KEGG   PATHWAY: aju05164
Entry
aju05164                    Pathway                                
Name
Influenza A - Acinonyx jubatus (cheetah)
Description
Influenza is a contagious respiratory disease caused by influenza virus infection. Influenza A virus is responsible for both annual seasonal epidemics and periodic worldwide pandemics. Novel strains that cause pandemics arise from avian influenza virus by genetic reassortment among influenza viruses and two surface glycoproteins HA and NA form the basis of serologically distinct virus types. The innate immune system recognizes invaded virus through multiple mechanisms. Viral non-structural NS1 protein is a multifunctional virulence factor that interfere IFN-mediated antiviral response. It inhibits IFN production by blocking activation of transcription factors such as NF-kappa B and IRF3. NS1 further inhibits the activation of IFN-induced antiviral genes. PB1-F2 protein is another virulence factor that induce apoptosis of infected cells, which results in life-threatening bronchiolitis.
Class
Human Diseases; Infectious disease: viral
Pathway map
aju05164  Influenza A
aju05164

Organism
Acinonyx jubatus (cheetah) [GN:aju]
Gene
106985023  plasminogen [KO:K01315] [EC:3.4.21.7]
106986545  trypsin-2 isoform X2 [KO:K01312] [EC:3.4.21.4]
106970422  serine protease 1 [KO:K01312] [EC:3.4.21.4]
106965628  transmembrane protease serine 2 [KO:K09633] [EC:3.4.21.122]
106966480  transmembrane protease serine 4 [KO:K09635] [EC:3.4.21.-]
106976999  transmembrane protease serine 11D [KO:K09641] [EC:3.4.21.-]
106970449  protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
106982083  2'-5'-oligoadenylate synthase 3-like [KO:K14216] [EC:2.7.7.84]
113595144  2'-5'-oligoadenylate synthase 1-like [KO:K14216] [EC:2.7.7.84]
106966736  2-5A-dependent ribonuclease [KO:K01165]
106985852  dnaJ homolog subfamily B member 1 isoform X1 [KO:K09507]
106984226  dnaJ homolog subfamily C member 3 [KO:K09523]
106978970  interferon-induced, double-stranded RNA-activated protein kinase isoform X1 [KO:K16195] [EC:2.7.11.1]
106971552  eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
106989931  E3 ubiquitin/ISG15 ligase TRIM25 isoform X1 [KO:K10652] [EC:2.3.2.27]
106976066  RIGI; antiviral innate immune response receptor RIG-I isoform X1 [KO:K12646] [EC:5.6.2.6]
106984839  interferon-induced helicase C domain-containing protein 1 isoform X1 [KO:K12647] [EC:5.6.2.6]
106983897  NLR family member X1 [KO:K12653]
106980168  mitochondrial antiviral-signaling protein isoform X1 [KO:K12648]
106966935  inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
106990012  inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
106988817  NF-kappa-B essential modulator isoform X1 [KO:K07210]
106988322  NF-kappa-B inhibitor beta isoform X1 [KO:K02581]
106965509  NF-kappa-B inhibitor alpha [KO:K04734]
106984704  nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
106971136  transcription factor p65 [KO:K04735]
106980533  calcium-binding and coiled-coil domain-containing protein 2 isoform X1 [KO:K21348]
106982233  toll-like receptor 3 [KO:K05401]
113596324  TIR domain-containing adapter molecule 1 [KO:K05842]
106975974  TNF receptor-associated factor 3 isoform X1 [KO:K03174]
106981360  serine/threonine-protein kinase TBK1 isoform X1 [KO:K05410] [EC:2.7.11.10]
106972924  inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X1 [KO:K07211] [EC:2.7.11.10]
106983140  interferon regulatory factor 3 isoform X3 [KO:K05411]
106979918  histone acetyltransferase p300 [KO:K04498] [EC:2.3.1.48]
106978741  CREB-binding protein isoform X1 [KO:K04498] [EC:2.3.1.48]
106977278  toll-like receptor 4 isoform X1 [KO:K10160]
106971060  toll-like receptor 7 isoform X1 [KO:K05404]
106966692  myeloid differentiation primary response protein MyD88 [KO:K04729]
106978292  interleukin-1 receptor-associated kinase 4 isoform X1 [KO:K04733] [EC:2.7.11.1]
