KEGG   PATHWAY: dre04020
Entry
dre04020                    Pathway                                
Name
Calcium signaling pathway - Danio rerio (zebrafish)
Description
Ca2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this external source of signal Ca2+ by activating various entry channels with widely different properties. The voltage-operated channels (VOCs) are found in excitable cells and generate the rapid Ca2+ fluxes that control fast cellular processes. There are many other Ca2+-entry channels, such as the receptor-operated channels (ROCs), for example the NMDA (N-methyl-D-aspartate) receptors (NMDARs) that respond to glutamate. There also are second-messenger-operated channels (SMOCs) and store-operated channels (SOCs).
The other principal source of Ca2+ for signalling is the internal stores that are located primarily in the endoplasmic/sarcoplasmic reticulum (ER/SR), in which inositol-1,4,5-trisphosphate receptors (IP3Rs) or ryanodine receptors (RYRs) regulate the release of Ca2+. The principal activator of these channels is Ca2+ itself and this process of Ca2+-induced Ca2+ release is central to the mechanism of Ca2+ signalling. Various second messengers or modulators also control the release of Ca2+. IP3, which is generated by pathways using different isoforms of phospholipase C (PLCbeta, delta, epsilon, gamma and zeta), regulates the IP3Rs. Cyclic ADP-ribose (cADPR) releases Ca2+ via RYRs. Nicotinic acid adenine dinucleotide phosphate (NAADP) may activate a distinct Ca2+ release mechanism on separate acidic Ca2+ stores. Ca2+ release via the NAADP-sensitive mechanism may also feedback onto either RYRs or IP3Rs. cADPR and NAADP are generated by CD38. This enzyme might be sensitive to the cellular metabolism, as ATP and NADH inhibit it.
The influx of Ca2+ from the environment or release from internal stores causes a very rapid and dramatic increase in cytoplasmic calcium concentration, which has been widely exploited for signal transduction. Some proteins, such as troponin C (TnC) involved in muscle contraction, directly bind to and sense Ca2+. However, in other cases Ca2+ is sensed through intermediate calcium sensors such as calmodulin (CALM).
Class
Environmental Information Processing; Signal transduction
Pathway map
dre04020  Calcium signaling pathway
dre04020

Other DBs
GO: 0019722
Organism
Danio rerio (zebrafish) [GN:dre]
Gene
100000160  fgfr4; fibroblast growth factor receptor 4 precursor [KO:K05095] [EC:2.7.10.1]
100000544  ptger3; prostaglandin E2 receptor EP3 subtype isoform X2 [KO:K04260]
100000981  htr2cl1; 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled-like 1 [KO:K04157]
100001113  mcoln3b; mucolipin-3 isoform X1 [KO:K04994]
100001530  oxtra; oxytocin receptor [KO:K04229]
100001532  plcb3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
100001636  drd6b; D(5)-like dopamine receptor [KO:K05840]
100002038  tnnc2.1; troponin C, skeletal muscle [KO:K12042]
100002125  tacr2; substance-K receptor [KO:K04223]
100002285  drd7; dopamine receptor D7 [KO:K05840]
100002448  mst1ra; macrophage-stimulating protein receptor isoform X2 [KO:K05100] [EC:2.7.10.1]
100002627  ptafr; platelet-activating factor receptor [KO:K04279]
100003342  grin2ca; glutamate receptor, ionotropic, N-methyl D-aspartate 2Ca precursor [KO:K05211]
100003514  prkcg; protein kinase C alpha type [KO:K19663] [EC:2.7.11.13]
100003535  ptger1c; prostaglandin E receptor 1c (subtype EP1) [KO:K04258]
100003539  tacr1a; tachykinin receptor 1a [KO:K04222]
100003770  mylk5; myosin light chain kinase, smooth muscle isoform X2 [KO:K00907] [EC:2.7.11.18]
100004739  cysltr2a; cysteinyl leukotriene receptor 2 [KO:K04323]
100004938  si:dkey-63b1.1; B2 bradykinin receptor [KO:K03916]
100005049  fgf1b; fibroblast growth factor 1b [KO:K18496]
100005590  hrh2b; histamine receptor H2b [KO:K04150]
100005675  grin1b; glutamate receptor ionotropic, NMDA 1b precursor [KO:K05208]
100005700  stim1b; stromal interaction molecule 1b precursor [KO:K16059]
100005852  fgf22; fibroblast growth factor 22 precursor [KO:K04358]
100006675  prkcba; protein kinase C, beta a [KO:K19662] [EC:2.7.11.13]
100007677  erbb4a; receptor tyrosine-protein kinase erbB-4 precursor [KO:K05085] [EC:2.7.10.1]
100034402  tgfa; protransforming growth factor alpha precursor [KO:K08774]
100037315  adrb2b; adrenoceptor beta 2, surface b [KO:K04142]
100038774  si:dkey-251i10.1; uncharacterized protein LOC100038774 [KO:K05863]
100038775  htr5aa; 5-hydroxytryptamine (serotonin) receptor 5A, genome duplicate a [KO:K04161]
100038781  trdn; triadin isoform X12 [KO:K23449]
100124597  f2r2.1; coagulation factor II thrombin receptor 2.1 precursor [KO:K03914]
100126126  ryr2a; ryanodine receptor 2 [KO:K04962]
