KEGG   PATHWAY: pvp05168
Entry
pvp05168                    Pathway                                
Name
Herpes simplex virus 1 infection - Pteropus vampyrus (large flying fox)
Description
Herpes simplex virus 1(HSV-1) is a common human pathogen, which initially infects orofacial mucosal surfaces. The virus replicates in epithelial cells at these sites, causing clinically overt disease characterized by vesicular lesions. HSV-1 then penetrates to the nervous system and establishes latency in sensory neurons. Throughout the lifetime of the host, HSV-1 may reactivate from its latent state and reinitiate a lytic infection cycle. HSV-1 has developed various mechanisms to escape its host innate immune responses and increased its capacity to replicate and to persist. ICP34.5, ICP0, ICP27, Us11 and Vhs (UL41) are the proteins involved in viral interference.
Class
Human Diseases; Infectious disease: viral
Pathway map
pvp05168  Herpes simplex virus 1 infection
pvp05168

Disease
H00365  Herpes simplex virus infection
Organism
Pteropus vampyrus (large flying fox) [GN:pvp]
Gene
105288270  APAF1; apoptotic protease-activating factor 1 [KO:K02084]
105288381  SRSF3; serine/arginine-rich splicing factor 3 [KO:K12892]
105288697  PDIA3; protein disulfide-isomerase A3 [KO:K08056] [EC:5.3.4.1]
105288712  B2M; beta-2-microglobulin isoform X2 [KO:K08055]
105289170  EIF2B1; translation initiation factor eIF-2B subunit alpha [KO:K03239]
105289220  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
105289236  PTPN11; tyrosine-protein phosphatase non-receptor type 11 [KO:K07293] [EC:3.1.3.48]
105289237  [KO:K14216] [EC:2.7.7.84]
105289277  SRSF9; serine/arginine-rich splicing factor 9 isoform X1 [KO:K21123]
105289309  STAT1; signal transducer and activator of transcription 1-alpha/beta [KO:K11220]
105289390  OAS2; LOW QUALITY PROTEIN: 2'-5'-oligoadenylate synthase 2 [KO:K14216] [EC:2.7.7.84]
105289440  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1 [KO:K04404]
105289469  IFNGR1; interferon gamma receptor 1 [KO:K05132]
105289725  EIF2B4; translation initiation factor eIF-2B subunit delta isoform X1 [KO:K03680]
105289903  IL12B; interleukin-12 subunit beta [KO:K05425]
105290063  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
105290546  SRSF4; serine/arginine-rich splicing factor 4 [KO:K12893]
105291001  IFIH1; interferon-induced helicase C domain-containing protein 1 isoform X1 [KO:K12647] [EC:5.6.2.6]
105291226  TP53; cellular tumor antigen p53 isoform X1 [KO:K04451]
105291526  TLR2; toll-like receptor 2 [KO:K10159]
105291619  ZC3HAV1; zinc finger CCCH-type antiviral protein 1 isoform X1 [KO:K28004]
105291966  [KO:K14624]
105292665  C5; complement C5 [KO:K03994]
105292717  BCL2; apoptosis regulator Bcl-2 isoform X2 [KO:K02161]
105292873  RNASEL; 2-5A-dependent ribonuclease isoform X1 [KO:K01165]
105292955  SRSF7; serine/arginine-rich splicing factor 7 isoform X1 [KO:K12896]
105292967  EIF2AK2; interferon-induced, double-stranded RNA-activated protein kinase [KO:K16195] [EC:2.7.11.1]
105293029  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
105293104  FAS; tumor necrosis factor receptor superfamily member 6 isoform X5 [KO:K04390]
105293152  IL6; interleukin-6 isoform X2 [KO:K05405]
105293163  [KO:K08738]
105293447  SOCS3; suppressor of cytokine signaling 3 [KO:K04696]
105293481  [KO:K06751]
105294412  CASP9; caspase-9 [KO:K04399] [EC:3.4.22.62]
105294429  MTOR; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
105294691  TLR3; toll-like receptor 3 [KO:K05401]
105294710  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
105295002  TRAF5; TNF receptor-associated factor 5 isoform X2 [KO:K09849]
105295639  MYD88; myeloid differentiation primary response protein MyD88 [KO:K04729]
105295851  IFNGR2; interferon gamma receptor 2 isoform X1 [KO:K05133]
