KEGG   PATHWAY: bbis05014
Entry
bbis05014                   Pathway                                
Name
Amyotrophic lateral sclerosis - Bison bison bison (American bison)
Description
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder characterized by a progressive degeneration of motor neurons in the brain and spinal cord. In 90% of patients, ALS is sporadic, with no clear genetic linkage. On the other hand, the remaining 10% of cases show familial inheritance, with mutations in SOD1, TDP43(TARDBP), FUS, or C9orf72 genes being the most frequent causes. In spite of such difference, familial ALS and sporadic ALS have similarities in their pathological features. Proposed disease mechanisms contributing to motor neuron degeneration in ALS are: impaired proteostasis, aberrant RNA processing, mitochondrial disfunction and oxidative stress, microglia activation, and axonal dysfunction.
Class
Human Diseases; Neurodegenerative disease
Pathway map
bbis05014  Amyotrophic lateral sclerosis
bbis05014

Organism
Bison bison bison (American bison) [GN:bbis]
Gene
104990761  TP53; cellular tumor antigen p53 isoform X1 [KO:K04451]
104982832  caspase-1-like [KO:K01370] [EC:3.4.22.36]
104992258  BID; BH3-interacting domain death agonist isoform X1 [KO:K04726]
104999231  BCL2; apoptosis regulator Bcl-2 isoform X1 [KO:K02161]
104980990  bcl-2-like protein 1 [KO:K04570]
104989915  BCL2L1; bcl-2-like protein 1 [KO:K04570]
104995631  BAX; apoptosis regulator BAX [KO:K02159]
104987190  BAD; LOW QUALITY PROTEIN: bcl2-associated agonist of cell death [KO:K02158]
104982240  APAF1; apoptotic protease-activating factor 1 isoform X1 [KO:K02084]
104999778  cytochrome c [KO:K08738]
104988504  cytochrome c-like [KO:K08738]
105002922  cytochrome c 2 [KO:K08738]
104995965  CASP9; caspase-9 isoform X1 [KO:K04399] [EC:3.4.22.62]
104985538  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
105004636  SOD1; superoxide dismutase [Cu-Zn] [KO:K04565] [EC:1.15.1.1]
104986953  NDUFV1; NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial [KO:K03942] [EC:7.1.1.2]
104992940  NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial [KO:K03943] [EC:7.1.1.2]
105002486  NDUFV2; NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial [KO:K03943] [EC:7.1.1.2]
104984944  NDUFV3; NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial isoform X1 [KO:K03944]
105005064  LOW QUALITY PROTEIN: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1-like [KO:K03945]
104994319  NDUFA1; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 [KO:K03945]
104996211  NDUFA2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 [KO:K03946]
104985114  NDUFA3; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 [KO:K03947]
104992516  NDUFA4; cytochrome c oxidase subunit NDUFA4 [KO:K03948]
104998949  cytochrome c oxidase subunit NDUFA4-like [KO:K03948]
104988113  NDUFA4L2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 [KO:K03948]
104982372  NDUFA5; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 isoform X1 [KO:K03949]
104991249  NDUFA6; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 [KO:K03950]
104979755  NDUFA7; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 [KO:K03951]
104997333  NDUFA8; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 [KO:K03952]
104992211  NDUFA9; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial [KO:K03953]
104991413  NDUFA10; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial [KO:K03954]
104986581  NDUFAB1; acyl carrier protein, mitochondrial [KO:K03955]
