KEGG   PATHWAY: aamp05164
Entry
aamp05164                   Pathway                                
Name
Influenza A - Arvicola amphibius (Eurasian water vole)
Description
Influenza is a contagious respiratory disease caused by influenza virus infection. Influenza A virus is responsible for both annual seasonal epidemics and periodic worldwide pandemics. Novel strains that cause pandemics arise from avian influenza virus by genetic reassortment among influenza viruses and two surface glycoproteins HA and NA form the basis of serologically distinct virus types. The innate immune system recognizes invaded virus through multiple mechanisms. Viral non-structural NS1 protein is a multifunctional virulence factor that interfere IFN-mediated antiviral response. It inhibits IFN production by blocking activation of transcription factors such as NF-kappa B and IRF3. NS1 further inhibits the activation of IFN-induced antiviral genes. PB1-F2 protein is another virulence factor that induce apoptosis of infected cells, which results in life-threatening bronchiolitis.
Class
Human Diseases; Infectious disease: viral
Pathway map
aamp05164  Influenza A
aamp05164

Organism
Arvicola amphibius (Eurasian water vole) [GN:aamp]
Gene
119820791  Plg; plasminogen [KO:K01315] [EC:3.4.21.7]
119806814  trypsin-4 isoform X1 [KO:K01312] [EC:3.4.21.4]
119806815  anionic trypsin-2-like isoform X1 [KO:K01312] [EC:3.4.21.4]
119806817  anionic trypsin-2-like isoform X1 [KO:K01312] [EC:3.4.21.4]
119806819  cationic trypsin-3 [KO:K01312] [EC:3.4.21.4]
119806820  anionic trypsin-2-like [KO:K01312] [EC:3.4.21.4]
119806822  anionic trypsin-2-like isoform X1 [KO:K01312] [EC:3.4.21.4]
119806823  anionic trypsin-2-like [KO:K01312] [EC:3.4.21.4]
119806824  Prss2; trypsin-2 [KO:K01312] [EC:3.4.21.4]
119806826  cationic trypsin-3-like [KO:K01312] [EC:3.4.21.4]
119806827  trypsin V-A-like [KO:K01312] [EC:3.4.21.4]
119806828  trypsin V-A-like [KO:K01312] [EC:3.4.21.4]
119806832  trypsin-4-like [KO:K01312] [EC:3.4.21.4]
119824625  Tmprss2; transmembrane protease serine 2 isoform X1 [KO:K09633] [EC:3.4.21.122]
119810724  Tmprss4; transmembrane protease serine 4 isoform X1 [KO:K09635] [EC:3.4.21.-]
119806744  transmembrane protease serine 11D-like [KO:K09641] [EC:3.4.21.-]
119822917  Prkcb; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
119824522  Oas3; 2'-5'-oligoadenylate synthase 3 [KO:K14216] [EC:2.7.7.84]
119824530  Oas1; 2'-5'-oligoadenylate synthase 1 [KO:K14216] [EC:2.7.7.84]
119824811  Oas2; 2'-5'-oligoadenylate synthase 2 [KO:K14216] [EC:2.7.7.84]
119824866  2'-5'-oligoadenylate synthase 1A-like [KO:K14216] [EC:2.7.7.84]
119827862  2-5A-dependent ribonuclease-like isoform X1 [KO:K01165]
119827863  2-5A-dependent ribonuclease-like [KO:K01165]
119801936  Dnajb1; dnaJ homolog subfamily B member 1 isoform X1 [KO:K09507]
119799950  Dnajc3; dnaJ homolog subfamily C member 3 [KO:K09523]
119808127  Eif2ak2; interferon-induced, double-stranded RNA-activated protein kinase [KO:K16195] [EC:2.7.11.1]
119818610  Eif2s1; eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
119811844  Trim25; E3 ubiquitin/ISG15 ligase TRIM25 [KO:K10652] [EC:2.3.2.27]
119826628  Ddx58; antiviral innate immune response receptor RIG-I [KO:K12646] [EC:5.6.2.6]
119819080  Ifih1; interferon-induced helicase C domain-containing protein 1 [KO:K12647] [EC:5.6.2.6]
119810522  Nlrx1; NLR family member X1 [KO:K12653]
119814914  Mavs; mitochondrial antiviral-signaling protein [KO:K12648]
119816335  Chuk; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
119812324  Ikbkb; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
119804668  Ikbkg; NF-kappa-B essential modulator isoform X1 [KO:K07210]
119820618  Nfkbib; NF-kappa-B inhibitor beta [KO:K02581]
