KEGG   PATHWAY: umr04072
Entry
umr04072                    Pathway                                
Name
Phospholipase D signaling pathway - Ursus maritimus (polar bear)
Description
Phospholipase D (PLD) is an essential enzyme responsible for the production of the lipid second messenger phosphatidic acid (PA), which is involved in fundamental cellular processes, including membrane trafficking, actin cytoskeleton remodeling, cell proliferation and cell survival. PLD activity can be stimulated by a large number of cell surface receptors and is elaborately regulated by intracellular factors, including protein kinase C isoforms, small GTPases of the ARF, Rho and Ras families and the phosphoinositide, phosphatidylinositol 4,5-bisphosphate (PIP2). The PLD-produced PA activates signaling proteins and acts as a node within the membrane to which signaling proteins translocate. Several signaling proteins, including Raf-1 and mTOR, directly bind PA to mediate translocation or activation, respectively.
Class
Environmental Information Processing; Signal transduction
Pathway map
umr04072  Phospholipase D signaling pathway
umr04072

Organism
Ursus maritimus (polar bear) [GN:umr]
Gene
103661742  EGF; pro-epidermal growth factor isoform X2 [KO:K04357]
103670054  PDGFA; platelet-derived growth factor subunit A [KO:K04359]
103676520  PDGFB; platelet-derived growth factor subunit B isoform X1 [KO:K17386]
103662543  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
103658054  PDGFC; platelet-derived growth factor C isoform X2 [KO:K05450]
103660144  KITLG; LOW QUALITY PROTEIN: kit ligand [KO:K05461]
121099769  INS; insulin [KO:K04526]
103674660  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
103672737  PDGFRA; platelet-derived growth factor receptor alpha isoform X1 [KO:K04363] [EC:2.7.10.1]
103664600  PDGFRB; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
103672804  KIT; mast/stem cell growth factor receptor Kit isoform X1 [KO:K05091] [EC:2.7.10.1]
103676308  INSR; insulin receptor [KO:K04527] [EC:2.7.10.1]
103665736  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
103658080  GAB1; GRB2-associated-binding protein 1 isoform X1 [KO:K09593]
103678081  GAB2; GRB2-associated-binding protein 2 isoform X3 [KO:K08091]
103668383  SHC1; SHC-transforming protein 1 isoform X2 [KO:K06279]
103681753  SHC2; SHC-transforming protein 2 isoform X1 [KO:K17447]
103663185  SHC3; SHC-transforming protein 3 isoform X1 [KO:K17448]
103676722  SHC4; SHC-transforming protein 4 [KO:K17449]
103661289  PTPN11; tyrosine-protein phosphatase non-receptor type 11 isoform X1 [KO:K07293] [EC:3.1.3.48]
103682087  tyrosine-protein phosphatase non-receptor type 11-like [KO:K07293] [EC:3.1.3.48]
103671891  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
103665409  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
103669173  LOW QUALITY PROTEIN: GTPase HRas-like [KO:K02833]
103671035  HRAS; GTPase HRas isoform X3 [KO:K02833]
103665244  KRAS; GTPase KRas isoform X1 [KO:K07827]
103669422  NRAS; GTPase NRas [KO:K07828]
103678665  MRAS; ras-related protein M-Ras isoform X1 [KO:K07831]
103657130  RRAS; ras-related protein R-Ras isoform X2 [KO:K07829]
103682372  RRAS2; LOW QUALITY PROTEIN: ras-related protein R-Ras2 [KO:K07830]
103670397  RALGDS; ral guanine nucleotide dissociation stimulator isoform X1 [KO:K08732]
103674594  RALA; ras-related protein Ral-A [KO:K07834]
103658585  RALB; ras-related protein Ral-B [KO:K07835]
103678592  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
103666874  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
103676125  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
103675162  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
103663617  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X3 [KO:K02649]
103670766  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
103666688  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
103661038  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
103676878  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
103670250  TSC1; hamartin [KO:K07206]
103668779  TSC2; tuberin isoform X1 [KO:K07207]
103660943  RHEB; GTP-binding protein Rheb isoform X1 [KO:K07208]
