KEGG   PATHWAY: bbub04810
Entry
bbub04810                   Pathway                                
Name
Regulation of actin cytoskeleton - Bubalus bubalis (water buffalo)
Class
Cellular Processes; Cell motility
Pathway map
bbub04810  Regulation of actin cytoskeleton
bbub04810

Other DBs
GO: 0030036
Organism
Bubalus bubalis (water buffalo) [GN:bbub]
Gene
102388942  ARPC4; actin-related protein 2/3 complex subunit 4 isoform X2 [KO:K05755]
102389136  PTK2; focal adhesion kinase 1 isoform X16 [KO:K05725] [EC:2.7.10.2]
102389483  CRKL; crk-like protein [KO:K04438]
102389830  MRAS; LOW QUALITY PROTEIN: ras-related protein M-Ras [KO:K07831]
102390064  [KO:K05757]
102390212  GNA13; LOW QUALITY PROTEIN: guanine nucleotide-binding protein subunit alpha-13 [KO:K04639]
102390226  [KO:K12757]
102390332  ITGA3; integrin alpha-3 isoform X1 [KO:K06482]
102390579  MYL10; myosin regulatory light chain 10 isoform X1 [KO:K12756]
102390609  MYL9; myosin regulatory light polypeptide 9 [KO:K12755]
102391021  AKT3; RAC-gamma serine/threonine-protein kinase isoform X4 [KO:K04456] [EC:2.7.11.1]
102391225  PAK3; serine/threonine-protein kinase PAK 3 isoform X4 [KO:K05733] [EC:2.7.11.1]
102391335  ITGB3; integrin beta-3 isoform X1 [KO:K06493]
102391421  LIMK1; LIM domain kinase 1 isoform X1 [KO:K05743] [EC:2.7.11.1]
102391781  BCAR1; breast cancer anti-estrogen resistance protein 1 isoform X4 [KO:K05726]
102391879  PIP5K1A; phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X5 [KO:K00889] [EC:2.7.1.68]
102391982  DIAPH3; protein diaphanous homolog 3 isoform X2 [KO:K05745]
102391983  FGF10; fibroblast growth factor 10 [KO:K04358]
102392076  CHRM5; muscarinic acetylcholine receptor M5 [KO:K04133]
102392089  FGF20; fibroblast growth factor 20 isoform X2 [KO:K04358]
102392216  PDGFRB; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
102392462  SSH1; protein phosphatase Slingshot homolog 1 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
102392559  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
102392849  PDGFC; platelet-derived growth factor C isoform X3 [KO:K05450]
102392863  ARAF; serine/threonine-protein kinase A-Raf isoform X2 [KO:K08845] [EC:2.7.11.1]
102392913  SOS1; son of sevenless homolog 1 isoform X3 [KO:K03099]
102392995  KRAS; GTPase KRas isoform X2 [KO:K07827]
102393123  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
102393179  FGF1; fibroblast growth factor 1 isoform X1 [KO:K18496]
102393273  FGF2; fibroblast growth factor 2 [KO:K18497]
102393591  RAC2; ras-related C3 botulinum toxin substrate 2 isoform X1 [KO:K07860]
102393671  WASF1; wiskott-Aldrich syndrome protein family member 1 isoform X4 [KO:K05753]
102393702  BDKRB2; B2 bradykinin receptor [KO:K03916]
102393886  ITGA11; integrin alpha-11 [KO:K06587]
102393959  ACTG1; actin, cytoplasmic 2 [KO:K05692]
102393988  MYL2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform isoform X1 [KO:K10351]
102394030  BDKRB1; B1 bradykinin receptor [KO:K03915]
102394323  CXCR4; C-X-C chemokine receptor type 4 [KO:K04189]
102394511  [KO:K06594]
102394633  FGF21; fibroblast growth factor 21 [KO:K22429]
102395065  PFN4; profilin-4 [KO:K05759]
102395084  PPP1R12A; protein phosphatase 1 regulatory subunit 12A isoform X1 [KO:K06270]
102395168  ITGB6; integrin beta-6 isoform X1 [KO:K06589]
102395214  MYLK3; myosin light chain kinase 3 isoform X4 [KO:K00907] [EC:2.7.11.18]
102395266  PPP1CA; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
102395384  [KO:K02649]
102395462  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
