KEGG   PATHWAY: nsu05167
Entry
nsu05167                    Pathway                                
Name
Kaposi sarcoma-associated herpesvirus infection - Neomonachus schauinslandi (Hawaiian monk seal)
Description
Kaposi sarcoma-associated herpesvirus (KSHV), also known as human herpesvirus 8 (HHV-8), is the most recently identified human tumor virus, and is associated with the pathogenesis of Kaposi's sarcoma (KS), primary effusion lymphoma (PEL), and Multicentric Castleman's disease (MCD). Like all other herpesviruses, KSHV displays two modes of life cycle, latency and lytic replication, which are characterized by the patterns of viral gene expression. Genes expressed in latency (LANA, v-cyclin, v-FLIP, Kaposins A, B and C and viral miRNAs) are mainly thought to facilitate the establishment of life long latency in its host and survival against the host innate, and adaptive immune surveillance mechanisms. Among the viral proteins shown to be expressed during lytic replication are potent signaling molecules such as vGPCR, vIL6, vIRFs, vCCLs, K1 and K15, which have been implicated experimentally in the angiogenic and inflammatory phenotype observed in KS lesions. Several of these latent viral and lytic proteins are known to transform host cells, linking KSHV with the development of severe human malignancies.
Class
Human Diseases; Infectious disease: viral
Pathway map
nsu05167  Kaposi sarcoma-associated herpesvirus infection
nsu05167

Organism
Neomonachus schauinslandi (Hawaiian monk seal) [GN:nsu]
Gene
110593993  C3; complement C3 [KO:K03990]
110584213  TLR3; toll-like receptor 3 [KO:K05401]
110593848  TICAM1; TIR domain-containing adapter molecule 1 isoform X1 [KO:K05842]
110571685  TRAF3; TNF receptor-associated factor 3 isoform X1 [KO:K03174]
110577285  IKBKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X1 [KO:K07211] [EC:2.7.11.10]
110570585  TBK1; serine/threonine-protein kinase TBK1 isoform X2 [KO:K05410] [EC:2.7.11.10]
110582214  IRF7; interferon regulatory factor 7 [KO:K09447]
123326492  interferon alpha-1/2-like [KO:K05414]
123326498  interferon alpha-like [KO:K05414]
110587126  LOW QUALITY PROTEIN: interferon alpha [KO:K05414]
110587131  interferon alpha-16-like [KO:K05414]
110572882  IRF3; interferon regulatory factor 3 isoform X1 [KO:K05411]
110588014  CREB-binding protein isoform X2 [KO:K04498] [EC:2.3.1.48]
110577947  EP300; LOW QUALITY PROTEIN: histone acetyltransferase p300 [KO:K04498] [EC:2.3.1.48]
110587130  IFNB1; interferon beta [KO:K05415]
110570024  IFNAR1; interferon alpha/beta receptor 1 isoform X1 [KO:K05130]
110570027  IFNAR2; interferon alpha/beta receptor 2 isoform X1 [KO:K05131]
110571840  JAK1; tyrosine-protein kinase JAK1 isoform X1 [KO:K11217] [EC:2.7.10.2]
110593684  TYK2; non-receptor tyrosine-protein kinase TYK2 isoform X3 [KO:K11219] [EC:2.7.10.2]
110592138  STAT1; signal transducer and activator of transcription 1-alpha/beta isoform X1 [KO:K11220]
110577818  STAT2; signal transducer and activator of transcription 2 isoform X1 [KO:K11221]
110585591  IRF9; interferon regulatory factor 9 isoform X1 [KO:K04693]
110587259  EIF2AK2; interferon-induced, double-stranded RNA-activated protein kinase [KO:K16195] [EC:2.7.11.1]
110575614  MAPK13; mitogen-activated protein kinase 13 isoform X1 [KO:K04441] [EC:2.7.11.24]
110575674  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
110578302  MAPK12; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
110578303  MAPK11; mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
110574092  MAPKAPK2; MAP kinase-activated protein kinase 2 isoform X1 [KO:K04443] [EC:2.7.11.1]
110570428  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 [KO:K04433] [EC:2.7.12.2]
110590263  ZFP36; mRNA decay activator protein ZFP36 [KO:K15308]
110580018  IL6; interleukin-6 isoform X1 [KO:K05405]
110591203  CSF2; granulocyte-macrophage colony-stimulating factor [KO:K05427]
110574373  CCR3; C-C chemokine receptor type 3 [KO:K04178]
110574370  C-C chemokine receptor type 5 [KO:K04180]
110574374  C-C chemokine receptor type 1-like [KO:K04176]
110569621  CCR4; C-C chemokine receptor type 4 [KO:K04179]
