KEGG   PATHWAY: tge04020
Entry
tge04020                    Pathway                                
Name
Calcium signaling pathway - Theropithecus gelada (gelada)
Description
Ca2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this external source of signal Ca2+ by activating various entry channels with widely different properties. The voltage-operated channels (VOCs) are found in excitable cells and generate the rapid Ca2+ fluxes that control fast cellular processes. There are many other Ca2+-entry channels, such as the receptor-operated channels (ROCs), for example the NMDA (N-methyl-D-aspartate) receptors (NMDARs) that respond to glutamate. There also are second-messenger-operated channels (SMOCs) and store-operated channels (SOCs).
The other principal source of Ca2+ for signalling is the internal stores that are located primarily in the endoplasmic/sarcoplasmic reticulum (ER/SR), in which inositol-1,4,5-trisphosphate receptors (IP3Rs) or ryanodine receptors (RYRs) regulate the release of Ca2+. The principal activator of these channels is Ca2+ itself and this process of Ca2+-induced Ca2+ release is central to the mechanism of Ca2+ signalling. Various second messengers or modulators also control the release of Ca2+. IP3, which is generated by pathways using different isoforms of phospholipase C (PLCbeta, delta, epsilon, gamma and zeta), regulates the IP3Rs. Cyclic ADP-ribose (cADPR) releases Ca2+ via RYRs. Nicotinic acid adenine dinucleotide phosphate (NAADP) may activate a distinct Ca2+ release mechanism on separate acidic Ca2+ stores. Ca2+ release via the NAADP-sensitive mechanism may also feedback onto either RYRs or IP3Rs. cADPR and NAADP are generated by CD38. This enzyme might be sensitive to the cellular metabolism, as ATP and NADH inhibit it.
The influx of Ca2+ from the environment or release from internal stores causes a very rapid and dramatic increase in cytoplasmic calcium concentration, which has been widely exploited for signal transduction. Some proteins, such as troponin C (TnC) involved in muscle contraction, directly bind to and sense Ca2+. However, in other cases Ca2+ is sensed through intermediate calcium sensors such as calmodulin (CALM).
Class
Environmental Information Processing; Signal transduction
Pathway map
tge04020  Calcium signaling pathway
tge04020

Other DBs
GO: 0019722
Organism
Theropithecus gelada (gelada) [GN:tge]
Gene
112604540  ADCY3; adenylate cyclase type 3 isoform X1 [KO:K08043] [EC:4.6.1.1]
112604653  TGFA; protransforming growth factor alpha isoform X1 [KO:K08774]
112604751  PPP3R1; calcineurin subunit B type 1 isoform X1 [KO:K06268]
112604814  TACR1; substance-P receptor [KO:K04222]
112604819  LHCGR; lutropin-choriogonadotropic hormone receptor [KO:K04248]
112604879  SLC8A1; sodium/calcium exchanger 1 isoform X1 [KO:K05849]
112605737  CHRM1; muscarinic acetylcholine receptor M1 [KO:K04129]
112606262  STIM1; stromal interaction molecule 1 isoform X1 [KO:K16059]
112606283  HTR6; 5-hydroxytryptamine receptor 6 [KO:K04162]
112606361  GRM5; metabotropic glutamate receptor 5 [KO:K04604]
112606377  SLN; sarcolipin [KO:K22642]
112606555  CCKBR; gastrin/cholecystokinin type B receptor isoform X1 [KO:K04195]
112606682  P2RX3; P2X purinoceptor 3 [KO:K05217]
112606810  FGF19; fibroblast growth factor 19 [KO:K22603]
112606831  FGF4; fibroblast growth factor 4 [KO:K04358]
112606868  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
112607006  NTRK1; high affinity nerve growth factor receptor isoform X1 [KO:K03176] [EC:2.7.10.1]
112607217  FGF3; fibroblast growth factor 3 [KO:K04358]
