KEGG   PATHWAY: hhv04810
Entry
hhv04810                    Pathway                                
Name
Regulation of actin cytoskeleton - Hyaena hyaena (striped hyena)
Class
Cellular Processes; Cell motility
Pathway map
hhv04810  Regulation of actin cytoskeleton
hhv04810

Other DBs
GO: 0030036
Organism
Hyaena hyaena (striped hyena) [GN:hhv]
Gene
120237558  LPAR1; lysophosphatidic acid receptor 1 [KO:K04289]
120229195  LPAR2; lysophosphatidic acid receptor 2 [KO:K04291]
120226556  LPAR4; lysophosphatidic acid receptor 4 [KO:K04275]
120220467  LPAR5; lysophosphatidic acid receptor 5 [KO:K08390]
120225423  CXCL12; stromal cell-derived factor 1 isoform X1 [KO:K10031]
120230386  CXCR4; C-X-C chemokine receptor type 4 [KO:K04189]
120228398  F2; prothrombin [KO:K01313] [EC:3.4.21.5]
120240736  F2R; proteinase-activated receptor 1 [KO:K03914]
120226896  INS; insulin [KO:K04526]
120236138  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
120234333  FGF1; fibroblast growth factor 1 isoform X1 [KO:K18496]
120238033  FGF2; LOW QUALITY PROTEIN: fibroblast growth factor 2 [KO:K18497]
120224487  FGF16; fibroblast growth factor 16 [KO:K04358]
120243219  FGF8; fibroblast growth factor 8 isoform X1 [KO:K04358]
120233064  FGF10; fibroblast growth factor 10 [KO:K04358]
120233875  FGF4; fibroblast growth factor 4 [KO:K04358]
120233886  FGF3; fibroblast growth factor 3 [KO:K04358]
120234087  FGF18; fibroblast growth factor 18 [KO:K04358]
120239484  FGF17; fibroblast growth factor 17 isoform X1 [KO:K04358]
120235046  FGF7; fibroblast growth factor 7 [KO:K04358]
120222265  FGF5; fibroblast growth factor 5 isoform X1 [KO:K04358]
120242355  FGF22; fibroblast growth factor 22 isoform X1 [KO:K04358]
120247465  FGF9; fibroblast growth factor 9 [KO:K04358]
120247728  FGF6; fibroblast growth factor 6 [KO:K04358]
120248082  FGF20; fibroblast growth factor 20 [KO:K04358]
120233885  FGF19; fibroblast growth factor 19 [KO:K22603]
120243454  FGF21; fibroblast growth factor 21 [KO:K22429]
120247734  FGF23; fibroblast growth factor 23 [KO:K22428]
120227991  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
120233377  PDGFB; platelet-derived growth factor subunit B [KO:K17386]
120223081  PDGFC; platelet-derived growth factor C isoform X1 [KO:K05450]
120246757  PDGFD; platelet-derived growth factor D [KO:K05450]
120244663  INSRR; insulin receptor-related protein [KO:K05086] [EC:2.7.10.1]
120238884  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
120238662  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
120244115  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
120231844  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
120236775  FGFR4; fibroblast growth factor receptor 4 isoform X1 [KO:K05095] [EC:2.7.10.1]
120222584  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
120236611  PDGFRB; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
120232421  FN1; fibronectin isoform X1 [KO:K05717]
120248041  ITGA1; integrin alpha-1 [KO:K06480]
120248043  ITGA2; integrin alpha-2 isoform X1 [KO:K06481]
120222277  ITGA2B; integrin alpha-IIb [KO:K06476]
120229011  ITGA3; integrin alpha-3 isoform X1 [KO:K06482]
120236690  ITGA4; integrin alpha-4 [KO:K06483]
120220031  ITGA5; integrin alpha-5 [KO:K06484]
120236401  ITGA6; integrin alpha-6 isoform X1 [KO:K06485]
120219960  ITGA7; integrin alpha-7 [KO:K06583]
120236917  ITGA8; integrin alpha-8 isoform X1 [KO:K06584]
120235085  ITGA9; integrin alpha-9 isoform X1 [KO:K06585]
120220700  ITGA10; integrin alpha-10 [KO:K06586]
120221272  ITGA11; integrin alpha-11 [KO:K06587]
