KEGG   PATHWAY: opi04151
Entry
opi04151                    Pathway                                
Name
PI3K-Akt signaling pathway - Ochotona princeps (American pika)
Description
The phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, translation, proliferation, growth, and survival. The binding of growth factors to their receptor tyrosine kinase (RTK) or G protein-coupled receptors (GPCR) stimulates class Ia and Ib PI3K isoforms, respectively. PI3K catalyzes the production of phosphatidylinositol-3,4,5-triphosphate (PIP3) at the cell membrane. PIP3 in turn serves as a second messenger that helps to activate Akt. Once active, Akt can control key cellular processes by phosphorylating substrates involved in apoptosis, protein synthesis, metabolism, and cell cycle.
Class
Environmental Information Processing; Signal transduction
Pathway map
opi04151  PI3K-Akt signaling pathway
opi04151

Other DBs
GO: 0043491
Organism
Ochotona princeps (American pika) [GN:opi]
Gene
101516087  LAMA4; laminin subunit alpha-4 isoform X1 [KO:K06241]
101516125  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
101516195  CDK2; cyclin-dependent kinase 2 isoform X1 [KO:K02206] [EC:2.7.11.22]
101516227  GNG8; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 [KO:K04544]
101516330  LAMA3; laminin subunit alpha-3 isoform X1 [KO:K06240]
101516431  PDGFRB; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
101516513  ITGA9; integrin alpha-9 [KO:K06585]
101516514  [KO:K05719]
101516538  GNG7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543]
101516625  G6PC2; glucose-6-phosphatase 2 [KO:K01084] [EC:3.1.3.9]
101516664  CSF1R; macrophage colony-stimulating factor 1 receptor isoform X1 [KO:K05090] [EC:2.7.10.1]
101516820  ITGA10; integrin alpha-10 isoform X1 [KO:K06586]
101516827  GHR; growth hormone receptor [KO:K05080]
101516929  MAGI2; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 [KO:K05629]
101517015  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
101517071  SGK2; serine/threonine-protein kinase Sgk2 [KO:K13303] [EC:2.7.11.1]
101517362  LPAR6; lysophosphatidic acid receptor 6 [KO:K04273]
101517365  ATF6B; cyclic AMP-dependent transcription factor ATF-6 beta isoform X1 [KO:K09049]
101517543  BCL2; apoptosis regulator Bcl-2 [KO:K02161]
101517568  YWHAG; 14-3-3 protein gamma [KO:K16198]
101517668  CSF3R; granulocyte colony-stimulating factor receptor [KO:K05061]
101517747  ERBB3; receptor tyrosine-protein kinase erbB-3 [KO:K05084] [EC:2.7.10.1]
101517765  PKN1; serine/threonine-protein kinase N1 [KO:K06071] [EC:2.7.11.13]
101517781  TNXB; tenascin-X [KO:K06252]
101517852  EPOR; erythropoietin receptor [KO:K05079]
101517956  PIK3AP1; phosphoinositide 3-kinase adapter protein 1 [KO:K12230]
101517963  NTRK2; BDNF/NT-3 growth factors receptor isoform X3 [KO:K04360] [EC:2.7.10.1]
101517982  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
101518001  PPP2R5D; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform isoform X1 [KO:K11584]
101518020  [KO:K03456]
101518143  BCL2L1; bcl-2-like protein 1 [KO:K04570]
101518161  RELN; reelin [KO:K06249] [EC:3.4.21.-]
101518184  EIF4E2; eukaryotic translation initiation factor 4E type 2 isoform X1 [KO:K03259]
101518245  JAK2; tyrosine-protein kinase JAK2 [KO:K04447] [EC:2.7.10.2]
101518457  NR4A1; nuclear receptor subfamily 4 group A member 1 [KO:K04465]
101518605  PPP2R2C; protein phosphatase 2, regulatory subunit B, gamma isoform X1 [KO:K04354]