100134855  mst1rb; macrophage-stimulating protein receptor [KO:K05100] [EC:2.7.10.1]
100137117  cckbra; Cholecystokinin receptor-like [KO:K04194]
100144566  camk1da; calcium/calmodulin-dependent protein kinase type 1D [KO:K08794] [EC:2.7.11.17]
100148976  adcy8; adenylate cyclase type 8 [KO:K08048] [EC:4.6.1.1]
100149080  plcb1l; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 [KO:K05858] [EC:3.1.4.11]
100149100  adra1ba; alpha-1A adrenergic receptor [KO:K04136]
100149161  [KO:K03914]
100149388  itpr1b; inositol 1,4,5-trisphosphate-gated calcium channel ITPR1 isoform X1 [KO:K04958]
100149482  [KO:K05212]
100149598  chrm3b; muscarinic acetylcholine receptor M3 [KO:K04131]
100150090  sphk2; sphingosine kinase 2 [KO:K04718] [EC:2.7.1.91]
100150246  grm1b; metabotropic glutamate receptor 1b precursor [KO:K04603]
100150664  met; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
100321746  calml4b; calmodulin-like protein 4 [KO:K02183]
100330960  bdkrb2; B2 bradykinin receptor [KO:K03916]
100331465  cckbrb; cholecystokinin receptor [KO:K04194]
100331840  [KO:K04718] [EC:2.7.1.91]
100332130  sln; sarcolipin [KO:K22642]
100332381  si:ch73-60h1.1; calcium/calmodulin-dependent protein kinase type IV [KO:K05869] [EC:2.7.11.17]
100332913  grm5b; metabotropic glutamate receptor 5b precursor [KO:K04604]
100333101  grin3bb; glutamate receptor ionotropic, NMDA 3B isoform X1 [KO:K05214]
100333254  nfatc2a; nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332]
100333270  [KO:K04224]
100333455  agtr1b; type-1 angiotensin II receptor A [KO:K04166]
100333648  grin2cb; glutamate receptor ionotropic, NMDA 2C [KO:K05211]
100333702  adcy9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
100333967  prkcab; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
100334116  hgfb; hepatocyte growth factor [KO:K05460]
100334819  mcoln3a; mucolipin-3 isoform X2 [KO:K04994]
100334881  stim2a; stromal interaction molecule 2 isoform X1 [KO:K18196]
100334883  [KO:K05210]
100334891  [KO:K04856]
100334963  cysltr3; cysteinyl leukotriene receptor 2 [KO:K04322]
100535026  ltb4r2a; leukotriene B4 receptor 2a [KO:K04297]
100535718  pdgfd; platelet-derived growth factor D [KO:K05450]
100536080  htr7; 5-hydroxytryptamine receptor 7 [KO:K04163]
100536162  pde1cb; dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform X4 [KO:K13755] [EC:3.1.4.17]
100536970  drd5a; D(1B) dopamine receptor [KO:K05840]
100537296  ltb4r2b; leukotriene B4 receptor 2b [KO:K04297]
100537531  chrna8; CHRNA7-FAM7A fusion protein isoform X2 [KO:K04809]
100537538  plcb4a; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 [KO:K05858] [EC:3.1.4.11]
101882451  [KO:K04809]
101882850  htr4; 5-hydroxytryptamine receptor 4 isoform X1 [KO:K04160]
101883614  fgf9; fibroblast growth factor 4B [KO:K04358]
101883748  [KO:K04282]
101883995  pde1ca; dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A [KO:K13755] [EC:3.1.4.17]
101884360  [KO:K08049] [EC:4.6.1.1]
101885082  gdnfb; glial cell line-derived neurotrophic factor [KO:K05452]
101885162  si:ch73-383l1.1; receptor tyrosine-protein kinase erbB-4 isoform X1 [KO:K05085] [EC:2.7.10.1]
101886891  [KO:K01242] [EC:3.2.2.6 2.4.99.20]
102216340  tbxa2r; thromboxane A2 receptor [KO:K04264]
110438919  grin2ba; glutamate receptor ionotropic, NMDA 2B isoform X1 [KO:K05210]
114410  casq2; calsequestrin-2 precursor [KO:K23445]
114447  cxcr4b; C-X-C chemokine receptor type 4b [KO:K04189]
114550  ednraa; endothelin receptor type Aa precursor [KO:K04197]
137487188  [KO:K04359]
140747  cxcr4a; C-X-C chemokine receptor type 4a [KO:K04189]
170581  cacna1c; voltage-dependent L-type calcium channel subunit alpha-1C [KO:K04850]
192321  slc25a5; ADP/ATP translocase 2 [KO:K05863]
192322  calm2b; calmodulin 2b, (phosphorylase kinase, delta) [KO:K02183]
245950  ptk2bb; protein tyrosine kinase 2 beta, b [KO:K05871] [EC:2.7.10.2]
259258  p2rx4a; P2X purinoceptor 4a [KO:K05218]
259260  mst1; hepatocyte growth factor-like protein precursor [KO:K23441]
260440  atp2a1; sarcoplasmic/endoplasmic reticulum calcium ATPase 1 [KO:K05853] [EC:7.2.2.10]
30121  flt4; vascular endothelial growth factor receptor 3 precursor [KO:K05097] [EC:2.7.10.1]
30270  ngfa; neurotrophin-7 precursor [KO:K02582]
30442  ednrba; endothelin receptor Ba precursor [KO:K04198]
30512  ret; proto-oncogene tyrosine-protein kinase receptor Ret precursor [KO:K05126] [EC:2.7.10.1]
30538  fgf8a; fibroblast growth factor 8 precursor [KO:K04358]
30546  ntrk1; high affinity nerve growth factor receptor precursor [KO:K03176] [EC:2.7.10.1]
30549  fgf3; fibroblast growth factor 3 precursor [KO:K04358]
30560  fgf6a; fibroblast growth factor 6a [KO:K04358]
