KEGG   PATHWAY: ptr04936
Entry
ptr04936                    Pathway                                
Name
Alcoholic liver disease - Pan troglodytes (chimpanzee)
Description
Alcoholic liver disease (ALD) refers to the damages to the liver and its functions due to alcohol overconsumption. It ranges from simple steatosis to steatohepatitis, cirrhosis, and even hepatocellular carcinoma. Alcohol consumption promotes liver inflammation by increasing the translocation of gut-derived endotoxins to the portal circulation and activating Kupffer cells to produce TNF-alpha through the LPS/Toll like receptor (TLR) 4 pathways. TNF-alpha induces hepatocellular damage. When alcohol intake is chronic and heavy, steatosis is caused via generation of acetaldehyde, reactive oxygen species (ROS) and ER stress. ROS inhibits key hepatic transcriptional regulators such as AMP-activated kinase (AMPK) and peroxisome proliferator-activated receptor alpha (PPAR-alpha), which are responsible for fatty acid oxidation and export via ACC and CPT-1. The blockade of AMPK also leads to overexpression of SREBP-1, resulting in an increase of de novo lipogenesis. Moreover, excessive intracellular ROS production induced by ethanol and its metabolite have a critical role in ethanol-induced apoptosis, which may be the critical process in the exacerbation of ALD. It is inferred that the apoptotic signal derived from ROS that was produced by NOX, is mainly transduced through the JNK and p38 MAPK pathways.
Class
Human Diseases; Endocrine and metabolic disease
Pathway map
ptr04936  Alcoholic liver disease
ptr04936

Organism
Pan troglodytes (chimpanzee) [GN:ptr]
Gene
469214  C1QB; complement C1q subcomponent subunit B [KO:K03987]
100608992  C2; complement C2 [KO:K01332] [EC:3.4.21.43]
462577  complement C4-A [KO:K03989]
100616513  C4A; complement C4-A precursor [KO:K03989]
455644  C3; complement C3 [KO:K03990]
466942  C3AR1; C3a anaphylatoxin chemotactic receptor [KO:K04009]
464703  C5; complement C5 isoform X7 [KO:K03994]
468931  C5AR1; C5a anaphylatoxin chemotactic receptor 1 isoform X2 [KO:K04010]
458239  LBP; lipopolysaccharide-binding protein isoform X1 [KO:K05399]
462118  CD14; monocyte differentiation antigen CD14 precursor [KO:K04391]
746178  LY96; lymphocyte antigen 96 precursor [KO:K05400]
743242  TLR4; toll-like receptor 4 precursor [KO:K10160]
451654  TIRAP; toll/interleukin-1 receptor domain-containing adapter protein [KO:K05403]
460269  MYD88; myeloid differentiation primary response protein MyD88 [KO:K04729]
451702  TRAF6; TNF receptor-associated factor 6 isoform X1 [KO:K03175] [EC:2.3.2.27]
458845  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 [KO:K04403]
463057  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1 [KO:K04404]
462888  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
450673  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
472749  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
100610002  NF-kappa-B essential modulator isoform X1 [KO:K07210]
100609537  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
467426  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
466665  RELA; transcription factor P65 [KO:K04735]
461406  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X3 [KO:K02580]
494186  TNF; tumor necrosis factor [KO:K03156]
450200  IL1B; interleukin-1 beta [KO:K04519]
463288  IL6; interleukin-6 isoform X1 [KO:K05405]
