KEGG   PATHWAY: ocu04630
Entry
ocu04630                    Pathway                                
Name
JAK-STAT signaling pathway - Oryctolagus cuniculus (rabbit)
Description
The Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeostasis in animals, from humans to flies. In mammals, the JAK/STAT pathway is the principal signaling mechanism for a wide array of cytokines and growth factors. Following the binding of cytokines to their cognate receptor, STATs are activated by members of the JAK family of tyrosine kinases. Once activated, they dimerize and translocate to the nucleus and modulate the expression of target genes. In addition to the activation of STATs, JAKs mediate the recruitment of other molecules such as the MAP kinases, PI3 kinase etc. These molecules process downstream signals via the Ras-Raf-MAP kinase and PI3 kinase pathways which results in the activation of additional transcription factors.
Class
Environmental Information Processing; Signal transduction
Pathway map
ocu04630  JAK-STAT signaling pathway
ocu04630

Other DBs
GO: 0007259
Organism
Oryctolagus cuniculus (rabbit) [GN:ocu]
Gene
100302458  IL2; interleukin 2 [KO:K05429]
100302454  IL4; interleukin 4 [KO:K05430]
100358075  IL5; interleukin 5 [KO:K05428]
100008733  IL6; interleukin 6 [KO:K05405]
100345409  IL7; interleukin 7 [KO:K05431]
100340820  IL9; interleukin 9 [KO:K05432]
100008701  IL10; interleukin 10 [KO:K05443]
100349007  IL12A; interleukin 12A [KO:K05406]
100354852  IL12B; interleukin 12B [KO:K05425]
100358676  IL13; interleukin 13 [KO:K05435]
100009017  IL15; interleukin 15 [KO:K05433]
103349030  IL17D; interleukin 17D [KO:K05492]
100353950  IL19; interleukin 19 [KO:K05444]
100353705  IL20; interleukin 20 [KO:K22667]
100344172  IL21; interleukin 21 [KO:K05434]
100348980  IL22; interleukin 22 [KO:K05445]
100352065  IL23A; interleukin 23 subunit alpha [KO:K05426]
100353390  interferon alpha-21-like [KO:K05414]
100355669  interferon alpha-21-like [KO:K05414]
100355912  interferon alpha-5-like [KO:K05414]
100357708  interferon alpha-21-like [KO:K05414]
100354654  interferon alpha-21-like [KO:K05414]
100356419  interferon alpha-14-like [KO:K05414]
100357194  interferon alpha-21-like [KO:K05414]
100356678  interferon alpha-1/13-like [KO:K05414]
100342931  IFNB1; interferon beta 1 [KO:K05415]
100008602  IFNG; interferon gamma [KO:K04687]
100341910  IFNE; interferon epsilon [KO:K05442]
100348954  IFNK; interferon kappa [KO:K05441]
100341420  interferon lambda-1-like [KO:K05447]
100353137  interferon omega-1-like [KO:K05440]
100353640  interferon omega-1-like [KO:K05440]
100353888  interferon omega-1-like [KO:K05440]
100354910  interferon omega-1-like [KO:K05440]
100355421  interferon omega-1-like [KO:K05440]
100358223  interferon omega-1-like [KO:K05440]
100354397  interferon omega-1-like [KO:K05440]
100356937  interferon omega-1-like [KO:K05440]
100357452  interferon omega-1-like [KO:K05440]
100342491  OSM; oncostatin M [KO:K05418]
100358914  LIF; leukemia inhibitory factor [KO:K05419]
103349580  TSLP; thymic stromal lymphopoietin [KO:K05436]
100354643  CTF1; cardiotrophin-1 [KO:K05422]
108175610  cardiotrophin-2 [KO:K24382]
100328720  CSF2; colony stimulating factor 2 [KO:K05427]
100009117  CNTF; ciliary neurotrophic factor [KO:K05420]
100356652  CSF3; colony stimulating factor 3 [KO:K05423]
100008786  EPO; erythropoietin [KO:K05437]
100356068  GH1; somatotropin [KO:K05438]
100008747  LEP; leptin [KO:K05424]
100357079  THPO; thrombopoietin [KO:K06854]
100009394  PRL; prolactin [KO:K05439]
