Entry
Name
Rap1 signaling pathway - Dipodomys spectabilis (banner-tailed kangaroo rat)
Description
Rap1 is a small GTPase that controls diverse processes, such as cell adhesion, cell-cell junction formation and cell polarity. Like all G proteins, Rap1 cycles between an inactive GDP-bound and an active GTP-bound conformation. A variety of extracellular signals control this cycle through the regulation of several unique guanine nucleotide exchange factors (GEFs) and GTPase activating proteins (GAPs). Rap1 plays a dominant role in the control of cell-cell and cell-matrix interactions by regulating the function of integrins and other adhesion molecules in various cell types. Rap1 also regulates MAP kinase (MAPK) activity in a manner highly dependent on the context of cell types.
Class
Environmental Information Processing; Signal transduction
BRITE hierarchy
Pathway map
Ortholog table
Other DBs
Organism
Dipodomys spectabilis (banner-tailed kangaroo rat) [GN:
dsp ]
Gene
122112132 Rapgef5; rap guanine nucleotide exchange factor 5 isoform X1 [KO:K08019 ]
122102555 Grin1; glutamate receptor ionotropic, NMDA 1 isoform X1 [KO:K05208 ]
122124612 guanine nucleotide-binding protein G(s) subunit alpha isoform X1 [KO:K04632 ]
122106262 Rapgef3; rap guanine nucleotide exchange factor 3 isoform X1 [KO:K08014 ]
122120106 Rapgef4; rap guanine nucleotide exchange factor 4 isoform X1 [KO:K04351 ]
122095118 Gnaq; guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634 ]
122120299 Plcb1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858 ] [EC:3.1.4.11 ]
122114401 Plcb2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858 ] [EC:3.1.4.11 ]
122102809 Fgf6; LOW QUALITY PROTEIN: fibroblast growth factor 6 [KO:K04358 ]
122113621 Pdgfa; platelet-derived growth factor subunit A isoform X1 [KO:K04359 ]
122109178 Csf1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453 ]
122104926 Vegfb; vascular endothelial growth factor B isoform X1 [KO:K16858 ]
122103503 Ngfr; tumor necrosis factor receptor superfamily member 16 [KO:K02583 ]
122108897 Rapgef1; rap guanine nucleotide exchange factor 1 isoform X1 [KO:K06277 ]
122126159 Bcar1; breast cancer anti-estrogen resistance protein 1 isoform X1 [KO:K05726 ]
122108039 Magi1; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X1 [KO:K05631 ]
122111802 Magi2; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 [KO:K05629 ]
122118344 Magi3; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 3 [KO:K06112 ]
122097797 Rapgef2; rap guanine nucleotide exchange factor 2 isoform X1 [KO:K08018 ]
122115372 Rapgef6; rap guanine nucleotide exchange factor 6 isoform X1 [KO:K08020 ]
122096304 Lat; linker for activation of T-cells family member 1 [KO:K07362 ]
122095572 Gnai2; guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630 ]
122111882 Gnai1; guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630 ]
122105366 Gnai3; guanine nucleotide-binding protein G(i) subunit alpha-3 [KO:K04630 ]
122116328 Gnao1; guanine nucleotide-binding protein G(o) subunit alpha isoform X1 [KO:K04534 ]
122118790 Sipa1l1; signal-induced proliferation-associated 1-like protein 1 isoform X1 [KO:K17701 ]
122104975 Sipa1; signal-induced proliferation-associated protein 1 isoform X1 [KO:K08013 ]
122113252 Sipa1l2; signal-induced proliferation-associated 1-like protein 2 isoform X1 [KO:K17702 ]
122097616 Sipa1l3; signal-induced proliferation-associated 1-like protein 3 isoform X1 [KO:K17703 ]
122114847 LOW QUALITY PROTEIN: ral guanine nucleotide dissociation stimulator-like [KO:K08732 ]
122109018 Ralgds; ral guanine nucleotide dissociation stimulator isoform X1 [KO:K08732 ]
122113510 Rac1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392 ]