112607256  VEGFB; vascular endothelial growth factor B isoform X1 [KO:K16858]
112607288  TPCN2; two pore calcium channel protein 2 [KO:K14077]
112607332  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform X1 [KO:K05858] [EC:3.1.4.11]
112607764  AVPR1B; vasopressin V1b receptor [KO:K04227]
112607806  NTRK2; BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
112607858  GNAQ; guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
112607972  CACNA1B; LOW QUALITY PROTEIN: voltage-dependent N-type calcium channel subunit alpha-1B [KO:K04849]
112608036  GNA14; guanine nucleotide-binding protein subunit alpha-14 [KO:K04636]
112608183  PRKACG; cAMP-dependent protein kinase catalytic subunit gamma [KO:K04345] [EC:2.7.11.11]
112608539  GRIN1; glutamate receptor ionotropic, NMDA 1 [KO:K05208]
112608614  NGF; beta-nerve growth factor [KO:K02582]
112608620  GRIN3A; glutamate receptor ionotropic, NMDA 3A [KO:K05213]
112608621  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
112608874  SMIM6; small integral membrane protein 6 [KO:K26468]
112608876  CACNA1G; voltage-dependent T-type calcium channel subunit alpha-1G isoform X1 [KO:K04854]
112608916  SPHK1; sphingosine kinase 1 isoform X1 [KO:K04718] [EC:2.7.1.91]
112608971  ERBB2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
112609174  CALML6; calmodulin-like protein 6 isoform X1 [KO:K02183]
112609260  GRIN2C; glutamate receptor ionotropic, NMDA 2C [KO:K05211]
112609528  ADORA2B; adenosine receptor A2b [KO:K04267]
112609630  P2RX1; P2X purinoceptor 1 [KO:K05215]
112609643  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
112609647  ATP2A3; sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform X1 [KO:K05853] [EC:7.2.2.10]
112609895  NOS2; nitric oxide synthase, inducible [KO:K13241] [EC:1.14.13.39]
112610170  P2RX5; P2X purinoceptor 5 [KO:K05219]
112610393  PLCD3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 isoform X1 [KO:K05857] [EC:3.1.4.11]
112610592  FGF9; fibroblast growth factor 9 [KO:K04358]
112610739  EDNRB; endothelin receptor type B isoform X1 [KO:K04198]
112610885  FLT1; vascular endothelial growth factor receptor 1 isoform X1 [KO:K05096] [EC:2.7.10.1]
112610969  CYSLTR2; cysteinyl leukotriene receptor 2 [KO:K04323]
112611173  HTR2A; 5-hydroxytryptamine receptor 2A isoform X1 [KO:K04157]
112611291  GNAL; guanine nucleotide-binding protein G(olf) subunit alpha isoform X1 [KO:K04633]
112611402  [KO:K05863]
112611467  CHRM3; muscarinic acetylcholine receptor M3 [KO:K04131]
112612039  MCOLN1; mucolipin-1 [KO:K04992]
112612290  GRIN3B; glutamate receptor ionotropic, NMDA 3B [KO:K05214]
112612323  FGF22; LOW QUALITY PROTEIN: fibroblast growth factor 22 [KO:K04358]
112612325  SPHK2; sphingosine kinase 2 isoform X1 [KO:K04718] [EC:2.7.1.91]
112612415  ITPKC; inositol-trisphosphate 3-kinase C [KO:K00911] [EC:2.7.1.127]
112612423  CALM3; calmodulin-3 isoform X1 [KO:K02183]
112612428  CACNA1A; voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform X1 [KO:K04344]
112612552  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
112612600  PTGER1; prostaglandin E2 receptor EP1 subtype [KO:K04258]
112612765  SLC8A2; sodium/calcium exchanger 2 isoform X1 [KO:K05849]
112612781  GNA15; guanine nucleotide-binding protein subunit alpha-15 [KO:K04637]
112612853  GRIN2D; glutamate receptor ionotropic, NMDA 2D [KO:K05212]
112612879  GNA11; guanine nucleotide-binding protein subunit alpha-11 isoform X1 [KO:K04635]
112612978  TBXA2R; thromboxane A2 receptor [KO:K04264]
112612981  HRC; sarcoplasmic reticulum histidine-rich calcium-binding protein [KO:K23450]