120241461  ITGAV; integrin alpha-V isoform X1 [KO:K06487]
120242213  ITGAL; integrin alpha-L isoform X1 [KO:K05718]
120242238  ITGAM; integrin alpha-M [KO:K06461]
120242254  integrin alpha-X-like [KO:K06462]
120235649  LOW QUALITY PROTEIN: integrin alpha-D-like [KO:K06594]
120224766  ITGAE; LOW QUALITY PROTEIN: integrin alpha-E [KO:K06524]
120222633  ITGB1; integrin beta-1 [KO:K05719]
120248676  ITGB2; LOW QUALITY PROTEIN: integrin beta-2 [KO:K06464]
120244266  ITGB3; integrin beta-3 isoform X1 [KO:K06493]
120228176  ITGB4; integrin beta-4 isoform X1 [KO:K06525]
120245869  ITGB5; integrin beta-5 [KO:K06588]
120235312  ITGB6; integrin beta-6 isoform X1 [KO:K06589]
120247227  ITGB7; integrin beta-7 [KO:K06590]
120236225  ITGB8; integrin beta-8 isoform X1 [KO:K06591]
120238113  KNG1; kininogen-1 [KO:K03898]
120223845  BDKRB1; B1 bradykinin receptor [KO:K03915]
120223849  BDKRB2; B2 bradykinin receptor [KO:K03916]
120249162  CHRM1; muscarinic acetylcholine receptor M1 [KO:K04129]
120224207  CHRM2; muscarinic acetylcholine receptor M2 [KO:K04130]
120222084  CHRM3; muscarinic acetylcholine receptor M3 [KO:K04131]
120228491  CHRM4; muscarinic acetylcholine receptor M4 [KO:K04132]
120221102  CHRM5; muscarinic acetylcholine receptor M5 [KO:K04133]
120233401  C5; complement C5 [KO:K03994]
120233403  complement C5-like [KO:K03994]
120239772  C6; complement component C6 [KO:K03995]
120239794  C7; complement component C7 [KO:K03996]
120235666  C8A; complement component C8 alpha chain [KO:K03997]
120235446  C8B; complement component C8 beta chain [KO:K03998]
120226448  C8G; complement component C8 gamma chain [KO:K03999]
120239785  C9; complement component C9 [KO:K04000]
120228022  GNA12; guanine nucleotide-binding protein subunit alpha-12 [KO:K04346]
120230247  GNA13; guanine nucleotide-binding protein subunit alpha-13 [KO:K04639]
120220331  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
120245305  GNG14; putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347]
120226289  FGD1; FYVE, RhoGEF and PH domain-containing protein 1 isoform X1 [KO:K05720]
120219631  FGD3; FYVE, RhoGEF and PH domain-containing protein 3 isoform X1 [KO:K05722]
120232325  PTK2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
120248194  BCAR1; breast cancer anti-estrogen resistance protein 1 isoform X1 [KO:K05726]
120238810  CRKL; crk-like protein [KO:K04438]
120245519  CRK; adapter molecule crk isoform X1 [KO:K04438]
120244330  DOCK1; dedicator of cytokinesis protein 1 isoform X1 [KO:K13708]
120228611  SRC; proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
120220282  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
120244628  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
120223392  HRAS; GTPase HRas isoform X1 [KO:K02833]
120223531  KRAS; GTPase KRas [KO:K07827]
120243068  NRAS; GTPase NRas [KO:K07828]
120244187  RRAS; ras-related protein R-Ras [KO:K07829]
120244997  RRAS2; ras-related protein R-Ras2 isoform X1 [KO:K07830]
120222404  MRAS; ras-related protein M-Ras [KO:K07831]
120220130  ARHGEF6; rho guanine nucleotide exchange factor 6 isoform X1 [KO:K05729]
120233608  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
120220979  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
120246696  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
120219997  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
120239233  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
120247089  phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
120226858  VAV1; proto-oncogene vav isoform X1 [KO:K05730]
