KEGG   PATHWAY: dsp04810
Entry
dsp04810                    Pathway                                
Name
Regulation of actin cytoskeleton - Dipodomys spectabilis (banner-tailed kangaroo rat)
Class
Cellular Processes; Cell motility
Pathway map
dsp04810  Regulation of actin cytoskeleton
dsp04810

Other DBs
GO: 0030036
Organism
Dipodomys spectabilis (banner-tailed kangaroo rat) [GN:dsp]
Gene
122121485  Lpar1; lysophosphatidic acid receptor 1 [KO:K04289]
122100828  Lpar2; lysophosphatidic acid receptor 2 [KO:K04291]
122097683  Lpar4; lysophosphatidic acid receptor 4 [KO:K04275]
122101959  Lpar5; lysophosphatidic acid receptor 5 [KO:K08390]
122122261  Cxcl12; stromal cell-derived factor 1 isoform X1 [KO:K10031]
122110827  Cxcr4; C-X-C chemokine receptor type 4 [KO:K04189]
122104962  F2; prothrombin [KO:K01313] [EC:3.4.21.5]
122117244  F2r; proteinase-activated receptor 1 [KO:K03914]
122102073  Ins; insulin [KO:K04526]
122127051  Egf; pro-epidermal growth factor [KO:K04357]
122118224  Fgf1; fibroblast growth factor 1 [KO:K18496]
122119078  Fgf2; fibroblast growth factor 2 [KO:K18497]
122127554  Fgf20; fibroblast growth factor 20 [KO:K04358]
122096618  Fgf17; fibroblast growth factor 17 isoform X1 [KO:K04358]
122112831  Fgf9; fibroblast growth factor 9 [KO:K04358]
122097662  Fgf16; fibroblast growth factor 16 [KO:K04358]
122106885  Fgf5; fibroblast growth factor 5 [KO:K04358]
122114692  Fgf7; fibroblast growth factor 7 [KO:K04358]
122122838  Fgf22; fibroblast growth factor 22 [KO:K04358]
122099887  Fgf3; fibroblast growth factor 3 [KO:K04358]
122115956  Fgf8; fibroblast growth factor 8 isoform X1 [KO:K04358]
122101870  Fgf18; fibroblast growth factor 18 [KO:K04358]
122117016  Fgf10; fibroblast growth factor 10 [KO:K04358]
122102809  Fgf6; LOW QUALITY PROTEIN: fibroblast growth factor 6 [KO:K04358]
122125586  Fgf21; fibroblast growth factor 21 [KO:K22429]
122102807  Fgf23; fibroblast growth factor 23 [KO:K22428]
122113621  Pdgfa; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
122123581  Pdgfb; platelet-derived growth factor subunit B [KO:K17386]
122104212  Pdgfd; platelet-derived growth factor D isoform X1 [KO:K05450]
122097855  Pdgfc; platelet-derived growth factor C [KO:K05450]
122109656  Insrr; insulin receptor-related protein [KO:K05086] [EC:2.7.10.1]
122112209  Egfr; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
122107616  Fgfr1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
122126852  Fgfr2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
122100692  Fgfr3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
122096494  Fgfr4; fibroblast growth factor receptor 4 isoform X1 [KO:K05095] [EC:2.7.10.1]
122106871  Pdgfra; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
122118168  Pdgfrb; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
122107516  Fn1; fibronectin isoform X1 [KO:K05717]
122116967  Itga1; integrin alpha-1 isoform X1 [KO:K06480]
122116951  Itga2; integrin alpha-2 [KO:K06481]
122100605  Itga2b; integrin alpha-IIb isoform X1 [KO:K06476]
122103268  Itga3; integrin alpha-3 [KO:K06482]
122114964  Itga4; integrin alpha-4 [KO:K06483]
122124347  Itga5; integrin alpha-5 [KO:K06484]
122120069  Itga6; integrin alpha-6 isoform X1 [KO:K06485]
122124386  integrin alpha-7 [KO:K06583]
122113136  Itga8; integrin alpha-8 [KO:K06584]
122096773  Itga9; integrin alpha-9 [KO:K06585]
122109053  Itga10; integrin alpha-10 isoform X1 [KO:K06586]
122122943  Itga11; integrin alpha-11 [KO:K06587]
