KEGG   PATHWAY: dsp04151
Entry
dsp04151                    Pathway                                
Name
PI3K-Akt signaling pathway - Dipodomys spectabilis (banner-tailed kangaroo rat)
Description
The phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, translation, proliferation, growth, and survival. The binding of growth factors to their receptor tyrosine kinase (RTK) or G protein-coupled receptors (GPCR) stimulates class Ia and Ib PI3K isoforms, respectively. PI3K catalyzes the production of phosphatidylinositol-3,4,5-triphosphate (PIP3) at the cell membrane. PIP3 in turn serves as a second messenger that helps to activate Akt. Once active, Akt can control key cellular processes by phosphorylating substrates involved in apoptosis, protein synthesis, metabolism, and cell cycle.
Class
Environmental Information Processing; Signal transduction
Pathway map
dsp04151  PI3K-Akt signaling pathway
dsp04151

Other DBs
GO: 0043491
Organism
Dipodomys spectabilis (banner-tailed kangaroo rat) [GN:dsp]
Gene
122094922  Itgb4; integrin beta-4 [KO:K06525]
122095011  Hras; GTPase HRas isoform X1 [KO:K02833]
122095235  [KO:K03259]
122095294  Pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
122095643  Lamb2; laminin subunit beta-2 isoform X1 [KO:K06243]
122095660  Col6a6; collagen alpha-6(VI) chain [KO:K06238]
122095844  Mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
122095873  [KO:K13304] [EC:2.7.11.1]
122095937  Ywhah; 14-3-3 protein eta [KO:K16198]
122096205  Il4r; interleukin-4 receptor subunit alpha [KO:K05071]
122096287  Mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
122096300  Cd19; B-lymphocyte antigen CD19 isoform X1 [KO:K06465]
122096363  [KO:K05096] [EC:2.7.10.1]
122096494  Fgfr4; fibroblast growth factor receptor 4 isoform X1 [KO:K05095] [EC:2.7.10.1]
122096525  Eif4e1b; eukaryotic translation initiation factor 4E type 1B [KO:K03259]
122096618  Fgf17; fibroblast growth factor 17 isoform X1 [KO:K04358]
122096773  Itga9; integrin alpha-9 [KO:K06585]
122096813  Gsk3b; glycogen synthase kinase-3 beta [KO:K03083] [EC:2.7.11.26]
122097000  Mtcp1; protein p13 MTCP-1 [KO:K16837]
122097005  Ikbkg; NF-kappa-B essential modulator isoform X1 [KO:K07210]
122097174  Osm; oncostatin-M [KO:K05418]
122097244  [KO:K04659]
122097416  Akt2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
122097446  Ccne1; G1/S-specific cyclin-E1 isoform X1 [KO:K06626]
122097598  Itgb5; integrin beta-5 [KO:K06588]
122097662  Fgf16; fibroblast growth factor 16 [KO:K04358]
122097683  Lpar4; lysophosphatidic acid receptor 4 [KO:K04275]
122097855  Pdgfc; platelet-derived growth factor C [KO:K05450]
122097869  [KO:K06253]
122098058  [KO:K16340] [EC:3.1.3.16]
122098077  Col9a1; collagen alpha-1(IX) chain isoform X1 [KO:K08131]
122098417  Nr4a1; nuclear receptor subfamily 4 group A member 1 [KO:K04465]
122098841  Kras; GTPase KRas isoform X1 [KO:K07827]
122099125  Casp9; caspase-9 [KO:K04399] [EC:3.4.22.62]
122099158  Epha2; ephrin type-A receptor 2 [KO:K05103] [EC:2.7.10.1]
122099244  Gnb4; guanine nucleotide-binding protein subunit beta-4 [KO:K04538]
122099305  Gng7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543]
122099328  Creb3l3; cyclic AMP-responsive element-binding protein 3-like protein 3 [KO:K09048]
122099331  Map2k2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
122099358  Rptor; regulatory-associated protein of mTOR [KO:K07204]
122099750  Ppp2r2c; protein phosphatase 2, regulatory subunit B, gamma [KO:K04354]
122099862  Ppp2r3a; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha [KO:K11583]