105295861  IFNAR1; interferon alpha/beta receptor 1 [KO:K05130]
105295974  TAPBPL; tapasin-related protein isoform X1 [KO:K28445]
105295979  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
105296513  SRC; proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
105296605  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
105296623  BST2; bone marrow stromal antigen 2 isoform X1 [KO:K06731]
105297002  MAP3K7; mitogen-activated protein kinase kinase kinase 7 [KO:K04427] [EC:2.7.11.25]
105297116  EIF2B3; translation initiation factor eIF-2B subunit gamma isoform X1 [KO:K03241]
105297140  [KO:K02649]
105297238  BID; BH3-interacting domain death agonist isoform X2 [KO:K04726]
105297357  NECTIN2; nectin-2 isoform X1 [KO:K06531]
105297485  IRAK4; interleukin-1 receptor-associated kinase 4 isoform X1 [KO:K04733] [EC:2.7.11.1]
105297818  NXF1; nuclear RNA export factor 1 isoform X1 [KO:K14284]
105297848  BAD; bcl2-associated agonist of cell death [KO:K02158]
105297999  RELA; transcription factor p65 [KO:K04735]
105298074  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 [KO:K04403]
105298127  CASP8; caspase-8 [KO:K04398] [EC:3.4.22.61]
105298242  SRSF6; serine/arginine-rich splicing factor 6 [KO:K12893]
105298277  BIRC3; baculoviral IAP repeat-containing protein 3 [KO:K16060]
105298278  BIRC2; baculoviral IAP repeat-containing protein 2 [KO:K16060]
105298360  JAK1; tyrosine-protein kinase JAK1 isoform X1 [KO:K11217] [EC:2.7.10.2]
105298437  [KO:K05414]
105298539  MAVS; mitochondrial antiviral-signaling protein [KO:K12648]
105298579  CARD9; caspase recruitment domain-containing protein 9 [KO:K12794]
105298613  TRAF2; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
105298655  TSC1; hamartin isoform X1 [KO:K07206]
105298702  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
105299132  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit isoform X1 [KO:K06269] [EC:3.1.3.16]
105299220  EIF2B2; translation initiation factor eIF-2B subunit beta isoform X1 [KO:K03754]
105299274  TRAF3; TNF receptor-associated factor 3 isoform X1 [KO:K03174]
105299371  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X3 [KO:K02649]
105299445  CD74; HLA class II histocompatibility antigen gamma chain [KO:K06505]
105299754  PILRA; paired immunoglobulin-like type 2 receptor alpha [KO:K15411]
105299797  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
105300159  [KO:K04456] [EC:2.7.11.1]
105300185  EIF4EBP1; eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
105300248  SYK; tyrosine-protein kinase SYK isoform X1 [KO:K05855] [EC:2.7.10.2]
105300734  IKBKE; LOW QUALITY PROTEIN: inhibitor of nuclear factor kappa-B kinase subunit epsilon [KO:K07211] [EC:2.7.11.10]
105300960  [KO:K06752]
105300961  [KO:K06752]
105300962  [KO:K06752]
105300964  [KO:K06752]
105300966  TAP1; antigen peptide transporter 1 isoform X1 [KO:K05653] [EC:7.4.2.14]
105300969  [KO:K06752]
105300971  [KO:K06752]
105300973  [KO:K06752]
105300989  TAPBP; tapasin isoform X1 [KO:K08058]
105300991  DAXX; death domain-associated protein 6 [KO:K02308]
105301000  [KO:K14021]
105301004  [KO:K06752]
105301022  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
105301033  SRPK1; SRSF protein kinase 1 isoform X1 [KO:K15409] [EC:2.7.11.1]
105301037  TAP2; antigen peptide transporter 2 [KO:K05654] [EC:7.4.2.14]
105301039  [KO:K06752]
105301058  TICAM1; TIR domain-containing adapter molecule 1 [KO:K05842]
105301084  TNFSF14; tumor necrosis factor ligand superfamily member 14 [KO:K05477]
105301109  C3; complement C3 [KO:K03990]
105301118  TBK1; serine/threonine-protein kinase TBK1 isoform X1 [KO:K05410] [EC:2.7.11.10]
105301169  ALYREF; THO complex subunit 4 [KO:K12881]
105301255  IFNAR2; interferon alpha/beta receptor 2 isoform X1 [KO:K05131]
105301262  IFNG; interferon gamma [KO:K04687]
