KEGG   PATHWAY: aamp05162
Entry
aamp05162                   Pathway                                
Name
Measles - Arvicola amphibius (Eurasian water vole)
Description
Measles virus (MV) is highly contagious virus that leads infant death worldwide. Humans are the unique natural reservoir for this virus. MV infection is characterized by virus-induced immune suppression that can lead to increased susceptibility to secondary bacterial and viral infections. The P, V and C proteins act as virulence factors to suppress innate immune response in host by inhibiting signaling for both type I IFN induction and JAK/STAT-mediated interferon-stimulated gene (ISG) induction. Moreover,  H protein expressed on viral particles and binding to SLAM or CD46,  as well as N protein liberated from infected cells and interacting with Fc-gamma R, causes an inhibition of IL-12 synthesis in dendritic cells. IL-12 is a key cytokine inducing cellular immune responses to protect host from the harm caused by pathogenic infections.
Class
Human Diseases; Infectious disease: viral
Pathway map
aamp05162  Measles
aamp05162

Organism
Arvicola amphibius (Eurasian water vole) [GN:aamp]
Gene
119821696  membrane cofactor protein-like [KO:K04007]
119827211  Cd46; membrane cofactor protein [KO:K04007]
119804653  Msn; moesin [KO:K05763]
119828019  Slamf1; signaling lymphocytic activation molecule isoform X1 [KO:K06536]
119824403  LOW QUALITY PROTEIN: CD209 antigen-like protein D [KO:K06563]
119824404  CD209 antigen-like protein E [KO:K06563]
119824824  CD209 antigen-like protein B [KO:K06563]
119824887  CD209 antigen-like protein C isoform X1 [KO:K06563]
119825073  CD209 antigen-like protein E [KO:K06563]
119825134  CD209 antigen-like protein A [KO:K06563]
119825143  CD209 antigen-like protein E [KO:K06563]
119825215  CD209 antigen-like protein C [KO:K06563]
119825522  CD209 antigen-like protein E [KO:K06563]
119824405  CD209 antigen-like protein C [KO:K06563]
119826628  Ddx58; antiviral innate immune response receptor RIG-I [KO:K12646] [EC:5.6.2.6]
119819080  Ifih1; interferon-induced helicase C domain-containing protein 1 [KO:K12647] [EC:5.6.2.6]
119814914  Mavs; mitochondrial antiviral-signaling protein [KO:K12648]
119818887  Traf3; TNF receptor-associated factor 3 isoform X1 [KO:K03174]
119827931  Ikbke; inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X1 [KO:K07211] [EC:2.7.11.10]
119803361  Tbk1; serine/threonine-protein kinase TBK1 [KO:K05410] [EC:2.7.11.10]
119802528  Irf3; interferon regulatory factor 3 isoform X1 [KO:K05411]
119816335  Chuk; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
119812324  Ikbkb; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
119804668  Ikbkg; NF-kappa-B essential modulator isoform X1 [KO:K07210]
119820618  Nfkbib; NF-kappa-B inhibitor beta [KO:K02581]
119818958  Nfkbia; NF-kappa-B inhibitor alpha [KO:K04734]
119801102  Nfkb1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
119803437  Rela; transcription factor p65 isoform X1 [KO:K04735]
119804959  Tlr7; toll-like receptor 7 [KO:K05404]
119810686  toll-like receptor 9 isoform X1 [KO:K10161]
119809015  Myd88; myeloid differentiation primary response protein MyD88 [KO:K04729]
119805097  Irak1; interleukin-1 receptor-associated kinase 1 isoform X1 [KO:K04730] [EC:2.7.11.1]
119822715  Irak4; interleukin-1 receptor-associated kinase 4 [KO:K04733] [EC:2.7.11.1]
119821228  Irf7; interferon regulatory factor 7 isoform X1 [KO:K09447]
121677052  interferon alpha-12-like [KO:K05414]
121677053  interferon alpha-12-like [KO:K05414]
121677054  interferon alpha-9-like [KO:K05414]
119817047  interferon alpha-12-like [KO:K05414]
119817048  LOW QUALITY PROTEIN: interferon alpha-12-like [KO:K05414]
119817051  interferon alpha-12-like [KO:K05414]
119817054  interferon alpha-12-like [KO:K05414]
119817055  interferon alpha-12-like [KO:K05414]
119817056  interferon alpha-12-like [KO:K05414]
119817057  interferon alpha-12-like [KO:K05414]
119817059  interferon alpha-12-like [KO:K05414]
119817275  interferon alpha-12-like [KO:K05414]
119805874  interferon alpha-12-like [KO:K05414]
119805875  interferon alpha-12-like [KO:K05414]
119805877  interferon alpha-12-like [KO:K05414]
119805879  interferon alpha-12-like [KO:K05414]
119805881  interferon alpha-12-like [KO:K05414]
119805882  interferon alpha-12-like [KO:K05414]
119805887  interferon alpha-12-like [KO:K05414]
119805888  interferon alpha-12-like [KO:K05414]
119805889  interferon alpha-12-like [KO:K05414]