119818958  Nfkbia; NF-kappa-B inhibitor alpha [KO:K04734]
119801102  Nfkb1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
119803437  Rela; transcription factor p65 isoform X1 [KO:K04735]
119812470  Tlr3; toll-like receptor 3 isoform X1 [KO:K05401]
119804058  Ticam1; TIR domain-containing adapter molecule 1 [KO:K05842]
119818887  Traf3; TNF receptor-associated factor 3 isoform X1 [KO:K03174]
119803361  Tbk1; serine/threonine-protein kinase TBK1 [KO:K05410] [EC:2.7.11.10]
119827931  Ikbke; inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X1 [KO:K07211] [EC:2.7.11.10]
119802528  Irf3; interferon regulatory factor 3 isoform X1 [KO:K05411]
119822927  Ep300; histone acetyltransferase p300 [KO:K04498] [EC:2.3.1.48]
119811558  LOW QUALITY PROTEIN: CREB-binding protein [KO:K04498] [EC:2.3.1.48]
119818005  Tlr4; toll-like receptor 4 [KO:K10160]
119804959  Tlr7; toll-like receptor 7 [KO:K05404]
119809015  Myd88; myeloid differentiation primary response protein MyD88 [KO:K04729]
119822715  Irak4; interleukin-1 receptor-associated kinase 4 [KO:K04733] [EC:2.7.11.1]
119821228  Irf7; interferon regulatory factor 7 isoform X1 [KO:K09447]
119813991  Il1a; interleukin-1 alpha [KO:K04383]
119814887  Il1b; interleukin-1 beta [KO:K04519]
119808459  Il6; interleukin-6 [KO:K05405]
119826750  Il12a; interleukin-12 subunit alpha [KO:K05406]
119811033  Il12b; interleukin-12 subunit beta [KO:K05425]
119822506  Tnf; tumor necrosis factor [KO:K03156]
119812596  C-C motif chemokine 2-like [KO:K14624]
119812726  C-C motif chemokine 12-like [KO:K14624]
119811677  Ccl5; C-C motif chemokine 5 [KO:K12499]
119810520  Cxcl10; C-X-C motif chemokine 10 [KO:K12671]
119810539  Icam1; intercellular adhesion molecule 1 [KO:K06490]
121677052  interferon alpha-12-like [KO:K05414]
121677053  interferon alpha-12-like [KO:K05414]
121677054  interferon alpha-9-like [KO:K05414]
119817047  interferon alpha-12-like [KO:K05414]
119817048  LOW QUALITY PROTEIN: interferon alpha-12-like [KO:K05414]
119817051  interferon alpha-12-like [KO:K05414]
119817054  interferon alpha-12-like [KO:K05414]
119817055  interferon alpha-12-like [KO:K05414]
119817056  interferon alpha-12-like [KO:K05414]
119817057  interferon alpha-12-like [KO:K05414]
119817059  interferon alpha-12-like [KO:K05414]
119817275  interferon alpha-12-like [KO:K05414]
119805874  interferon alpha-12-like [KO:K05414]
119805875  interferon alpha-12-like [KO:K05414]
119805877  interferon alpha-12-like [KO:K05414]
119805879  interferon alpha-12-like [KO:K05414]
119805881  interferon alpha-12-like [KO:K05414]
119805882  interferon alpha-12-like [KO:K05414]
119805887  interferon alpha-12-like [KO:K05414]
119805888  interferon alpha-12-like [KO:K05414]
119805889  interferon alpha-12-like [KO:K05414]
119805892  interferon alpha-9-like [KO:K05414]
119816165  Ifnb1; LOW QUALITY PROTEIN: interferon beta [KO:K05415]
119817276  interferon beta-like [KO:K05415]
119825470  Ifnar1; interferon alpha/beta receptor 1 [KO:K05130]
119824686  Ifnar2; interferon alpha/beta receptor 2 [KO:K05131]
119816123  Jak1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
119809989  Tyk2; non-receptor tyrosine-protein kinase TYK2 [KO:K11219] [EC:2.7.10.2]
119812431  Socs3; suppressor of cytokine signaling 3 [KO:K04696]
119803912  Stat1; signal transducer and activator of transcription 1-alpha/beta [KO:K11220]
119803231  Stat2; signal transducer and activator of transcription 2 [KO:K11221]
119799968  Irf9; interferon regulatory factor 9 isoform X1 [KO:K04693]
119824623  Mx1; interferon-induced GTP-binding protein Mx1 [KO:K14754]
119825258  interferon-induced GTP-binding protein Mx1-like isoform X1 [KO:K14754]
119800877  Adar; double-stranded RNA-specific adenosine deaminase isoform X1 [KO:K12968] [EC:3.5.4.37]
