KEGG   PATHWAY: mmea04010
Entry
mmea04010                   Pathway                                
Name
MAPK signaling pathway - Malurus melanocephalus (red-backed fairy wren)
Description
The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli.
Class
Environmental Information Processing; Signal transduction
Pathway map
mmea04010  MAPK signaling pathway
mmea04010

Disease
H02157  Short-rib thoracic dysplasia
Other DBs
GO: 0000165
Organism
Malurus melanocephalus (red-backed fairy wren) [GN:mmea]
Gene
130572173  MAP3K20; mitogen-activated protein kinase kinase kinase 20 isoform X1 [KO:K04424] [EC:2.7.11.25]
130572185  ATF2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
130572351  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 [KO:K04404]
130572395  [KO:K16342] [EC:3.1.1.4]
130572707  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
130572725  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
130572778  GDNF; glial cell line-derived neurotrophic factor isoform X1 [KO:K05452]
130572817  MRAS; ras-related protein M-Ras [KO:K07831]
130572822  MAP3K2; mitogen-activated protein kinase kinase kinase 2 isoform X1 [KO:K04420] [EC:2.7.11.25]
130572928  TEK; angiopoietin-1 receptor isoform X1 [KO:K05121] [EC:2.7.10.1]
130573039  RET; proto-oncogene tyrosine-protein kinase receptor Ret [KO:K05126] [EC:2.7.10.1]
130573112  MAPK8IP1; C-Jun-amino-terminal kinase-interacting protein 1 isoform X1 [KO:K04434]
130573114  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
130573168  MYD88; myeloid differentiation primary response protein MyD88 [KO:K04729]
130573170  [KO:K04421] [EC:2.7.11.25]
130573396  PLA2G4B; cytosolic phospholipase A2 beta isoform X1 [KO:K16342] [EC:3.1.1.4]
130573455  [KO:K16342] [EC:3.1.1.4]
130573463  STK4; serine/threonine-protein kinase 4 [KO:K04411]
130573476  [KO:K16342] [EC:3.1.1.4]
130573484  [KO:K16342] [EC:3.1.1.4]
130573491  [KO:K16342] [EC:3.1.1.4]
130573498  PLA2G4F; cytosolic phospholipase A2 zeta [KO:K16342] [EC:3.1.1.4]
130573555  ANGPT4; angiopoietin-4 [KO:K05467]
130573609  IRAK4; interleukin-1 receptor-associated kinase 4 [KO:K04733] [EC:2.7.11.1]
130573676  STK3; serine/threonine-protein kinase 3 isoform X1 [KO:K04412]
130573878  FLT3; receptor-type tyrosine-protein kinase FLT3 [KO:K05092] [EC:2.7.10.1]
130573887  FLT1; vascular endothelial growth factor receptor 1 isoform X1 [KO:K05096] [EC:2.7.10.1]
130573943  PDGFRA; platelet-derived growth factor receptor alpha isoform X1 [KO:K04363] [EC:2.7.10.1]
130573948  KIT; mast/stem cell growth factor receptor Kit [KO:K05091] [EC:2.7.10.1]
130573949  KDR; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
130573960  MAP3K9; mitogen-activated protein kinase kinase kinase 9 isoform X1 [KO:K04417] [EC:2.7.11.25]
130574004  RASA2; ras GTPase-activating protein 2 isoform X1 [KO:K08053]
130574346  EFNA5; ephrin-A5 [KO:K05462]
130574656  CACNA2D2; voltage-dependent calcium channel subunit alpha-2/delta-2 [KO:K04859]
130574672  MAPKAPK3; MAP kinase-activated protein kinase 3 [KO:K04444] [EC:2.7.11.1]
130574922  MAP3K21; mitogen-activated protein kinase kinase kinase 21 isoform X1 [KO:K17534] [EC:2.7.11.25]
130574968  FGF9; fibroblast growth factor 9 [KO:K04358]
130574989  MYC; myc proto-oncogene protein [KO:K04377]
130575162  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
130575166  CACNG4; voltage-dependent calcium channel gamma-4 subunit [KO:K04869]
130575168  CACNG1; voltage-dependent calcium channel gamma-1 subunit [KO:K04866]
130575170  CACNG5; voltage-dependent calcium channel gamma-5 subunit [KO:K04870]
130575269  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
130575387  PTPN5; tyrosine-protein phosphatase non-receptor type 5 [KO:K18018] [EC:3.1.3.48]
130575524  [KO:K04386]
