KEGG   PATHWAY: elk05169
Entry
elk05169                    Pathway                                
Name
Epstein-Barr virus infection - Enhydra lutris kenyoni (northern sea otter)
Description
Epstein-Barr virus (EBV) is a gamma-herpes virus that widely infects human populations predominantly at an early age but remains mostly asymptomatic. EBV has been linked to a wide spectrum of human malignancies, including nasopharyngeal carcinoma and other hematologic cancers, like Hodgkin's lymphoma, Burkitt's lymphoma (BL), B-cell immunoblastic lymphoma in HIV patients, and posttransplant-associated lymphoproliferative diseases.  EBV has the unique ability to establish life-long latent infection in primary human B lymphocytes. During latent infection, EBV expresses a small subset of genes, including 6 nuclear antigens (EBNA-1, -2, -3A, -3B, -3C, and -LP), 3 latent membrane proteins (LMP-1, -2A, and -2B), 2 small noncoding RNAs (EBER-1 and 2). On the basis of these latent gene expression, three different latency patterns associated with the types of cancers are recognized.
Class
Human Diseases; Infectious disease: viral
Pathway map
elk05169  Epstein-Barr virus infection
elk05169

Organism
Enhydra lutris kenyoni (northern sea otter) [GN:elk]
Gene
111151001  complement receptor type 2 isoform X1 [KO:K04012]
111162308  B-lymphocyte antigen CD19 isoform X1 [KO:K06465]
111152451  LOW QUALITY PROTEIN: RLA class II histocompatibility antigen, DP alpha-1 chain [KO:K06752]
111152452  HLA class II histocompatibility antigen, DP beta 1 chain-like [KO:K06752]
111152151  SLA class II histocompatibility antigen, DQ haplotype C beta chain-like [KO:K06752]
111152158  SLA class II histocompatibility antigen, DQ haplotype D alpha chain-like isoform X1 [KO:K06752]
111152168  HLA class II histocompatibility antigen, DM beta chain [KO:K06752]
111152169  HLA class II histocompatibility antigen, DM alpha chain [KO:K06752]
111152175  SLA class II histocompatibility antigen, DQ haplotype D alpha chain-like isoform X1 [KO:K06752]
111152178  LOW QUALITY PROTEIN: DLA class II histocompatibility antigen, DR-1 beta chain-like [KO:K06752]
111152191  HLA class II histocompatibility antigen, DO beta chain isoform X1 [KO:K06752]
111152200  HLA class II histocompatibility antigen, DR alpha chain [KO:K06752]
111152259  DLA class II histocompatibility antigen, DR-1 beta chain isoform X1 [KO:K06752]
111152356  HLA class II histocompatibility antigen, DQ beta 1 chain isoform X1 [KO:K06752]
111152358  LOW QUALITY PROTEIN: HLA class II histocompatibility antigen, DR alpha chain-like [KO:K06752]
111152383  HLA class II histocompatibility antigen, DO alpha chain [KO:K06752]
111154734  toll-like receptor 2 [KO:K10159]
111159049  myeloid differentiation primary response protein MyD88 [KO:K04729]
111157836  interleukin-1 receptor-associated kinase 4 isoform X1 [KO:K04733] [EC:2.7.11.1]
111139109  interleukin-1 receptor-associated kinase 1 isoform X1 [KO:K04730] [EC:2.7.11.1]
111150027  TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
111157505  TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 [KO:K04403]
111147521  TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 [KO:K04404]
111158801  mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
111144921  inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
111144397  inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
111139191  NF-kappa-B essential modulator [KO:K07210]
111140276  NF-kappa-B inhibitor alpha isoform X1 [KO:K04734]
111153611  nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
111149956  transcription factor p65 [KO:K04735]
111152248  tumor necrosis factor isoform X1 [KO:K03156]
111147365  interleukin-6 isoform X1 [KO:K05405]
111146203  LOW QUALITY PROTEIN: probable ATP-dependent RNA helicase DDX58 [KO:K12646] [EC:5.6.2.6]
111141602  mitochondrial antiviral-signaling protein isoform X1 [KO:K12648]
111148495  TNF receptor-associated factor 3 isoform X1 [KO:K03174]
111142106  serine/threonine-protein kinase TBK1 isoform X1 [KO:K05410] [EC:2.7.11.10]