110594319  CCR8; C-C chemokine receptor type 8 [KO:K04183]
110585971  FAS; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
110576065  FADD; FAS-associated death domain protein [KO:K02373]
110592166  CASP8; caspase-8 [KO:K04398] [EC:3.4.22.61]
110580739  BID; BH3-interacting domain death agonist isoform X1 [KO:K04726]
110572854  BAX; apoptosis regulator BAX isoform X3 [KO:K02159]
110575593  BAK1; bcl-2 homologous antagonist/killer [KO:K14021]
110579961  cytochrome c [KO:K08738]
110575385  cytochrome c-like [KO:K08738]
110592054  cytochrome c, testis-specific [KO:K08738]
110594255  cytochrome c-like [KO:K08738]
110574689  CASP9; caspase-9 isoform X2 [KO:K04399] [EC:3.4.22.62]
110584089  CASP3; caspase-3 isoform X1 [KO:K02187] [EC:3.4.22.56]
110580878  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
110592808  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein isoform X1 [KO:K03171]
110581233  TRAF2; TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
110589216  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
110573165  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
110574194  IKBKG; NF-kappa-B essential modulator [KO:K07210]
110585142  NFKBIA; NF-kappa-B inhibitor alpha isoform X2 [KO:K04734]
110572155  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
110575986  RELA; transcription factor p65 [KO:K04735]
110584444  TP53; cellular tumor antigen p53 [KO:K04451]
110575681  CDKN1A; cyclin-dependent kinase inhibitor 1 isoform X2 [KO:K06625]
110577858  CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
110579972  CDK6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
110579773  RB1; retinoblastoma-associated protein [KO:K06618]
110579642  E2F1; LOW QUALITY PROTEIN: transcription factor E2F1 [KO:K17454]
110574749  E2F2; transcription factor E2F2 [KO:K09389]
110586656  E2F3; transcription factor E2F3 isoform X1 [KO:K06620]
110580263  H-2 class I histocompatibility antigen, Q10 alpha chain-like isoform X1 [KO:K06751]
110575688  class I histocompatibility antigen, Gogo-C*0202 alpha chain-like [KO:K06751]
110586919  LOW QUALITY PROTEIN: HLA class I histocompatibility antigen, A alpha chain [KO:K06751]
110581264  LOW QUALITY PROTEIN: patr class I histocompatibility antigen, A-126 alpha chain-like [KO:K06751]
110583311  IFNGR1; LOW QUALITY PROTEIN: interferon gamma receptor 1 [KO:K05132]
110593812  ICAM1; intercellular adhesion molecule 1 [KO:K06490]
110582431  CD86; T-lymphocyte activation antigen CD86 [KO:K05413]
110580777  CLEC2B; C-type lectin domain family 2 member B [KO:K10071]
123324321  ubiquitin-60S ribosomal protein L40-like [KO:K02927]
110574551  UBA52; ubiquitin-60S ribosomal protein L40 [KO:K02927]
110586377  ubiquitin-60S ribosomal protein L40-like [KO:K02927]
110572605  LOW QUALITY PROTEIN: ubiquitin-like [KO:K02927]
110591344  ubiquitin-40S ribosomal protein S27a-like [KO:K02977]
110588689  ubiquitin-40S ribosomal protein S27a-like [KO:K02977]
110587656  ubiquitin-40S ribosomal protein S27a-like [KO:K02977]
110585897  ubiquitin-40S ribosomal protein S27a-like [KO:K02977]
110590489  RPS27A; ubiquitin-40S ribosomal protein S27a [KO:K02977]
110590956  ubiquitin-40S ribosomal protein S27a-like [KO:K02977]
110576280  ubiquitin-40S ribosomal protein S27a-like [KO:K02977]
123325286  UBB; polyubiquitin-B [KO:K04551]
110574233  BECN2; beclin-2 [KO:K08334]
110573215  BECN1; beclin-1 isoform X1 [KO:K08334]
110590665  ATG14; beclin 1-associated autophagy-related key regulator [KO:K17889]
110577075  PIK3C3; phosphatidylinositol 3-kinase catalytic subunit type 3 [KO:K00914] [EC:2.7.1.137]
110582456  ATG3; ubiquitin-like-conjugating enzyme ATG3 isoform X1 [KO:K08343]
110574234  MAP1LC3C; microtubule-associated proteins 1A/1B light chain 3C [KO:K10435]
110590011  microtubule-associated proteins 1A/1B light chain 3B-like [KO:K10435]
110594190  MAP1LC3B; microtubule-associated proteins 1A/1B light chain 3B isoform X1 [KO:K10435]
110579399  MAP1LC3A; microtubule-associated proteins 1A/1B light chain 3A [KO:K10435]
110575102  GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
110571879  GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