112613317  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
112613542  FGF21; fibroblast growth factor 21 [KO:K22429]
112613556  RYR1; ryanodine receptor 1 isoform X1 [KO:K04961]
112613732  ATP2A1; sarcoplasmic/endoplasmic reticulum calcium ATPase 1 isoform X1 [KO:K05853] [EC:7.2.2.10]
112613788  PHKG2; phosphorylase b kinase gamma catalytic chain, liver/testis isoform isoform X1 [KO:K00871] [EC:2.7.11.19]
112613998  ADCY7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
112614034  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
112614052  CACNA1H; voltage-dependent T-type calcium channel subunit alpha-1H isoform X1 [KO:K04855]
112614067  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
112614148  ORAI3; protein orai-3 isoform X1 [KO:K16058]
112614190  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
112614388  MYLK3; myosin light chain kinase 3 isoform X1 [KO:K00907] [EC:2.7.11.18]
112614524  ADCY9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
112614685  GRIN2A; glutamate receptor ionotropic, NMDA 2A isoform X1 [KO:K05209]
112614698  PHKB; phosphorylase b kinase regulatory subunit beta isoform X1 [KO:K07190]
112614995  CACNA1F; voltage-dependent L-type calcium channel subunit alpha-1F [KO:K04853]
112615070  ATP2B3; plasma membrane calcium-transporting ATPase 3 isoform X1 [KO:K05850] [EC:7.2.2.10]
112615397  SLC25A5; ADP/ATP translocase 2 isoform X1 [KO:K05863]
112615425  SLC25A6; ADP/ATP translocase 3 isoform X1 [KO:K05863]
112615464  PHKA1; phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform isoform X1 [KO:K07190]
112615509  PHKA2; phosphorylase b kinase regulatory subunit alpha, liver isoform [KO:K07190]
112615650  HTR2C; 5-hydroxytryptamine receptor 2C isoform X1 [KO:K04157]
112615683  VEGFD; vascular endothelial growth factor D [KO:K05449]
112615917  CYSLTR1; cysteinyl leukotriene receptor 1 [KO:K04322]
112616084  GRPR; gastrin-releasing peptide receptor [KO:K04169]
112616411  FGF16; fibroblast growth factor 16 [KO:K04358]
112617130  [KO:K04161]
112617173  [KO:K04161]
112617368  MST1; hepatocyte growth factor-like protein [KO:K23441]
112617755  PTGER3; prostaglandin E2 receptor EP3 subtype isoform X1 [KO:K04260]
112618209  TNNC1; troponin C, slow skeletal and cardiac muscles [KO:K05865]
112618467  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
112618470  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 [KO:K04958]
112618667  CAMK1; calcium/calmodulin-dependent protein kinase type 1 isoform X1 [KO:K08794] [EC:2.7.11.17]
112618692  AGTR1; type-1 angiotensin II receptor isoform X1 [KO:K04166]
112618735  HRH1; histamine H1 receptor [KO:K04149]
112618864  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
112619004  PLCD1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 isoform X1 [KO:K05857] [EC:3.1.4.11]
112619106  MST1R; macrophage-stimulating protein receptor isoform X1 [KO:K05100] [EC:2.7.10.1]
112619234  ATP2B2; plasma membrane calcium-transporting ATPase 2 isoform X1 [KO:K05850] [EC:7.2.2.10]
112619273  MYLK; myosin light chain kinase, smooth muscle isoform X1 [KO:K00907] [EC:2.7.11.18]
112619593  OXTR; oxytocin receptor [KO:K04229]
112619808  PTAFR; platelet-activating factor receptor [KO:K04279]
112620011  PDGFA; platelet-derived growth factor subunit A [KO:K04359]
112620091  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
112620149  PHKG1; phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform isoform X1 [KO:K00871] [EC:2.7.11.19]
112620195  [KO:K10785]
112620205  [KO:K10785]