104979718  NDUFA11; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 [KO:K03956]
105001631  NDUFA12; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 [KO:K11352]
104993848  NDUFA13; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 [KO:K11353]
104985816  NDUFB1; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 [KO:K03957]
104999382  NDUFB2; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial [KO:K03958]
105003651  NDUFB3; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 [KO:K03959]
104992487  NDUFB4; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 [KO:K03960]
104999985  NDUFB5; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial [KO:K03961]
104988316  NDUFB6; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 [KO:K03962]
104999881  NDUFB7; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 [KO:K03963]
105002710  NDUFB8; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial isoform X1 [KO:K03964]
104987825  NDUFB9; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 isoform X1 [KO:K03965]
104993066  NDUFB10; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 [KO:K03966]
105003689  NDUFS1; NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial [KO:K03934] [EC:7.1.1.2]
104984069  NDUFS2; NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial [KO:K03935] [EC:7.1.1.2]
104990360  NDUFS3; NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial [KO:K03936] [EC:7.1.1.2]
105001053  NDUFS4; NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial [KO:K03937]
105004940  NDUFS5; NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 [KO:K03938]
105000994  NDUFS6; NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial [KO:K03939]
104991945  NDUFS7; NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial [KO:K03940] [EC:7.1.1.2]
104986948  NDUFS8; NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial [KO:K03941] [EC:7.1.1.2]
104981278  NDUFC1; NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial [KO:K03967]
104998165  NDUFC2; NADH dehydrogenase [ubiquinone] 1 subunit C2 [KO:K03968]
104982907  SDHA; succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial [KO:K00234] [EC:1.3.5.1]
105002322  uncharacterized protein LOC105002322 [KO:K00235] [EC:1.3.5.1]
104984077  SDHC; succinate dehydrogenase cytochrome b560 subunit, mitochondrial [KO:K00236]
104981313  SDHD; succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial isoform X1 [KO:K00237]
104996455  cytochrome b-c1 complex subunit Rieske, mitochondrial [KO:K00411] [EC:7.1.1.8]
104991620  cytochrome c1, heme protein, mitochondrial [KO:K00413]
104997238  cytochrome b-c1 complex subunit 1, mitochondrial [KO:K00414]
104986557  cytochrome b-c1 complex subunit 2, mitochondrial [KO:K00415]
104994337  uncharacterized protein LOC104994337 isoform X1 [KO:K00416]
104983936  cytochrome b-c1 complex subunit 7 isoform X1 [KO:K00417]
104991872  cytochrome b-c1 complex subunit 8 [KO:K00418]
104980133  cytochrome b-c1 complex subunit 9 [KO:K00419]
104991884  cytochrome b-c1 complex subunit 10 [KO:K00420]
104989916  cytochrome c oxidase subunit 4 isoform 2, mitochondrial [KO:K02263]
104996547  cytochrome c oxidase subunit 4 isoform 1, mitochondrial [KO:K02263]
104990981  cytochrome c oxidase subunit 5A, mitochondrial [KO:K02264]
104980817  cytochrome c oxidase subunit 5B, mitochondrial [KO:K02265]
104980053  cytochrome c oxidase subunit 6A1, mitochondrial [KO:K02266]
104986689  cytochrome c oxidase subunit 6A2, mitochondrial [KO:K02266]