130575648  RRAS2; ras-related protein R-Ras2 [KO:K07830]
130575698  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 isoform X1 [KO:K04432] [EC:2.7.12.2]
130575727  GNA12; guanine nucleotide-binding protein subunit alpha-12 [KO:K04346]
130575776  FGF7; fibroblast growth factor 7 isoform X1 [KO:K04358]
130575834  NTRK2; BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
130575840  RASGRP3; ras guanyl-releasing protein 3 isoform X1 [KO:K12362]
130575916  [KO:K05096] [EC:2.7.10.1]
130575920  FGF16; fibroblast growth factor 16 [KO:K04358]
130575925  [KO:K04409] [EC:2.7.11.1]
130575942  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
130576007  MAP3K4; mitogen-activated protein kinase kinase kinase 4 isoform X1 [KO:K04428] [EC:2.7.11.25]
130576048  JUN; transcription factor Jun [KO:K04448]
130576123  KRAS; GTPase KRas isoform X1 [KO:K07827]
130576147  RPS6KA2; ribosomal protein S6 kinase alpha-2 [KO:K04373] [EC:2.7.11.1]
130576162  RPS6KA5; ribosomal protein S6 kinase alpha-5 isoform X1 [KO:K04445] [EC:2.7.11.1]
130576234  EGF; pro-epidermal growth factor [KO:K04357]
130576292  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
130576365  FAS; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
130576378  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
130576488  CACNG3; voltage-dependent calcium channel gamma-3 subunit isoform X1 [KO:K04868]
130576489  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
130576649  HRAS; GTPase HRas [KO:K02833]
130576857  FGF10; fibroblast growth factor 10 [KO:K04358]
130576967  TAOK1; serine/threonine-protein kinase TAO1 isoform X1 [KO:K04429] [EC:2.7.11.1]
130577059  IGF2; insulin-like growth factor II [KO:K13769]
130577067  DUSP8; dual specificity protein phosphatase 8 isoform X1 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
130577075  INS; insulin [KO:K04526]
130577124  MAP2K5; dual specificity mitogen-activated protein kinase kinase 5 [KO:K04463] [EC:2.7.12.2]
130577141  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
130577415  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
130577559  FGF19; fibroblast growth factor 19 [KO:K22603]
130577560  FGF3; fibroblast growth factor 3 [KO:K04358]
130577561  FGF4; fibroblast growth factor 4 [KO:K04358]
130577764  HSPB1; heat shock protein beta-1 [KO:K04455]
130577815  CACNA2D3; voltage-dependent calcium channel subunit alpha-2/delta-3 [KO:K04860]
130577827  DUSP16; dual specificity protein phosphatase 16 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
130577953  MAPK9; mitogen-activated protein kinase 9 [KO:K04440] [EC:2.7.11.24]
130577986  PGF; placenta growth factor isoform X1 [KO:K16859]
130578027  CRKL; crk-like protein [KO:K04438]
130578096  TRAF6; TNF receptor-associated factor 6 isoform X1 [KO:K03175] [EC:2.3.2.27]
130578156  FGFR3; fibroblast growth factor receptor 3 [KO:K05094] [EC:2.7.10.1]
130578235  MAP3K8; mitogen-activated protein kinase kinase kinase 8 [KO:K04415] [EC:2.7.11.25]
130578261  TAOK3; serine/threonine-protein kinase TAO3 isoform X1 [KO:K04429] [EC:2.7.11.1]
130578420  BRAF; serine/threonine-protein kinase B-raf [KO:K04365] [EC:2.7.11.1]
130578619  DUSP7; dual specificity protein phosphatase 7 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
130578627  MAP4K4; mitogen-activated protein kinase kinase kinase kinase 4 isoform X1 [KO:K04407] [EC:2.7.11.1]
130578641  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
130578691  [KO:K04852]
130578704  FOS; protein c-Fos [KO:K04379]
130578777  VEGFD; vascular endothelial growth factor D [KO:K05449]
130578791  NFKB2; nuclear factor NF-kappa-B p100 subunit [KO:K04469]
130578814  FGF20; fibroblast growth factor 20 [KO:K04358]
130578832  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
