KEGG   PATHWAY: opi04072
Entry
opi04072                    Pathway                                
Name
Phospholipase D signaling pathway - Ochotona princeps (American pika)
Description
Phospholipase D (PLD) is an essential enzyme responsible for the production of the lipid second messenger phosphatidic acid (PA), which is involved in fundamental cellular processes, including membrane trafficking, actin cytoskeleton remodeling, cell proliferation and cell survival. PLD activity can be stimulated by a large number of cell surface receptors and is elaborately regulated by intracellular factors, including protein kinase C isoforms, small GTPases of the ARF, Rho and Ras families and the phosphoinositide, phosphatidylinositol 4,5-bisphosphate (PIP2). The PLD-produced PA activates signaling proteins and acts as a node within the membrane to which signaling proteins translocate. Several signaling proteins, including Raf-1 and mTOR, directly bind PA to mediate translocation or activation, respectively.
Class
Environmental Information Processing; Signal transduction
Pathway map
opi04072  Phospholipase D signaling pathway
opi04072

Organism
Ochotona princeps (American pika) [GN:opi]
Gene
101536206  EGF; pro-epidermal growth factor [KO:K04357]
101522887  PDGFB; platelet-derived growth factor subunit B [KO:K17386]
101529308  PDGFC; platelet-derived growth factor C [KO:K05450]
101529042  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
101533974  KITLG; kit ligand isoform X1 [KO:K05461]
101533865  insulin isoform X2 [KO:K04526]
101516125  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
101516431  PDGFRB; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
101536689  KIT; mast/stem cell growth factor receptor Kit [KO:K05091] [EC:2.7.10.1]
101530887  INSR; insulin receptor [KO:K04527] [EC:2.7.10.1]
101531037  GRB2; growth factor receptor-bound protein 2 isoform X1 [KO:K04364]
101535368  GAB1; GRB2-associated-binding protein 1 [KO:K09593]
101524341  GAB2; GRB2-associated-binding protein 2 [KO:K08091]
101529134  SHC1; SHC-transforming protein 1 isoform X1 [KO:K06279]
101522080  SHC2; SHC-transforming protein 2 [KO:K17447]
101522287  SHC3; SHC-transforming protein 3 [KO:K17448]
101535980  SHC4; SHC-transforming protein 4 [KO:K17449]
101529639  PTPN11; tyrosine-protein phosphatase non-receptor type 11 [KO:K07293] [EC:3.1.3.48]
101534610  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
101525349  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
101531636  HRAS; GTPase HRas [KO:K02833]
101534080  KRAS; GTPase KRas isoform X1 [KO:K07827]
101524465  NRAS; GTPase NRas [KO:K07828]
101520719  ras-related protein M-Ras-like [KO:K07831]
101532780  MRAS; ras-related protein M-Ras [KO:K07831]
101522344  RRAS; ras-related protein R-Ras [KO:K07829]
101521899  RRAS2; ras-related protein R-Ras2 [KO:K07830]
101534158  RALGDS; ral guanine nucleotide dissociation stimulator [KO:K08732]
101523024  RALA; ras-related protein Ral-A [KO:K07834]
101524724  RALB; ras-related protein Ral-B [KO:K07835]
101519449  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
101533851  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X3 [KO:K00922] [EC:2.7.1.153]
101533024  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
101532354  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
101517982  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
101528030  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
101533296  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
101519021  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
101525801  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
101520687  TSC1; hamartin [KO:K07206]
101519464  TSC2; tuberin isoform X2 [KO:K07207]
101535564  RHEB; GTP-binding protein Rheb [KO:K07208]
101525384  MTOR; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
101525255  RHOA; transforming protein RhoA isoform X1 [KO:K04513]
101535305  transforming protein RhoA-like isoform X1 [KO:K04513]
101522396  ADP-ribosylation factor 1-like [KO:K07937]
101531348  ARF1; ADP-ribosylation factor 1 [KO:K07937]