105004715  cytochrome c oxidase subunit 6B1-like [KO:K02267]
104994988  cytochrome c oxidase subunit 6B2 [KO:K02267]
104995249  cytochrome c oxidase subunit 6B1 [KO:K02267]
105005500  cytochrome c oxidase subunit 6C [KO:K02268]
104999701  cytochrome c oxidase subunit 7A2, mitochondrial [KO:K02270]
104995277  cytochrome c oxidase subunit 7A1, mitochondrial [KO:K02270]
104990309  cytochrome c oxidase subunit 7A-related protein, mitochondrial [KO:K02270]
104985374  cytochrome c oxidase subunit 7A-related protein, mitochondrial [KO:K02270]
104992608  cytochrome c oxidase subunit 7B, mitochondrial [KO:K02271]
104995784  cytochrome c oxidase subunit 7B, mitochondrial-like [KO:K02271]
105002319  cytochrome c oxidase subunit 7B2, mitochondrial [KO:K02271]
104994451  cytochrome c oxidase subunit 7C, mitochondrial [KO:K02272]
104982497  cytochrome c oxidase subunit 7C, mitochondrial [KO:K02272]
105002443  cytochrome c oxidase subunit 7C, mitochondrial [KO:K02272]
105003933  cytochrome c oxidase subunit 7C, mitochondrial [KO:K02272]
104987180  cytochrome c oxidase subunit 8A, mitochondrial [KO:K02273]
104990096  ATP5A1; ATP synthase subunit alpha, mitochondrial [KO:K02132]
104988090  ATP5B; ATP synthase subunit beta, mitochondrial [KO:K02133] [EC:7.1.2.2]
104998122  ATP5C1; ATP synthase subunit gamma, mitochondrial isoform X1 [KO:K02136]
104991898  ATP5D; ATP synthase subunit delta, mitochondrial [KO:K02134]
104988011  ATP5E; ATP synthase subunit epsilon, mitochondrial [KO:K02135]
105001340  ATP synthase subunit epsilon, mitochondrial-like [KO:K02135]
104981633  ATP5F1; ATP synthase F(0) complex subunit B1, mitochondrial [KO:K02127]
104982380  LOW QUALITY PROTEIN: uncharacterized protein LOC104982380 [KO:K02128]
105001728  ATP5G2; ATP synthase F(0) complex subunit C2, mitochondrial [KO:K02128]
104983594  ATP synthase F(0) complex subunit C2, mitochondrial [KO:K02128]
104990591  ATP5G1; ATP synthase F(0) complex subunit C1, mitochondrial [KO:K02128]
105002940  ATP5G3; ATP synthase F(0) complex subunit C3, mitochondrial [KO:K02128]
105000333  ATP5H; ATP synthase subunit d, mitochondrial [KO:K02138]
105004610  ATP5O; ATP synthase subunit O, mitochondrial [KO:K02137]
104987493  ATP5J; ATP synthase-coupling factor 6, mitochondrial [KO:K02131]
104991863  VDAC1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
104984074  TOMM40L; mitochondrial import receptor subunit TOM40B [KO:K11518]
104997769  TOMM40; mitochondrial import receptor subunit TOM40 homolog [KO:K11518]
104997490  MCU; calcium uniporter protein, mitochondrial [KO:K20858]
104981228  PINK1; serine/threonine-protein kinase PINK1, mitochondrial [KO:K05688] [EC:2.7.11.1]
104986252  PARK2; E3 ubiquitin-protein ligase parkin isoform X1 [KO:K04556] [EC:2.3.2.31]
105003018  OPTN; optineurin isoform X1 [KO:K19946]
104981529  SQSTM1; sequestosome-1 [KO:K14381]
104986209  MAP1LC3C; microtubule-associated proteins 1A/1B light chain 3C [KO:K10435]
104999438  MAP1LC3A; microtubule-associated proteins 1A/1B light chain 3A [KO:K10435]
104996554  MAP1LC3B; microtubule-associated proteins 1A/1B light chain 3B [KO:K10435]
104997113  microtubule-associated proteins 1A/1B light chain 3B [KO:K10435]
104989798  TBK1; serine/threonine-protein kinase TBK1 [KO:K05410] [EC:2.7.11.10]
105002394  TANK; TRAF family member-associated NF-kappa-B activator isoform X1 [KO:K12650]
104994150  WDR41; WD repeat-containing protein 41 isoform X1 [KO:K23610]