106988905  interferon regulatory factor 7 [KO:K09447]
106976018  interleukin-1 alpha isoform X1 [KO:K04383]
106976013  interleukin-1 beta [KO:K04519]
106982277  interleukin-6 [KO:K05405]
106969467  interleukin-12 subunit alpha [KO:K05406]
106967679  interleukin-12 subunit beta isoform X2 [KO:K05425]
106983958  tumor necrosis factor [KO:K03156]
106982166  interleukin-8 [KO:K10030]
106987562  C-C motif chemokine 2 [KO:K14624]
106980412  C-C motif chemokine 5 [KO:K12499]
106982115  C-X-C motif chemokine 10 [KO:K12671]
106980319  intercellular adhesion molecule 1 isoform X1 [KO:K06490]
128312015  interferon alpha-like [KO:K05414]
128312017  interferon beta-like [KO:K05414]
128312193  interferon alpha-like [KO:K05414]
106971015  interferon alpha-like [KO:K05414]
106971043  interferon alpha-2-like [KO:K05414]
106971134  interferon alpha [KO:K05414]
106989747  interferon alpha [KO:K05414]
106971145  interferon beta [KO:K05415]
106966457  interferon alpha/beta receptor 1 isoform X1 [KO:K05130]
106966459  interferon alpha/beta receptor 2 isoform X1 [KO:K05131]
106983739  tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
106980310  non-receptor tyrosine-protein kinase TYK2 [KO:K11219] [EC:2.7.10.2]
113597026  suppressor of cytokine signaling 3 [KO:K04696]
106979712  signal transducer and activator of transcription 1-alpha/beta [KO:K11220]
106986878  signal transducer and activator of transcription 2 isoform X1 [KO:K11221]
106987855  interferon regulatory factor 9 isoform X2 [KO:K04693]
106965627  interferon-induced GTP-binding protein Mx1 [KO:K14754]
106988378  double-stranded RNA-specific adenosine deaminase isoform X2 [KO:K12968] [EC:3.5.4.37]
106979429  protein PML isoform X1 [KO:K10054] [EC:2.3.2.-]
106966359  interferon gamma [KO:K04687]
106985768  interferon gamma receptor 1 [KO:K05132]
106966456  interferon gamma receptor 2 [KO:K05133]
106968145  tyrosine-protein kinase JAK2 isoform X1 [KO:K04447] [EC:2.7.10.2]
106989314  MHC class II transactivator isoform X1 [KO:K08060] [EC:2.7.11.1]
106976119  HLA class II histocompatibility antigen, DO alpha chain [KO:K06752]
106976121  HLA class II histocompatibility antigen, DM alpha chain [KO:K06752]
106976122  HLA class II histocompatibility antigen, DM beta chain isoform X1 [KO:K06752]
106976130  HLA class II histocompatibility antigen, DO beta chain-like isoform X3 [KO:K06752]
106976131  DLA class II histocompatibility antigen, DR-1 beta chain [KO:K06752]
106988373  DLA class II histocompatibility antigen, DR-1 beta chain [KO:K06752]
106988545  DLA class II histocompatibility antigen, DR-1 beta chain [KO:K06752]
106989224  HLA class II histocompatibility antigen, DR alpha chain [KO:K06752]
106976089  HLA class II histocompatibility antigen, DP beta 1 chain [KO:K06752]
106976069  HLA class II histocompatibility antigen, DP alpha 1 chain [KO:K06752]
113598914  HLA class II histocompatibility antigen, DR alpha chain-like [KO:K06752]
113598915  HLA class II histocompatibility antigen, DR alpha chain-like [KO:K06752]
106966765  NACHT, LRR and PYD domains-containing protein 3 [KO:K12800]
106979088  apoptosis-associated speck-like protein containing a CARD [KO:K12799]
106986372  interleukin-18 [KO:K05482]
106985313  interleukin-33 isoform X3 [KO:K12967]
106976917  phosphatidylinositol 3-kinase regulatory subunit alpha isoform X2 [KO:K02649]
106973297  LOW QUALITY PROTEIN: phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
106969150  phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
106984896  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
106984265  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
106973880  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
106979622  RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
106975558  RAC-gamma serine/threonine-protein kinase isoform X2 [KO:K04456] [EC:2.7.11.1]
106985046  RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
