KEGG   PATHWAY: epz05167
Entry
epz05167                    Pathway                                
Name
Kaposi sarcoma-associated herpesvirus infection - Equus przewalskii (Przewalski's horse)
Description
Kaposi sarcoma-associated herpesvirus (KSHV), also known as human herpesvirus 8 (HHV-8), is the most recently identified human tumor virus, and is associated with the pathogenesis of Kaposi's sarcoma (KS), primary effusion lymphoma (PEL), and Multicentric Castleman's disease (MCD). Like all other herpesviruses, KSHV displays two modes of life cycle, latency and lytic replication, which are characterized by the patterns of viral gene expression. Genes expressed in latency (LANA, v-cyclin, v-FLIP, Kaposins A, B and C and viral miRNAs) are mainly thought to facilitate the establishment of life long latency in its host and survival against the host innate, and adaptive immune surveillance mechanisms. Among the viral proteins shown to be expressed during lytic replication are potent signaling molecules such as vGPCR, vIL6, vIRFs, vCCLs, K1 and K15, which have been implicated experimentally in the angiogenic and inflammatory phenotype observed in KS lesions. Several of these latent viral and lytic proteins are known to transform host cells, linking KSHV with the development of severe human malignancies.
Class
Human Diseases; Infectious disease: viral
Pathway map
epz05167  Kaposi sarcoma-associated herpesvirus infection
epz05167

Organism
Equus przewalskii (Przewalski's horse) [GN:epz]
Gene
103540378  C3; complement C3 [KO:K03990]
103558001  TLR3; toll like receptor 3 [KO:K05401]
103545173  TICAM1; toll like receptor adaptor molecule 1 [KO:K05842]
103563515  TRAF3; TNF receptor associated factor 3 [KO:K03174]
103553835  IKBKE; inhibitor of nuclear factor kappa B kinase subunit epsilon [KO:K07211] [EC:2.7.11.10]
103557811  TBK1; TANK binding kinase 1 [KO:K05410] [EC:2.7.11.10]
103567336  IRF7; interferon regulatory factor 7 [KO:K09447]
103558747  interferon alpha-2-like [KO:K05414]
103558748  interferon alpha-3 [KO:K05414]
103558749  interferon alpha-6-like [KO:K05414]
103558750  interferon alpha-2 [KO:K05414]
103544584  interferon alpha-14-like [KO:K05414]
103563152  interferon alpha-2-like [KO:K05414]
103563154  interferon alpha-2-like [KO:K05414]
103567855  interferon alpha-1-like [KO:K05414]
103541756  IRF3; interferon regulatory factor 3 [KO:K05411]
103553025  CREBBP; CREB binding protein [KO:K04498] [EC:2.3.1.48]
103556116  EP300; E1A binding protein p300 [KO:K04498] [EC:2.3.1.48]
103563147  interferon beta-like [KO:K05415]
103563148  interferon beta [KO:K05415]
103563150  interferon beta-like [KO:K05415]
103549120  IFNAR1; interferon alpha and beta receptor subunit 1 [KO:K05130]
103549136  IFNAR2; interferon alpha and beta receptor subunit 2 [KO:K05131]
103560394  JAK1; Janus kinase 1 [KO:K11217] [EC:2.7.10.2]
103541709  non-receptor tyrosine-protein kinase TYK2-like [KO:K11219] [EC:2.7.10.2]
103548655  STAT1; signal transducer and activator of transcription 1 [KO:K11220]
103557548  STAT2; signal transducer and activator of transcription 2 [KO:K11221]
103564029  IRF9; interferon regulatory factor 9 [KO:K04693]
103548399  EIF2AK2; eukaryotic translation initiation factor 2 alpha kinase 2 [KO:K16195] [EC:2.7.11.1]
103565534  MAPK14; mitogen-activated protein kinase 14 [KO:K04441] [EC:2.7.11.24]
103563198  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
103559485  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