130578859  NRAS; GTPase NRas [KO:K07828]
130578868  NGF; beta-nerve growth factor [KO:K02582]
130578882  PDGFC; platelet-derived growth factor C [KO:K05450]
130578883  CSF1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453]
130578912  IGF1R; insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
130578931  DUSP4; dual specificity protein phosphatase 4 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
130579047  RAPGEF2; rap guanine nucleotide exchange factor 2 isoform X1 [KO:K08018]
130579048  DUSP5; dual specificity protein phosphatase 5 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
130579175  ANGPT1; angiopoietin-1 [KO:K05465]
130579221  TGFB3; transforming growth factor beta-3 proprotein [KO:K13377]
130579254  ANGPT2; angiopoietin-2 isoform X1 [KO:K05466]
130579320  RASGRP1; RAS guanyl-releasing protein 1 isoform X1 [KO:K04350]
130579332  PDGFRB; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
130579333  CSF1R; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
130579339  FLT4; vascular endothelial growth factor receptor 3 [KO:K05097] [EC:2.7.10.1]
130579402  RPS6KA6; ribosomal protein S6 kinase alpha-6 isoform X1 [KO:K04373] [EC:2.7.11.1]
130579715  [KO:K04388] [EC:2.7.11.30]
130579757  [KO:K05866] [EC:3.1.3.48]
130579834  CACNA2D1; voltage-dependent calcium channel subunit alpha-2/delta-1 isoform X1 [KO:K04858]
130579835  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
130579848  DUSP10; dual specificity protein phosphatase 10 [KO:K20216] [EC:3.1.3.16 3.1.3.48]
130579892  ARRB1; beta-arrestin-1 isoform X1 [KO:K04439]
130579901  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
130579961  FGF2; fibroblast growth factor 2 [KO:K18497]
130580110  RAP1B; ras-related protein Rap-1b [KO:K07836]
130580180  FGF22; fibroblast growth factor 22 isoform X1 [KO:K04358]
130580213  EFNA2; ephrin-A2 [KO:K05462]
130580322  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
130580403  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
130580499  MAPKAPK5; MAP kinase-activated protein kinase 5 isoform X1 [KO:K04442] [EC:2.7.11.1]
130580587  PTPRR; receptor-type tyrosine-protein phosphatase R [KO:K04458] [EC:3.1.3.48]
130580755  MECOM; histone-lysine N-methyltransferase MECOM isoform X1 [KO:K04462] [EC:2.1.1.367]
130580785  FGFR4; fibroblast growth factor receptor 4 isoform X1 [KO:K05095] [EC:2.7.10.1]
130580863  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 isoform X1 [KO:K04430] [EC:2.7.12.2]
130580941  MAPK11; mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
130580960  MAPK12; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
130581119  TGFBR1; TGF-beta receptor type-1 [KO:K04674] [EC:2.7.11.30]
130581270  MAP3K5; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
130581347  CACNA1G; voltage-dependent T-type calcium channel subunit alpha-1G [KO:K04854]
130581367  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
130581370  NF1; neurofibromin [KO:K08052]
130581372  NLK; serine/threonine-protein kinase NLK [KO:K04468] [EC:2.7.11.24]
130581475  DUSP3; dual specificity protein phosphatase 3 [KO:K17614] [EC:3.1.3.16 3.1.3.48]
130581482  MAP3K13; mitogen-activated protein kinase kinase kinase 13 [KO:K04422] [EC:2.7.11.25]
130581501  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
130581570  FGF18; fibroblast growth factor 18 isoform X1 [KO:K04358]
130581575  [KO:K22428]
130581589  BDNF; brain-derived neurotrophic factor isoform X1 [KO:K04355]
130581740  TGFBR2; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
130581835  EPHA2; LOW QUALITY PROTEIN: ephrin type-A receptor 2 [KO:K05103] [EC:2.7.10.1]
130581871  FGF8; fibroblast growth factor 8 [KO:K04358]
130581995  RAC3; ras-related C3 botulinum toxin substrate 3 [KO:K07861]