122099882  Ccnd1; G1/S-specific cyclin-D1 [KO:K04503]
122099887  Fgf3; fibroblast growth factor 3 [KO:K04358]
122100019  Lama4; laminin subunit alpha-4 [KO:K06241]
122100133  Ywhae; 14-3-3 protein epsilon [KO:K06630]
122100440  Tp53; cellular tumor antigen p53 [KO:K04451]
122100605  Itga2b; integrin alpha-IIb isoform X1 [KO:K06476]
122100692  Fgfr3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
122100828  Lpar2; lysophosphatidic acid receptor 2 [KO:K04291]
122100847  [KO:K04659]
122100872  Pik3r2; LOW QUALITY PROTEIN: phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
122100890  Jak3; tyrosine-protein kinase JAK3 [KO:K11218] [EC:2.7.10.2]
122101223  [KO:K11583]
122101247  Cdkn1b; cyclin-dependent kinase inhibitor 1B [KO:K06624]
122101263  Akt1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
122101491  Ppp2r5d; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform isoform X1 [KO:K11584]
122101493  Vegfa; vascular endothelial growth factor A [KO:K05448]
122101503  Ccnd3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
122101518  Hsp90ab1; heat shock protein HSP 90-beta [KO:K04079]
122101842  Ppp2r2d; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform isoform X1 [KO:K04354]
122101870  Fgf18; fibroblast growth factor 18 [KO:K04358]
122101888  Gng13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547]
122101959  Lpar5; lysophosphatidic acid receptor 5 [KO:K08390]
122102070  Igf2; insulin-like growth factor II [KO:K13769]
122102073  Ins; insulin [KO:K04526]
122102139  Gngt2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 [KO:K04549]
122102140  [KO:K10151]
122102319  Ccne2; G1/S-specific cyclin-E2 isoform X1 [KO:K06626]
122102398  Angpt1; angiopoietin-1 isoform X1 [KO:K05465]
122102408  Myc; myc proto-oncogene protein [KO:K04377]
122102479  Ywhaz; 14-3-3 protein zeta/delta [KO:K16197]
122102538  Vwf; LOW QUALITY PROTEIN: von Willebrand factor [KO:K03900]
122102605  Ntf3; neurotrophin-3 [KO:K04356]
122102620  Myb; transcriptional activator Myb isoform X1 [KO:K09420]
122102629  Gys2; glycogen [starch] synthase, liver [KO:K00693] [EC:2.4.1.11]
122102807  Fgf23; fibroblast growth factor 23 [KO:K22428]
122102809  Fgf6; LOW QUALITY PROTEIN: fibroblast growth factor 6 [KO:K04358]
122102886  Ppp2r3b; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta [KO:K11583]
122102946  [KO:K04465]
122103188  G6pc3; glucose-6-phosphatase 3 isoform X1 [KO:K01084] [EC:3.1.3.9]
122103204  Erbb2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
122103268  Itga3; integrin alpha-3 [KO:K06482]
122103287  [KO:K05438]
122103342  Chad; chondroadherin [KO:K06248]
122103362  G6pc1; glucose-6-phosphatase catalytic subunit 1 [KO:K01084] [EC:3.1.3.9]
122103391  Col1a1; collagen alpha-1(I) chain [KO:K06236]
122103395  Itgb3; integrin beta-3 [KO:K06493]
122103440  Brca1; breast cancer type 1 susceptibility protein isoform X1 [KO:K10605] [EC:2.3.2.27]
122103503  Ngfr; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
122103508  Csf3; granulocyte colony-stimulating factor isoform X1 [KO:K05423]
122103681  Tnn; tenascin-N [KO:K06252]
122103719  Lamc1; laminin subunit gamma-1 [KO:K05635]
122103778  Tnr; tenascin-R [KO:K06252]
122103807  Faslg; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
122103934  Lamc2; laminin subunit gamma-2 [KO:K06246]
122104212  Pdgfd; platelet-derived growth factor D isoform X1 [KO:K05450]
122104327  Gng12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
122104384  Lama3; laminin subunit alpha-3 isoform X1 [KO:K06240]
122104437  [KO:K04545]