102395516  CFL1; cofilin-1 [KO:K05765]
102395549  ITGA10; integrin alpha-10 isoform X1 [KO:K06586]
102395591  ITGAX; integrin alpha-X isoform X2 [KO:K06462]
102395717  RRAS2; ras-related protein R-Ras2 isoform X1 [KO:K07830]
102395809  FGF9; fibroblast growth factor 9 isoform X2 [KO:K04358]
102395856  ARHGEF4; rho guanine nucleotide exchange factor 4 isoform X1 [KO:K05769]
102396036  IQGAP2; ras GTPase-activating-like protein IQGAP2 [KO:K05767]
102396110  ITGB7; integrin beta-7 isoform X2 [KO:K06590]
102396193  GNG14; LOW QUALITY PROTEIN: putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347]
102396206  MAPK1; mitogen-activated protein kinase 1 isoform X1 [KO:K04371] [EC:2.7.11.24]
102396222  ARPC5; actin-related protein 2/3 complex subunit 5 [KO:K05754]
102396256  CYFIP2; cytoplasmic FMR1-interacting protein 2 isoform X1 [KO:K05749]
102396436  INS; insulin [KO:K04526]
102396526  [KO:K06461]
102396758  ABI2; abl interactor 2 isoform X1 [KO:K05751]
102396799  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
102396842  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
102396874  APC; adenomatous polyposis coli protein isoform X1 [KO:K02085]
102396897  C8G; complement component C8 gamma chain isoform X1 [KO:K03999]
102396900  MYH10; myosin-10 isoform X1 [KO:K10352]
102396940  PDGFB; platelet-derived growth factor subunit B isoform X1 [KO:K17386]
102397411  CRK; adapter molecule crk isoform X1 [KO:K04438]
102397446  ARHGEF12; rho guanine nucleotide exchange factor 12 isoform X2 [KO:K07532]
102397491  PXN; paxillin isoform X2 [KO:K05760]
102397554  ARPC1B; actin-related protein 2/3 complex subunit 1B [KO:K05757]
102397556  C9; complement component C9 [KO:K04000]
102397640  MOS; proto-oncogene serine/threonine-protein kinase mos [KO:K04367] [EC:2.7.11.1]
102397868  ARPC1A; actin-related protein 2/3 complex subunit 1A [KO:K05757]
102397912  ARHGEF6; rho guanine nucleotide exchange factor 6 isoform X7 [KO:K05729]
102397913  ACTR3B; actin-related protein 3B isoform X1 [KO:K18584]
102397941  CFL2; cofilin-2 [KO:K05765]
102397947  IQGAP1; ras GTPase-activating-like protein IQGAP1 [KO:K16848]
102397969  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
102398103  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
102398108  MYL7; myosin regulatory light chain 2, atrial isoform [KO:K12754]
102398160  RRAS; ras-related protein R-Ras [KO:K07829]
102398292  CYRIB; CYFIP-related Rac1 interactor B isoform X1 [KO:K27976]
102398426  PIP5K1C; phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform X5 [KO:K00889] [EC:2.7.1.68]
102398687  ITGB5; integrin beta-5 [KO:K06588]
102398761  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
102398762  PIP5K1B; phosphatidylinositol 4-phosphate 5-kinase type-1 beta isoform X2 [KO:K00889] [EC:2.7.1.68]
102398804  ROCK1; rho-associated protein kinase 1 isoform X2 [KO:K04514] [EC:2.7.11.39]
102399196  FGD3; FYVE, RhoGEF and PH domain-containing protein 3 isoform X4 [KO:K05722]
102399225  [KO:K07829]
102399487  NRAS; GTPase NRas isoform X2 [KO:K07828]
102400042  ITGB4; integrin beta-4 isoform X1 [KO:K06525]
102400118  CYFIP1; LOW QUALITY PROTEIN: cytoplasmic FMR1-interacting protein 1 [KO:K05749]
102400120  ITGB2; integrin beta-2 isoform X1 [KO:K06464]
102400173  RDX; radixin isoform X2 [KO:K05762]
102400211  PIP4K2A; phosphatidylinositol 5-phosphate 4-kinase type-2 alpha [KO:K00920] [EC:2.7.1.149]
102400238  CHRM3; muscarinic acetylcholine receptor M3 isoform X1 [KO:K04131]
102400272  FGF16; fibroblast growth factor 16 [KO:K04358]