103666660  MTOR; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
103674825  RHOA; transforming protein RhoA [KO:K04513]
103678859  ARF1; ADP-ribosylation factor 1 [KO:K07937]
103665610  ADP-ribosylation factor 2 [KO:K07937]
103665472  ARF6; ADP-ribosylation factor 6 [KO:K07941]
103669754  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116] [EC:3.1.4.11]
103662093  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 isoform X1 [KO:K05859] [EC:3.1.4.11]
103672060  FCER1A; high affinity immunoglobulin epsilon receptor subunit alpha [KO:K08089]
103661310  high affinity immunoglobulin epsilon receptor subunit beta [KO:K08090]
103661314  high affinity immunoglobulin epsilon receptor subunit beta [KO:K08090]
103661312  membrane-spanning 4-domains subfamily A member 3 isoform X1 [KO:K08090]
103672015  FCER1G; high affinity immunoglobulin epsilon receptor subunit gamma [KO:K07983]
103676988  FYN; tyrosine-protein kinase Fyn isoform X1 [KO:K05703] [EC:2.7.10.2]
103663192  SYK; tyrosine-protein kinase SYK isoform X1 [KO:K05855] [EC:2.7.10.2]
103665907  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
103660447  phospholipase D2 isoform X1 [KO:K01115] [EC:3.1.4.4]
103676145  PLD1; phospholipase D1 [KO:K01115] [EC:3.1.4.4]
103668635  PLA2G4A; cytosolic phospholipase A2 isoform X1 [KO:K16342] [EC:3.1.1.4]
103673432  PLA2G4E; cytosolic phospholipase A2 epsilon [KO:K16342] [EC:3.1.1.4]
103673531  PLA2G4F; cytosolic phospholipase A2 zeta [KO:K16342] [EC:3.1.1.4]
103673532  PLA2G4D; cytosolic phospholipase A2 delta [KO:K16342] [EC:3.1.1.4]
103682278  AGPAT1; 1-acyl-sn-glycerol-3-phosphate acyltransferase alpha isoform X2 [KO:K13509] [EC:2.3.1.51]
103675286  AGPAT2; 1-acyl-sn-glycerol-3-phosphate acyltransferase beta isoform X1 [KO:K13509] [EC:2.3.1.51]
103660824  AGPAT4; 1-acyl-sn-glycerol-3-phosphate acyltransferase delta [KO:K13523] [EC:2.3.1.51 2.3.1.-]
103680700  AGPAT3; 1-acyl-sn-glycerol-3-phosphate acyltransferase gamma [KO:K13523] [EC:2.3.1.51 2.3.1.-]
103676939  AGPAT5; 1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon [KO:K19007] [EC:2.3.1.51]
103657238  SPHK2; sphingosine kinase 2 isoform X1 [KO:K04718] [EC:2.7.1.91]
103665951  SPHK1; sphingosine kinase 1 isoform X1 [KO:K04718] [EC:2.7.1.91]
103669540  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
103679064  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
103681834  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
103669286  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
103657827  MAPK3; mitogen-activated protein kinase 3 isoform X1 [KO:K04371] [EC:2.7.11.24]
103681825  PIP5K1C; phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform X1 [KO:K00889] [EC:2.7.1.68]
103663244  PIP5K1B; phosphatidylinositol 4-phosphate 5-kinase type-1 beta [KO:K00889] [EC:2.7.1.68]
103667518  PIP5K1A; phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X1 [KO:K00889] [EC:2.7.1.68]
103676883  DGKQ; diacylglycerol kinase theta [KO:K00901] [EC:2.7.1.107]
103682485  DGKA; diacylglycerol kinase alpha isoform X2 [KO:K00901] [EC:2.7.1.107]
103658830  DGKB; diacylglycerol kinase beta isoform X1 [KO:K00901] [EC:2.7.1.107]
103662659  DGKD; diacylglycerol kinase delta isoform X1 [KO:K00901] [EC:2.7.1.107]
103676060  DGKG; diacylglycerol kinase gamma isoform X1 [KO:K00901] [EC:2.7.1.107]
103677563  DGKH; diacylglycerol kinase eta isoform X1 [KO:K00901] [EC:2.7.1.107]
103667474  DGKE; diacylglycerol kinase epsilon [KO:K00901] [EC:2.7.1.107]
103669115  DGKI; LOW QUALITY PROTEIN: diacylglycerol kinase iota [KO:K00901] [EC:2.7.1.107]
103667275  DGKK; diacylglycerol kinase kappa [KO:K00901] [EC:2.7.1.107]
103672392  DGKZ; diacylglycerol kinase zeta isoform X1 [KO:K00901] [EC:2.7.1.107]
103681620  PLPP2; phospholipid phosphatase 2 [KO:K01080] [EC:3.1.3.4]
103663676  PLPP1; phospholipid phosphatase 1 isoform X1 [KO:K01080] [EC:3.1.3.4]
103670677  PLPP3; phospholipid phosphatase 3 [KO:K01080] [EC:3.1.3.4]
103672390  F2; prothrombin [KO:K01313] [EC:3.4.21.5]
103661870  AGT; angiotensinogen [KO:K09821]
103674521  vasopressin-neurophysin 2-copeptin [KO:K05242]
103665307  CXCL8; interleukin-8 [KO:K10030]
103678133  AGTR1; type-1 angiotensin II receptor [KO:K04166]
