KEGG   PATHWAY: mcal04020
Entry
mcal04020                   Pathway                                
Name
Calcium signaling pathway - Mus caroli (Ryukyu mouse)
Description
Ca2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this external source of signal Ca2+ by activating various entry channels with widely different properties. The voltage-operated channels (VOCs) are found in excitable cells and generate the rapid Ca2+ fluxes that control fast cellular processes. There are many other Ca2+-entry channels, such as the receptor-operated channels (ROCs), for example the NMDA (N-methyl-D-aspartate) receptors (NMDARs) that respond to glutamate. There also are second-messenger-operated channels (SMOCs) and store-operated channels (SOCs).
The other principal source of Ca2+ for signalling is the internal stores that are located primarily in the endoplasmic/sarcoplasmic reticulum (ER/SR), in which inositol-1,4,5-trisphosphate receptors (IP3Rs) or ryanodine receptors (RYRs) regulate the release of Ca2+. The principal activator of these channels is Ca2+ itself and this process of Ca2+-induced Ca2+ release is central to the mechanism of Ca2+ signalling. Various second messengers or modulators also control the release of Ca2+. IP3, which is generated by pathways using different isoforms of phospholipase C (PLCbeta, delta, epsilon, gamma and zeta), regulates the IP3Rs. Cyclic ADP-ribose (cADPR) releases Ca2+ via RYRs. Nicotinic acid adenine dinucleotide phosphate (NAADP) may activate a distinct Ca2+ release mechanism on separate acidic Ca2+ stores. Ca2+ release via the NAADP-sensitive mechanism may also feedback onto either RYRs or IP3Rs. cADPR and NAADP are generated by CD38. This enzyme might be sensitive to the cellular metabolism, as ATP and NADH inhibit it.
The influx of Ca2+ from the environment or release from internal stores causes a very rapid and dramatic increase in cytoplasmic calcium concentration, which has been widely exploited for signal transduction. Some proteins, such as troponin C (TnC) involved in muscle contraction, directly bind to and sense Ca2+. However, in other cases Ca2+ is sensed through intermediate calcium sensors such as calmodulin (CALM).
Class
Environmental Information Processing; Signal transduction
Pathway map
mcal04020  Calcium signaling pathway
mcal04020

Other DBs
GO: 0019722
Organism
Mus caroli (Ryukyu mouse) [GN:mcal]
Gene
110297788  Slc8a2; sodium/calcium exchanger 2 isoform X1 [KO:K05849]
110312337  Slc8a1; sodium/calcium exchanger 1 isoform X1 [KO:K05849]
110306723  Slc8a3; sodium/calcium exchanger 3 isoform X1 [KO:K05849]
110295976  Atp2b2; plasma membrane calcium-transporting ATPase 2 isoform X1 [KO:K05850] [EC:7.2.2.10]
110286561  Atp2b3; plasma membrane calcium-transporting ATPase 3 isoform X3 [KO:K05850] [EC:7.2.2.10]
110299202  Atp2b4; plasma membrane calcium-transporting ATPase 4 isoform X1 [KO:K05850] [EC:7.2.2.10]
110302903  Atp2b1; plasma membrane calcium-transporting ATPase 1 isoform X1 [KO:K05850] [EC:7.2.2.10]
110285542  Chrm1; muscarinic acetylcholine receptor M1 [KO:K04129]
110308311  Chrm3; muscarinic acetylcholine receptor M3 [KO:K04131]
110289866  Chrm5; muscarinic acetylcholine receptor M5 [KO:K04133]
110303741  Adora2a; adenosine receptor A2a [KO:K04266]
110305306  Adora2b; adenosine receptor A2b [KO:K04267]
110285631  Adrb1; beta-1 adrenergic receptor [KO:K04141]
110285060  Adrb2; beta-2 adrenergic receptor [KO:K04142]
