Entry
Name
Cytokine-cytokine receptor interaction - Myotis lucifugus (little brown bat)
Description
Cytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell growth, differentiation, cell death, angiogenesis, and development and repair processes aimed at the restoration of homeostasis. Cytokines are released by various cells in the body, usually in response to an activating stimulus, and they induce responses through binding to specific receptors on the cell surface of target cells. Cytokines can be grouped by structure into different families and their receptors can likewise be grouped.
Class
Environmental Information Processing; Signaling molecules and interaction
BRITE hierarchy
Pathway map
mlf04060 Cytokine-cytokine receptor interaction
Ortholog table
Organism
Myotis lucifugus (little brown bat) [GN:
mlf ]
Gene
102428104 CSF2; granulocyte-macrophage colony-stimulating factor [KO:K05427 ]
102431417 CLCF1; cardiotrophin-like cytokine factor 1 isoform X2 [KO:K05421 ]
102428427 IL1RN; interleukin-1 receptor antagonist protein isoform X1 [KO:K05481 ]
102417863 TNFSF14; tumor necrosis factor ligand superfamily member 14 [KO:K05477 ]
102439228 FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389 ]
102423814 TNFSF15; tumor necrosis factor ligand superfamily member 15 [KO:K05478 ]
102441820 TNFSF10; tumor necrosis factor ligand superfamily member 10 isoform X1 [KO:K04721 ]
102427077 TNFSF11; tumor necrosis factor ligand superfamily member 11 [KO:K05473 ]
102424993 TNFSF12; LOW QUALITY PROTEIN: tumor necrosis factor ligand superfamily member 12 [KO:K05474 ]
102424122 TNFSF8; tumor necrosis factor ligand superfamily member 8 [KO:K05471 ]
102421506 TNFSF9; LOW QUALITY PROTEIN: tumor necrosis factor ligand superfamily member 9 [KO:K05472 ]
102440688 TNFSF4; tumor necrosis factor ligand superfamily member 4 [KO:K05469 ]
102440489 TNFSF18; tumor necrosis factor ligand superfamily member 18 isoform X2 [KO:K05479 ]
102425311 TNFSF13; tumor necrosis factor ligand superfamily member 13 isoform X2 [KO:K05475 ]
102429981 TNFSF13B; tumor necrosis factor ligand superfamily member 13B [KO:K05476 ]
102438312 LOW QUALITY PROTEIN: growth/differentiation factor 8-like [KO:K05497 ]
102427988 BMP2; LOW QUALITY PROTEIN: bone morphogenetic protein 2 [KO:K21283 ]
102431317 GDF6; LOW QUALITY PROTEIN: growth/differentiation factor 6 [KO:K20012 ]
106697687 GDF7; LOW QUALITY PROTEIN: growth/differentiation factor 7 [KO:K20013 ]
102423385 LOW QUALITY PROTEIN: bone morphogenetic protein 15-like [KO:K05498 ]
102417407 CCR10; LOW QUALITY PROTEIN: C-C chemokine receptor type 10 [KO:K04185 ]
102420320 IL2RB; LOW QUALITY PROTEIN: interleukin-2 receptor subunit beta [KO:K05069 ]
102436222 IL4R; interleukin-4 receptor subunit alpha isoform X1 [KO:K05071 ]
102443288 IL15RA; interleukin-15 receptor subunit alpha isoform X7 [KO:K05074 ]
102424341 IL5RA; LOW QUALITY PROTEIN: interleukin-5 receptor subunit alpha [KO:K05067 ]
102427246 CSF3R; granulocyte colony-stimulating factor receptor isoform X1 [KO:K05061 ]
102438125 IL6R; LOW QUALITY PROTEIN: interleukin-6 receptor subunit alpha [KO:K05055 ]
102423311 IL11RA; interleukin-11 receptor subunit alpha isoform X1 [KO:K05056 ]
102442707 IL27RA; LOW QUALITY PROTEIN: interleukin-27 receptor subunit alpha [KO:K19598 ]
102425894 CNTFR; ciliary neurotrophic factor receptor subunit alpha [KO:K05059 ]
102433573 OSMR; LOW QUALITY PROTEIN: oncostatin-M-specific receptor subunit beta [KO:K05057 ]
102440341 IL20RA; LOW QUALITY PROTEIN: interleukin-20 receptor subunit alpha [KO:K05136 ]
102437241 IL20RB; interleukin-20 receptor subunit beta isoform X3 [KO:K05137 ]
102432643 IL22RA1; LOW QUALITY PROTEIN: interleukin-22 receptor subunit alpha-1 [KO:K05138 ]
102419381 IFNAR2; LOW QUALITY PROTEIN: interferon alpha/beta receptor 2 [KO:K05131 ]
102421835 IL1RAP; interleukin-1 receptor accessory protein isoform X1 [KO:K04723 ]
102436410 IL18RAP; interleukin-18 receptor accessory protein isoform X1 [KO:K05174 ]
102419664 TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158 ]
102429153 TNFRSF1B; LOW QUALITY PROTEIN: tumor necrosis factor receptor superfamily member 1B [KO:K05141 ]
102420191 LTBR; LOW QUALITY PROTEIN: tumor necrosis factor receptor superfamily member 3 [KO:K03159 ]
102423379 tumor necrosis factor receptor superfamily member 14 isoform X2 [KO:K05152 ]
102429397 tumor necrosis factor receptor superfamily member 14-like [KO:K05152 ]