101518721  COL9A2; collagen alpha-2(IX) chain [KO:K08131]
101518739  COL2A1; collagen alpha-1(II) chain isoform X1 [KO:K19719]
101518744  FGF9; fibroblast growth factor 9 [KO:K04358]
101519018  MDM2; LOW QUALITY PROTEIN: E3 ubiquitin-protein ligase Mdm2 [KO:K06643] [EC:2.3.2.27]
101519021  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
101519227  FGF19; fibroblast growth factor 19 [KO:K22603]
101519353  FGF10; fibroblast growth factor 10 [KO:K04358]
101519449  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
101519464  TSC2; tuberin isoform X2 [KO:K07207]
101519475  FGF4; fibroblast growth factor 4 [KO:K04358]
101519504  YWHAQ; 14-3-3 protein theta [KO:K16197]
101519556  IL2; interleukin-2 [KO:K05429]
101519725  FGF3; fibroblast growth factor 3 [KO:K04358]
101519852  IL7R; interleukin-7 receptor subunit alpha [KO:K05072]
101519866  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
101519888  [KO:K05096] [EC:2.7.10.1]
101520285  FGF2; LOW QUALITY PROTEIN: fibroblast growth factor 2 [KO:K18497]
101520631  FGF7; fibroblast growth factor 7 [KO:K04358]
101520675  IL6R; interleukin-6 receptor subunit alpha [KO:K05055]
101520687  TSC1; hamartin [KO:K07206]
101520691  NOS3; nitric oxide synthase, endothelial isoform X1 [KO:K13242] [EC:1.14.13.39]
101520786  ITGA2B; integrin alpha-IIb [KO:K06476]
101520859  PIK3R5; phosphoinositide 3-kinase regulatory subunit 5 [KO:K21290]
101520923  EIF4E; eukaryotic translation initiation factor 4E isoform X1 [KO:K03259]
101520975  CCNE2; G1/S-specific cyclin-E2 [KO:K06626]
101521025  AREG; amphiregulin [KO:K09782]
101521052  PPP2R3B; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta [KO:K11583]
101521180  FGF22; fibroblast growth factor 22 [KO:K04358]
101521183  VEGFB; vascular endothelial growth factor B isoform X1 [KO:K16858]
101521255  [KO:K10167]
101521291  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
101521299  SYK; tyrosine-protein kinase SYK [KO:K05855] [EC:2.7.10.2]
101521309  RBL2; retinoblastoma-like protein 2 isoform X1 [KO:K16332]
101521365  THBS1; thrombospondin-1 [KO:K16857]
101521396  GNG5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
101521451  LAMA1; laminin subunit alpha-1 [KO:K05637]
101521555  ANGPT4; angiopoietin-4 [KO:K05467]
101521567  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
101521783  FOXO3; forkhead box protein O3 [KO:K09408]
101521997  [KO:K04659]
101522068  FGF17; fibroblast growth factor 17 [KO:K04358]
101522117  DDIT4; DNA damage-inducible transcript 4 protein [KO:K08270]
101522285  MYC; myc proto-oncogene protein [KO:K04377]
101522364  [KO:K06626]
101522465  ITGB7; integrin beta-7 [KO:K06590]
101522490  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
101522646  CRTC2; CREB-regulated transcription coactivator 2 isoform X2 [KO:K16333]
101522647  EFNA4; ephrin-A4 [KO:K05462]
101522654  CDKN1B; cyclin-dependent kinase inhibitor 1B [KO:K06624]
101522886  EFNA3; ephrin-A3 isoform X1 [KO:K05462]
101522887  PDGFB; platelet-derived growth factor subunit B [KO:K17386]
101523017  PHLPP1; PH domain leucine-rich repeat-containing protein phosphatase 1 [KO:K16340] [EC:3.1.3.16]
101523058  VEGFA; vascular endothelial growth factor A isoform X1 [KO:K05448]
101523167  PPP2R5A; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform [KO:K11584]
101523170  LAMC2; laminin subunit gamma-2 [KO:K06246]
101523190  EIF4B; eukaryotic translation initiation factor 4B [KO:K03258]
