KEGG   PATHWAY: mlx05132
Entry
mlx05132                    Pathway                                
Name
Salmonella infection - Mirounga leonina (Southern elephant seal)
Description
Salmonella infection usually presents as a self-limiting gastroenteritis or the more severe typhoid fever and bacteremia. The common disease-causing Salmonella species in human is a single species, Salmonella enterica, which has numerous serovars.
Following intestinal colonization Salmonella inject effector proteins into the host cells using a type III secretion system (T3SS), T3SS1. Then a small group of effector proteins induce rearrangement of the actin cytoskeleton resulting in membrane ruffles and rapid internalization of the bacteria.The T3SS2 is responsible for translocating effector proteins that direct Salmonella-containing vacuole (SCV) maturation. The majority of the bacteria are known to survive and replicate in SCV.
Class
Human Diseases; Infectious disease: bacterial
Pathway map
mlx05132  Salmonella infection
mlx05132

Organism
Mirounga leonina (Southern elephant seal) [GN:mlx]
Gene
118021099  PODXL; podocalyxin [KO:K06817]
118014237  PTPRC; receptor-type tyrosine-protein phosphatase C isoform X1 [KO:K06478] [EC:3.1.3.48]
118003146  RAB5A; ras-related protein Rab-5A [KO:K07887]
118008733  RAB5B; ras-related protein Rab-5B isoform X1 [KO:K07888]
118024904  RAB5C; ras-related protein Rab-5C [KO:K07889]
118004647  PIK3C3; phosphatidylinositol 3-kinase catalytic subunit type 3 [KO:K00914] [EC:2.7.1.137]
118005771  RAB7A; ras-related protein Rab-7a [KO:K07897]
118014132  RAB7B; ras-related protein Rab-7b [KO:K07898]
118025162  PLEKHM1; pleckstrin homology domain-containing family M member 1 [KO:K23282]
118013302  VPS11; vacuolar protein sorting-associated protein 11 homolog [KO:K20179]
118011311  VPS16; vacuolar protein sorting-associated protein 16 homolog isoform X1 [KO:K20180]
118003174  VPS18; vacuolar protein sorting-associated protein 18 homolog isoform X1 [KO:K20181]
118018425  VPS33A; vacuolar protein sorting-associated protein 33A [KO:K20182]
118003459  VPS39; vam6/Vps39-like protein [KO:K20183]
118024556  VPS41; vacuolar protein sorting-associated protein 41 homolog isoform X1 [KO:K20184]
118025219  RILP; rab-interacting lysosomal protein isoform X1 [KO:K13883]
118002341  DYNC1H1; cytoplasmic dynein 1 heavy chain 1 [KO:K10413]
118013158  DYNC2H1; cytoplasmic dynein 2 heavy chain 1 isoform X1 [KO:K10414]
118012335  DYNC1I2; cytoplasmic dynein 1 intermediate chain 2 isoform X1 [KO:K10415]
118020788  DYNC1I1; cytoplasmic dynein 1 intermediate chain 1 [KO:K10415]
118023705  DYNC1LI2; cytoplasmic dynein 1 light intermediate chain 2 [KO:K10416]
118002594  DYNC1LI1; cytoplasmic dynein 1 light intermediate chain 1 [KO:K10416]
118008190  DYNC2LI1; cytoplasmic dynein 2 light intermediate chain 1 isoform X1 [KO:K10417]
118024709  DYNLL2; dynein light chain 2, cytoplasmic [KO:K10418]
118018549  DYNLL1; dynein light chain 1, cytoplasmic [KO:K10418]
118026827  dynein light chain 1, cytoplasmic-like [KO:K10418]
118023833  DYNLRB2; dynein light chain roadblock-type 2 [KO:K10419]
118011400  DYNLRB1; dynein light chain roadblock-type 1 isoform X1 [KO:K10419]
118001845  dynein light chain Tctex-type 1 [KO:K10420]
118001967  dynein light chain Tctex-type 1 isoform X1 [KO:K10420]
