Entry Name Rap1 signaling pathway - Bos indicus (zebu cattle)
Description Rap1 is a small GTPase that controls diverse processes, such as cell adhesion, cell-cell junction formation and cell polarity. Like all G proteins, Rap1 cycles between an inactive GDP-bound and an active GTP-bound conformation. A variety of extracellular signals control this cycle through the regulation of several unique guanine nucleotide exchange factors (GEFs) and GTPase activating proteins (GAPs). Rap1 plays a dominant role in the control of cell-cell and cell-matrix interactions by regulating the function of integrins and other adhesion molecules in various cell types. Rap1 also regulates MAP kinase (MAPK) activity in a manner highly dependent on the context of cell types.
Class Environmental Information Processing; Signal transductionBRITE hierarchy
Pathway map Ortholog table Other DBs Organism Bos indicus (zebu cattle) [GN:
biu ]
Gene 109557298 RAPGEF5; rap guanine nucleotide exchange factor 5 isoform X1 [KO:K08019 ]
109570679 CALML6; LOW QUALITY PROTEIN: calmodulin-like protein 6 [KO:K02183 ]
109567291 guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas-like [KO:K04632 ]
109559177 RAPGEF3; rap guanine nucleotide exchange factor 3 isoform X1 [KO:K08014 ]
109566435 RAPGEF4; rap guanine nucleotide exchange factor 4 isoform X1 [KO:K04351 ]
109562978 GNAQ; guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634 ]
109567852 PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858 ] [EC:3.1.4.11 ]
109567854 PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858 ] [EC:3.1.4.11 ]
109564927 PLCB2; LOW QUALITY PROTEIN: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858 ] [EC:3.1.4.11 ]
109554125 LOW QUALITY PROTEIN: RAS guanyl-releasing protein 2-like [KO:K12361 ]
109559983 EGF; LOW QUALITY PROTEIN: pro-epidermal growth factor [KO:K04357 ]
109570879 FGF2; LOW QUALITY PROTEIN: fibroblast growth factor 2 [KO:K18497 ]
109578611 PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359 ]
109558630 LOW QUALITY PROTEIN: platelet-derived growth factor subunit B-like [KO:K17386 ]
109555962 CSF1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453 ]
109576576 VEGFA; LOW QUALITY PROTEIN: vascular endothelial growth factor A [KO:K05448 ]
109555471 VEGFD; vascular endothelial growth factor D isoform X1 [KO:K05449 ]
109574393 NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583 ]
109566561 RAPGEF1; rap guanine nucleotide exchange factor 1 isoform X1 [KO:K06277 ]
109572528 BCAR1; breast cancer anti-estrogen resistance protein 1 [KO:K05726 ]
109576115 MAGI1; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X1 [KO:K05631 ]
109555908 MAGI3; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 3 isoform X1 [KO:K06112 ]
109578681 LAT; linker for activation of T-cells family member 1 isoform X1 [KO:K07362 ]
109574127 SKAP1; src kinase-associated phosphoprotein 1 isoform X1 [KO:K17699 ]
109557337 GNAI1; guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630 ]
109576257 GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630 ]
109555970 GNAI3; guanine nucleotide-binding protein G(k) subunit alpha [KO:K04630 ]
109572786 GNAO1; guanine nucleotide-binding protein G(o) subunit alpha isoform X1 [KO:K04534 ]
109565307 signal-induced proliferation-associated 1-like protein 1 [KO:K17701 ]
109565308 signal-induced proliferation-associated 1-like protein 1 isoform X1 [KO:K17701 ]
109554393 SIPA1; LOW QUALITY PROTEIN: signal-induced proliferation-associated protein 1 [KO:K08013 ]
109553846 SIPA1L2; signal-induced proliferation-associated 1-like protein 2 isoform X1 [KO:K17702 ]
109571709 SIPA1L3; signal-induced proliferation-associated 1-like protein 3 [KO:K17703 ]