30682  vegfaa; vascular endothelial growth factor A-A isoform 1 precursor [KO:K05448]
30705  fgfr1a; fibroblast growth factor receptor 1-A isoform 1 precursor [KO:K04362] [EC:2.7.10.1]
321808  calm3b; calmodulin 3b (phosphorylase kinase, delta) [KO:K02183]
322126  vdac2; voltage-dependent anion-selective channel protein 2 [KO:K15040]
322720  itpkcb; inositol-trisphosphate 3-kinase Cb [KO:K00911] [EC:2.7.1.127]
327067  slc25a4; ADP/ATP translocase 1 [KO:K05863]
327379  calm3a; calmodulin 3a (phosphorylase kinase, delta) [KO:K02183]
334582  vdac1; non-selective voltage-gated ion channel VDAC1 [KO:K05862]
335654  camk1ga; calcium/calmodulin-dependent protein kinase IGa [KO:K08794] [EC:2.7.11.17]
336121  calm2a; calmodulin 2a (phosphorylase kinase, delta) [KO:K02183]
337489  plcd1b; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1b [KO:K05857] [EC:3.1.4.11]
352938  chrm2a; muscarinic acetylcholine receptor M2a [KO:K04130]
352940  fgfr2; fibroblast growth factor receptor 2 isoform 1 precursor [KO:K05093] [EC:2.7.10.1]
353247  tnnc1a; troponin C type 1a (slow) [KO:K05865]
359829  fgf18a; fibroblast growth factor 18a precursor [KO:K04358]
359830  fgf10a; fibroblast growth factor 10a precursor [KO:K04358]
359831  fgf24; fibroblast growth factor 24 precursor [KO:K04358]
368199  bdkrb1; B1 bradykinin receptor [KO:K03916]
368217  calm1b; calmodulin-1b [KO:K02183]
368245  fgf19; fibroblast growth factor 19 isoform 1 [KO:K22603]
368475  htr5ab; 5-hydroxytryptamine (serotonin) receptor 5A, genome duplicate b [KO:K04161]
368717  itpka; inositol-trisphosphate 3-kinase A [KO:K00911] [EC:2.7.1.127]
373867  plcg1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 [KO:K01116] [EC:3.1.4.11]
373879  p2rx5; P2X purinoceptor 5 [KO:K05219]
378478  egfra; epidermal growth factor receptor precursor [KO:K04361] [EC:2.7.10.1]
378480  pdgfaa; platelet-derived growth factor alpha polypeptide a precursor [KO:K04359]
378746  atp2b1a; plasma membrane calcium-transporting ATPase 1 [KO:K05850] [EC:7.2.2.10]
386635  erbb3a; receptor tyrosine-protein kinase erbB-3a precursor [KO:K05084] [EC:2.7.10.1]
386856  pdgfra; platelet-derived growth factor receptor alpha precursor [KO:K04363] [EC:2.7.10.1]
386966  erbb2; receptor tyrosine-protein kinase erbB-2 precursor [KO:K05083] [EC:2.7.10.1]
387296  p2rx1; P2X purinoceptor 1 [KO:K05215]
387297  p2rx2; P2X purinoceptor 2 [KO:K05216]
387298  p2rx7; P2X purinoceptor 7 [KO:K05220]
387299  p2rx8; purinergic receptor P2X, ligand-gated ion channel, 8 [KO:K05219]
387300  p2rx3b; P2X purinoceptor 3b [KO:K05217]
387301  p2rx4b; P2X purinoceptor 4b [KO:K05218]
393186  zgc:56235; Voltage-dependent anion-selective channel protein 2-like [KO:K15041]
393733  fgf1a; putative fibroblast growth factor 1 [KO:K18496]
393802  camk1gb; calcium/calmodulin-dependent protein kinase IGb [KO:K08794] [EC:2.7.11.17]
393937  phkg2; phosphorylase b kinase gamma catalytic chain, liver/testis isoform [KO:K00871] [EC:2.7.11.19]
393940  atp2a2a; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 [KO:K05853] [EC:7.2.2.10]
393953  prkcbb; protein kinase C beta type [KO:K19662] [EC:2.7.11.13]
393998  prkacba; protein kinase, cAMP-dependent, catalytic, beta a [KO:K04345] [EC:2.7.11.11]
394123  mcoln2; mucolipin-2 [KO:K04993]
394199  chrna7a; neuronal acetylcholine receptor subunit alpha-7a [KO:K04809]
402892  orai1b; calcium release-activated calcium channel protein 1 [KO:K16056]
402920  lhcgr; lutropin-choriogonadotropic hormone receptor precursor [KO:K04248]
403045  egf; pro-epidermal growth factor isoform 1 precursor [KO:K04357]
403049  vegfc; vascular endothelial growth factor C precursor [KO:K05449]
403310  cacna1da; calcium channel, voltage-dependent, L type, alpha 1D subunit, a [KO:K04851]
403311  cacna1db; voltage-dependent L-type calcium channel subunit alpha-1D [KO:K04851]
404036  nos2a; nitric oxide synthase 2a, inducible [KO:K13241] [EC:1.14.13.39]
404231  fgf2; fibroblast growth factor 2 [KO:K18497]
405791  cacna1sb; calcium channel, voltage-dependent, L type, alpha 1S subunit, b [KO:K04857]
405866  ednrab; endothelin receptor type Ab precursor [KO:K04197]
406529  vdac3; voltage-dependent anion-selective channel protein 3 [KO:K15041]
406660  calm1a; calmodulin-1a [KO:K02183]
406689  mcoln1a; mucolipin-1a [KO:K04992]
407700  plcb4b; LOW QUALITY PROTEIN: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 [KO:K05858] [EC:3.1.4.11]
407724  gnal2; guanine nucleotide binding protein (G protein), alpha activating activity polypeptide, olfactory type 2 [KO:K04633]
407737  fgf17; fibroblast growth factor 17 precursor [KO:K04358]
415175  tnnc1b; troponin C type 1b (slow) [KO:K05865]
436745  atp2b3a; plasma membrane calcium-transporting ATPase 3a isoform 2 [KO:K05850] [EC:7.2.2.10]