119809756  Pml; protein PML isoform X1 [KO:K10054] [EC:2.3.2.-]
119803682  Ifng; interferon gamma [KO:K04687]
119821190  Ifngr1; interferon gamma receptor 1 [KO:K05132]
119825404  Ifngr2; interferon gamma receptor 2 [KO:K05133]
119822265  Jak2; tyrosine-protein kinase JAK2 isoform X1 [KO:K04447] [EC:2.7.10.2]
119811145  Ciita; MHC class II transactivator isoform X1 [KO:K08060] [EC:2.7.11.1]
119804328  H-2 class II histocompatibility antigen, A-R alpha chain-like [KO:K06752]
119822584  HLA class II histocompatibility antigen, DO beta chain [KO:K06752]
119823000  H-2 class II histocompatibility antigen, E-U alpha chain [KO:K06752]
119823797  H-2 class II histocompatibility antigen, E-D beta chain-like [KO:K06752]
121677314  uncharacterized protein LOC121677314 [KO:K06752]
119823089  RLA class II histocompatibility antigen, DP alpha-1 chain isoform X1 [KO:K06752]
119823094  H-2 class II histocompatibility antigen, A-K alpha chain [KO:K06752]
119823105  class II histocompatibility antigen, M beta 1 chain [KO:K06752]
119823315  rano class II histocompatibility antigen, A beta chain-like [KO:K06752]
119823357  HLA class II histocompatibility antigen, DP beta 1 chain [KO:K06752]
119823381  LOW QUALITY PROTEIN: HLA class II histocompatibility antigen, DO alpha chain [KO:K06752]
119823508  H-2 class II histocompatibility antigen, A-F alpha chain-like [KO:K06752]
119823509  H-2 class II histocompatibility antigen, A-U beta chain-like [KO:K06752]
119823798  H-2 class II histocompatibility antigen, E-S beta chain-like [KO:K06752]
119823958  H-2 class II histocompatibility antigen, I-E beta chain [KO:K06752]
119823967  class II histocompatibility antigen, M alpha chain [KO:K06752]
119812354  Nlrp3; NACHT, LRR and PYD domains-containing protein 3 isoform X1 [KO:K12800]
119826297  apoptosis-associated speck-like protein containing a CARD [KO:K12799]
119809530  caspase-1-like [KO:K01370] [EC:3.4.22.36]
119810589  interleukin-18 isoform X1 [KO:K05482]
119810590  interleukin-18-like [KO:K05482]
119813962  Il33; interleukin-33 [KO:K12967]
119808979  Pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
119817743  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
119812102  Pik3r2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
119816315  Pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
119810503  Pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
119826317  Pik3ca; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
119818643  Akt1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
119820487  Akt2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
119827246  Akt3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
119823258  Ccnd3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
119803317  Cdk4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
119807882  Cdk6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
119826387  Tnfsf10; tumor necrosis factor ligand superfamily member 10 [KO:K04721]
119799946  tumor necrosis factor receptor superfamily member 10B-like isoform X1 [KO:K04722]
119827881  Faslg; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
119804936  Fas; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
119808154  Tnfrsf1a; tumor necrosis factor receptor superfamily member 1A isoform X1 [KO:K03158]
119801899  Tradd; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
119802203  Fadd; FAS-associated death domain protein [KO:K02373]
119803862  Casp8; caspase-8 [KO:K04398] [EC:3.4.22.61]
119806482  Bid; BH3-interacting domain death agonist [KO:K04726]
119802627  Bax; apoptosis regulator BAX isoform X1 [KO:K02159]
119823918  Bak1; bcl-2 homologous antagonist/killer [KO:K14021]
119812709  Vdac1; LOW QUALITY PROTEIN: voltage-dependent anion-selective channel protein 1 [KO:K05862]
