KEGG   PATHWAY: btax05168
Entry
btax05168                   Pathway                                
Name
Herpes simplex virus 1 infection - Budorcas taxicolor (takin)
Description
Herpes simplex virus 1(HSV-1) is a common human pathogen, which initially infects orofacial mucosal surfaces. The virus replicates in epithelial cells at these sites, causing clinically overt disease characterized by vesicular lesions. HSV-1 then penetrates to the nervous system and establishes latency in sensory neurons. Throughout the lifetime of the host, HSV-1 may reactivate from its latent state and reinitiate a lytic infection cycle. HSV-1 has developed various mechanisms to escape its host innate immune responses and increased its capacity to replicate and to persist. ICP34.5, ICP0, ICP27, Us11 and Vhs (UL41) are the proteins involved in viral interference.
Class
Human Diseases; Infectious disease: viral
Pathway map
btax05168  Herpes simplex virus 1 infection
btax05168

Disease
H00365  Herpes simplex virus infection
Organism
Budorcas taxicolor (takin) [GN:btax]
Gene
128043437  IFIH1; interferon-induced helicase C domain-containing protein 1 [KO:K12647] [EC:5.6.2.6]
128043660  [KO:K15411]
128043673  PILRA; paired immunoglobulin-like type 2 receptor alpha [KO:K15411]
128043920  TSC2; tuberin isoform X1 [KO:K07207]
128044048  IFNAR1; interferon alpha/beta receptor 1 [KO:K05130]
128044474  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
128044694  POU2F1; POU domain, class 2, transcription factor 1 [KO:K09364]
128044816  JAK1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
128045385  EIF2B3; translation initiation factor eIF-2B subunit gamma [KO:K03241]
128045803  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
128046227  [KO:K08738]
128046520  RHEB; GTP-binding protein Rheb [KO:K07208]
128046813  ZC3HAV1; zinc finger CCCH-type antiviral protein 1 [KO:K28004]
128046952  IL6; interleukin-6 [KO:K05405]
128047300  STAT2; signal transducer and activator of transcription 2 isoform X1 [KO:K11221]
128047334  IFNGR2; interferon gamma receptor 2 [KO:K05133]
128047410  TAPBPL; tapasin-related protein isoform X1 [KO:K28445]
128047668  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A isoform X1 [KO:K03158]
128047841  TBK1; serine/threonine-protein kinase TBK1 [KO:K05410] [EC:2.7.11.10]
128047923  BID; BH3-interacting domain death agonist [KO:K04726]
128048021  APAF1; apoptotic protease-activating factor 1 [KO:K02084]
128048026  HCFC2; host cell factor 2 [KO:K27390]
128048083  TLR9; toll-like receptor 9 [KO:K10161]
128048506  IFNG; interferon gamma [KO:K04687]
128048533  IRAK4; interleukin-1 receptor-associated kinase 4 [KO:K04733] [EC:2.7.11.1]
128048841  ITGA5; integrin alpha-5 isoform X1 [KO:K06484]
128049014  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 [KO:K04403]
128049046  MYD88; myeloid differentiation primary response protein MyD88 [KO:K04729]
128049417  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
128049822  [KO:K04451]
128050274  STING1; stimulator of interferon genes protein [KO:K12654]
128050301  TYK2; non-receptor tyrosine-protein kinase TYK2 isoform X1 [KO:K11219] [EC:2.7.10.2]
128050332  [KO:K03990]
128050333  [KO:K03990]
128050368  IL12A; interleukin-12 subunit alpha isoform X1 [KO:K05406]
128050402  [KO:K06731]
128050403  [KO:K06731]
128050540  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
128050916  TICAM1; TIR domain-containing adapter molecule 1 [KO:K05842]
128050932  CALR; calreticulin [KO:K08057]
128050939  CD74; HLA class II histocompatibility antigen gamma chain isoform X1 [KO:K06505]
128050979  [KO:K06751]
128051514  IL12B; interleukin-12 subunit beta [KO:K05425]
128051638  [KO:K05477]
128051673  [KO:K06731]
128051762  [KO:K03174]
128052316  JAK2; tyrosine-protein kinase JAK2 [KO:K04447] [EC:2.7.10.2]
128052363  EIF2B5; translation initiation factor eIF-2B subunit epsilon [KO:K03240]
128052376  SYK; tyrosine-protein kinase SYK [KO:K05855] [EC:2.7.10.2]