105301512  POU2F1; POU domain, class 2, transcription factor 1 [KO:K09364]
105301733  IRF3; interferon regulatory factor 3 [KO:K05411]
105301762  BAX; apoptosis regulator BAX isoform X1 [KO:K02159]
105302133  SRSF1; serine/arginine-rich splicing factor 1 [KO:K12890]
105302488  HCFC1; host cell factor 1 isoform X1 [KO:K14966]
105302526  IRAK1; interleukin-1 receptor-associated kinase 1 isoform X1 [KO:K04730] [EC:2.7.11.1]
105302532  IKBKG; NF-kappa-B essential modulator [KO:K07210]
105302576  STAT2; signal transducer and activator of transcription 2 isoform X2 [KO:K11221]
105302702  ITGA5; integrin alpha-5 [KO:K06484]
105303182  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
105303192  JAK2; tyrosine-protein kinase JAK2 [KO:K04447] [EC:2.7.10.2]
105303335  TSC2; LOW QUALITY PROTEIN: tuberin [KO:K07207]
105303446  ITGB3; integrin beta-3 isoform X1 [KO:K06493]
105303777  RHEB; GTP-binding protein Rheb [KO:K07208]
105303899  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
105303982  IL1B; interleukin-1 beta [KO:K04519]
105304412  SRSF2; serine/arginine-rich splicing factor 2 [KO:K12891]
105304619  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
105304977  CCL5; C-C motif chemokine 5 [KO:K12499]
105305274  [KO:K06752]
105305325  TNF; tumor necrosis factor [KO:K03156]
105305326  LTA; lymphotoxin-alpha isoform X1 [KO:K05468]
105305333  [KO:K06752]
105305341  [KO:K06751]
105305460  CFP; properdin [KO:K15412]
105305503  BCL2L1; bcl-2-like protein 1 isoform X1 [KO:K04570]
105305596  TYK2; non-receptor tyrosine-protein kinase TYK2 isoform X1 [KO:K11219] [EC:2.7.10.2]
105305700  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
105305876  IL12A; interleukin-12 subunit alpha [KO:K05406]
105305954  IRF7; interferon regulatory factor 7 [KO:K09447]
105306113  CGAS; cyclic GMP-AMP synthase isoform X1 [KO:K17834] [EC:2.7.7.86]
105306133  SP100; nuclear autoantigen Sp-100 isoform X1 [KO:K15413]
105306475  DDX58; probable ATP-dependent RNA helicase DDX58 [KO:K12646] [EC:5.6.2.6]
105306822  PML; protein PML isoform X3 [KO:K10054] [EC:2.3.2.-]
105306956  TMEM173; stimulator of interferon genes protein [KO:K12654]
105307160  EIF2B5; translation initiation factor eIF-2B subunit epsilon [KO:K03240]
105307175  CALR; calreticulin [KO:K08057]
105307215  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
105307347  POU2F2; POU domain, class 2, transcription factor 2 isoform X4 [KO:K09364]
105307475  FADD; FAS-associated death domain protein [KO:K02373]
105307575  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
105307932  SRSF5; serine/arginine-rich splicing factor 5 isoform X1 [KO:K12893]
105308073  NXF5; nuclear RNA export factor 5 [KO:K14284]
105308244  EIF2S1; eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
105308875  NECTIN1; nectin-1 isoform X2 [KO:K06081]
105308956  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X2 [KO:K00922] [EC:2.7.1.153]
105309141  IFNB1; interferon beta [KO:K05415]
105309143  [KO:K05414]
105309144  [KO:K05414]
105309148  [KO:K05414]
105309227  [KO:K06752]
105309384  IRF9; interferon regulatory factor 9 isoform X1 [KO:K04693]
105309514  POU2F3; POU domain, class 2, transcription factor 3 [KO:K09364]
105309601  [KO:K06751]
105309828  [KO:K07293] [EC:3.1.3.48]
105309848  [KO:K06751]
105309864  [KO:K06751]
105309924  PPP1CA; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
105310129  [KO:K06751]
105310204  [KO:K06752]
105310338  [KO:K06752]
105310642  [KO:K04730] [EC:2.7.11.1]
105310788  [KO:K14284]
105310789  HCFC2; host cell factor 2 [KO:K27390]
105311725  [KO:K06751]
105311736  [KO:K05152]
111728746  [KO:K14021]
Compound
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C20640  Cyclic GMP-AMP
C20935  2-5A
Reference
PMID:12787566
  Authors
Granger SW, Rickert S
  Title
LIGHT-HVEM signaling and the regulation of T cell-mediated immunity.