120247171  VAV3; guanine nucleotide exchange factor VAV3 [KO:K05730]
120247312  VAV2; guanine nucleotide exchange factor VAV2 isoform X1 [KO:K05730]
120229789  TIAM1; T-lymphoma invasion and metastasis-inducing protein 1 isoform X1 [KO:K05731]
120219872  ARAF; serine/threonine-protein kinase A-Raf [KO:K08845] [EC:2.7.11.1]
120232948  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
120231327  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
120222467  MOS; proto-oncogene serine/threonine-protein kinase mos [KO:K04367] [EC:2.7.11.1]
120221655  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
120242086  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
120238830  MAPK1; mitogen-activated protein kinase 1 isoform X1 [KO:K04371] [EC:2.7.11.24]
120242212  MAPK3; mitogen-activated protein kinase 3 isoform X1 [KO:K04371] [EC:2.7.11.24]
120235277  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
120244696  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
120247774  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
120248656  RGCC; regulator of cell cycle RGCC [KO:K26108]
120241163  ARHGEF1; rho guanine nucleotide exchange factor 1 isoform X1 [KO:K12330]
120229970  ARHGEF12; rho guanine nucleotide exchange factor 12 isoform X1 [KO:K07532]
120241560  ARHGAP35; rho GTPase-activating protein 35 [KO:K05732]
120229394  RHOA; transforming protein RhoA [KO:K04513]
120249159  transforming protein RhoA-like [KO:K04513]
120227958  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
120241186  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
120228188  RAC3; ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861]
120233626  cell division control protein 42 homolog [KO:K04393]
120231260  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
120229608  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
120244384  PAK2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
120241977  PAK3; serine/threonine-protein kinase PAK 3 [KO:K05733] [EC:2.7.11.1]
120242769  PAK4; serine/threonine-protein kinase PAK 4 [KO:K05734] [EC:2.7.11.1]
120226240  PAK5; serine/threonine-protein kinase PAK 5 [KO:K05736] [EC:2.7.11.1]
120232303  PAK6; serine/threonine-protein kinase PAK 6 [KO:K05735] [EC:2.7.11.1]
120228351  ARHGEF7; rho guanine nucleotide exchange factor 7 isoform X1 [KO:K13710]
120245831  GIT1; ARF GTPase-activating protein GIT1 isoform X1 [KO:K05737]
120220661  ROCK1; rho-associated protein kinase 1 isoform X1 [KO:K04514] [EC:2.7.11.1]
120231144  ROCK2; rho-associated protein kinase 2 [KO:K17388] [EC:2.7.11.1]
120237364  MYLK; myosin light chain kinase, smooth muscle isoform X1 [KO:K00907] [EC:2.7.11.18]
120238194  MYLK3; myosin light chain kinase 3 isoform X1 [KO:K00907] [EC:2.7.11.18]
120235452  MYLK2; myosin light chain kinase 2, skeletal/cardiac muscle [KO:K00907] [EC:2.7.11.18]
120241448  MYLK4; myosin light chain kinase family member 4 [KO:K00907] [EC:2.7.11.18]
120233909  PPP1CA; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
120239251  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
120235890  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit isoform X1 [KO:K06269] [EC:3.1.3.16]
120233963  PPP1R12A; protein phosphatase 1 regulatory subunit 12A isoform X1 [KO:K06270]
120228862  PPP1R12B; protein phosphatase 1 regulatory subunit 12B isoform X1 [KO:K12329]
120239719  PPP1R12C; protein phosphatase 1 regulatory subunit 12C isoform X1 [KO:K17457]
120247408  MYL2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