110300707  Adrb3; beta-3 adrenergic receptor [KO:K04143]
110308359  Drd1; D(1A) dopamine receptor [KO:K04144]
110295343  Drd5; D(1B) dopamine receptor [KO:K05840]
110308572  Hrh2; histamine H2 receptor [KO:K04150]
110284712  Htr4; 5-hydroxytryptamine receptor 4 isoform X2 [KO:K04160]
110301108  5-hydroxytryptamine receptor 5B [KO:K04161]
110295389  Htr5a; 5-hydroxytryptamine receptor 5A [KO:K04161]
110293622  Htr6; 5-hydroxytryptamine receptor 6 [KO:K04162]
110285717  Htr7; 5-hydroxytryptamine receptor 7 isoform X1 [KO:K04163]
110308282  guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas isoform X1 [KO:K04632]
110308334  neuroendocrine secretory protein 55 [KO:K04632]
110284817  Gnal; guanine nucleotide-binding protein G(olf) subunit alpha isoform X1 [KO:K04633]
110305998  Adcy1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
110307661  Adcy2; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
110306494  Adcy3; adenylate cyclase type 3 isoform X2 [KO:K08043] [EC:4.6.1.1]
110309267  Adcy4; adenylate cyclase type 4 [KO:K08044] [EC:4.6.1.1]
110299719  Adcy7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
110310371  Adcy8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
110311555  Adcy9; adenylate cyclase type 9 isoform X2 [KO:K08049] [EC:4.6.1.1]
110290795  Prkacb; cAMP-dependent protein kinase catalytic subunit beta isoform X2 [KO:K04345] [EC:2.7.11.11]
110300173  Prkaca; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
110303164  Pln; cardiac phospholamban [KO:K05852]
110302592  Sln; sarcolipin [KO:K22642]
110302807  Mrln; myoregulin isoform X2 [KO:K22643]
110291667  C3H4orf3; uncharacterized protein C4orf3 homolog [KO:K26467]
110287928  uncharacterized protein C4orf3 homolog [KO:K26467]
110312321  uncharacterized protein C4orf3 homolog [KO:K26467]
110306224  Smim6; small integral membrane protein 6 [KO:K26468]
110295033  Atp2a2; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 [KO:K05853] [EC:7.2.2.10]
110304358  Atp2a3; sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform X2 [KO:K05853] [EC:7.2.2.10]
110299270  Atp2a1; sarcoplasmic/endoplasmic reticulum calcium ATPase 1 isoform X1 [KO:K05853] [EC:7.2.2.10]
110299370  Hrc; sarcoplasmic reticulum histidine-rich calcium-binding protein [KO:K23450]
110297633  Stim1; stromal interaction molecule 1 isoform X1 [KO:K16059]
110294525  Stim2; stromal interaction molecule 2 [KO:K18196]
110294733  Orai1; calcium release-activated calcium channel protein 1 [KO:K16056]
110294966  Orai2; protein orai-2 [KO:K16057]
110297805  Orai3; protein orai-3 [KO:K16058]
110295755  voltage-dependent L-type calcium channel subunit alpha-1C [KO:K04850]
110309492  Cacna1d; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
110286673  Cacna1f; voltage-dependent L-type calcium channel subunit alpha-1F [KO:K04853]
110296075  Cacna1s; voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
110299941  Cacna1a; voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform X1 [KO:K04344]
110289304  Cacna1b; voltage-dependent N-type calcium channel subunit alpha-1B isoform X5 [KO:K04849]
110292269  Cacna1e; voltage-dependent R-type calcium channel subunit alpha-1E isoform X8 [KO:K04852]
110304549  Cacna1g; voltage-dependent T-type calcium channel subunit alpha-1G [KO:K04854]
110284204  Cacna1h; voltage-dependent T-type calcium channel subunit alpha-1H isoform X2 [KO:K04855]
110310116  Cacna1i; voltage-dependent T-type calcium channel subunit alpha-1I isoform X3 [KO:K04856]