102400287  [KO:K12757]
102400361  PFN2; profilin-2 isoform X2 [KO:K05759]
102400377  FGF3; fibroblast growth factor 3 [KO:K04358]
102400518  C5; complement C5 [KO:K03994]
102400519  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
102400520  [KO:K05764]
102400540  ITGAE; integrin alpha-E [KO:K06524]
102400689  FGF4; fibroblast growth factor 4 [KO:K04358]
102400705  MSN; moesin [KO:K05763]
102400830  [KO:K12757]
102401079  BRAF; serine/threonine-protein kinase B-raf isoform X2 [KO:K04365] [EC:2.7.11.1]
102401103  ITGA2B; integrin alpha-IIb isoform X1 [KO:K06476]
102401176  ITGA9; integrin alpha-9 isoform X1 [KO:K06585]
102401423  ITGB1; integrin beta-1 isoform X1 [KO:K05719]
102401446  FGF5; fibroblast growth factor 5 isoform X1 [KO:K04358]
102401645  NCKAP1L; nck-associated protein 1-like [KO:K05750]
102401695  [KO:K05719]
102401744  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369] [EC:2.7.12.2]
102401949  ARHGEF1; rho guanine nucleotide exchange factor 1 isoform X6 [KO:K12330]
102402025  RHOA; transforming protein RhoA [KO:K04513]
102402236  INSRR; insulin receptor-related protein [KO:K05086] [EC:2.7.10.1]
102402259  ACTN1; alpha-actinin-1 isoform X1 [KO:K05699]
102402316  ARPC2; actin-related protein 2/3 complex subunit 2 [KO:K05758]
102402448  RGCC; regulator of cell cycle RGCC isoform X2 [KO:K26108]
102402640  C8A; complement component C8 alpha chain [KO:K03997]
102402670  PAK2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
102402767  ACTR2; actin-related protein 2 isoform X1 [KO:K17260]
102402899  MYLK; myosin light chain kinase, smooth muscle isoform X2 [KO:K00907] [EC:2.7.11.18]
102402932  FGFR2; fibroblast growth factor receptor 2 isoform X12 [KO:K05093] [EC:2.7.10.1]
102402963  C8B; complement component C8 beta chain isoform X1 [KO:K03998]
102403100  SCIN; adseverin isoform X1 [KO:K05768]
102403111  SLC9A1; sodium/hydrogen exchanger 1 [KO:K05742]
102403192  PAK4; serine/threonine-protein kinase PAK 4 isoform X1 [KO:K05734] [EC:2.7.11.1]
102403296  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
102403436  ENAH; protein enabled homolog isoform X2 [KO:K05746]
102403472  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
102403593  PPP1R12C; protein phosphatase 1 regulatory subunit 12C [KO:K17457]
102403648  GSN; gelsolin isoform X1 [KO:K05768]
102403710  ARHGAP35; rho GTPase-activating protein 35 isoform X1 [KO:K05732]
102403867  FGF7; fibroblast growth factor 7 isoform X1 [KO:K04358]
102403960  CXCL12; stromal cell-derived factor 1 isoform X1 [KO:K10031]
102404165  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
102404517  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta isoform X1 [KO:K02649]
102404538  ITGA5; integrin alpha-5 [KO:K06484]
102404610  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
102404884  FGD1; FYVE, RhoGEF and PH domain-containing protein 1 [KO:K05720]
102405463  ITGA4; integrin alpha-4 isoform X3 [KO:K06483]
102405805  MYH11; myosin-11 isoform X1 [KO:K10352]
102405935  WASF2; wiskott-Aldrich syndrome protein family member 2 [KO:K05748]
102406026  VCL; vinculin isoform X1 [KO:K05700]
102406108  LPAR1; lysophosphatidic acid receptor 1 isoform X1 [KO:K04289]
102406228  LIMK2; LIM domain kinase 2 isoform X1 [KO:K05744] [EC:2.7.11.1]
102406242  ITGA7; integrin alpha-7 isoform X6 [KO:K06583]
102406315  ITGAV; integrin alpha-V isoform X2 [KO:K06487]
102406385  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
102407018  PIP4K2C; phosphatidylinositol 5-phosphate 4-kinase type-2 gamma isoform X1 [KO:K00920] [EC:2.7.1.149]