104990669  SMCR8; smith-Magenis syndrome chromosomal region candidate gene 8 protein [KO:K23611]
104998259  protein C9orf72 homolog [KO:K23609]
104992643  RAB8A; ras-related protein Rab-8A [KO:K07901]
105005350  RAB1A; ras-related protein Rab-1A [KO:K07874]
104995846  MTOR; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
104997628  ULK1; LOW QUALITY PROTEIN: serine/threonine-protein kinase ULK1 [KO:K21357] [EC:2.7.11.1]
104990680  ULK2; serine/threonine-protein kinase ULK2 isoform X1 [KO:K08269] [EC:2.7.11.1]
105001537  ATG101; autophagy-related protein 101 [KO:K19730]
104990339  ATG13; autophagy-related protein 13 isoform X1 [KO:K08331]
104987864  RB1CC1; RB1-inducible coiled-coil protein 1 isoform X1 [KO:K17589]
104990387  AMBRA1; activating molecule in BECN1-regulated autophagy protein 1 [KO:K17985]
104986246  beclin-2-like [KO:K08334]
104990423  BECN1; beclin-1 [KO:K08334]
105000745  PIK3R4; phosphoinositide 3-kinase regulatory subunit 4 isoform X1 [KO:K08333] [EC:2.7.11.1]
104994208  ATG14; beclin 1-associated autophagy-related key regulator [KO:K17889]
105001232  NRBF2; nuclear receptor-binding factor 2 isoform X1 [KO:K21246]
104993281  PIK3C3; phosphatidylinositol 3-kinase catalytic subunit type 3 isoform X1 [KO:K00914] [EC:2.7.1.137]
104987201  ATG2A; autophagy-related protein 2 homolog A [KO:K17906]
104996976  ATG2B; autophagy-related protein 2 homolog B [KO:K17906]
104992811  WIPI2; WD repeat domain phosphoinositide-interacting protein 2 [KO:K17908]
105000527  WIPI1; WD repeat domain phosphoinositide-interacting protein 1 [KO:K17908]
105003662  ALS2; alsin isoform X1 [KO:K04575]
105000723  RAB5A; ras-related protein Rab-5A [KO:K07887]
104992794  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
104999298  CHMP2B; charged multivesicular body protein 2b isoform X1 [KO:K12192]
105000658  FIG4; polyphosphoinositide phosphatase [KO:K22913] [EC:3.1.3.-]
104992327  SPG11; spatacsin [KO:K19026]
104992549  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
104994644  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform [KO:K04348] [EC:3.1.3.16]
104997505  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
104992083  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
104992445  PPP3R1; calcineurin subunit B type 1 [KO:K06268]
104987476  UBQLN4; ubiquilin-4 [KO:K04523]
104988673  UBQLN1; ubiquilin-1 [KO:K04523]
104990704  UBQLN2; ubiquilin-2 [KO:K04523]
105003294  UBQLN3; ubiquilin-3 [KO:K04523]
104993030  VCP; transitional endoplasmic reticulum ATPase [KO:K13525]
104987846  DERL1; derlin-1 [KO:K11519]
104985236  PSMA6; proteasome subunit alpha type-6 [KO:K02730] [EC:3.4.25.1]
104980390  PSMA2; proteasome subunit alpha type-2 [KO:K02726] [EC:3.4.25.1]
104990948  PSMA4; proteasome subunit alpha type-4 [KO:K02728] [EC:3.4.25.1]
104991349  proteasome subunit alpha type-4-like [KO:K02728] [EC:3.4.25.1]
105003719  proteasome subunit alpha type-4-like [KO:K02728] [EC:3.4.25.1]
104980304  PSMA8; proteasome subunit alpha type-7-like [KO:K02731] [EC:3.4.25.1]
104990032  PSMA7; proteasome subunit alpha type-7 [KO:K02731] [EC:3.4.25.1]
104981678  PSMA5; proteasome subunit alpha type-5 [KO:K02729] [EC:3.4.25.1]
104981450  PSMA1; proteasome subunit alpha type-1 [KO:K02725] [EC:3.4.25.1]
104994194  PSMA3; proteasome subunit alpha type-3 [KO:K02727] [EC:3.4.25.1]
104993959  PSMB6; proteasome subunit beta type-6 [KO:K02738] [EC:3.4.25.1]
104991532  PSMB7; proteasome subunit beta type-7 [KO:K02739] [EC:3.4.25.1]
104990557  PSMB3; proteasome subunit beta type-3 [KO:K02735] [EC:3.4.25.1]