101520295  ADP-ribosylation factor 2-like [KO:K07937]
101529857  ADP-ribosylation factor 1-like [KO:K07937]
101524871  ARF6; ADP-ribosylation factor 6 [KO:K07941]
101522314  ADP-ribosylation factor 6-like [KO:K07941]
101520175  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116] [EC:3.1.4.11]
101526399  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
101536761  FCER1A; high affinity immunoglobulin epsilon receptor subunit alpha [KO:K08089]
101516352  MS4A2; high affinity immunoglobulin epsilon receptor subunit beta [KO:K08090]
101521326  FCER1G; high affinity immunoglobulin epsilon receptor subunit gamma [KO:K07983]
101517134  FYN; tyrosine-protein kinase Fyn isoform X1 [KO:K05703] [EC:2.7.10.2]
101521299  SYK; tyrosine-protein kinase SYK [KO:K05855] [EC:2.7.10.2]
101523549  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
101523215  PLD1; phospholipase D1 isoform X1 [KO:K01115] [EC:3.1.4.4]
101521179  PLD2; phospholipase D2 isoform X1 [KO:K01115] [EC:3.1.4.4]
101523982  PLA2G4F; cytosolic phospholipase A2 zeta [KO:K16342] [EC:3.1.1.4]
101524217  PLA2G4D; cytosolic phospholipase A2 delta [KO:K16342] [EC:3.1.1.4]
101524453  PLA2G4E; cytosolic phospholipase A2 epsilon [KO:K16342] [EC:3.1.1.4]
101524927  PLA2G4B; cytosolic phospholipase A2 beta [KO:K16342] [EC:3.1.1.4]
101520966  PLA2G4A; cytosolic phospholipase A2 [KO:K16342] [EC:3.1.1.4]
101517442  PLA2G4C; cytosolic phospholipase A2 gamma [KO:K16342] [EC:3.1.1.4]
101516235  AGPAT1; 1-acyl-sn-glycerol-3-phosphate acyltransferase alpha isoform X1 [KO:K13509] [EC:2.3.1.51]
101530584  AGPAT2; 1-acyl-sn-glycerol-3-phosphate acyltransferase beta [KO:K13509] [EC:2.3.1.51]
101535563  AGPAT3; 1-acyl-sn-glycerol-3-phosphate acyltransferase gamma [KO:K13523] [EC:2.3.1.51 2.3.1.-]
101518173  AGPAT4; 1-acyl-sn-glycerol-3-phosphate acyltransferase delta [KO:K13523] [EC:2.3.1.51 2.3.1.-]
101520762  AGPAT5; 1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon [KO:K19007] [EC:2.3.1.51]
101522095  LOW QUALITY PROTEIN: 1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon-like [KO:K19007] [EC:2.3.1.51]
101522075  SPHK1; sphingosine kinase 1 [KO:K04718] [EC:2.7.1.91]
101529238  SPHK2; sphingosine kinase 2 [KO:K04718] [EC:2.7.1.91]
101534290  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X2 [KO:K04366] [EC:2.7.11.1]
101533612  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
105942099  LOW QUALITY PROTEIN: dual specificity mitogen-activated protein kinase kinase 2-like [KO:K04369] [EC:2.7.12.2]
101529486  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
101530701  MAPK3; mitogen-activated protein kinase 3 isoform X1 [KO:K04371] [EC:2.7.11.24]
101525427  mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
101533422  PIP5K1A; phosphatidylinositol 4-phosphate 5-kinase type-1 alpha [KO:K00889] [EC:2.7.1.68]
101527580  PIP5K1B; phosphatidylinositol 4-phosphate 5-kinase type-1 beta [KO:K00889] [EC:2.7.1.68]
101524273  PIP5K1C; phosphatidylinositol 4-phosphate 5-kinase type-1 gamma [KO:K00889] [EC:2.7.1.68]
101516214  DGKI; diacylglycerol kinase iota [KO:K00901] [EC:2.7.1.107]
101528388  DGKB; diacylglycerol kinase beta isoform X1 [KO:K00901] [EC:2.7.1.107]
101532708  DGKG; diacylglycerol kinase gamma isoform X1 [KO:K00901] [EC:2.7.1.107]
101516062  DGKD; diacylglycerol kinase delta isoform X1 [KO:K00901] [EC:2.7.1.107]
101531701  DGKH; diacylglycerol kinase eta isoform X1 [KO:K00901] [EC:2.7.1.107]
101531344  DGKZ; diacylglycerol kinase zeta isoform X1 [KO:K00901] [EC:2.7.1.107]
101534011  DGKE; diacylglycerol kinase epsilon isoform X1 [KO:K00901] [EC:2.7.1.107]
101527283  DGKQ; diacylglycerol kinase theta [KO:K00901] [EC:2.7.1.107]
101534969  DGKA; diacylglycerol kinase alpha [KO:K00901] [EC:2.7.1.107]
101521484  DGKK; diacylglycerol kinase kappa [KO:K00901] [EC:2.7.1.107]
101527889  PLPP1; phospholipid phosphatase 1 [KO:K01080] [EC:3.1.3.4]
101522587  PLPP2; phospholipid phosphatase 2 [KO:K01080] [EC:3.1.3.4]
101528957  PLPP3; phospholipid phosphatase 3 [KO:K01080] [EC:3.1.3.4]
101528466  F2; prothrombin isoform X1 [KO:K01313] [EC:3.4.21.5]