128052429  [KO:K05414]
128052430  [KO:K05414]
128052431  [KO:K05414]
128052432  [KO:K05414]
128052433  [KO:K05414]
128052459  [KO:K05414]
128052476  [KO:K05414]
128052481  RIGI; antiviral innate immune response receptor RIG-I [KO:K12646] [EC:5.6.2.6]
128052536  C5; complement C5 [KO:K03994]
128052625  [KO:K05415]
128052626  [KO:K05415]
128052627  [KO:K05415]
128052628  [KO:K05415]
128052635  [KO:K05415]
128052636  [KO:K05415]
128052637  [KO:K05415]
128052638  [KO:K05415]
128052639  [KO:K05415]
128052640  [KO:K05415]
128052652  [KO:K05415]
128052682  [KO:K05414]
128052694  [KO:K05414]
128052696  [KO:K05414]
128052697  [KO:K05414]
128052706  [KO:K05414]
128053126  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 [KO:K04404]
128053252  MAP3K7; mitogen-activated protein kinase kinase kinase 7 [KO:K04427] [EC:2.7.11.25]
128053263  IFNGR1; interferon gamma receptor 1 isoform X1 [KO:K05132]
128053541  CGAS; cyclic GMP-AMP synthase [KO:K17834] [EC:2.7.7.86]
128053792  SRSF5; serine/arginine-rich splicing factor 5 [KO:K12893]
128053799  [KO:K08055]
128053800  [KO:K08055]
128053843  [KO:K08738]
128053924  [KO:K08738]
128054019  [KO:K08738]
128054117  EIF2S1; eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
128054132  EIF2B2; translation initiation factor eIF-2B subunit beta [KO:K03754]
128054182  IRF9; interferon regulatory factor 9 isoform X1 [KO:K04693]
128055125  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
128055142  SRSF3; serine/arginine-rich splicing factor 3 [KO:K12892]
128055236  [KO:K06751]
128055280  [KO:K06751]
128055281  [KO:K06751]
128055305  [KO:K06751]
128055329  [KO:K06752]
128055330  [KO:K06752]
128055331  [KO:K06752]
128055332  [KO:K06752]
128055370  [KO:K06752]
128055475  TRAF2; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
128055500  [KO:K05131]
128055504  EIF2B4; translation initiation factor eIF-2B subunit delta isoform X1 [KO:K03680]
128055526  DAXX; death domain-associated protein 6 isoform X1 [KO:K02308]
128055536  TAPBP; tapasin [KO:K08058]
128055541  [KO:K06752]
128055605  [KO:K06752]
128055814  [KO:K06752]
128056011  [KO:K06752]
128056013  SRSF7; serine/arginine-rich splicing factor 7 isoform X1 [KO:K12896]
128056049  TAP2; antigen peptide transporter 2 [KO:K05654] [EC:7.4.2.14]
128056082  BAK1; bcl-2 homologous antagonist/killer isoform X1 [KO:K14021]
128056161  TAP1; antigen peptide transporter 1 [KO:K05653] [EC:7.4.2.14]
128056359  [KO:K06752]
128056391  SRPK1; LOW QUALITY PROTEIN: SRSF protein kinase 1 [KO:K15409] [EC:2.7.11.1]
128056564  [KO:K06752]
128056569  IL1B; interleukin-1 beta [KO:K04519]
128056628  CARD9; caspase recruitment domain-containing protein 9 [KO:K12794]
128056632  TSC1; hamartin isoform X1 [KO:K07206]
128056652  [KO:K06752]
128056687  EIF2AK2; interferon-induced, double-stranded RNA-activated protein kinase [KO:K16195] [EC:2.7.11.1]
128056772  TNF; tumor necrosis factor [KO:K03156]
128056806  [KO:K06752]
128056812  [KO:K06752]
128056921  LTA; lymphotoxin-alpha [KO:K05468]
128057999  MAVS; mitochondrial antiviral-signaling protein isoform X1 [KO:K12648]
128058174  SRC; proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
128058199  SRSF6; serine/arginine-rich splicing factor 6 [KO:K12893]
128058470  BCL2L1; bcl-2-like protein 1 [KO:K04570]
128059210  [KO:K04570]
128059988  [KO:K07205]
128060118  BIRC2; LOW QUALITY PROTEIN: baculoviral IAP repeat-containing protein 2 [KO:K16060]
128060227  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
128060491  BIRC3; baculoviral IAP repeat-containing protein 3 [KO:K16060]
128060869  NECTIN1; nectin-1 [KO:K06081]
128060876  POU2F3; POU domain, class 2, transcription factor 3 [KO:K09364]
128061236  [KO:K15413]
128061241  CASP9; caspase-9 [KO:K04399] [EC:3.4.22.62]
128061243  [KO:K15413]
128061491  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
128061515  [KO:K07293] [EC:3.1.3.48]
128061603  IKBKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon [KO:K07211] [EC:2.7.11.10]