101523220  GYS2; glycogen [starch] synthase, liver [KO:K00693] [EC:2.4.1.11]
101523287  LAMA2; laminin subunit alpha-2 [KO:K05637]
101523375  EFNA1; ephrin-A1 [KO:K05462]
101523409  LAMC1; laminin subunit gamma-1 [KO:K05635]
101523417  YWHAZ; 14-3-3 protein zeta/delta isoform X1 [KO:K16197]
101523446  CREB3L4; cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X1 [KO:K09048]
101523476  BRCA1; breast cancer type 1 susceptibility protein [KO:K10605] [EC:2.3.2.27]
101523524  THBS4; thrombospondin-4 [KO:K04659]
101523537  IL2RB; interleukin-2 receptor subunit beta [KO:K05069]
101523549  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
101523562  [KO:K04079]
101523632  LAMC3; laminin subunit gamma-3 [KO:K06247]
101523678  TCL1A; T-cell leukemia/lymphoma protein 1A [KO:K10167]
101523730  TLR2; toll-like receptor 2 [KO:K10159]
101523761  PCK2; phosphoenolpyruvate carboxykinase [GTP], mitochondrial [KO:K01596] [EC:4.1.1.32]
101523790  EPHA2; ephrin type-A receptor 2 [KO:K05103] [EC:2.7.10.1]
101523800  NRTN; neurturin [KO:K25414]
101523908  COL9A1; collagen alpha-1(IX) chain [KO:K08131]
101523913  LAMB2; laminin subunit beta-2 [KO:K06243]
101523918  ITGB8; integrin beta-8 [KO:K06591]
101523925  TCL1B; T-cell leukemia/lymphoma protein 1B [KO:K16836]
101523935  FGFR4; fibroblast growth factor receptor 4 isoform X1 [KO:K05095] [EC:2.7.10.1]
101524034  ITGB4; integrin beta-4 isoform X1 [KO:K06525]
101524093  IL4; interleukin-4 isoform X1 [KO:K05430]
101524098  EIF4E1B; eukaryotic translation initiation factor 4E type 1B [KO:K03259]
101524206  FN1; fibronectin isoform X1 [KO:K05717]
101524335  IFNAR2; interferon alpha/beta receptor 2 [KO:K05131]
101524465  NRAS; GTPase NRas [KO:K07828]
101524512  GNG14; putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347]
101524610  FGF8; fibroblast growth factor 8 isoform X3 [KO:K04358]
101524703  HSP90AA1; heat shock protein HSP 90-alpha [KO:K04079]
101524731  NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
101524825  CCNE1; G1/S-specific cyclin-E1 [KO:K06626]
101524887  HSP90AB1; heat shock protein HSP 90-beta [KO:K04079]
101525011  CDC37; hsp90 co-chaperone Cdc37 [KO:K09554]
101525041  COL6A5; collagen alpha-5(VI) chain [KO:K06238]
101525047  HSP90B1; endoplasmin [KO:K09487]
101525183  PPP2R5C; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X1 [KO:K11584]
101525278  COL6A6; collagen alpha-6(VI) chain [KO:K06238]
101525305  TNR; tenascin-R isoform X1 [KO:K06252]
101525317  ITGB5; integrin beta-5 [KO:K06588]
101525349  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
101525384  MTOR; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
101525427  [KO:K04371] [EC:2.7.11.24]
101525429  EFNA5; ephrin-A5 isoform X1 [KO:K05462]
101525483  GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
101525496  TEK; angiopoietin-1 receptor [KO:K05121] [EC:2.7.10.1]
101525509  [KO:K07198] [EC:2.7.11.31]
101525551  G6PC3; glucose-6-phosphatase 3 isoform X1 [KO:K01084] [EC:3.1.3.9]
101525767  KDR; vascular endothelial growth factor receptor 2 isoform X2 [KO:K05098] [EC:2.7.10.1]
101525801  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
101525898  ITGA1; integrin alpha-1 [KO:K06480]
101525955  ITGB6; integrin beta-6 isoform X1 [KO:K06589]
101526004  IGF1; insulin-like growth factor I isoform X2 [KO:K05459]
101526026  LPAR2; lysophosphatidic acid receptor 2 [KO:K04291]
101526027  PSPN; persephin [KO:K25416]
101526036  COL4A3; collagen alpha-3(IV) chain [KO:K06237]