101532109  AGT; angiotensinogen [KO:K09821]
101529690  vasopressin-neurophysin 2-copeptin [KO:K05242]
101535726  CXCL8; interleukin-8 [KO:K10030]
101531941  AGTR1; type-1 angiotensin II receptor [KO:K04166]
101527899  F2R; proteinase-activated receptor 1 [KO:K03914]
101516509  GRM1; metabotropic glutamate receptor 1 isoform X1 [KO:K04603]
101516247  GRM2; metabotropic glutamate receptor 2 [KO:K04605]
101524230  GRM3; metabotropic glutamate receptor 3 isoform X1 [KO:K04606]
101517083  GRM4; metabotropic glutamate receptor 4 isoform X1 [KO:K04607]
101517326  GRM5; metabotropic glutamate receptor 5 [KO:K04604]
101520469  GRM6; metabotropic glutamate receptor 6 [KO:K04608]
101525338  GRM7; metabotropic glutamate receptor 7 isoform X1 [KO:K04609]
101524260  GRM8; metabotropic glutamate receptor 8 isoform X1 [KO:K04610]
101534050  AVPR1A; vasopressin V1a receptor [KO:K04226]
101531711  AVPR1B; vasopressin V1b receptor [KO:K04227]
101522604  AVPR2; vasopressin V2 receptor [KO:K04228]
101531567  LPAR1; lysophosphatidic acid receptor 1 [KO:K04289]
101526026  LPAR2; lysophosphatidic acid receptor 2 [KO:K04291]
101532678  LPAR3; lysophosphatidic acid receptor 3 [KO:K04294]
101535560  LPAR4; lysophosphatidic acid receptor 4 [KO:K04275]
101531765  LPAR5; lysophosphatidic acid receptor 5 [KO:K08390]
101517362  LPAR6; lysophosphatidic acid receptor 6 [KO:K04273]
101529525  PTGFR; prostaglandin F2-alpha receptor [KO:K04262]
101532179  C-X-C chemokine receptor type 1 [KO:K04175]
101532421  CXCR2; C-X-C chemokine receptor type 2 [KO:K05050]
101524349  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
101524739  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
101529337  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11]
101520538  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform X2 [KO:K05858] [EC:3.1.4.11]
101525794  GNA12; guanine nucleotide-binding protein subunit alpha-12 isoform X1 [KO:K04346]
101526211  PTK2B; protein-tyrosine kinase 2-beta isoform X1 [KO:K05871] [EC:2.7.10.2]
101522146  GNA13; guanine nucleotide-binding protein subunit alpha-13 isoform X1 [KO:K04639]
101534593  PIK3CG; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform [KO:K21289] [EC:2.7.1.153]
101520859  PIK3R5; phosphoinositide 3-kinase regulatory subunit 5 [KO:K21290]
101533770  PIK3R6; phosphoinositide 3-kinase regulatory subunit 6 [KO:K21290]
101529012  CYTH3; cytohesin-3 isoform X1 [KO:K18441]
101521170  CYTH1; cytohesin-1 isoform X2 [KO:K18441]
101530489  CYTH2; cytohesin-2 isoform X1 [KO:K18441]
101531745  CYTH4; cytohesin-4 [KO:K18441]
101526074  neuroendocrine secretory protein 55-like [KO:K04632]
101533323  ADCY1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
101528674  ADCY2; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
101529277  ADCY3; adenylate cyclase type 3 isoform X1 [KO:K08043] [EC:4.6.1.1]
101527552  ADCY4; adenylate cyclase type 4 isoform X2 [KO:K08044] [EC:4.6.1.1]
101526286  ADCY5; adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
101528764  ADCY6; adenylate cyclase type 6 isoform X1 [KO:K08046] [EC:4.6.1.1]
101519430  ADCY7; adenylate cyclase type 7 [KO:K08047] [EC:4.6.1.1]
101523667  ADCY8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
101517485  ADCY9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
101523807  RAPGEF3; rap guanine nucleotide exchange factor 3 [KO:K08014]
101534512  RAPGEF4; rap guanine nucleotide exchange factor 4 [KO:K04351]
101528744  DNM3; dynamin-3 [KO:K01528] [EC:3.6.5.5]
101526595  DNM1; dynamin-1 isoform X1 [KO:K01528] [EC:3.6.5.5]
101535495  DNM2; dynamin-2 [KO:K23484] [EC:3.6.5.5]
Compound
C00025  L-Glutamate
C00076  Calcium cation
C00165  Diacylglycerol
C00416  Phosphatidate
C00575  3',5'-Cyclic AMP
C00639  Prostaglandin F2alpha
C00681  1-Acyl-sn-glycerol 3-phosphate
C01245  D-myo-Inositol 1,4,5-trisphosphate
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C06124  Sphingosine 1-phosphate
Reference
PMID:17245604
  Authors
Oude Weernink PA, Lopez de Jesus M, Schmidt M
  Title
Phospholipase D signaling: orchestration by PIP2 and small GTPases.