436815  camk2d2; calcium/calmodulin-dependent protein kinase type II delta 2 chain [KO:K04515] [EC:2.7.11.17]
445076  prkacab; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
445208  camk2d1; calcium/calmodulin-dependent protein kinase type II delta 1 chain isoform 1 [KO:K04515] [EC:2.7.11.17]
445226  casq1a; calsequestrin-1a precursor [KO:K23468]
445232  gna15.1; guanine nucleotide-binding protein subunit alpha-15.1 [KO:K04637]
445297  gna14; guanine nucleotide-binding protein subunit alpha-14 [KO:K04636]
447814  ppp3r1b; calcineurin subunit B type 1b [KO:K06268]
447887  ppifa; peptidylprolyl isomerase Fa [KO:K09565] [EC:5.2.1.8]
449707  mylk4b; myosin light chain kinase family member 4 isoform X4 [KO:K00907] [EC:2.7.11.18]
449864  grin2da; glutamate receptor ionotropic, NMDA 2D [KO:K05212]
492467  gnal; guanine nucleotide-binding protein G(olf) subunit alpha [KO:K04633]
492486  adra1bb; adrenoceptor alpha 1Bb [KO:K04136]
492576  mylkb; myosin light chain kinase, smooth muscle [KO:K00907] [EC:2.7.11.18]
493181  fgf7; fibroblast growth factor 7 precursor [KO:K04358]
493613  gna11b; guanine nucleotide-binding protein subunit alpha-11b [KO:K04635]
493781  hgfa; hepatocyte growth factor a precursor [KO:K05460]
494454  fgf5; fibroblast growth factor 5 precursor [KO:K04358]
494455  fgf6b; fibroblast growth factor 6b [KO:K04358]
494456  fgf23; fibroblast growth factor 23 precursor [KO:K22428]
494489  atp2a1l; ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1, like [KO:K05853] [EC:7.2.2.10]
497384  prkcaa; protein kinase C, alpha, a [KO:K02677] [EC:2.7.11.13]
497639  fgf18b; fibroblast growth factor 18b precursor [KO:K04358]
544664  erbb3b; receptor tyrosine-protein kinase erbB-3b precursor [KO:K05084] [EC:2.7.10.1]
544667  flt1; vascular endothelial growth factor receptor 1 isoform 1 precursor [KO:K05096] [EC:2.7.10.1]
550270  camk4; calcium/calmodulin-dependent protein kinase type IV [KO:K05869] [EC:2.7.11.17]
550436  camk2a; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform 2 [KO:K04515] [EC:2.7.11.17]
550554  ppp3cb; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform [KO:K04348] [EC:3.1.3.16]
553296  [KO:K23450]
553489  slc8a1a; sodium/calcium exchanger 1a precursor [KO:K05849]
553675  cysltr1; cysteinyl leukotriene receptor 1 [KO:K04322]
553978  chrm5a; muscarinic acetylcholine receptor M5a [KO:K04133]
554046  phkg1b; phosphorylase kinase, gamma 1b (muscle) [KO:K00871] [EC:2.7.11.19]
554230  kdr; vascular endothelial growth factor receptor 2 precursor [KO:K05098] [EC:2.7.10.1]
555443  plcd1a; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1a [KO:K05857] [EC:3.1.4.11]
555482  tacr3a; tachykinin receptor 3a [KO:K04224]
555516  chrm2b; muscarinic acetylcholine receptor M2 [KO:K04130]
555548  pln1; cardiac phospholamban [KO:K05852]
555576  grm1a; metabotropic glutamate receptor 1 isoform X1 [KO:K04603]
555612  orai2; protein orai-2 [KO:K16057]
555939  avpr1ab; arginine vasopressin receptor 1Ab [KO:K04226]
555941  cacna1ba; calcium channel, voltage-dependent, N type, alpha 1B subunit, a [KO:K04849]
555945  camk1a; calcium/calmodulin-dependent protein kinase type 1 isoform X2 [KO:K08794] [EC:2.7.11.17]
556160  gna14a; guanine nucleotide-binding protein subunit alpha-14 [KO:K04636]
556199  phka2; phosphorylase b kinase regulatory subunit alpha, liver isoform isoform X2 [KO:K07190]
556360  stim1a; stromal interaction molecule 1a precursor [KO:K16059]
556431  trhr2; thyrotropin releasing hormone receptor 2 [KO:K04282]
557026  adcy1a; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
557194  adrb1; beta-1 adrenergic receptor [KO:K04141]
557258  ptk2ba; protein-tyrosine kinase 2-beta isoform X1 [KO:K05871] [EC:2.7.10.2]
557259  adra1ab; alpha-1A adrenergic receptor [KO:K04135]
557353  gnas; guanine nucleotide-binding protein G(s) subunit alpha isoform X1 [KO:K04632]
557430  atp2b2; plasma membrane calcium-transporting ATPase 2 [KO:K05850] [EC:7.2.2.10]
557499  slc8a4b; solute carrier family 8 member 4b precursor [KO:K05849]
557902  adcy2b; adenylate cyclase type 2b [KO:K08042] [EC:4.6.1.1]
557926  ppp3cca; protein phosphatase 3, catalytic subunit, gamma isozyme, a [KO:K04348] [EC:3.1.3.16]
558154  vegfab; vascular endothelial growth factor Ab isoform 1 precursor [KO:K05448]
558248  adrb3a; adrenoceptor beta 3a [KO:K04143]
558477  f2r; proteinase-activated receptor 1 precursor [KO:K03914]
558525  atp2b3b; plasma membrane calcium-transporting ATPase 3b [KO:K05850] [EC:7.2.2.10]
558685  mylk2; myosin light chain kinase 2, skeletal/cardiac muscle [KO:K00907] [EC:2.7.11.18]
558878  trhra; thyrotropin-releasing hormone receptor [KO:K04282]
559089  si:dkey-247m21.3; 5-hydroxytryptamine receptor 4 isoform X1 [KO:K04160]