104989501  PSMB2; proteasome subunit beta type-2 [KO:K02734] [EC:3.4.25.1]
104981995  PSMB5; proteasome subunit beta type-5 [KO:K02737] [EC:3.4.25.1]
104994848  PSMB1; proteasome subunit beta type-1 [KO:K02732] [EC:3.4.25.1]
105001305  PSMB4; proteasome subunit beta type-4 [KO:K02736] [EC:3.4.25.1]
104994485  PSMC2; 26S protease regulatory subunit 7 [KO:K03061]
104992320  PSMC1; 26S protease regulatory subunit 4 [KO:K03062]
104995353  PSMC4; 26S protease regulatory subunit 6B [KO:K03063]
104984704  PSMC6; 26S protease regulatory subunit 10B [KO:K03064]
104990355  PSMC3; 26S protease regulatory subunit 6A [KO:K03065]
105000499  PSMC5; 26S protease regulatory subunit 8 [KO:K03066]
105000026  PSMD2; 26S proteasome non-ATPase regulatory subunit 2 [KO:K03028]
104986501  PSMD1; 26S proteasome non-ATPase regulatory subunit 1 [KO:K03032]
104990520  PSMD3; 26S proteasome non-ATPase regulatory subunit 3 [KO:K03033]
104989607  PSMD9; 26S proteasome non-ATPase regulatory subunit 9 [KO:K06693]
105000475  PSMD12; 26S proteasome non-ATPase regulatory subunit 12 [KO:K03035]
105003989  PSMD11; 26S proteasome non-ATPase regulatory subunit 11 [KO:K03036]
104997061  PSMD6; 26S proteasome non-ATPase regulatory subunit 6 [KO:K03037]
104996646  PSMD7; 26S proteasome non-ATPase regulatory subunit 7 [KO:K03038]
104983501  PSMD13; 26S proteasome non-ATPase regulatory subunit 13 [KO:K03039]
105001311  PSMD4; 26S proteasome non-ATPase regulatory subunit 4 [KO:K03029]
105002391  PSMD14; 26S proteasome non-ATPase regulatory subunit 14 isoform X1 [KO:K03030]
104995311  PSMD8; LOW QUALITY PROTEIN: 26S proteasome non-ATPase regulatory subunit 8 [KO:K03031]
104989993  ADRM1; proteasomal ubiquitin receptor ADRM1 [KO:K06691]
104991762  HDAC6; LOW QUALITY PROTEIN: histone deacetylase 6 [KO:K11407] [EC:3.5.1.98]
104995850  TARDBP; TAR DNA-binding protein 43 [KO:K23600]
104986685  FUS; RNA-binding protein FUS isoform X1 [KO:K13098]
104998494  heterogeneous nuclear ribonucleoprotein A1-like [KO:K12741]
105004904  heterogeneous nuclear ribonucleoprotein A3 [KO:K12741]
104995018  putative heterogeneous nuclear ribonucleoprotein A1-like 3 [KO:K12741]
105001605  HNRNPA1; heterogeneous nuclear ribonucleoprotein A1 isoform X1 [KO:K12741]
104989999  heterogeneous nuclear ribonucleoprotein A1-like [KO:K12741]
105002929  HNRNPA3; heterogeneous nuclear ribonucleoprotein A3 isoform X1 [KO:K12741]
104979949  heterogeneous nuclear ribonucleoproteins A2/B1-like [KO:K13158]
104999780  HNRNPA2B1; heterogeneous nuclear ribonucleoproteins A2/B1 isoform X1 [KO:K13158]
104986614  ATXN2L; ataxin-2-like protein isoform X1 [KO:K23625]
104989683  ATXN2; ataxin-2 [KO:K23625]
104996179  MATR3; LOW QUALITY PROTEIN: matrin-3 [KO:K13213]
104981627  angiogenin-1 [KO:K16631] [EC:3.1.27.-]
104988196  ANG; angiogenin [KO:K16631] [EC:3.1.27.-]
104988219  angiogenin-1-like [KO:K16631] [EC:3.1.27.-]
104993698  NCBP1; nuclear cap-binding protein subunit 1 [KO:K12882]
105000589  ALYREF; THO complex subunit 4 [KO:K12881]
104994947  SRSF3; serine/arginine-rich splicing factor 3 [KO:K12892]
104995490  serine/arginine-rich splicing factor 3-like [KO:K12892]
104999946  SRSF7; serine/arginine-rich splicing factor 7 isoform X1 [KO:K12896]
104998673  NXF1; nuclear RNA export factor 1 [KO:K14284]
104987828  nuclear RNA export factor 3-like [KO:K14284]
105000909  LOW QUALITY PROTEIN: nuclear RNA export factor 3-like [KO:K14284]
104983070  LOW QUALITY PROTEIN: nuclear RNA export factor 3-like [KO:K14284]