460816  IL12A; interleukin-12 subunit alpha isoform X1 [KO:K05406]
471723  IL12B; interleukin-12 subunit beta [KO:K05425]
471205  CXCL8; interleukin-8 [KO:K10030]
468677  TICAM1; TIR domain-containing adapter molecule 1 [KO:K05842]
453178  TRAF3; TNF receptor-associated factor 3 isoform X1 [KO:K03174]
742813  IKBKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X1 [KO:K07211] [EC:2.7.11.10]
452047  TBK1; serine/threonine-protein kinase TBK1 [KO:K05410] [EC:2.7.11.10]
747565  IRF3; interferon regulatory factor 3 isoform X1 [KO:K05411]
473185  IFNA21; interferon alpha-21 [KO:K05414]
473193  IFNA14; interferon alpha-14 [KO:K05414]
473196  IFNA6; interferon alpha-6 [KO:K05414]
473198  IFNA2; interferon alpha-2 [KO:K05414]
473199  IFNA8; interferon alpha-8 [KO:K05414]
741660  interferon alpha-17 [KO:K05414]
473195  IFNA5; interferon alpha-5 [KO:K05414]
741747  interferon alpha-7 [KO:K05414]
742651  interferon alpha-1/13 [KO:K05414]
741978  interferon alpha-16 [KO:K05414]
744748  interferon alpha-17 [KO:K05414]
473191  interferon alpha-17 [KO:K05414]
473197  interferon alpha-1/13 [KO:K05414]
741797  interferon alpha-4 [KO:K05414]
473183  IFNB1; interferon beta [KO:K05415]
472029  IL17A; interleukin-17A [KO:K05489]
458629  IL17RA; interleukin-17 receptor A isoform X1 [KO:K05164]
460159  IL17RC; interleukin-17 receptor C isoform X2 [KO:K05166]
740567  CXCL1; growth-regulated alpha protein [KO:K05505]
461255  CXCL3; C-X-C motif chemokine 3 [KO:K05505]
469584  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
738331  FAS; tumor necrosis factor receptor superfamily member 6 isoform X1 [KO:K04390]
451389  FADD; FAS-associated death domain protein [KO:K02373]
466934  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A isoform X1 [KO:K03158]
454154  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein isoform X2 [KO:K03171]
746477  CASP8; caspase-8 isoform X9 [KO:K04398] [EC:3.4.22.61]
461669  CASP3; caspase-3 isoform X2 [KO:K02187] [EC:3.4.22.56]
462397  RIPK1; receptor-interacting serine/threonine-protein kinase 1 isoform X1 [KO:K02861] [EC:2.7.11.1]
473550  TAB3; TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 isoform X2 [KO:K12793]
454480  SREBF1; sterol regulatory element-binding protein 1 isoform X2 [KO:K07197]
454986  FASN; fatty acid synthase isoform X1 [KO:K00665] [EC:2.3.1.85]
454602  ACACA; acetyl-CoA carboxylase 1 isoform X6 [KO:K11262] [EC:6.4.1.2 6.3.4.14 2.1.3.15]
450676  SCD; stearoyl-CoA desaturase [KO:K00507] [EC:1.14.19.1]
461211  SCD5; stearoyl-CoA desaturase 5 isoform X1 [KO:K00507] [EC:1.14.19.1]
459036  LPIN1; phosphatidate phosphatase LPIN1 isoform X4 [KO:K15728] [EC:3.1.3.4]
458255  LPIN3; phosphatidate phosphatase LPIN3 isoform X1 [KO:K15728] [EC:3.1.3.4]
455317  LPIN2; phosphatidate phosphatase LPIN2 isoform X1 [KO:K15728] [EC:3.1.3.4]
100316377  MIR217; ptr-miR-217 [KO:K17125]
107966703  SIRT1; NAD-dependent protein deacetylase sirtuin-1 isoform X1 [KO:K11411] [EC:2.3.1.286]
463292  TRA2A; transformer-2 protein homolog alpha isoform X1 [KO:K12897]
460905  TRA2B; transformer-2 protein homolog beta isoform X2 [KO:K12897]
471032  ADIPOQ; adiponectin isoform X2 [KO:K07296]
451742  ADIPOR2; adiponectin receptor protein 2 isoform X1 [KO:K07297]
457635  ADIPOR1; adiponectin receptor protein 1 [KO:K07297]
452320  CAMKK2; calcium/calmodulin-dependent protein kinase kinase 2 isoform X8 [KO:K07359] [EC:2.7.11.17]
741802  PRKAA2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 isoform X1 [KO:K07198] [EC:2.7.11.31]