  Journal
Naunyn Schmiedebergs Arch Pharmacol 374:399-411 (2007)
DOI:10.1007/s00210-007-0131-4
Reference
PMID:21936578
  Authors
Selvy PE, Lavieri RR, Lindsley CW, Brown HA
  Title
Phospholipase D: enzymology, functionality, and chemical modulation.
  Journal
Chem Rev 111:6064-119 (2011)
DOI:10.1021/cr200296t
Reference
PMID:24995811
  Authors
Brandenburg LO, Pufe T, Koch T
  Title
Role of phospholipase d in g-protein coupled receptor function.
  Journal
Membranes (Basel) 4:302-18 (2014)
DOI:10.3390/membranes4030302
Reference
PMID:17054901
  Authors
Oude Weernink PA, Han L, Jakobs KH, Schmidt M
  Title
Dynamic phospholipid signaling by G protein-coupled receptors.
  Journal
Biochim Biophys Acta 1768:888-900 (2007)
DOI:10.1016/j.bbamem.2006.09.012
Reference
PMID:24990952
  Authors
Foster DA, Salloum D, Menon D, Frias MA
  Title
Phospholipase D and the maintenance of phosphatidic acid levels for regulation of mammalian target of rapamycin (mTOR).
  Journal
J Biol Chem 289:22583-8 (2014)
DOI:10.1074/jbc.R114.566091
Reference
PMID:16143829
  Authors
Jenkins GM, Frohman MA
  Title
Phospholipase D: a lipid centric review.
  Journal
Cell Mol Life Sci 62:2305-16 (2005)
DOI:10.1007/s00018-005-5195-z
Reference
PMID:19815110
  Authors
Metcalfe DD, Peavy RD, Gilfillan AM
  Title
Mechanisms of mast cell signaling in anaphylaxis.
  Journal
J Allergy Clin Immunol 124:639-46; quiz 647-8 (2009)
DOI:10.1016/j.jaci.2009.08.035
Reference
PMID:18936782
  Authors
Kalesnikoff J, Galli SJ
  Title
New developments in mast cell biology.
  Journal
Nat Immunol 9:1215-23 (2008)
DOI:10.1038/ni.f.216
Reference
PMID:12217395
  Authors
Cockcroft S, Way G, O'Luanaigh N, Pardo R, Sarri E, Fensome A
  Title
Signalling role for ARF and phospholipase D in mast cell exocytosis stimulated by crosslinking of the high affinity FcepsilonR1 receptor.
  Journal
Mol Immunol 38:1277-82 (2002)
DOI:10.1016/S0161-5890(02)00075-5
Reference
PMID:19410013
  Authors
Lee CS, Kim KL, Jang JH, Choi YS, Suh PG, Ryu SH
  Title
The roles of phospholipase D in EGFR signaling.
  Journal
Biochim Biophys Acta 1791:862-8 (2009)
DOI:10.1016/j.bbalip.2009.04.007
Reference
PMID:16622417
  Authors
Lee CS, Kim IS, Park JB, Lee MN, Lee HY, Suh PG, Ryu SH
  Title
The phox homology domain of phospholipase D activates dynamin GTPase activity and accelerates EGFR endocytosis.
  Journal
Nat Cell Biol 8:477-84 (2006)
DOI:10.1038/ncb1401
Reference
PMID:14769825
  Authors
Kam Y, Exton JH
  Title
Role of phospholipase D1 in the regulation of mTOR activity by lysophosphatidic acid.
