KEGG   PATHWAY: biu04810
Entry
biu04810                    Pathway                                
Name
Regulation of actin cytoskeleton - Bos indicus (zebu cattle)
Class
Cellular Processes; Cell motility
Pathway map
biu04810  Regulation of actin cytoskeleton
biu04810

Other DBs
GO: 0030036
Organism
Bos indicus (zebu cattle) [GN:biu]
Gene
109553009  DOCK1; dedicator of cytokinesis protein 1 [KO:K13708]
109553064  INSRR; insulin receptor-related protein [KO:K05086] [EC:2.7.10.1]
109553142  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
109553189  IQGAP3; ras GTPase-activating-like protein IQGAP3 isoform X1 [KO:K05767]
109553304  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
109553379  FGF20; fibroblast growth factor 20 [KO:K04358]
109553704  VCL; vinculin isoform X1 [KO:K05700]
109553743  CXCL12; stromal cell-derived factor 1 isoform X1 [KO:K10031]
109553948  CHRM3; muscarinic acetylcholine receptor M3 [KO:K04131]
109554150  FGF19; fibroblast growth factor 19 [KO:K22603]
109554256  [KO:K04358]
109554336  INS; insulin isoform X1 [KO:K04526]
109554414  PPP1CA; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
109554525  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
109554542  SSH3; protein phosphatase Slingshot homolog 3 isoform X1 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
109554636  CFL1; cofilin-1 isoform X1 [KO:K05765]
109554719  CHRM1; LOW QUALITY PROTEIN: muscarinic acetylcholine receptor M1 [KO:K04129]
109555027  ARAF; serine/threonine-protein kinase A-Raf isoform X1 [KO:K08845] [EC:2.7.11.1]
109555128  [KO:K05759]
109555129  PIP5K1A; phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X1 [KO:K00889] [EC:2.7.1.68]
109555160  DIAPH2; protein diaphanous homolog 2 [KO:K05741]
109555167  ARHGEF6; rho guanine nucleotide exchange factor 6 isoform X1 [KO:K05729]
109555193  MSN; moesin [KO:K05763]
109555310  TMSB4X; thymosin beta-4 [KO:K05764]
109555415  PAK3; serine/threonine-protein kinase PAK 3 [KO:K05733] [EC:2.7.11.1]
109555562  FGF16; fibroblast growth factor 16 [KO:K04358]
109555827  ITGA10; integrin alpha-10 isoform X1 [KO:K06586]
109555890  NRAS; GTPase NRas [KO:K07828]
109555956  ITGB5; integrin beta-5 [KO:K06588]
109556175  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
109556241  C8B; complement component C8 beta chain [KO:K03998]
109556242  C8A; complement component C8 alpha chain [KO:K03997]
109556345  [KO:K02649]
109556793  VAV3; guanine nucleotide exchange factor VAV3 [KO:K05730]
109557261  SCIN; adseverin [KO:K05768]
109557291  ITGB8; integrin beta-8 isoform X1 [KO:K06591]
109557585  WASL; neural Wiskott-Aldrich syndrome protein [KO:K23612]
109557673  CHRM2; muscarinic acetylcholine receptor M2 [KO:K04130]
109557698  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
109557815  ACTR3B; actin-related protein 3B isoform X1 [KO:K18584]
109557823  PIK3CA; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
109557859  [KO:K05768]
109557919  MYL7; myosin regulatory light chain 2, atrial isoform [KO:K12754]
109558343  ITGA5; integrin alpha-5 [KO:K06484]
109558630  [KO:K17386]
109558930  LPAR5; lysophosphatidic acid receptor 5 [KO:K08390]