101526073  YWHAB; 14-3-3 protein beta/alpha [KO:K16197]
101526116  ATF2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
101526118  RPS6KB2; ribosomal protein S6 kinase beta-2 [KO:K04688] [EC:2.7.11.1]
101526149  ITGA2; integrin alpha-2 [KO:K06481]
101526197  IRS1; insulin receptor substrate 1 [KO:K16172]
101526282  COL4A4; collagen alpha-4(IV) chain [KO:K06237]
101526325  SGK1; serine/threonine-protein kinase Sgk1 isoform X1 [KO:K13302] [EC:2.7.11.1]
101526395  ITGA5; integrin alpha-5 [KO:K06484]
101526499  CASP9; caspase-9 [KO:K04399] [EC:3.4.22.62]
101526608  CHRM1; muscarinic acetylcholine receptor M1 [KO:K04129]
101526619  COL4A2; collagen alpha-2(IV) chain [KO:K06237]
101526738  IL2RA; interleukin-2 receptor subunit alpha [KO:K05068]
101526755  YWHAE; 14-3-3 protein epsilon [KO:K06630]
101526852  COL4A1; collagen alpha-1(IV) chain [KO:K06237]
101527000  PKN3; serine/threonine-protein kinase N3 [KO:K23692]
101527090  JAK3; tyrosine-protein kinase JAK3 [KO:K11218] [EC:2.7.10.2]
101527097  NTF4; neurotrophin-4 [KO:K12457]
101527218  PPP2CA; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
101527290  NGF; beta-nerve growth factor [KO:K02582]
101527471  MYB; transcriptional activator Myb isoform X1 [KO:K09420]
101527518  [KO:K04392]
101527578  ERBB2; receptor tyrosine-protein kinase erbB-2 isoform X4 [KO:K05083] [EC:2.7.10.1]
101527612  LAMB3; laminin subunit beta-3 [KO:K06244]
101527700  PTK2; focal adhesion kinase 1 isoform X21 [KO:K05725] [EC:2.7.10.2]
101527710  PGF; placenta growth factor [KO:K16859]
101527736  CHAD; chondroadherin [KO:K06248]
101527820  COL4A6; collagen alpha-6(IV) chain [KO:K06237]
101527848  GYS1; glycogen [starch] synthase, muscle isoform X1 [KO:K00693] [EC:2.4.1.11]
101527899  F2R; proteinase-activated receptor 1 [KO:K03914]
101528030  [KO:K02649]
101528071  COL4A5; collagen alpha-5(IV) chain [KO:K06237]
101528096  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
101528167  ARTN; artemin [KO:K25415]
101528222  BDNF; brain-derived neurotrophic factor isoform X1 [KO:K04355]
101528242  SPP1; osteopontin [KO:K06250]
101528245  ANGPT2; angiopoietin-2 isoform X1 [KO:K05466]
101528246  RPS6KB1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
101528266  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
101528309  PPP2R5E; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform isoform X1 [KO:K11584]
101528335  YWHAH; 14-3-3 protein eta [KO:K16198]
101528346  TP53; cellular tumor antigen p53 [KO:K04451]
101528351  FGF23; fibroblast growth factor 23 [KO:K22428]
101528473  PDPK1; 3-phosphoinositide-dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
101528482  NTRK1; high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
101528543  PKN2; serine/threonine-protein kinase N2 isoform X1 [KO:K23691]
101528594  FGF6; fibroblast growth factor 6 [KO:K04358]
101528599  [KO:K03259]
101528746  GNG3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
101528760  [KO:K08131]
101528794  PCK1; phosphoenolpyruvate carboxykinase, cytosolic [GTP] isoform X1 [KO:K01596] [EC:4.1.1.32]
101528942  GNG2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 [KO:K07826]
101529042  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
101529159  THBS2; thrombospondin-2 [KO:K04659]
101529212  [KO:K06253]
101529215  COL1A1; collagen alpha-1(I) chain [KO:K06236]
101529308  PDGFC; platelet-derived growth factor C [KO:K05450]
101529368  FGF1; fibroblast growth factor 1 [KO:K18496]