559201  tacr3l; tachykinin receptor 3-like [KO:K04224]
559236  unm_hu7910; calponin homology domain-containing protein DDB_G0272472 isoform X2 [KO:K00476] [EC:1.14.11.16]
559315  ptger1a; prostaglandin E receptor 1a (subtype EP1) [KO:K04258]
559529  pdgfrb; platelet-derived growth factor receptor beta precursor [KO:K05089] [EC:2.7.10.1]
559630  fgf20a; fibroblast growth factor 20a [KO:K04358]
559806  htr2ab; 5-hydroxytryptamine receptor 2A [KO:K04157]
559964  cacna1fb; calcium channel, voltage-dependent, L type, alpha 1F subunit [KO:K04853]
559976  grin2bb; glutamate receptor, ionotropic, N-methyl D-aspartate 2B, genome duplicate b [KO:K05210]
560081  ednrbb; endothelin receptor type B [KO:K04198]
560100  adora2b; adenosine receptor A2b [KO:K04267]
560151  calml4a; calmodulin-like protein 4a [KO:K02183]
560410  si:ch211-132f19.7; adenylate cyclase type 8 [KO:K08048] [EC:4.6.1.1]
560561  slc8a3; sodium/calcium exchanger 3 precursor [KO:K05849]
560564  pdgfc; platelet-derived growth factor C isoform X3 [KO:K05450]
560719  si:dkey-206f10.1; adenylate cyclase type 8 [KO:K08048] [EC:4.6.1.1]
560808  htr2aa; 5-hydroxytryptamine receptor 2A isoform X2 [KO:K04157]
560875  cacna1ha; voltage-dependent T-type calcium channel subunit alpha-1H [KO:K04855]
561190  atp2b1b; plasma membrane calcium-transporting ATPase 4 [KO:K05850] [EC:7.2.2.10]
561350  ryr3; ryanodine receptor 3 isoform X1 [KO:K04963]
561475  plcd4b; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 [KO:K05857] [EC:3.1.4.11]
561491  chrm5b; muscarinic acetylcholine receptor M5b [KO:K04133]
561635  mylk3; myosin light chain kinase 3 [KO:K00907] [EC:2.7.11.18]
561682  nfatc4; nuclear factor of activated T-cells, cytoplasmic 4 [KO:K17334]
561701  adora2aa; adenosine A2a receptor a [KO:K04266]
561747  plcg2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
561772  nfatc3a; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
562059  cacna1aa; voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform X17 [KO:K04344]
562064  camk2b1; calcium/calmodulin-dependent protein kinase (CaM kinase) II beta 1 [KO:K04515] [EC:2.7.11.17]
562111  htr7a; 5-hydroxytryptamine receptor 7 [KO:K04163]
562289  tfeb; transcription factor EB [KO:K15590]
562569  plcd3b; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3-A-like [KO:K05857] [EC:3.1.4.11]
562585  itpr2; inositol 1,4,5-trisphosphate-gated calcium channel ITPR2 [KO:K04959]
562625  gna15.4; guanine nucleotide binding protein (G protein), alpha 15 (Gq class), tandem duplicate 4 [KO:K04637]
562640  si:dkey-28b4.8; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 [KO:K05853] [EC:7.2.2.10]
562796  cacna1bb; voltage-dependent N-type calcium channel subunit alpha-1B isoform X1 [KO:K04849]
562919  itpkca; inositol-trisphosphate 3-kinase C [KO:K00911] [EC:2.7.1.127]
563019  itpkb; inositol-trisphosphate 3-kinase A [KO:K00911] [EC:2.7.1.127]
563111  cysltr2b; cysteinyl leukotriene receptor 2 [KO:K04323]
563147  prkacbb; protein kinase, cAMP-dependent, catalytic, beta b [KO:K04345] [EC:2.7.11.11]
563297  grin2aa; glutamate receptor ionotropic, NMDA 2A [KO:K05209]
563567  [KO:K05840]
563654  nos2b; nitric oxide synthase 2b, inducible [KO:K13241] [EC:1.14.13.39]
563724  adcy2a; adenylate cyclase type 2 isoform X2 [KO:K08042] [EC:4.6.1.1]
563901  stim2b; stromal interaction molecule 2 [KO:K18196]
563904  cacna1g; voltage-dependent T-type calcium channel subunit alpha-1G [KO:K04854]
563953  gna11a; guanine nucleotide-binding protein subunit alpha-11a [KO:K04634]
564017  tacr1b; tachykinin receptor 1b [KO:K04222]
564064  prkacaa; protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate a [KO:K04345] [EC:2.7.11.11]
564274  cacna1e; voltage-dependent R-type calcium channel subunit alpha-1E isoform X1 [KO:K04852]
564337  ppp3r1a; calcineurin subunit B type 1 [KO:K06268]
564465  pde1a; dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform X1 [KO:K13755] [EC:3.1.4.17]
564719  adcy3b; adenylate cyclase type 3 [KO:K08043] [EC:4.6.1.1]
564770  fgf20b; fibroblast growth factor 20b [KO:K04358]
564832  grin3a; LOW QUALITY PROTEIN: glutamate receptor ionotropic, NMDA 3A [KO:K05213]
564945  ptger1b; prostaglandin E receptor 1b (subtype EP1) [KO:K04258]
565241  ppp3ccb; protein phosphatase 3, catalytic subunit, gamma isozyme, b [KO:K04348] [EC:3.1.3.16]
565304  htr7b; 5-hydroxytryptamine receptor 7-like isoform X1 [KO:K04163]
565379  phkg1a; phosphorylase kinase, gamma 1a (muscle) [KO:K00871] [EC:2.7.11.19]
565669  plcd4a; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 [KO:K05857] [EC:3.1.4.11]
565838  adrb2a; adrenoceptor beta 2, surface a [KO:K04142]
566118  adora2ab; adenosine A2a receptor b [KO:K04266]