109558936  PPP1R12A; protein phosphatase 1 regulatory subunit 12A isoform X1 [KO:K06270]
109559002  NCKAP1L; nck-associated protein 1-like [KO:K05750]
109559043  ITGB7; integrin beta-7 isoform X1 [KO:K06590]
109559290  PFN2; profilin-2 isoform X1 [KO:K05759]
109559318  PIP4K2C; phosphatidylinositol 5-phosphate 4-kinase type-2 gamma [KO:K00920] [EC:2.7.1.149]
109559400  ITGA7; integrin alpha-7 isoform X1 [KO:K06583]
109559517  MYH9; myosin-9 isoform X1 [KO:K10352]
109559531  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
109559581  KRAS; GTPase KRas isoform X1 [KO:K07827]
109559742  FGF6; fibroblast growth factor 6 [KO:K04358]
109559743  FGF23; fibroblast growth factor 23 [KO:K22428]
109559805  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
109559825  [KO:K17386]
109559860  MRAS; ras-related protein M-Ras [KO:K07831]
109559983  EGF; LOW QUALITY PROTEIN: pro-epidermal growth factor [KO:K04357]
109560475  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
109560724  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
109560786  ITGB2; integrin beta-2 [KO:K06464]
109560940  [KO:K02833]
109560955  VAV1; proto-oncogene vav [KO:K05730]
109561058  FGF22; fibroblast growth factor 22 [KO:K04358]
109561368  LPAR2; lysophosphatidic acid receptor 2 [KO:K04291]
109561418  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
109561546  [KO:K04347]
109561751  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
109561764  PIP5K1C; phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform X1 [KO:K00889] [EC:2.7.1.68]
109561893  FGFR4; fibroblast growth factor receptor 4 isoform X1 [KO:K05095] [EC:2.7.10.1]
109561903  PFN3; LOW QUALITY PROTEIN: profilin-3 [KO:K05759]
109561990  APC2; adenomatous polyposis coli protein 2 [KO:K02085]
109562052  TIAM1; T-lymphoma invasion and metastasis-inducing protein 1 [KO:K05731]
109562140  DIAPH1; LOW QUALITY PROTEIN: protein diaphanous homolog 1 [KO:K05740]
109562156  FGF1; fibroblast growth factor 1 isoform X1 [KO:K18496]
109562197  PDGFRB; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
109562251  CYFIP2; cytoplasmic FMR1-interacting protein 2 [KO:K05749]
109562486  PIP5K1B; phosphatidylinositol 4-phosphate 5-kinase type-1 beta [KO:K00889] [EC:2.7.1.68]
109562726  [KO:K03898]
109563260  FGD3; FYVE, RhoGEF and PH domain-containing protein 3 isoform X1 [KO:K05722]
109563336  LPAR1; lysophosphatidic acid receptor 1 [KO:K04289]
109563337  [KO:K04289]
109563409  C5; complement C5 [KO:K03994]
109563416  GSN; gelsolin isoform X1 [KO:K05768]
109563830  WASF1; wiskott-Aldrich syndrome protein family member 1 [KO:K05753]
109564088  EZR; ezrin [KO:K08007]
109564346  SOS2; son of sevenless homolog 2 [KO:K03099]
109564604  APC; adenomatous polyposis coli protein isoform X1 [KO:K02085]
109564647  IQGAP2; ras GTPase-activating-like protein IQGAP2 isoform X1 [KO:K05767]
109564649  F2R; proteinase-activated receptor 1 [KO:K03914]
109564697  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
109564717  ITGA11; integrin alpha-11 [KO:K06587]
109564896  CHRM5; muscarinic acetylcholine receptor M5 [KO:K04133]
109564925  PAK6; serine/threonine-protein kinase PAK 6 [KO:K05735] [EC:2.7.11.1]
109565018  CYFIP1; LOW QUALITY PROTEIN: cytoplasmic FMR1-interacting protein 1 [KO:K05749]