122113312 LOW QUALITY PROTEIN: amyloid beta A4 precursor protein-binding family B member 1-interacting protein [KO:K17704 ]
122118187 Arap3; arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 isoform X1 [KO:K12490 ]
122125103 Farp2; FERM, ARHGEF and pleckstrin domain-containing protein 2 [KO:K06082 ]
122104889 Vav3; guanine nucleotide exchange factor VAV3 isoform X1 [KO:K05730 ]
122108904 Vav2; guanine nucleotide exchange factor VAV2 isoform X1 [KO:K05730 ]
122109145 Rassf5; ras association domain-containing protein 5 isoform X1 [KO:K08015 ]
122095294 Pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922 ] [EC:2.7.1.153 ]
122121501 Pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922 ] [EC:2.7.1.153 ]
122107232 Pik3ca; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922 ] [EC:2.7.1.153 ]
122123339 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform-like [KO:K00922 ] [EC:2.7.1.153 ]
122108047 phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649 ]
122100872 Pik3r2; LOW QUALITY PROTEIN: phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649 ]
122117343 Pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649 ]
122115929 Plce1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X1 [KO:K05860 ] [EC:3.1.4.11 ]
Compound
Reference
Authors
Kooistra MR, Dube N, Bos JL
Title
Rap1: a key regulator in cell-cell junction formation.
Journal
Reference
Authors
Bos JL, de Rooij J, Reedquist KA
Title
Rap1 signalling: adhering to new models.
Journal
Reference
Authors
Minato N, Kometani K, Hattori M
Title
Regulation of immune responses and hematopoiesis by the Rap1 signal.
Journal
Reference
Authors
Bos JL
Title
Linking Rap to cell adhesion.
Journal
Reference
Authors
Caron E
Title
Cellular functions of the Rap1 GTP-binding protein: a pattern emerges.
Journal
Reference
Authors
Zwartkruis FJ, Bos JL
Title
Ras and Rap1: two highly related small GTPases with distinct function.
Journal
Reference
Authors
Hattori M, Minato N
Title
Rap1 GTPase: functions, regulation, and malignancy.
Journal
Reference
Authors
Pannekoek WJ, Kooistra MR, Zwartkruis FJ, Bos JL
Title
Cell-cell junction formation: the role of Rap1 and Rap1 guanine nucleotide exchange factors.
Journal
Reference
Authors
Boettner B, Van Aelst L
Title
Control of cell adhesion dynamics by Rap1 signaling.
Journal
Reference
Authors
Xia Z, Storm DR.
Title
The role of calmodulin as a signal integrator for synaptic plasticity.
Journal
Reference
Authors
Mor A, Dustin ML, Philips MR
Title
Small GTPases and LFA-1 reciprocally modulate adhesion and signaling.
Journal
Reference
Authors
Burbach BJ, Medeiros RB, Mueller KL, Shimizu Y
Title
T-cell receptor signaling to integrins.
Journal
Reference
Authors
Stork PJ
Title
Does Rap1 deserve a bad Rap?
Journal
Reference
Authors
Banihashemi B, Albert PR
Title
Dopamine-D2S receptor inhibition of calcium influx, adenylyl cyclase, and mitogen-activated protein kinase in pituitary cells: distinct Galpha and Gbetagamma requirements.
Journal
Reference
Authors
Banno A, Ginsberg MH
Title
Integrin activation.
Journal
Reference
Authors
Doebele RC, Schulze-Hoepfner FT, Hong J, Chlenski A, Zeitlin BD, Goel K, Gomes S, Liu Y, Abe MK, Nor JE, Lingen MW, Rosner MR
Title
A novel interplay between Epac/Rap1 and mitogen-activated protein kinase kinase 5/extracellular signal-regulated kinase 5 (MEK5/ERK5) regulates thrombospondin to control angiogenesis.
Journal
Reference
Authors
Breckler M, Berthouze M, Laurent AC, Crozatier B, Morel E, Lezoualc'h F
Title
Rap-linked cAMP signaling Epac proteins: compartmentation, functioning and disease implications.
Journal
Related pathway
dsp04660 T cell receptor signaling pathway
dsp04810 Regulation of actin cytoskeleton
KO pathway
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