110298419  Chrna7; neuronal acetylcholine receptor subunit alpha-7 isoform X1 [KO:K04809]
110285719  Grin1; glutamate receptor ionotropic, NMDA 1 isoform X1 [KO:K05208]
110311574  Grin2a; glutamate receptor ionotropic, NMDA 2A [KO:K05209]
110296148  Grin2b; glutamate receptor ionotropic, NMDA 2B [KO:K05210]
110305122  Grin2c; glutamate receptor ionotropic, NMDA 2C [KO:K05211]
110298186  Grin2d; glutamate receptor ionotropic, NMDA 2D [KO:K05212]
110293036  Grin3a; glutamate receptor ionotropic, NMDA 3A isoform X1 [KO:K05213]
110303636  Grin3b; glutamate receptor ionotropic, NMDA 3B [KO:K05214]
110304946  P2rx1; P2X purinoceptor 1 [KO:K05215]
110294404  P2rx2; P2X purinoceptor 2 isoform X1 [KO:K05216]
110311997  P2rx3; P2X purinoceptor 3 [KO:K05217]
110294532  P2rx4; P2X purinoceptor 4 [KO:K05218]
110304945  P2rx5; P2X purinoceptor 5 isoform X1 [KO:K05219]
110311484  P2rx6; P2X purinoceptor 6 [KO:K05221]
110294271  P2rx7; P2X purinoceptor 7 isoform X1 [KO:K05220]
110299024  Ryr1; ryanodine receptor 1 [KO:K04961]
110308440  Ryr2; ryanodine receptor 2 isoform X1 [KO:K04962]
110290413  Ryr3; ryanodine receptor 3 isoform X2 [KO:K04963]
110303552  triadin [KO:K23449]
110300403  Casq1; calsequestrin-1 [KO:K23468]
110290919  Casq2; calsequestrin-2 [KO:K23445]
110293480  Asph; aspartyl/asparaginyl beta-hydroxylase isoform X15 [KO:K00476] [EC:1.14.11.16]
110287216  Cysltr1; cysteinyl leukotriene receptor 1 isoform X1 [KO:K04322]
110309771  Cysltr2; cysteinyl leukotriene receptor 2 [KO:K04323]
110296617  Chrm2; muscarinic acetylcholine receptor M2 [KO:K04130]
110309684  Adra1a; alpha-1A adrenergic receptor isoform X1 [KO:K04135]
110305584  Adra1b; alpha-1B adrenergic receptor isoform X1 [KO:K04136]
110290039  Adra1d; alpha-1D adrenergic receptor [KO:K04137]
110307911  type-1A angiotensin II receptor [KO:K04166]
110291663  Agtr1; type-1 angiotensin II receptor [KO:K04166]
110299998  Ednra; endothelin-1 receptor isoform X1 [KO:K04197]
110309107  Ednrb; endothelin receptor type B [KO:K04198]
110308051  F2r; proteinase-activated receptor 1 [KO:K03914]
110303088  Grm1; metabotropic glutamate receptor 1 isoform X1 [KO:K04603]
110298141  Grm5; metabotropic glutamate receptor 5 isoform X1 [KO:K04604]
110287261  Grpr; gastrin-releasing peptide receptor [KO:K04169]
110296677  Hrh1; histamine H1 receptor isoform X1 [KO:K04149]
110286873  Htr2c; 5-hydroxytryptamine receptor 2C [KO:K04157]
110297492  Htr2b; LOW QUALITY PROTEIN: 5-hydroxytryptamine receptor 2B [KO:K04157]
110309591  Htr2a; 5-hydroxytryptamine receptor 2A [KO:K04157]
110283830  Lhcgr; lutropin-choriogonadotropic hormone receptor isoform X1 [KO:K04248]
110290336  Ntsr1; neurotensin receptor type 1 [KO:K04211]
110296925  Oxtr; oxytocin receptor [KO:K04229]
110303254  Avpr1a; vasopressin V1a receptor [KO:K04226]
110304280  Avpr1b; vasopressin V1b receptor [KO:K04227]
110309570  Ltb4r2; leukotriene B4 receptor 2 [KO:K04297]
110293779  Ptafr; platelet-activating factor receptor [KO:K04279]
110299710  Ptger1; prostaglandin E2 receptor EP1 subtype [KO:K04258]
110291650  Ptger3; prostaglandin E2 receptor EP3 subtype isoform X1 [KO:K04260]
110291326  Ptgfr; prostaglandin F2-alpha receptor [KO:K04262]
110307526  Bdkrb1; B1 bradykinin receptor [KO:K03915]
110307378  Bdkrb2; B2 bradykinin receptor [KO:K03916]
110296393  Tacr1; substance-P receptor [KO:K04222]
110303752  Tacr2; substance-K receptor [KO:K04223]