120222517  MYL5; myosin light chain 5 [KO:K12753]
120238920  MYL7; myosin regulatory light chain 2, atrial isoform isoform X1 [KO:K12754]
120228602  MYL9; myosin regulatory light polypeptide 9 [KO:K12755]
120239322  MYL10; myosin regulatory light chain 10 [KO:K12756]
120239085  myosin regulatory light polypeptide 9-like [KO:K12757]
120239090  myosin regulatory light chain 12B [KO:K12757]
120234698  myosin regulatory light polypeptide 9-like [KO:K12757]
120242286  MYLPF; myosin regulatory light chain 2, skeletal muscle isoform [KO:K12758]
120232697  MYH11; myosin-11 [KO:K10352]
120241162  MYH9; myosin-9 [KO:K10352]
120241792  MYH14; myosin-14 [KO:K10352]
120231384  MYH10; myosin-10 isoform X1 [KO:K10352]
120234375  DIAPH1; protein diaphanous homolog 1 isoform X1 [KO:K05740]
120224971  DIAPH2; protein diaphanous homolog 2 [KO:K05741]
120231816  SLC9A1; sodium/hydrogen exchanger 1 [KO:K05742]
120243401  PIP5K1B; phosphatidylinositol 4-phosphate 5-kinase type-1 beta [KO:K00889] [EC:2.7.1.68]
120241303  PIP5K1A; phosphatidylinositol 4-phosphate 5-kinase type-1 alpha [KO:K00889] [EC:2.7.1.68]
120242042  PIP5K1C; phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform X1 [KO:K00889] [EC:2.7.1.68]
120232357  PIP4K2A; phosphatidylinositol 5-phosphate 4-kinase type-2 alpha isoform X1 [KO:K00920] [EC:2.7.1.149]
120228979  PIP4K2B; phosphatidylinositol 5-phosphate 4-kinase type-2 beta isoform X1 [KO:K00920] [EC:2.7.1.149]
120248010  PIP4K2C; phosphatidylinositol 5-phosphate 4-kinase type-2 gamma isoform X1 [KO:K00920] [EC:2.7.1.149]
120237361  PIKFYVE; 1-phosphatidylinositol 3-phosphate 5-kinase isoform X1 [KO:K00921] [EC:2.7.1.150]
120247359  LIMK1; LIM domain kinase 1 isoform X1 [KO:K05743] [EC:2.7.11.1]
120227439  LIMK2; LIM domain kinase 2 isoform X1 [KO:K05744] [EC:2.7.11.1]
120241900  DIAPH3; protein diaphanous homolog 3 isoform X1 [KO:K05745]
120228135  BAIAP2; brain-specific angiogenesis inhibitor 1-associated protein 2 isoform X1 [KO:K05627]
120234140  ENAH; protein enabled homolog isoform X1 [KO:K05746]
120236728  WASL; neural Wiskott-Aldrich syndrome protein [KO:K23612]
120231291  WASF2; wiskott-Aldrich syndrome protein family member 2 [KO:K05748]
120243327  CYFIP2; cytoplasmic FMR1-interacting protein 2 isoform X1 [KO:K05749]
120222422  CYFIP1; cytoplasmic FMR1-interacting protein 1 isoform X1 [KO:K05749]
120220036  NCKAP1L; nck-associated protein 1-like [KO:K05750]
120236693  NCKAP1; nck-associated protein 1 [KO:K05750]
120224357  ABI2; abl interactor 2 isoform X1 [KO:K05751]
120231306  BRK1; protein BRICK1 [KO:K05752]
120225787  WASF1; wiskott-Aldrich syndrome protein family member 1 isoform X1 [KO:K05753]
120239055  ACTR2; actin-related protein 2 [KO:K17260]
120230365  ACTR3; actin-related protein 3 [KO:K18584]
120230918  ACTR3B; actin-related protein 3B isoform X1 [KO:K18584]
120227999  ARPC1A; actin-related protein 2/3 complex subunit 1A [KO:K05757]
120228025  ARPC1B; actin-related protein 2/3 complex subunit 1B [KO:K05757]
120232413  ARPC2; actin-related protein 2/3 complex subunit 2 [KO:K05758]
120247985  ARPC3; actin-related protein 2/3 complex subunit 3 [KO:K05756]
120231303  ARPC4; actin-related protein 2/3 complex subunit 4 isoform X1 [KO:K05755]
120236302  ARPC5L; actin-related protein 2/3 complex subunit 5-like protein [KO:K05754]
120245834  actin-related protein 2/3 complex subunit 5 [KO:K05754]
120245840  protein diaphanous homolog 1-like [KO:K05754]
120228024  ACTB; actin, cytoplasmic 1 [KO:K05692]
120228303  ACTG1; actin, cytoplasmic 2 [KO:K05692]
120224070  profilin-2-like [KO:K05759]