111151174  inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X1 [KO:K07211] [EC:2.7.11.10]
111150049  interferon regulatory factor 7 [KO:K09447]
111160645  interferon regulatory factor 3 isoform X1 [KO:K05411]
111140482  interferon alpha-1/2-like [KO:K05414]
111159856  interferon alpha-1/2-like [KO:K05414]
111159858  interferon alpha-1/2-like [KO:K05414]
111159859  interferon alpha-1/2-like [KO:K05414]
111159861  interferon alpha-1/2-like [KO:K05414]
111159862  interferon alpha-1/2-like [KO:K05414]
111156578  interferon alpha-2-like [KO:K05414]
111156593  interferon alpha-1/2-like [KO:K05414]
111156594  interferon alpha-1/2-like [KO:K05414]
111156604  interferon alpha-like [KO:K05414]
111140592  interferon alpha-1/2-like [KO:K05414]
111156606  interferon alpha-1/2-like [KO:K05414]
111156609  interferon alpha-1/2-like [KO:K05414]
111140329  interferon alpha-1/2-like [KO:K05414]
111140335  interferon alpha-1/2-like [KO:K05414]
111140336  interferon alpha-1/2-like [KO:K05414]
111156577  interferon beta [KO:K05415]
111155707  interferon alpha/beta receptor 1 [KO:K05130]
111155645  interferon alpha/beta receptor 2 isoform X1 [KO:K05131]
111142881  tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
111162402  non-receptor tyrosine-protein kinase TYK2 isoform X1 [KO:K11219] [EC:2.7.10.2]
111144592  signal transducer and activator of transcription 1-alpha/beta isoform X1 [KO:K11220]
111160141  signal transducer and activator of transcription 2 isoform X1 [KO:K11221]
111140721  interferon regulatory factor 9 isoform X1 [KO:K04693]
111158436  interferon-induced, double-stranded RNA-activated protein kinase [KO:K16195] [EC:2.7.11.1]
111156451  2'-5'-oligoadenylate synthase 1 [KO:K14216] [EC:2.7.7.84]
111156463  2'-5'-oligoadenylate synthase 3-like isoform X1 [KO:K14216] [EC:2.7.7.84]
111156464  2'-5'-oligoadenylate synthase 2-like [KO:K14216] [EC:2.7.7.84]
111149252  C-X-C motif chemokine 10 [KO:K12671]
111154860  ubiquitin-like protein ISG15 [KO:K12159]
111144883  tumor necrosis factor receptor superfamily member 6 [KO:K04390]
111149616  FAS-associated death domain protein [KO:K02373]
111141026  caspase-8 isoform X1 [KO:K04398] [EC:3.4.22.61]
111159768  BH3-interacting domain death agonist [KO:K04726]
111158508  bcl-2-like protein 11 isoform X1 [KO:K16341]
111154217  apoptosis regulator Bcl-2 [KO:K02161]
111160657  apoptosis regulator BAX isoform X1 [KO:K02159]
111152355  bcl-2 homologous antagonist/killer [KO:K14021]
111147305  cytochrome c isoform X1 [KO:K08738]
111142635  LOW QUALITY PROTEIN: cytochrome c, testis-specific-like [KO:K08738]
111141900  LOW QUALITY PROTEIN: uncharacterized protein LOC111141900 [KO:K08738]
111142091  apoptotic protease-activating factor 1 isoform X1 [KO:K02084]
111154673  caspase-9 isoform X1 [KO:K04399] [EC:3.4.22.62]
111144607  caspase-3 [KO:K02187] [EC:3.4.22.56]
111153962  T-cell surface glycoprotein CD3 epsilon chain isoform X1 [KO:K06451]
111153842  T-cell surface glycoprotein CD3 gamma chain [KO:K06452]
111153823  T-cell surface glycoprotein CD3 delta chain isoform X1 [KO:K06450]
111150748  T-cell surface glycoprotein CD3 zeta chain isoform X1 [KO:K06453]
111155299  26S proteasome regulatory subunit 7 [KO:K03061]
111148465  26S proteasome regulatory subunit 4 [KO:K03062]
111161514  26S proteasome regulatory subunit 6B isoform X1 [KO:K03063]
111139115  26S proteasome regulatory subunit 10B [KO:K03064]
111149577  26S proteasome regulatory subunit 6A isoform X1 [KO:K03065]
111158036  26S proteasome regulatory subunit 8 isoform X1 [KO:K03066]
111148031  26S proteasome non-ATPase regulatory subunit 2 isoform X1 [KO:K03028]
111143971  26S proteasome non-ATPase regulatory subunit 1 isoform X1 [KO:K03032]
111151573  26S proteasome non-ATPase regulatory subunit 3 [KO:K03033]
111158181  26S proteasome non-ATPase regulatory subunit 12 isoform X1 [KO:K03035]
111151359  26S proteasome non-ATPase regulatory subunit 11 [KO:K03036]
111144078  26S proteasome non-ATPase regulatory subunit 6 isoform X1 [KO:K03037]