110581074  GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 [KO:K07825]
110582429  GNB4; guanine nucleotide-binding protein subunit beta-4 [KO:K04538]
110583964  GNB5; guanine nucleotide-binding protein subunit beta-5 [KO:K04539]
110590624  GNG2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 [KO:K07826]
110575905  GNG3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
110586041  GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
110590844  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5-like [KO:K04542]
110580660  GNG5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
110575312  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5-like [KO:K04542]
110593950  GNG7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543]
110572795  GNG8; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 [KO:K04544]
110588574  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10-like [KO:K04545]
110581444  GNG10; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
110582181  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10-like [KO:K04545]
110580003  GNG11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
110583870  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11-like [KO:K04546]
110587626  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12-like [KO:K04347]
110588681  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12-like [KO:K04347]
110571845  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
110588033  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547]
123323680  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547]
110579839  GNGT1; guanine nucleotide-binding protein G(T) subunit gamma-T1 [KO:K04548]
110592985  GNGT2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 isoform X1 [KO:K04549]
110582206  HRAS; GTPase HRas isoform X1 [KO:K02833]
123323805  GTPase HRas-like [KO:K02833]
110580861  KRAS; GTPase KRas isoform X1 [KO:K07827]
110580342  NRAS; GTPase NRas [KO:K07828]
110584928  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X2 [KO:K04366] [EC:2.7.11.1]
110584045  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
110593734  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
110589825  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
110578336  MAPK1; mitogen-activated protein kinase 1 isoform X1 [KO:K04371] [EC:2.7.11.24]
110590734  HIF1A; hypoxia-inducible factor 1-alpha isoform X1 [KO:K08268]
110575086  JUN; transcription factor AP-1 isoform X1 [KO:K04448]
110571456  FOS; proto-oncogene c-Fos [KO:K04379]
110574259  PIK3CG; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform [KO:K21289] [EC:2.7.1.153]
110584628  PIK3R5; phosphoinositide 3-kinase regulatory subunit 5 isoform X1 [KO:K21290]
110584669  PIK3R6; LOW QUALITY PROTEIN: phosphoinositide 3-kinase regulatory subunit 6 [KO:K21290]
110575119  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
110582352  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
110570825  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
110574558  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta isoform X1 [KO:K02649]
110575009  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
110591287  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
110574156  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
110590250  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
110571694  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
110575132  MTOR; serine/threonine-protein kinase mTOR isoform X1 [KO:K07203] [EC:2.7.11.1]
110576706  PREX1; phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein [KO:K12365]
110572663  LOW QUALITY PROTEIN: ras-related C3 botulinum toxin substrate 1-like [KO:K04392]
110571993  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
110591392  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
110589690  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
110580283  MAPK9; LOW QUALITY PROTEIN: mitogen-activated protein kinase 9 [KO:K04440] [EC:2.7.11.24]
110579002  cell surface glycoprotein CD200 receptor 2-like [KO:K21668]
110582567  cell surface glycoprotein CD200 receptor 1-like [KO:K21668]