112620359  NOS3; nitric oxide synthase, endothelial isoform X1 [KO:K13242] [EC:1.14.13.39]
112620430  ORAI2; protein orai-2 isoform X1 [KO:K16057]
112620515  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
112620574  MET; hepatocyte growth factor receptor isoform X1 [KO:K05099] [EC:2.7.10.1]
112620879  CHRM2; muscarinic acetylcholine receptor M2 [KO:K04130]
112620898  HTR5A; 5-hydroxytryptamine receptor 5A [KO:K04161]
112620936  ADCY1; adenylate cyclase type 1 isoform X1 [KO:K08041] [EC:4.6.1.1]
112620941  CASQ1; calsequestrin-1 [KO:K23468]
112621199  ATP2B4; plasma membrane calcium-transporting ATPase 4 isoform X1 [KO:K05850] [EC:7.2.2.10]
112621278  PDE1C; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform X1 [KO:K13755] [EC:3.1.4.17]
112621713  [KO:K10785]
112621718  [KO:K10785]
112621751  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
112622646  GRM1; metabotropic glutamate receptor 1 [KO:K04603]
112622794  VEGFA; vascular endothelial growth factor A isoform X1 [KO:K05448]
112622816  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
112622861  PLN; cardiac phospholamban [KO:K05852]
112622922  TRDN; triadin isoform X1 [KO:K23449]
112623401  MYLK4; myosin light chain kinase family member 4 [KO:K00907] [EC:2.7.11.18]
112623752  TFEB; transcription factor EB isoform X1 [KO:K15590]
112624412  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X1 [KO:K04515] [EC:2.7.11.17]
112624445  TACR3; neuromedin-K receptor [KO:K04224]
112624454  CD38; ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 [KO:K01242] [EC:3.2.2.6 2.4.99.20]
112624522  KDR; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
112624557  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
112624598  DRD5; D(1B) dopamine receptor [KO:K05840]
112624610  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
112624619  FGF2; fibroblast growth factor 2 [KO:K18497]
112624771  SLC25A4; ADP/ATP translocase 1 isoform X1 [KO:K05863]
112624782  SLC25A31; ADP/ATP translocase 4 [KO:K05863]
112624795  FGF5; fibroblast growth factor 5 isoform X1 [KO:K04358]
112624796  CACNA1E; voltage-dependent R-type calcium channel subunit alpha-1E isoform X1 [KO:K04852]
112625061  EDNRA; endothelin-1 receptor isoform X1 [KO:K04197]
112625154  PDGFRA; platelet-derived growth factor receptor alpha isoform X1 [KO:K04363] [EC:2.7.10.1]
112625191  STIM2; stromal interaction molecule 2 isoform X1 [KO:K18196]
112625207  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
112625257  CCKAR; cholecystokinin receptor type A [KO:K04194]
112625319  C5H4orf3; uncharacterized protein C4orf3 homolog [KO:K26467]
112625330  PDGFC; platelet-derived growth factor C [KO:K05450]
112625469  VEGFC; vascular endothelial growth factor C isoform X1 [KO:K05449]
112625752  VDAC1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
112625819  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
112625837  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
112625956  ADCY2; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
112625972  FGFR4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
112626099  CAMK4; calcium/calmodulin-dependent protein kinase type IV isoform X1 [KO:K05869] [EC:2.7.11.17]
112626117  PDGFRB; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
112626121  FLT4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
112626218  FGF1; fibroblast growth factor 1 isoform X1 [KO:K18496]
112626221  ADRB2; beta-2 adrenergic receptor [KO:K04142]
112626293  CAMK1G; calcium/calmodulin-dependent protein kinase type 1G [KO:K08794] [EC:2.7.11.17]
112626315  HTR4; 5-hydroxytryptamine receptor 4 isoform X1 [KO:K04160]