110291438  Tacr3; neuromedin-K receptor [KO:K04224]
110303580  Tbxa2r; thromboxane A2 receptor [KO:K04264]
110300777  thyrotropin-releasing hormone receptor-like [KO:K04282]
110310834  Trhr; thyrotropin-releasing hormone receptor isoform X2 [KO:K04282]
110295105  Cckar; cholecystokinin receptor type A [KO:K04194]
110299007  Cckbr; gastrin/cholecystokinin type B receptor isoform X2 [KO:K04195]
110299256  Cxcr4; C-X-C chemokine receptor type 4 isoform X1 [KO:K04189]
110285306  guanine nucleotide-binding protein G(q) subunit alpha isoform X1 [KO:K04634]
110303103  Gna11; guanine nucleotide-binding protein subunit alpha-11 [KO:K04635]
110285572  Gna14; guanine nucleotide-binding protein subunit alpha-14 isoform X1 [KO:K04636]
110303522  Gna15; guanine nucleotide-binding protein subunit alpha-15 [KO:K04637]
110291005  Egf; pro-epidermal growth factor isoform X1 [KO:K04357]
110295684  Tgfa; protransforming growth factor alpha [KO:K08774]
110294651  Pdgfa; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
110310626  Pdgfb; platelet-derived growth factor subunit B isoform X1 [KO:K17386]
110290924  Pdgfc; platelet-derived growth factor C [KO:K05450]
110301590  Pdgfd; platelet-derived growth factor D isoform X2 [KO:K05450]
110284837  Fgf1; fibroblast growth factor 1 isoform X1 [KO:K18496]
110291557  Fgf2; fibroblast growth factor 2 [KO:K18497]
110300580  Fgf20; fibroblast growth factor 20 [KO:K04358]
110295342  Fgf5; fibroblast growth factor 5 isoform X1 [KO:K04358]
110285629  Fgf8; fibroblast growth factor 8 isoform X1 [KO:K04358]
110287226  Fgf16; fibroblast growth factor 16 [KO:K04358]
110305760  Fgf18; fibroblast growth factor 18 [KO:K04358]
110308847  Fgf17; fibroblast growth factor 17 isoform X1 [KO:K04358]
110303818  Fgf22; fibroblast growth factor 22 isoform X1 [KO:K04358]
110309422  Fgf9; fibroblast growth factor 9 [KO:K04358]
110289950  Fgf7; fibroblast growth factor 7 [KO:K04358]
110296943  Fgf6; fibroblast growth factor 6 [KO:K04358]
110299316  Fgf4; fibroblast growth factor 4 [KO:K04358]
110299386  Fgf3; fibroblast growth factor 3 [KO:K04358]
110308330  Fgf10; fibroblast growth factor 10 [KO:K04358]
110299450  Fgf19; fibroblast growth factor 19 [KO:K22603]
110299358  Fgf21; fibroblast growth factor 21 [KO:K22429]
110297028  Fgf23; fibroblast growth factor 23 [KO:K22428]
110284402  Vegfa; vascular endothelial growth factor A isoform X1 [KO:K05448]
110285510  Vegfb; vascular endothelial growth factor B isoform X1 [KO:K16858]
110287326  Vegfd; vascular endothelial growth factor D [KO:K05449]
110300171  Vegfc; vascular endothelial growth factor C [KO:K05449]
110291584  Ngf; beta-nerve growth factor [KO:K02582]
110294216  Hgf; hepatocyte growth factor isoform X1 [KO:K05460]
110301128  Mst1; LOW QUALITY PROTEIN: hepatocyte growth factor-like protein [KO:K23441]
110310770  Gdnf; glial cell line-derived neurotrophic factor isoform X1 [KO:K05452]
110304228  Egfr; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
110304771  Erbb2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
110302668  Erbb3; receptor tyrosine-protein kinase erbB-3 isoform X1 [KO:K05084] [EC:2.7.10.1]
110312376  Erbb4; receptor tyrosine-protein kinase erbB-4 isoform X1 [KO:K05085] [EC:2.7.10.1]
110295292  Pdgfra; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
110284880  Pdgfrb; platelet-derived growth factor receptor beta isoform X2 [KO:K05089] [EC:2.7.10.1]