118009169  DYNLT3; dynein light chain Tctex-type 3 isoform X1 [KO:K10420]
118007958  DCTN1; dynactin subunit 1 isoform X1 [KO:K04648]
118008671  DCTN2; dynactin subunit 2 isoform X1 [KO:K10424]
118018001  DCTN3; dynactin subunit 3 isoform X1 [KO:K10425]
118006697  dynactin subunit 4 [KO:K10426]
118006818  DCTN4; dynactin subunit 4 [KO:K10426]
117999127  DCTN5; dynactin subunit 5 [KO:K10427]
118009998  DCTN6; dynactin subunit 6 [KO:K10428]
118008216  ACTR1B; beta-centractin [KO:K16575]
118025544  ACTR1A; alpha-centractin [KO:K16575]
118002312  ACTR10; actin-related protein 10 [KO:K16576]
118008882  tubulin alpha-1B chain [KO:K07374]
118008883  tubulin alpha-1A chain [KO:K07374]
118008885  TUBA1C; tubulin alpha-1C chain [KO:K07374]
118025829  TUBA8; tubulin alpha-8 chain isoform X1 [KO:K07374]
118012024  tubulin alpha-4A chain [KO:K07374]
118014190  tubulin alpha-8 chain-like [KO:K07374]
117999803  tubulin alpha-3 chain-like [KO:K07374]
117999807  tubulin alpha-3 chain [KO:K07374]
118021622  TUBAL3; tubulin alpha chain-like 3 [KO:K07374]
118023396  tubulin beta-3 chain [KO:K07375]
118016456  TUBB6; tubulin beta-6 chain [KO:K07375]
118024014  TUBB1; tubulin beta-1 chain [KO:K07375]
118017483  TUBB4B; tubulin beta-4B chain [KO:K07375]
118005105  TUBB4A; tubulin beta-4A chain [KO:K07375]
118027362  TUBB; tubulin beta chain [KO:K07375]
118027399  tubulin beta-2A chain-like [KO:K07375]
118027402  TUBB2B; tubulin beta-2B chain [KO:K07375]
118005720  FYCO1; FYVE and coiled-coil domain-containing protein 1 [KO:K21954]
118006044  ARL8B; ADP-ribosylation factor-like protein 8B [KO:K07955]
118014198  ARL8A; ADP-ribosylation factor-like protein 8A isoform X1 [KO:K07955]
118019971  PLEKHM2; pleckstrin homology domain-containing family M member 2 isoform X1 [KO:K15348]
118008426  KIF5A; kinesin heavy chain [KO:K10396]
118012462  KIF5C; kinesin heavy chain [KO:K10396]
117998425  KIF5B; kinesin-1 heavy chain isoform X1 [KO:K10396]
118001187  KLC4; kinesin light chain 4 isoform X1 [KO:K10407]
118016083  KLC2; kinesin light chain 2 [KO:K10407]
118002576  KLC1; kinesin light chain 1 isoform X1 [KO:K10407]
117998137  KLC3; kinesin light chain 3 [KO:K10407]
118013017  ACBD3; Golgi resident protein GCP60 isoform X1 [KO:K23935]
118005670  RHOA; transforming protein RhoA [KO:K04513]
118025693  M6PR; cation-dependent mannose-6-phosphate receptor isoform X1 [KO:K10089]
118009207  LOW QUALITY PROTEIN: ras-related protein Rab-9A-like [KO:K07899]
118026738  RAB9A; ras-related protein Rab-9A [KO:K07899]
118019330  RAB9B; ras-related protein Rab-9B [KO:K07900]
118008293  GCC2; GRIP and coiled-coil domain-containing protein 2 [KO:K20282]
118004941  STX10; syntaxin-10 isoform X1 [KO:K23937]
117999955  PFN1; profilin-1 [KO:K05759]
118015790  PFN3; profilin-3 [KO:K05759]
118009957  profilin-2-like [KO:K05759]
118005144  PFN2; profilin-2 isoform X1 [KO:K05759]
118007403  PFN4; profilin-4 [KO:K05759]
118014658  FLNA; filamin-A isoform X1 [KO:K04437]
118024245  EXOC7; exocyst complex component 7 isoform X1 [KO:K07195]
118002334  EXOC5; exocyst complex component 5 isoform X1 [KO:K19984]
118021105  EXOC4; exocyst complex component 4 [KO:K06111]
118027383  EXOC2; exocyst complex component 2 isoform X1 [KO:K17637]
118024553  RALA; ras-related protein Ral-A [KO:K07834]