566141  chrna11; cholinergic receptor, nicotinic, alpha 11 precursor [KO:K04809]
566351  cacna1ia; voltage-dependent T-type calcium channel subunit alpha-1I [KO:K04856]
566370  slc25a6; ADP/ATP translocase 3 [KO:K05863]
566411  grin3ba; glutamate receptor ionotropic, NMDA 3B [KO:K05214]
566671  orai1a; calcium release-activated calcium channel protein 1 [KO:K16056]
566845  mylk4a; myosin light chain kinase 2, skeletal/cardiac muscle isoform X2 [KO:K00907] [EC:2.7.11.18]
566869  nfatc3b; nuclear factor of activated T-cells, cytoplasmic 3 isoform X2 [KO:K17333]
567212  slc8a2b; sodium/calcium exchanger 2b precursor [KO:K05849]
567289  grpr; gastrin-releasing peptide receptor [KO:K04169]
567498  [KO:K05840]
567534  tpcn1; two pore channel protein 1 isoform X2 [KO:K16896]
567611  itpr1a; inositol 1,4,5-trisphosphate-gated calcium channel ITPR1 isoform X1 [KO:K04958]
567702  cacna1eb; voltage-dependent R-type calcium channel subunit alpha-1E [KO:K04852]
567905  fgfr1b; fibroblast growth factor receptor 1b precursor [KO:K04362] [EC:2.7.10.1]
568126  drd1b; dopamine receptor D1b [KO:K04144]
568265  atp2a2b; sarcoplasmic/endoplasmic reticulum calcium ATPase 2b [KO:K05853] [EC:7.2.2.10]
568269  htr6; 5-hydroxytryptamine receptor 6 [KO:K04162]
568288  plce1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 [KO:K05860] [EC:3.1.4.11]
568315  nfatc1; nuclear factor of activated T-cells, cytoplasmic 1 [KO:K04446]
568406  grm5a; glutamate receptor, metabotropic 5a [KO:K04604]
568463  ryr2b; ryanodine receptor 2 isoform X3 [KO:K04962]
568512  slc8a4a; solute carrier family 8 member 4a precursor [KO:K05849]
568614  adra1d; alpha-1D adrenergic receptor [KO:K04137]
568668  ntrk3a; NT-3 growth factor receptor precursor [KO:K05101] [EC:2.7.10.1]
568671  atp2a3; sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform X2 [KO:K05853] [EC:7.2.2.10]
568726  adcy7; adenylate cyclase type 7 [KO:K08047] [EC:4.6.1.1]
569038  cckar; cholecystokinin receptor type A [KO:K04194]
569040  plcd3a; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3-A [KO:K05857] [EC:3.1.4.11]
569344  ntsr1; neurotensin receptor type 1 isoform X1 [KO:K04211]
569376  plcb2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11]
569382  trhrb; thyrotropin-releasing hormone receptor b [KO:K04282]
569480  slc8a2a; sodium/calcium exchanger 2a precursor [KO:K05849]
569499  adcy1b; adenylate cyclase type 1b [KO:K08041] [EC:4.6.1.1]
569510  mylka; myosin light chain kinase, smooth muscle isoform X1 [KO:K00907] [EC:2.7.11.18]
569528  cacna1ab; calcium channel, voltage-dependent, P/Q type, alpha 1A subunit, b [KO:K04344]
569566  fgfr1bl; fibroblast growth factor receptor 1 [KO:K04362] [EC:2.7.10.1]
569706  phkb; phosphorylase b kinase regulatory subunit beta isoform X1 [KO:K07190]
569836  erbb4b; receptor tyrosine-protein kinase erbB-4 isoform X2 [KO:K05085] [EC:2.7.10.1]
570108  gnaq; guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
570240  ntrk2b; neurotrophic tyrosine kinase, receptor, type 2b precursor [KO:K04360] [EC:2.7.10.1]
570245  ryr1b; ryanodine receptor 1b [KO:K04961]
570435  fgf4; fibroblast growth factor 4 precursor [KO:K04358]
570493  grin2ab; glutamate receptor ionotropic, NMDA 2A isoform X1 [KO:K05209]
570683  cacna1sa; calcium channel, voltage-dependent, L type, alpha 1S subunit, a [KO:K04857]
571431  [KO:K04361] [EC:2.7.10.1]
571591  avpr1aa; arginine vasopressin receptor 1Aa [KO:K04226]
571679  chrm3a; muscarinic acetylcholine receptor M3 [KO:K04131]
571808  ptgfr; prostaglandin F2-alpha receptor [KO:K04262]
571825  adcy3a; adenylate cyclase type 3 [KO:K08043] [EC:4.6.1.1]
571865  [KO:K17332]
572143  htr7c; 5-hydroxytryptamine receptor 7 [KO:K04163]
572183  phka1a; phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform isoform X1 [KO:K07190]
58082  tnnc2.2; troponin C, skeletal muscle [KO:K12042]
58129  fgfr3; fibroblast growth factor receptor 3 precursor [KO:K05094] [EC:2.7.10.1]
58133  ngfb; nerve growth factor isoform 2 [KO:K02582]
58147  p2rx3a; P2X purinoceptor 3a [KO:K05217]
60658  nos1; nitric oxide synthase 1 [KO:K13240] [EC:1.14.13.39]
641328  ppifb; peptidyl-prolyl cis-trans isomerase F, mitochondrial [KO:K09565] [EC:5.2.1.8]
65089  fgf8b; fibroblast growth factor 8b precursor [KO:K04358]
65090  ntrk2a; BDNF/NT-3 growth factors receptor precursor [KO:K04360] [EC:2.7.10.1]
678512  vegfd; vascular endothelial growth factor D precursor [KO:K05449]
692065  fgf16; fibroblast growth factor 16 [KO:K04358]
724048  fgf21; fibroblast growth factor 21 [KO:K22429]
735302  hrh1; histamine H1 receptor [KO:K04149]
735303  hrh2a; histamine receptor H2a [KO:K04150]
751784  htr2b; 5-hydroxytryptamine receptor 2B [KO:K04157]