112626373  FGF18; fibroblast growth factor 18 [KO:K04358]
112626403  FGF10; fibroblast growth factor 10 [KO:K04358]
112626503  DRD1; D(1A) dopamine receptor [KO:K04144]
112626543  HRH2; histamine H2 receptor isoform X1 [KO:K04150]
112626605  F2R; proteinase-activated receptor 1 isoform X1 [KO:K03914]
112626945  ADRA1B; alpha-1B adrenergic receptor [KO:K04136]
112627143  GDNF; glial cell line-derived neurotrophic factor isoform X1 [KO:K05452]
112627237  CASQ2; calsequestrin-2 isoform X1 [KO:K23445]
112627411  CALML4; LOW QUALITY PROTEIN: calmodulin-like protein 4 [KO:K02183]
112627584  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11]
112627602  CHRNA7; neuronal acetylcholine receptor subunit alpha-7 isoform X1 [KO:K04809]
112627661  RYR3; ryanodine receptor 3 isoform X1 [KO:K04963]
112627662  CHRM5; muscarinic acetylcholine receptor M5 [KO:K04133]
112627716  ITPKA; inositol-trisphosphate 3-kinase A [KO:K00911] [EC:2.7.1.127]
112628041  FGF7; fibroblast growth factor 7 isoform X1 [KO:K04358]
112628492  CALM1; calmodulin-1 isoform X1 [KO:K02183]
112628637  NFATC4; nuclear factor of activated T-cells, cytoplasmic 4 isoform X1 [KO:K17334]
112628706  SLC8A3; sodium/calcium exchanger 3 isoform X1 [KO:K05849]
112629228  NTRK3; NT-3 growth factor receptor isoform X1 [KO:K05101] [EC:2.7.10.1]
112629415  BDKRB2; B2 bradykinin receptor isoform X1 [KO:K03916]
112629416  BDKRB1; B1 bradykinin receptor isoform X1 [KO:K03915]
112629482  ADCY4; adenylate cyclase type 4 [KO:K08044] [EC:4.6.1.1]
112629485  LTB4R2; leukotriene B4 receptor 2 [KO:K04297]
112629696  ASPH; aspartyl/asparaginyl beta-hydroxylase isoform X1 [KO:K00476] [EC:1.14.11.16]
112629744  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
112629914  VDAC3; voltage-dependent anion-selective channel protein 3 isoform X1 [KO:K15041]
112630076  ADRA1A; alpha-1A adrenergic receptor isoform X1 [KO:K04135]
112630290  PTK2B; protein-tyrosine kinase 2-beta isoform X1 [KO:K05871] [EC:2.7.10.2]
112630332  ADCY8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
112630377  FGF17; fibroblast growth factor 17 isoform X1 [KO:K04358]
112630416  ADRB3; LOW QUALITY PROTEIN: beta-3 adrenergic receptor [KO:K04143]
112630471  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
112630484  FGF20; fibroblast growth factor 20 [KO:K04358]
112630576  TRHR; thyrotropin-releasing hormone receptor [KO:K04282]
112631163  VDAC2; voltage-dependent anion-selective channel protein 2 isoform X1 [KO:K15040]
112631173  PPIF; peptidyl-prolyl cis-trans isomerase F, mitochondrial [KO:K09565] [EC:5.2.1.8]
112631175  TACR2; substance-K receptor isoform X1 [KO:K04223]
112631191  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
112631360  MCU; calcium uniporter protein, mitochondrial isoform X1 [KO:K20858]
112631367  PLCE1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X1 [KO:K05860] [EC:3.1.4.11]
112631384  [KO:K02183]
112631469  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
112631475  RET; proto-oncogene tyrosine-protein kinase receptor Ret [KO:K05126] [EC:2.7.10.1]
112631500  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
112631589  CALML3; calmodulin-like protein 3 [KO:K02183]
112631715  HTR7; 5-hydroxytryptamine receptor 7 isoform X1 [KO:K04163]
112631736  ADRB1; beta-1 adrenergic receptor [KO:K04141]
112631767  CAMK1D; calcium/calmodulin-dependent protein kinase type 1D isoform X1 [KO:K08794] [EC:2.7.11.17]
112631781  FGF8; fibroblast growth factor 8 isoform X1 [KO:K04358]
112631867  CALML5; calmodulin-like protein 5 [KO:K02183]