122104495  Foxo3; forkhead box protein O3 [KO:K09408]
122104519  Sos1; son of sevenless homolog 1 isoform X1 [KO:K03099]
122104663  Ppp2r5b; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform [KO:K11584]
122104926  Vegfb; vascular endothelial growth factor B isoform X1 [KO:K16858]
122105011  Creb3l1; cyclic AMP-responsive element-binding protein 3-like protein 1 isoform X1 [KO:K09048]
122105036  Bad; bcl2-associated agonist of cell death isoform X1 [KO:K02158]
122105094  Rela; transcription factor p65 isoform X1 [KO:K04735]
122105120  Gng3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
122105224  Chrm1; muscarinic acetylcholine receptor M1 [KO:K04129]
122105362  Rps6kb2; ribosomal protein S6 kinase beta-2 isoform X1 [KO:K04688] [EC:2.7.11.1]
122105516  Col9a2; collagen alpha-2(IX) chain [KO:K08131]
122105860  Gng5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
122105913  Nos3; nitric oxide synthase, endothelial [KO:K13242] [EC:1.14.13.39]
122105949  Creb3l2; cyclic AMP-responsive element-binding protein 3-like protein 2 isoform X1 [KO:K09048]
122105955  Rheb; GTP-binding protein Rheb [KO:K07208]
122105971  Chrm2; muscarinic acetylcholine receptor M2 [KO:K04130]
122106294  [KO:K04382] [EC:3.1.3.16]
122106295  [KO:K04382] [EC:3.1.3.16]
122106299  Col2a1; collagen alpha-1(II) chain isoform X1 [KO:K19719]
122106484  Sos2; son of sevenless homolog 2 [KO:K03099]
122106523  Gng2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 [KO:K07826]
122106534  Ppp2r3c; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma [KO:K11583]
122106617  Lpar3; lysophosphatidic acid receptor 3 isoform X1 [KO:K04294]
122106648  Kdr; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
122106871  Pdgfra; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
122106872  Kit; mast/stem cell growth factor receptor Kit isoform X1 [KO:K05091] [EC:2.7.10.1]
122106885  Fgf5; fibroblast growth factor 5 [KO:K04358]
122106898  Areg; amphiregulin [KO:K09782]
122106918  Ereg; proepiregulin [KO:K09784]
122106999  Prl; prolactin isoform X1 [KO:K05439]
122107005  Sgk1; serine/threonine-protein kinase Sgk1 isoform X1 [KO:K13302] [EC:2.7.11.1]
122107098  Tlr4; toll-like receptor 4 isoform X1 [KO:K10160]
122107140  Tnc; tenascin isoform X1 [KO:K06252]
122107224  Col6a3; collagen alpha-3(VI) chain [KO:K06238]
122107232  Pik3ca; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
122107322  Creb1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
122107363  Col4a3; collagen alpha-3(IV) chain [KO:K06237]
122107423  Eif4e2; eukaryotic translation initiation factor 4E type 2 isoform X1 [KO:K03259]
122107464  Irs1; insulin receptor substrate 1 [KO:K16172]
122107486  Erbb4; receptor tyrosine-protein kinase erbB-4 [KO:K05085] [EC:2.7.10.1]
122107516  Fn1; fibronectin isoform X1 [KO:K05717]
122107567  Col4a4; collagen alpha-4(IV) chain [KO:K06237]
122107616  Fgfr1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
122107645  Eif4ebp1; eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
122107663  Ikbkb; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
122107826  Raf1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
122107928  [KO:K04465]
122107929  [KO:K04465]
122108039  Magi1; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X1 [KO:K05631]
122108047  [KO:K02649]
122108067  [KO:K04465]
122108068  [KO:K04465]
122108069  [KO:K04465]
122108071  [KO:K04465]
122108072  [KO:K04465]
122108520  Vegfd; vascular endothelial growth factor D [KO:K05449]
122108695  Il7; interleukin-7 isoform X1 [KO:K05431]
122108775  Ywhaq; 14-3-3 protein theta [KO:K16197]