105001872  nuclear RNA export factor 2-like [KO:K14284]
104985956  NXT1; NTF2-related export protein 1 [KO:K14285]
105000816  GLE1; nucleoporin GLE1 [KO:K18723]
104998060  TPR; nucleoprotein TPR [KO:K09291]
104986896  NUP50; nuclear pore complex protein Nup50 [KO:K14295]
104995095  NUP153; nuclear pore complex protein Nup153 [KO:K14296]
104995553  NUP98; nuclear pore complex protein Nup98-Nup96 isoform X1 [KO:K14297]
104989960  RAE1; mRNA export factor [KO:K14298]
105004723  SEC13; protein SEC13 homolog [KO:K14004]
105002477  SEH1L; nucleoporin SEH1 [KO:K14299]
104987267  NUP133; nuclear pore complex protein Nup133 [KO:K14300]
104989773  NUP107; nuclear pore complex protein Nup107 isoform X1 [KO:K14301]
104998323  NUP37; nucleoporin Nup37 [KO:K14302]
104990364  NUP160; nuclear pore complex protein Nup160 [KO:K14303]
105000340  NUP85; nuclear pore complex protein Nup85 isoform X1 [KO:K14304]
105004810  NUP43; nucleoporin Nup43 [KO:K14305]
104995739  NUP62; nuclear pore glycoprotein p62 [KO:K14306]
104996861  NUPL1; nucleoporin p58/p45 [KO:K14307]
104987290  NUP54; nucleoporin p54 [KO:K14308]
105004316  NUP93; nuclear pore complex protein Nup93 isoform X1 [KO:K14309]
104982286  NUP205; nuclear pore complex protein Nup205 [KO:K14310]
105000892  NUP188; nucleoporin NUP188 homolog [KO:K14311]
104998546  NUP155; nuclear pore complex protein Nup155 [KO:K14312]
105002898  NUP35; nucleoporin NUP53 [KO:K14313]
105004800  NUP210; LOW QUALITY PROTEIN: nuclear pore membrane glycoprotein 210 [KO:K14314]
104987446  NUP210L; nuclear pore membrane glycoprotein 210-like [KO:K14314]
104993763  NDC1; nucleoporin NDC1 [KO:K14315]
104998913  POM121C; nuclear envelope pore membrane protein POM 121C isoform X1 [KO:K14316]
104984342  POM121L2; POM121-like protein 2 [KO:K14316]
105000785  NUP214; nuclear pore complex protein Nup214 isoform X1 [KO:K14317]
104993976  NUP88; nuclear pore complex protein Nup88 isoform X1 [KO:K14318]
105005116  RANBP2; E3 SUMO-protein ligase RanBP2 isoform X1 [KO:K12172] [EC:2.3.2.-]
105000777  SETX; probable helicase senataxin isoform X1 [KO:K10706] [EC:5.6.2.5 5.6.2.3]
104989854  coiled-coil-helix-coiled-coil-helix domain-containing protein 10, mitochondrial-like [KO:K22759]
104991546  HSPA5; 78 kDa glucose-regulated protein [KO:K09490] [EC:3.6.4.10]
104990024  VAPB; vesicle-associated membrane protein-associated protein B/C [KO:K10707]
104999179  ATF6; cyclic AMP-dependent transcription factor ATF-6 alpha isoform X1 [KO:K09054]
104988119  DDIT3; DNA damage-inducible transcript 3 protein [KO:K04452]
105000492  ERN1; serine/threonine-protein kinase/endoribonuclease IRE1 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
104980220  XBP1; X-box-binding protein 1 [KO:K09027]
104982944  TRAF2; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
104991715  MAP3K5; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
104984424  EIF2AK3; eukaryotic translation initiation factor 2-alpha kinase 3 [KO:K08860] [EC:2.7.11.1]
104993460  EIF2S1; eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
104984118  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
104995001  ITPR3; LOW QUALITY PROTEIN: inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
104988686  SIGMAR1; sigma non-opioid intracellular receptor 1 [KO:K20719]
104983770  TNF; tumor necrosis factor isoform X1 [KO:K03156]
104992338  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
104995825  TNFRSF1B; tumor necrosis factor receptor superfamily member 1B [KO:K05141]
