Entry
Name
Salmonella infection - Miniopterus natalensis (Natal long-fingered bat)
Description
Salmonella infection usually presents as a self-limiting gastroenteritis or the more severe typhoid fever and bacteremia. The common disease-causing Salmonella species in human is a single species, Salmonella enterica, which has numerous serovars.
Following intestinal colonization Salmonella inject effector proteins into the host cells using a type III secretion system (T3SS), T3SS1. Then a small group of effector proteins induce rearrangement of the actin cytoskeleton resulting in membrane ruffles and rapid internalization of the bacteria.The T3SS2 is responsible for translocating effector proteins that direct Salmonella-containing vacuole (SCV) maturation. The majority of the bacteria are known to survive and replicate in SCV.
Class
Human Diseases; Infectious disease: bacterial
BRITE hierarchy
Pathway map
Ortholog table
Organism
Miniopterus natalensis (Natal long-fingered bat) [GN:
mna ]
Gene
107528875 PLEKHM1; pleckstrin homology domain-containing family M member 1 isoform X1 [KO:K23282 ]
107533099 VPS11; vacuolar protein sorting-associated protein 11 homolog [KO:K20179 ]
107539345 VPS16; vacuolar protein sorting-associated protein 16 homolog isoform X1 [KO:K20180 ]
107543028 VPS18; vacuolar protein sorting-associated protein 18 homolog [KO:K20181 ]
107541855 VPS33A; vacuolar protein sorting-associated protein 33A [KO:K20182 ]
107526627 VPS41; vacuolar protein sorting-associated protein 41 homolog isoform X1 [KO:K20184 ]
107535645 RILP; LOW QUALITY PROTEIN: rab-interacting lysosomal protein [KO:K13883 ]
107536492 DYNC1H1; cytoplasmic dynein 1 heavy chain 1 isoform X1 [KO:K10413 ]
107532412 DYNC2H1; cytoplasmic dynein 2 heavy chain 1 isoform X1 [KO:K10414 ]
107541728 DYNC1I1; cytoplasmic dynein 1 intermediate chain 1 isoform X1 [KO:K10415 ]
107530249 DYNC1I2; cytoplasmic dynein 1 intermediate chain 2 isoform X1 [KO:K10415 ]
107526387 DYNC1LI1; cytoplasmic dynein 1 light intermediate chain 1 [KO:K10416 ]
107537214 DYNC1LI2; cytoplasmic dynein 1 light intermediate chain 2 isoform X1 [KO:K10416 ]
107530351 DYNC2LI1; cytoplasmic dynein 2 light intermediate chain 1 isoform X1 [KO:K10417 ]
107529402 FYCO1; FYVE and coiled-coil domain-containing protein 1 [KO:K21954 ]
107531570 PLEKHM2; pleckstrin homology domain-containing family M member 2 [KO:K15348 ]
107544047 M6PR; cation-dependent mannose-6-phosphate receptor isoform X1 [KO:K10089 ]
107528708 GCC2; GRIP and coiled-coil domain-containing protein 2 [KO:K20282 ]
107543099 AHNAK; neuroblast differentiation-associated protein AHNAK [KO:K23934 ]
107530890 ELMO2; engulfment and cell motility protein 2 isoform X1 [KO:K18985 ]
107529566 MYL2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351 ]
107542067 MYL7; myosin regulatory light chain 2, atrial isoform [KO:K12754 ]
107526566 MYL10; LOW QUALITY PROTEIN: myosin regulatory light chain 10 [KO:K12756 ]
107541481 MYLPF; myosin regulatory light chain 2, skeletal muscle isoform [KO:K12758 ]
107537346 FHOD1; LOW QUALITY PROTEIN: FH1/FH2 domain-containing protein 1 [KO:K23938 ]
107538414 CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393 ]
107537599 RAC1; LOW QUALITY PROTEIN: ras-related C3 botulinum toxin substrate 1 [KO:K04392 ]
107546408 WASF3; wiskott-Aldrich syndrome protein family member 3 [KO:K06083 ]
107540948 ARPC1A; actin-related protein 2/3 complex subunit 1A isoform X1 [KO:K05757 ]
107524752 ARPC2; actin-related protein 2/3 complex subunit 2 isoform X1 [KO:K05758 ]
107535481 ARPC5L; actin-related protein 2/3 complex subunit 5-like protein [KO:K05754 ]
107532628 PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922 ] [EC:2.7.1.153 ]
107538463 PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922 ] [EC:2.7.1.153 ]
107541106 PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922 ] [EC:2.7.1.153 ]
107530834 PIK3CG; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform [KO:K21289 ] [EC:2.7.1.153 ]