102407059  LPAR5; lysophosphatidic acid receptor 5 [KO:K08390]
102407288  FGFR1; fibroblast growth factor receptor 1 isoform X7 [KO:K04362] [EC:2.7.10.1]
102407346  VAV2; guanine nucleotide exchange factor VAV2 isoform X4 [KO:K05730]
102407393  F2R; proteinase-activated receptor 1 [KO:K03914]
102407513  [KO:K05759]
102407728  FGF22; fibroblast growth factor 22 isoform X1 [KO:K04358]
102407948  NCKAP1; nck-associated protein 1 isoform X1 [KO:K05750]
102408091  KNG1; kininogen-1 isoform X3 [KO:K03898]
102408400  C7; complement component C7 [KO:K03996]
102408521  TMSB4X; thymosin beta-4 [KO:K05764]
102408738  C6; complement component C6 [KO:K03995]
102408927  SSH3; protein phosphatase Slingshot homolog 3 isoform X1 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
102408993  CHRM4; muscarinic acetylcholine receptor M4 [KO:K04132]
102409021  FGF6; fibroblast growth factor 6 [KO:K04358]
102409062  PPP1R12B; protein phosphatase 1 regulatory subunit 12B isoform X5 [KO:K12329]
102409224  ACTN4; alpha-actinin-4 isoform X1 [KO:K05699]
102409368  ROCK2; rho-associated protein kinase 2 isoform X4 [KO:K17388] [EC:2.7.11.39]
102409461  EZR; ezrin [KO:K08007]
102409475  FGF18; fibroblast growth factor 18 [KO:K04358]
102409620  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
102409650  GIT1; ARF GTPase-activating protein GIT1 isoform X3 [KO:K05737]
102409709  GNA12; guanine nucleotide-binding protein subunit alpha-12 isoform X2 [KO:K04346]
102410027  IQGAP3; ras GTPase-activating-like protein IQGAP3 isoform X1 [KO:K05767]
102410133  SRC; proto-oncogene tyrosine-protein kinase Src isoform X2 [KO:K05704] [EC:2.7.10.2]
102410593  FN1; fibronectin isoform X12 [KO:K05717]
102410725  MYH9; myosin-9 [KO:K10352]
102411002  PDGFD; platelet-derived growth factor D isoform X2 [KO:K05450]
102411165  LPAR2; lysophosphatidic acid receptor 2 [KO:K04291]
102411398  WASL; neural Wiskott-Aldrich syndrome protein isoform X2 [KO:K23612]
102411404  ITGA1; integrin alpha-1 [KO:K06480]
102411453  SPATA13; spermatogenesis-associated protein 13 isoform X1 [KO:K05769]
102411455  ITGB8; integrin beta-8 isoform X1 [KO:K06591]
102411583  DIAPH2; protein diaphanous homolog 2 isoform X4 [KO:K05741]
102411978  LPAR4; lysophosphatidic acid receptor 4 [KO:K04275]
102411996  BRK1; protein BRICK1 [KO:K05752]
102412001  CHRM2; muscarinic acetylcholine receptor M2 [KO:K04130]
102412068  ITGA2; integrin alpha-2 [KO:K06481]
102412230  VAV3; guanine nucleotide exchange factor VAV3 isoform X1 [KO:K05730]
102412285  DOCK1; dedicator of cytokinesis protein 1 isoform X1 [KO:K13708]
102412288  CHRM1; muscarinic acetylcholine receptor M1 [KO:K04129]
102412430  ITGAL; integrin alpha-L isoform X1 [KO:K05718]
102412646  MYLK4; myosin light chain kinase family member 4 isoform X2 [KO:K00907] [EC:2.7.11.18]
102412823  SOS2; son of sevenless homolog 2 [KO:K03099]
102412922  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
102413003  APC2; adenomatous polyposis coli protein 2 isoform X2 [KO:K02085]
102413018  TIAM1; rho guanine nucleotide exchange factor TIAM1 isoform X3 [KO:K05731]
102413025  FGFR4; fibroblast growth factor receptor 4 isoform X1 [KO:K05095] [EC:2.7.10.1]
102413075  PIKFYVE; 1-phosphatidylinositol 3-phosphate 5-kinase isoform X1 [KO:K00921] [EC:2.7.1.150]
102413106  [KO:K05764]
102413226  PIP4K2B; phosphatidylinositol 5-phosphate 4-kinase type-2 beta isoform X1 [KO:K00920] [EC:2.7.1.149]
102413358  ARHGEF7; rho guanine nucleotide exchange factor 7 isoform X2 [KO:K13710]