103559491  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
103567219  MAPKAPK2; mitogen-activated protein kinase-activated protein kinase 2 [KO:K04443] [EC:2.7.11.1]
103564566  MAP2K6; mitogen-activated protein kinase kinase 6 [KO:K04433] [EC:2.7.12.2]
103561141  IL6; interleukin 6 [KO:K05405]
103556575  CSF2; colony stimulating factor 2 [KO:K05427]
103555073  CCR3; C-C motif chemokine receptor 3 [KO:K04178]
103567211  C-C chemokine receptor type 5 [KO:K04180]
103555072  CCR1; C-C motif chemokine receptor 1 [KO:K04176]
103561101  CCR4; C-C motif chemokine receptor 4 [KO:K04179]
103547099  CCR8; C-C motif chemokine receptor 8 [KO:K04183]
103558124  FAS; Fas cell surface death receptor [KO:K04390]
103566999  FADD; Fas associated via death domain [KO:K02373]
103565685  CASP8; caspase 8 [KO:K04398] [EC:3.4.22.61]
103559205  BID; BH3 interacting domain death agonist [KO:K04726]
103553312  BAX; BCL2 associated X, apoptosis regulator [KO:K02159]
103544222  BAK1; BCL2 antagonist/killer 1 [KO:K14021]
103547975  cytochrome c, testis-specific [KO:K08738]
103561978  cytochrome c [KO:K08738]
103565016  CASP9; caspase 9 [KO:K04399] [EC:3.4.22.62]
103549132  CASP3; caspase 3 [KO:K02187] [EC:3.4.22.56]
103546993  TNFRSF1A; TNF receptor superfamily member 1A [KO:K03158]
103542683  TRADD; TNFRSF1A associated via death domain [KO:K03171]
103567822  TRAF2; TNF receptor associated factor 2 [KO:K03173] [EC:2.3.2.27]
103567228  CHUK; conserved helix-loop-helix ubiquitous kinase [KO:K04467] [EC:2.7.11.10]
103562903  IKBKB; inhibitor of nuclear factor kappa B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
103543979  NF-kappa-B essential modulator-like [KO:K07210]
103546400  NFKBIA; NFKB inhibitor alpha [KO:K04734]
103556719  NFKB1; nuclear factor kappa B subunit 1 [KO:K02580]
103543692  RELA; RELA proto-oncogene, NF-kB subunit [KO:K04735]
103557703  TP53; tumor protein p53 [KO:K04451]
103564535  CDKN1A; cyclin dependent kinase inhibitor 1A [KO:K06625]
103553644  CDK4; cyclin dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
103549196  CDK6; cyclin dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
103549440  RB1; RB transcriptional corepressor 1 [KO:K06618]
103541516  E2F1; E2F transcription factor 1 [KO:K17454]
103551301  E2F2; E2F transcription factor 2 [KO:K09389]
103549781  E2F3; E2F transcription factor 3 [KO:K06620]
103544108  saoe class I histocompatibility antigen, A alpha chain-like [KO:K06751]
103544263  HLA class I histocompatibility antigen, A-11 alpha chain-like [KO:K06751]
103544779  class I histocompatibility antigen, Gogo-OKO alpha chain-like [KO:K06751]
103544915  patr class I histocompatibility antigen, A-2 alpha chain-like [KO:K06751]
103544893  HLA class I histocompatibility antigen, B-14 alpha chain-like [KO:K06751]
103543990  patr class I histocompatibility antigen, B-1 alpha chain-like [KO:K06751]
103544101  class I histocompatibility antigen, Gogo-B*0103 alpha chain-like [KO:K06751]
103544987  HLA class I histocompatibility antigen, alpha chain G-like [KO:K06751]
103545903  DLA class I histocompatibility antigen, A9/A9 alpha chain-like [KO:K06751]
103545933  HLA class I histocompatibility antigen, Cw-12 alpha chain-like [KO:K06751]
103567269  HLA class I histocompatibility antigen, B-14 alpha chain-like [KO:K06751]
103542270  HLA class I histocompatibility antigen, A-69 alpha chain-like [KO:K06751]
103542271  popy class I histocompatibility antigen, alpha chain E-like [KO:K06751]
103545683  DLA class I histocompatibility antigen, A9/A9 alpha chain-like [KO:K06751]