122114967  Itgav; integrin alpha-V [KO:K06487]
122096293  Itgal; integrin alpha-L [KO:K05718]
122096284  integrin alpha-M-like [KO:K06461]
122096282  integrin alpha-X-like isoform X1 [KO:K06462]
122096283  integrin alpha-D-like isoform X1 [KO:K06594]
122124862  Itgae; integrin alpha-E [KO:K06524]
122112991  Itgb1; integrin beta-1 [KO:K05719]
122114242  integrin beta-2-like [KO:K06464]
122101293  Itgb2; integrin beta-2 [KO:K06464]
122103395  Itgb3; integrin beta-3 [KO:K06493]
122094922  Itgb4; integrin beta-4 [KO:K06525]
122097598  Itgb5; integrin beta-5 [KO:K06588]
122110843  Itgb6; integrin beta-6 [KO:K06589]
122124271  Itgb7; integrin beta-7 [KO:K06590]
122121557  Itgb8; integrin beta-8 isoform X1 [KO:K06591]
122098556  Kng1; kininogen-1 isoform X1 [KO:K03898]
122118653  Bdkrb1; B1 bradykinin receptor [KO:K03915]
122118756  Bdkrb2; B2 bradykinin receptor [KO:K03916]
122105224  Chrm1; muscarinic acetylcholine receptor M1 [KO:K04129]
122105971  Chrm2; muscarinic acetylcholine receptor M2 [KO:K04130]
122112994  Chrm3; muscarinic acetylcholine receptor M3 [KO:K04131]
122105184  Chrm4; muscarinic acetylcholine receptor M4 [KO:K04132]
122114594  Chrm5; muscarinic acetylcholine receptor M5 [KO:K04133]
122107097  C5; complement C5 [KO:K03994]
122116949  C6; complement component C6 [KO:K03995]
122117001  C7; complement component C7 [KO:K03996]
122124594  C8a; complement component C8 alpha chain [KO:K03997]
122124589  C8b; complement component C8 beta chain [KO:K03998]
122099720  C8g; complement component C8 gamma chain isoform X1 [KO:K03999]
122116988  C9; complement component C9 [KO:K04000]
122113573  Gna12; guanine nucleotide-binding protein subunit alpha-12 [KO:K04346]
122128327  Gna13; guanine nucleotide-binding protein subunit alpha-13 [KO:K04639]
122104327  Gng12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
122112045  Fgd1; FYVE, RhoGEF and PH domain-containing protein 1 [KO:K05720]
122113613  Fgd3; FYVE, RhoGEF and PH domain-containing protein 3 isoform X1 [KO:K05722]
122125312  Ptk2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
122126159  Bcar1; breast cancer anti-estrogen resistance protein 1 isoform X1 [KO:K05726]
122095902  Crkl; crk-like protein [KO:K04438]
122102190  Crk; adapter molecule crk isoform X1 [KO:K04438]
122126811  Dock1; dedicator of cytokinesis protein 1 [KO:K13708]
122120491  Src; proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
122104519  Sos1; son of sevenless homolog 1 isoform X1 [KO:K03099]
122106484  Sos2; son of sevenless homolog 2 [KO:K03099]
122095011  Hras; GTPase HRas isoform X1 [KO:K02833]
122098841  Kras; GTPase KRas isoform X1 [KO:K07827]
122118367  Nras; GTPase NRas [KO:K07828]
122125793  Rras; ras-related protein R-Ras [KO:K07829]
122117759  Rras2; ras-related protein R-Ras2 [KO:K07830]
122095273  Mras; ras-related protein M-Ras [KO:K07831]
122097094  Arhgef6; rho guanine nucleotide exchange factor 6 isoform X1 [KO:K05729]
122095294  Pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
122121501  Pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
122107232  Pik3ca; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
122123339  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform-like [KO:K00922] [EC:2.7.1.153]
122108047  phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
122100872  Pik3r2; LOW QUALITY PROTEIN: phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
122117343  Pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
