KEGG   PATHWAY: oor04062
Entry
oor04062                    Pathway                                
Name
Chemokine signaling pathway - Orcinus orca (killer whale)
Description
Inflammatory immune response requires the recruitment of leukocytes to the site of inflammation upon foreign insult. Chemokines are small chemoattractant peptides that provide directional cues for the cell trafficking and thus are vital for protective host response. In addition, chemokines regulate plethora of biological processes of hematopoietic cells to lead cellular activation, differentiation and survival.
The chemokine signal is transduced by chemokine receptors (G-protein coupled receptors) expressed on the immune cells. After receptor activation, the alpha- and beta-gamma-subunits of G protein dissociate to activate diverse downstream pathways resulting in cellular polarization and actin reorganization. Various members of small GTPases are involved in this process. Induction of nitric oxide and production of reactive oxygen species are as well regulated by chemokine signal via calcium mobilization and diacylglycerol production.
Class
Organismal Systems; Immune system
Pathway map
oor04062  Chemokine signaling pathway
oor04062

Other DBs
GO: 0070098
Organism
Orcinus orca (killer whale) [GN:oor]
Gene
101285495  growth-regulated alpha protein-like isoform X1 [KO:K05505]
101277391  growth-regulated alpha protein-like [KO:K05505]
101285237  growth-regulated protein homolog beta-like [KO:K05505]
101277882  C-X-C motif chemokine 6 [KO:K05506]
101277637  PPBP; platelet basic protein [KO:K10029]
101278129  CXCL8; interleukin-8 [KO:K10030]
101289508  CXCL9; C-X-C motif chemokine 9 isoform X1 [KO:K05416]
101289273  CXCL10; C-X-C motif chemokine 10 [KO:K12671]
101274544  CXCL11; C-X-C motif chemokine 11 [KO:K12672]
101282620  CXCL12; stromal cell-derived factor 1 isoform X1 [KO:K10031]
101273565  CXCL13; C-X-C motif chemokine 13 [KO:K10032]
101281807  CXCL16; C-X-C motif chemokine 16 [KO:K10035]
101285751  platelet factor 4 [KO:K05407]
101283865  CXCL14; C-X-C motif chemokine 14 isoform X2 [KO:K10033]
101284912  lymphotactin isoform X1 [KO:K05507]
101280273  CX3CL1; fractalkine isoform X1 [KO:K05508]
101288892  CCL1; C-C motif chemokine 1 [KO:K05514]
101289706  C-C motif chemokine 2 [KO:K14624]
101274027  C-C motif chemokine 3-like [KO:K05408]
101283498  C-C motif chemokine 3-like [KO:K05408]
101283229  C-C motif chemokine 3-like [KO:K05408]
101274262  C-C motif chemokine 4 [KO:K12964]
101273776  C-C motif chemokine 5 isoform X2 [KO:K12499]
101290197  LOW QUALITY PROTEIN: C-C motif chemokine 8-like [KO:K16596]
101289951  eotaxin [KO:K16597]
101282728  CCL14; C-C motif chemokine 14 [KO:K21092]
101282476  CCL16; C-C motif chemokine 16 [KO:K21093]
101278908  CCL19; C-C motif chemokine 19 isoform X1 [KO:K05512]
101289519  CCL20; C-C motif chemokine 20 isoform X1 [KO:K14625]
101273206  CCL21; C-C motif chemokine 21 isoform X1 [KO:K16062]
101280028  CCL22; C-C motif chemokine 22 [KO:K21095]
101276836  CCL24; C-C motif chemokine 24 [KO:K21097]
101289094  CCL25; C-C motif chemokine 25 [KO:K13072]
101285932  CCL26; C-C motif chemokine 26 [KO:K21096]
101272950  uncharacterized protein LOC101272950 [KO:K16598]
117203384  CCL27; LOW QUALITY PROTEIN: C-C motif chemokine 27 [KO:K16598]
101282795  CCL28; C-C motif chemokine 28 [KO:K05513]
101272299  CXCR2; C-X-C chemokine receptor type 2 isoform X1 [KO:K05050]
101272048  C-X-C chemokine receptor type 2 [KO:K04175]
101282664  CXCR3; C-X-C chemokine receptor type 3 isoform X1 [KO:K04188]
101270504  CXCR4; C-X-C chemokine receptor type 4 [KO:K04189]
101275689  CXCR5; C-X-C chemokine receptor type 5 [KO:K04190]
101273163  CXCR6; C-X-C chemokine receptor type 6 [KO:K04191]
101273427  XCR1; chemokine XC receptor 1 [KO:K04193]
101286558  CX3CR1; CX3C chemokine receptor 1 [KO:K04192]
101286817  CCR8; LOW QUALITY PROTEIN: C-C chemokine receptor type 8 [KO:K04183]
101273141  CCR6; C-C chemokine receptor type 6 [KO:K04181]
101272648  CCR9; C-C chemokine receptor type 9 [KO:K04184]