103545236  saoe class I histocompatibility antigen, A alpha chain-like [KO:K06751]
103545593  saoe class I histocompatibility antigen, A alpha chain-like [KO:K06751]
103549045  IFNGR1; interferon gamma receptor 1 [KO:K05132]
103558066  ICAM1; intercellular adhesion molecule 1 [KO:K06490]
103548423  CD86; CD86 molecule [KO:K05413]
103544088  MHC class I polypeptide-related sequence B-like [KO:K07985]
103541161  MHC class I polypeptide-related sequence B-like [KO:K07985]
103545592  MHC class I polypeptide-related sequence B-like [KO:K07985]
103540422  CLEC2B; C-type lectin domain family 2 member B [KO:K10071]
103567549  UBA52; ubiquitin A-52 residue ribosomal protein fusion product 1 [KO:K02927]
103555326  E3 ubiquitin-protein ligase parkin-like [KO:K02977]
103546262  RPS27A; ribosomal protein S27a [KO:K02977]
103545744  polyubiquitin-B [KO:K04551]
103544117  beclin-2-like [KO:K08334]
103550344  BECN1; beclin 1 [KO:K08334]
103561925  ATG14; autophagy related 14 [KO:K17889]
103543294  phosphatidylinositol 3-kinase catalytic subunit type 3-like [KO:K00914] [EC:2.7.1.137]
103557587  ATG3; autophagy related 3 [KO:K08343]
103541919  MAP1LC3B; microtubule associated protein 1 light chain 3 beta [KO:K10435]
103553791  MAP1LC3A; microtubule associated protein 1 light chain 3 alpha [KO:K10435]
103555813  microtubule-associated proteins 1A/1B light chain 3 beta 2-like [KO:K10435]
103559026  MAP1LC3C; microtubule associated protein 1 light chain 3 gamma [KO:K10435]
103564069  microtubule-associated proteins 1A/1B light chain 3B-like [KO:K10435]
103564607  microtubule-associated proteins 1A/1B light chain 3 beta 2-like [KO:K10435]
103562395  microtubule-associated proteins 1A/1B light chain 3B [KO:K10435]
103567413  GNB1; G protein subunit beta 1 [KO:K04536]
103555641  GNB2; G protein subunit beta 2 [KO:K04537]
103547020  GNB3; G protein subunit beta 3 [KO:K07825]
103551737  GNB4; G protein subunit beta 4 [KO:K04538]
103548465  GNB5; G protein subunit beta 5 [KO:K04539]
103543306  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 [KO:K07826]
103558941  GNG3; G protein subunit gamma 3 [KO:K04540]
103547680  GNG4; G protein subunit gamma 4 [KO:K04541]
103557283  GNG5; G protein subunit gamma 5 [KO:K04542]
103542500  GNG8; G protein subunit gamma 8 [KO:K04544]
103542169  GNG11; G protein subunit gamma 11 [KO:K04546]
103564847  GNG12; G protein subunit gamma 12 [KO:K04347]
103542772  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04347]
103565302  GNG13; G protein subunit gamma 13 [KO:K04547]
103568001  GNGT1; G protein subunit gamma transducin 1 [KO:K04548]
103551067  GNGT2; G protein subunit gamma transducin 2 [KO:K04549]
103567332  HRAS; HRas proto-oncogene, GTPase [KO:K02833]
103546629  KRAS; KRAS proto-oncogene, GTPase [KO:K07827]
103552675  NRAS; neuroblastoma RAS viral oncogene homolog [KO:K07828]
103554541  RAF1; Raf-1 proto-oncogene, serine/threonine kinase [KO:K04366] [EC:2.7.11.1]
103549630  MAP2K1; mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
103543290  dual specificity mitogen-activated protein kinase kinase 2-like [KO:K04369] [EC:2.7.12.2]
103547261  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
103562408  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
103562790  HIF1A; hypoxia inducible factor 1 alpha subunit [KO:K08268]
103548618  FOS; Fos proto-oncogene, AP-1 transcription factor subunit [KO:K04379]
103557800  PIK3CG; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma [KO:K21289] [EC:2.7.1.153]