122104889  Vav3; guanine nucleotide exchange factor VAV3 isoform X1 [KO:K05730]
122122780  Vav1; proto-oncogene vav [KO:K05730]
122108904  Vav2; guanine nucleotide exchange factor VAV2 isoform X1 [KO:K05730]
122114257  Tiam1; rho guanine nucleotide exchange factor TIAM1 [KO:K05731]
122098764  Araf; serine/threonine-protein kinase A-Raf [KO:K08845] [EC:2.7.11.1]
122105936  Braf; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
122107826  Raf1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
122111177  Mos; proto-oncogene serine/threonine-protein kinase mos [KO:K04367] [EC:2.7.11.1]
122114391  Map2k1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
122099331  Map2k2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
122095844  Mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
122096287  Mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
122097416  Akt2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
122101263  Akt1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
122126696  Akt3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
122112907  Rgcc; regulator of cell cycle RGCC isoform X1 [KO:K26108]
122097417  Arhgef1; rho guanine nucleotide exchange factor 1 isoform X1 [KO:K12330]
122110410  Arhgef12; rho guanine nucleotide exchange factor 12 isoform X1 [KO:K07532]
122125742  Arhgap35; rho GTPase-activating protein 35 [KO:K05732]
122095683  Rhoa; transforming protein RhoA [KO:K04513]
122115017  transforming protein RhoA-like [KO:K04513]
122113510  Rac1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
122119204  Rac2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
122099403  Rac3; ras-related C3 botulinum toxin substrate 3 [KO:K07861]
122119115  cell division control protein 42 homolog [KO:K04393]
122115178  Cdc42; cell division control protein 42 homolog [KO:K04393]
122115583  Pak1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
122097055  Pak2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
122116371  Pak3; serine/threonine-protein kinase PAK 3 isoform X1 [KO:K05733] [EC:2.7.11.1]
122097586  Pak4; serine/threonine-protein kinase PAK 4 isoform X1 [KO:K05734] [EC:2.7.11.1]
122120469  Pak5; serine/threonine-protein kinase PAK 5 [KO:K05736] [EC:2.7.11.1]
122114535  serine/threonine-protein kinase PAK 6 [KO:K05735] [EC:2.7.11.1]
122122746  Arhgef7; rho guanine nucleotide exchange factor 7 isoform X1 [KO:K13710]
122117490  Git1; ARF GTPase-activating protein GIT1 [KO:K05737]
122104238  Rock1; rho-associated protein kinase 1 [KO:K04514] [EC:2.7.11.1]
122108760  Rock2; rho-associated protein kinase 2 [KO:K17388] [EC:2.7.11.1]
122120488  Mylk2; myosin light chain kinase 2, skeletal/cardiac muscle [KO:K00907] [EC:2.7.11.18]
122096833  Mylk; myosin light chain kinase, smooth muscle isoform X1 [KO:K00907] [EC:2.7.11.18]
122096857  Mylk3; myosin light chain kinase 3 [KO:K00907] [EC:2.7.11.18]
122108431  Mylk4; myosin light chain kinase family member 4 [KO:K00907] [EC:2.7.11.18]
122104673  Ppp1ca; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
122098491  Ppp1cc; serine/threonine-protein phosphatase PP1-gamma catalytic subunit isoform X1 [KO:K06269] [EC:3.1.3.16]
122122432  Ppp1cb; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
122124417  Ppp1r12a; protein phosphatase 1 regulatory subunit 12A isoform X1 [KO:K06270]
122109161  Ppp1r12b; protein phosphatase 1 regulatory subunit 12B isoform X1 [KO:K12329]
122110725  Ppp1r12c; protein phosphatase 1 regulatory subunit 12C isoform X1 [KO:K17457]