106695795 tumor necrosis factor receptor superfamily member 14-like [KO:K05152 ]
102433010 TNFRSF6B; tumor necrosis factor receptor superfamily member 6B isoform X1 [KO:K05143 ]
102433075 FAS; tumor necrosis factor receptor superfamily member 6 [KO:K04390 ]
102424229 TNFRSF10A; tumor necrosis factor receptor superfamily member 10A [KO:K04722 ]
102431090 TNFRSF21; tumor necrosis factor receptor superfamily member 21 [KO:K05157 ]
102436635 EDAR; tumor necrosis factor receptor superfamily member EDAR [KO:K05162 ]
102429449 EDA2R; tumor necrosis factor receptor superfamily member 27 isoform X3 [KO:K05163 ]
102420805 NGFR; LOW QUALITY PROTEIN: tumor necrosis factor receptor superfamily member 16 [KO:K02583 ]
102442319 TNFRSF11B; tumor necrosis factor receptor superfamily member 11B [KO:K05148 ]
102442443 TNFRSF11A; tumor necrosis factor receptor superfamily member 11A [KO:K05147 ]
102435123 TNFRSF12A; tumor necrosis factor receptor superfamily member 12A [KO:K05149 ]
102429967 TNFRSF8; tumor necrosis factor receptor superfamily member 8 [KO:K05145 ]
102439545 CD40; tumor necrosis factor receptor superfamily member 5 [KO:K03160 ]
102443254 TNFRSF9; tumor necrosis factor receptor superfamily member 9 [KO:K05146 ]
102425762 tumor necrosis factor receptor superfamily member 4-like [KO:K05142 ]
102418789 TNFRSF17; tumor necrosis factor receptor superfamily member 17 isoform X1 [KO:K05153 ]
102433106 TNFRSF19; tumor necrosis factor receptor superfamily member 19 [KO:K05155 ]
102442601 RELT; tumor necrosis factor receptor superfamily member 19L isoform X1 [KO:K05156 ]
102441555 LOW QUALITY PROTEIN: tumor necrosis factor receptor superfamily member 19L-like [KO:K05156 ]
Reference
Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
Journal
Reference
Authors
Brocker C, Thompson D, Matsumoto A, Nebert DW, Vasiliou V
Title
Evolutionary divergence and functions of the human interleukin (IL) gene family.
Journal
Reference
Authors
Akdis M, Aab A, Altunbulakli C, Azkur K, Costa RA, Crameri R, Duan S, Eiwegger T, Eljaszewicz A, Ferstl R, Frei R, Garbani M, Globinska A, Hess L, Huitema C, Kubo T, Komlosi Z, Konieczna P, Kovacs N, Kucuksezer UC, Meyer N, Morita H, Olzhausen J, O'Mahony L, Pezer M, Prati M, Rebane A, Rhyner C, Rinaldi A, Sokolowska M, Stanic B, Sugita K, Treis A, van de Veen W, Wanke K, Wawrzyniak M, Wawrzyniak P, Wirz OF, Zakzuk JS, Akdis CA
Title
Interleukins (from IL-1 to IL-38), interferons, transforming growth factor beta, and TNF-alpha: Receptors, functions, and roles in diseases.
Journal
Reference
Authors
Boulanger MJ, Garcia KC
Title
Shared cytokine signaling receptors: structural insights from the gp130 system.
Journal
Reference
Authors
Allan SM, Tyrrell PJ, Rothwell NJ
Title
Interleukin-1 and neuronal injury.
Journal
Reference
Authors
Lopetuso LR, Chowdhry S, Pizarro TT
Title
Opposing Functions of Classic and Novel IL-1 Family Members in Gut Health and Disease.
Journal
Reference
Authors
Iwakura Y, Ishigame H, Saijo S, Nakae S
Title
Functional specialization of interleukin-17 family members.
Journal
Reference
Authors
Fischer P, Hilfiker-Kleiner D
Title
Survival pathways in hypertrophy and heart failure: the gp130-STAT3 axis.
Journal
Reference
Authors
Richards CD
Title
The enigmatic cytokine oncostatin m and roles in disease.
Journal
Reference
Authors
Zhang Q, Putheti P, Zhou Q, Liu Q, Gao W
Title
Structures and biological functions of IL-31 and IL-31 receptors.
Journal
Reference
Authors
Meenhuis A, Verwijmeren C, Roovers O, Touw IP
Title
The deubiquitinating enzyme DUB2A enhances CSF3 signalling by attenuating lysosomal routing of the CSF3 receptor.
Journal
Reference
Authors
de Weerd NA, Nguyen T
Title
The interferons and their receptors--distribution and regulation.
Journal
Reference
Authors
Aggarwal BB
Title
Signalling pathways of the TNF superfamily: a double-edged sword.
Journal
Reference
Authors
Ashkenazi A
Title
Targeting death and decoy receptors of the tumour-necrosis factor superfamily.
Journal
Reference
Authors
Seeger P, Musso T, Sozzani S
Title
The TGF-beta superfamily in dendritic cell biology.
Journal
Reference
Authors
Wakefield LM, Hill CS
Title
Beyond TGFbeta: roles of other TGFbeta superfamily members in cancer.
Journal
Reference
Authors
Mueller TD, Nickel J
Title
Promiscuity and specificity in BMP receptor activation.
Journal
KO pathway
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