118024176  ACTG1; actin, cytoplasmic 2 [KO:K05692]
117999316  ACTB; actin, cytoplasmic 1 [KO:K05692]
118022157  protein S100-A10-like [KO:K17274]
118000363  S100A10; protein S100-A10 [KO:K17274]
118016511  protein S100-A10-like [KO:K17274]
118007486  protein S100-A10-like [KO:K17274]
118003374  ANXA2; annexin A2 [KO:K17092]
118013196  annexin A2-like [KO:K17092]
118006431  annexin A2-like [KO:K17092]
118006562  annexin A2-like [KO:K17092]
118002363  RHOJ; rho-related GTP-binding protein RhoJ [KO:K07864]
118005480  ARHGEF26; rho guanine nucleotide exchange factor 26 isoform X1 [KO:K13744]
118003868  RHOG; rho-related GTP-binding protein RhoG [KO:K07863]
118026023  rho-related GTP-binding protein RhoG-like [KO:K07863]
118020970  ELMO1; engulfment and cell motility protein 1 isoform X1 [KO:K12366]
118011556  ELMO2; engulfment and cell motility protein 2 [KO:K18985]
118007595  ROCK2; rho-associated protein kinase 2 isoform X1 [KO:K17388] [EC:2.7.11.1]
118018471  MYL2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform isoform X1 [KO:K10351]
118010819  MYL5; myosin light chain 5 isoform X1 [KO:K12753]
118024560  MYL7; myosin regulatory light chain 2, atrial isoform [KO:K12754]
118011444  MYL9; myosin regulatory light polypeptide 9 [KO:K12755]
117999242  MYL10; myosin regulatory light chain 10 [KO:K12756]
118024266  myosin regulatory light chain 12A-like [KO:K12757]
118004378  myosin regulatory light polypeptide 9 isoform X1 [KO:K12757]
118004379  myosin regulatory light chain 12B [KO:K12757]
117999604  MYLPF; myosin regulatory light chain 2, skeletal muscle isoform [KO:K12758]
118023678  FHOD1; FH1/FH2 domain-containing protein 1 isoform X1 [KO:K23938]
118011345  cell division control protein 42 homolog [KO:K04393]
118004774  cell division control protein 42 homolog [KO:K04393]
118019913  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
118018155  LOW QUALITY PROTEIN: ras-related C3 botulinum toxin substrate 1-like [KO:K04392]
117999338  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
118008755  NCKAP1L; nck-associated protein 1-like isoform X1 [KO:K05750]
118012247  NCKAP1; nck-associated protein 1 isoform X1 [KO:K05750]
118022944  CYFIP1; cytoplasmic FMR1-interacting protein 1 isoform X1 [KO:K05749]
118016004  CYFIP2; cytoplasmic FMR1-interacting protein 2 isoform X1 [KO:K05749]
118026569  ABI1; abl interactor 1 [KO:K23649]
118000373  probable protein BRICK1 [KO:K05752]
118005097  BRK1; protein BRICK1 [KO:K05752]
117999002  probable protein BRICK1 [KO:K05752]
118009565  WASF3; wiskott-Aldrich syndrome protein family member 3 isoform X1 [KO:K06083]
118008048  ACTR2; actin-related protein 2 isoform X1 [KO:K17260]
118026829  ACTR3B; actin-related protein 3B isoform X1 [KO:K18584]
118012523  ACTR3; actin-related protein 3 [KO:K18584]
118020689  actin-related protein 2/3 complex subunit 1A-like [KO:K05757]
117999364  ARPC1A; actin-related protein 2/3 complex subunit 1A [KO:K05757]
117999367  ARPC1B; actin-related protein 2/3 complex subunit 1B [KO:K05757]
118026076  LOW QUALITY PROTEIN: actin-related protein 2/3 complex subunit 2-like [KO:K05758]
118012053  ARPC2; actin-related protein 2/3 complex subunit 2 [KO:K05758]
118001060  actin-related protein 2/3 complex subunit 3-like [KO:K05756]