106974052  G1/S-specific cyclin-D3 isoform X2 [KO:K10152]
106975871  cyclin-dependent kinase 4 isoform X1 [KO:K02089] [EC:2.7.11.22]
106969949  cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
106990055  tumor necrosis factor ligand superfamily member 10 [KO:K04721]
106982854  tumor necrosis factor receptor superfamily member 10B-like isoform X1 [KO:K04722]
106979842  tumor necrosis factor ligand superfamily member 6 [KO:K04389]
106980953  tumor necrosis factor receptor superfamily member 6 isoform X1 [KO:K04390]
106965450  tumor necrosis factor receptor superfamily member 1A [KO:K03158]
106971422  tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
106982870  FAS-associated death domain protein [KO:K02373]
106987995  caspase-8 [KO:K04398] [EC:3.4.22.61]
106968455  BH3-interacting domain death agonist [KO:K04726]
106988699  apoptosis regulator BAX isoform X1 [KO:K02159]
106976101  bcl-2 homologous antagonist/killer [KO:K14021]
106984918  voltage-dependent anion-selective channel protein 1 [KO:K05862]
106970551  LOW QUALITY PROTEIN: ADP/ATP translocase 2-like [KO:K05863]
106970899  ADP/ATP translocase 2 [KO:K05863]
106982226  ADP/ATP translocase 1 [KO:K05863]
106982044  ADP/ATP translocase 3 [KO:K05863]
106988175  ADP/ATP translocase 4 [KO:K05863]
106973875  cytochrome c-like [KO:K08738]
128316364  cytochrome c-like [KO:K08738]
106982840  cytochrome c [KO:K08738]
106986613  cytochrome c-like [KO:K08738]
106973746  apoptotic protease-activating factor 1 isoform X1 [KO:K02084]
106975594  caspase-9 isoform X1 [KO:K04399] [EC:3.4.22.62]
106979326  caspase-3 isoform X3 [KO:K02187] [EC:3.4.22.56]
106981209  cleavage and polyadenylation specificity factor subunit 4 isoform X1 [KO:K14404]
106978611  putative cleavage and polyadenylation specificity factor subunit 4-like protein isoform X1 [KO:K14404]
106973499  LOW QUALITY PROTEIN: embryonic polyadenylate-binding protein 2 [KO:K14396]
128311416  nuclear RNA export factor 3 isoform X1 [KO:K14284]
106988798  nuclear RNA export factor 2-like isoform X4 [KO:K14284]
106974091  nuclear RNA export factor 2-like [KO:K14284]
106976278  nuclear RNA export factor 3 isoform X1 [KO:K14284]
106981719  nuclear RNA export factor 1 [KO:K14284]
106988195  NTF2-related export protein 1 [KO:K14285]
106973155  NTF2-related export protein 2 isoform X1 [KO:K14285]
106987680  heterogeneous nuclear ribonucleoprotein U-like protein 1 isoform X1 [KO:K15047]
106988889  mRNA export factor RAE1 [KO:K14298]
106966014  nuclear pore complex protein Nup98-Nup96 isoform X1 [KO:K14297]
106982970  radical S-adenosyl methionine domain-containing protein 2 isoform X1 [KO:K15045]
106981517  farnesyl pyrophosphate synthase isoform X3 [KO:K00787] [EC:2.5.1.1 2.5.1.10]
106975306  protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
106977129  RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
106980282  dual specificity mitogen-activated protein kinase kinase 1 isoform X2 [KO:K04368] [EC:2.7.12.2]
106975474  dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
106969232  mitogen-activated protein kinase 3 isoform X2 [KO:K04371] [EC:2.7.11.24]
106990008  mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
106987399  actin, cytoplasmic 2 [KO:K05692]
106984514  actin, cytoplasmic 1 [KO:K05692]
106980240  ras-related protein Rab-11A [KO:K07904]
106970775  ras-related protein Rab-11B [KO:K07905]
106973470  exportin-1 isoform X1 [KO:K14290]
106984078  importin subunit alpha-5 isoform X1 [KO:K23940]
106975327  importin subunit alpha-1 [KO:K15043]
106981217  importin subunit alpha-8 isoform X3 [KO:K15043]
106968333  importin subunit alpha-6 isoform X1 [KO:K15042]
106982419  importin subunit alpha-7 isoform X1 [KO:K15042]
Compound
C00027  Hydrogen peroxide
C00080  H+
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:24225499
  Authors
Edinger TO, Pohl MO, Stertz S
  Title
Entry of influenza A virus: host factors and antiviral targets.