102413719  ACTB; actin, cytoplasmic 1 isoform X1 [KO:K05692]
102414124  PFN1; profilin-1 [KO:K05759]
102414262  PFN3; profilin-3 [KO:K05759]
102414520  PAK5; serine/threonine-protein kinase PAK 5 [KO:K05736] [EC:2.7.11.1]
102414815  DIAPH1; protein diaphanous homolog 1 isoform X1 [KO:K05740]
102414862  FGF19; fibroblast growth factor 19 [KO:K22603]
102414960  ACTR3; actin-related protein 3 [KO:K18584]
102415018  MYH14; myosin-14 isoform X1 [KO:K10352]
102415047  MYLK2; myosin light chain kinase 2, skeletal/cardiac muscle [KO:K00907] [EC:2.7.11.18]
102415109  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
102415273  F2; prothrombin isoform X2 [KO:K01313] [EC:3.4.21.5]
102415287  VAV1; proto-oncogene vav [KO:K05730]
102415315  MYLPF; myosin regulatory light chain 2, skeletal muscle isoform [KO:K12758]
102415407  ARPC5L; actin-related protein 2/3 complex subunit 5-like protein [KO:K05754]
102415482  SSH2; protein phosphatase Slingshot homolog 2 isoform X5 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
102415487  BAIAP2; brain-specific angiogenesis inhibitor 1-associated protein 2 isoform X2 [KO:K05627]
102415655  ITGA8; integrin alpha-8 isoform X1 [KO:K06584]
102415854  ITGA6; integrin alpha-6 isoform X1 [KO:K06485]
102416060  ARPC3; actin-related protein 2/3 complex subunit 3 [KO:K05756]
102416282  CYRIA; CYFIP-related Rac1 interactor A isoform X1 [KO:K27976]
102416325  EGF; LOW QUALITY PROTEIN: pro-epidermal growth factor [KO:K04357]
102416629  PAK6; serine/threonine-protein kinase PAK 6 [KO:K05735] [EC:2.7.11.1]
102416639  FGF8; fibroblast growth factor 8 [KO:K04358]
112577628  FGF17; fibroblast growth factor 17 isoform X1 [KO:K04358]
112578478  [KO:K05764]
112583827  [KO:K18584]
112587129  [KO:K02833]
123465581  [KO:K05756]
123465663  FGF23; fibroblast growth factor 23 [KO:K22428]
Compound
C00681  1-Acyl-sn-glycerol 3-phosphate
C01996  Acetylcholine
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11554  1-Phosphatidyl-1D-myo-inositol 3,4-bisphosphate
Reference
PMID:14744429
  Authors
Burridge K, Wennerberg K.
  Title
Rho and Rac take center stage.
  Journal
Cell 116:167-79 (2004)
DOI:10.1016/S0092-8674(04)00003-0
Reference
PMID:11082269
  Authors
Schmitz AA, Govek EE, Bottner B, Van Aelst L.
  Title
Rho GTPases: signaling, migration, and invasion.
  Journal
Exp Cell Res 261:1-12 (2000)
DOI:10.1006/excr.2000.5049
Reference
PMID:11152757
  Authors
Takai Y, Sasaki T, Matozaki T.
  Title
Small GTP-binding proteins.
  Journal
Physiol Rev 81:153-208 (2001)
DOI:10.1152/physrev.2001.81.1.153
Reference
PMID:12700767
  Authors
Pollard TD.
  Title
The cytoskeleton, cellular motility and the reductionist agenda.
  Journal
Nature 422:741-5 (2003)
DOI:10.1038/nature01598
Reference
PMID:14657486
  Authors
Ridley AJ, Schwartz MA, Burridge K, Firtel RA, Ginsberg MH, Borisy G, Parsons JT, Horwitz AR.
  Title
Cell migration: integrating signals from front to back.
  Journal
Science 302:1704-9 (2003)
DOI:10.1126/science.1092053
Reference
PMID:11082272
  Authors
Sastry SK, Burridge K.
  Title
Focal adhesions: a nexus for intracellular signaling and cytoskeletal dynamics.
  Journal
Exp Cell Res 261:25-36 (2000)
DOI:10.1006/excr.2000.5043
Reference
PMID:10574699
  Authors
Fukata M, Nakagawa M, Kuroda S, Kaibuchi K.
  Title
Cell adhesion and Rho small GTPases.
  Journal
J Cell Sci 112 ( Pt 24):4491-500 (1999)
Related
pathway
bbub04010  MAPK signaling pathway
bbub04510  Focal adhesion
bbub04520  Adherens junction
KO pathway
ko04810   

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