101271544  CCR4; C-C chemokine receptor type 4 [KO:K04179]
101271312  CCR7; C-C chemokine receptor type 7 [KO:K04182]
101274157  C-C chemokine receptor type 2 isoform X1 [KO:K04177]
101273680  C-C chemokine receptor type 1 [KO:K04176]
101273922  CCR3; C-C chemokine receptor type 3 [KO:K04178]
101285232  CCR10; C-C chemokine receptor type 10 [KO:K04185]
101283171  JAK3; tyrosine-protein kinase JAK3 [KO:K11218] [EC:2.7.10.2]
101272458  STAT1; signal transducer and activator of transcription 1-alpha/beta isoform X1 [KO:K11220]
101281591  STAT2; signal transducer and activator of transcription 2 isoform X1 [KO:K11221]
101281369  STAT3; signal transducer and activator of transcription 3 isoform X1 [KO:K04692]
101280265  STAT5B; signal transducer and activator of transcription 5B isoform X1 [KO:K11224]
101276500  GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630]
101277471  GNAI3; guanine nucleotide-binding protein G(i) subunit alpha-3 [KO:K04630]
101271719  GNAI1; guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
101278368  ADCY1; adenylate cyclase type 1 isoform X1 [KO:K08041] [EC:4.6.1.1]
101286207  ADCY2; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
101283651  ADCY3; adenylate cyclase type 3 isoform X1 [KO:K08043] [EC:4.6.1.1]
101289858  ADCY4; adenylate cyclase type 4 isoform X2 [KO:K08044] [EC:4.6.1.1]
101283178  ADCY5; adenylate cyclase type 5 isoform X2 [KO:K08045] [EC:4.6.1.1]
101273023  ADCY6; adenylate cyclase type 6 isoform X1 [KO:K08046] [EC:4.6.1.1]
101273592  ADCY7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
101273171  ADCY8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
101281654  ADCY9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
101272376  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
101273911  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
101280666  LYN; tyrosine-protein kinase Lyn isoform X2 [KO:K05854] [EC:2.7.10.2]
101288667  HCK; tyrosine-protein kinase HCK isoform X1 [KO:K08893] [EC:2.7.10.2]
101269287  FGR; tyrosine-protein kinase Fgr isoform X2 [KO:K08891] [EC:2.7.10.2]
101275089  SRC; proto-oncogene tyrosine-protein kinase Src isoform X3 [KO:K05704] [EC:2.7.10.2]
101276908  SHC1; SHC-transforming protein 1 isoform X2 [KO:K06279]
101275665  SHC2; SHC-transforming protein 2 isoform X1 [KO:K17447]
101280480  SHC3; SHC-transforming protein 3 isoform X2 [KO:K17448]
101289594  SHC4; SHC-transforming protein 4 isoform X4 [KO:K17449]
101271441  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
101286587  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
105748221  LOW QUALITY PROTEIN: son of sevenless homolog 2-like [KO:K03099]
101284580  SOS2; son of sevenless homolog 2 isoform X2 [KO:K03099]
101271947  GTPase HRas-like isoform X4 [KO:K02833]
101286301  HRAS; GTPase HRas isoform X2 [KO:K02833]
101281897  KRAS; GTPase KRas isoform X2 [KO:K07827]
101276138  NRAS; GTPase NRas [KO:K07828]
101272984  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
101277195  BRAF; serine/threonine-protein kinase B-raf isoform X4 [KO:K04365] [EC:2.7.11.1]
101286388  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
101273287  MAPK1; mitogen-activated protein kinase 1 isoform X1 [KO:K04371] [EC:2.7.11.24]
101289394  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
101278075  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
101278974  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X2 [KO:K00922] [EC:2.7.1.153]
101283011  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
101277568  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
101285437  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
101281352  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta isoform X2 [KO:K02649]
101281782  PIK3CG; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform isoform X1 [KO:K21289] [EC:2.7.1.153]
101275916  PIK3R6; phosphoinositide 3-kinase regulatory subunit 6 isoform X1 [KO:K21290]
101275667  PIK3R5; phosphoinositide 3-kinase regulatory subunit 5 isoform X1 [KO:K21290]
101283233  PRKCZ; protein kinase C zeta type isoform X3 [KO:K18952] [EC:2.7.11.13]