118017874  actin-related protein 2/3 complex subunit 3 [KO:K05756]
118018453  ARPC3; actin-related protein 2/3 complex subunit 3 isoform X1 [KO:K05756]
117998914  actin-related protein 2/3 complex subunit 3-like [KO:K05756]
118005822  ARPC4; actin-related protein 2/3 complex subunit 4 [KO:K05755]
118017688  ARPC5L; actin-related protein 2/3 complex subunit 5-like protein [KO:K05754]
118014382  ARPC5; actin-related protein 2/3 complex subunit 5 [KO:K05754]
118004217  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
118012112  PAK3; serine/threonine-protein kinase PAK 3 [KO:K05733] [EC:2.7.11.1]
118001260  MYO6; unconventional myosin-VI isoform X1 [KO:K10358]
118004424  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
118020028  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
118006556  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
118020625  PIK3CG; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform isoform X1 [KO:K21289] [EC:2.7.1.153]
118025609  PIK3C2G; phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma isoform X1 [KO:K00923] [EC:2.7.1.154]
118004232  PIK3C2A; phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha [KO:K00923] [EC:2.7.1.154]
118014159  PIK3C2B; phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta isoform X1 [KO:K00923] [EC:2.7.1.154]
118024208  CYTH1; cytohesin-1 isoform X1 [KO:K18441]
117998222  CYTH2; cytohesin-2 [KO:K18441]
117998714  CYTH4; cytohesin-4 [KO:K18441]
117999340  CYTH3; cytohesin-3 isoform X1 [KO:K18441]
118002026  ARF6; ADP-ribosylation factor 6 isoform X1 [KO:K07941]
118026885  ARF1; ADP-ribosylation factor 1 [KO:K07937]
118027176  ARL17A; ADP-ribosylation factor-like 17-like [KO:K07937]
117997719  ADP-ribosylation factor 1-like [KO:K07937]
118001802  sorting nexin-9 [KO:K17923]
118001925  sorting nexin-9 [KO:K17923]
118003345  SNX33; sorting nexin-33 isoform X1 [KO:K17923]
118006684  sorting nexin-18 isoform X1 [KO:K17923]
118006805  sorting nexin-18 [KO:K17923]
118021039  WASL; neural Wiskott-Aldrich syndrome protein [KO:K23612]
118005672  DNM2; dynamin-2 isoform X1 [KO:K23484] [EC:3.6.5.5]
118010615  TLR6; toll-like receptor 6 [KO:K10169]
118022230  TLR2; toll-like receptor 2 [KO:K10159]
118022538  LOW QUALITY PROTEIN: toll-like receptor 2 [KO:K10159]
118013385  TIRAP; toll/interleukin-1 receptor domain-containing adapter protein isoform X1 [KO:K05403]
118001922  MYD88; myeloid differentiation primary response protein MyD88 isoform X1 [KO:K04729]
118016718  CD14; monocyte differentiation antigen CD14 [KO:K04391]
118017761  TLR4; toll-like receptor 4 isoform X1 [KO:K10160]
118014931  LY96; lymphocyte antigen 96 isoform X1 [KO:K05400]
118012989  TLR5; LOW QUALITY PROTEIN: toll-like receptor 5 [KO:K10168]
118004942  toll-like receptor 9 isoform X1 [KO:K10161]
118014698  IRAK1; interleukin-1 receptor-associated kinase 1 isoform X1 [KO:K04730] [EC:2.7.11.1]
118008943  IRAK4; interleukin-1 receptor-associated kinase 4 isoform X1 [KO:K04733] [EC:2.7.11.1]
118015773  TRAF6; TNF receptor-associated factor 6 isoform X1 [KO:K03175] [EC:2.3.2.27]
118001330  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
117998660  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 [KO:K04403]
118001048  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 [KO:K04404]