111152968  26S proteasome non-ATPase regulatory subunit 7 [KO:K03038]
111149610  26S proteasome non-ATPase regulatory subunit 13 [KO:K03039]
111161952  26S proteasome non-ATPase regulatory subunit 4 isoform X1 [KO:K03029]
111140976  26S proteasome non-ATPase regulatory subunit 14 [KO:K03030]
111161550  26S proteasome non-ATPase regulatory subunit 8 isoform X1 [KO:K03031]
111141807  LOW QUALITY PROTEIN: proteasomal ubiquitin receptor ADRM1 [KO:K06691]
111147630  LOW QUALITY PROTEIN: 26S proteasome complex subunit SEM1 [KO:K10881]
111152176  antigen peptide transporter 1 [KO:K05653] [EC:7.4.2.14]
111152449  antigen peptide transporter 2 [KO:K05654] [EC:7.4.2.14]
111152353  tapasin [KO:K08058]
111158840  protein disulfide-isomerase A3 [KO:K08056] [EC:5.3.4.1]
111162396  calreticulin [KO:K08057]
111152501  HLA class I histocompatibility antigen, alpha chain G-like isoform X1 [KO:K06751]
111139664  LOW QUALITY PROTEIN: H-2 class I histocompatibility antigen, Q8 alpha chain-like [KO:K06751]
111152201  LOW QUALITY PROTEIN: DLA class I histocompatibility antigen, A9/A9 alpha chain-like [KO:K06751]
111152203  DLA class I histocompatibility antigen, A9/A9 alpha chain-like [KO:K06751]
111152204  DLA class I histocompatibility antigen, A9/A9 alpha chain-like isoform X1 [KO:K06751]
111152405  LOW QUALITY PROTEIN: HLA class I histocompatibility antigen, A-36 alpha chain [KO:K06751]
111140516  beta-2-microglobulin [KO:K08055]
111148651  SNW domain-containing protein 1 [KO:K06063]
111153299  paired amphipathic helix protein Sin3a [KO:K11644]
111142974  histone deacetylase 1 isoform X1 [KO:K06067] [EC:3.5.1.98]
111158262  histone deacetylase 2 isoform X1 [KO:K06067] [EC:3.5.1.98]
111156480  nuclear receptor corepressor 2 [KO:K06065]
111140941  histone deacetylase complex subunit SAP30L isoform X1 [KO:K19202]
111154505  histone deacetylase complex subunit SAP30 isoform X1 [KO:K19202]
111141529  corepressor interacting with RBPJ 1 [KO:K06066]
111141790  recombining binding protein suppressor of hairless-like protein [KO:K06053]
111148915  recombining binding protein suppressor of hairless isoform X1 [KO:K06053]
111155108  transcription factor HES-1 [KO:K06054]
111161863  low affinity immunoglobulin epsilon Fc receptor isoform X1 [KO:K06468]
111154611  runt-related transcription factor 3 isoform X1 [KO:K09279]
111146783  myc proto-oncogene protein [KO:K04377]
111155980  ubiquitin carboxyl-terminal hydrolase 7 isoform X1 [KO:K11838] [EC:3.4.19.12]
111142120  E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:2.3.2.27]
111161133  cellular tumor antigen p53 [KO:K04451]
111147618  cyclin-dependent kinase inhibitor 1 [KO:K06625]
111143201  growth arrest and DNA damage-inducible protein GADD45 alpha isoform X1 [KO:K04402]
111161789  growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
111153625  growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
111150113  DNA damage-binding protein 2 isoform X1 [KO:K10140]
111148313  DNA polymerase kappa [KO:K03511] [EC:2.7.7.7]
111150675  TNF receptor-associated factor 5 [KO:K09849]
111155003  LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
111147545  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
111154641  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
111143470  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
111155224  phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
111143790  phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
111161374  RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
111148765  RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
111150885  RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
111158123  mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
111160543  transcription factor RelB isoform X1 [KO:K09253]
111144738  nuclear factor NF-kappa-B p100 subunit isoform X1 [KO:K04469]
111152832  tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
111161594  NF-kappa-B inhibitor beta [KO:K02581]
111147725  NF-kappa-B inhibitor epsilon [KO:K05872]