122108868  Lamc3; laminin subunit gamma-3 [KO:K06247]
122108917  Pkn3; serine/threonine-protein kinase N3 isoform X1 [KO:K23692]
122108951  Tsc1; hamartin isoform X1 [KO:K07206]
122108988  Rxra; retinoic acid receptor RXR-alpha [KO:K08524]
122109053  Itga10; integrin alpha-10 isoform X1 [KO:K06586]
122109178  Csf1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453]
122109270  Thbs3; thrombospondin-3 [KO:K04659]
122109388  Il6r; interleukin-6 receptor subunit alpha [KO:K05055]
122109403  Efna1; ephrin-A1 [KO:K05462]
122109414  Ppp2r5a; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform [KO:K11584]
122109437  Them4; acyl-coenzyme A thioesterase THEM4 [KO:K16339] [EC:3.1.2.2]
122109468  Artn; artemin isoform X1 [KO:K25415]
122109474  Efna3; ephrin-A3 isoform X1 [KO:K05462]
122109523  Efna4; ephrin-A4 isoform X1 [KO:K05462]
122109534  Creb3l4; cyclic AMP-responsive element-binding protein 3-like protein 4 [KO:K09048]
122109555  Crtc2; CREB-regulated transcription coactivator 2 isoform X1 [KO:K16333]
122109580  Lamb3; laminin subunit beta-3 [KO:K06244]
122109658  Ntrk1; high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
122109719  Mcl1; induced myeloid leukemia cell differentiation protein Mcl-1 isoform X1 [KO:K02539]
122110009  Ppp2r5e; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform isoform X1 [KO:K11584]
122110283  Ppp2r1b; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform [KO:K03456]
122110678  [KO:K03456]
122110843  Itgb6; integrin beta-6 [KO:K06589]
122110980  Jak1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
122111108  Tnxb; tenascin-X isoform X1 [KO:K06252]
122111380  Cdkn1a; cyclin-dependent kinase inhibitor 1 [KO:K06625]
122111396  Atf6b; LOW QUALITY PROTEIN: cyclic AMP-dependent transcription factor ATF-6 beta [KO:K09049]
122111398  Csf3r; granulocyte colony-stimulating factor receptor isoform X1 [KO:K05061]
122111802  Magi2; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 [KO:K05629]
122111833  Col1a2; collagen alpha-2(I) chain isoform X1 [KO:K06236]
122111839  Cdk6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
122111854  Lamb1; laminin subunit beta-1 [KO:K05636]
122111861  Gng11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
122111901  Pik3cg; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform isoform X1 [KO:K21289] [EC:2.7.1.153]
122111933  Gngt1; guanine nucleotide-binding protein G(T) subunit gamma-T1 [KO:K04548]
122111940  Hgf; hepatocyte growth factor isoform X1 [KO:K05460]
122111951  Reln; reelin isoform X1 [KO:K06249] [EC:3.4.21.-]
122111961  Lamb4; laminin subunit beta-4 [KO:K06245]
122112101  [KO:K05405]
122112102  [KO:K05405]
122112193  Creb5; cyclic AMP-responsive element-binding protein 5 [KO:K09047]
122112209  Egfr; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
122112217  [KO:K05405]
122112548  Flt1; vascular endothelial growth factor receptor 1 isoform X1 [KO:K05096] [EC:2.7.10.1]
122112631  Flt3; receptor-type tyrosine-protein kinase FLT3 [KO:K05092] [EC:2.7.10.1]
122112816  Lpar6; lysophosphatidic acid receptor 6 [KO:K04273]
122112831  Fgf9; fibroblast growth factor 9 [KO:K04358]
122112991  Itgb1; integrin beta-1 [KO:K05719]
122113060  Gng4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
122113091  [KO:K04545]
122113136  Itga8; integrin alpha-8 [KO:K06584]
122113142  Il2ra; interleukin-2 receptor subunit alpha [KO:K05068]
122113486  Pck2; phosphoenolpyruvate carboxykinase [GTP], mitochondrial isoform X1 [KO:K01596] [EC:4.1.1.32]
122113510  Rac1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