110584304  SYK; tyrosine-protein kinase SYK [KO:K05855] [EC:2.7.10.2]
110579592  SRC; proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
110579337  HCK; tyrosine-protein kinase HCK isoform X1 [KO:K08893] [EC:2.7.10.2]
110579039  LYN; tyrosine-protein kinase Lyn isoform X1 [KO:K05854] [EC:2.7.10.2]
110584510  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 isoform X2 [KO:K04430] [EC:2.7.12.2]
110593849  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
110593864  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
110579324  PLCG1; LOW QUALITY PROTEIN: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 [KO:K01116] [EC:3.1.4.11]
110584934  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
110580957  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
110575641  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 isoform X1 [KO:K04960]
110592076  calmodulin-1-like [KO:K02183]
110592156  calmodulin-like [KO:K02183]
110575336  CALML6; calmodulin-like protein 6 [KO:K02183]
110580773  calmodulin-A-like [KO:K02183]
110590483  CALM2; calmodulin-2 isoform X1 [KO:K02183]
110583920  CALML4; LOW QUALITY PROTEIN: calmodulin-like protein 4 [KO:K02183]
110592210  calmodulin-1-like [KO:K02183]
110571658  CALM1; calmodulin-1 [KO:K02183]
110586535  CALML5; calmodulin-like protein 5 [KO:K02183]
110586587  calmodulin-like protein 3 [KO:K02183]
110572919  CALM3; calmodulin-3 [KO:K02183]
110572137  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
110588665  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
110589703  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
110588763  PPP3R1; calcineurin subunit B type 1 [KO:K06268]
110581497  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
110576910  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
110576691  NFATC2; nuclear factor of activated T-cells, cytoplasmic 2 [KO:K17332]
110594240  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
110585196  NFATC4; nuclear factor of activated T-cells, cytoplasmic 4 isoform X1 [KO:K17334]
110591342  CXCL8; interleukin-8 [KO:K10030]
110573976  PTGS2; prostaglandin G/H synthase 2 [KO:K11987] [EC:1.14.99.1]
110591461  growth-regulated protein homolog gamma-like [KO:K05505]
110591463  growth-regulated protein homolog beta-like [KO:K05505]
110591473  growth-regulated protein homolog beta-like [KO:K05505]
110570107  RCAN1; calcipressin-1 isoform X1 [KO:K17901]
110573062  FGF2; LOW QUALITY PROTEIN: fibroblast growth factor 2 [KO:K18497]
110581991  VEGFA; vascular endothelial growth factor A isoform X1 [KO:K05448]
110578163  PDGFB; platelet-derived growth factor subunit B isoform X1 [KO:K17386]
110584268  ANGPT2; angiopoietin-2 isoform X1 [KO:K05466]
110590912  IL6ST; interleukin-6 receptor subunit beta isoform X1 [KO:K05060]
110584421  JAK2; tyrosine-protein kinase JAK2 isoform X1 [KO:K04447] [EC:2.7.10.2]
110573316  STAT3; signal transducer and activator of transcription 3 isoform X5 [KO:K04692]
110582720  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
110569652  CTNNB1; catenin beta-1 [KO:K02105]
110590995  TCF7; transcription factor 7 isoform X1 [KO:K02620]
110587588  TCF7L1; transcription factor 7-like 1 [KO:K04490]
110589494  TCF7L2; transcription factor 7-like 2 isoform X1 [KO:K04491]
110575521  LEF1; lymphoid enhancer-binding factor 1 isoform X1 [KO:K04492]
110592296  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X2 [KO:K05870]
110576391  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
110578930  MYC; myc proto-oncogene protein [KO:K04377]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00350  Phosphatidylethanolamine
C01245  D-myo-Inositol 1,4,5-trisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:22403573
  Authors
Lee HR, Brulois K, Wong L, Jung JU
  Title
Modulation of Immune System by Kaposi's Sarcoma-Associated Herpesvirus: Lessons from Viral Evasion Strategies.
  Journal
Front Microbiol 3:44 (2012)
DOI:10.3389/fmicb.2012.00044
Reference
PMID:18948197
  Authors
Liang C, Lee JS, Jung JU
  Title
Immune evasion in Kaposi's sarcoma-associated herpes virus associated oncogenesis.