109565097  ARHGEF4; rho guanine nucleotide exchange factor 4 [KO:K05769]
109565142  FGF7; fibroblast growth factor 7 [KO:K04358]
109565282  ACTN1; alpha-actinin-1 isoform X1 [KO:K05699]
109565687  VAV2; LOW QUALITY PROTEIN: guanine nucleotide exchange factor VAV2 [KO:K05730]
109565743  ITGAV; integrin alpha-V [KO:K06487]
109565787  [KO:K05750]
109565881  ITGA4; integrin alpha-4 isoform X1 [KO:K06483]
109566002  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
109566217  ACTR2; actin-related protein 2 [KO:K17260]
109566263  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
109566339  PFN4; profilin-4 [KO:K05759]
109566367  FAM49A; protein FAM49A isoform X1 [KO:K27976]
109566382  ROCK2; rho-associated protein kinase 2 isoform X1 [KO:K17388] [EC:2.7.11.39]
109566462  ITGA6; integrin alpha-6 isoform X1 [KO:K06485]
109566463  ARPC5L; actin-related protein 2/3 complex subunit 5-like protein isoform X1 [KO:K05754]
109566624  C8G; complement component C8 gamma chain isoform X1 [KO:K03999]
109566663  DIAPH3; protein diaphanous homolog 3 [KO:K05745]
109566843  SPATA13; spermatogenesis-associated protein 13 isoform X1 [KO:K05769]
109566896  ARPC1B; actin-related protein 2/3 complex subunit 1B [KO:K05757]
109566977  RGCC; regulator of cell cycle RGCC [KO:K26108]
109567016  ARHGEF7; rho guanine nucleotide exchange factor 7 isoform X1 [KO:K13710]
109567047  FGF9; fibroblast growth factor 9 [KO:K04358]
109567207  ITGB6; integrin beta-6 isoform X1 [KO:K06589]
109567347  MYLK2; myosin light chain kinase 2, skeletal/cardiac muscle [KO:K00907] [EC:2.7.11.18]
109567416  MYL9; myosin regulatory light polypeptide 9 [KO:K12755]
109567428  SRC; proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
109567924  ITGB1; integrin beta-1 isoform X1 [KO:K05719]
109567940  PIP4K2A; phosphatidylinositol 5-phosphate 4-kinase type-2 alpha [KO:K00920] [EC:2.7.1.149]
109567943  PAK5; serine/threonine-protein kinase PAK 5 [KO:K05736] [EC:2.7.11.1]
109567974  ITGA8; integrin alpha-8 isoform X1 [KO:K06584]
109568167  CXCR4; C-X-C chemokine receptor type 4 [KO:K04189]
109568330  MOS; proto-oncogene serine/threonine-protein kinase mos [KO:K04367] [EC:2.7.11.1]
109568429  PTK2; LOW QUALITY PROTEIN: focal adhesion kinase 1 [KO:K05725] [EC:2.7.10.2]
109568436  ACTR3; actin-related protein 3 [KO:K18584]
109568521  FAM49B; protein FAM49B isoform X1 [KO:K27976]
109569536  ARHGEF12; rho guanine nucleotide exchange factor 12 isoform X1 [KO:K07532]
109569554  F2; prothrombin isoform X1 [KO:K01313] [EC:3.4.21.5]
109569566  RDX; radixin [KO:K05762]
109569760  ABI2; abl interactor 2 isoform X1 [KO:K05751]
109569777  RRAS2; ras-related protein R-Ras2 [KO:K07830]
109569805  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
109569900  CHRM4; muscarinic acetylcholine receptor M4 [KO:K04132]
109570267  PIKFYVE; 1-phosphatidylinositol 3-phosphate 5-kinase isoform X1 [KO:K00921] [EC:2.7.1.150]
109570286  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
109570415  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
109570451  ENAH; protein enabled homolog isoform X1 [KO:K05746]
109570492  ARPC2; actin-related protein 2/3 complex subunit 2 [KO:K05758]