  Journal
Cytokine Growth Factor Rev 14:289-96 (2003)
DOI:10.1016/S1359-6101(03)00031-5
Reference
PMID:19495760
  Authors
Steinberg MW, Shui JW, Ware CF, Kronenberg M
  Title
Regulating the mucosal immune system: the contrasting roles of LIGHT, HVEM, and their various partners.
  Journal
Semin Immunopathol 31:207-21 (2009)
DOI:10.1007/s00281-009-0157-4
Reference
PMID:20221426
  Authors
MacLeod IJ, Minson T
  Title
Binding of herpes simplex virus type-1 virions leads to the induction of intracellular signalling in the absence of virus entry.
  Journal
PLoS One 5:e9560 (2010)
DOI:10.1371/journal.pone.0009560
Reference
PMID:23150579
  Authors
Gianni T, Leoni V, Chesnokova LS, Hutt-Fletcher LM, Campadelli-Fiume G
  Title
alphavbeta3-integrin is a major sensor and activator of innate immunity to herpes simplex virus-1.
  Journal
Proc Natl Acad Sci U S A 109:19792-7 (2012)
DOI:10.1073/pnas.1212597109
Reference
PMID:25375272
  Authors
Gianni T, Campadelli-Fiume G
  Title
The epithelial alphavbeta3-integrin boosts the MYD88-dependent TLR2 signaling in response to viral and bacterial components.
  Journal
PLoS Pathog 10:e1004477 (2014)
DOI:10.1371/journal.ppat.1004477
Reference
PMID:15056211
  Authors
Spear PG
  Title
Herpes simplex virus: receptors and ligands for cell entry.
  Journal
Cell Microbiol 6:401-10 (2004)
DOI:10.1111/j.1462-5822.2004.00389.x
Reference
PMID:12855695
  Authors
Boutell C, Everett RD
  Title
The herpes simplex virus type 1 (HSV-1) regulatory protein ICP0 interacts with and Ubiquitinates p53.
  Journal
J Biol Chem 278:36596-602 (2003)
DOI:10.1074/jbc.M300776200
Reference
PMID:24262390
  Authors
Ma Y, He B
  Title
Recognition of herpes simplex viruses: toll-like receptors and beyond.
  Journal
J Mol Biol 426:1133-47 (2014)
DOI:10.1016/j.jmb.2013.11.012
Reference
PMID:26952111
  Authors
Su C, Zhan G, Zheng C
  Title
Evasion of host antiviral innate immunity by HSV-1, an update.
  Journal
Virol J 13:38 (2016)
DOI:10.1186/s12985-016-0495-5
Reference
PMID:21994567
  Authors
Melchjorsen J, Matikainen S, Paludan SR
  Title
Activation and evasion of innate antiviral immunity by herpes simplex virus.
  Journal
Viruses 1:737-59 (2009)
DOI:10.3390/v1030737
Reference
PMID:15276609
  Authors
Morrison LA
  Title
The Toll of herpes simplex virus infection.
  Journal
Trends Microbiol 12:353-6 (2004)
DOI:10.1016/j.tim.2004.06.001
Reference
PMID:29298887
  Authors
Zheng C
  Title
Evasion of Cytosolic DNA-Stimulated Innate Immune Responses by Herpes Simplex Virus 1.
  Journal
J Virol 92:e00099-17 (2018)
DOI:10.1128/JVI.00099-17
Reference
PMID:19344302
  Authors
Grandi P, Peruzzi P, Reinhart B, Cohen JB, Chiocca EA, Glorioso JC
  Title
Design and application of oncolytic HSV vectors for glioblastoma therapy.
  Journal
Expert Rev Neurother 9:505-17 (2009)
DOI:10.1586/ern.09.9
Reference
PMID:23115300
  Authors
Lussignol M, Queval C, Bernet-Camard MF, Cotte-Laffitte J, Beau I, Codogno P, Esclatine A
  Title
The herpes simplex virus 1 Us11 protein inhibits autophagy through its interaction with the protein kinase PKR.
  Journal
J Virol 87:859-71 (2013)
DOI:10.1128/JVI.01158-12
Reference
PMID:17229694
  Authors
Sanchez R, Mohr I
  Title
Inhibition of cellular 2'-5' oligoadenylate synthetase by the herpes simplex virus type 1 Us11 protein.