109565671 RALGDS; ral guanine nucleotide dissociation stimulator [KO:K08732 ]
109567912 APBB1IP; amyloid beta A4 precursor protein-binding family B member 1-interacting protein [KO:K17704 ]
109561086 ARAP3; LOW QUALITY PROTEIN: arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 [KO:K12490 ]
109565687 VAV2; LOW QUALITY PROTEIN: guanine nucleotide exchange factor VAV2 [KO:K05730 ]
109562052 TIAM1; T-lymphoma invasion and metastasis-inducing protein 1 [KO:K05731 ]
109572619 PARD6A; partitioning defective 6 homolog alpha isoform X1 [KO:K06093 ]
109570657 RASSF5; ras association domain-containing protein 5 isoform X1 [KO:K08015 ]
109559805 PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922 ] [EC:2.7.1.153 ]
109570415 PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922 ] [EC:2.7.1.153 ]
109557823 PIK3CA; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922 ] [EC:2.7.1.153 ]
109574805 PIK3R1; LOW QUALITY PROTEIN: phosphatidylinositol 3-kinase regulatory subunit alpha [KO:K02649 ]
109561418 PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649 ]
109556345 phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649 ]
109553155 PLCE1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X1 [KO:K05860 ] [EC:3.1.4.11 ]
Compound Reference Authors Kooistra MR, Dube N, Bos JL
Title Rap1: a key regulator in cell-cell junction formation.
Journal Reference Authors Bos JL, de Rooij J, Reedquist KA
Title Rap1 signalling: adhering to new models.
Journal Reference Authors Minato N, Kometani K, Hattori M
Title Regulation of immune responses and hematopoiesis by the Rap1 signal.
Journal Reference Authors Bos JL
Title Linking Rap to cell adhesion.
Journal Reference Authors Caron E
Title Cellular functions of the Rap1 GTP-binding protein: a pattern emerges.
Journal Reference Authors Zwartkruis FJ, Bos JL
Title Ras and Rap1: two highly related small GTPases with distinct function.
Journal Reference Authors Hattori M, Minato N
Title Rap1 GTPase: functions, regulation, and malignancy.
Journal Reference Authors Pannekoek WJ, Kooistra MR, Zwartkruis FJ, Bos JL
Title Cell-cell junction formation: the role of Rap1 and Rap1 guanine nucleotide exchange factors.
Journal Reference Authors Boettner B, Van Aelst L
Title Control of cell adhesion dynamics by Rap1 signaling.
Journal Reference Authors Xia Z, Storm DR.
Title The role of calmodulin as a signal integrator for synaptic plasticity.
Journal Reference Authors Mor A, Dustin ML, Philips MR
Title Small GTPases and LFA-1 reciprocally modulate adhesion and signaling.
Journal Reference Authors Burbach BJ, Medeiros RB, Mueller KL, Shimizu Y
Title T-cell receptor signaling to integrins.
Journal Reference Authors Stork PJ
Title Does Rap1 deserve a bad Rap?
Journal Reference Authors Banihashemi B, Albert PR
Title Dopamine-D2S receptor inhibition of calcium influx, adenylyl cyclase, and mitogen-activated protein kinase in pituitary cells: distinct Galpha and Gbetagamma requirements.
Journal Reference Authors Banno A, Ginsberg MH
Title Integrin activation.
Journal Reference Authors Doebele RC, Schulze-Hoepfner FT, Hong J, Chlenski A, Zeitlin BD, Goel K, Gomes S, Liu Y, Abe MK, Nor JE, Lingen MW, Rosner MR
Title A novel interplay between Epac/Rap1 and mitogen-activated protein kinase kinase 5/extracellular signal-regulated kinase 5 (MEK5/ERK5) regulates thrombospondin to control angiogenesis.
Journal Reference Authors Breckler M, Berthouze M, Laurent AC, Crozatier B, Morel E, Lezoualc'h F
Title Rap-linked cAMP signaling Epac proteins: compartmentation, functioning and disease implications.
Journal Related biu04660 T cell receptor signaling pathway
biu04810 Regulation of actin cytoskeleton
KO pathway LinkDB All DBs