112631893  MRLN; myoregulin [KO:K22643]
112632130  MCOLN3; mucolipin-3 isoform X1 [KO:K04994]
112632629  GNAS; guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas isoform X1 [KO:K04632]
112632630  [KO:K04632]
112632695  TNNC2; troponin C, skeletal muscle isoform X1 [KO:K12042]
112632711  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 [KO:K01116] [EC:3.1.4.11]
112632790  P2RX6; P2X purinoceptor 6 isoform X1 [KO:K05221]
112632883  NFATC2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332]
112632965  CACNA1I; voltage-dependent T-type calcium channel subunit alpha-1I [KO:K04856]
112633067  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
112633086  PDGFB; platelet-derived growth factor subunit B [KO:K17386]
112633206  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
112633275  MYLK2; myosin light chain kinase 2, skeletal/cardiac muscle [KO:K00907] [EC:2.7.11.18]
112633408  NTSR1; neurotensin receptor type 1 [KO:K04211]
112633462  ADRA1D; alpha-1D adrenergic receptor [KO:K04137]
112633739  ADORA2A; adenosine receptor A2a [KO:K04266]
112633960  ATP2A2; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 isoform X1 [KO:K05853] [EC:7.2.2.10]
112634000  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
112634345  ATP2B1; plasma membrane calcium-transporting ATPase 1 [KO:K05850] [EC:7.2.2.10]
112634420  RYR2; ryanodine receptor 2 [KO:K04962]
112634518  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
112634545  NOS1; nitric oxide synthase, brain [KO:K13240] [EC:1.14.13.39]
112634585  ERBB3; receptor tyrosine-protein kinase erbB-3 [KO:K05084] [EC:2.7.10.1]
112634597  ORAI1; calcium release-activated calcium channel protein 1 isoform X1 [KO:K16056]
112634637  TPCN1; two pore calcium channel protein 1 isoform X1 [KO:K16896]
112634649  MCOLN2; mucolipin-2 isoform X1 [KO:K04993]
112634666  PLCZ1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 isoform X1 [KO:K05861] [EC:3.1.4.11]
112634692  GRIN2B; glutamate receptor ionotropic, NMDA 2B [KO:K05210]
112634943  AVPR1A; vasopressin V1a receptor isoform X1 [KO:K04226]
112634976  P2RX2; P2X purinoceptor 2 [KO:K05216]
112635016  PTGFR; prostaglandin F2-alpha receptor [KO:K04262]
112635120  PDE1B; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B isoform X1 [KO:K13755] [EC:3.1.4.17]
112635290  P2RX4; P2X purinoceptor 4 isoform X1 [KO:K05218]
112635291  FGF23; fibroblast growth factor 23 [KO:K22428]
112635323  FGF6; fibroblast growth factor 6 [KO:K04358]
112635339  P2RX7; P2X purinoceptor 7 isoform X1 [KO:K05220]
112635665  ITPKB; inositol-trisphosphate 3-kinase B [KO:K00911] [EC:2.7.1.127]
112635932  PDE1A; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform X1 [KO:K13755] [EC:3.1.4.17]
112636253  PLCD4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 [KO:K05857] [EC:3.1.4.11]
112636377  CXCR4; LOW QUALITY PROTEIN: C-X-C chemokine receptor type 4 [KO:K04189]
112636548  ERBB4; receptor tyrosine-protein kinase erbB-4 isoform X1 [KO:K05085] [EC:2.7.10.1]
112636750  HTR2B; 5-hydroxytryptamine receptor 2B isoform X1 [KO:K04157]
112636897  CALM2; calmodulin-2 isoform X1 [KO:K02183]
Compound
C00002  ATP
C00004  NADH
C00076  Calcium cation
C00165  Diacylglycerol
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01330  Sodium cation
C06124  Sphingosine 1-phosphate
C11556  1-Phosphatidyl-1D-myo-inositol 3,5-bisphosphate
C13050  Cyclic ADP-ribose
C13051  Nicotinic acid adenine dinucleotide phosphate
Reference
PMID:12838335
  Authors
Berridge MJ, Bootman MD, Roderick HL.
  Title
Calcium signalling: dynamics, homeostasis and remodelling.