101272095  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
101288103  AKT3; RAC-gamma serine/threonine-protein kinase isoform X2 [KO:K04456] [EC:2.7.11.1]
101273316  AKT1; RAC-alpha serine/threonine-protein kinase isoform X2 [KO:K04456] [EC:2.7.11.1]
101288204  FOXO3; LOW QUALITY PROTEIN: forkhead box protein O3 [KO:K09408]
101281072  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
101285763  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
101272428  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
101289477  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
101279981  NFKBIB; NF-kappa-B inhibitor beta [KO:K02581]
101279857  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
101270342  RELA; transcription factor p65 isoform X1 [KO:K04735]
101274967  BAD; bcl2-associated agonist of cell death [KO:K02158]
101281974  GSK3A; glycogen synthase kinase-3 alpha [KO:K08822] [EC:2.7.11.26]
101283259  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
101282766  ITK; tyrosine-protein kinase ITK/TSK isoform X1 [KO:K07363] [EC:2.7.10.2]
101290166  VAV3; guanine nucleotide exchange factor VAV3 isoform X1 [KO:K05730]
101269690  VAV2; guanine nucleotide exchange factor VAV2 isoform X11 [KO:K05730]
101282339  VAV1; LOW QUALITY PROTEIN: proto-oncogene vav [KO:K05730]
101274018  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X3 [KO:K04392]
101269741  RAC2; ras-related C3 botulinum toxin substrate 2 isoform X1 [KO:K07860]
101278177  RAC3; ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861]
101288086  PAK1; serine/threonine-protein kinase PAK 1 isoform X2 [KO:K04409] [EC:2.7.11.1]
101270289  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
101289436  WAS; actin nucleation-promoting factor WAS [KO:K05747]
101273830  RHOA; transforming protein RhoA [KO:K04513]
101278979  ROCK1; rho-associated protein kinase 1 isoform X1 [KO:K04514] [EC:2.7.11.1]
101289250  ROCK2; rho-associated protein kinase 2 [KO:K17388] [EC:2.7.11.1]
101282575  GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
101277504  GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
101286052  GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 [KO:K07825]
101277343  GNB4; guanine nucleotide-binding protein subunit beta-4 isoform X1 [KO:K04538]
101270085  GNB5; guanine nucleotide-binding protein subunit beta-5 isoform X2 [KO:K04539]
101270764  GNG2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 [KO:K07826]
101282693  GNG3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
101271265  GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
101276063  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
117197871  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5-like [KO:K04542]
117202102  GNG5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
117202794  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5-like [KO:K04542]
117198830  GNG7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543]
117201789  GNG8; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 [KO:K04544]
105747741  GNG10; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
117202637  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10-like [KO:K04545]
101290360  GNG11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
101281533  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
117201513  GNG13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547]
101269282  GNGT1; guanine nucleotide-binding protein G(T) subunit gamma-T1 [KO:K04548]
117197734  GNGT2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 [KO:K04549]
101283620  PREX1; phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein isoform X1 [KO:K12365]
101288983  ELMO1; engulfment and cell motility protein 1 isoform X3 [KO:K12366]
101284407  DOCK2; dedicator of cytokinesis protein 2 isoform X1 [KO:K12367]
101275490  PTK2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
101283112  PXN; paxillin isoform X6 [KO:K05760]
101286283  BCAR1; breast cancer anti-estrogen resistance protein 1 isoform X1 [KO:K05726]