101529486  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
101529506  MTCP1; protein p13 MTCP-1 [KO:K16837]
101529521  RPS6; 40S ribosomal protein S6 [KO:K02991]
101529543  PRKAA2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 [KO:K07198] [EC:2.7.11.31]
101529615  GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
101529725  TNC; tenascin isoform X2 [KO:K06252]
101529734  FLT3LG; fms-related tyrosine kinase 3 ligand [KO:K05454]
101529935  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
101529966  BCL2L11; bcl-2-like protein 11 isoform X1 [KO:K16341]
101530065  VWF; von Willebrand factor [KO:K03900]
101530066  RELA; transcription factor p65 [KO:K04735]
101530070  ITGA6; integrin alpha-6 isoform X1 [KO:K06485]
101530123  PPP2R3A; LOW QUALITY PROTEIN: serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha [KO:K11583]
101530131  CSF3; granulocyte colony-stimulating factor [KO:K05423]
101530158  ITGA4; LOW QUALITY PROTEIN: integrin alpha-4 [KO:K06483]
101530218  ITGA3; integrin alpha-3 isoform X1 [KO:K06482]
101530318  NTF3; neurotrophin-3 [KO:K04356]
101530360  PRLR; prolactin receptor isoform X1 [KO:K05081]
101530437  CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
101530491  GH1; somatotropin [KO:K05438]
101530535  EPO; erythropoietin [KO:K05437]
101530547  GNB4; guanine nucleotide-binding protein subunit beta-4 [KO:K04538]
101530550  OSM; oncostatin-M [KO:K05418]
101530576  ITGA11; integrin alpha-11 [KO:K06587]
101530616  IL4R; interleukin-4 receptor subunit alpha [KO:K05071]
101530642  RXRA; retinoic acid receptor RXR-alpha isoform X2 [KO:K08524]
101530682  CDK6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
101530701  MAPK3; mitogen-activated protein kinase 3 isoform X1 [KO:K04371] [EC:2.7.11.24]
101530838  CSF1; macrophage colony-stimulating factor 1 [KO:K05453]
101530887  INSR; insulin receptor [KO:K04527] [EC:2.7.10.1]
101531037  GRB2; growth factor receptor-bound protein 2 isoform X1 [KO:K04364]
101531051  G6PC; glucose-6-phosphatase [KO:K01084] [EC:3.1.3.9]
101531170  [KO:K16198]
101531258  MLST8; target of rapamycin complex subunit LST8 isoform X2 [KO:K08266]
101531323  GNG10; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
101531329  IL6; interleukin-6 precursor [KO:K05405]
101531416  ANGPT1; angiopoietin-1 isoform X1 [KO:K05465]
101531468  STK11; serine/threonine-protein kinase STK11 [KO:K07298] [EC:2.7.11.1]
101531517  MCL1; induced myeloid leukemia cell differentiation protein Mcl-1 [KO:K02539]
101531567  LPAR1; lysophosphatidic acid receptor 1 [KO:K04289]
101531611  NFKB1; LOW QUALITY PROTEIN: nuclear factor NF-kappa-B p105 subunit [KO:K02580]
101531631  CCND1; G1/S-specific cyclin-D1 isoform X2 [KO:K04503]
101531636  HRAS; GTPase HRas [KO:K02833]
101531647  GNGT1; guanine nucleotide-binding protein G(T) subunit gamma-T1 [KO:K04548]
101531684  COL6A2; collagen alpha-2(VI) chain [KO:K06238]
101531698  VEGFD; vascular endothelial growth factor D [KO:K05449]
101531703  [KO:K05636]
101531710  GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
101531761  CREB3L2; cyclic AMP-responsive element-binding protein 3-like protein 2 [KO:K09048]
101531765  LPAR5; lysophosphatidic acid receptor 5 [KO:K08390]
101531818  CD19; B-lymphocyte antigen CD19 isoform X1 [KO:K06465]
101531844  TNN; tenascin-N [KO:K06252]
101531872  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
101531879  GNG11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
101531901  [KO:K13304] [EC:2.7.11.1]