130582230  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
130582338  PAK2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
130582408  [KO:K04467] [EC:2.7.11.10]
130582443  DUSP6; dual specificity protein phosphatase 6 [KO:K21946] [EC:3.1.3.16 3.1.3.48]
130582452  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
130582463  MAP3K3; mitogen-activated protein kinase kinase kinase 3 [KO:K04421] [EC:2.7.11.25]
130582505  PPM1A; protein phosphatase 1A isoform X1 [KO:K04457] [EC:3.1.3.16]
130582587  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
130582849  MEF2C; myocyte-specific enhancer factor 2C isoform X1 [KO:K04454]
130582869  AREG; amphiregulin [KO:K09782]
130582873  EREG; proepiregulin isoform X1 [KO:K09784]
130582900  RASA1; ras GTPase-activating protein 1 [KO:K04352]
130582944  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
130583072  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
130583111  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
130583244  FGF5; fibroblast growth factor 5 [KO:K04358]
130583287  RPS6KA1; ribosomal protein S6 kinase alpha-1 [KO:K04373] [EC:2.7.11.1]
130583306  STMN1; stathmin [KO:K04381]
130583414  FGF1; fibroblast growth factor 1 [KO:K18496]
130583445  MAPK8IP3; C-Jun-amino-terminal kinase-interacting protein 3 isoform X1 [KO:K04436]
130583662  MAP3K14; mitogen-activated protein kinase kinase kinase 14 isoform X1 [KO:K04466] [EC:2.7.11.25]
130583675  PPP3R1; calcineurin subunit B type 1 isoform X1 [KO:K06268]
130583782  KITLG; kit ligand isoform X1 [KO:K05461]
130583790  SOS2; son of sevenless homolog 2 [KO:K03099]
130583904  CACNB2; voltage-dependent L-type calcium channel subunit beta-2 isoform X1 [KO:K04863]
130583968  RASGRF2; ras-specific guanine nucleotide-releasing factor 2 isoform X1 [KO:K12326]
130584144  CACNB3; voltage-dependent L-type calcium channel subunit beta-3 isoform X1 [KO:K04864]
130584174  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 [KO:K04433] [EC:2.7.12.2]
130584261  NFKB1; nuclear factor NF-kappa-B p105 subunit [KO:K02580]
130584323  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
130584324  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
130584332  IL1RAP; interleukin-1 receptor accessory protein isoform X1 [KO:K04723]
130584481  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
130584495  MKNK2; MAP kinase-interacting serine/threonine-protein kinase 2 isoform X1 [KO:K04372] [EC:2.7.11.1]
130584538  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform [KO:K04348] [EC:3.1.3.16]
130584560  PPM1B; protein phosphatase 1B isoform X1 [KO:K04461] [EC:3.1.3.16]
130584583  TRAF2; TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
130584616  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
130584667  EFNA3; ephrin-A3 isoform X1 [KO:K05462]
130584674  NTRK1; high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
130584678  [KO:K05462]
130584680  EFNA1; ephrin-A1 [KO:K05462]
130584721  PTPN7; tyrosine-protein phosphatase non-receptor type 7 [KO:K18019] [EC:3.1.3.48]
130584776  GADD45G; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
130584781  PPP3CA; protein phosphatase 3 catalytic subunit alpha isoform X1 [KO:K04348] [EC:3.1.3.16]
130584862  CACNA1H; voltage-dependent T-type calcium channel subunit alpha-1H [KO:K04855]
130584903  MAP4K3; mitogen-activated protein kinase kinase kinase kinase 3 isoform X1 [KO:K04406] [EC:2.7.11.1]
130584910  SOS1; son of sevenless homolog 1 [KO:K03099]
130584971  PLA2G4A; cytosolic phospholipase A2 isoform X1 [KO:K16342] [EC:3.1.1.4]
130585207  NTF3; neurotrophin-3 [KO:K04356]
130585262  [KO:K04407] [EC:2.7.11.1]
130585266  [KO:K04519]
130585309  VEGFC; vascular endothelial growth factor C [KO:K05449]