122098548  Myl2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform isoform X1 [KO:K10351]
122128070  Myl7; myosin regulatory light chain 2, atrial isoform [KO:K12754]
122120489  Myl9; myosin regulatory light polypeptide 9 [KO:K12755]
122113837  Myl10; myosin regulatory light chain 10 [KO:K12756]
122104423  myosin regulatory light polypeptide 9 [KO:K12757]
122104424  Myl12b; myosin regulatory light chain 12B [KO:K12757]
122096264  Mylpf; myosin regulatory light chain 2, skeletal muscle isoform isoform X1 [KO:K12758]
122119137  Myh9; myosin-9 [KO:K10352]
122123759  Myh11; myosin-11 isoform X1 [KO:K10352]
122100399  Myh10; myosin-10 [KO:K10352]
122125607  Myh14; LOW QUALITY PROTEIN: myosin-14 [KO:K10352]
122118085  Diaph1; protein diaphanous homolog 1 isoform X1 [KO:K05740]
122095527  Diaph2; protein diaphanous homolog 2 [KO:K05741]
122115294  Slc9a1; sodium/hydrogen exchanger 1 [KO:K05742]
122119559  Pip5k1c; phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform X1 [KO:K00889] [EC:2.7.1.68]
122124655  Pip5k1b; phosphatidylinositol 4-phosphate 5-kinase type-1 beta isoform X1 [KO:K00889] [EC:2.7.1.68]
122109212  Pip5k1a; phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X1 [KO:K00889] [EC:2.7.1.68]
122113081  Pip4k2a; phosphatidylinositol 5-phosphate 4-kinase type-2 alpha [KO:K00920] [EC:2.7.1.149]
122124409  Pip4k2c; phosphatidylinositol 5-phosphate 4-kinase type-2 gamma [KO:K00920] [EC:2.7.1.149]
122101164  Pip4k2b; phosphatidylinositol 5-phosphate 4-kinase type-2 beta [KO:K00920] [EC:2.7.1.149]
122107349  Pikfyve; 1-phosphatidylinositol 3-phosphate 5-kinase [KO:K00921] [EC:2.7.1.150]
122114821  Limk1; LIM domain kinase 1 isoform X1 [KO:K05743] [EC:2.7.11.1]
122095919  Limk2; LIM domain kinase 2 isoform X1 [KO:K05744] [EC:2.7.11.1]
122112863  Diaph3; protein diaphanous homolog 3 [KO:K05745]
122099362  Baiap2; brain-specific angiogenesis inhibitor 1-associated protein 2 isoform X1 [KO:K05627]
122102743  Enah; protein enabled homolog isoform X1 [KO:K05746]
122121770  Wasl; neural Wiskott-Aldrich syndrome protein [KO:K23612]
122115165  Wasf2; wiskott-Aldrich syndrome protein family member 2 [KO:K05748]
122122976  Cyfip1; cytoplasmic FMR1-interacting protein 1 isoform X1 [KO:K05749]
122125028  cytoplasmic FMR1-interacting protein 2 [KO:K05749]
122114972  Nckap1; nck-associated protein 1 isoform X1 [KO:K05750]
122124083  Nckap1l; nck-associated protein 1-like [KO:K05750]
122096468  Abi2; abl interactor 2 isoform X1 [KO:K05751]
122108177  Brk1; protein BRICK1 [KO:K05752]
122125024  protein BRICK1-like [KO:K05752]
122118547  Wasf1; wiskott-Aldrich syndrome protein family member 1 isoform X1 [KO:K05753]
122117437  Actr2; actin-related protein 2 [KO:K17260]
122112319  Actr3; actin-related protein 3 [KO:K18584]
122105979  Actr3b; actin-related protein 3B isoform X1 [KO:K18584]
122113650  Arpc1b; actin-related protein 2/3 complex subunit 1B [KO:K05757]
122113781  Arpc1a; actin-related protein 2/3 complex subunit 1A [KO:K05757]
122107398  Arpc2; actin-related protein 2/3 complex subunit 2 [KO:K05758]
122115033  actin-related protein 2/3 complex subunit 2-like [KO:K05758]
122124266  actin-related protein 2/3 complex subunit 2-like [KO:K05758]
122098535  Arpc3; actin-related protein 2/3 complex subunit 3 [KO:K05756]
122107833  Arpc4; actin-related protein 2/3 complex subunit 4 [KO:K05755]
122103730  Arpc5; actin-related protein 2/3 complex subunit 5 [KO:K05754]