471564  PRKAA1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform X1 [KO:K07198] [EC:2.7.11.31]
452297  PRKAB1; 5'-AMP-activated protein kinase subunit beta-1 [KO:K07199]
457245  PRKAB2; 5'-AMP-activated protein kinase subunit beta-2 [KO:K07199]
470648  PRKAG3; 5'-AMP-activated protein kinase subunit gamma-3 isoform X1 [KO:K07200]
451872  PRKAG1; 5'-AMP-activated protein kinase subunit gamma-1 isoform X3 [KO:K07200]
463879  PRKAG2; 5'-AMP-activated protein kinase subunit gamma-2 isoform X6 [KO:K07200]
467352  FOXO1; forkhead box protein O1 [KO:K07201]
462921  FOXO3; forkhead box protein O3 isoform X1 [KO:K09408]
461140  PPARGC1A; peroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform X1 [KO:K07202]
458910  PPARA; peroxisome proliferator-activated receptor alpha isoform X1 [KO:K07294]
451382  CPT1A; carnitine O-palmitoyltransferase 1, liver isoform isoform X1 [KO:K08765] [EC:2.3.1.21]
455237  ACADVL; very long-chain specific acyl-CoA dehydrogenase, mitochondrial isoform X1 [KO:K09479] [EC:1.3.8.9]
469356  ACADM; medium-chain specific acyl-CoA dehydrogenase, mitochondrial precursor [KO:K00249] [EC:1.3.8.7]
454895  ACOX1; peroxisomal acyl-coenzyme A oxidase 1 isoform X4 [KO:K00232] [EC:1.3.3.6]
461115  ACOX3; peroxisomal acyl-coenzyme A oxidase 3 isoform X2 [KO:K00232] [EC:1.3.3.6]
736471  FABP1; fatty acid-binding protein, liver [KO:K08750]
744064  alcohol dehydrogenase 1A isoform X1 [KO:K13951] [EC:1.1.1.1]
461396  ADH1B; all-trans-retinol dehydrogenase [NAD(+)] ADH1B [KO:K13951] [EC:1.1.1.1]
744176  alcohol dehydrogenase 1C isoform X2 [KO:K13951] [EC:1.1.1.1]
471257  ADH7; all-trans-retinol dehydrogenase [NAD(+)] ADH7 isoform X1 [KO:K13951] [EC:1.1.1.1]
461394  ADH4; all-trans-retinol dehydrogenase [NAD(+)] ADH4 [KO:K13980] [EC:1.1.1.1]
743928  ADH5; alcohol dehydrogenase class-3 [KO:K00121] [EC:1.1.1.284 1.1.1.1]
100610180  alcohol dehydrogenase class-3-like [KO:K00121] [EC:1.1.1.284 1.1.1.1]
129144434  alcohol dehydrogenase class-3-like [KO:K00121] [EC:1.1.1.284 1.1.1.1]
129144437  alcohol dehydrogenase class-3 [KO:K00121] [EC:1.1.1.284 1.1.1.1]
461395  ADH6; alcohol dehydrogenase 6 isoform X2 [KO:K13952] [EC:1.1.1.1]
464931  ALDH1B1; aldehyde dehydrogenase X, mitochondrial isoform X1 [KO:K00128] [EC:1.2.1.3]
107967644  ALDH2; aldehyde dehydrogenase, mitochondrial isoform X1 [KO:K00128] [EC:1.2.1.3]
462033  ALDH7A1; alpha-aminoadipic semialdehyde dehydrogenase [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]
457478  ALDH9A1; 4-trimethylaminobutyraldehyde dehydrogenase [KO:K00149] [EC:1.2.1.47 1.2.1.3]
450857  CYP2E1; cytochrome P450 2E1 isoform X1 [KO:K07415] [EC:1.14.14.-]
452219  ACACB; acetyl-CoA carboxylase 2 isoform X4 [KO:K01946] [EC:6.4.1.2 6.3.4.14 2.1.3.15]
468127  MLYCD; malonyl-CoA decarboxylase, mitochondrial [KO:K01578] [EC:4.1.1.9]
470253  CPT1B; carnitine O-palmitoyltransferase 1, muscle isoform [KO:K19523] [EC:2.3.1.21]
748258  CPT1C; palmitoyl thioesterase CPT1C isoform X1 [KO:K19524] [EC:2.3.1.21]
735636  NOX4; NADPH oxidase 4 isoform X10 [KO:K21423] [EC:1.6.3.-]
456035  AKT2; RAC-beta serine/threonine-protein kinase isoform X6 [KO:K04456] [EC:2.7.11.1]
740898  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
100609583  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
100616510  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
450183  CTNNB1; catenin beta-1 isoform X1 [KO:K02105]