109570879  FGF2; LOW QUALITY PROTEIN: fibroblast growth factor 2 [KO:K18497]
109570939  SSH1; protein phosphatase Slingshot homolog 1 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
109570973  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
109570977  CRKL; crk-like protein [KO:K04438]
109571069  PXN; paxillin isoform X1 [KO:K05760]
109571147  LIMK2; LIM domain kinase 2 isoform X1 [KO:K05744] [EC:2.7.11.1]
109571193  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
109571388  ARPC3; actin-related protein 2/3 complex subunit 3 [KO:K05756]
109571395  PDGFC; platelet-derived growth factor C isoform X1 [KO:K05450]
109571417  MYL2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
109571787  MYH14; myosin-14 [KO:K10352]
109571856  PPP1R12C; protein phosphatase 1 regulatory subunit 12C [KO:K17457]
109572074  FGF21; fibroblast growth factor 21 [KO:K22429]
109572222  RRAS; ras-related protein R-Ras [KO:K07829]
109572253  ARHGAP35; rho GTPase-activating protein 35 [KO:K05732]
109572496  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
109572506  ACTN4; alpha-actinin-4 isoform X1 [KO:K05699]
109572528  BCAR1; breast cancer anti-estrogen resistance protein 1 [KO:K05726]
109572727  MYLK3; myosin light chain kinase 3 isoform X1 [KO:K00907] [EC:2.7.11.18]
109572733  ARHGEF1; rho guanine nucleotide exchange factor 1 isoform X1 [KO:K12330]
109573135  WASF2; wiskott-Aldrich syndrome protein family member 2 [KO:K05748]
109573208  SLC9A1; sodium/hydrogen exchanger 1 [KO:K05742]
109573379  GNA13; guanine nucleotide-binding protein subunit alpha-13 [KO:K04639]
109573568  ITGA2B; integrin alpha-IIb [KO:K06476]
109573596  ITGAE; integrin alpha-E [KO:K06524]
109573630  SSH2; protein phosphatase Slingshot homolog 2 isoform X1 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
109573782  PFN1; profilin-1 [KO:K05759]
109573816  PIP4K2B; phosphatidylinositol 5-phosphate 4-kinase type-2 beta [KO:K00920] [EC:2.7.1.149]
109573824  BAIAP2; brain-specific angiogenesis inhibitor 1-associated protein 2 isoform X1 [KO:K05627]
109573847  CRK; adapter molecule crk isoform X1 [KO:K04438]
109573877  MYH10; myosin-10 isoform X1 [KO:K10352]
109573916  ACTG1; actin, cytoplasmic 2 [KO:K05692]
109574032  GIT1; ARF GTPase-activating protein GIT1 [KO:K05737]
109574049  ITGB4; integrin beta-4 isoform X1 [KO:K06525]
109574100  CDC42; cell division control protein 42 homolog [KO:K04393]
109574140  ITGB3; integrin beta-3 isoform X1 [KO:K06493]
109574210  ITGA3; integrin alpha-3 [KO:K06482]
109574290  RAC3; ras-related C3 botulinum toxin substrate 3 [KO:K07861]
109574799  ITGA1; integrin alpha-1 [KO:K06480]
109574805  PIK3R1; LOW QUALITY PROTEIN: phosphatidylinositol 3-kinase regulatory subunit alpha [KO:K02649]
109574862  ITGA2; integrin alpha-2 [KO:K06481]
109574935  C7; complement component C7 [KO:K03996]
109574958  C9; complement component C9 [KO:K04000]
109574981  C6; complement component C6 [KO:K03995]
109575026  FGF18; fibroblast growth factor 18 [KO:K04358]
109575035  [KO:K05750]
109575038  FGF10; fibroblast growth factor 10 [KO:K04358]
109575240  BDKRB1; B1 bradykinin receptor [KO:K03915]
109575386  IQGAP1; ras GTPase-activating-like protein IQGAP1 [KO:K16848]