103666935  GRM1; LOW QUALITY PROTEIN: metabotropic glutamate receptor 1 [KO:K04603]
103674782  GRM2; metabotropic glutamate receptor 2 isoform X1 [KO:K04605]
103658785  GRM3; metabotropic glutamate receptor 3 [KO:K04606]
103665551  GRM4; metabotropic glutamate receptor 4 [KO:K04607]
103675379  GRM5; LOW QUALITY PROTEIN: metabotropic glutamate receptor 5 [KO:K04604]
103680010  GRM6; metabotropic glutamate receptor 6 [KO:K04608]
103669589  GRM7; metabotropic glutamate receptor 7 [KO:K04609]
103676623  metabotropic glutamate receptor 8 isoform X1 [KO:K04610]
103656824  AVPR1A; vasopressin V1a receptor [KO:K04226]
103671018  AVPR1B; vasopressin V1b receptor [KO:K04227]
103680475  LOW QUALITY PROTEIN: vasopressin V1b receptor-like [KO:K04227]
103680927  LOW QUALITY PROTEIN: vasopressin V1b receptor-like [KO:K04227]
103680928  vasopressin V1b receptor-like [KO:K04227]
121102044  AVPR2; vasopressin V2 receptor [KO:K04228]
103678568  LPAR1; LOW QUALITY PROTEIN: lysophosphatidic acid receptor 1 [KO:K04289]
103675138  LPAR2; lysophosphatidic acid receptor 2 [KO:K04291]
103662965  LPAR3; lysophosphatidic acid receptor 3 [KO:K04294]
103675824  LPAR4; lysophosphatidic acid receptor 4 [KO:K04275]
103656231  LPAR5; lysophosphatidic acid receptor 5 [KO:K08390]
103677601  LPAR6; lysophosphatidic acid receptor 6 [KO:K04273]
103662981  PTGFR; prostaglandin F2-alpha receptor [KO:K04262]
103662893  CXCR1; C-X-C chemokine receptor type 1 [KO:K04175]
103662772  C-X-C chemokine receptor type 2 [KO:K05050]
103673552  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11]
103674425  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
103674426  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 [KO:K05858] [EC:3.1.4.11]
103679549  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
121099746  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11]
103669942  GNA12; guanine nucleotide-binding protein subunit alpha-12 [KO:K04346]
103675966  PTK2B; protein-tyrosine kinase 2-beta isoform X1 [KO:K05871] [EC:2.7.10.2]
103665670  GNA13; guanine nucleotide-binding protein subunit alpha-13 [KO:K04639]
103674633  PIK3CG; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform isoform X1 [KO:K21289] [EC:2.7.1.153]
103660497  PIK3R5; phosphoinositide 3-kinase regulatory subunit 5 [KO:K21290]
103660496  PIK3R6; phosphoinositide 3-kinase regulatory subunit 6 [KO:K21290]
103657093  CYTH2; cytohesin-2 [KO:K18441]
103676404  CYTH4; cytohesin-4 [KO:K18441]
103665788  CYTH1; cytohesin-1 isoform X3 [KO:K18441]
103669968  CYTH3; cytohesin-3 [KO:K18441]
103670935  LOW QUALITY PROTEIN: guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas [KO:K04632]
103670936  neuroendocrine secretory protein 55 [KO:K04632]
103674675  ADCY1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
103679250  ADCY2; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
103671685  ADCY3; adenylate cyclase type 3 [KO:K08043] [EC:4.6.1.1]
103679331  ADCY4; adenylate cyclase type 4 isoform X2 [KO:K08044] [EC:4.6.1.1]
103678826  ADCY5; adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
103675618  ADCY6; adenylate cyclase type 6 [KO:K08046] [EC:4.6.1.1]
103673916  ADCY7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
103661704  ADCY8; adenylate cyclase type 8 [KO:K08048] [EC:4.6.1.1]
103668547  ADCY9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
103675595  RAPGEF3; rap guanine nucleotide exchange factor 3 [KO:K08014]
103659569  RAPGEF4; rap guanine nucleotide exchange factor 4 [KO:K04351]
103670446  DNM1; dynamin-1 isoform X1 [KO:K01528] [EC:3.6.5.5]
103669226  DNM3; dynamin-3 isoform X1 [KO:K01528] [EC:3.6.5.5]
103678718  DNM2; dynamin-2 isoform X1 [KO:K23484] [EC:3.6.5.5]
Compound
C00025  L-Glutamate
C00076  Calcium cation
C00165  Diacylglycerol
C00416  Phosphatidate
C00575  3',5'-Cyclic AMP
C00639  Prostaglandin F2alpha
C00681  1-Acyl-sn-glycerol 3-phosphate
C01245  D-myo-Inositol 1,4,5-trisphosphate
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C06124  Sphingosine 1-phosphate
Reference
PMID:17245604
  Authors
Oude Weernink PA, Lopez de Jesus M, Schmidt M
  Title
Phospholipase D signaling: orchestration by PIP2 and small GTPases.