122113593  Ywhag; 14-3-3 protein gamma [KO:K16198]
122113605  Syk; tyrosine-protein kinase SYK isoform X1 [KO:K05855] [EC:2.7.10.2]
122113621  Pdgfa; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
122113662  Epo; erythropoietin [KO:K05437]
122113749  Gnb2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
122114214  Ifnar1; interferon alpha/beta receptor 1 [KO:K05130]
122114215  [KO:K13302] [EC:2.7.11.1]
122114217  Ifnar2; interferon alpha/beta receptor 2 [KO:K05131]
122114333  Thbs1; thrombospondin-1 [KO:K16857]
122114391  Map2k1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
122114508  Gnb5; guanine nucleotide-binding protein subunit beta-5 [KO:K04539]
122114692  Fgf7; fibroblast growth factor 7 [KO:K04358]
122114964  Itga4; integrin alpha-4 [KO:K06483]
122114967  Itgav; integrin alpha-V [KO:K06487]
122115382  Ppp2ca; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
122115397  Il4; interleukin-4 [KO:K05430]
122115398  Il3; interleukin-3 [KO:K04736]
122115490  Flt4; vascular endothelial growth factor receptor 3 [KO:K05097] [EC:2.7.10.1]
122115548  [KO:K04542]
122115868  Pten; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
122115891  [KO:K04542]
122115917  Chuk; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
122115956  Fgf8; fibroblast growth factor 8 isoform X1 [KO:K04358]
122115969  Pik3ap1; phosphoinositide 3-kinase adapter protein 1 [KO:K12230]
122116275  Rbl2; retinoblastoma-like protein 2 isoform X1 [KO:K16332]
122116362  Col4a6; collagen alpha-6(IV) chain [KO:K06237]
122116370  Col4a5; collagen alpha-5(IV) chain isoform X1 [KO:K06237]
122116556  Ddit4; DNA damage-inducible transcript 4 protein [KO:K08270]
122116928  Prkaa1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform X1 [KO:K07198] [EC:2.7.11.31]
122116951  Itga2; integrin alpha-2 [KO:K06481]
122116962  Il7r; interleukin-7 receptor subunit alpha [KO:K05072]
122116965  Ghr; growth hormone receptor [KO:K05080]
122116967  Itga1; integrin alpha-1 isoform X1 [KO:K06480]
122116976  Prlr; prolactin receptor [KO:K05081]
122116981  Gdnf; glial cell line-derived neurotrophic factor [KO:K05452]
122116983  Osmr; oncostatin-M-specific receptor subunit beta isoform X1 [KO:K05057]
122117016  Fgf10; fibroblast growth factor 10 [KO:K04358]
122117203  Thbs4; thrombospondin-4 [KO:K04659]
122117244  F2r; proteinase-activated receptor 1 [KO:K03914]
122117335  Rps6kb1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
122117343  Pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
122117365  Vtn; vitronectin [KO:K06251]
122117755  Bdnf; brain-derived neurotrophic factor isoform X1 [KO:K04355]
122118146  Ppp2r2b; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform [KO:K04354]
122118168  Pdgfrb; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
122118224  Fgf1; fibroblast growth factor 1 [KO:K18496]
122118243  Csf1r; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
122118247  Efna5; ephrin-A5 isoform X1 [KO:K05462]
122118311  Pkn2; serine/threonine-protein kinase N2 [KO:K23691]
122118367  Nras; GTPase NRas [KO:K07828]
122118375  Ngf; beta-nerve growth factor [KO:K02582]
122118724  Pgf; placenta growth factor isoform X1 [KO:K16859]
122118851  Tcl1a; T-cell leukemia/lymphoma protein 1A [KO:K10167]
122118940  [KO:K05414]
122118944  [KO:K05414]
122118945  [KO:K05414]
122118947  Rps6; 40S ribosomal protein S6 [KO:K02991]
122118948  [KO:K05414]
122118949  [KO:K05414]
122118950  [KO:K05414]
122118956  [KO:K05414]
122118961  [KO:K05414]
122118962  Ifnb1; interferon beta [KO:K05415]