110299550  Fgfr1; fibroblast growth factor receptor 1 isoform X2 [KO:K04362] [EC:2.7.10.1]
110299396  Fgfr2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
110293909  Fgfr3; fibroblast growth factor receptor 3 isoform X8 [KO:K05094] [EC:2.7.10.1]
110307648  Fgfr4; fibroblast growth factor receptor 4 isoform X1 [KO:K05095] [EC:2.7.10.1]
110294038  Flt1; vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
110304471  Flt4; vascular endothelial growth factor receptor 3 [KO:K05097] [EC:2.7.10.1]
110294607  Kdr; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
110290875  Ntrk1; high affinity nerve growth factor receptor isoform X1 [KO:K03176] [EC:2.7.10.1]
110307883  Ntrk2; BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
110297619  Ntrk3; NT-3 growth factor receptor isoform X5 [KO:K05101] [EC:2.7.10.1]
110295947  Met; hepatocyte growth factor receptor isoform X2 [KO:K05099] [EC:2.7.10.1]
110301634  Mst1r; macrophage-stimulating protein receptor isoform X2 [KO:K05100] [EC:2.7.10.1]
110295751  Ret; proto-oncogene tyrosine-protein kinase receptor Ret [KO:K05126] [EC:2.7.10.1]
110305200  Plcd3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 isoform X1 [KO:K05857] [EC:3.1.4.11]
110301135  Plcd1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 isoform X2 [KO:K05857] [EC:3.1.4.11]
110293847  Plcd4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 isoform X1 [KO:K05857] [EC:3.1.4.11]
110285320  Plcb3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform X1 [KO:K05858] [EC:3.1.4.11]
110290514  Plcb4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
110286326  Plcb2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11]
110308867  Plcb1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X2 [KO:K05858] [EC:3.1.4.11]
110290454  Plcg1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 [KO:K01116] [EC:3.1.4.11]
110300336  Plcg2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 isoform X1 [KO:K05859] [EC:3.1.4.11]
110285551  Plce1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X5 [KO:K05860] [EC:3.1.4.11]
110296889  Plcz1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 isoform X1 [KO:K05861] [EC:3.1.4.11]
110296867  Itpr1; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
110295833  Itpr2; inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
110312193  Itpr3; inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
110294426  Cd38; ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 [KO:K01242] [EC:3.2.2.6 2.4.99.20]
110294094  Tpcn1; two pore calcium channel protein 1 isoform X1 [KO:K16896]
110298277  Tpcn2; two pore calcium channel protein 2 [KO:K14077]
110299770  Mcoln1; mucolipin-1 [KO:K04992]
110291215  Mcoln2; mucolipin-2 isoform X1 [KO:K04993]
110291344  Mcoln3; mucolipin-3 isoform X2 [KO:K04994]
110297874  Sphk2; sphingosine kinase 2 [KO:K04718] [EC:2.7.1.91]
110305526  Sphk1; sphingosine kinase 1 isoform X1 [KO:K04718] [EC:2.7.1.91]
110302688  Mcu; calcium uniporter protein, mitochondrial [KO:K20858]
110294695  LOW QUALITY PROTEIN: voltage-dependent anion-selective channel protein 1-like [KO:K05862]
110304481  Vdac1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
110309560  Vdac2; voltage-dependent anion-selective channel protein 2 [KO:K15040]
110300156  Vdac3; voltage-dependent anion-selective channel protein 3 [KO:K15041]
110286753  Slc25a5; ADP/ATP translocase 2 [KO:K05863]
110300115  Slc25a4; ADP/ATP translocase 1 [KO:K05863]
