KEGG   PATHWAY: ocu04622
ocu04622                    Pathway                                
RIG-I-like receptor signaling pathway - Oryctolagus cuniculus (rabbit)
Specific families of pattern recognition receptors are responsible for detecting viral pathogens and generating innate immune responses. Non-self RNA appearing in a cell as a result of intracellular viral replication is recognized by a family of cytosolic RNA helicases termed RIG-I-like receptors (RLRs). The RLR proteins include RIG-I, MDA5, and LGP2 and are expressed in both immune and nonimmune cells. Upon recognition of viral nucleic acids, RLRs recruit specific intracellular adaptor proteins to initiate signaling pathways that lead to the synthesis of type I interferon and other inflammatory cytokines, which are important for eliminating viruses.
Organismal Systems; Immune system
Pathway map
ocu04622  RIG-I-like receptor signaling pathway

Oryctolagus cuniculus (rabbit) [GN:ocu]
100347707  DDX58; DExD/H-box helicase 58 [KO:K12646] [EC:]
100343560  IFIH1; interferon induced with helicase C domain 1 [KO:K12647] [EC:]
100356540  MAVS; mitochondrial antiviral signaling protein [KO:K12648]
100347525  DHX58; DExH-box helicase 58 [KO:K12649] [EC:]
100359083  TRAF3; TNF receptor associated factor 3 [KO:K03174]
100339142  TANK; TRAF family member associated NFKB activator [KO:K12650]
100342816  AZI2; 5-azacytidine induced 2 [KO:K12651]
100350523  TBKBP1; TBK1 binding protein 1 [KO:K12652]
100328905  IKBKG; inhibitor of nuclear factor kappa B kinase subunit gamma [KO:K07210]
100358771  TBK1; TANK binding kinase 1 [KO:K05410] [EC:]
100354455  IKBKE; inhibitor of nuclear factor kappa B kinase subunit epsilon [KO:K07211] [EC:]
103346571  IRF3; interferon regulatory factor 3 [KO:K05411]
100358763  IRF7; interferon regulatory factor 7 [KO:K09447]
100353390  interferon alpha-21-like [KO:K05414]
100355669  interferon alpha-21-like [KO:K05414]
100355912  interferon alpha-5-like [KO:K05414]
100357708  interferon alpha-21-like [KO:K05414]
100354654  interferon alpha-21-like [KO:K05414]
100356419  interferon alpha-14-like [KO:K05414]
100357194  interferon alpha-21-like [KO:K05414]
100356678  interferon alpha-1/13-like [KO:K05414]
100342931  IFNB1; interferon beta 1 [KO:K05415]
100353137  interferon omega-1-like [KO:K05440]
100353640  interferon omega-1-like [KO:K05440]
100353888  interferon omega-1-like [KO:K05440]
100354910  interferon omega-1-like [KO:K05440]
100355421  interferon omega-1-like [KO:K05440]
100358223  interferon omega-1-like [KO:K05440]
100354397  interferon omega-1-like [KO:K05440]
100356937  interferon omega-1-like [KO:K05440]
100357452  interferon omega-1-like [KO:K05440]
100341910  IFNE; interferon epsilon [KO:K05442]
100348954  IFNK; interferon kappa [KO:K05441]
100337888  TRADD; TNFRSF1A associated via death domain [KO:K03171]
103346753  FADD; Fas associated via death domain [KO:K02373]
100352965  RIPK1; receptor interacting serine/threonine kinase 1 [KO:K02861] [EC:]
100348477  CASP8; caspase 8 [KO:K04398] [EC:]
100101580  CASP10; caspase 10 [KO:K04400] [EC:]
100355888  CHUK; conserved helix-loop-helix ubiquitous kinase [KO:K04467] [EC:]
100356401  IKBKB; inhibitor of nuclear factor kappa B kinase subunit beta [KO:K07209] [EC:]
100359283  NFKBIB; NFKB inhibitor beta [KO:K02581]
100357341  NFKBIA; NFKB inhibitor alpha [KO:K04734]
100349426  NFKB1; nuclear factor kappa B subunit 1 [KO:K02580]
100343571  MAP3K7; mitogen-activated protein kinase kinase kinase 7 [KO:K04427] [EC:]
100343190  TRAF6; TNF receptor associated factor 6 [KO:K03175] [EC:]
100348484  MAP3K1; mitogen-activated protein kinase kinase kinase 1 [KO:K04416] [EC:]
100346929  MAPK8; mitogen-activated protein kinase 8 [KO:K04440] [EC:]