111161210  dual specificity mitogen-activated protein kinase kinase 4 isoform X1 [KO:K04430] [EC:2.7.12.2]
111161723  dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
111144860  mitogen-activated protein kinase 8 [KO:K04440] [EC:2.7.11.24]
111158897  mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
111154016  mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
111145476  TNF receptor-associated factor 2-like [KO:K03173] [EC:2.3.2.27]
111146100  TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
111156712  receptor-interacting serine/threonine-protein kinase 1 [KO:K02861] [EC:2.7.11.1]
111139240  dual specificity mitogen-activated protein kinase kinase 3 [KO:K04432] [EC:2.7.12.2]
111158041  dual specificity mitogen-activated protein kinase kinase 6 isoform X1 [KO:K04433] [EC:2.7.12.2]
111152267  mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
111157625  mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
111157628  mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
111152183  mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
111143174  transcription factor AP-1 [KO:K04448]
111159131  ectonucleoside triphosphate diphosphohydrolase 3 [KO:K01510] [EC:3.6.1.5]
111146334  ectonucleoside triphosphate diphosphohydrolase 8 [KO:K01510] [EC:3.6.1.5]
111145332  ectonucleoside triphosphate diphosphohydrolase 1 isoform X1 [KO:K01510] [EC:3.6.1.5]
111141553  tumor necrosis factor receptor superfamily member 5 isoform X1 [KO:K03160]
111149480  LOW QUALITY PROTEIN: CD44 antigen [KO:K06256]
111162178  integrin alpha-L isoform X1 [KO:K05718]
111142848  lymphocyte function-associated antigen 3 isoform X1 [KO:K06492]
111162530  intercellular adhesion molecule 1 [KO:K06490]
111155495  vimentin [KO:K07606]
111147788  tumor necrosis factor alpha-induced protein 3 [KO:K11859] [EC:3.4.19.12]
111143876  tyrosine-protein kinase JAK3 isoform X1 [KO:K11218] [EC:2.7.10.2]
111151241  signal transducer and activator of transcription 3 isoform X1 [KO:K04692]
111155370  tyrosine-protein kinase Lyn isoform X1 [KO:K05854] [EC:2.7.10.2]
111153538  tyrosine-protein kinase SYK isoform X1 [KO:K05855] [EC:2.7.10.2]
111153271  E3 ubiquitin-protein ligase NEDD4 isoform X1 [KO:K10591] [EC:2.3.2.26]
111145636  ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
111159177  tyrosine-protein kinase BTK isoform X1 [KO:K07370] [EC:2.7.10.2]
111145374  B-cell linker protein isoform X1 [KO:K07371]
111152978  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 isoform X1 [KO:K05859] [EC:3.1.4.11]
111140933  S-phase kinase-associated protein 2 [KO:K03875]
111142072  cyclin-dependent kinase inhibitor 1B [KO:K06624]
111142115  cyclin-dependent kinase inhibitor 1B [KO:K06624]
111149458  G1/S-specific cyclin-D1 [KO:K04503]
111159766  G1/S-specific cyclin-D2 [KO:K10151]
111147855  G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
111160230  cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
111147246  cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
111154269  cyclin-A2 [KO:K06627]
111158563  cyclin-A1 [KO:K06627]
111161443  G1/S-specific cyclin-E1 isoform X1 [KO:K06626]
111146791  G1/S-specific cyclin-E2 [KO:K06626]
111160135  cyclin-dependent kinase 2 isoform X1 [KO:K02206] [EC:2.7.11.22]
111146911  retinoblastoma-associated protein [KO:K06618]
111141556  transcription factor E2F1 [KO:K17454]
111154729  transcription factor E2F2 isoform X1 [KO:K09389]
111138625  transcription factor E2F3 isoform X1 [KO:K06620]
Compound
C00076  Calcium cation
C01245  D-myo-Inositol 1,4,5-trisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:15510157
  Authors
Young LS, Rickinson AB.
  Title
Epstein-Barr virus: 40 years on.
  Journal
Nat Rev Cancer 4:757-68 (2004)
DOI:10.1038/nrc1452
Reference
PMID:21372216
  Authors
Saha A, Robertson ES
  Title
Epstein-Barr virus-associated B-cell lymphomas: pathogenesis and clinical outcomes.
  Journal
Clin Cancer Res 17:3056-63 (2011)
DOI:10.1158/1078-0432.CCR-10-2578
Reference
PMID:21429244
  Authors
Ning S
  Title
Innate immune modulation in EBV infection.