122118984  [KO:K05414]
122119078  Fgf2; fibroblast growth factor 2 [KO:K18497]
122119081  Il2; interleukin-2 [KO:K05429]
122119092  Hsp90b1; endoplasmin [KO:K09487]
122119152  Pik3r6; phosphoinositide 3-kinase regulatory subunit 6 [KO:K21290]
122119178  Kitlg; kit ligand isoform X1 [KO:K05461]
122119198  Igf1; insulin-like growth factor I isoform X1 [KO:K05459]
122119318  Il2rb; interleukin-2 receptor subunit beta isoform X1 [KO:K05069]
122119434  Bcl2; apoptosis regulator Bcl-2 isoform X1 [KO:K02161]
122119565  Insr; insulin receptor isoform X1 [KO:K04527] [EC:2.7.10.1]
122119735  Epor; erythropoietin receptor [KO:K05079]
122119789  Cdc37; hsp90 co-chaperone Cdc37 [KO:K09554]
122119801  Pkn1; serine/threonine-protein kinase N1 isoform X1 [KO:K06071] [EC:2.7.11.13]
122120051  Atf2; LOW QUALITY PROTEIN: cyclic AMP-dependent transcription factor ATF-2 [KO:K04450]
122120069  Itga6; integrin alpha-6 isoform X1 [KO:K06485]
122120138  G6pc2; glucose-6-phosphatase 2 isoform X1 [KO:K01084] [EC:3.1.3.9]
122120172  Sgk2; serine/threonine-protein kinase Sgk2 isoform X1 [KO:K13303] [EC:2.7.11.1]
122120195  Ywhab; 14-3-3 protein beta/alpha [KO:K16197]
122120267  Bcl2l1; bcl-2-like protein 1 isoform X1 [KO:K04570]
122120285  Pik3r5; phosphoinositide 3-kinase regulatory subunit 5 [KO:K21290]
122120328  Angpt4; LOW QUALITY PROTEIN: angiopoietin-4 [KO:K05467]
122120620  Il2rg; LOW QUALITY PROTEIN: cytokine receptor common subunit gamma [KO:K05070]
122121136  Col6a2; collagen alpha-2(VI) chain isoform X1 [KO:K06238]
122121144  Col6a1; collagen alpha-1(VI) chain [KO:K06238]
122121284  Bcl2l11; bcl-2-like protein 11 isoform X1 [KO:K16341]
122121294  Tek; angiopoietin-1 receptor isoform X1 [KO:K05121] [EC:2.7.10.1]
122121485  Lpar1; lysophosphatidic acid receptor 1 [KO:K04289]
122121501  Pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
122121508  Mtor; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
122121557  Itgb8; integrin beta-8 isoform X1 [KO:K06591]
122121653  Gng10; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
122121823  Met; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
122121860  Lama2; laminin subunit alpha-2 [KO:K05637]
122122111  Ntrk2; BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
122122245  Ret; proto-oncogene tyrosine-protein kinase receptor Ret [KO:K05126] [EC:2.7.10.1]
122122586  Ppp2r5c; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X1 [KO:K11584]
122122628  Hsp90aa1; heat shock protein HSP 90-alpha [KO:K04079]
122122732  Col4a1; collagen alpha-1(IV) chain [KO:K06237]
122122758  Col4a2; collagen alpha-2(IV) chain [KO:K06237]
122122760  Pspn; persephin [KO:K25416]
122122829  Efna2; ephrin-A2 [KO:K05462]
122122831  [KO:K04542]
122122838  Fgf22; fibroblast growth factor 22 [KO:K04358]
122122866  Nrtn; neurturin [KO:K25414]
122122873  Stk11; serine/threonine-protein kinase STK11 isoform X1 [KO:K07298] [EC:2.7.11.1]
122122893  Creb3; cyclic AMP-responsive element-binding protein 3 isoform X1 [KO:K09048]
122122943  Itga11; integrin alpha-11 [KO:K06587]
122123339  [KO:K00922] [EC:2.7.1.153]
122123494  Ppp2r2a; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform [KO:K04354]
122123581  Pdgfb; platelet-derived growth factor subunit B [KO:K17386]
122123666  Atf4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
122123834  Tsc2; tuberin isoform X1 [KO:K07207]
122123877  Mlst8; target of rapamycin complex subunit LST8 [KO:K08266]
122123899  Pdpk1; 3-phosphoinositide-dependent protein kinase 1 isoform X1 [KO:K06276] [EC:2.7.11.1]
122123999  Igf1r; insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