118007918  TAB3; TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 isoform X1 [KO:K12793]
118014480  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
118024839  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
118009921  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
118002835  NF-kappa-B inhibitor alpha [KO:K04734]
118002880  NF-kappa-B inhibitor alpha [KO:K04734]
118027047  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
118016059  RELA; transcription factor p65 [KO:K04735]
118020927  NOD1; nucleotide-binding oligomerization domain-containing protein 1 isoform X1 [KO:K08727]
118014942  LOW QUALITY PROTEIN: heat shock protein HSP 90-beta-like [KO:K04079]
118001625  HSP90AB1; heat shock protein HSP 90-beta [KO:K04079]
118002022  HSP90AA1; heat shock protein HSP 90-alpha [KO:K04079]
117998807  HSP90B1; endoplasmin [KO:K09487]
118014994  RIPK2; receptor-interacting serine/threonine-protein kinase 2 [KO:K08846] [EC:2.7.11.1]
118023946  CSE1L; exportin-2 [KO:K18423]
118007034  KPNA1; importin subunit alpha-5 [KO:K23940]
118009456  KPNA3; importin subunit alpha-4 [KO:K23583]
118005883  KPNA4; importin subunit alpha-3 isoform X1 [KO:K23583]
118003891  RPS3; 40S ribosomal protein S3 [KO:K02985]
118016228  HRAS; GTPase HRas isoform X1 [KO:K02833]
118005431  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
118003336  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
118004882  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
117999637  MAPK3; mitogen-activated protein kinase 3 isoform X1 [KO:K04371] [EC:2.7.11.24]
117999826  MAPK1; mitogen-activated protein kinase 1 isoform X1 [KO:K04371] [EC:2.7.11.24]
118000167  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 [KO:K04432] [EC:2.7.12.2]
118024329  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 isoform X1 [KO:K04433] [EC:2.7.12.2]
118001095  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
118001265  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
117997742  MAPK11; mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
117997743  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
118000083  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 isoform X1 [KO:K04430] [EC:2.7.12.2]
118005180  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
118022776  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
118010368  mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
118026506  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
118002212  FOS; proto-oncogene c-Fos [KO:K04379]
118019356  JUN; transcription factor AP-1 [KO:K04448]
118027255  TNF; tumor necrosis factor [KO:K03156]
118007867  IL1B; interleukin-1 beta [KO:K04519]
118020856  IL6; interleukin-6 [KO:K05405]
118010458  CXCL8; interleukin-8 [KO:K10030]
118002288  CTNNB1; catenin beta-1 [KO:K02105]
118016638  TCF7; transcription factor 7 isoform X1 [KO:K02620]
118007920  TCF7L1; transcription factor 7-like 1 isoform X1 [KO:K04490]
118026323  TCF7L2; transcription factor 7-like 2 isoform X1 [KO:K04491]
118027079  LEF1; lymphoid enhancer-binding factor 1 isoform X1 [KO:K04492]
118015212  MYC; myc proto-oncogene protein [KO:K04377]
118005930  PKN1; serine/threonine-protein kinase N1 isoform X1 [KO:K06071] [EC:2.7.11.13]
118002928  FBXO22; F-box only protein 22 [KO:K10302]