  Journal
J Virol 81:3455-64 (2007)
DOI:10.1128/JVI.02520-06
Reference
PMID:12826401
  Authors
Wysocka J, Herr W
  Title
The herpes simplex virus VP16-induced complex: the makings of a regulatory switch.
  Journal
Trends Biochem Sci 28:294-304 (2003)
DOI:10.1016/S0968-0004(03)00088-4
Reference
PMID:27367734
  Authors
Fleming SB
  Title
Viral Inhibition of the IFN-Induced JAK/STAT Signalling Pathway: Development of Live Attenuated Vaccines by Mutation of Viral-Encoded IFN-Antagonists.
  Journal
Vaccines (Basel) 4:23 (2016)
DOI:10.3390/vaccines4030023
Reference
PMID:15163721
  Authors
Yokota S, Yokosawa N, Okabayashi T, Suzutani T, Miura S, Jimbow K, Fujii N
  Title
Induction of suppressor of cytokine signaling-3 by herpes simplex virus type 1 contributes to inhibition of the interferon signaling pathway.
  Journal
J Virol 78:6282-6 (2004)
DOI:10.1128/JVI.78.12.6282-6286.2004
Reference
PMID:23864622
  Authors
Gu H, Zheng Y, Roizman B
  Title
Interaction of herpes simplex virus ICP0 with ND10 bodies: a sequential process of adhesion, fusion, and retention.
  Journal
J Virol 87:10244-54 (2013)
DOI:10.1128/JVI.01487-13
Reference
PMID:21994592
  Authors
Tavalai N, Stamminger T
  Title
Interplay between Herpesvirus Infection and Host Defense by PML Nuclear Bodies.
  Journal
Viruses 1:1240-64 (2009)
DOI:10.3390/v1031240
Reference
PMID:21146386
  Authors
Horst D, Verweij MC, Davison AJ, Ressing ME, Wiertz EJ
  Title
Viral evasion of T cell immunity: ancient mechanisms offering new applications.
  Journal
Curr Opin Immunol 23:96-103 (2011)
DOI:10.1016/j.coi.2010.11.005
Reference
PMID:12960333
  Authors
Neumann J, Eis-Hubinger AM, Koch N
  Title
Herpes simplex virus type 1 targets the MHC class II processing pathway for immune evasion.
  Journal
J Immunol 171:3075-83 (2003)
DOI:10.4049/jimmunol.171.6.3075
Reference
PMID:25798530
  Authors
Liu X, Cohen JI
  Title
The role of PI3K/Akt in human herpesvirus infection: From the bench to the bedside.
  Journal
Virology 479-480:568-77 (2015)
DOI:10.1016/j.virol.2015.02.040
Reference
PMID:28468873
  Authors
Vink EI, Smiley JR, Mohr I
  Title
Subversion of Host Responses to Energy Insufficiency by Us3 Supports Herpes Simplex Virus 1 Replication during Stress.
  Journal
J Virol 91:e00295-17 (2017)
DOI:10.1128/JVI.00295-17
Reference
PMID:18508584
  Authors
Sandri-Goldin RM
  Title
The many roles of the regulatory protein ICP27 during herpes simplex virus infection.
  Journal
Front Biosci 13:5241-56 (2008)
DOI:10.2741/3078
Reference
PMID:15078920
  Authors
Sandri-Goldin RM
  Title
Viral regulation of mRNA export.
  Journal
J Virol 78:4389-96 (2004)
DOI:10.1128/JVI.78.9.4389-4396.2004
Reference
PMID:27154074
  Authors
Yu X, He S
  Title
The interplay between human herpes simplex virus infection and the apoptosis and necroptosis cell death pathways.
  Journal
Virol J 13:77 (2016)
DOI:10.1186/s12985-016-0528-0
Related
pathway
pvp03040  Spliceosome
pvp03050  Proteasome
pvp04115  p53 signaling pathway
pvp04151  PI3K-Akt signaling pathway
pvp04210  Apoptosis
pvp04610  Complement and coagulation cascades
pvp04612  Antigen processing and presentation
pvp04620  Toll-like receptor signaling pathway
pvp04622  RIG-I-like receptor signaling pathway
pvp04630  JAK-STAT signaling pathway
KO pathway
ko05168   

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