103564501  PIK3R5; phosphoinositide-3-kinase regulatory subunit 5 [KO:K21290]
103564503  PIK3R6; phosphoinositide-3-kinase regulatory subunit 6 [KO:K21290]
103549076  PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta [KO:K00922] [EC:2.7.1.153]
103554655  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform-like [KO:K00922] [EC:2.7.1.153]
103552150  PIK3CA; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha [KO:K00922] [EC:2.7.1.153]
103548220  PIK3R1; phosphoinositide-3-kinase regulatory subunit 1 [KO:K02649]
103551868  PIK3R3; phosphoinositide-3-kinase regulatory subunit 3 [KO:K02649]
103561550  PIK3R2; phosphoinositide-3-kinase regulatory subunit 2 [KO:K02649]
103560497  AKT2; AKT serine/threonine kinase 2 [KO:K04456] [EC:2.7.11.1]
103540249  AKT1; AKT serine/threonine kinase 1 [KO:K04456] [EC:2.7.11.1]
103555421  AKT3; AKT serine/threonine kinase 3 [KO:K04456] [EC:2.7.11.1]
103552237  MTOR; mechanistic target of rapamycin [KO:K07203] [EC:2.7.11.1]
103544089  PREX1; phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1 [KO:K12365]
103552260  ras-related C3 botulinum toxin substrate 1-like [KO:K04392]
103549414  MAPK8; mitogen-activated protein kinase 8 [KO:K04440] [EC:2.7.11.24]
103553980  MAPK10; mitogen-activated protein kinase 10 [KO:K04440] [EC:2.7.11.24]
103567629  MAPK9; mitogen-activated protein kinase 9 [KO:K04440] [EC:2.7.11.24]
103560842  CD200R1; CD200 receptor 1 [KO:K21668]
103560843  CD200R1L; CD200 receptor 1 like [KO:K21668]
103565660  SYK; spleen associated tyrosine kinase [KO:K05855] [EC:2.7.10.2]
103560907  SRC; SRC proto-oncogene, non-receptor tyrosine kinase [KO:K05704] [EC:2.7.10.2]
103554273  HCK; HCK proto-oncogene, Src family tyrosine kinase [KO:K08893] [EC:2.7.10.2]
103552502  LYN; LYN proto-oncogene, Src family tyrosine kinase [KO:K05854] [EC:2.7.10.2]
103567795  dual specificity mitogen-activated protein kinase kinase 4-like [KO:K04430] [EC:2.7.12.2]
103543808  MAP2K7; mitogen-activated protein kinase kinase 7 [KO:K04431] [EC:2.7.12.2]
103558212  PLCG2; phospholipase C gamma 2 [KO:K05859] [EC:3.1.4.11]
103562208  PLCG1; phospholipase C gamma 1 [KO:K01116] [EC:3.1.4.11]
103550297  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 [KO:K04958]
103546630  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
103548182  inositol 1,4,5-trisphosphate receptor type 2-like [KO:K04959]
103564724  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
103548885  CALML5; calmodulin like 5 [KO:K02183]
103548886  CALML3; calmodulin like 3 [KO:K02183]
103549905  CALM1; calmodulin 1 [KO:K02183]
103558105  CALM2; calmodulin 2 [KO:K02183]
103564053  calmodulin-like protein 4 [KO:K02183]
103544963  calmodulin-alpha-like [KO:K02183]
103567415  CALML6; calmodulin like 6 [KO:K02183]
103549452  PPP3CB; protein phosphatase 3 catalytic subunit beta [KO:K04348] [EC:3.1.3.16]
103552390  PPP3CA; protein phosphatase 3 catalytic subunit alpha [KO:K04348] [EC:3.1.3.16]
103552773  PPP3CC; protein phosphatase 3 catalytic subunit gamma [KO:K04348] [EC:3.1.3.16]
103548960  PPP3R1; protein phosphatase 3 regulatory subunit B, alpha [KO:K06268]
103552460  PPP3R2; protein phosphatase 3 regulatory subunit B, beta [KO:K06268]
103563745  nuclear factor of activated T-cells, cytoplasmic 1-like [KO:K04446]
103554877  NFATC2; nuclear factor of activated T-cells 2 [KO:K17332]
103549708  NFATC3; nuclear factor of activated T-cells 3 [KO:K17333]
103561060  NFATC4; nuclear factor of activated T-cells 4 [KO:K17334]