751792  fgf10b; fibroblast growth factor 10b [KO:K04358]
767745  grin1a; glutamate receptor ionotropic, NMDA 1a precursor [KO:K05208]
767757  casq1b; calsequestrin-1b precursor [KO:K23468]
767790  pdgfab; platelet-derived growth factor alpha polypeptide b precursor [KO:K04359]
768182  mcu; calcium uniporter protein, mitochondrial [KO:K20858]
777614  tpcn2; two pore channel protein 2 [KO:K14077]
791176  camk1db; calcium/calmodulin-dependent protein kinase 1Db isoform long [KO:K08794] [EC:2.7.11.17]
791855  camk2g1; calcium/calmodulin-dependent protein kinase (CaM kinase) II gamma 1 [KO:K04515] [EC:2.7.11.17]
792519  adrb3b; adrenoceptor beta 3b [KO:K04143]
792634  drd1a; D(1) dopamine receptor [KO:K04144]
792708  chrm1a; muscarinic acetylcholine receptor M1 isoform X1 [KO:K04129]
793359  camk2g2; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X25 [KO:K04515] [EC:2.7.11.17]
793708  cacna1fa; voltage-dependent L-type calcium channel subunit alpha-1D [KO:K04853]
79379  gdnfa; glial cell line-derived neurotrophic factor precursor [KO:K05452]
794026  camk1b; calcium/calmodulin-dependent protein kinase type 1 isoform X2 [KO:K08794] [EC:2.7.11.17]
794215  [KO:K03914]
794278  si:dkey-163m14.6; proteinase-activated receptor 1-like [KO:K03914]
794365  f2r2.2; proteinase-activated receptor 1-like [KO:K03914]
794574  ppp3ca; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform [KO:K04348] [EC:3.1.3.16]
794575  agtr1a; type-1 angiotensin II receptor [KO:K04166]
794658  chrm1b; muscarinic acetylcholine receptor M1 [KO:K04129]
794666  itpr3; inositol 1,4,5-trisphosphate-gated calcium channel ITPR3 [KO:K04960]
795916  mcoln1b; mucolipin-1b [KO:K04992]
796298  oxtrb; oxytocin receptor b [KO:K04229]
796490  pdgfbb; uncharacterized protein pdgfbb isoform X2 [KO:K04359]
796537  kdrl; vascular endothelial growth factor receptor kdr-like precursor [KO:K05096] [EC:2.7.10.1]
797199  slc8a1b; sodium/calcium exchanger 1b precursor [KO:K05849]
797212  [KO:K04160]
798222  [KO:K04515] [EC:2.7.11.17]
798498  adra1aa; adrenoceptor alpha 1Aa [KO:K04135]
798565  ryr1a; ryanodine receptor 1 isoform X2 [KO:K04961]
798577  ntrk3b; NT-3 growth factor receptor isoform X1 [KO:K05101] [EC:2.7.10.1]
798657  pdgfba; platelet-derived growth factor beta polypeptide a precursor [KO:K17386]
799067  [KO:K05852]
799082  si:dkey-163m14.2; proteinase-activated receptor 1 [KO:K03914]
799156  [KO:K03914]
799227  [KO:K03914]
Compound
C00002  ATP
C00004  NADH
C00076  Calcium cation
C00165  Diacylglycerol
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01330  Sodium cation
C06124  Sphingosine 1-phosphate
C11556  1-Phosphatidyl-1D-myo-inositol 3,5-bisphosphate
C13050  Cyclic ADP-ribose
C13051  Nicotinic acid adenine dinucleotide phosphate
Reference
PMID:12838335
  Authors
Berridge MJ, Bootman MD, Roderick HL.
  Title
Calcium signalling: dynamics, homeostasis and remodelling.
  Journal
Nat Rev Mol Cell Biol 4:517-29 (2003)
DOI:10.1038/nrm1155
Reference
PMID:11413485
  Authors
Berridge MJ, Lipp P, Bootman MD.
  Title
The versatility and universality of calcium signalling.
  Journal
Nat Rev Mol Cell Biol 1:11-21 (2000)
DOI:10.1038/35036035
Reference
PMID:15111104
  Authors
Wang MC, Dolphin A, Kitmitto A.
  Title
L-type voltage-gated calcium channels: understanding function through structure.
  Journal
FEBS Lett 564:245-50 (2004)
DOI:10.1016/S0014-5793(04)00253-4
Reference
PMID:11299192
  Authors
Ferrier GR, Howlett SE.
  Title
Cardiac excitation-contraction coupling: role of membrane potential in regulation of contraction.
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Am J Physiol Heart Circ Physiol 280:H1928-44 (2001)
DOI:10.1152/ajpheart.2001.280.5.H1928
Reference
PMID:11698232
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Keef KD, Hume JR, Zhong J.
  Title
Regulation of cardiac and smooth muscle Ca(2+) channels (Ca(V)1.2a,b) by protein kinases.
  Journal
Am J Physiol Cell Physiol 281:C1743-56 (2001)
DOI:10.1152/ajpcell.2001.281.6.C1743
Reference
PMID:8125957
  Authors
Hell JW, Appleyard SM, Yokoyama CT, Warner C, Catterall WA.
  Title
Differential phosphorylation of two size forms of the N-type calcium channel alpha 1 subunit which have different COOH termini.
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J Biol Chem 269:7390-6 (1994)
Reference
PMID:15000521
  Authors
Yunker AM.
  Title
Modulation and pharmacology of low voltage-activated ("T-Type") calcium channels.
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J Bioenerg Biomembr 35:577-98 (2003)
DOI:10.1023/B:JOBB.0000008025.65675.37
Reference
PMID:9149541
  Authors
Yakel JL.
  Title
Calcineurin regulation of synaptic function: from ion channels to transmitter release and gene transcription.
