3.4.22.-]
114687533 Cr1l; complement component receptor 1-like protein isoform X1 [KO:K04011 ]
114688007 Clec4e; C-type lectin domain family 4 member E isoform X1 [KO:K10059 ]
114689890 Fcgr2b; low affinity immunoglobulin gamma Fc region receptor II-b isoform X3 [KO:K12560 ]
114691150 Arhgef12; rho guanine nucleotide exchange factor 12 isoform X1 [KO:K07532 ]
114691198 Il10ra; interleukin-10 receptor subunit alpha isoform X1 [KO:K05134 ]
114692817 Card9; caspase recruitment domain-containing protein 9 isoform X1 [KO:K12794 ]
114693978 Camk2b; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X7 [KO:K04515 ] [EC:2.7.11.17 ]
114698210 Tgfb2; transforming growth factor beta-2 proprotein isoform X1 [KO:K13376 ]
114698768 Ppp3cc; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform [KO:K04348 ] [EC:3.1.3.16 ]
114700198 Ppp3cb; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348 ] [EC:3.1.3.16 ]
114700207 Camk2g; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515 ] [EC:2.7.11.17 ]
114700550 Apaf1; apoptotic protease-activating factor 1 isoform X1 [KO:K02084 ]
114701415 Clec7a; C-type lectin domain family 7 member A isoform X2 [KO:K10074 ]
114704508 Atp6v0a2; LOW QUALITY PROTEIN: V-type proton ATPase 116 kDa subunit a2 [KO:K02154 ]
114704926 Nfyc; nuclear transcription factor Y subunit gamma isoform X1 [KO:K08066 ]
114705035 Stat1; signal transducer and activator of transcription 1-alpha/beta [KO:K11220 ]
114705057 Creb1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870 ]
114705140 Cd14; LOW QUALITY PROTEIN: monocyte differentiation antigen CD14 [KO:K04391 ]
114706839 Atp6v0a4; V-type proton ATPase 116 kDa subunit a isoform X1 [KO:K02154 ]
114707373 Cd74; HLA class II histocompatibility antigen gamma chain isoform X1 [KO:K06505 ]
114707396 Camk2a; LOW QUALITY PROTEIN: calcium/calmodulin-dependent protein kinase type II subunit alpha [KO:K04515 ] [EC:2.7.11.17 ]
114708260 Calml6; LOW QUALITY PROTEIN: calmodulin-like protein 6 [KO:K02183 ]
114708503 Nod2; LOW QUALITY PROTEIN: nucleotide-binding oligomerization domain-containing protein 2 [KO:K10165 ]
114708799 Tnfrsf1a; LOW QUALITY PROTEIN: tumor necrosis factor receptor superfamily member 1A [KO:K03158 ]
114709373 Atp6v0b; V-type proton ATPase 21 kDa proteolipid subunit [KO:K03661 ]
114709763 Lamp2; LOW QUALITY PROTEIN: lysosome-associated membrane glycoprotein 2 [KO:K06528 ]
119086087 Fcgr2a; low affinity immunoglobulin gamma Fc region receptor II-a isoform X1 [KO:K06472 ]
Compound C01194 1-Phosphatidyl-D-myo-inositol
C04549 1-Phosphatidyl-1D-myo-inositol 3-phosphate
C06124 Sphingosine 1-phosphate
C19190 Trehalose-6,6'-dibehenate
C21790 Mycobacterial trehalose dimycolate
G13105 Triacylated phosphatidyl-myo-inositol pentamannoside
G13106 Triacylated phosphatidyl-myo-inositol hexamannoside
G13108 Triacylated phosphatidyl-myo-inositol dimannoside
G13109 Tetraacylated phosphatidyl-myo-inositol dimannoside
G13112 Tetraacylated phosphatidyl-myo-inositol hexamannoside
G13113 Tetraacylated phosphatidyl-myo-inositol pentamannoside
G13115 Mannose-capped lipoarabinomannan
Reference Authors Saiga H, Shimada Y, Takeda K
Title Innate immune effectors in mycobacterial infection.
Journal Reference Authors Dheda K, Schwander SK, Zhu B, van Zyl-Smit RN, Zhang Y
Title The immunology of tuberculosis: from bench to bedside.
Journal Reference Authors van Crevel R, Ottenhoff TH, van der Meer JW
Title Innate immunity to Mycobacterium tuberculosis.
Journal Reference Authors Torrelles JB, Azad AK, Henning LN, Carlson TK, Schlesinger LS
Title Role of C-type lectins in mycobacterial infections.
Journal Reference Authors Jo EK, Yang CS, Choi CH, Harding CV
Title Intracellular signalling cascades regulating innate immune responses to Mycobacteria: branching out from Toll-like receptors.
Journal Reference Authors Marakalala MJ, Graham LM, Brown GD
Title The role of Syk/CARD9-coupled C-type lectin receptors in immunity to Mycobacterium tuberculosis infections.
Journal Reference Authors Koul A, Herget T, Klebl B, Ullrich A
Title Interplay between mycobacteria and host signalling pathways.
Journal Reference Authors Torrelles JB, Schlesinger LS
Title Diversity in Mycobacterium tuberculosis mannosylated cell wall determinants impacts adaptation to the host.
Journal Reference Authors Briken V, Porcelli SA, Besra GS, Kremer L
Title Mycobacterial lipoarabinomannan and related lipoglycans: from biogenesis to modulation of the immune response.
Journal Reference Authors Baena A, Porcelli SA
Title Evasion and subversion of antigen presentation by Mycobacterium tuberculosis.
Journal Reference Authors Flannagan RS, Cosio G, Grinstein S
Title Antimicrobial mechanisms of phagocytes and bacterial evasion strategies.
Journal Reference Authors Pieters J
Title Mycobacterium tuberculosis and the macrophage: maintaining a balance.
Journal Reference Authors Scherr N, Jayachandran R, Mueller P, Pieters J
Title Interference of Mycobacterium tuberculosis with macrophage responses.
Journal Indian J Exp Biol 47:401-6 (2009)
Reference Authors Reith W, LeibundGut-Landmann S, Waldburger JM.
Title Regulation of MHC class II gene expression by the class II transactivator.
Journal Reference Authors Rothfuchs AG, Bafica A, Feng CG, Egen JG, Williams DL, Brown GD, Sher A
Title Dectin-1 interaction with Mycobacterium tuberculosis leads to enhanced IL-12p40 production by splenic dendritic cells.
Journal Reference Authors Master SS, Rampini SK, Davis AS, Keller C, Ehlers S, Springer B, Timmins GS, Sander P, Deretic V
Title Mycobacterium tuberculosis prevents inflammasome activation.
Journal Reference Authors Shtrichman R, Samuel CE
Title The role of gamma interferon in antimicrobial immunity.
Journal Related pleu04612 Antigen processing and presentation
pleu04620 Toll-like receptor signaling pathway
pleu04621 NOD-like receptor signaling pathway
KO pathway