104994997  DAXX; death domain-associated protein 6 [KO:K02308]
104990647  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 [KO:K04432] [EC:2.7.12.2]
105000295  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 isoform X1 [KO:K04433] [EC:2.7.12.2]
104981967  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
104981977  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
104994938  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
104994939  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
104980001  NOS1; nitric oxide synthase, brain isoform X1 [KO:K13240] [EC:1.14.13.39]
104986988  CCS; copper chaperone for superoxide dismutase isoform X1 [KO:K04569]
104993475  GPX2; LOW QUALITY PROTEIN: glutathione peroxidase 2 [KO:K00432] [EC:1.11.1.9]
104993800  GPX7; glutathione peroxidase 7 [KO:K00432] [EC:1.11.1.9]
105001042  GPX8; probable glutathione peroxidase 8 [KO:K00432] [EC:1.11.1.9]
105001151  GPX5; epididymal secretory glutathione peroxidase [KO:K00432] [EC:1.11.1.9]
105001152  GPX6; LOW QUALITY PROTEIN: glutathione peroxidase 6 [KO:K00432] [EC:1.11.1.9]
104996331  GPX3; LOW QUALITY PROTEIN: glutathione peroxidase 3 [KO:K00432] [EC:1.11.1.9]
104997210  GPX1; glutathione peroxidase 1 [KO:K00432] [EC:1.11.1.9]
104982462  CAT; catalase [KO:K03781] [EC:1.11.1.6]
105001693  PRPH; peripherin [KO:K07607]
104988736  NEFL; neurofilament light polypeptide [KO:K04572]
104988737  NEFM; neurofilament medium polypeptide [KO:K04573]
104980126  NEFH; neurofilament heavy polypeptide [KO:K04574]
104993331  PFN3; profilin-3 [KO:K05759]
104993965  PFN1; profilin-1 [KO:K05759]
104994818  profilin-2-like [KO:K05759]
104989025  PFN4; profilin-4 isoform X1 [KO:K05759]
105001836  PFN2; profilin-2 [KO:K05759]
104992781  ACTB; actin, cytoplasmic 1 [KO:K05692]
105000428  ACTG1; LOW QUALITY PROTEIN: actin, cytoplasmic 2 [KO:K05692]
104984454  ANXA11; annexin A11 [KO:K17095]
104997504  ANXA7; annexin A7 isoform X1 [KO:K17095]
104988125  KIF5A; kinesin heavy chain isoform 5A [KO:K10396]
104988606  KIF5C; kinesin heavy chain isoform 5C isoform X1 [KO:K10396]
105003056  KIF5B; kinesin-1 heavy chain isoform X1 [KO:K10396]
105005223  KLC4; kinesin light chain 4 [KO:K10407]
104987077  KLC2; kinesin light chain 2 [KO:K10407]
104996921  KLC1; kinesin light chain 1 isoform X1 [KO:K10407]
104997696  KLC3; kinesin light chain 3 [KO:K10407]
104986157  TUBAL3; tubulin alpha chain-like 3 [KO:K07374]
104992261  TUBA8; tubulin alpha-8 chain [KO:K07374]
104998531  tubulin alpha-1C chain [KO:K07374]
104993381  TUBA3E; tubulin alpha-3E chain [KO:K07374]
104994750  tubulin alpha-1A chain-like [KO:K07374]
105001471  TUBA1B; tubulin alpha-1B chain [KO:K07374]
105001472  TUBA1A; tubulin alpha-1A chain [KO:K07374]
104984835  tubulin alpha-3 chain-like [KO:K07374]
104984854  tubulin alpha-3 chain-like [KO:K07374]
105003795  tubulin alpha-4A chain [KO:K07374]
105003796  tubulin alpha-1D chain [KO:K07374]
104979917  TUBB4A; tubulin beta-4A chain [KO:K07375]
104994526  tubulin beta-7 chain [KO:K07375]
104983318  tubulin beta-2A chain-like [KO:K07375]
104983319  tubulin beta-2 chain-like [KO:K07375]
104989926  tubulin beta chain-like [KO:K07375]
104989979  TUBB1; tubulin beta-1 chain [KO:K07375]
105002478  TUBB6; tubulin beta-6 chain [KO:K07375]
104991455  TUBB3; tubulin beta-3 chain isoform X1 [KO:K07375]
104980894  DCTN1; dynactin subunit 1 isoform X1 [KO:K04648]
104988124  DCTN2; dynactin subunit 2 isoform X1 [KO:K10424]
105002308  dynactin subunit 2 [KO:K10424]