101270546  CRKL; crk-like protein [KO:K04438]
101284062  CRK; adapter molecule crk isoform X1 [KO:K04438]
101281402  PTK2B; protein-tyrosine kinase 2-beta isoform X2 [KO:K05871] [EC:2.7.10.2]
101279781  guanine nucleotide-binding protein G(q) subunit alpha isoform X1 [KO:K04634]
101274558  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform X1 [KO:K05858] [EC:3.1.4.11]
101270548  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
101270961  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
101281417  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X9 [KO:K05858] [EC:3.1.4.11]
101281412  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116] [EC:3.1.4.11]
101285216  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
101278371  RASGRP2; RAS guanyl-releasing protein 2 isoform X4 [KO:K12361]
101287340  RAP1A; ras-related protein Rap-1A isoform X1 [KO:K04353]
101284281  RAP1B; ras-related protein Rap-1b [KO:K07836]
101280921  PARD3; partitioning defective 3 homolog isoform X3 [KO:K04237]
101280455  TIAM1; rho guanine nucleotide exchange factor TIAM1 isoform X1 [KO:K05731]
101277002  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
101275504  PRKCD; protein kinase C delta type isoform X1 [KO:K06068] [EC:2.7.11.13]
101276678  NCF1; neutrophil cytosol factor 1 isoform X2 [KO:K08011]
101275444  GRK1; rhodopsin kinase GRK1 [KO:K00909] [EC:2.7.11.14]
101277706  GRK7; rhodopsin kinase GRK7 [KO:K00909] [EC:2.7.11.14]
101283682  GRK2; beta-adrenergic receptor kinase 1 [KO:K00910] [EC:2.7.11.15]
101270842  GRK3; beta-adrenergic receptor kinase 2 isoform X1 [KO:K00910] [EC:2.7.11.15]
101276909  GRK6; G protein-coupled receptor kinase 6 isoform X2 [KO:K08291] [EC:2.7.11.16]
101275494  GRK5; G protein-coupled receptor kinase 5 isoform X3 [KO:K08291] [EC:2.7.11.16]
101280858  ARRB1; beta-arrestin-1 isoform X1 [KO:K04439]
125962100  ARRB2; beta-arrestin-2 isoform X1 [KO:K04439]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:12495636
  Authors
Wong MM, Fish EN
  Title
Chemokines: attractive mediators of the immune response.
  Journal
Semin Immunol 15:5-14 (2003)
DOI:10.1016/S1044-5323(02)00123-9
Reference
PMID:11872087
  Authors
Curnock AP, Logan MK, Ward SG
  Title
Chemokine signalling: pivoting around multiple phosphoinositide 3-kinases.
  Journal
Immunology 105:125-36 (2002)
DOI:10.1046/j.1365-2567.2002.01345.x
Reference
PMID:12069927
  Authors
Olson TS, Ley K
  Title
Chemokines and chemokine receptors in leukocyte trafficking.
  Journal
Am J Physiol Regul Integr Comp Physiol 283:R7-28 (2002)
DOI:10.1152/ajpregu.00738.2001
Reference
PMID:17169327
  Authors
Busillo JM, Benovic JL
  Title
Regulation of CXCR4 signaling.
  Journal
Biochim Biophys Acta 1768:952-63 (2007)
DOI:10.1016/j.bbamem.2006.11.002
Reference
PMID:11244042
  Authors
Mellado M, Rodriguez-Frade JM, Manes S, Martinez-A C
  Title
Chemokine signaling and functional responses: the role of receptor dimerization and TK pathway activation.
  Journal
Annu Rev Immunol 19:397-421 (2001)
DOI:10.1146/annurev.immunol.19.1.397
Reference
PMID:8576262
  Authors
Knall C, Young S, Nick JA, Buhl AM, Worthen GS, Johnson GL
  Title
Interleukin-8 regulation of the Ras/Raf/mitogen-activated protein kinase pathway in human neutrophils.
  Journal
J Biol Chem 271:2832-8 (1996)
DOI:10.1074/jbc.271.5.2832
Reference
PMID:17537990
  Authors
Patrussi L, Ulivieri C, Lucherini OM, Paccani SR, Gamberucci A, Lanfrancone L, Pelicci PG, Baldari CT
  Title
p52Shc is required for CXCR4-dependent signaling and chemotaxis in T cells.
  Journal
Blood 110:1730-8 (2007)
DOI:10.1182/blood-2007-01-068411
Reference
PMID:18662984
  Authors
Sai J, Raman D, Liu Y, Wikswo J, Richmond A
  Title
Parallel phosphatidylinositol 3-kinase (PI3K)-dependent and Src-dependent pathways lead to CXCL8-mediated Rac2 activation and chemotaxis.
  Journal
J Biol Chem 283:26538-47 (2008)
DOI:10.1074/jbc.M805611200
Reference
PMID:10852130
  Authors
Hauck CR, Klingbeil CK, Schlaepfer DD
  Title
Focal adhesion kinase functions as a receptor-proximal signaling component required for directed cell migration.