  Journal
J Gen Virol 95:263-77 (2014)
DOI:10.1099/vir.0.059477-0
Reference
PMID:19565019
  Authors
Kido H, Okumura Y, Takahashi E, Pan HY, Wang S, Chida J, Le TQ, Yano M
  Title
Host envelope glycoprotein processing proteases are indispensable for entry into human cells by seasonal and highly pathogenic avian influenza viruses.
  Journal
J Mol Genet Med 3:167-75 (2008)
Reference
PMID:27751627
  Authors
Ramakrishnan B, Viswanathan K, Tharakaraman K, Dancik V, Raman R, Babcock GJ, Shriver Z, Sasisekharan R
  Title
A Structural and Mathematical Modeling Analysis of the Likelihood of Antibody-Dependent Enhancement in Influenza.
  Journal
Trends Microbiol 24:933-943 (2016)
DOI:10.1016/j.tim.2016.09.003
Reference
PMID:18588994
  Authors
Thanh TT, van Doorn HR, de Jong MD
  Title
Human H5N1 influenza: current insight into pathogenesis.
  Journal
Int J Biochem Cell Biol 40:2671-4 (2008)
DOI:10.1016/j.biocel.2008.05.019
Reference
PMID:23977434
  Authors
Michael P, Brabant D, Bleiblo F, Ramana CV, Rutherford M, Khurana S, Tai TC, Kumar A, Kumar A
  Title
Influenza A induced cellular signal transduction pathways.
  Journal
J Thorac Dis 5 Suppl 2:S132-41 (2013)
DOI:10.3978/j.issn.2072-1439.2013.07.42
Reference
PMID:20020828
  Authors
Hale BG, Albrecht RA, Garcia-Sastre A
  Title
Innate immune evasion strategies of influenza viruses.
  Journal
Future Microbiol 5:23-41 (2010)
DOI:10.2217/fmb.09.108
Reference
PMID:21698289
  Authors
Sharma K, Tripathi S, Ranjan P, Kumar P, Garten R, Deyde V, Katz JM, Cox NJ, Lal RB, Sambhara S, Lal SK
  Title
Influenza A virus nucleoprotein exploits Hsp40 to inhibit PKR activation.
  Journal
PLoS One 6:e20215 (2011)
DOI:10.1371/journal.pone.0020215
Reference
PMID:19782761
  Authors
Ehrhardt C, Seyer R, Hrincius ER, Eierhoff T, Wolff T, Ludwig S
  Title
Interplay between influenza A virus and the innate immune signaling.
  Journal
Microbes Infect 12:81-7 (2010)
DOI:10.1016/j.micinf.2009.09.007
Reference
PMID:23170167
  Authors
van de Sandt CE, Kreijtz JH, Rimmelzwaan GF
  Title
Evasion of influenza A viruses from innate and adaptive immune responses.
  Journal
Viruses 4:1438-76 (2012)
DOI:10.3390/v4091438
Reference
PMID:30487536
  Authors
Long JS, Mistry B, Haslam SM, Barclay WS
  Title
Host and viral determinants of influenza A virus species specificity.