100008808  EGF; epidermal growth factor [KO:K04357]
100352388  PDGFA; platelet derived growth factor subunit A [KO:K04359]
100358772  PDGFB; platelet derived growth factor subunit B [KO:K17386]
100358489  interleukin-2 receptor subunit alpha [KO:K05068]
100338113  interleukin-2 receptor subunit alpha [KO:K05068]
103351862  IL2RG; interleukin 2 receptor subunit gamma [KO:K05070]
103345135  IL3RA; interleukin 3 receptor subunit alpha [KO:K04737]
100337721  IL4R; interleukin 4 receptor [KO:K05071]
100347606  IL5RA; interleukin 5 receptor subunit alpha [KO:K05067]
100347752  IL6R; interleukin 6 receptor [KO:K05055]
100343726  IL7R; interleukin 7 receptor [KO:K05072]
100356855  IL9R; interleukin 9 receptor [KO:K05073]
100354902  IL10RA; interleukin 10 receptor subunit alpha [KO:K05134]
100338351  IL10RB; interleukin 10 receptor subunit beta [KO:K05135]
103351784  IL11RA; interleukin 11 receptor subunit alpha [KO:K05056]
100350416  IL12RB2; interleukin 12 receptor subunit beta 2 [KO:K05064]
100351788  IL13RA1; interleukin 13 receptor subunit alpha 1 [KO:K05076]
100348025  IL13RA2; interleukin 13 receptor subunit alpha 2 [KO:K05077]
100358749  interleukin-15 receptor subunit alpha [KO:K05074]
100359262  IL15RA; interleukin 15 receptor subunit alpha [KO:K05074]
100341271  IL20RA; interleukin 20 receptor subunit alpha [KO:K05136]
100349338  IL20RB; interleukin 20 receptor subunit beta [KO:K05137]
103348594  IL21R; interleukin 21 receptor [KO:K05075]
100344077  IL22RA1; interleukin 22 receptor subunit alpha 1 [KO:K05138]
100341531  IL22RA2; interleukin 22 receptor subunit alpha 2 [KO:K05139]
100350917  IL23R; interleukin 23 receptor [KO:K05065]
103347059  IL27RA; interleukin 27 receptor subunit alpha [KO:K19598]
100349330  IL6ST; interleukin 6 signal transducer [KO:K05060]
100338604  IFNAR1; interferon alpha and beta receptor subunit 1 [KO:K05130]
100338097  IFNAR2; interferon alpha and beta receptor subunit 2 [KO:K05131]
100341787  IFNGR1; interferon gamma receptor 1 [KO:K05132]
100338854  IFNGR2; interferon gamma receptor 2 [KO:K05133]
100356641  IFNLR1; interferon lambda receptor 1 [KO:K05140]
100356631  OSMR; oncostatin M receptor [KO:K05057]
100303762  LIFR; leukemia inhibitory factor receptor alpha [KO:K05058]
103352517  CRLF2; cytokine receptor-like factor 2 [KO:K05078]
100349367  CNTFR; ciliary neurotrophic factor receptor [KO:K05059]
100346676  CSF2RA; colony stimulating factor 2 receptor alpha subunit [KO:K05066]
100349996  CSF2RB; colony stimulating factor 2 receptor beta common subunit [KO:K04738]
100342746  CSF3R; colony stimulating factor 3 receptor [KO:K05061]
100355350  EPOR; erythropoietin receptor [KO:K05079]
100009325  GHR; growth hormone receptor [KO:K05080]
100351924  LEPR; leptin receptor [KO:K05062]
100355135  MPL; MPL proto-oncogene, thrombopoietin receptor [KO:K05082]
100009046  PRLR; prolactin receptor [KO:K05081]
100008806  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
100343006  PDGFRA; platelet derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
100342872  PDGFRB; platelet derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
100352594  JAK1; Janus kinase 1 [KO:K11217] [EC:2.7.10.2]
100358134  JAK2; Janus kinase 2 [KO:K04447] [EC:2.7.10.2]
100344622  TYK2; tyrosine kinase 2 [KO:K11219] [EC:2.7.10.2]
100343893  STAT1; signal transducer and activator of transcription 1 [KO:K11220]
100344467  STAT2; signal transducer and activator of transcription 2 [KO:K11221]
100348778  STAT3; signal transducer and activator of transcription 3 [KO:K04692]