745839  TCF7; transcription factor 7 isoform X1 [KO:K02620]
744526  TCF7L1; transcription factor 7-like 1 isoform X2 [KO:K04490]
450743  TCF7L2; transcription factor 7-like 2 isoform X2 [KO:K04491]
461425  LEF1; lymphoid enhancer-binding factor 1 isoform X15 [KO:K04492]
747442  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
463023  MAP3K5; mitogen-activated protein kinase kinase kinase 5 isoform X1 [KO:K04426] [EC:2.7.11.25]
455065  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 isoform X4 [KO:K04430] [EC:2.7.12.2]
743199  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X3 [KO:K04431] [EC:2.7.12.2]
450445  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
462336  MAPK9; mitogen-activated protein kinase 9 isoform X2 [KO:K04440] [EC:2.7.11.24]
461358  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
107972404  dual specificity mitogen-activated protein kinase kinase 3 isoform X1 [KO:K04432] [EC:2.7.12.2]
468310  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 isoform X2 [KO:K04433] [EC:2.7.12.2]
450161  MAPK14; mitogen-activated protein kinase 14 [KO:K04441] [EC:2.7.11.24]
462644  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
747077  MAPK12; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
104003820  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
454750  MAP3K14; mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
Compound
C00003  NAD+
C00005  NADPH
C00006  NADP+
C00024  Acetyl-CoA
C00033  Acetate
C00040  Acyl-CoA
C00076  Calcium cation
C00083  Malonyl-CoA
C00084  Acetaldehyde
C00469  Ethanol
C22381  Reactive oxygen species
Reference
PMID:25782093
  Authors
Louvet A, Mathurin P
  Title
Alcoholic liver disease: mechanisms of injury and targeted treatment.
  Journal
Nat Rev Gastroenterol Hepatol 12:231-42 (2015)
DOI:10.1038/nrgastro.2015.35
Reference
PMID:21920463
  Authors
Gao B, Bataller R
  Title
Alcoholic liver disease: pathogenesis and new therapeutic targets.
  Journal
Gastroenterology 141:1572-85 (2011)
DOI:10.1053/j.gastro.2011.09.002
Reference
PMID:28134813
  Authors
Magdaleno F, Blajszczak CC, Nieto N
  Title
Key Events Participating in the Pathogenesis of Alcoholic Liver Disease.
  Journal
Biomolecules 7:E9 (2017)
DOI:10.3390/biom7010009
Reference
PMID:19553649
  Authors
Lucey MR, Mathurin P, Morgan TR
  Title
Alcoholic hepatitis.
  Journal
N Engl J Med 360:2758-69 (2009)
DOI:10.1056/NEJMra0805786
Reference
PMID:26919968
  Authors
Nagy LE, Ding WX, Cresci G, Saikia P, Shah VH
  Title
Linking Pathogenic Mechanisms of Alcoholic Liver Disease With Clinical Phenotypes.
  Journal
Gastroenterology 150:1756-68 (2016)
DOI:10.1053/j.gastro.2016.02.035
Reference
PMID:25009376
  Authors
Fujii H, Kawada N
  Title
Fibrogenesis in alcoholic liver disease.
  Journal
World J Gastroenterol 20:8048-54 (2014)
DOI:10.3748/wjg.v20.i25.8048
Reference
PMID:26755857
  Authors
Kim MS, Ong M, Qu X
  Title
Optimal management for alcoholic liver disease: Conventional medications, natural therapy or combination?
  Journal
World J Gastroenterol 22:8-23 (2016)
DOI:10.3748/wjg.v22.i1.8
Reference
PMID:15194557
  Authors
You M, Crabb DW
  Title
Recent advances in alcoholic liver disease II. Minireview: molecular mechanisms of alcoholic fatty liver.
  Journal
Am J Physiol Gastrointest Liver Physiol 287:G1-6 (2004)
DOI:10.1152/ajpgi.00056.2004
Reference
PMID:26695748
  Authors
Nagy LE
  Title
The Role of Innate Immunity in Alcoholic Liver Disease.