119807859  ADP/ATP translocase 2-like [KO:K05863]
119800309  ADP/ATP translocase 2-like [KO:K05863]
119815168  ADP/ATP translocase 2-like [KO:K05863]
119817121  LOW QUALITY PROTEIN: ADP/ATP translocase 1-like [KO:K05863]
119804458  ADP/ATP translocase 2-like [KO:K05863]
119804649  Slc25a5; ADP/ATP translocase 2 [KO:K05863]
119812148  Slc25a4; ADP/ATP translocase 1 [KO:K05863]
119812681  ADP/ATP translocase 2-like [KO:K05863]
119819282  ADP/ATP translocase 2-like [KO:K05863]
119826727  Slc25a31; LOW QUALITY PROTEIN: ADP/ATP translocase 4 [KO:K05863]
119807948  cytochrome c, somatic-like [KO:K08738]
119827640  cytochrome c, somatic-like [KO:K08738]
119812378  cytochrome c, somatic [KO:K08738]
119812503  cytochrome c, somatic-like [KO:K08738]
119819008  cytochrome c, testis-specific [KO:K08738]
119807481  cytochrome c, somatic [KO:K08738]
119803346  Apaf1; apoptotic protease-activating factor 1 [KO:K02084]
119817619  Casp9; caspase-9 [KO:K04399] [EC:3.4.22.62]
119812861  Casp3; caspase-3 [KO:K02187] [EC:3.4.22.56]
119825733  Cpsf4; cleavage and polyadenylation specificity factor subunit 4 isoform X1 [KO:K14404]
119804034  LOW QUALITY PROTEIN: polyadenylate-binding protein 2-like [KO:K14396]
119804035  LOW QUALITY PROTEIN: polyadenylate-binding protein 2-like [KO:K14396]
119802339  Pabpn1l; embryonic polyadenylate-binding protein 2 [KO:K14396]
119799971  LOW QUALITY PROTEIN: polyadenylate-binding protein 2-like [KO:K14396]
119804360  Nxf5; nuclear RNA export factor 5 [KO:K14284]
119804397  Nxf3; nuclear RNA export factor 3 [KO:K14284]
119809909  Nxf1; nuclear RNA export factor 1 isoform X1 [KO:K14284]
119805371  LOW QUALITY PROTEIN: nuclear RNA export factor 2-like [KO:K14284]
119815886  Nxt1; NTF2-related export protein 1 [KO:K14285]
119804382  Nxt2; NTF2-related export protein 2 [KO:K14285]
119806795  LOW QUALITY PROTEIN: heterogeneous nuclear ribonucleoprotein U-like protein 1 [KO:K15047]
119820515  Hnrnpul1; heterogeneous nuclear ribonucleoprotein U-like protein 1 isoform X1 [KO:K15047]
119815443  Rae1; mRNA export factor [KO:K14298]
119811265  Nup98; nuclear pore complex protein Nup98-Nup96 isoform X1 [KO:K14297]
119807552  Rsad2; radical S-adenosyl methionine domain-containing protein 2 [KO:K15045]
119800721  Fdps; farnesyl pyrophosphate synthase isoform X1 [KO:K00787] [EC:2.5.1.1 2.5.1.10]
119827564  farnesyl pyrophosphate synthase-like [KO:K00787] [EC:2.5.1.1 2.5.1.10]
119812144  Prkca; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
119808272  Raf1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
119805902  LOW QUALITY PROTEIN: RAF proto-oncogene serine/threonine-protein kinase-like [KO:K04366] [EC:2.7.11.1]
119809903  Map2k1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
119827491  Map2k2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
119824680  Mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
119813356  Mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
119811081  Actg1; actin, cytoplasmic 2 [KO:K05692]
119825660  Actb; actin, cytoplasmic 1 [KO:K05692]
119809549  Rab11a; ras-related protein Rab-11A [KO:K07904]
119817013  Rab11b; ras-related protein Rab-11B [KO:K07905]
119814368  Xpo1; exportin-1 isoform X1 [KO:K14290]
119825074  Kpna1; importin subunit alpha-5 [KO:K23940]
119824374  Kpna7; importin subunit alpha-8 [KO:K15043]
119812789  Kpna2; importin subunit alpha-1 [KO:K15043]
119821132  Kpna5; importin subunit alpha-6 isoform X1 [KO:K15042]
119817313  Kpna6; importin subunit alpha-7 [KO:K15042]
Compound
C00027  Hydrogen peroxide
C00080  H+
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:24225499
  Authors
Edinger TO, Pohl MO, Stertz S
  Title
Entry of influenza A virus: host factors and antiviral targets.