100344146  STAT4; signal transducer and activator of transcription 4 [KO:K11222]
100348518  signal transducer and activator of transcription 5A [KO:K11223]
100348267  STAT5B; signal transducer and activator of transcription 5B [KO:K11224]
100344264  STAT6; signal transducer and activator of transcription 6 [KO:K11225]
100341861  CISH; cytokine inducible SH2 containing protein [KO:K04701]
100339386  SOCS1; suppressor of cytokine signaling 1 [KO:K04694]
100354019  SOCS2; suppressor of cytokine signaling 2 [KO:K04695]
100357417  SOCS4; suppressor of cytokine signaling 4 [KO:K04697]
100353407  SOCS5; suppressor of cytokine signaling 5 [KO:K04698]
100344911  SOCS6; suppressor of cytokine signaling 6 [KO:K04699]
100351533  SOCS7; suppressor of cytokine signaling 7 [KO:K04699]
103349397  BCL2; BCL2, apoptosis regulator [KO:K02161]
100359222  MCL1; BCL2 family apoptosis regulator [KO:K02539]
100008875  BCL2L1; BCL2 like 1 [KO:K04570]
100342639  PIM1; Pim-1 proto-oncogene, serine/threonine kinase [KO:K04702] [EC:2.7.11.1]
100327265  MYC; v-myc avian myelocytomatosis viral oncogene homolog [KO:K04377]
100009036  CCND2; cyclin D2 [KO:K10151]
100009038  CCND3; cyclin D3 [KO:K10152]
100348489  CDKN1A; cyclin dependent kinase inhibitor 1A [KO:K06625]
100354428  AOX4; aldehyde oxidase 4 [KO:K00157] [EC:1.2.3.1]
100345417  AOX2; aldehyde oxidase 2 [KO:K00157] [EC:1.2.3.1]
100345675  AOX3; aldehyde oxidase 3 [KO:K00157] [EC:1.2.3.1]
100008601  AOX1; aldehyde oxidase 1 [KO:K00157] [EC:1.2.3.1]
100352532  GFAP; glial fibrillary acidic protein [KO:K05640]
100346128  STAM; signal transducing adaptor molecule [KO:K04705]
100351322  STAM2; signal transducing adaptor molecule 2 [KO:K04705]
100338151  PTPN2; protein tyrosine phosphatase, non-receptor type 2 [KO:K18026] [EC:3.1.3.48]
100348648  PTPN6; protein tyrosine phosphatase, non-receptor type 6 [KO:K05697] [EC:3.1.3.48]
100344432  IRF9; interferon regulatory factor 9 [KO:K04693]
100354135  EP300; E1A binding protein p300 [KO:K04498] [EC:2.3.1.48]
100340619  CREBBP; CREB binding protein [KO:K04498] [EC:2.3.1.48]
100339509  PIAS1; protein inhibitor of activated STAT 1 [KO:K04706] [EC:2.3.2.-]
100357839  PIAS2; protein inhibitor of activated STAT 2 [KO:K16063] [EC:2.3.2.-]
100341019  PIAS3; protein inhibitor of activated STAT 3 [KO:K16064] [EC:2.3.2.-]
100357263  FHL1; four and a half LIM domains 1 [KO:K14365]
100339517  PTPN11; protein tyrosine phosphatase, non-receptor type 11 [KO:K07293] [EC:3.1.3.48]
100342500  GRB2; growth factor receptor bound protein 2 [KO:K04364]
100356615  SOS1; SOS Ras/Rac guanine nucleotide exchange factor 1 [KO:K03099]
100346391  SOS2; SOS Ras/Rho guanine nucleotide exchange factor 2 [KO:K03099]
100347407  RAF1; Raf-1 proto-oncogene, serine/threonine kinase [KO:K04366] [EC:2.7.11.1]
100348663  PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta [KO:K00922] [EC:2.7.1.153]
100345181  PIK3CB; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta [KO:K00922] [EC:2.7.1.153]
100337822  PIK3CA; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha [KO:K00922] [EC:2.7.1.153]
100357841  PIK3R1; phosphoinositide-3-kinase regulatory subunit 1 [KO:K02649]
100345250  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
100342852  AKT2; AKT serine/threonine kinase 2 [KO:K04456] [EC:2.7.11.1]
100353706  AKT3; AKT serine/threonine kinase 3 [KO:K04456] [EC:2.7.11.1]
100356164  MTOR; mechanistic target of rapamycin [KO:K07203] [EC:2.7.11.1]
Reference
  Authors
Harrison DA
  Title
The Jak/STAT pathway.