  Journal
Naunyn Schmiedebergs Arch Pharmacol 374:399-411 (2007)
DOI:10.1007/s00210-007-0131-4
Reference
PMID:21936578
  Authors
Selvy PE, Lavieri RR, Lindsley CW, Brown HA
  Title
Phospholipase D: enzymology, functionality, and chemical modulation.
  Journal
Chem Rev 111:6064-119 (2011)
DOI:10.1021/cr200296t
Reference
PMID:24995811
  Authors
Brandenburg LO, Pufe T, Koch T
  Title
Role of phospholipase d in g-protein coupled receptor function.
  Journal
Membranes (Basel) 4:302-18 (2014)
DOI:10.3390/membranes4030302
Reference
PMID:17054901
  Authors
Oude Weernink PA, Han L, Jakobs KH, Schmidt M
  Title
Dynamic phospholipid signaling by G protein-coupled receptors.
  Journal
Biochim Biophys Acta 1768:888-900 (2007)
DOI:10.1016/j.bbamem.2006.09.012
Reference
PMID:24990952
  Authors
Foster DA, Salloum D, Menon D, Frias MA
  Title
Phospholipase D and the maintenance of phosphatidic acid levels for regulation of mammalian target of rapamycin (mTOR).
  Journal
J Biol Chem 289:22583-8 (2014)
DOI:10.1074/jbc.R114.566091
Reference
PMID:16143829
  Authors
Jenkins GM, Frohman MA
  Title
Phospholipase D: a lipid centric review.
  Journal
Cell Mol Life Sci 62:2305-16 (2005)
DOI:10.1007/s00018-005-5195-z
Reference
PMID:19815110
  Authors
Metcalfe DD, Peavy RD, Gilfillan AM
  Title
Mechanisms of mast cell signaling in anaphylaxis.
  Journal
J Allergy Clin Immunol 124:639-46; quiz 647-8 (2009)
DOI:10.1016/j.jaci.2009.08.035
Reference
PMID:18936782
  Authors
Kalesnikoff J, Galli SJ
  Title
New developments in mast cell biology.
  Journal
Nat Immunol 9:1215-23 (2008)
DOI:10.1038/ni.f.216
Reference
PMID:12217395
  Authors
Cockcroft S, Way G, O'Luanaigh N, Pardo R, Sarri E, Fensome A
  Title
Signalling role for ARF and phospholipase D in mast cell exocytosis stimulated by crosslinking of the high affinity FcepsilonR1 receptor.
  Journal
Mol Immunol 38:1277-82 (2002)
DOI:10.1016/S0161-5890(02)00075-5
Reference
PMID:19410013
  Authors
Lee CS, Kim KL, Jang JH, Choi YS, Suh PG, Ryu SH
  Title
The roles of phospholipase D in EGFR signaling.
  Journal
Biochim Biophys Acta 1791:862-8 (2009)
DOI:10.1016/j.bbalip.2009.04.007
Reference
PMID:16622417
  Authors
Lee CS, Kim IS, Park JB, Lee MN, Lee HY, Suh PG, Ryu SH
  Title
The phox homology domain of phospholipase D activates dynamin GTPase activity and accelerates EGFR endocytosis.
  Journal
Nat Cell Biol 8:477-84 (2006)
DOI:10.1038/ncb1401
Reference
PMID:14769825
  Authors
Kam Y, Exton JH
  Title
Role of phospholipase D1 in the regulation of mTOR activity by lysophosphatidic acid.