  Journal
Immunol Res 21:293-303 (2000)
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Reference
PMID:14625285
  Authors
Chandrasekar B, Bysani S, Mummidi S
  Title
CXCL16 signals via Gi, phosphatidylinositol 3-kinase, Akt, I kappa B kinase, and nuclear factor-kappa B and induces cell-cell adhesion and aortic smooth muscle cell proliferation.
  Journal
J Biol Chem 279:3188-96 (2004)
DOI:10.1074/jbc.M311660200
Reference
PMID:17371236
  Authors
Smith L, Webb A, Ward SG
  Title
T-lymphocyte navigation and migration: beyond the PI3K paradigm.
  Journal
Biochem Soc Trans 35:193-8 (2007)
DOI:10.1042/BST0350193
Reference
PMID:16144840
  Authors
Huttenrauch F, Pollok-Kopp B, Oppermann M
  Title
G protein-coupled receptor kinases promote phosphorylation and beta-arrestin-mediated internalization of CCR5 homo- and hetero-oligomers.
  Journal
J Biol Chem 280:37503-15 (2005)
DOI:10.1074/jbc.M500535200
Reference
PMID:18711432
  Authors
Thelen M, Stein JV
  Title
How chemokines invite leukocytes to dance.
  Journal
Nat Immunol 9:953-9 (2008)
DOI:10.1038/ni.f.207
Reference
PMID:19159344
  Authors
Ward SG, Marelli-Berg FM
  Title
Mechanisms of chemokine and antigen-dependent T-lymphocyte navigation.
  Journal
Biochem J 418:13-27 (2009)
DOI:10.1042/BJ20081969
Reference
PMID:15803148
  Authors
Schwartzberg PL, Finkelstein LD, Readinger JA
  Title
TEC-family kinases: regulators of T-helper-cell differentiation.
  Journal
Nat Rev Immunol 5:284-95 (2005)
DOI:10.1038/nri1591
Reference
PMID:15771581
  Authors
Berg LJ, Finkelstein LD, Lucas JA, Schwartzberg PL.
  Title
Tec family kinases in T lymphocyte development and function.
  Journal
Annu Rev Immunol 23:549-600 (2005)
DOI:10.1146/annurev.immunol.22.012703.104743
Reference
PMID:17496928
  Authors
Ticchioni M, Essafi M, Jeandel PY, Davi F, Cassuto JP, Deckert M, Bernard A
  Title
Homeostatic chemokines increase survival of B-chronic lymphocytic leukemia cells through inactivation of transcription factor FOXO3a.
  Journal
Oncogene 26:7081-91 (2007)
DOI:10.1038/sj.onc.1210519
Reference
PMID:9765254
  Authors
Korchak HM, Rossi MW, Kilpatrick LE
  Title
Selective role for beta-protein kinase C in signaling for O-2 generation but not degranulation or adherence in differentiated HL60 cells.
  Journal
J Biol Chem 273:27292-9 (1998)
DOI:10.1074/jbc.273.42.27292
Reference
PMID:15046611
  Authors
Johnson Z, Power CA, Weiss C, Rintelen F, Ji H, Ruckle T, Camps M, Wells TN, Schwarz MK, Proudfoot AE, Rommel C
  Title
Chemokine inhibition--why, when, where, which and how?
  Journal
Biochem Soc Trans 32:366-77 (2004)
DOI:10.1042/bst0320366
Reference
PMID:12051620
  Authors
Zhelev DV, Alteraifi A
  Title
Signaling in the motility responses of the human neutrophil.
  Journal
Ann Biomed Eng 30:356-70 (2002)
DOI:10.1114/1.1477446
Reference
PMID:17675482
  Authors
Bach TL, Chen QM, Kerr WT, Wang Y, Lian L, Choi JK, Wu D, Kazanietz MG, Koretzky GA, Zigmond S, Abrams CS
  Title
Phospholipase cbeta is critical for T cell chemotaxis.
  Journal
J Immunol 179:2223-7 (2007)
DOI:10.4049/jimmunol.179.4.2223
Reference
PMID:14607270
  Authors
Hornstein I, Alcover A, Katzav S
  Title
Vav proteins, masters of the world of cytoskeleton organization.
  Journal
Cell Signal 16:1-11 (2004)
DOI:10.1016/S0898-6568(03)00110-4
Related
pathway
oor04010  MAPK signaling pathway
oor04060  Cytokine-cytokine receptor interaction
oor04120  Ubiquitin mediated proteolysis
oor04630  JAK-STAT signaling pathway
oor04670  Leukocyte transendothelial migration
oor04810  Regulation of actin cytoskeleton
KO pathway
ko04062   
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