128061687  MTOR; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
128061711  TRAF5; TNF receptor-associated factor 5 [KO:K09849]
128061812  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
128061813  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
128061820  RNASEL; 2-5A-dependent ribonuclease [KO:K01165]
128062064  PTPN11; tyrosine-protein phosphatase non-receptor type 11 isoform X1 [KO:K07293] [EC:3.1.3.48]
128062102  OAS2; LOW QUALITY PROTEIN: 2'-5'-oligoadenylate synthase 2 [KO:K14216] [EC:2.7.7.84]
128062104  [KO:K14216] [EC:2.7.7.84]
128062181  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
128062267  EIF2B1; translation initiation factor eIF-2B subunit alpha [KO:K03239]
128062315  SRSF9; serine/arginine-rich splicing factor 9 [KO:K21123]
128062341  OAS1; 2'-5'-oligoadenylate synthase 1 [KO:K14216] [EC:2.7.7.84]
128062381  [KO:K14216] [EC:2.7.7.84]
128062410  TLR2; toll-like receptor 2 [KO:K10159]
128062626  SRSF4; serine/arginine-rich splicing factor 4 isoform X1 [KO:K12893]
128062922  IRF3; interferon regulatory factor 3 isoform X1 [KO:K05411]
128063092  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
128063158  POU2F2; POU domain, class 2, transcription factor 2 [KO:K09364]
128063214  NECTIN2; nectin-2 isoform X1 [KO:K06531]
128063870  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
128064207  BAX; apoptosis regulator BAX [KO:K02159]
128064531  ALYREF; THO complex subunit 4 [KO:K12881]
128064554  SRSF1; LOW QUALITY PROTEIN: serine/arginine-rich splicing factor 1 [KO:K12890]
128064672  TP53; cellular tumor antigen p53 [KO:K04451]
128064715  SOCS3; suppressor of cytokine signaling 3 [KO:K04696]
128064775  CASP8; caspase-8 [KO:K04398] [EC:3.4.22.61]
128064805  [KO:K12499]
128064875  ITGB3; integrin beta-3 [KO:K06493]
128065036  SRSF2; serine/arginine-rich splicing factor 2 [KO:K12891]
128065365  [KO:K14624]
128066235  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha [KO:K02649]
128066395  PML; protein PML isoform X1 [KO:K10054] [EC:2.3.2.-]
128066552  PDIA3; protein disulfide-isomerase A3 [KO:K08056] [EC:5.3.4.1]
128066643  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
128066664  TRAF3; TNF receptor-associated factor 3 [KO:K03174]
128067048  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
128067358  BCL2; apoptosis regulator Bcl-2 isoform X1 [KO:K02161]
128067677  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
128067871  FAS; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
128068203  EIF4EBP1; eukaryotic translation initiation factor 4E-binding protein 1 isoform X1 [KO:K07205]
128068238  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
128068336  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
128068349  TLR3; toll-like receptor 3 [KO:K05401]
128068503  PPP1CA; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
128068546  RELA; transcription factor p65 [KO:K04735]
128068641  FADD; FAS-associated death domain protein [KO:K02373]
128068699  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
128068703  IRF7; interferon regulatory factor 7 [KO:K09447]
128068977  BAD; bcl2-associated agonist of cell death [KO:K02158]
128069052  NXF1; nuclear RNA export factor 1 [KO:K14284]
128069489  [KO:K08738]
128069805  IRAK1; interleukin-1 receptor-associated kinase 1 [KO:K04730] [EC:2.7.11.1]
128069947  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
128070114  [KO:K14284]
128070145  [KO:K14284]
128070146  [KO:K14284]
128070461  NXF3; LOW QUALITY PROTEIN: nuclear RNA export factor 3 [KO:K14284]
128070469  CFP; properdin [KO:K15412]
128070556  HCFC1; host cell factor 1 isoform X1 [KO:K14966]
128071221  STAT1; signal transducer and activator of transcription 1-alpha/beta [KO:K11220]
128071419  [KO:K06505]
Compound
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C20640  Cyclic GMP-AMP
C20935  2-5A
Reference
PMID:12787566
  Authors
Granger SW, Rickert S
  Title
LIGHT-HVEM signaling and the regulation of T cell-mediated immunity.