122124078  Mdm2; E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:2.3.2.27]
122124085  Cdk4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
122124201  Erbb3; receptor tyrosine-protein kinase erbB-3 [KO:K05084] [EC:2.7.10.1]
122124271  Itgb7; integrin beta-7 [KO:K06590]
122124341  Eif4b; eukaryotic translation initiation factor 4B isoform X1 [KO:K03258]
122124347  Itga5; integrin alpha-5 [KO:K06484]
122124349  Cdk2; cyclin-dependent kinase 2 isoform X1 [KO:K02206] [EC:2.7.11.22]
122124386  [KO:K06583]
122124478  Lama1; laminin subunit alpha-1 [KO:K05637]
122124495  [KO:K05126] [EC:2.7.10.1]
122124516  Prkaa2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 [KO:K07198] [EC:2.7.11.31]
122124571  Pck1; phosphoenolpyruvate carboxykinase, cytosolic [GTP] [KO:K01596] [EC:4.1.1.32]
122124653  Jak2; tyrosine-protein kinase JAK2 isoform X1 [KO:K04447] [EC:2.7.10.2]
122125001  Lama5; laminin subunit alpha-5 [KO:K06240]
122125004  Col9a3; collagen alpha-3(IX) chain [KO:K08131]
122125176  Tgfa; protransforming growth factor alpha [KO:K08774]
122125262  Angpt2; angiopoietin-2 isoform X1 [KO:K05466]
122125312  Ptk2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
122125515  [KO:K03456]
122125518  [KO:K03456]
122125535  [KO:K03456]
122125543  [KO:K03456]
122125547  [KO:K03456]
122125586  Fgf21; fibroblast growth factor 21 [KO:K22429]
122125712  Flt3lg; fms-related tyrosine kinase 3 ligand isoform X1 [KO:K05454]
122125865  Gys1; glycogen [starch] synthase, muscle [KO:K00693] [EC:2.4.1.11]
122125884  Ntf4; neurotrophin-4 [KO:K12457]
122125901  Gng8; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 [KO:K04544]
122126084  Vegfc; vascular endothelial growth factor C [KO:K05449]
122126106  Phlpp2; PH domain leucine-rich repeat-containing protein phosphatase 2 isoform X1 [KO:K16340] [EC:3.1.3.16]
122126696  Akt3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
122126852  Fgfr2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
122126971  Ppp2cb; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
122127051  Egf; pro-epidermal growth factor [KO:K04357]
122127124  Eif4e; eukaryotic translation initiation factor 4E [KO:K03259]
122127146  Tlr2; toll-like receptor 2 [KO:K10159]
122127164  Nfkb1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
122127332  Gnb1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
122127554  Fgf20; fibroblast growth factor 20 [KO:K04358]
122128350  Prkca; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
122128376  Grb2; growth factor receptor-bound protein 2 isoform X1 [KO:K04364]
Compound
C00020  AMP
C00533  Nitric oxide
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:16847462
  Authors
Engelman JA, Luo J, Cantley LC
  Title
The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism.
  Journal
Nat Rev Genet 7:606-19 (2006)
DOI:10.1038/nrg1879
Reference
PMID:15784165
  Authors
Song G, Ouyang G, Bao S
  Title
The activation of Akt/PKB signaling pathway and cell survival.
  Journal
J Cell Mol Med 9:59-71 (2005)
DOI:10.1111/j.1582-4934.2005.tb00337.x
Reference
PMID:21620960
  Authors
Hers I, Vincent EE, Tavare JM
  Title
Akt signalling in health and disease.
  Journal
Cell Signal 23:1515-27 (2011)
DOI:10.1016/j.cellsig.2011.05.004
Reference
PMID:18842113
  Authors
Duronio V
  Title
The life of a cell: apoptosis regulation by the PI3K/PKB pathway.
  Journal
Biochem J 415:333-44 (2008)
DOI:10.1042/BJ20081056
Reference
PMID:16248975
  Authors
Kim D, Chung J.
  Title
Akt: versatile mediator of cell survival and beyond.