  Journal
Nat Rev Mol Cell Biol 4:517-29 (2003)
DOI:10.1038/nrm1155
Reference
PMID:11413485
  Authors
Berridge MJ, Lipp P, Bootman MD.
  Title
The versatility and universality of calcium signalling.
  Journal
Nat Rev Mol Cell Biol 1:11-21 (2000)
DOI:10.1038/35036035
Reference
PMID:15111104
  Authors
Wang MC, Dolphin A, Kitmitto A.
  Title
L-type voltage-gated calcium channels: understanding function through structure.
  Journal
FEBS Lett 564:245-50 (2004)
DOI:10.1016/S0014-5793(04)00253-4
Reference
PMID:11299192
  Authors
Ferrier GR, Howlett SE.
  Title
Cardiac excitation-contraction coupling: role of membrane potential in regulation of contraction.
  Journal
Am J Physiol Heart Circ Physiol 280:H1928-44 (2001)
DOI:10.1152/ajpheart.2001.280.5.H1928
Reference
PMID:11698232
  Authors
Keef KD, Hume JR, Zhong J.
  Title
Regulation of cardiac and smooth muscle Ca(2+) channels (Ca(V)1.2a,b) by protein kinases.
  Journal
Am J Physiol Cell Physiol 281:C1743-56 (2001)
DOI:10.1152/ajpcell.2001.281.6.C1743
Reference
PMID:8125957
  Authors
Hell JW, Appleyard SM, Yokoyama CT, Warner C, Catterall WA.
  Title
Differential phosphorylation of two size forms of the N-type calcium channel alpha 1 subunit which have different COOH termini.
  Journal
J Biol Chem 269:7390-6 (1994)
Reference
PMID:15000521
  Authors
Yunker AM.
  Title
Modulation and pharmacology of low voltage-activated ("T-Type") calcium channels.
  Journal
J Bioenerg Biomembr 35:577-98 (2003)
DOI:10.1023/B:JOBB.0000008025.65675.37
Reference
PMID:9149541
  Authors
Yakel JL.
  Title
Calcineurin regulation of synaptic function: from ion channels to transmitter release and gene transcription.
  Journal
Trends Pharmacol Sci 18:124-34 (1997)
DOI:10.1016/S0165-6147(97)01046-8
Reference
PMID:10997573
  Authors
Fukunaga K, Miyamoto E.
  Title
A working model of CaM kinase II activity in hippocampal long-term potentiation and memory.
  Journal
Neurosci Res 38:3-17 (2000)
DOI:10.1016/S0168-0102(00)00139-5
Reference
PMID:9235901
  Authors
Della Rocca GJ, van Biesen T, Daaka Y, Luttrell DK, Luttrell LM, Lefkowitz RJ.
  Title
Ras-dependent mitogen-activated protein kinase activation by G protein-coupled receptors. Convergence of Gi- and Gq-mediated pathways on calcium/calmodulin, Pyk2, and Src kinase.
  Journal
J Biol Chem 272:19125-32 (1997)
DOI:10.1074/jbc.272.31.19125
Reference
PMID:7861177
  Authors
Furuichi T, Mikoshiba K.
  Title
Inositol 1, 4, 5-trisphosphate receptor-mediated Ca2+ signaling in the brain.
  Journal
J Neurochem 64:953-60 (1995)
DOI:10.1046/j.1471-4159.1995.64030953.x
Reference
PMID:14572802
  Authors
Bruce JI, Straub SV, Yule DI.
  Title
Crosstalk between cAMP and Ca2+ signaling in non-excitable cells.
  Journal
Cell Calcium 34:431-44 (2003)
DOI:10.1016/S0143-4160(03)00150-7
Reference
PMID:10331643
  Authors
Lee HC, Munshi C, Graeff R.
  Title
Structures and activities of cyclic ADP-ribose, NAADP and their metabolic enzymes.
  Journal
Mol Cell Biochem 193:89-98 (1999)
DOI:10.1007/978-1-4419-8740-2_13
Reference
PMID:11080247
  Authors
Crompton M.
  Title
Mitochondrial intermembrane junctional complexes and their role in cell death.