  Journal
Alcohol Res 37:237-50 (2015)
Reference
PMID:21252049
  Authors
Gao B, Seki E, Brenner DA, Friedman S, Cohen JI, Nagy L, Szabo G, Zakhari S
  Title
Innate immunity in alcoholic liver disease.
  Journal
Am J Physiol Gastrointest Liver Physiol 300:G516-25 (2011)
DOI:10.1152/ajpgi.00537.2010
Reference
PMID:22524187
  Authors
Wang HJ, Gao B, Zakhari S, Nagy LE
  Title
Inflammation in alcoholic liver disease.
  Journal
Annu Rev Nutr 32:343-68 (2012)
DOI:10.1146/annurev-nutr-072610-145138
Reference
PMID:29597356
  Authors
McCullough RL, McMullen MR, Sheehan MM, Poulsen KL, Roychowdhury S, Chiang DJ, Pritchard MT, Caballeria J, Nagy LE
  Title
Complement Factor D protects mice from ethanol-induced inflammation and liver injury.
  Journal
Am J Physiol Gastrointest Liver Physiol 315:G66-G79 (2018)
DOI:10.1152/ajpgi.00334.2017
Reference
PMID:24385684
  Authors
Kawaratani H, Tsujimoto T, Douhara A, Takaya H, Moriya K, Namisaki T, Noguchi R, Yoshiji H, Fujimoto M, Fukui H
  Title
The effect of inflammatory cytokines in alcoholic liver disease.
  Journal
Mediators Inflamm 2013:495156 (2013)
DOI:10.1155/2013/495156
Reference
PMID:20238398
  Authors
Szabo G, Bala S
  Title
Alcoholic liver disease and the gut-liver axis.
  Journal
World J Gastroenterol 16:1321-9 (2010)
DOI:10.3748/wjg.v16.i11.1321
Reference
PMID:28627645
  Authors
Kawaratani H, Moriya K, Namisaki T, Uejima M, Kitade M, Takeda K, Okura Y, Kaji K, Takaya H, Nishimura N, Sato S, Sawada Y, Seki K, Kubo T, Mitoro A, Yamao J, Yoshiji H
  Title
Therapeutic strategies for alcoholic liver disease: Focusing on inflammation and fibrosis (Review).
  Journal
Int J Mol Med 40:263-270 (2017)
DOI:10.3892/ijmm.2017.3015
Reference
PMID:23855294
  Authors
Roh YS, Seki E
  Title
Toll-like receptors in alcoholic liver disease, non-alcoholic steatohepatitis and carcinogenesis.
  Journal
J Gastroenterol Hepatol 28 Suppl 1:38-42 (2013)
DOI:10.1111/jgh.12019
Reference
PMID:18709650
  Authors
Rogers CQ, Ajmo JM, You M
  Title
Adiponectin and alcoholic fatty liver disease.
  Journal
IUBMB Life 60:790-7 (2008)
DOI:10.1002/iub.124
Reference
PMID:26278388
  Authors
You M, Jogasuria A, Lee K, Wu J, Zhang Y, Lee YK, Sadana P
  Title
Signal Transduction Mechanisms of Alcoholic Fatty Liver Disease: Emer ging Role of Lipin-1.
  Journal
Curr Mol Pharmacol 10:226-236 (2017)
DOI:10.2174/1874467208666150817112109
Reference
PMID:26005675
  Authors
You M, Jogasuria A, Taylor C, Wu J
  Title
Sirtuin 1 signaling and alcoholic fatty liver disease.
  Journal
Hepatobiliary Surg Nutr 4:88-100 (2015)
DOI:10.3978/j.issn.2304-3881.2014.12.06
Reference
PMID:33162823
  Authors
Ren R, Wang Z, Wu M, Wang H
  Title
Emerging Roles of SIRT1 in Alcoholic Liver Disease.
  Journal
Int J Biol Sci 16:3174-3183 (2020)
DOI:10.7150/ijbs.49535
Reference
PMID:19032584
  Authors
Purohit V, Gao B, Song BJ
  Title
Molecular mechanisms of alcoholic fatty liver.