  Journal
J Biochem Mol Biol 35:106-15 (2002)
DOI:10.5483/bmbrep.2002.35.1.106
Reference
PMID:12660731
  Authors
Koyasu S
  Title
The role of PI3K in immune cells.
  Journal
Nat Immunol 4:313-9 (2003)
DOI:10.1038/ni0403-313
Reference
PMID:12669022
  Authors
Okkenhaug K, Vanhaesebroeck B.
  Title
PI3K in lymphocyte development, differentiation and activation.
  Journal
Nat Rev Immunol 3:317-30 (2003)
DOI:10.1038/nri1056
Reference
PMID:15209374
  Authors
Richardson CJ, Schalm SS, Blenis J
  Title
PI3-kinase and TOR: PIKTORing cell growth.
  Journal
Semin Cell Dev Biol 15:147-59 (2004)
DOI:10.1016/j.semcdb.2003.12.023
Reference
PMID:21440011
  Authors
Zhang X, Tang N, Hadden TJ, Rishi AK
  Title
Akt, FoxO and regulation of apoptosis.
  Journal
Biochim Biophys Acta 1813:1978-86 (2011)
DOI:10.1016/j.bbamcr.2011.03.010
Reference
PMID:21779440
  Authors
Georgescu MM
  Title
PTEN Tumor Suppressor Network in PI3K-Akt Pathway Control.
  Journal
Genes Cancer 1:1170-7 (2010)
DOI:10.1177/1947601911407325
Reference
PMID:12531180
  Authors
West KA, Castillo SS, Dennis PA
  Title
Activation of the PI3K/Akt pathway and chemotherapeutic resistance.
  Journal
Drug Resist Updat 5:234-48 (2002)
DOI:10.1016/S1368-7646(02)00120-6
Reference
PMID:9838078
  Authors
Wymann MP, Pirola L
  Title
Structure and function of phosphoinositide 3-kinases.
  Journal
Biochim Biophys Acta 1436:127-50 (1998)
DOI:10.1016/S0005-2760(98)00139-8
Reference
PMID:12048182
  Authors
Moelling K, Schad K, Bosse M, Zimmermann S, Schweneker M
  Title
Regulation of Raf-Akt Cross-talk.
  Journal
J Biol Chem 277:31099-106 (2002)
DOI:10.1074/jbc.M111974200
Reference
PMID:16187290
  Authors
Kikani CK, Dong LQ, Liu F
  Title
"New"-clear functions of PDK1: beyond a master kinase in the cytosol?
  Journal
J Cell Biochem 96:1157-62 (2005)
DOI:10.1002/jcb.20651
Reference
PMID:11357143
  Authors
Blume-Jensen P, Hunter T
  Title
Oncogenic kinase signalling.
  Journal
Nature 411:355-65 (2001)
DOI:10.1038/35077225
Reference
PMID:15505410
  Authors
Osaki M, Oshimura M, Ito H
  Title
PI3K-Akt pathway: its functions and alterations in human cancer.
  Journal
Apoptosis 9:667-76 (2004)
DOI:10.1023/B:APPT.0000045801.15585.dd
Reference
PMID:17360849
  Authors
Noguchi M, Ropars V, Roumestand C, Suizu F
  Title
Proto-oncogene TCL1: more than just a coactivator for Akt.
  Journal
FASEB J 21:2273-84 (2007)
DOI:10.1096/fj.06-7684com
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Related
pathway
dsp00010  Glycolysis / Gluconeogenesis
dsp04010  MAPK signaling pathway
dsp04012  ErbB signaling pathway
dsp04062  Chemokine signaling pathway
dsp04064  NF-kappa B signaling pathway
dsp04068  FoxO signaling pathway
dsp04110  Cell cycle
dsp04115  p53 signaling pathway
dsp04150  mTOR signaling pathway
dsp04210  Apoptosis
dsp04370  VEGF signaling pathway
dsp04510  Focal adhesion
dsp04620  Toll-like receptor signaling pathway
dsp04630  JAK-STAT signaling pathway
dsp04662  B cell receptor signaling pathway
dsp04910  Insulin signaling pathway
KO pathway
ko04151   

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