103566768  CXCL8; C-X-C motif chemokine ligand 8 [KO:K10030]
103547078  PTGS2; prostaglandin-endoperoxide synthase 2 [KO:K11987] [EC:1.14.99.1]
103565789  growth-regulated alpha protein-like [KO:K05505]
103565792  uncharacterized LOC103565792 [KO:K05505]
103548901  RCAN1; regulator of calcineurin 1 [KO:K17901]
103548136  VEGFA; vascular endothelial growth factor A [KO:K05448]
103565679  PDGFB; platelet derived growth factor subunit B [KO:K17386]
103547367  ANGPT2; angiopoietin 2 [KO:K05466]
103548204  IL6ST; interleukin 6 signal transducer [KO:K05060]
103554269  JAK2; Janus kinase 2 [KO:K04447] [EC:2.7.10.2]
103550364  STAT3; signal transducer and activator of transcription 3 [KO:K04692]
103547424  GSK3B; glycogen synthase kinase 3 beta [KO:K03083] [EC:2.7.11.26]
103552888  CTNNB1; catenin beta 1 [KO:K02105]
103543120  TCF7; transcription factor 7 (T-cell specific, HMG-box) [KO:K02620]
103548276  TCF7L1; transcription factor 7 like 1 [KO:K04490]
103564289  TCF7L2; transcription factor 7 like 2 [KO:K04491]
103557035  LEF1; lymphoid enhancer binding factor 1 [KO:K04492]
103548908  CREB1; cAMP responsive element binding protein 1 [KO:K05870]
103567860  MYC; v-myc avian myelocytomatosis viral oncogene homolog [KO:K04377]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00350  Phosphatidylethanolamine
C01245  D-myo-Inositol 1,4,5-trisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:22403573
  Authors
Lee HR, Brulois K, Wong L, Jung JU
  Title
Modulation of Immune System by Kaposi's Sarcoma-Associated Herpesvirus: Lessons from Viral Evasion Strategies.
  Journal
Front Microbiol 3:44 (2012)
DOI:10.3389/fmicb.2012.00044
Reference
PMID:18948197
  Authors
Liang C, Lee JS, Jung JU
  Title
Immune evasion in Kaposi's sarcoma-associated herpes virus associated oncogenesis.
  Journal
Semin Cancer Biol 18:423-36 (2008)
DOI:10.1016/j.semcancer.2008.09.003
Reference
PMID:21040832
  Authors
Cai Q, Verma SC, Lu J, Robertson ES
  Title
Molecular biology of Kaposi's sarcoma-associated herpesvirus and related oncogenesis.
  Journal
Adv Virus Res 78:87-142 (2010)
DOI:10.1016/B978-0-12-385032-4.00003-3
Reference
PMID:16760382
  Authors
Rezaee SA, Cunningham C, Davison AJ, Blackbourn DJ
  Title
Kaposi's sarcoma-associated herpesvirus immune modulation: an overview.
  Journal
J Gen Virol 87:1781-804 (2006)
DOI:10.1099/vir.0.81919-0
Reference
PMID:19230674
  Authors
Areste C, Blackbourn DJ
  Title
Modulation of the immune system by Kaposi's sarcoma-associated herpesvirus.
  Journal
Trends Microbiol 17:119-29 (2009)
DOI:10.1016/j.tim.2008.12.001
Reference
PMID:16905191
  Authors
Mark L, Spiller OB, Villoutreix BO, Blom AM
  Title
Kaposi's sarcoma-associated herpes virus complement control protein: KCP--complement inhibition and more.
  Journal
Mol Immunol 44:11-22 (2007)
DOI:10.1016/j.molimm.2006.06.018
Reference
PMID:11500830
  Authors
Weber KS, Grone HJ, Rocken M, Klier C, Gu S, Wank R, Proudfoot AE, Nelson PJ, Weber C
  Title
Selective recruitment of Th2-type cells and evasion from a cytotoxic immune response mediated by viral macrophage inhibitory protein-II.
  Journal
Eur J Immunol 31:2458-66 (2001)
DOI:10.1002/1521-4141(200108)31:8<2458::AID-IMMU2458>3.0.CO;2-L
Reference
PMID:10666184
  Authors
Stine JT, Wood C, Hill M, Epp A, Raport CJ, Schweickart VL, Endo Y, Sasaki T, Simmons G, Boshoff C, Clapham P, Chang Y, Moore P, Gray PW, Chantry D
  Title
KSHV-encoded CC chemokine vMIP-III is a CCR4 agonist, stimulates angiogenesis, and selectively chemoattracts TH2 cells.