101531922  COL6A1; collagen alpha-1(VI) chain [KO:K06238]
101532148  THBS3; thrombospondin-3 isoform X1 [KO:K04659]
101532237  CHRM2; muscarinic acetylcholine receptor M2 [KO:K04130]
101532346  GNB5; guanine nucleotide-binding protein subunit beta-5 [KO:K04539]
101532354  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
101532362  COL1A2; collagen alpha-2(I) chain [KO:K06236]
101532400  PPP2CB; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
101532426  FLT4; vascular endothelial growth factor receptor 3 [KO:K05097] [EC:2.7.10.1]
101532428  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
101532472  FGF16; fibroblast growth factor 16 [KO:K04358]
101532574  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
101532669  [KO:K05719]
101532678  LPAR3; lysophosphatidic acid receptor 3 [KO:K04294]
101532689  CREB3L1; cyclic AMP-responsive element-binding protein 3-like protein 1 [KO:K09048]
101532843  [KO:K05414]
101532855  GDNF; glial cell line-derived neurotrophic factor isoform X1 [KO:K05452]
101532921  CREB3; cyclic AMP-responsive element-binding protein 3 [KO:K09048]
101532982  EIF4EBP1; eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
101533024  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
101533081  [KO:K05414]
101533099  PPP2R2B; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X1 [KO:K04354]
101533103  FGF18; fibroblast growth factor 18 [KO:K04358]
101533176  LAMA5; laminin subunit alpha-5 [KO:K06240]
101533296  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
101533318  IFNB1; interferon beta [KO:K05415]
101533371  CREB3L3; cyclic AMP-responsive element-binding protein 3-like protein 3 [KO:K09048]
101533375  FGF21; fibroblast growth factor 21 [KO:K22429]
101533416  [KO:K06643] [EC:2.3.2.27]
101533552  PPP2R2A; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform [KO:K04354]
101533612  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
101533693  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
101533770  PIK3R6; phosphoinositide 3-kinase regulatory subunit 6 [KO:K21290]
101533851  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X3 [KO:K00922] [EC:2.7.1.153]
101533860  FLT1; vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
101533865  [KO:K04526]
101533974  KITLG; kit ligand isoform X1 [KO:K05461]
101533998  ITGA7; integrin alpha-7 isoform X1 [KO:K06583]
101534080  KRAS; GTPase KRas isoform X1 [KO:K07827]
101534148  GNGT2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 [KO:K04549]
101534278  IGF2; insulin-like growth factor II [KO:K13769]
101534290  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X2 [KO:K04366] [EC:2.7.11.1]
101534340  BAD; bcl2-associated agonist of cell death [KO:K02158]
101534350  FLT3; receptor-type tyrosine-protein kinase FLT3 [KO:K05092] [EC:2.7.10.1]
101534591  ERBB4; receptor tyrosine-protein kinase erbB-4 [KO:K05085] [EC:2.7.10.1]
101534593  PIK3CG; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform [KO:K21289] [EC:2.7.1.153]
101534608  CREB5; cyclic AMP-responsive element-binding protein 5 isoform X1 [KO:K09047]
101534610  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
101534850  MAGI1; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X1 [KO:K05631]
101534862  COL9A3; collagen alpha-3(IX) chain [KO:K08131]
101534918  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
101535058  MET; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
101535157  ITGAV; integrin alpha-V [KO:K06487]