107539064 PIK3C2B; phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta [KO:K00923 ] [EC:2.7.1.154 ]
107525348 PIK3C2G; phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma isoform X1 [KO:K00923 ] [EC:2.7.1.154 ]
107546701 PIK3C2A; phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha isoform X1 [KO:K00923 ] [EC:2.7.1.154 ]
107530599 TIRAP; toll/interleukin-1 receptor domain-containing adapter protein [KO:K05403 ]
107524328 MYD88; myeloid differentiation primary response protein MyD88 [KO:K04729 ]
107531263 TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform X1 [KO:K04403 ]
107545742 TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 [KO:K04404 ]
107534451 TAB3; TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 isoform X1 [KO:K12793 ]
107545508 NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580 ]
107544418 NOD1; nucleotide-binding oligomerization domain-containing protein 1 [KO:K08727 ]
107544039 TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158 ]
107537536 TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171 ]
107533523 TNFSF10; tumor necrosis factor ligand superfamily member 10 [KO:K04721 ]
107540363 tumor necrosis factor receptor superfamily member 1A-like isoform X1 [KO:K04722 ]
107536102 tumor necrosis factor receptor superfamily member 10A-like [KO:K04722 ]
107529863 NLRP3; NACHT, LRR and PYD domains-containing protein 3 [KO:K12800 ]
107541770 NLRC4; NLR family CARD domain-containing protein 4 isoform X1 [KO:K12805 ]
107540813 PYCARD; apoptosis-associated speck-like protein containing a CARD isoform X1 [KO:K12799 ]
Compound
C01194 1-Phosphatidyl-D-myo-inositol
C04549 1-Phosphatidyl-1D-myo-inositol 3-phosphate
C05981 Phosphatidylinositol-3,4,5-trisphosphate
C11554 1-Phosphatidyl-1D-myo-inositol 3,4-bisphosphate
Reference
Authors
Bernal-Bayard J, Ramos-Morales F
Title
Molecular Mechanisms Used by Salmonella to Evade the Immune System.
Journal
Reference
Authors
Hume PJ, Singh V, Davidson AC, Koronakis V
Title
Swiss Army Pathogen: The Salmonella Entry Toolkit.
Journal
Reference
Authors
Wemyss MA, Pearson JS
Title
Host Cell Death Responses to Non-typhoidal Salmonella Infection.
Journal
Reference
Authors
Bierschenk D, Boucher D, Schroder K
Title
Salmonella-induced inflammasome activation in humans.
Journal
Reference
Authors
Pinaud L, Sansonetti PJ, Phalipon A
Title
Host Cell Targeting by Enteropathogenic Bacteria T3SS Effectors.
Journal
Reference
Authors
LaRock DL, Chaudhary A, Miller SI
Title
Salmonellae interactions with host processes.
Journal
Reference
Authors
Ramsden AE, Holden DW, Mota LJ
Title
Membrane dynamics and spatial distribution of Salmonella-containing vacuoles.
Journal
Reference
Authors
van der Heijden J, Finlay BB
Title
Type III effector-mediated processes in Salmonella infection.
Journal
Reference
Authors
Galan JE
Title
Typhoid toxin provides a window into typhoid fever and the biology of Salmonella Typhi.
Journal
Reference
Authors
McGhie EJ, Brawn LC, Hume PJ, Humphreys D, Koronakis V
Title
Salmonella takes control: effector-driven manipulation of the host.
Journal
Reference
Authors
Miao EA, Brittnacher M, Haraga A, Jeng RL, Welch MD, Miller SI
Title
Salmonella effectors translocated across the vacuolar membrane interact with the actin cytoskeleton.
Journal
Reference
Authors
Patel JC, Galan JE
Title
Differential activation and function of Rho GTPases during Salmonella-host cell interactions.
Journal
Reference
Authors
Wasylnka JA, Bakowski MA, Szeto J, Ohlson MB, Trimble WS, Miller SI, Brumell JH
Title
Role for myosin II in regulating positioning of Salmonella-containing vacuoles and intracellular replication.
Journal
Reference
Authors
Fu Y, Galan JE
Title
A salmonella protein antagonizes Rac-1 and Cdc42 to mediate host-cell recovery after bacterial invasion.
Journal
Related pathway
mna04621 NOD-like receptor signaling pathway
KO pathway
LinkDB
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