  Journal
Nat Rev Microbiol 17:67-81 (2019)
DOI:10.1038/s41579-018-0115-z
Reference
PMID:29556226
  Authors
Chen X, Liu S, Goraya MU, Maarouf M, Huang S, Chen JL
  Title
Host Immune Response to Influenza A Virus Infection.
  Journal
Front Immunol 9:320 (2018)
DOI:10.3389/fimmu.2018.00320
Reference
PMID:20130137
  Authors
Lu X, Masic A, Li Y, Shin Y, Liu Q, Zhou Y
  Title
The PI3K/Akt pathway inhibits influenza A virus-induced Bax-mediated apoptosis by negatively regulating the JNK pathway via ASK1.
  Journal
J Gen Virol 91:1439-49 (2010)
DOI:10.1099/vir.0.018465-0
Reference
PMID:18980544
  Authors
Ichinohe T, Iwasaki A, Hasegawa H
  Title
Innate sensors of influenza virus: clues to developing better intranasal vaccines.
  Journal
Expert Rev Vaccines 7:1435-45 (2008)
DOI:10.1586/14760584.7.9.1435
Reference
PMID:27231932
  Authors
Le Sage V, Cinti A, Amorim R, Mouland AJ
  Title
Adapting the Stress Response: Viral Subversion of the mTOR Signaling Pathway.
  Journal
Viruses 8:E152 (2016)
DOI:10.3390/v8060152
Reference
PMID:30510918
  Authors
Fan Y, Sanyal S, Bruzzone R
  Title
Breaking Bad: How Viruses Subvert the Cell Cycle.
  Journal
Front Cell Infect Microbiol 8:396 (2018)
DOI:10.3389/fcimb.2018.00396
Reference
PMID:21971186
  Authors
Varga ZT, Palese P
  Title
The influenza A virus protein PB1-F2: killing two birds with one stone?
  Journal
Virulence 2:542-6 (2011)
DOI:10.4161/viru.2.6.17812
Reference
PMID:30254192
  Authors
Atkin-Smith GK, Duan M, Chen W, Poon IKH
  Title
The induction and consequences of Influenza A virus-induced cell death.
  Journal
Cell Death Dis 9:1002 (2018)
DOI:10.1038/s41419-018-1035-6
Reference
PMID:30545063
  Authors
Nogales A, Martinez-Sobrido L, Topham DJ, DeDiego ML
  Title
Modulation of Innate Immune Responses by the Influenza A NS1 and PA-X Proteins.
  Journal
Viruses 10:E708 (2018)
DOI:10.3390/v10120708
Reference
PMID:21253874
  Authors
Dai X, Zhang L, Hong T
  Title
Host cellular signaling induced by influenza virus.
  Journal
Sci China Life Sci 54:68-74 (2011)
DOI:10.1007/s11427-010-4116-z
Reference
PMID:26008706
  Authors
Li J, Yu M, Zheng W, Liu W
  Title
Nucleocytoplasmic shuttling of influenza A virus proteins.
  Journal
Viruses 7:2668-82 (2015)
DOI:10.3390/v7052668
Reference
PMID:30079062
  Authors
Dou D, Revol R, Ostbye H, Wang H, Daniels R
  Title
Influenza A Virus Cell Entry, Replication, Virion Assembly and Movement.
  Journal
Front Immunol 9:1581 (2018)
DOI:10.3389/fimmu.2018.01581
Reference
PMID:23236273
  Authors
Paterson D, Fodor E
  Title
Emerging roles for the influenza A virus nuclear export protein (NEP).
  Journal
PLoS Pathog 8:e1003019 (2012)
DOI:10.1371/journal.ppat.1003019
Related
pathway
aju00900  Terpenoid backbone biosynthesis
aju03013  Nucleocytoplasmic transport
aju03015  mRNA surveillance pathway
aju04010  MAPK signaling pathway
aju04110  Cell cycle
aju04144  Endocytosis
aju04210  Apoptosis
aju04620  Toll-like receptor signaling pathway
aju04621  NOD-like receptor signaling pathway
aju04622  RIG-I-like receptor signaling pathway
aju04630  JAK-STAT signaling pathway
aju05416  Viral myocarditis
KO pathway
ko05164   
LinkDB

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