  Journal
Herpesviridae 2:1 (2011)
DOI:10.1186/2042-4280-2-1
Reference
PMID:28408983
  Authors
Stanfield BA, Luftig MA
  Title
Recent advances in understanding Epstein-Barr virus.
  Journal
F1000Res 6:386 (2017)
DOI:10.12688/f1000research.10591.1
Reference
PMID:24586164
  Authors
van Gent M, Braem SG, de Jong A, Delagic N, Peeters JG, Boer IG, Moynagh PN, Kremmer E, Wiertz EJ, Ovaa H, Griffin BD, Ressing ME
  Title
Epstein-Barr virus large tegument protein BPLF1 contributes to innate immune evasion through interference with toll-like receptor signaling.
  Journal
PLoS Pathog 10:e1003960 (2014)
DOI:10.1371/journal.ppat.1003960
Reference
PMID:23850008
  Authors
Rajsbaum R, Garcia-Sastre A
  Title
Viral evasion mechanisms of early antiviral responses involving regulation of ubiquitin pathways.
  Journal
Trends Microbiol 21:421-9 (2013)
DOI:10.1016/j.tim.2013.06.006
Reference
PMID:25704559
  Authors
Hoffmann HH, Schneider WM, Rice CM
  Title
Interferons and viruses: an evolutionary arms race of molecular interactions.
  Journal
Trends Immunol 36:124-38 (2015)
DOI:10.1016/j.it.2015.01.004
Reference
PMID:22110506
  Authors
Spender LC, Inman GJ
  Title
Inhibition of germinal centre apoptotic programmes by epstein-barr virus.
  Journal
Adv Hematol 2011:829525 (2011)
DOI:10.1155/2011/829525
Reference
PMID:23303627
  Authors
Fu Q, He C, Mao ZR
  Title
Epstein-Barr virus interactions with the Bcl-2 protein family and apoptosis in human tumor cells.
  Journal
J Zhejiang Univ Sci B 14:8-24 (2013)
DOI:10.1631/jzus.B1200189
Reference
PMID:29116588
  Authors
Wang Y, Banerjee S, Ding L, Cai C, Wei F, Cai Q
  Title
The regulatory role of protein phosphorylation in human gammaherpesvirus associated cancers.
  Journal
Virol Sin 32:357-368 (2017)
DOI:10.1007/s12250-017-4081-9
Reference
PMID:23435233
  Authors
Melchjorsen J
  Title
Learning from the messengers: innate sensing of viruses and cytokine regulation of immunity - clues for treatments and vaccines.
  Journal
Viruses 5:470-527 (2013)
DOI:10.3390/v5020470
Reference
PMID:19498380
  Authors
Hansen TH, Bouvier M
  Title
MHC class I antigen presentation: learning from viral evasion strategies.
  Journal
Nat Rev Immunol 9:503-13 (2009)
DOI:10.1038/nri2575
Reference
PMID:18977445
  Authors
Ressing ME, Horst D, Griffin BD, Tellam J, Zuo J, Khanna R, Rowe M, Wiertz EJ
  Title
Epstein-Barr virus evasion of CD8(+) and CD4(+) T cell immunity via concerted actions of multiple gene products.
  Journal
Semin Cancer Biol 18:397-408 (2008)
DOI:10.1016/j.semcancer.2008.10.008
Reference
PMID:21146386
  Authors
Horst D, Verweij MC, Davison AJ, Ressing ME, Wiertz EJ
  Title
Viral evasion of T cell immunity: ancient mechanisms offering new applications.
  Journal
Curr Opin Immunol 23:96-103 (2011)
DOI:10.1016/j.coi.2010.11.005
Reference
PMID:27886133
  Authors
Ghosh Roy S, Robertson ES, Saha A
  Title
Epigenetic Impact on EBV Associated B-Cell Lymphomagenesis.
  Journal
Biomolecules 6:E46 (2016)
DOI:10.3390/biom6040046
Reference
PMID:22249143
  Authors
Dawson CW, Port RJ, Young LS
  Title
The role of the EBV-encoded latent membrane proteins LMP1 and LMP2 in the pathogenesis of nasopharyngeal carcinoma (NPC).
  Journal
Semin Cancer Biol 22:144-53 (2012)
DOI:10.1016/j.semcancer.2012.01.004
Reference
PMID:25613730
  Authors
Cai Q, Chen K, Young KH
  Title
Epstein-Barr virus-positive T/NK-cell lymphoproliferative disorders.