  Journal
Cytokine Growth Factor Rev 14:289-96 (2003)
DOI:10.1016/S1359-6101(03)00031-5
Reference
PMID:19495760
  Authors
Steinberg MW, Shui JW, Ware CF, Kronenberg M
  Title
Regulating the mucosal immune system: the contrasting roles of LIGHT, HVEM, and their various partners.
  Journal
Semin Immunopathol 31:207-21 (2009)
DOI:10.1007/s00281-009-0157-4
Reference
PMID:20221426
  Authors
MacLeod IJ, Minson T
  Title
Binding of herpes simplex virus type-1 virions leads to the induction of intracellular signalling in the absence of virus entry.
  Journal
PLoS One 5:e9560 (2010)
DOI:10.1371/journal.pone.0009560
Reference
PMID:23150579
  Authors
Gianni T, Leoni V, Chesnokova LS, Hutt-Fletcher LM, Campadelli-Fiume G
  Title
alphavbeta3-integrin is a major sensor and activator of innate immunity to herpes simplex virus-1.
  Journal
Proc Natl Acad Sci U S A 109:19792-7 (2012)
DOI:10.1073/pnas.1212597109
Reference
PMID:25375272
  Authors
Gianni T, Campadelli-Fiume G
  Title
The epithelial alphavbeta3-integrin boosts the MYD88-dependent TLR2 signaling in response to viral and bacterial components.
  Journal
PLoS Pathog 10:e1004477 (2014)
DOI:10.1371/journal.ppat.1004477
Reference
PMID:15056211
  Authors
Spear PG
  Title
Herpes simplex virus: receptors and ligands for cell entry.
  Journal
Cell Microbiol 6:401-10 (2004)
DOI:10.1111/j.1462-5822.2004.00389.x
Reference
PMID:12855695
  Authors
Boutell C, Everett RD
  Title
The herpes simplex virus type 1 (HSV-1) regulatory protein ICP0 interacts with and Ubiquitinates p53.
  Journal
J Biol Chem 278:36596-602 (2003)
DOI:10.1074/jbc.M300776200
Reference
PMID:24262390
  Authors
Ma Y, He B
  Title
Recognition of herpes simplex viruses: toll-like receptors and beyond.
  Journal
J Mol Biol 426:1133-47 (2014)
DOI:10.1016/j.jmb.2013.11.012
Reference
PMID:26952111
  Authors
Su C, Zhan G, Zheng C
  Title
Evasion of host antiviral innate immunity by HSV-1, an update.
  Journal
Virol J 13:38 (2016)
DOI:10.1186/s12985-016-0495-5
Reference
PMID:21994567
  Authors
Melchjorsen J, Matikainen S, Paludan SR
  Title
Activation and evasion of innate antiviral immunity by herpes simplex virus.
  Journal
Viruses 1:737-59 (2009)
DOI:10.3390/v1030737
Reference
PMID:15276609
  Authors
Morrison LA
  Title
The Toll of herpes simplex virus infection.
  Journal
Trends Microbiol 12:353-6 (2004)
DOI:10.1016/j.tim.2004.06.001
Reference
PMID:29298887
  Authors
Zheng C
  Title
Evasion of Cytosolic DNA-Stimulated Innate Immune Responses by Herpes Simplex Virus 1.
  Journal
J Virol 92:e00099-17 (2018)
DOI:10.1128/JVI.00099-17
Reference
PMID:19344302
  Authors
Grandi P, Peruzzi P, Reinhart B, Cohen JB, Chiocca EA, Glorioso JC
  Title
Design and application of oncolytic HSV vectors for glioblastoma therapy.
  Journal
Expert Rev Neurother 9:505-17 (2009)
DOI:10.1586/ern.09.9
Reference
PMID:23115300
  Authors
Lussignol M, Queval C, Bernet-Camard MF, Cotte-Laffitte J, Beau I, Codogno P, Esclatine A
  Title
The herpes simplex virus 1 Us11 protein inhibits autophagy through its interaction with the protein kinase PKR.