  Journal
J Gen Virol 95:263-77 (2014)
DOI:10.1099/vir.0.059477-0
Reference
PMID:19565019
  Authors
Kido H, Okumura Y, Takahashi E, Pan HY, Wang S, Chida J, Le TQ, Yano M
  Title
Host envelope glycoprotein processing proteases are indispensable for entry into human cells by seasonal and highly pathogenic avian influenza viruses.
  Journal
J Mol Genet Med 3:167-75 (2008)
Reference
PMID:27751627
  Authors
Ramakrishnan B, Viswanathan K, Tharakaraman K, Dancik V, Raman R, Babcock GJ, Shriver Z, Sasisekharan R
  Title
A Structural and Mathematical Modeling Analysis of the Likelihood of Antibody-Dependent Enhancement in Influenza.
  Journal
Trends Microbiol 24:933-943 (2016)
DOI:10.1016/j.tim.2016.09.003
Reference
PMID:18588994
  Authors
Thanh TT, van Doorn HR, de Jong MD
  Title
Human H5N1 influenza: current insight into pathogenesis.
  Journal
Int J Biochem Cell Biol 40:2671-4 (2008)
DOI:10.1016/j.biocel.2008.05.019
Reference
PMID:23977434
  Authors
Michael P, Brabant D, Bleiblo F, Ramana CV, Rutherford M, Khurana S, Tai TC, Kumar A, Kumar A
  Title
Influenza A induced cellular signal transduction pathways.
  Journal
J Thorac Dis 5 Suppl 2:S132-41 (2013)
DOI:10.3978/j.issn.2072-1439.2013.07.42
Reference
PMID:20020828
  Authors
Hale BG, Albrecht RA, Garcia-Sastre A
  Title
Innate immune evasion strategies of influenza viruses.
  Journal
Future Microbiol 5:23-41 (2010)
DOI:10.2217/fmb.09.108
Reference
PMID:21698289
  Authors
Sharma K, Tripathi S, Ranjan P, Kumar P, Garten R, Deyde V, Katz JM, Cox NJ, Lal RB, Sambhara S, Lal SK
  Title
Influenza A virus nucleoprotein exploits Hsp40 to inhibit PKR activation.
  Journal
PLoS One 6:e20215 (2011)
DOI:10.1371/journal.pone.0020215
Reference
PMID:19782761
  Authors
Ehrhardt C, Seyer R, Hrincius ER, Eierhoff T, Wolff T, Ludwig S
  Title
Interplay between influenza A virus and the innate immune signaling.
  Journal
Microbes Infect 12:81-7 (2010)
DOI:10.1016/j.micinf.2009.09.007
Reference
PMID:23170167
  Authors
van de Sandt CE, Kreijtz JH, Rimmelzwaan GF
  Title
Evasion of influenza A viruses from innate and adaptive immune responses.
  Journal
Viruses 4:1438-76 (2012)
DOI:10.3390/v4091438
Reference
PMID:30487536
  Authors
Long JS, Mistry B, Haslam SM, Barclay WS
  Title
Host and viral determinants of influenza A virus species specificity.