130585490  GADD45A; growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402]
130585491  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
130585531  INSR; insulin receptor [KO:K04527] [EC:2.7.10.1]
130585550  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
130585611  RASGRF1; ras-specific guanine nucleotide-releasing factor 1 isoform X1 [KO:K04349]
130585664  TGFB2; transforming growth factor beta-2 proprotein [KO:K13376]
130585692  LAMTOR3; ragulator complex protein LAMTOR3 [KO:K04370]
130585841  CACNB4; voltage-dependent L-type calcium channel subunit beta-4 isoform X1 [KO:K04865]
130585967  [KO:K05459]
130585971  ERBB2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
130586108  RAP1A; ras-related protein Rap-1A [KO:K04353]
130586133  SRF; serum response factor [KO:K04378]
130586163  CRK; adapter molecule crk isoform X1 [KO:K04438]
130586240  MAPT; microtubule-associated protein tau isoform X1 [KO:K04380]
130586277  PSPN; persephin [KO:K25416]
130586282  RPS6KA3; ribosomal protein S6 kinase alpha-3 [KO:K04373] [EC:2.7.11.1]
130586317  NR4A1; nuclear receptor subfamily 4 group A member 1 [KO:K04465]
130586349  FGF6; fibroblast growth factor 6 [KO:K04358]
130586629  CACNG2; voltage-dependent calcium channel gamma-2 subunit isoform X1 [KO:K04867]
130586654  JUND; transcription factor JunD [KO:K04449]
130586710  PPP5C; LOW QUALITY PROTEIN: serine/threonine-protein phosphatase 5 [KO:K04460] [EC:3.1.3.16]
130586751  GADD45B; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
130586756  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
130586797  HSPA8; heat shock cognate 71 kDa protein [KO:K03283]
130586864  RAC2; ras-related C3 botulinum toxin substrate 2 isoform X1 [KO:K07860]
130586910  DUSP1; dual specificity protein phosphatase 1 isoform X1 [KO:K21278] [EC:3.1.3.16 3.1.3.48]
130586920  FLT3LG; fms-related tyrosine kinase 3 ligand isoform X1 [KO:K05454]
130586993  ELK4; ETS domain-containing protein Elk-4 [KO:K04376]
130587039  [KO:K04443] [EC:2.7.11.1]
130587072  [KO:K04853]
130587083  [KO:K04431] [EC:2.7.12.2]
130587222  MAP3K12; mitogen-activated protein kinase kinase kinase 12 [KO:K04423] [EC:2.7.11.25]
130587369  CACNB1; voltage-dependent L-type calcium channel subunit beta-1 isoform X1 [KO:K04862]
130587526  [KO:K04435]
130587587  [KO:K04456] [EC:2.7.11.1]
130587662  PDGFB; platelet-derived growth factor subunit B [KO:K17386]
130587694  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform X1 [KO:K04403]
130587762  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
130587779  MAPK7; mitogen-activated protein kinase 7 [KO:K04464] [EC:2.7.11.24]
130587785  CACNA1I; voltage-dependent T-type calcium channel subunit alpha-1I isoform X1 [KO:K04856]
130587935  [KO:K04872]
130588477  [KO:K03156]
130588760  MAP3K1; mitogen-activated protein kinase kinase kinase 1 isoform X1 [KO:K04416] [EC:2.7.11.25]
130588799  VEGFA; vascular endothelial growth factor A isoform X1 [KO:K05448]
130588807  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
130588881  ERBB4; receptor tyrosine-protein kinase erbB-4 [KO:K05085] [EC:2.7.10.1]
130588985  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C [KO:K04850]
130588986  CACNA2D4; voltage-dependent calcium channel subunit alpha-2/delta-4 [KO:K04861]
130589230  MET; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
130589267  MKNK1; MAP kinase-interacting serine/threonine-protein kinase 1 isoform X1 [KO:K04372] [EC:2.7.11.1]
130589320  ARTN; artemin [KO:K25415]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00338  Lipopolysaccharide
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
Reference
PMID:11749383
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Chen Z, Gibson TB, Robinson F, Silvestro L, Pearson G, Xu B, Wright A, Vanderbilt C, Cobb MH.