  Journal
J Virol 87:859-71 (2013)
DOI:10.1128/JVI.01158-12
Reference
PMID:17229694
  Authors
Sanchez R, Mohr I
  Title
Inhibition of cellular 2'-5' oligoadenylate synthetase by the herpes simplex virus type 1 Us11 protein.
  Journal
J Virol 81:3455-64 (2007)
DOI:10.1128/JVI.02520-06
Reference
PMID:12826401
  Authors
Wysocka J, Herr W
  Title
The herpes simplex virus VP16-induced complex: the makings of a regulatory switch.
  Journal
Trends Biochem Sci 28:294-304 (2003)
DOI:10.1016/S0968-0004(03)00088-4
Reference
PMID:27367734
  Authors
Fleming SB
  Title
Viral Inhibition of the IFN-Induced JAK/STAT Signalling Pathway: Development of Live Attenuated Vaccines by Mutation of Viral-Encoded IFN-Antagonists.
  Journal
Vaccines (Basel) 4:23 (2016)
DOI:10.3390/vaccines4030023
Reference
PMID:15163721
  Authors
Yokota S, Yokosawa N, Okabayashi T, Suzutani T, Miura S, Jimbow K, Fujii N
  Title
Induction of suppressor of cytokine signaling-3 by herpes simplex virus type 1 contributes to inhibition of the interferon signaling pathway.
  Journal
J Virol 78:6282-6 (2004)
DOI:10.1128/JVI.78.12.6282-6286.2004
Reference
PMID:23864622
  Authors
Gu H, Zheng Y, Roizman B
  Title
Interaction of herpes simplex virus ICP0 with ND10 bodies: a sequential process of adhesion, fusion, and retention.
  Journal
J Virol 87:10244-54 (2013)
DOI:10.1128/JVI.01487-13
Reference
PMID:21994592
  Authors
Tavalai N, Stamminger T
  Title
Interplay between Herpesvirus Infection and Host Defense by PML Nuclear Bodies.
  Journal
Viruses 1:1240-64 (2009)
DOI:10.3390/v1031240
Reference
PMID:21146386
  Authors
Horst D, Verweij MC, Davison AJ, Ressing ME, Wiertz EJ
  Title
Viral evasion of T cell immunity: ancient mechanisms offering new applications.
  Journal
Curr Opin Immunol 23:96-103 (2011)
DOI:10.1016/j.coi.2010.11.005
Reference
PMID:12960333
  Authors
Neumann J, Eis-Hubinger AM, Koch N
  Title
Herpes simplex virus type 1 targets the MHC class II processing pathway for immune evasion.
  Journal
J Immunol 171:3075-83 (2003)
DOI:10.4049/jimmunol.171.6.3075
Reference
PMID:25798530
  Authors
Liu X, Cohen JI
  Title
The role of PI3K/Akt in human herpesvirus infection: From the bench to the bedside.
  Journal
Virology 479-480:568-77 (2015)
DOI:10.1016/j.virol.2015.02.040
Reference
PMID:28468873
  Authors
Vink EI, Smiley JR, Mohr I
  Title
Subversion of Host Responses to Energy Insufficiency by Us3 Supports Herpes Simplex Virus 1 Replication during Stress.
  Journal
J Virol 91:e00295-17 (2017)
DOI:10.1128/JVI.00295-17
Reference
PMID:18508584
  Authors
Sandri-Goldin RM
  Title
The many roles of the regulatory protein ICP27 during herpes simplex virus infection.
  Journal
Front Biosci 13:5241-56 (2008)
DOI:10.2741/3078
Reference
PMID:15078920
  Authors
Sandri-Goldin RM
  Title
Viral regulation of mRNA export.
  Journal
J Virol 78:4389-96 (2004)
DOI:10.1128/JVI.78.9.4389-4396.2004
Reference
PMID:27154074
  Authors
Yu X, He S
  Title
The interplay between human herpes simplex virus infection and the apoptosis and necroptosis cell death pathways.
  Journal
Virol J 13:77 (2016)
DOI:10.1186/s12985-016-0528-0
Related
pathway
btax03040  Spliceosome
btax03050  Proteasome
btax04115  p53 signaling pathway
btax04151  PI3K-Akt signaling pathway
btax04210  Apoptosis
btax04610  Complement and coagulation cascades
btax04612  Antigen processing and presentation
btax04620  Toll-like receptor signaling pathway
btax04622  RIG-I-like receptor signaling pathway
btax04630  JAK-STAT signaling pathway
KO pathway
ko05168   

DBGET integrated database retrieval system