  Journal
Exp Mol Med 47:e133 (2015)
DOI:10.1038/emm.2014.105
Reference
PMID:17601372
  Authors
Zheng H, Li LL, Hu DS, Deng XY, Cao Y
  Title
Role of Epstein-Barr virus encoded latent membrane protein 1 in the carcinogenesis of nasopharyngeal carcinoma.
  Journal
Cell Mol Immunol 4:185-96 (2007)
Reference
PMID:23793113
  Authors
Ersing I, Bernhardt K, Gewurz BE
  Title
NF-kappaB and IRF7 pathway activation by Epstein-Barr virus Latent Membrane Protein 1.
  Journal
Viruses 5:1587-606 (2013)
DOI:10.3390/v5061587
Reference
PMID:28835489
  Authors
Wang LW, Jiang S, Gewurz BE
  Title
Epstein-Barr Virus LMP1-Mediated Oncogenicity.
  Journal
J Virol 91:e01718-16 (2017)
DOI:10.1128/JVI.01718-16
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PMID:12740915
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Mori N, Morishita M, Tsukazaki T, Yamamoto N
  Title
Repression of Smad-dependent transforming growth factor-beta signaling by Epstein-Barr virus latent membrane protein 1 through nuclear factor-kappaB.
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Int J Cancer 105:661-8 (2003)
DOI:10.1002/ijc.11146
Reference
PMID:25873381
  Authors
Edwards RH, Marquitz AR, Raab-Traub N
  Title
Changes in expression induced by Epstein-Barr Virus LMP1-CTAR1: potential role of bcl3.
  Journal
MBio 6:e00441-15 (2015)
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Nat Rev Immunol 1:75-82 (2001)
DOI:10.1038/35095584
Reference
PMID:11669605
  Authors
Eliopoulos AG, Young LS
  Title
LMP1 structure and signal transduction.
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Semin Cancer Biol 11:435-44 (2001)
DOI:10.1006/scbi.2001.0410
Reference
PMID:14506283
  Authors
Holowaty MN, Sheng Y, Nguyen T, Arrowsmith C, Frappier L
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Protein interaction domains of the ubiquitin-specific protease, USP7/HAUSP.
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J Biol Chem 278:47753-61 (2003)
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PMID:25403939
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Nat Rev Clin Oncol 12:11-26 (2015)
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Human Oncoviruses and p53 Tumor Suppressor Pathway Deregulation at the Origin of Human Cancers.
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Cancers (Basel) 10:E213 (2018)
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Sato Y, Kamura T, Shirata N, Murata T, Kudoh A, Iwahori S, Nakayama S, Isomura H, Nishiyama Y, Tsurumi T
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Degradation of phosphorylated p53 by viral protein-ECS E3 ligase complex.
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PLoS Pathog 5:e1000530 (2009)
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Saha A, Murakami M, Kumar P, Bajaj B, Sims K, Robertson ES
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Epstein-Barr virus nuclear antigen 3C augments Mdm2-mediated p53 ubiquitination and degradation by deubiquitinating Mdm2.
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J Virol 83:4652-69 (2009)
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Epstein-Barr virus nuclear antigen 3C targets p53 and modulates its transcriptional and apoptotic activities.
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Virology 388:236-47 (2009)
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Future Virol 4:79-91 (2009)
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Adv Cancer Res 79:175-200 (2000)
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Epstein-Barr Virus-Associated Malignancies: Roles of Viral Oncoproteins in Carcinogenesis.
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Front Oncol 8:265 (2018)
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Epstein-Barr virus: induction and control of cell transformation.
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J Cell Physiol 196:207-18 (2003)
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Reference
PMID:21347341
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Saha A, Halder S, Upadhyay SK, Lu J, Kumar P, Murakami M, Cai Q, Robertson ES
  Title
Epstein-Barr virus nuclear antigen 3C facilitates G1-S transition by stabilizing and enhancing the function of cyclin D1.
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PLoS Pathog 7:e1001275 (2011)
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Related
pathway
elk03050  Proteasome
elk04010  MAPK signaling pathway
elk04020  Calcium signaling pathway
elk04064  NF-kappa B signaling pathway
elk04110  Cell cycle
elk04115  p53 signaling pathway
elk04210  Apoptosis
elk04612  Antigen processing and presentation
elk04620  Toll-like receptor signaling pathway
elk04622  RIG-I-like receptor signaling pathway
elk04630  JAK-STAT signaling pathway
elk04662  B cell receptor signaling pathway
KO pathway
ko05169   
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