100342664  MAPK9; mitogen-activated protein kinase 9 [KO:K04440] [EC:]
100337999  MAPK10; mitogen-activated protein kinase 10 [KO:K04440] [EC:]
100350614  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:]
103346035  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:]
100344161  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:]
100341695  MAPK14; mitogen-activated protein kinase 14 [KO:K04441] [EC:]
100009129  CXCL8; C-X-C motif chemokine ligand 8 [KO:K10030]
100009088  TNF; tumor necrosis factor [KO:K03156]
100349007  IL12A; interleukin 12A [KO:K05406]
100354852  IL12B; interleukin 12B [KO:K05425]
100353112  CXCL10; C-X-C motif chemokine ligand 10 [KO:K12671]
100343500  TRIM25; tripartite motif containing 25 [KO:K10652] [EC:]
100354572  CYLD; CYLD lysine 63 deubiquitinase [KO:K08601] [EC:]
100349404  RNF125; ring finger protein 125 [KO:K12170] [EC:]
100354504  ISG15; ISG15 ubiquitin-like modifier [KO:K12159]
100342807  ATG5; autophagy related 5 [KO:K08339]
103347845  ATG12; autophagy related 12 [KO:K08336]
100346703  ubiquitin-like protein ATG12 [KO:K08336]
100341830  NLRX1; NLR family member X1 [KO:K12653]
100349135  TMEM173; transmembrane protein 173 [KO:K12654]
100346051  OTUD5; OTU deubiquitinase 5 [KO:K12655] [EC:]
100343224  SIKE1; suppressor of IKBKE 1 [KO:K12656]
100348597  DDX3X; DEAD-box helicase 3, X-linked [KO:K11594] [EC:]
103345715  PIN1; peptidylprolyl cis/trans isomerase, NIMA-interacting 1 [KO:K09578] [EC:]
100344187  TKFC; triokinase and FMN cyclase [KO:K00863] [EC:]
Yoneyama M, Kikuchi M, Natsukawa T, Shinobu N, Imaizumi T, Miyagishi M, Taira K, Akira S, Fujita T
The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses.
Nat Immunol 5:730-7 (2004)
Takeuchi O, Akira S
MDA5/RIG-I and virus recognition.
Curr Opin Immunol 20:17-22 (2008)
Yoneyama M, Fujita T
RNA recognition and signal transduction by RIG-I-like receptors.
Immunol Rev 227:54-65 (2009)
Nakhaei P, Genin P, Civas A, Hiscott J
RIG-I-like receptors: sensing and responding to RNA virus infection.
Semin Immunol 21:215-22 (2009)
Moore CB, Ting JP
Regulation of mitochondrial antiviral signaling pathways.
Immunity 28:735-9 (2008)
Barral PM, Sarkar D, Su ZZ, Barber GN, DeSalle R, Racaniello VR, Fisher PB
Functions of the cytoplasmic RNA sensors RIG-I and MDA-5: key regulators of innate immunity.
Pharmacol Ther 124:219-34 (2009)
Schlee M, Hartmann E, Coch C, Wimmenauer V, Janke M, Barchet W, Hartmann G
Approaching the RNA ligand for RIG-I?
Immunol Rev 227:66-74 (2009)
Saito T, Gale M Jr
Differential recognition of double-stranded RNA by RIG-I-like receptors in antiviral immunity.
J Exp Med 205:1523-7 (2008)
Kawai T, Akira S
Toll-like receptor and RIG-I-like receptor signaling.
Ann N Y Acad Sci 1143:1-20 (2008)
Michallet MC, Meylan E, Ermolaeva MA, Vazquez J, Rebsamen M, Curran J, Poeck H, Bscheider M, Hartmann G, Konig M, Kalinke U, Pasparakis M, Tschopp J
TRADD protein is an essential component of the RIG-like helicase antiviral pathway.
Immunity 28:651-61 (2008)
Yoshida R, Takaesu G, Yoshida H, Okamoto F, Yoshioka T, Choi Y, Akira S, Kawai T, Yoshimura A, Kobayashi T
TRAF6 and MEKK1 play a pivotal role in the RIG-I-like helicase antiviral pathway.
J Biol Chem 283:36211-20 (2008)
Mikkelsen SS, Jensen SB, Chiliveru S, Melchjorsen J, Julkunen I, Gaestel M, Arthur JS, Flavell RA, Ghosh S, Paludan SR
RIG-I-mediated activation of p38 MAPK is essential for viral induction of interferon and activation of dendritic cells: dependence on TRAF2 and TAK1.
J Biol Chem 284:10774-82 (2009)
ocu04010  MAPK signaling pathway
ocu04120  Ubiquitin mediated proteolysis
ocu04210  Apoptosis
ocu04630  JAK-STAT signaling pathway
KO pathway

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