KEGG   PATHWAY: ocu04622
Entry
ocu04622                    Pathway                                
Name
RIG-I-like receptor signaling pathway - Oryctolagus cuniculus (rabbit)
Description
Specific families of pattern recognition receptors are responsible for detecting viral pathogens and generating innate immune responses. Non-self RNA appearing in a cell as a result of intracellular viral replication is recognized by a family of cytosolic RNA helicases termed RIG-I-like receptors (RLRs). The RLR proteins include RIG-I, MDA5, and LGP2 and are expressed in both immune and nonimmune cells. Upon recognition of viral nucleic acids, RLRs recruit specific intracellular adaptor proteins to initiate signaling pathways that lead to the synthesis of type I interferon and other inflammatory cytokines, which are important for eliminating viruses.
Class
Organismal Systems; Immune system
Pathway map
ocu04622  RIG-I-like receptor signaling pathway
ocu04622

Organism
Oryctolagus cuniculus (rabbit) [GN:ocu]
Gene
100347707  RIGI; antiviral innate immune response receptor RIG-I isoform X1 [KO:K12646] [EC:5.6.2.6]
100343560  interferon-induced helicase C domain-containing protein 1 [KO:K12647] [EC:5.6.2.6]
100350695  NFX1-type zinc finger-containing protein 1 [KO:K27391]
100356540  mitochondrial antiviral-signaling protein [KO:K12648]
100347525  ATP-dependent RNA helicase DHX58 [KO:K12649] [EC:5.6.2.6]
100359083  TNF receptor-associated factor 3 isoform X1 [KO:K03174]
100339142  TRAF family member-associated NF-kappa-B activator isoform X1 [KO:K12650]
100342816  5-azacytidine-induced protein 2 isoform X1 [KO:K12651]
100350523  TANK-binding kinase 1-binding protein 1 [KO:K12652]
100328905  IKBKG; NF-kappa-B essential modulator [KO:K07210]
100358771  serine/threonine-protein kinase TBK1 isoform X1 [KO:K05410] [EC:2.7.11.10]
100354455  inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X1 [KO:K07211] [EC:2.7.11.10]
103346571  interferon regulatory factor 3 isoform X1 [KO:K05411]
100353390  interferon alpha-21-like [KO:K05414]
100355669  interferon alpha-21-like [KO:K05414]
100355912  interferon alpha-5-like [KO:K05414]
100357708  interferon alpha-21-like isoform X2 [KO:K05414]
100354654  interferon alpha-21-like [KO:K05414]
100356419  interferon alpha-14-like [KO:K05414]
100357194  interferon alpha-21-like [KO:K05414]
100356678  interferon alpha-1/13 [KO:K05414]
100342931  interferon beta [KO:K05415]
100353137  interferon omega-1-like [KO:K05440]
100353640  interferon omega-1-like [KO:K05440]
100353888  interferon omega-1-like [KO:K05440]
100354910  interferon omega-1-like [KO:K05440]
100355421  interferon omega-1 [KO:K05440]
100358223  interferon omega-1 [KO:K05440]
100354397  interferon omega-1 [KO:K05440]
100357452  interferon omega-1-like [KO:K05440]
100341910  interferon epsilon [KO:K05442]
100348954  interferon kappa [KO:K05441]
100337888  tumor necrosis factor receptor type 1-associated DEATH domain protein isoform X2 [KO:K03171]
100352965  receptor-interacting serine/threonine-protein kinase 1 isoform X3 [KO:K02861] [EC:2.7.11.1]
100348477  caspase-8 [KO:K04398] [EC:3.4.22.61]
100101580  CASP10; caspase-10 [KO:K04400] [EC:3.4.22.63]
100355888  inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
100356401  inhibitor of nuclear factor kappa-B kinase subunit beta isoform X5 [KO:K07209] [EC:2.7.11.10]
100359283  NF-kappa-B inhibitor beta isoform X2 [KO:K02581]
100357341  NF-kappa-B inhibitor alpha [KO:K04734]
100349426  nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
127485184  transcription factor p65 isoform X1 [KO:K04735]
100343571  mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
100343190  TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
100348484  mitogen-activated protein kinase kinase kinase 1 isoform X1 [KO:K04416] [EC:2.7.11.25]
100346929  mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
100342664  mitogen-activated protein kinase 9 isoform X2 [KO:K04440] [EC:2.7.11.24]
100337999  mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
100350614  mitogen-activated protein kinase 12 isoform X2 [KO:K04441] [EC:2.7.11.24]
103346035  mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
100344161  mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
100341695  mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
100009129  CXCL8; interleukin-8 precursor [KO:K10030]
100009088  TNF; tumor necrosis factor precursor [KO:K03156]
100349007  interleukin-12 subunit alpha [KO:K05406]
100354852  interleukin-12 subunit beta [KO:K05425]
100353112  C-X-C motif chemokine 10 [KO:K12671]
100346984  double-stranded RNA-specific adenosine deaminase isoform X2 [KO:K12968] [EC:3.5.4.37]
100343500  E3 ubiquitin/ISG15 ligase TRIM25 [KO:K10652] [EC:2.3.2.27]
100354572  ubiquitin carboxyl-terminal hydrolase CYLD isoform X1 [KO:K08601] [EC:3.4.19.12]
127487650  LOW QUALITY PROTEIN: ubiquitin carboxyl-terminal hydrolase CYLD-like [KO:K08601] [EC:3.4.19.12]
100349404  E3 ubiquitin-protein ligase RNF125 [KO:K12170] [EC:2.3.2.27]
100342807  autophagy protein 5 isoform X2 [KO:K08339]
103347845  ubiquitin-like protein ATG12 isoform X1 [KO:K08336]
100346703  ubiquitin-like protein ATG12 [KO:K08336]
100341830  NLR family member X1 isoform X1 [KO:K12653]
100349135  STING1; stimulator of interferon genes protein isoform X1 [KO:K12654]
100346051  OTU domain-containing protein 5 isoform X2 [KO:K12655] [EC:3.4.19.12]
100343224  suppressor of IKBKE 1 isoform X1 [KO:K12656]
100348597  ATP-dependent RNA helicase DDX3X isoform X2 [KO:K11594] [EC:5.6.2.7]
103345715  peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 isoform X1 [KO:K09578] [EC:5.2.1.8]
100344187  triokinase/FMN cyclase [KO:K00863] [EC:2.7.1.28 2.7.1.29 4.6.1.15]
Compound
C00046  RNA
Reference
PMID:15208624
  Authors
Yoneyama M, Kikuchi M, Natsukawa T, Shinobu N, Imaizumi T, Miyagishi M, Taira K, Akira S, Fujita T
  Title
The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses.