118016639  SKP1; S-phase kinase-associated protein 1 [KO:K03094]
118025746  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A isoform X1 [KO:K03158]
118017503  TRAF2; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
118023691  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein isoform X1 [KO:K03171]
118013143  BIRC3; baculoviral IAP repeat-containing protein 3 isoform X1 [KO:K16060]
118013146  BIRC2; baculoviral IAP repeat-containing protein 2 isoform X1 [KO:K16060]
118027395  RIPK1; receptor-interacting serine/threonine-protein kinase 1 isoform X1 [KO:K02861] [EC:2.7.11.1]
118025410  glyceraldehyde-3-phosphate dehydrogenase-like [KO:K00134] [EC:1.2.1.12]
118025740  GAPDH; glyceraldehyde-3-phosphate dehydrogenase [KO:K00134] [EC:1.2.1.12]
118026621  glyceraldehyde-3-phosphate dehydrogenase-like [KO:K00134] [EC:1.2.1.12]
118019980  glyceraldehyde-3-phosphate dehydrogenase-like isoform X1 [KO:K00134] [EC:1.2.1.12]
118006404  TNFSF10; tumor necrosis factor ligand superfamily member 10 [KO:K04721]
118016168  FADD; FAS-associated death domain protein [KO:K02373]
118012152  CASP8; caspase-8 isoform X1 [KO:K04398] [EC:3.4.22.61]
118003694  RIPK3; receptor-interacting serine/threonine-protein kinase 3 [KO:K08847] [EC:2.7.11.1]
117998245  BAX; apoptosis regulator BAX isoform X1 [KO:K02159]
118000738  BAK1; bcl-2 homologous antagonist/killer isoform X1 [KO:K14021]
118012283  cytochrome c, testis-specific [KO:K08738]
118019630  cytochrome c-like [KO:K08738]
118020883  cytochrome c [KO:K08738]
118004389  BCL2; apoptosis regulator Bcl-2 isoform X1 [KO:K02161]
118010074  CASP3; caspase-3 isoform X1 [KO:K02187] [EC:3.4.22.56]
118026509  CASP7; caspase-7 isoform X1 [KO:K04397] [EC:3.4.22.60]
118007629  RHOB; rho-related GTP-binding protein RhoB [KO:K07856]
118010591  RHOH; rho-related GTP-binding protein RhoH [KO:K07873]
117998347  RRAS; ras-related protein R-Ras [KO:K07829]
118022658  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
118002024  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
118014553  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
118017830  TXN; thioredoxin isoform X1 [KO:K03671]
117997460  thioredoxin-like [KO:K03671]
117998734  TXN2; thioredoxin, mitochondrial [KO:K03671]
118014138  thioredoxin-like isoform X1 [KO:K03671]
118026897  NLRP3; NACHT, LRR and PYD domains-containing protein 3 isoform X1 [KO:K12800]
118007513  NLRC4; LOW QUALITY PROTEIN: NLR family CARD domain-containing protein 4 [KO:K12805]
117999561  apoptosis-associated speck-like protein containing a CARD isoform X1 [KO:K12799]
118013235  IL18; interleukin-18 isoform X1 [KO:K05482]
118013165  caspase-13-like isoform X1 [KO:K04394] [EC:3.4.22.57 3.4.22.64]
118015271  GSDMD; gasdermin-D isoform X1 [KO:K20917]
Compound
C00338  Lipopolysaccharide
C01194  1-Phosphatidyl-D-myo-inositol
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11554  1-Phosphatidyl-1D-myo-inositol 3,4-bisphosphate
Reference
PMID:28875943
  Authors
Bernal-Bayard J, Ramos-Morales F
  Title
Molecular Mechanisms Used by Salmonella to Evade the Immune System.
  Journal
Curr Issues Mol Biol 25:133-168 (2018)
DOI:10.21775/cimb.025.133
Reference
PMID:28848711
  Authors
Hume PJ, Singh V, Davidson AC, Koronakis V
  Title
Swiss Army Pathogen: The Salmonella Entry Toolkit.