  Journal
Nat Rev Microbiol 17:67-81 (2019)
DOI:10.1038/s41579-018-0115-z
Reference
PMID:29556226
  Authors
Chen X, Liu S, Goraya MU, Maarouf M, Huang S, Chen JL
  Title
Host Immune Response to Influenza A Virus Infection.
  Journal
Front Immunol 9:320 (2018)
DOI:10.3389/fimmu.2018.00320
Reference
PMID:20130137
  Authors
Lu X, Masic A, Li Y, Shin Y, Liu Q, Zhou Y
  Title
The PI3K/Akt pathway inhibits influenza A virus-induced Bax-mediated apoptosis by negatively regulating the JNK pathway via ASK1.
  Journal
J Gen Virol 91:1439-49 (2010)
DOI:10.1099/vir.0.018465-0
Reference
PMID:18980544
  Authors
Ichinohe T, Iwasaki A, Hasegawa H
  Title
Innate sensors of influenza virus: clues to developing better intranasal vaccines.
  Journal
Expert Rev Vaccines 7:1435-45 (2008)
DOI:10.1586/14760584.7.9.1435
Reference
PMID:27231932
  Authors
Le Sage V, Cinti A, Amorim R, Mouland AJ
  Title
Adapting the Stress Response: Viral Subversion of the mTOR Signaling Pathway.
  Journal
Viruses 8:E152 (2016)
DOI:10.3390/v8060152
Reference
PMID:30510918
  Authors
Fan Y, Sanyal S, Bruzzone R
  Title
Breaking Bad: How Viruses Subvert the Cell Cycle.
  Journal
Front Cell Infect Microbiol 8:396 (2018)
DOI:10.3389/fcimb.2018.00396
Reference
PMID:21971186
  Authors
Varga ZT, Palese P
  Title
The influenza A virus protein PB1-F2: killing two birds with one stone?
  Journal
Virulence 2:542-6 (2011)
DOI:10.4161/viru.2.6.17812
Reference
PMID:30254192
  Authors
Atkin-Smith GK, Duan M, Chen W, Poon IKH
  Title
The induction and consequences of Influenza A virus-induced cell death.
  Journal
Cell Death Dis 9:1002 (2018)
DOI:10.1038/s41419-018-1035-6
Reference
PMID:30545063
  Authors
Nogales A, Martinez-Sobrido L, Topham DJ, DeDiego ML
  Title
Modulation of Innate Immune Responses by the Influenza A NS1 and PA-X Proteins.
  Journal
Viruses 10:E708 (2018)
DOI:10.3390/v10120708
Reference
PMID:21253874
  Authors
Dai X, Zhang L, Hong T
  Title
Host cellular signaling induced by influenza virus.
  Journal
Sci China Life Sci 54:68-74 (2011)
DOI:10.1007/s11427-010-4116-z
Reference
PMID:26008706
  Authors
Li J, Yu M, Zheng W, Liu W
  Title
Nucleocytoplasmic shuttling of influenza A virus proteins.
  Journal
Viruses 7:2668-82 (2015)
DOI:10.3390/v7052668
Reference
PMID:30079062
  Authors
Dou D, Revol R, Ostbye H, Wang H, Daniels R
  Title
Influenza A Virus Cell Entry, Replication, Virion Assembly and Movement.
  Journal
Front Immunol 9:1581 (2018)
DOI:10.3389/fimmu.2018.01581
Reference
PMID:23236273
  Authors
Paterson D, Fodor E
  Title
Emerging roles for the influenza A virus nuclear export protein (NEP).
  Journal
PLoS Pathog 8:e1003019 (2012)
DOI:10.1371/journal.ppat.1003019
Related
pathway
aamp00900  Terpenoid backbone biosynthesis
aamp03013  Nucleocytoplasmic transport
aamp03015  mRNA surveillance pathway
aamp04010  MAPK signaling pathway
aamp04110  Cell cycle
aamp04144  Endocytosis
aamp04210  Apoptosis
aamp04620  Toll-like receptor signaling pathway
aamp04621  NOD-like receptor signaling pathway
aamp04622  RIG-I-like receptor signaling pathway
aamp04630  JAK-STAT signaling pathway
aamp05416  Viral myocarditis
KO pathway
ko05164   
LinkDB

DBGET integrated database retrieval system