  Journal
Blood 95:1151-7 (2000)
Reference
PMID:26431609
  Authors
Schulz TF, Cesarman E
  Title
Kaposi Sarcoma-associated Herpesvirus: mechanisms of oncogenesis.
  Journal
Curr Opin Virol 14:116-28 (2015)
DOI:10.1016/j.coviro.2015.08.016
Reference
PMID:10377196
  Authors
Endres MJ, Garlisi CG, Xiao H, Shan L, Hedrick JA
  Title
The Kaposi's sarcoma-related herpesvirus (KSHV)-encoded chemokine vMIP-I is a specific agonist for the CC chemokine receptor (CCR)8.
  Journal
J Exp Med 189:1993-8 (1999)
DOI:10.1084/jem.189.12.1993
Reference
PMID:18434408
  Authors
Choi YB, Nicholas J
  Title
Autocrine and paracrine promotion of cell survival and virus replication by human herpesvirus 8 chemokines.
  Journal
J Virol 82:6501-13 (2008)
DOI:10.1128/JVI.02396-07
Reference
PMID:15692053
  Authors
McCormick C, Ganem D
  Title
The kaposin B protein of KSHV activates the p38/MK2 pathway and stabilizes cytokine mRNAs.
  Journal
Science 307:739-41 (2005)
DOI:10.1126/science.1105779
Reference
PMID:15967719
  Authors
Wang HW, Boshoff C
  Title
Linking Kaposi virus to cancer-associated cytokines.
  Journal
Trends Mol Med 11:309-12 (2005)
DOI:10.1016/j.molmed.2005.06.002
Reference
PMID:16828973
  Authors
Jarviluoma A, Ojala PM
  Title
Cell signaling pathways engaged by KSHV.
  Journal
Biochim Biophys Acta 1766:140-58 (2006)
DOI:10.1016/j.bbcan.2006.05.001
Reference
PMID:12032073
  Authors
Wang HW, Sharp TV, Koumi A, Koentges G, Boshoff C
  Title
Characterization of an anti-apoptotic glycoprotein encoded by Kaposi's sarcoma-associated herpesvirus which resembles a spliced variant of human survivin.
  Journal
EMBO J 21:2602-15 (2002)
DOI:10.1093/emboj/21.11.2602
Reference
PMID:10510092
  Authors
Djerbi M, Screpanti V, Catrina AI, Bogen B, Biberfeld P, Grandien A
  Title
The inhibitor of death receptor signaling, FLICE-inhibitory protein defines a new class of tumor progression factors.
  Journal
J Exp Med 190:1025-32 (1999)
DOI:10.1084/jem.190.7.1025
Reference
PMID:10523854
  Authors
Chaudhary PM, Jasmin A, Eby MT, Hood L
  Title
Modulation of the NF-kappa B pathway by virally encoded death effector domains-containing proteins.
  Journal
Oncogene 18:5738-46 (1999)
DOI:10.1038/sj.onc.1202976
Reference
PMID:12890756
  Authors
Field N, Low W, Daniels M, Howell S, Daviet L, Boshoff C, Collins M
  Title
KSHV vFLIP binds to IKK-gamma to activate IKK.
  Journal
J Cell Sci 116:3721-8 (2003)
DOI:10.1242/jcs.00691
Reference
PMID:20865011
  Authors
Mesri EA, Cesarman E, Boshoff C
  Title
Kaposi's sarcoma and its associated herpesvirus.
  Journal
Nat Rev Cancer 10:707-19 (2010)
DOI:10.1038/nrc2888
Reference
PMID:10799607
  Authors
Ishido S, Wang C, Lee BS, Cohen GB, Jung JU
  Title
Downregulation of major histocompatibility complex class I molecules by Kaposi's sarcoma-associated herpesvirus K3 and K5 proteins.