  Journal
Semin Cancer Biol 18:423-36 (2008)
DOI:10.1016/j.semcancer.2008.09.003
Reference
PMID:21040832
  Authors
Cai Q, Verma SC, Lu J, Robertson ES
  Title
Molecular biology of Kaposi's sarcoma-associated herpesvirus and related oncogenesis.
  Journal
Adv Virus Res 78:87-142 (2010)
DOI:10.1016/B978-0-12-385032-4.00003-3
Reference
PMID:16760382
  Authors
Rezaee SA, Cunningham C, Davison AJ, Blackbourn DJ
  Title
Kaposi's sarcoma-associated herpesvirus immune modulation: an overview.
  Journal
J Gen Virol 87:1781-804 (2006)
DOI:10.1099/vir.0.81919-0
Reference
PMID:19230674
  Authors
Areste C, Blackbourn DJ
  Title
Modulation of the immune system by Kaposi's sarcoma-associated herpesvirus.
  Journal
Trends Microbiol 17:119-29 (2009)
DOI:10.1016/j.tim.2008.12.001
Reference
PMID:16905191
  Authors
Mark L, Spiller OB, Villoutreix BO, Blom AM
  Title
Kaposi's sarcoma-associated herpes virus complement control protein: KCP--complement inhibition and more.
  Journal
Mol Immunol 44:11-22 (2007)
DOI:10.1016/j.molimm.2006.06.018
Reference
PMID:11500830
  Authors
Weber KS, Grone HJ, Rocken M, Klier C, Gu S, Wank R, Proudfoot AE, Nelson PJ, Weber C
  Title
Selective recruitment of Th2-type cells and evasion from a cytotoxic immune response mediated by viral macrophage inhibitory protein-II.
  Journal
Eur J Immunol 31:2458-66 (2001)
DOI:10.1002/1521-4141(200108)31:8<2458::AID-IMMU2458>3.0.CO;2-L
Reference
PMID:10666184
  Authors
Stine JT, Wood C, Hill M, Epp A, Raport CJ, Schweickart VL, Endo Y, Sasaki T, Simmons G, Boshoff C, Clapham P, Chang Y, Moore P, Gray PW, Chantry D
  Title
KSHV-encoded CC chemokine vMIP-III is a CCR4 agonist, stimulates angiogenesis, and selectively chemoattracts TH2 cells.
  Journal
Blood 95:1151-7 (2000)
Reference
PMID:26431609
  Authors
Schulz TF, Cesarman E
  Title
Kaposi Sarcoma-associated Herpesvirus: mechanisms of oncogenesis.
  Journal
Curr Opin Virol 14:116-28 (2015)
DOI:10.1016/j.coviro.2015.08.016
Reference
PMID:10377196
  Authors
Endres MJ, Garlisi CG, Xiao H, Shan L, Hedrick JA
  Title
The Kaposi's sarcoma-related herpesvirus (KSHV)-encoded chemokine vMIP-I is a specific agonist for the CC chemokine receptor (CCR)8.
  Journal
J Exp Med 189:1993-8 (1999)
DOI:10.1084/jem.189.12.1993
Reference
PMID:18434408
  Authors
Choi YB, Nicholas J
  Title
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J Virol 82:6501-13 (2008)
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The kaposin B protein of KSHV activates the p38/MK2 pathway and stabilizes cytokine mRNAs.
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Science 307:739-41 (2005)
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Trends Mol Med 11:309-12 (2005)
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Biochim Biophys Acta 1766:140-58 (2006)
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Characterization of an anti-apoptotic glycoprotein encoded by Kaposi's sarcoma-associated herpesvirus which resembles a spliced variant of human survivin.
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EMBO J 21:2602-15 (2002)
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The inhibitor of death receptor signaling, FLICE-inhibitory protein defines a new class of tumor progression factors.
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J Exp Med 190:1025-32 (1999)
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Oncogene 18:5738-46 (1999)
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KSHV vFLIP binds to IKK-gamma to activate IKK.
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J Cell Sci 116:3721-8 (2003)
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Nat Rev Cancer 10:707-19 (2010)
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Downregulation of major histocompatibility complex class I molecules by Kaposi's sarcoma-associated herpesvirus K3 and K5 proteins.
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J Virol 74:5300-9 (2000)
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Downregulation of gamma interferon receptor 1 by Kaposi's sarcoma-associated herpesvirus K3 and K5.