120237651  PFN2; profilin-2 isoform X1 [KO:K05759]
120235845  PFN4; profilin-4 [KO:K05759]
120236804  PFN3; profilin-3 [KO:K05759]
120246894  PFN1; profilin-1 [KO:K05759]
120230646  PXN; paxillin isoform X1 [KO:K05760]
120245160  EZR; ezrin isoform X1 [KO:K08007]
120229862  RDX; radixin isoform X1 [KO:K05762]
120224027  MSN; moesin [KO:K05763]
120233139  TMSB4X; thymosin beta-4 [KO:K05764]
120222208  thymosin beta-4-like [KO:K05764]
120247490  LOW QUALITY PROTEIN: thymosin beta-4-like [KO:K05764]
120248272  thymosin beta-4, Y-chromosomal-like [KO:K05764]
120240213  CFL1; cofilin-1 [KO:K05765]
120248603  CFL2; cofilin-2 isoform X1 [KO:K05765]
120233935  SSH3; protein phosphatase Slingshot homolog 3 isoform X1 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
120233995  SSH1; protein phosphatase Slingshot homolog 1 isoform X1 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
120245459  SSH2; protein phosphatase Slingshot homolog 2 isoform X1 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
120233762  VCL; vinculin isoform X1 [KO:K05700]
120248522  IQGAP1; ras GTPase-activating-like protein IQGAP1 [KO:K16848]
120240720  IQGAP2; ras GTPase-activating-like protein IQGAP2 isoform X1 [KO:K05767]
120244691  IQGAP3; ras GTPase-activating-like protein IQGAP3 isoform X1 [KO:K05767]
120233410  GSN; gelsolin isoform X1 [KO:K05768]
120248157  SCIN; adseverin [KO:K05768]
120237417  ACTN1; alpha-actinin-1 isoform X1 [KO:K05699]
120220627  ACTN4; alpha-actinin-4 [KO:K05699]
120242387  APC2; adenomatous polyposis coli protein 2 isoform X1 [KO:K02085]
120236758  APC; adenomatous polyposis coli protein isoform X1 [KO:K02085]
120220516  ARHGEF4; rho guanine nucleotide exchange factor 4 isoform X1 [KO:K05769]
120247506  SPATA13; spermatogenesis-associated protein 13 isoform X1 [KO:K05769]
Compound
C00681  1-Acyl-sn-glycerol 3-phosphate
C01996  Acetylcholine
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11554  1-Phosphatidyl-1D-myo-inositol 3,4-bisphosphate
Reference
PMID:14744429
  Authors
Burridge K, Wennerberg K.
  Title
Rho and Rac take center stage.
  Journal
Cell 116:167-79 (2004)
DOI:10.1016/S0092-8674(04)00003-0
Reference
PMID:11082269
  Authors
Schmitz AA, Govek EE, Bottner B, Van Aelst L.
  Title
Rho GTPases: signaling, migration, and invasion.
  Journal
Exp Cell Res 261:1-12 (2000)
DOI:10.1006/excr.2000.5049
Reference
PMID:11152757
  Authors
Takai Y, Sasaki T, Matozaki T.
  Title
Small GTP-binding proteins.
  Journal
Physiol Rev 81:153-208 (2001)
DOI:10.1152/physrev.2001.81.1.153
Reference
PMID:12700767
  Authors
Pollard TD.
  Title
The cytoskeleton, cellular motility and the reductionist agenda.
  Journal
Nature 422:741-5 (2003)
DOI:10.1038/nature01598
Reference
PMID:14657486
  Authors
Ridley AJ, Schwartz MA, Burridge K, Firtel RA, Ginsberg MH, Borisy G, Parsons JT, Horwitz AR.
  Title
Cell migration: integrating signals from front to back.
  Journal
Science 302:1704-9 (2003)
DOI:10.1126/science.1092053
Reference
PMID:11082272
  Authors
Sastry SK, Burridge K.
  Title
Focal adhesions: a nexus for intracellular signaling and cytoskeletal dynamics.
  Journal
Exp Cell Res 261:25-36 (2000)
DOI:10.1006/excr.2000.5043
Reference
PMID:10574699
  Authors
Fukata M, Nakagawa M, Kuroda S, Kaibuchi K.
  Title
Cell adhesion and Rho small GTPases.
  Journal
J Cell Sci 112 ( Pt 24):4491-500 (1999)
Related
pathway
hhv04010  MAPK signaling pathway
hhv04510  Focal adhesion
hhv04520  Adherens junction
KO pathway
ko04810   
LinkDB

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