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Trends Pharmacol Sci 18:124-34 (1997)
DOI:10.1016/S0165-6147(97)01046-8
Reference
PMID:10997573
  Authors
Fukunaga K, Miyamoto E.
  Title
A working model of CaM kinase II activity in hippocampal long-term potentiation and memory.
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Neurosci Res 38:3-17 (2000)
DOI:10.1016/S0168-0102(00)00139-5
Reference
PMID:9235901
  Authors
Della Rocca GJ, van Biesen T, Daaka Y, Luttrell DK, Luttrell LM, Lefkowitz RJ.
  Title
Ras-dependent mitogen-activated protein kinase activation by G protein-coupled receptors. Convergence of Gi- and Gq-mediated pathways on calcium/calmodulin, Pyk2, and Src kinase.
  Journal
J Biol Chem 272:19125-32 (1997)
DOI:10.1074/jbc.272.31.19125
Reference
PMID:7861177
  Authors
Furuichi T, Mikoshiba K.
  Title
Inositol 1, 4, 5-trisphosphate receptor-mediated Ca2+ signaling in the brain.
  Journal
J Neurochem 64:953-60 (1995)
DOI:10.1046/j.1471-4159.1995.64030953.x
Reference
PMID:14572802
  Authors
Bruce JI, Straub SV, Yule DI.
  Title
Crosstalk between cAMP and Ca2+ signaling in non-excitable cells.
  Journal
Cell Calcium 34:431-44 (2003)
DOI:10.1016/S0143-4160(03)00150-7
Reference
PMID:10331643
  Authors
Lee HC, Munshi C, Graeff R.
  Title
Structures and activities of cyclic ADP-ribose, NAADP and their metabolic enzymes.
  Journal
Mol Cell Biochem 193:89-98 (1999)
DOI:10.1007/978-1-4419-8740-2_13
Reference
PMID:11080247
  Authors
Crompton M.
  Title
Mitochondrial intermembrane junctional complexes and their role in cell death.
  Journal
J Physiol 529 Pt 1:11-21 (2000)
DOI:10.1111/j.1469-7793.2000.00011.x
Reference
PMID:10508738
  Authors
Grewal SS, York RD, Stork PJ.
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Extracellular-signal-regulated kinase signalling in neurons.
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Curr Opin Neurobiol 9:544-53 (1999)
DOI:10.1016/S0959-4388(99)00010-0
Reference
PMID:12972622
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Trushin SA, Pennington KN, Carmona EM, Asin S, Savoy DN, Billadeau DD, Paya CV.
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Protein kinase Calpha (PKCalpha) acts upstream of PKCtheta to activate IkappaB kinase and NF-kappaB in T lymphocytes.
  Journal
Mol Cell Biol 23:7068-81 (2003)
DOI:10.1128/MCB.23.19.7068-7081.2003
Reference
PMID:14517314
  Authors
Hutchins JR, Dikovskaya D, Clarke PR.
  Title
Regulation of Cdc2/cyclin B activation in Xenopus egg extracts via inhibitory phosphorylation of Cdc25C phosphatase by Ca(2+)/calmodulin-dependent protein [corrected] kinase II.
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Mol Biol Cell 14:4003-14 (2003)
DOI:10.1091/mbc.E03-02-0061
Reference
PMID:21338471
  Authors
Tornquist K
  Title
Sphingosine 1-phosphate, sphingosine kinase and autocrine calcium signalling in thyroid cells.
  Journal
Acta Physiol (Oxf) 204:151-7 (2012)
DOI:10.1111/j.1748-1716.2011.02265.x
Reference
PMID:22129055
  Authors
Feske S
  Title
Immunodeficiency due to defects in store-operated calcium entry.
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Ann N Y Acad Sci 1238:74-90 (2011)
DOI:10.1111/j.1749-6632.2011.06240.x
Reference
PMID:22002090
  Authors
Giachini FR, Lima VV, Hannan JL, Carneiro FS, Webb RC, Tostes RC
  Title
STIM1/Orai1-mediated store-operated Ca2+ entry: the tip of the iceberg.
  Journal
Braz J Med Biol Res 44:1080-7 (2011)
DOI:10.1590/S0100-879X2011007500133
Reference
PMID:19172794
  Authors
Baba Y, Kurosaki T
  Title
[Regulation of store-operated calcium entry by STIM1].
  Journal
Seikagaku 80:1123-8 (2008)
Reference
PMID:19475418
  Authors
Galione A, Evans AM, Ma J, Parrington J, Arredouani A, Cheng X, Zhu MX
  Title
The acid test: the discovery of two-pore channels (TPCs) as NAADP-gated endolysosomal Ca(2+) release channels.
  Journal
Pflugers Arch 458:869-76 (2009)
DOI:10.1007/s00424-009-0682-y
Reference
PMID:19434403
  Authors
Beard NA, Wei L, Dulhunty AF
  Title
Ca(2+) signaling in striated muscle: the elusive roles of triadin, junctin, and calsequestrin.
  Journal
Eur Biophys J 39:27-36 (2009)
DOI:10.1007/s00249-009-0449-6
Reference
PMID:26228554
  Authors
Marty I
  Title
Triadin regulation of the ryanodine receptor complex.
  Journal
J Physiol 593:3261-6 (2015)
DOI:10.1113/jphysiol.2014.281147
Reference
PMID:20807542
  Authors
Arvanitis DA, Vafiadaki E, Sanoudou D, Kranias EG
  Title
Histidine-rich calcium binding protein: the new regulator of sarcoplasmic reticulum calcium cycling.
  Journal
J Mol Cell Cardiol 50:43-9 (2011)
DOI:10.1016/j.yjmcc.2010.08.021
Related
pathway
dre04010  MAPK signaling pathway
dre04070  Phosphatidylinositol signaling system
dre04210  Apoptosis
KO pathway
ko04020   

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