101535171  VEGFC; vascular endothelial growth factor C [KO:K05449]
101535218  CCND3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
101535293  JAK1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
101535404  GNG13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547]
101535483  IGF1R; insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
101535530  PPP2R3C; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma isoform X1 [KO:K11583]
101535531  PPP2R1B; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X3 [KO:K03456]
101535560  LPAR4; lysophosphatidic acid receptor 4 [KO:K04275]
101535564  RHEB; GTP-binding protein Rheb [KO:K07208]
101535575  COL6A3; collagen alpha-3(VI) chain [KO:K06238]
101535621  THEM4; acyl-coenzyme A thioesterase THEM4 [KO:K16339] [EC:3.1.2.2]
101535653  FGF20; fibroblast growth factor 20 [KO:K04358]
101535660  RET; proto-oncogene tyrosine-protein kinase receptor Ret [KO:K05126] [EC:2.7.10.1]
101535717  PRL; prolactin isoform X1 [KO:K05439]
101535784  FGF5; fibroblast growth factor 5 [KO:K04358]
101535804  PPP2R5B; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform [KO:K11584]
101535938  IL7; interleukin-7 [KO:K05431]
101535964  ITGB3; integrin beta-3 [KO:K06493]
101535976  IKBKG; NF-kappa-B essential modulator [KO:K07210]
101536034  RPTOR; regulatory-associated protein of mTOR [KO:K07204]
101536045  EFNA2; ephrin-A2 [KO:K05462]
101536073  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
101536083  PRKAA1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform X1 [KO:K07198] [EC:2.7.11.31]
101536206  EGF; pro-epidermal growth factor [KO:K04357]
101536231  ITGA8; integrin alpha-8 [KO:K06584]
101536333  IL3RA; interleukin-3 receptor subunit alpha [KO:K04737]
101536351  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
101536416  PHLPP2; PH domain leucine-rich repeat-containing protein phosphatase 2 isoform X1 [KO:K16340] [EC:3.1.3.16]
101536535  TLR4; toll-like receptor 4 [KO:K10160]
101536616  IL2RG; cytokine receptor common subunit gamma isoform X2 [KO:K05070]
101536689  KIT; mast/stem cell growth factor receptor Kit [KO:K05091] [EC:2.7.10.1]
101536793  GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 isoform X1 [KO:K07825]
105942099  [KO:K04369] [EC:2.7.12.2]
105942284  VTN; vitronectin [KO:K06251]
118758092  [KO:K06240]
Compound
C00020  AMP
C00533  Nitric oxide
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:16847462
  Authors
Engelman JA, Luo J, Cantley LC
  Title
The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism.
  Journal
Nat Rev Genet 7:606-19 (2006)
DOI:10.1038/nrg1879
Reference
PMID:15784165
  Authors
Song G, Ouyang G, Bao S
  Title
The activation of Akt/PKB signaling pathway and cell survival.
  Journal
J Cell Mol Med 9:59-71 (2005)
DOI:10.1111/j.1582-4934.2005.tb00337.x
Reference
PMID:21620960
  Authors
Hers I, Vincent EE, Tavare JM
  Title
Akt signalling in health and disease.
  Journal
Cell Signal 23:1515-27 (2011)
DOI:10.1016/j.cellsig.2011.05.004
Reference
PMID:18842113
  Authors
Duronio V
  Title
The life of a cell: apoptosis regulation by the PI3K/PKB pathway.
  Journal
Biochem J 415:333-44 (2008)
DOI:10.1042/BJ20081056
Reference
PMID:16248975
  Authors
Kim D, Chung J.
  Title
Akt: versatile mediator of cell survival and beyond.
  Journal
J Biochem Mol Biol 35:106-15 (2002)
DOI:10.5483/bmbrep.2002.35.1.106
Reference
PMID:12660731
  Authors
Koyasu S
  Title
The role of PI3K in immune cells.