109575418  CFL2; cofilin-2 [KO:K05765]
109575666  BDKRB2; B2 bradykinin receptor [KO:K03916]
109576048  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
109576053  RAF1; LOW QUALITY PROTEIN: RAF proto-oncogene serine/threonine-protein kinase [KO:K04366] [EC:2.7.11.1]
109576104  ARPC4; actin-related protein 2/3 complex subunit 4 [KO:K05755]
109576171  RHOA; transforming protein RhoA [KO:K04513]
109576217  ITGA9; integrin alpha-9 [KO:K06585]
109576249  BRK1; protein BRICK1 [KO:K05752]
109577322  MYLK4; myosin light chain kinase family member 4 isoform X1 [KO:K00907] [EC:2.7.11.18]
109577777  [KO:K12757]
109577779  [KO:K12757]
109577829  ROCK1; rho-associated protein kinase 1 isoform X1 [KO:K04514] [EC:2.7.11.39]
109578095  ARPC1A; actin-related protein 2/3 complex subunit 1A [KO:K05757]
109578145  ITGAL; integrin alpha-L [KO:K05718]
109578171  MYL10; myosin regulatory light chain 10 [KO:K12756]
109578192  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
109578204  GNA12; guanine nucleotide-binding protein subunit alpha-12 [KO:K04346]
109578288  MYH11; LOW QUALITY PROTEIN: myosin-11 [KO:K10352]
109578361  MYLPF; myosin regulatory light chain 2, skeletal muscle isoform [KO:K12758]
109578544  ACTB; actin, cytoplasmic 1 [KO:K05692]
109578611  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
109578667  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
109578799  [KO:K06594]
109579084  FGF8; fibroblast growth factor 8 [KO:K04358]
Compound
C00681  1-Acyl-sn-glycerol 3-phosphate
C01996  Acetylcholine
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11554  1-Phosphatidyl-1D-myo-inositol 3,4-bisphosphate
Reference
PMID:14744429
  Authors
Burridge K, Wennerberg K.
  Title
Rho and Rac take center stage.
  Journal
Cell 116:167-79 (2004)
DOI:10.1016/S0092-8674(04)00003-0
Reference
PMID:11082269
  Authors
Schmitz AA, Govek EE, Bottner B, Van Aelst L.
  Title
Rho GTPases: signaling, migration, and invasion.
  Journal
Exp Cell Res 261:1-12 (2000)
DOI:10.1006/excr.2000.5049
Reference
PMID:11152757
  Authors
Takai Y, Sasaki T, Matozaki T.
  Title
Small GTP-binding proteins.
  Journal
Physiol Rev 81:153-208 (2001)
DOI:10.1152/physrev.2001.81.1.153
Reference
PMID:12700767
  Authors
Pollard TD.
  Title
The cytoskeleton, cellular motility and the reductionist agenda.
  Journal
Nature 422:741-5 (2003)
DOI:10.1038/nature01598
Reference
PMID:14657486
  Authors
Ridley AJ, Schwartz MA, Burridge K, Firtel RA, Ginsberg MH, Borisy G, Parsons JT, Horwitz AR.
  Title
Cell migration: integrating signals from front to back.
  Journal
Science 302:1704-9 (2003)
DOI:10.1126/science.1092053
Reference
PMID:11082272
  Authors
Sastry SK, Burridge K.
  Title
Focal adhesions: a nexus for intracellular signaling and cytoskeletal dynamics.
  Journal
Exp Cell Res 261:25-36 (2000)
DOI:10.1006/excr.2000.5043
Reference
PMID:10574699
  Authors
Fukata M, Nakagawa M, Kuroda S, Kaibuchi K.
  Title
Cell adhesion and Rho small GTPases.
  Journal
J Cell Sci 112 ( Pt 24):4491-500 (1999)
Related
pathway
biu04010  MAPK signaling pathway
biu04510  Focal adhesion
biu04520  Adherens junction
KO pathway
ko04810   

DBGET integrated database retrieval system