  Journal
Nat Immunol 5:730-7 (2004)
DOI:10.1038/ni1087
Reference
PMID:18272355
  Authors
Takeuchi O, Akira S
  Title
MDA5/RIG-I and virus recognition.
  Journal
Curr Opin Immunol 20:17-22 (2008)
DOI:10.1016/j.coi.2008.01.002
Reference
PMID:19120475
  Authors
Yoneyama M, Fujita T
  Title
RNA recognition and signal transduction by RIG-I-like receptors.
  Journal
Immunol Rev 227:54-65 (2009)
DOI:10.1111/j.1600-065X.2008.00727.x
Reference
PMID:19539500
  Authors
Nakhaei P, Genin P, Civas A, Hiscott J
  Title
RIG-I-like receptors: sensing and responding to RNA virus infection.
  Journal
Semin Immunol 21:215-22 (2009)
DOI:10.1016/j.smim.2009.05.001
Reference
PMID:18549796
  Authors
Moore CB, Ting JP
  Title
Regulation of mitochondrial antiviral signaling pathways.
  Journal
Immunity 28:735-9 (2008)
DOI:10.1016/j.immuni.2008.05.005
Reference
PMID:19615405
  Authors
Barral PM, Sarkar D, Su ZZ, Barber GN, DeSalle R, Racaniello VR, Fisher PB
  Title
Functions of the cytoplasmic RNA sensors RIG-I and MDA-5: key regulators of innate immunity.
  Journal
Pharmacol Ther 124:219-34 (2009)
DOI:10.1016/j.pharmthera.2009.06.012
Reference
PMID:19120476
  Authors
Schlee M, Hartmann E, Coch C, Wimmenauer V, Janke M, Barchet W, Hartmann G
  Title
Approaching the RNA ligand for RIG-I?
  Journal
Immunol Rev 227:66-74 (2009)
DOI:10.1111/j.1600-065X.2008.00724.x
Reference
PMID:18591413
  Authors
Saito T, Gale M Jr
  Title
Differential recognition of double-stranded RNA by RIG-I-like receptors in antiviral immunity.
  Journal
J Exp Med 205:1523-7 (2008)
DOI:10.1084/jem.20081210
Reference
PMID:19076341
  Authors
Kawai T, Akira S
  Title
Toll-like receptor and RIG-I-like receptor signaling.
  Journal
Ann N Y Acad Sci 1143:1-20 (2008)
DOI:10.1196/annals.1443.020
Reference
PMID:18439848
  Authors
Michallet MC, Meylan E, Ermolaeva MA, Vazquez J, Rebsamen M, Curran J, Poeck H, Bscheider M, Hartmann G, Konig M, Kalinke U, Pasparakis M, Tschopp J
  Title
TRADD protein is an essential component of the RIG-like helicase antiviral pathway.
  Journal
Immunity 28:651-61 (2008)
DOI:10.1016/j.immuni.2008.03.013
Reference
PMID:18984593
  Authors
Yoshida R, Takaesu G, Yoshida H, Okamoto F, Yoshioka T, Choi Y, Akira S, Kawai T, Yoshimura A, Kobayashi T
  Title
TRAF6 and MEKK1 play a pivotal role in the RIG-I-like helicase antiviral pathway.
  Journal
J Biol Chem 283:36211-20 (2008)
DOI:10.1074/jbc.M806576200
Reference
PMID:19224920
  Authors
Mikkelsen SS, Jensen SB, Chiliveru S, Melchjorsen J, Julkunen I, Gaestel M, Arthur JS, Flavell RA, Ghosh S, Paludan SR
  Title
RIG-I-mediated activation of p38 MAPK is essential for viral induction of interferon and activation of dendritic cells: dependence on TRAF2 and TAK1.
  Journal
J Biol Chem 284:10774-82 (2009)
DOI:10.1074/jbc.M807272200
Reference
PMID:32668226
  Authors
Liu G, Gack MU
  Title
Distinct and Orchestrated Functions of RNA Sensors in Innate Immunity.
  Journal
Immunity 53:26-42 (2020)
DOI:10.1016/j.immuni.2020.03.017
Related
pathway
ocu04010  MAPK signaling pathway
ocu04120  Ubiquitin mediated proteolysis
ocu04210  Apoptosis
ocu04630  JAK-STAT signaling pathway
KO pathway
ko04622   
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