  Journal
FASEB J 18:311-9 (2004)
DOI:10.1096/fj.03-0731com
Reference
PMID:9310372
  Authors
Kozawa O, Blume-Jensen P, Heldin CH, Ronnstrand L
  Title
Involvement of phosphatidylinositol 3'-kinase in stem-cell-factor-induced phospholipase D activation and arachidonic acid release.
  Journal
Eur J Biochem 248:149-55 (1997)
DOI:10.1111/j.1432-1033.1997.00149.x
Reference
PMID:11042115
  Authors
Slaaby R, Du G, Altshuller YM, Frohman MA, Seedorf K
  Title
Insulin-induced phospholipase D1 and phospholipase D2 activity in human embryonic kidney-293 cells mediated by the phospholipase C gamma and protein kinase C alpha signalling cascade.
  Journal
Biochem J 351 Pt 3:613-9 (2000)
DOI:10.1042/bj3510613
Reference
PMID:11991733
  Authors
Fahimi-Vahid M, Gosau N, Michalek C, Han L, Jakobs KH, Schmidt M, Roberts N, Avkiran M, Wieland T
  Title
Distinct signaling pathways mediate cardiomyocyte phospholipase D stimulation by endothelin-1 and thrombin.
  Journal
J Mol Cell Cardiol 34:441-53 (2002)
DOI:10.1006/jmcc.2002.1525
Reference
PMID:10666319
  Authors
Freeman EJ
  Title
The Ang II-induced growth of vascular smooth muscle cells involves a phospholipase D-mediated signaling mechanism.
  Journal
Arch Biochem Biophys 374:363-70 (2000)
DOI:10.1006/abbi.1999.1608
Reference
PMID:9119890
  Authors
Naro F, Donchenko V, Minotti S, Zolla L, Molinaro M, Adamo S
  Title
Role of phospholipase C and D signalling pathways in vasopressin-dependent myogenic differentiation.
  Journal
J Cell Physiol 171:34-42 (1997)
DOI:10.1002/(SICI)1097-4652(199704)171:1<34::AID-JCP5>3.0.CO;2-I
Reference
PMID:10807766
  Authors
Murdoch C, Finn A
  Title
Chemokine receptors and their role in inflammation and infectious diseases.
  Journal
Blood 95:3032-43 (2000)
Reference
PMID:8135758
  Authors
Sugiyama T, Sakai T, Nozawa Y, Oka N
  Title
Prostaglandin F2 alpha-stimulated phospholipase D activation in osteoblast-like MC3T3-E1 cells: involvement in sustained 1,2-diacylglycerol production.
  Journal
Biochem J 298 ( Pt 2):479-84 (1994)
DOI:10.1042/bj2980479
Reference
PMID:17210675
  Authors
Foster DA
  Title
Regulation of mTOR by phosphatidic acid?
  Journal
Cancer Res 67:1-4 (2007)
DOI:10.1158/0008-5472.CAN-06-3016
Reference
PMID:15310762
  Authors
Delon C, Manifava M, Wood E, Thompson D, Krugmann S, Pyne S, Ktistakis NT
  Title
Sphingosine kinase 1 is an intracellular effector of phosphatidic acid.
  Journal
J Biol Chem 279:44763-74 (2004)
DOI:10.1074/jbc.M405771200
Reference
PMID:23076158
  Authors
Park JB, Lee CS, Jang JH, Ghim J, Kim YJ, You S, Hwang D, Suh PG, Ryu SH
  Title
Phospholipase signalling networks in cancer.
  Journal
Nat Rev Cancer 12:782-92 (2012)
DOI:10.1038/nrc3379
Reference
PMID:19264150
  Authors
Foster DA
  Title
Phosphatidic acid signaling to mTOR: signals for the survival of human cancer cells.
  Journal
Biochim Biophys Acta 1791:949-55 (2009)
DOI:10.1016/j.bbalip.2009.02.009
Related
pathway
opi00561  Glycerolipid metabolism
opi04010  MAPK signaling pathway
opi04014  Ras signaling pathway
opi04020  Calcium signaling pathway
opi04024  cAMP signaling pathway
opi04071  Sphingolipid signaling pathway
opi04144  Endocytosis
opi04150  mTOR signaling pathway
opi04151  PI3K-Akt signaling pathway
opi04664  Fc epsilon RI signaling pathway
KO pathway
ko04072   
LinkDB

DBGET integrated database retrieval system