Entry
Name
MicroRNAs in cancer - Ursus arctos horribilis (North American brown bear)
Description
MicroRNA (miRNA) is a cluster of small non-encoding RNA molecules of 21 - 23 nucleotides in length, which controls gene expression post-transcriptionally either via the degradation of target mRNAs or the inhibition of protein translation. Using high-throughput profiling, dysregulation of miRNAs has been widely observed in different stages of cancer. The upregulation (overexpression) of specific miRNAs could lead to the repression of tumor suppressor gene expression, and conversely the downregulation of specific miRNAs could result in an increase of oncogene expression; both these situations induce subsequent malignant effects on cell proliferation, differentiation, and apoptosis that lead to tumor growth and progress. The miRNA signatures of cancer observed in various studies differ significantly. These inconsistencies occur due to the differences in the study populations and methodologies used. This pathway map shows the summarized results from various studies in 9 cancers, each of which is presented in a review article.
Class
Human Diseases; Cancer: overview
BRITE hierarchy
Pathway map
Ortholog table
Organism
Ursus arctos horribilis (North American brown bear) [GN:
uah ]
Gene
113246198 MCL1; induced myeloid leukemia cell differentiation protein Mcl-1 [KO:K02539 ]
113244240 ZEB1; zinc finger E-box-binding homeobox 1 isoform X1 [KO:K09299 ]
113263391 ZEB2; zinc finger E-box-binding homeobox 2 isoform X1 [KO:K23560 ]
113256910 RASSF1; ras association domain-containing protein 1 isoform X1 [KO:K09850 ]
113251221 SLC7A1; high affinity cationic amino acid transporter 1 [KO:K13863 ]
113265422 STAT3; signal transducer and activator of transcription 3 isoform X1 [KO:K04692 ]
113256705 PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649 ]
113254730 PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649 ]
113255266 PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649 ]
113254799 PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922 ] [EC:2.7.1.153 ]
113270537 PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922 ] [EC:2.7.1.153 ]
113253989 PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922 ] [EC:2.7.1.153 ]
113269808 HNRNPK; heterogeneous nuclear ribonucleoprotein K isoform X1 [KO:K12886 ]
113260457 RECK; reversion-inducing cysteine-rich protein with Kazal motifs isoform X1 [KO:K17461 ]
113248714 NOTCH3; neurogenic locus notch homolog protein 3 isoform X1 [KO:K20995 ]
113243767 NOTCH4; neurogenic locus notch homolog protein 4 isoform X1 [KO:K20996 ]
113265595 IGF2BP1; LOW QUALITY PROTEIN: insulin-like growth factor 2 mRNA-binding protein 1 [KO:K17391 ]
113263101 NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580 ]
113258609 PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116 ] [EC:3.1.4.11 ]
113241764 PDGFB; platelet-derived growth factor subunit B isoform X1 [KO:K17386 ]
113264709 MARCKS; myristoylated alanine-rich C-kinase substrate [KO:K12561 ]
Reference
Authors
Lee YS, Dutta A
Title
MicroRNAs in cancer.
Journal
Reference
Authors
Babashah S, Soleimani M
Title
The oncogenic and tumour suppressive roles of microRNAs in cancer and apoptosis.
Journal
Reference
Authors
Garzon R, Calin GA, Croce CM
Title
MicroRNAs in Cancer.
Journal
Reference
Authors
Chen PS, Su JL, Hung MC
Title
Dysregulation of microRNAs in cancer.
Journal
Reference
Authors
Ling H, Zhang W, Calin GA
Title
Principles of microRNA involvement in human cancers.
Journal
Reference
Authors
Iorio MV, Croce CM
Title
MicroRNA dysregulation in cancer: diagnostics, monitoring and therapeutics. A comprehensive review.
Journal
Reference
Authors
Sayed D, Abdellatif M
Title
MicroRNAs in development and disease.
Journal
Reference
Authors
Wang Q, Wang S, Wang H, Li P, Ma Z
Title
MicroRNAs: novel biomarkers for lung cancer diagnosis, prediction and treatment.
Journal
Reference
Authors
Song JH, Meltzer SJ
Title
MicroRNAs in pathogenesis, diagnosis, and treatment of gastroesophageal cancers.
Journal
Reference
Authors
Chu Y, Zhu H, Lv L, Zhou Y, Huo J
Title
MiRNA s in oesophageal squamous cancer.
Journal
Neth J Med 71:69-75 (2013)
Reference
Authors
Kan T, Meltzer SJ
Title
MicroRNAs in Barrett's esophagus and esophageal adenocarcinoma.
Journal
Reference
Authors
Smith CM, Watson DI, Michael MZ, Hussey DJ
Title
MicroRNAs, development of Barrett's esophagus, and progression to esophageal adenocarcinoma.
Journal
Reference
Authors
Song S, Ajani JA
Title
The role of microRNAs in cancers of the upper gastrointestinal tract.
Journal
Reference
Authors
Liu WH, Yeh SH, Chen PJ
Title
Role of microRNAs in hepatitis B virus replication and pathogenesis.
Journal
Reference
Authors
Hrasovec S, Glavac D
Title
MicroRNAs as Novel Biomarkers in Colorectal Cancer.
Journal
Reference
Authors
Liu H
Title
MicroRNAs in breast cancer initiation and progression.
Journal
Reference
Authors
Li SD, Zhang JR, Wang YQ, Wan XP
Title
The role of microRNAs in ovarian cancer initiation and progression.
Journal
Reference
Authors
Zabolotneva AA, Zhavoronkov A, Garazha AV, Roumiantsev SA, Buzdin AA
Title
Characteristic patterns of microRNA expression in human bladder cancer.
Journal
Reference
Authors
Saini S, Majid S, Dahiya R
Title
Diet, microRNAs and prostate cancer.
Journal
Related pathway
KO pathway
LinkDB
All DBs