  Journal
Nat Immunol 4:313-9 (2003)
DOI:10.1038/ni0403-313
Reference
PMID:12669022
  Authors
Okkenhaug K, Vanhaesebroeck B.
  Title
PI3K in lymphocyte development, differentiation and activation.
  Journal
Nat Rev Immunol 3:317-30 (2003)
DOI:10.1038/nri1056
Reference
PMID:15209374
  Authors
Richardson CJ, Schalm SS, Blenis J
  Title
PI3-kinase and TOR: PIKTORing cell growth.
  Journal
Semin Cell Dev Biol 15:147-59 (2004)
DOI:10.1016/j.semcdb.2003.12.023
Reference
PMID:21440011
  Authors
Zhang X, Tang N, Hadden TJ, Rishi AK
  Title
Akt, FoxO and regulation of apoptosis.
  Journal
Biochim Biophys Acta 1813:1978-86 (2011)
DOI:10.1016/j.bbamcr.2011.03.010
Reference
PMID:21779440
  Authors
Georgescu MM
  Title
PTEN Tumor Suppressor Network in PI3K-Akt Pathway Control.
  Journal
Genes Cancer 1:1170-7 (2010)
DOI:10.1177/1947601911407325
Reference
PMID:12531180
  Authors
West KA, Castillo SS, Dennis PA
  Title
Activation of the PI3K/Akt pathway and chemotherapeutic resistance.
  Journal
Drug Resist Updat 5:234-48 (2002)
DOI:10.1016/S1368-7646(02)00120-6
Reference
PMID:9838078
  Authors
Wymann MP, Pirola L
  Title
Structure and function of phosphoinositide 3-kinases.
  Journal
Biochim Biophys Acta 1436:127-50 (1998)
DOI:10.1016/S0005-2760(98)00139-8
Reference
PMID:12048182
  Authors
Moelling K, Schad K, Bosse M, Zimmermann S, Schweneker M
  Title
Regulation of Raf-Akt Cross-talk.
  Journal
J Biol Chem 277:31099-106 (2002)
DOI:10.1074/jbc.M111974200
Reference
PMID:16187290
  Authors
Kikani CK, Dong LQ, Liu F
  Title
"New"-clear functions of PDK1: beyond a master kinase in the cytosol?
  Journal
J Cell Biochem 96:1157-62 (2005)
DOI:10.1002/jcb.20651
Reference
PMID:11357143
  Authors
Blume-Jensen P, Hunter T
  Title
Oncogenic kinase signalling.
  Journal
Nature 411:355-65 (2001)
DOI:10.1038/35077225
Reference
PMID:15505410
  Authors
Osaki M, Oshimura M, Ito H
  Title
PI3K-Akt pathway: its functions and alterations in human cancer.
  Journal
Apoptosis 9:667-76 (2004)
DOI:10.1023/B:APPT.0000045801.15585.dd
Reference
PMID:17360849
  Authors
Noguchi M, Ropars V, Roumestand C, Suizu F
  Title
Proto-oncogene TCL1: more than just a coactivator for Akt.
  Journal
FASEB J 21:2273-84 (2007)
DOI:10.1096/fj.06-7684com
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Related
pathway
opi00010  Glycolysis / Gluconeogenesis
opi04010  MAPK signaling pathway
opi04012  ErbB signaling pathway
opi04062  Chemokine signaling pathway
opi04064  NF-kappa B signaling pathway
opi04068  FoxO signaling pathway
opi04110  Cell cycle
opi04115  p53 signaling pathway
opi04150  mTOR signaling pathway
opi04210  Apoptosis
opi04370  VEGF signaling pathway
opi04510  Focal adhesion
opi04620  Toll-like receptor signaling pathway
opi04630  JAK-STAT signaling pathway
opi04662  B cell receptor signaling pathway
opi04910  Insulin signaling pathway
KO pathway
ko04151   

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