110291352  Slc25a31; ADP/ATP translocase 4 [KO:K05863]
110309240  Ppif; peptidyl-prolyl cis-trans isomerase F, mitochondrial [KO:K09565] [EC:5.2.1.8]
110309752  Tnnc1; troponin C, slow skeletal and cardiac muscles [KO:K05865]
110289862  Tnnc2; troponin C, skeletal muscle [KO:K12042]
110286675  calmodulin-alpha-like [KO:K02183]
110308577  Calml3; calmodulin-like protein 3 [KO:K02183]
110308601  calmodulin-4 [KO:K02183]
110286582  calmodulin [KO:K02183]
110306434  Calm1; calmodulin-1 [KO:K02183]
110302040  Calml4; calmodulin-like protein 4 isoform X2 [KO:K02183]
110297869  Calm3; calmodulin-3 [KO:K02183]
110294847  calmodulin-like [KO:K02183]
110312637  Calm2; calmodulin-2 [KO:K02183]
110294811  Phkg1; phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform isoform X1 [KO:K00871] [EC:2.7.11.19]
110298655  Phkg2; phosphorylase b kinase gamma catalytic chain, liver/testis isoform isoform X1 [KO:K00871] [EC:2.7.11.19]
110286481  Phka1; phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform isoform X1 [KO:K07190]
110286645  Phka2; phosphorylase b kinase regulatory subunit alpha, liver isoform isoform X1 [KO:K07190]
110299875  Phkb; phosphorylase b kinase regulatory subunit beta isoform X2 [KO:K07190]
110308670  myosin light chain kinase, smooth muscle isoform X1 [KO:K00907] [EC:2.7.11.18]
110290127  Mylk2; myosin light chain kinase 2, skeletal/cardiac muscle isoform X1 [KO:K00907] [EC:2.7.11.18]
110300419  Mylk3; myosin light chain kinase 3 isoform X1 [KO:K00907] [EC:2.7.11.18]
110311174  Mylk; myosin light chain kinase, smooth muscle [KO:K00907] [EC:2.7.11.18]
110299437  Camk1g; calcium/calmodulin-dependent protein kinase type 1G [KO:K08794] [EC:2.7.11.17]
110296113  Camk1; calcium/calmodulin-dependent protein kinase type 1 [KO:K08794] [EC:2.7.11.17]
110309790  Camk2g; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X5 [KO:K04515] [EC:2.7.11.17]
110305925  Camk2b; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X5 [KO:K04515] [EC:2.7.11.17]
110290827  Camk2d; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X3 [KO:K04515] [EC:2.7.11.17]
110284502  Camk2a; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
110284636  Camk4; calcium/calmodulin-dependent protein kinase type IV isoform X2 [KO:K05869] [EC:2.7.11.17]
110309045  Ppp3cb; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
110309273  Ppp3cc; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
110290686  Ppp3ca; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X2 [KO:K04348] [EC:3.1.3.16]
110304839  Ppp3r1; calcineurin subunit B type 1 [KO:K06268]
110293037  Ppp3r2; calcineurin subunit B type 2 [KO:K06268]
110312421  Tfeb; transcription factor EB isoform X1 [KO:K15590]
110284760  Nfatc1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X2 [KO:K04446]
110308382  Nfatc2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332]
110299723  Nfatc3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
110309052  Nfatc4; nuclear factor of activated T-cells, cytoplasmic 4 isoform X1 [KO:K17334]
110294416  Nos1; nitric oxide synthase, brain isoform X2 [KO:K13240] [EC:1.14.13.39]
110304621  Nos2; nitric oxide synthase, inducible [KO:K13241] [EC:1.14.13.39]
110293897  Nos3; nitric oxide synthase, endothelial isoform X1 [KO:K13242] [EC:1.14.13.39]
110310430  Pde1b; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B isoform X1 [KO:K13755] [EC:3.1.4.17]
110285248  Pde1a; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform X2 [KO:K13755] [EC:3.1.4.17]