  Journal
J Physiol 529 Pt 1:11-21 (2000)
DOI:10.1111/j.1469-7793.2000.00011.x
Reference
PMID:10508738
  Authors
Grewal SS, York RD, Stork PJ.
  Title
Extracellular-signal-regulated kinase signalling in neurons.
  Journal
Curr Opin Neurobiol 9:544-53 (1999)
DOI:10.1016/S0959-4388(99)00010-0
Reference
PMID:12972622
  Authors
Trushin SA, Pennington KN, Carmona EM, Asin S, Savoy DN, Billadeau DD, Paya CV.
  Title
Protein kinase Calpha (PKCalpha) acts upstream of PKCtheta to activate IkappaB kinase and NF-kappaB in T lymphocytes.
  Journal
Mol Cell Biol 23:7068-81 (2003)
DOI:10.1128/MCB.23.19.7068-7081.2003
Reference
PMID:14517314
  Authors
Hutchins JR, Dikovskaya D, Clarke PR.
  Title
Regulation of Cdc2/cyclin B activation in Xenopus egg extracts via inhibitory phosphorylation of Cdc25C phosphatase by Ca(2+)/calmodulin-dependent protein [corrected] kinase II.
  Journal
Mol Biol Cell 14:4003-14 (2003)
DOI:10.1091/mbc.E03-02-0061
Reference
PMID:21338471
  Authors
Tornquist K
  Title
Sphingosine 1-phosphate, sphingosine kinase and autocrine calcium signalling in thyroid cells.
  Journal
Acta Physiol (Oxf) 204:151-7 (2012)
DOI:10.1111/j.1748-1716.2011.02265.x
Reference
PMID:22129055
  Authors
Feske S
  Title
Immunodeficiency due to defects in store-operated calcium entry.
  Journal
Ann N Y Acad Sci 1238:74-90 (2011)
DOI:10.1111/j.1749-6632.2011.06240.x
Reference
PMID:22002090
  Authors
Giachini FR, Lima VV, Hannan JL, Carneiro FS, Webb RC, Tostes RC
  Title
STIM1/Orai1-mediated store-operated Ca2+ entry: the tip of the iceberg.
  Journal
Braz J Med Biol Res 44:1080-7 (2011)
DOI:10.1590/S0100-879X2011007500133
Reference
PMID:19172794
  Authors
Baba Y, Kurosaki T
  Title
[Regulation of store-operated calcium entry by STIM1].
  Journal
Seikagaku 80:1123-8 (2008)
Reference
PMID:19475418
  Authors
Galione A, Evans AM, Ma J, Parrington J, Arredouani A, Cheng X, Zhu MX
  Title
The acid test: the discovery of two-pore channels (TPCs) as NAADP-gated endolysosomal Ca(2+) release channels.
  Journal
Pflugers Arch 458:869-76 (2009)
DOI:10.1007/s00424-009-0682-y
Reference
PMID:19434403
  Authors
Beard NA, Wei L, Dulhunty AF
  Title
Ca(2+) signaling in striated muscle: the elusive roles of triadin, junctin, and calsequestrin.
  Journal
Eur Biophys J 39:27-36 (2009)
DOI:10.1007/s00249-009-0449-6
Reference
PMID:26228554
  Authors
Marty I
  Title
Triadin regulation of the ryanodine receptor complex.
  Journal
J Physiol 593:3261-6 (2015)
DOI:10.1113/jphysiol.2014.281147
Reference
PMID:20807542
  Authors
Arvanitis DA, Vafiadaki E, Sanoudou D, Kranias EG
  Title
Histidine-rich calcium binding protein: the new regulator of sarcoplasmic reticulum calcium cycling.
  Journal
J Mol Cell Cardiol 50:43-9 (2011)
DOI:10.1016/j.yjmcc.2010.08.021
Related
pathway
tge04010  MAPK signaling pathway
tge04070  Phosphatidylinositol signaling system
tge04210  Apoptosis
tge04720  Long-term potentiation
tge04730  Long-term depression
KO pathway
ko04020   

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