122107112  Arpc5l; actin-related protein 2/3 complex subunit 5-like protein isoform X1 [KO:K05754]
122113601  Actb; actin, cytoplasmic 1 [KO:K05692]
122099409  Actg1; actin, cytoplasmic 2 [KO:K05692]
122095210  Pfn2; profilin-2 isoform X1 [KO:K05759]
122096536  Pfn3; profilin-3 [KO:K05759]
122122510  Pfn4; profilin-4 [KO:K05759]
122108580  Pfn1; profilin-1 [KO:K05759]
122099008  Pxn; paxillin isoform X1 [KO:K05760]
122127539  Ezr; ezrin isoform X1 [KO:K08007]
122110202  Rdx; radixin [KO:K05762]
122096399  Msn; moesin [KO:K05763]
122108525  Tmsb4x; thymosin beta-4 [KO:K05764]
122105005  Cfl1; cofilin-1 [KO:K05765]
122106514  Cfl2; cofilin-2 isoform X1 [KO:K05765]
122105309  Ssh3; protein phosphatase Slingshot homolog 3 isoform X1 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
122117241  Ssh2; protein phosphatase Slingshot homolog 2 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
122102683  Ssh1; protein phosphatase Slingshot homolog 1 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
122116475  Vcl; vinculin isoform X1 [KO:K05700]
122099983  Iqgap1; ras GTPase-activating-like protein IQGAP1 isoform X1 [KO:K16848]
122117116  Iqgap2; ras GTPase-activating-like protein IQGAP2 [KO:K05767]
122109712  Iqgap3; ras GTPase-activating-like protein IQGAP3 [KO:K05767]
122121586  Scin; adseverin [KO:K05768]
122107044  Gsn; gelsolin isoform X1 [KO:K05768]
122118667  Actn1; alpha-actinin-1 isoform X1 [KO:K05699]
122097556  Actn4; alpha-actinin-4 isoform X1 [KO:K05699]
122122822  Apc2; LOW QUALITY PROTEIN: adenomatous polyposis coli protein 2 [KO:K02085]
122118219  Apc; adenomatous polyposis coli protein isoform X1 [KO:K02085]
122112769  Spata13; spermatogenesis-associated protein 13 isoform X1 [KO:K05769]
Compound
C00681  1-Acyl-sn-glycerol 3-phosphate
C01996  Acetylcholine
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11554  1-Phosphatidyl-1D-myo-inositol 3,4-bisphosphate
Reference
PMID:14744429
  Authors
Burridge K, Wennerberg K.
  Title
Rho and Rac take center stage.
  Journal
Cell 116:167-79 (2004)
DOI:10.1016/S0092-8674(04)00003-0
Reference
PMID:11082269
  Authors
Schmitz AA, Govek EE, Bottner B, Van Aelst L.
  Title
Rho GTPases: signaling, migration, and invasion.
  Journal
Exp Cell Res 261:1-12 (2000)
DOI:10.1006/excr.2000.5049
Reference
PMID:11152757
  Authors
Takai Y, Sasaki T, Matozaki T.
  Title
Small GTP-binding proteins.
  Journal
Physiol Rev 81:153-208 (2001)
DOI:10.1152/physrev.2001.81.1.153
Reference
PMID:12700767
  Authors
Pollard TD.
  Title
The cytoskeleton, cellular motility and the reductionist agenda.
  Journal
Nature 422:741-5 (2003)
DOI:10.1038/nature01598
Reference
PMID:14657486
  Authors
Ridley AJ, Schwartz MA, Burridge K, Firtel RA, Ginsberg MH, Borisy G, Parsons JT, Horwitz AR.
  Title
Cell migration: integrating signals from front to back.
  Journal
Science 302:1704-9 (2003)
DOI:10.1126/science.1092053
Reference
PMID:11082272
  Authors
Sastry SK, Burridge K.
  Title
Focal adhesions: a nexus for intracellular signaling and cytoskeletal dynamics.
  Journal
Exp Cell Res 261:25-36 (2000)
DOI:10.1006/excr.2000.5043
Reference
PMID:10574699
  Authors
Fukata M, Nakagawa M, Kuroda S, Kaibuchi K.
  Title
Cell adhesion and Rho small GTPases.
  Journal
J Cell Sci 112 ( Pt 24):4491-500 (1999)
Related
pathway
dsp04010  MAPK signaling pathway
dsp04510  Focal adhesion
dsp04520  Adherens junction
KO pathway
ko04810   
LinkDB

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