110295911  Pde1c; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform X4 [KO:K13755] [EC:3.1.4.17]
110308944  Ptk2b; protein-tyrosine kinase 2-beta isoform X1 [KO:K05871] [EC:2.7.10.2]
110289752  Itpka; inositol-trisphosphate 3-kinase A [KO:K00911] [EC:2.7.1.127]
110298383  Itpkc; inositol-trisphosphate 3-kinase C [KO:K00911] [EC:2.7.1.127]
110289811  Itpkb; inositol-trisphosphate 3-kinase B [KO:K00911] [EC:2.7.1.127]
110304357  Prkca; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
110297826  Prkcb; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
110297763  Prkcg; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
Compound
C00002  ATP
C00004  NADH
C00076  Calcium cation
C00165  Diacylglycerol
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01330  Sodium cation
C06124  Sphingosine 1-phosphate
C11556  1-Phosphatidyl-1D-myo-inositol 3,5-bisphosphate
C13050  Cyclic ADP-ribose
C13051  Nicotinic acid adenine dinucleotide phosphate
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Nat Rev Mol Cell Biol 4:517-29 (2003)
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J Biol Chem 272:19125-32 (1997)
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Reference
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Inositol 1, 4, 5-trisphosphate receptor-mediated Ca2+ signaling in the brain.
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J Neurochem 64:953-60 (1995)
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Structures and activities of cyclic ADP-ribose, NAADP and their metabolic enzymes.
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Mol Cell Biochem 193:89-98 (1999)
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Sphingosine 1-phosphate, sphingosine kinase and autocrine calcium signalling in thyroid cells.
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Acta Physiol (Oxf) 204:151-7 (2012)
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Immunodeficiency due to defects in store-operated calcium entry.
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Ann N Y Acad Sci 1238:74-90 (2011)
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STIM1/Orai1-mediated store-operated Ca2+ entry: the tip of the iceberg.
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The acid test: the discovery of two-pore channels (TPCs) as NAADP-gated endolysosomal Ca(2+) release channels.
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Pflugers Arch 458:869-76 (2009)
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Ca(2+) signaling in striated muscle: the elusive roles of triadin, junctin, and calsequestrin.
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Eur Biophys J 39:27-36 (2009)
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Triadin regulation of the ryanodine receptor complex.
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J Physiol 593:3261-6 (2015)
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Histidine-rich calcium binding protein: the new regulator of sarcoplasmic reticulum calcium cycling.
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J Mol Cell Cardiol 50:43-9 (2011)
DOI:10.1016/j.yjmcc.2010.08.021
Related
pathway
mcal04010  MAPK signaling pathway
mcal04070  Phosphatidylinositol signaling system
mcal04210  Apoptosis
mcal04720  Long-term potentiation
mcal04730  Long-term depression
KO pathway
ko04020   
LinkDB

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