  Journal
J Virol 74:5300-9 (2000)
DOI:10.1128/JVI.74.11.5300-5309.2000
Reference
PMID:17166914
  Authors
Li Q, Means R, Lang S, Jung JU
  Title
Downregulation of gamma interferon receptor 1 by Kaposi's sarcoma-associated herpesvirus K3 and K5.
  Journal
J Virol 81:2117-27 (2007)
DOI:10.1128/JVI.01961-06
Reference
PMID:18230726
  Authors
Thomas M, Boname JM, Field S, Nejentsev S, Salio M, Cerundolo V, Wills M, Lehner PJ
  Title
Down-regulation of NKG2D and NKp80 ligands by Kaposi's sarcoma-associated herpesvirus K5 protects against NK cell cytotoxicity.
  Journal
Proc Natl Acad Sci U S A 105:1656-61 (2008)
DOI:10.1073/pnas.0707883105
Reference
PMID:11413168
  Authors
Coscoy L, Ganem D
  Title
A viral protein that selectively downregulates ICAM-1 and B7-2 and modulates T cell costimulation.
  Journal
J Clin Invest 107:1599-606 (2001)
DOI:10.1172/JCI12432
Reference
PMID:24710493
  Authors
Pratt ZL, Sugden B
  Title
How human tumor viruses make use of autophagy.
  Journal
Cells 1:617-30 (2012)
DOI:10.3390/cells1030617
Reference
PMID:10354594
  Authors
Schulz TF, Moore PS
  Title
Kaposi's sarcoma-associated herpesvirus: a new human tumor virus, but how?
  Journal
Trends Microbiol 7:196-200 (1999)
DOI:10.1016/S0966-842X(99)01495-X
Reference
PMID:9594662
  Authors
Moore PS, Chang Y
  Title
Antiviral activity of tumor-suppressor pathways: clues from molecular piracy by KSHV.
  Journal
Trends Genet 14:144-50 (1998)
DOI:10.1016/S0168-9525(98)01408-5
Reference
PMID:12770701
  Authors
Verma SC, Robertson ES
  Title
Molecular biology and pathogenesis of Kaposi sarcoma-associated herpesvirus.
  Journal
FEMS Microbiol Lett 222:155-63 (2003)
DOI:10.1016/S0378-1097(03)00261-1
Reference
PMID:11960692
  Authors
Jenner RG, Boshoff C
  Title
The molecular pathology of Kaposi's sarcoma-associated herpesvirus.
  Journal
Biochim Biophys Acta 1602:1-22 (2002)
DOI:10.1016/S0304-419X(01)00040-3
Reference
PMID:15220441
  Authors
Foster-Cuevas M, Wright GJ, Puklavec MJ, Brown MH, Barclay AN
  Title
Human herpesvirus 8 K14 protein mimics CD200 in down-regulating macrophage activation through CD200 receptor.
  Journal
J Virol 78:7667-76 (2004)
DOI:10.1128/JVI.78.14.7667-7676.2004
Reference
PMID:10987301
  Authors
Sodhi A, Montaner S, Patel V, Zohar M, Bais C, Mesri EA, Gutkind JS
  Title
The Kaposi's sarcoma-associated herpes virus G protein-coupled receptor up-regulates vascular endothelial growth factor expression and secretion through mitogen-activated protein kinase and p38 pathways acting on hypoxia-inducible factor 1alpha.
  Journal
Cancer Res 60:4873-80 (2000)
Reference
PMID:27518127
  Authors
Abere B, Schulz TF
  Title
KSHV non-structural membrane proteins involved in the activation of intracellular signaling pathways and the pathogenesis of Kaposi's sarcoma.
  Journal
Curr Opin Virol 20:11-19 (2016)
DOI:10.1016/j.coviro.2016.07.008
Reference
PMID:15573137
  Authors
Sodhi A, Montaner S, Gutkind JS
  Title
Viral hijacking of G-protein-coupled-receptor signalling networks.
  Journal
Nat Rev Mol Cell Biol 5:998-1012 (2004)
DOI:10.1038/nrm1529
Reference
PMID:17329974
  Authors
Montaner S
  Title
Akt/TSC/mTOR activation by the KSHV G protein-coupled receptor: emerging insights into the molecular oncogenesis and treatment of Kaposi's sarcoma.