  Journal
Alcohol Clin Exp Res 33:191-205 (2009)
DOI:10.1111/j.1530-0277.2008.00827.x
Reference
PMID:34071962
  Authors
Hyun J, Han J, Lee C, Yoon M, Jung Y
  Title
Pathophysiological Aspects of Alcohol Metabolism in the Liver.
  Journal
Int J Mol Sci 22:5717 (2021)
DOI:10.3390/ijms22115717
Reference
PMID:24297186
  Authors
Combs TP, Marliss EB
  Title
Adiponectin signaling in the liver.
  Journal
Rev Endocr Metab Disord 15:137-47 (2014)
DOI:10.1007/s11154-013-9280-6
Reference
PMID:25548474
  Authors
Ceni E, Mello T, Galli A
  Title
Pathogenesis of alcoholic liver disease: role of oxidative metabolism.
  Journal
World J Gastroenterol 20:17756-72 (2014)
DOI:10.3748/wjg.v20.i47.17756
Reference
PMID:31159489
  Authors
Kong LZ, Chandimali N, Han YH, Lee DH, Kim JS, Kim SU, Kim TD, Jeong DK, Sun HN, Lee DS, Kwon T
  Title
Pathogenesis, Early Diagnosis, and Therapeutic Management of Alcoholic Liver Disease.
  Journal
Int J Mol Sci 20:E2712 (2019)
DOI:10.3390/ijms20112712
Reference
PMID:31214376
  Authors
Ohashi K, Pimienta M, Seki E
  Title
Alcoholic liver disease: A current molecular and clinical perspective.
  Journal
Liver Res 2:161-172 (2018)
DOI:10.1016/j.livres.2018.11.002
Reference
PMID:30658725
  Authors
You M, Arteel GE
  Title
Effect of ethanol on lipid metabolism.
  Journal
J Hepatol 70:237-248 (2019)
DOI:10.1016/j.jhep.2018.10.037
Reference
PMID:25595739
  Authors
Bi L, Jiang Z, Zhou J
  Title
The role of lipin-1 in the pathogenesis of alcoholic fatty liver.
  Journal
Alcohol Alcohol 50:146-51 (2015)
DOI:10.1093/alcalc/agu102
Reference
PMID:31263795
  Authors
Ali H, Assiri MA, Shearn CT, Fritz KS
  Title
Lipid peroxidation derived reactive aldehydes in alcoholic liver disease.
  Journal
Curr Opin Toxicol 13:110-117 (2019)
DOI:10.1016/j.cotox.2018.10.003
Reference
PMID:24262277
  Authors
Yin H, Hu M, Liang X, Ajmo JM, Li X, Bataller R, Odena G, Stevens SM Jr, You M
  Title
Deletion of SIRT1 from hepatocytes in mice disrupts lipin-1 signaling and aggravates alcoholic fatty liver.
  Journal
Gastroenterology 146:801-11 (2014)
DOI:10.1053/j.gastro.2013.11.008
Reference
PMID:22110053
  Authors
Stickel F, Hampe J
  Title
Genetic determinants of alcoholic liver disease.
  Journal
Gut 61:150-9 (2012)
DOI:10.1136/gutjnl-2011-301239
Reference
PMID:29336467
  Authors
Yang CF, Zhong YJ, Ma Z, Li L, Shi L, Chen L, Li C, Wu D, Chen Q, Li YW
  Title
NOX4/ROS mediate ethanolinduced apoptosis via MAPK signal pathway in L02 cells.
  Journal
Int J Mol Med 41:2306-2316 (2018)
DOI:10.3892/ijmm.2018.3390
Related
pathway
ptr00061  Fatty acid biosynthesis
ptr00071  Fatty acid degradation
ptr01040  Biosynthesis of unsaturated fatty acids
ptr03040  Spliceosome
ptr04010  MAPK signaling pathway
ptr04064  NF-kappa B signaling pathway
ptr04152  AMPK signaling pathway
ptr04210  Apoptosis
ptr04310  Wnt signaling pathway
ptr04610  Complement and coagulation cascades
ptr04620  Toll-like receptor signaling pathway
ptr04657  IL-17 signaling pathway
ptr04668  TNF signaling pathway
ptr04920  Adipocytokine signaling pathway
ptr05034  Alcoholism
ptr05225  Hepatocellular carcinoma
KO pathway
ko04936   
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