  Journal
Front Cell Infect Microbiol 7:348 (2017)
DOI:10.3389/fcimb.2017.00348
Reference
PMID:31402916
  Authors
Wemyss MA, Pearson JS
  Title
Host Cell Death Responses to Non-typhoidal Salmonella Infection.
  Journal
Front Immunol 10:1758 (2019)
DOI:10.3389/fimmu.2019.01758
Reference
PMID:27974148
  Authors
Bierschenk D, Boucher D, Schroder K
  Title
Salmonella-induced inflammasome activation in humans.
  Journal
Mol Immunol 86:38-43 (2017)
DOI:10.1016/j.molimm.2016.11.009
Reference
PMID:29477730
  Authors
Pinaud L, Sansonetti PJ, Phalipon A
  Title
Host Cell Targeting by Enteropathogenic Bacteria T3SS Effectors.
  Journal
Trends Microbiol 26:266-283 (2018)
DOI:10.1016/j.tim.2018.01.010
Reference
PMID:25749450
  Authors
LaRock DL, Chaudhary A, Miller SI
  Title
Salmonellae interactions with host processes.
  Journal
Nat Rev Microbiol 13:191-205 (2015)
DOI:10.1038/nrmicro3420
Reference
PMID:17983751
  Authors
Ramsden AE, Holden DW, Mota LJ
  Title
Membrane dynamics and spatial distribution of Salmonella-containing vacuoles.
  Journal
Trends Microbiol 15:516-24 (2007)
DOI:10.1016/j.tim.2007.10.002
Reference
PMID:22702524
  Authors
van der Heijden J, Finlay BB
  Title
Type III effector-mediated processes in Salmonella infection.
  Journal
Future Microbiol 7:685-703 (2012)
DOI:10.2217/fmb.12.49
Reference
PMID:27222578
  Authors
Galan JE
  Title
Typhoid toxin provides a window into typhoid fever and the biology of Salmonella Typhi.
  Journal
Proc Natl Acad Sci U S A 113:6338-44 (2016)
DOI:10.1073/pnas.1606335113
Reference
PMID:19157959
  Authors
McGhie EJ, Brawn LC, Hume PJ, Humphreys D, Koronakis V
  Title
Salmonella takes control: effector-driven manipulation of the host.
  Journal
Curr Opin Microbiol 12:117-24 (2009)
DOI:10.1016/j.mib.2008.12.001
Reference
PMID:12675800
  Authors
Miao EA, Brittnacher M, Haraga A, Jeng RL, Welch MD, Miller SI
  Title
Salmonella effectors translocated across the vacuolar membrane interact with the actin cytoskeleton.
  Journal
Mol Microbiol 48:401-15 (2003)
DOI:10.1046/j.1365-2958.2003.t01-1-03456.x
Reference
PMID:17074883
  Authors
Patel JC, Galan JE
  Title
Differential activation and function of Rho GTPases during Salmonella-host cell interactions.
  Journal
J Cell Biol 175:453-63 (2006)
DOI:10.1083/jcb.200605144
Reference
PMID:18411289
  Authors
Wasylnka JA, Bakowski MA, Szeto J, Ohlson MB, Trimble WS, Miller SI, Brumell JH
  Title
Role for myosin II in regulating positioning of Salmonella-containing vacuoles and intracellular replication.
  Journal
Infect Immun 76:2722-35 (2008)
DOI:10.1128/IAI.00152-08
Reference
PMID:10499590
  Authors
Fu Y, Galan JE
  Title
A salmonella protein antagonizes Rac-1 and Cdc42 to mediate host-cell recovery after bacterial invasion.
  Journal
Nature 401:293-7 (1999)
DOI:10.1038/45829
Related
pathway
mlx04010  MAPK signaling pathway
mlx04064  NF-kappa B signaling pathway
mlx04210  Apoptosis
mlx04217  Necroptosis
mlx04621  NOD-like receptor signaling pathway
KO pathway
ko05132   
LinkDB

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