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J Virol 81:2117-27 (2007)
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Down-regulation of NKG2D and NKp80 ligands by Kaposi's sarcoma-associated herpesvirus K5 protects against NK cell cytotoxicity.
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Proc Natl Acad Sci U S A 105:1656-61 (2008)
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A viral protein that selectively downregulates ICAM-1 and B7-2 and modulates T cell costimulation.
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Kaposi's sarcoma-associated herpesvirus: a new human tumor virus, but how?
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Antiviral activity of tumor-suppressor pathways: clues from molecular piracy by KSHV.
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Molecular biology and pathogenesis of Kaposi sarcoma-associated herpesvirus.
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The molecular pathology of Kaposi's sarcoma-associated herpesvirus.
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Biochim Biophys Acta 1602:1-22 (2002)
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Foster-Cuevas M, Wright GJ, Puklavec MJ, Brown MH, Barclay AN
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Human herpesvirus 8 K14 protein mimics CD200 in down-regulating macrophage activation through CD200 receptor.
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J Virol 78:7667-76 (2004)
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Sodhi A, Montaner S, Patel V, Zohar M, Bais C, Mesri EA, Gutkind JS
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The Kaposi's sarcoma-associated herpes virus G protein-coupled receptor up-regulates vascular endothelial growth factor expression and secretion through mitogen-activated protein kinase and p38 pathways acting on hypoxia-inducible factor 1alpha.
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Cancer Res 60:4873-80 (2000)
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KSHV non-structural membrane proteins involved in the activation of intracellular signaling pathways and the pathogenesis of Kaposi's sarcoma.
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Curr Opin Virol 20:11-19 (2016)
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Nat Rev Mol Cell Biol 5:998-1012 (2004)
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Akt/TSC/mTOR activation by the KSHV G protein-coupled receptor: emerging insights into the molecular oncogenesis and treatment of Kaposi's sarcoma.
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Kaposi's sarcoma herpesvirus K15 protein contributes to virus-induced angiogenesis by recruiting PLCgamma1 and activating NFAT1-dependent RCAN1 expression.
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PLoS Pathog 8:e1002927 (2012)
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Lagunoff M, Majeti R, Weiss A, Ganem D
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Deregulated signal transduction by the K1 gene product of Kaposi's sarcoma-associated herpesvirus.
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Biology and oncogenicity of the Kaposi sarcoma herpesvirus K1 protein.
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Rev Med Virol 25:273-85 (2015)
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Havemeier A, Gramolelli S, Pietrek M, Jochmann R, Sturzl M, Schulz TF
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Activation of NF-kappaB by the Kaposi's sarcoma-associated herpesvirus K15 protein involves recruitment of the NF-kappaB-inducing kinase, IkappaB kinases, and phosphorylation of p65.
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J Virol 88:13161-72 (2014)
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Brinkmann MM, Pietrek M, Dittrich-Breiholz O, Kracht M, Schulz TF
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Modulation of host gene expression by the K15 protein of Kaposi's sarcoma-associated herpesvirus.
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J Virol 81:42-58 (2007)
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Wang L, Dittmer DP, Tomlinson CC, Fakhari FD, Damania B
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Immortalization of primary endothelial cells by the K1 protein of Kaposi's sarcoma-associated herpesvirus.
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Cancer Res 66:3658-66 (2006)
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Morris VA, Punjabi AS, Wells RC, Wittkopp CJ, Vart R, Lagunoff M
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The KSHV viral IL-6 homolog is sufficient to induce blood to lymphatic endothelial cell differentiation.
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Virology 428:112-20 (2012)
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Purushothaman P, Uppal T, Verma SC
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Molecular biology of KSHV lytic reactivation.
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Viruses 7:116-53 (2015)
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Fujimuro M, Hayward SD
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Manipulation of glycogen-synthase kinase-3 activity in KSHV-associated cancers.
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J Mol Med (Berl) 82:223-31 (2004)
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PMID:26870016
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Purushothaman P, Dabral P, Gupta N, Sarkar R, Verma SC
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KSHV Genome Replication and Maintenance.
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Front Microbiol 7:54 (2016)
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pathway
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nsu04144  Endocytosis
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KO pathway
ko05167   
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