  Journal
Cell Cycle 6:438-43 (2007)
DOI:10.4161/cc.6.4.3843
Reference
PMID:23028325
  Authors
Bala K, Bosco R, Gramolelli S, Haas DA, Kati S, Pietrek M, Havemeier A, Yakushko Y, Singh VV, Dittrich-Breiholz O, Kracht M, Schulz TF
  Title
Kaposi's sarcoma herpesvirus K15 protein contributes to virus-induced angiogenesis by recruiting PLCgamma1 and activating NFAT1-dependent RCAN1 expression.
  Journal
PLoS Pathog 8:e1002927 (2012)
DOI:10.1371/journal.ppat.1002927
Reference
PMID:10318948
  Authors
Lagunoff M, Majeti R, Weiss A, Ganem D
  Title
Deregulated signal transduction by the K1 gene product of Kaposi's sarcoma-associated herpesvirus.
  Journal
Proc Natl Acad Sci U S A 96:5704-9 (1999)
DOI:10.1073/pnas.96.10.5704
Reference
PMID:26192396
  Authors
Sousa-Squiavinato AC, Silvestre RN, Elgui De Oliveira D
  Title
Biology and oncogenicity of the Kaposi sarcoma herpesvirus K1 protein.
  Journal
Rev Med Virol 25:273-85 (2015)
DOI:10.1002/rmv.1843
Reference
PMID:25187543
  Authors
Havemeier A, Gramolelli S, Pietrek M, Jochmann R, Sturzl M, Schulz TF
  Title
Activation of NF-kappaB by the Kaposi's sarcoma-associated herpesvirus K15 protein involves recruitment of the NF-kappaB-inducing kinase, IkappaB kinases, and phosphorylation of p65.
  Journal
J Virol 88:13161-72 (2014)
DOI:10.1128/JVI.01766-14
Reference
PMID:17050609
  Authors
Brinkmann MM, Pietrek M, Dittrich-Breiholz O, Kracht M, Schulz TF
  Title
Modulation of host gene expression by the K15 protein of Kaposi's sarcoma-associated herpesvirus.
  Journal
J Virol 81:42-58 (2007)
DOI:10.1128/JVI.00648-06
Reference
PMID:16585191
  Authors
Wang L, Dittmer DP, Tomlinson CC, Fakhari FD, Damania B
  Title
Immortalization of primary endothelial cells by the K1 protein of Kaposi's sarcoma-associated herpesvirus.
  Journal
Cancer Res 66:3658-66 (2006)
DOI:10.1158/0008-5472.CAN-05-3680
Reference
PMID:22521915
  Authors
Morris VA, Punjabi AS, Wells RC, Wittkopp CJ, Vart R, Lagunoff M
  Title
The KSHV viral IL-6 homolog is sufficient to induce blood to lymphatic endothelial cell differentiation.
  Journal
Virology 428:112-20 (2012)
DOI:10.1016/j.virol.2012.03.013
Reference
PMID:25594835
  Authors
Purushothaman P, Uppal T, Verma SC
  Title
Molecular biology of KSHV lytic reactivation.
  Journal
Viruses 7:116-53 (2015)
DOI:10.3390/v7010116
Reference
PMID:14991150
  Authors
Fujimuro M, Hayward SD
  Title
Manipulation of glycogen-synthase kinase-3 activity in KSHV-associated cancers.
  Journal
J Mol Med (Berl) 82:223-31 (2004)
DOI:10.1007/s00109-003-0519-7
Reference
PMID:26870016
  Authors
Purushothaman P, Dabral P, Gupta N, Sarkar R, Verma SC
  Title
KSHV Genome Replication and Maintenance.
  Journal
Front Microbiol 7:54 (2016)
DOI:10.3389/fmicb.2016.00054
Related
pathway
epz04010  MAPK signaling pathway
epz04064  NF-kappa B signaling pathway
epz04110  Cell cycle
epz04115  p53 signaling pathway
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epz04144  Endocytosis
epz04151  PI3K-Akt signaling pathway
epz04210  Apoptosis
epz04310  Wnt signaling pathway
epz04610  Complement and coagulation cascades
epz04620  Toll-like receptor signaling pathway
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KO pathway
ko05167   
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