  Journal
FASEB J 18:311-9 (2004)
DOI:10.1096/fj.03-0731com
Reference
PMID:9310372
  Authors
Kozawa O, Blume-Jensen P, Heldin CH, Ronnstrand L
  Title
Involvement of phosphatidylinositol 3'-kinase in stem-cell-factor-induced phospholipase D activation and arachidonic acid release.
  Journal
Eur J Biochem 248:149-55 (1997)
DOI:10.1111/j.1432-1033.1997.00149.x
Reference
PMID:11042115
  Authors
Slaaby R, Du G, Altshuller YM, Frohman MA, Seedorf K
  Title
Insulin-induced phospholipase D1 and phospholipase D2 activity in human embryonic kidney-293 cells mediated by the phospholipase C gamma and protein kinase C alpha signalling cascade.
  Journal
Biochem J 351 Pt 3:613-9 (2000)
DOI:10.1042/bj3510613
Reference
PMID:11991733
  Authors
Fahimi-Vahid M, Gosau N, Michalek C, Han L, Jakobs KH, Schmidt M, Roberts N, Avkiran M, Wieland T
  Title
Distinct signaling pathways mediate cardiomyocyte phospholipase D stimulation by endothelin-1 and thrombin.
  Journal
J Mol Cell Cardiol 34:441-53 (2002)
DOI:10.1006/jmcc.2002.1525
Reference
PMID:10666319
  Authors
Freeman EJ
  Title
The Ang II-induced growth of vascular smooth muscle cells involves a phospholipase D-mediated signaling mechanism.
  Journal
Arch Biochem Biophys 374:363-70 (2000)
DOI:10.1006/abbi.1999.1608
Reference
PMID:9119890
  Authors
Naro F, Donchenko V, Minotti S, Zolla L, Molinaro M, Adamo S
  Title
Role of phospholipase C and D signalling pathways in vasopressin-dependent myogenic differentiation.
  Journal
J Cell Physiol 171:34-42 (1997)
DOI:10.1002/(SICI)1097-4652(199704)171:1<34::AID-JCP5>3.0.CO;2-I
Reference
PMID:10807766
  Authors
Murdoch C, Finn A
  Title
Chemokine receptors and their role in inflammation and infectious diseases.
  Journal
Blood 95:3032-43 (2000)
Reference
PMID:8135758
  Authors
Sugiyama T, Sakai T, Nozawa Y, Oka N
  Title
Prostaglandin F2 alpha-stimulated phospholipase D activation in osteoblast-like MC3T3-E1 cells: involvement in sustained 1,2-diacylglycerol production.
  Journal
Biochem J 298 ( Pt 2):479-84 (1994)
DOI:10.1042/bj2980479
Reference
PMID:17210675
  Authors
Foster DA
  Title
Regulation of mTOR by phosphatidic acid?
  Journal
Cancer Res 67:1-4 (2007)
DOI:10.1158/0008-5472.CAN-06-3016
Reference
PMID:15310762
  Authors
Delon C, Manifava M, Wood E, Thompson D, Krugmann S, Pyne S, Ktistakis NT
  Title
Sphingosine kinase 1 is an intracellular effector of phosphatidic acid.
  Journal
J Biol Chem 279:44763-74 (2004)
DOI:10.1074/jbc.M405771200
Reference
PMID:23076158
  Authors
Park JB, Lee CS, Jang JH, Ghim J, Kim YJ, You S, Hwang D, Suh PG, Ryu SH
  Title
Phospholipase signalling networks in cancer.
  Journal
Nat Rev Cancer 12:782-92 (2012)
DOI:10.1038/nrc3379
Reference
PMID:19264150
  Authors
Foster DA
  Title
Phosphatidic acid signaling to mTOR: signals for the survival of human cancer cells.
  Journal
Biochim Biophys Acta 1791:949-55 (2009)
DOI:10.1016/j.bbalip.2009.02.009
Related
pathway
umr00561  Glycerolipid metabolism
umr04010  MAPK signaling pathway
umr04014  Ras signaling pathway
umr04020  Calcium signaling pathway
umr04024  cAMP signaling pathway
umr04071  Sphingolipid signaling pathway
umr04144  Endocytosis
umr04150  mTOR signaling pathway
umr04151  PI3K-Akt signaling pathway
umr04664  Fc epsilon RI signaling pathway
KO pathway
ko04072   
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