104988687  DCTN3; dynactin subunit 3 isoform X1 [KO:K10425]
104996325  DCTN4; dynactin subunit 4 [KO:K10426]
104986583  DCTN5; dynactin subunit 5 [KO:K10427]
104987759  DCTN6; dynactin subunit 6 [KO:K10428]
104980818  ACTR1B; beta-centractin isoform X1 [KO:K16575]
105002674  ACTR1A; alpha-centractin [KO:K16575]
104994257  ACTR10; actin-related protein 10 [KO:K16576]
104990460  HAP1; LOW QUALITY PROTEIN: huntingtin-associated protein 1 [KO:K04647]
104997955  DNAH14; dynein heavy chain 14, axonemal [KO:K10408]
105004547  DNAH6; dynein heavy chain 6, axonemal [KO:K10408]
104986727  DNAH3; dynein heavy chain 3, axonemal [KO:K10408]
104987931  DNAH11; dynein heavy chain 11, axonemal [KO:K10408]
105000568  DNAH17; dynein heavy chain 17, axonemal [KO:K10408]
104994971  DNAH8; dynein heavy chain 8, axonemal [KO:K10408]
104989666  DNAH10; dynein heavy chain 10, axonemal [KO:K10408]
105002261  DNAH5; dynein heavy chain 5, axonemal [KO:K10408]
104990711  DNAH9; dynein heavy chain 9, axonemal isoform X1 [KO:K10408]
104990896  DNAH2; dynein heavy chain 2, axonemal [KO:K10408]
104997095  DNAH12; dynein heavy chain 12, axonemal isoform X1 [KO:K10408]
104997140  DNAH1; dynein heavy chain 1, axonemal [KO:K10408]
105003604  DNAH7; dynein heavy chain 7, axonemal [KO:K10408]
105004957  DNALI1; axonemal dynein light intermediate polypeptide 1 [KO:K10410]
104988692  DNAI1; dynein intermediate chain 1, axonemal [KO:K10409]
105000311  DNAI2; dynein intermediate chain 2, axonemal [KO:K11143]
105000094  DNAL1; dynein light chain 1, axonemal [KO:K10411]
104992293  DNAL4; dynein light chain 4, axonemal [KO:K10412]
104982470  SLC1A2; excitatory amino acid transporter 2 isoform X1 [KO:K05613]
105003971  NOS2; nitric oxide synthase, inducible [KO:K13241] [EC:1.14.13.39]
104980611  GRIA1; glutamate receptor 1 isoform X1 [KO:K05197]
104985749  GRIA2; glutamate receptor 2 isoform X1 [KO:K05198]
104985586  GRIN1; LOW QUALITY PROTEIN: glutamate receptor ionotropic, NMDA 1 [KO:K05208]
104996405  GRIN2A; glutamate receptor ionotropic, NMDA 2A isoform X1 [KO:K05209]
105002184  GRIN2B; glutamate receptor ionotropic, NMDA 2B [KO:K05210]
105000537  GRIN2C; glutamate receptor ionotropic, NMDA 2C [KO:K05211]
104995715  GRIN2D; LOW QUALITY PROTEIN: glutamate receptor ionotropic, NMDA 2D [KO:K05212]
104996350  NRG2; pro-neuregulin-2, membrane-bound isoform [KO:K05456]
104984464  uncharacterized protein LOC104984464 [KO:K05457]
104990954  NRG4; pro-neuregulin-4, membrane-bound isoform [KO:K05458]
105003731  ERBB4; LOW QUALITY PROTEIN: receptor tyrosine-protein kinase erbB-4 [KO:K05085] [EC:2.7.10.1]
Compound
C00001  H2O
C00008  ADP
C00025  L-Glutamate
C00027  Hydrogen peroxide
C00039  DNA
C00046  RNA
C00062  L-Arginine
C00070  Copper
C00076  Calcium cation
C00533  Nitric oxide
C00704  Superoxide
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C16844  Hydroxyl radical
C16845  Peroxynitrite
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Related
pathway
bbis00190  Oxidative phosphorylation
bbis03013  Nucleocytoplasmic transport
bbis03050  Proteasome
bbis04010  MAPK signaling pathway
bbis04012  ErbB signaling pathway
bbis04020  Calcium signaling pathway
bbis04115  p53 signaling pathway
bbis04137  Mitophagy - animal
bbis04140  Autophagy - animal
bbis04141  Protein processing in endoplasmic reticulum
bbis04210  Apoptosis
bbis04724  Glutamatergic synapse
bbis04810  Regulation of actin cytoskeleton
KO pathway
ko05014   
LinkDB

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