  Journal
Cold Spring Harb Perspect Biol 4:a011205 (2012)
DOI:10.1101/cshperspect.a011205
Reference
  Authors
Kiu H, Nicholson SE
  Title
Biology and significance of the JAK/STAT signalling pathways.
  Journal
Growth Factors 30:88-106 (2012)
DOI:10.3109/08977194.2012.660936
Reference
  Authors
Hervas-Stubbs S, Perez-Gracia JL, Rouzaut A, Sanmamed MF, Le Bon A, Melero I
  Title
Direct effects of type I interferons on cells of the immune system.
  Journal
Clin Cancer Res 17:2619-27 (2011)
DOI:10.1158/1078-0432.CCR-10-1114
Reference
  Authors
Fish EN, Platanias LC
  Title
Interferon receptor signaling in malignancy: a network of cellular pathways defining biological outcomes.
  Journal
Mol Cancer Res 12:1691-703 (2014)
DOI:10.1158/1541-7786.MCR-14-0450
Reference
  Authors
Ivanenkov YA, Balakin KV, Lavrovsky Y
  Title
Small molecule inhibitors of NF-kB and JAK/STAT signal transduction pathways as promising anti-inflammatory therapeutics.
  Journal
Mini Rev Med Chem 11:55-78 (2011)
DOI:10.2174/138955711793564079
Reference
  Authors
O'Shea JJ, Schwartz DM, Villarino AV, Gadina M, McInnes IB, Laurence A
  Title
The JAK-STAT pathway: impact on human disease and therapeutic intervention.
  Journal
Annu Rev Med 66:311-28 (2015)
DOI:10.1146/annurev-med-051113-024537
Reference
  Authors
Zoranovic T, Grmai L, Bach EA
  Title
Regulation of proliferation, cell competition, and cellular growth by the Drosophila JAK-STAT pathway.
  Journal
JAKSTAT 2:e25408 (2013)
DOI:10.4161/jkst.25408
Reference
  Authors
Ungureanu D, Silvennoinen O
  Title
SLIM trims STATs: ubiquitin E3 ligases provide insights for specificity in the regulation of cytokine signaling.
  Journal
Sci STKE 2005:pe49 (2005)
DOI:10.1126/stke.3042005pe49
Reference
  Authors
Richard AJ, Stephens JM
  Title
The role of JAK-STAT signaling in adipose tissue function.
  Journal
Biochim Biophys Acta 1842:431-9 (2014)
DOI:10.1016/j.bbadis.2013.05.030
Reference
  Authors
Sun Y, Lehmbecker A, Kalkuhl A, Deschl U, Sun W, Rohn K, Tzvetanova ID, Nave KA, Baumgartner W, Ulrich R
  Title
STAT3 represents a molecular switch possibly inducing astroglial instead of oligodendroglial differentiation of oligodendroglial progenitor cells in Theiler's murine encephalomyelitis.
  Journal
Neuropathol Appl Neurobiol 41:347-70 (2015)
DOI:10.1111/nan.12133
Reference
  Authors
Hirano T, Ishihara K, Hibi M
  Title
Roles of STAT3 in mediating the cell growth, differentiation and survival signals relayed through the IL-6 family of cytokine receptors.
  Journal
Oncogene 19:2548-56 (2000)
DOI:10.1038/sj.onc.1203551
Reference
  Authors
Rane SG, Reddy EP
  Title
Janus kinases: components of multiple signaling pathways.
  Journal
Oncogene 19:5662-79 (2000)
DOI:10.1038/sj.onc.1203925
Reference
PMID:8682149
  Authors
Heim MH
  Title
The Jak-STAT pathway: specific signal transduction from the cell membrane to the nucleus.
  Journal
Eur J Clin Invest 26:1-12 (1996)
DOI:10.1046/j.1365-2362.1996.103248.x
Related
pathway
ocu04010  MAPK signaling pathway
ocu04060  Cytokine-cytokine receptor interaction
ocu04110  Cell cycle
ocu04120  Ubiquitin mediated proteolysis
ocu04151  PI3K-Akt signaling pathway
ocu04210  Apoptosis
KO pathway
ko04630   
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