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MAP kinases.
  Journal
Chem Rev 101:2449-76 (2001)
DOI:10.1021/cr000241p
Reference
PMID:12191611
  Authors
Tanoue T, Nishida E.
  Title
Docking interactions in the mitogen-activated protein kinase cascades.
  Journal
Pharmacol Ther 93:193-202 (2002)
DOI:10.1016/S0163-7258(02)00188-2
Reference
PMID:12947395
  Authors
Dent P, Yacoub A, Fisher PB, Hagan MP, Grant S.
  Title
MAPK pathways in radiation responses.
  Journal
Oncogene 22:5885-96 (2003)
DOI:10.1038/sj.onc.1206701
Reference
PMID:12676795
  Authors
Huang EJ, Reichardt LF.
  Title
Trk receptors: roles in neuronal signal transduction.
  Journal
Annu Rev Biochem 72:609-42 (2003)
DOI:10.1146/annurev.biochem.72.121801.161629
Reference
PMID:11369511
  Authors
Harper SJ, LoGrasso P.
  Title
Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38.
  Journal
Cell Signal 13:299-310 (2001)
DOI:10.1016/S0898-6568(01)00148-6
Reference
PMID:12390245
  Authors
Takeda K, Ichijo H
  Title
Neuronal p38 MAPK signalling: an emerging regulator of cell fate and function in the nervous system.
  Journal
Genes Cells 7:1099-111 (2002)
DOI:10.1046/j.1365-2443.2002.00591.x
Reference
PMID:14597384
  Authors
Yang SH, Sharrocks AD, Whitmarsh AJ.
  Title
Transcriptional regulation by the MAP kinase signaling cascades.
  Journal
Gene 320:3-21 (2003)
DOI:10.1016/S0378-1119(03)00816-3
Reference
PMID:12566928
  Authors
Zhu X, Lee HG, Raina AK, Perry G, Smith MA.
  Title
The role of mitogen-activated protein kinase pathways in Alzheimer's disease.
  Journal
Neurosignals 11:270-81 (2002)
DOI:10.1159/000067426
Reference
PMID:12849693
  Authors
Cho H, Lee J, Kwak NJ, Lee KH, Rha S, Kim YH, Cho YY, Yang KH, Kim K, Lim Y.
  Title
Silica induces nuclear factor-kappaB activation through TAK1 and NIK in Rat2 cell line.
  Journal
Toxicol Lett 143:323-30 (2003)
DOI:10.1016/S0378-4274(03)00193-0
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Reference
PMID:23085193
  Authors
Chu WM
  Title
Tumor necrosis factor.
  Journal
Cancer Lett 328:222-5 (2013)
DOI:10.1016/j.canlet.2012.10.014
Reference
PMID:22296764
  Authors
Newton K, Dixit VM
  Title
Signaling in innate immunity and inflammation.
  Journal
Cold Spring Harb Perspect Biol 4:a006049 (2012)
DOI:10.1101/cshperspect.a006049
Reference
PMID:19483709
  Authors
Gaestel M, Kotlyarov A, Kracht M
  Title
Targeting innate immunity protein kinase signalling in inflammation.
  Journal
Nat Rev Drug Discov 8:480-99 (2009)
DOI:10.1038/nrd2829
Reference
PMID:23664135
  Authors
Ajibade AA, Wang HY, Wang RF
  Title
Cell type-specific function of TAK1 in innate immune signaling.
  Journal
Trends Immunol 34:307-16 (2013)
DOI:10.1016/j.it.2013.03.007
Reference
PMID:24892271
  Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
  Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
  Journal
Biochim Biophys Acta 1843:2563-2582 (2014)
DOI:10.1016/j.bbamcr.2014.05.014
Related
pathway
mmea04070  Phosphatidylinositol signaling system
mmea04110  Cell cycle
mmea04115  p53 signaling pathway
mmea04210  Apoptosis
mmea04310  Wnt signaling pathway
KO pathway
ko04010   

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