119805892  interferon alpha-9-like [KO:K05414]
119816165  Ifnb1; LOW QUALITY PROTEIN: interferon beta [KO:K05415]
119817276  interferon beta-like [KO:K05415]
119826466  Tlr2; toll-like receptor 2 [KO:K10159]
119818005  Tlr4; toll-like receptor 4 [KO:K10160]
119814858  Traf6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
119802199  Csnk2a2; casein kinase II subunit alpha' [KO:K03097] [EC:2.7.11.1]
119814096  Csnk2a1; LOW QUALITY PROTEIN: casein kinase II subunit alpha [KO:K03097] [EC:2.7.11.1]
119822509  Csnk2b; casein kinase II subunit beta [KO:K03115]
119820781  Tnfaip3; tumor necrosis factor alpha-induced protein 3 isoform X1 [KO:K11859] [EC:3.4.19.12]
119826355  Map3k7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
119820349  Tab2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 [KO:K04404]
119811270  Mapk9; LOW QUALITY PROTEIN: mitogen-activated protein kinase 9 [KO:K04440] [EC:2.7.11.24]
119813574  Mapk10; mitogen-activated protein kinase 10 [KO:K04440] [EC:2.7.11.24]
119827427  Mapk8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
119816694  Jun; transcription factor AP-1 [KO:K04448]
119819161  Fos; proto-oncogene c-Fos [KO:K04379]
119813991  Il1a; interleukin-1 alpha [KO:K04383]
119814887  Il1b; interleukin-1 beta [KO:K04519]
119808459  Il6; interleukin-6 [KO:K05405]
119826750  Il12a; interleukin-12 subunit alpha [KO:K05406]
119811033  Il12b; interleukin-12 subunit beta [KO:K05425]
119825470  Ifnar1; interferon alpha/beta receptor 1 [KO:K05130]
119824686  Ifnar2; interferon alpha/beta receptor 2 [KO:K05131]
119811783  Rack1; receptor of activated protein C kinase 1 [KO:K14753]
119816123  Jak1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
119809989  Tyk2; non-receptor tyrosine-protein kinase TYK2 [KO:K11219] [EC:2.7.10.2]
119803912  Stat1; signal transducer and activator of transcription 1-alpha/beta [KO:K11220]
119803231  Stat2; signal transducer and activator of transcription 2 [KO:K11221]
119799968  Irf9; interferon regulatory factor 9 isoform X1 [KO:K04693]
119824522  Oas3; 2'-5'-oligoadenylate synthase 3 [KO:K14216] [EC:2.7.7.84]
119824530  Oas1; 2'-5'-oligoadenylate synthase 1 [KO:K14216] [EC:2.7.7.84]
119824811  Oas2; 2'-5'-oligoadenylate synthase 2 [KO:K14216] [EC:2.7.7.84]
119824866  2'-5'-oligoadenylate synthase 1A-like [KO:K14216] [EC:2.7.7.84]
119800877  Adar; double-stranded RNA-specific adenosine deaminase isoform X1 [KO:K12968] [EC:3.5.4.37]
119824623  Mx1; interferon-induced GTP-binding protein Mx1 [KO:K14754]
119825258  interferon-induced GTP-binding protein Mx1-like isoform X1 [KO:K14754]
119824668  Eif2ak1; eukaryotic translation initiation factor 2-alpha kinase 1 [KO:K16194] [EC:2.7.11.1]
119808127  Eif2ak2; interferon-induced, double-stranded RNA-activated protein kinase [KO:K16195] [EC:2.7.11.1]
119808167  Eif2ak3; eukaryotic translation initiation factor 2-alpha kinase 3 [KO:K08860] [EC:2.7.11.1]
119814070  Eif2ak4; eIF-2-alpha kinase GCN2 isoform X1 [KO:K16196] [EC:2.7.11.1]
119805220  Rab9a; ras-related protein Rab-9A isoform X1 [KO:K07899]
119805515  Rab9b; ras-related protein Rab-9B [KO:K07900]
119808171  heat shock cognate 71 kDa protein-like [KO:K03283]
119827066  Hspa6; LOW QUALITY PROTEIN: heat shock 70 kDa protein 6 [KO:K03283]
119809148  Hspa8; heat shock cognate 71 kDa protein [KO:K03283]
119822472  heat shock 70 kDa protein 1A [KO:K03283]
119822473  heat shock 70 kDa protein 1-like [KO:K03283]
119822478  heat shock 70 kDa protein 1A [KO:K03283]
119816023  heat shock cognate 71 kDa protein-like [KO:K03283]
119822758  heat shock cognate 71 kDa protein-like [KO:K03283]
119826334  heat shock cognate 71 kDa protein-like [KO:K03283]
119823497  Eif3h; eukaryotic translation initiation factor 3 subunit H [KO:K03247]
119818610  Eif2s1; eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
119812740  Rchy1; RING finger and CHY zinc finger domain-containing protein 1 isoform X1 [KO:K10144] [EC:2.3.2.27]
119818608  cellular tumor antigen p53-like [KO:K04451]
119813419  Tp53; cellular tumor antigen p53 [KO:K04451]
119816622  Tp73; tumor protein p73 [KO:K10148]
119820729  Bbc3; bcl-2-binding component 3 [KO:K10132]
119827881  Faslg; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
119804936  Fas; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
119801899  Tradd; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
119802203  Fadd; FAS-associated death domain protein [KO:K02373]
119803862  Casp8; caspase-8 [KO:K04398] [EC:3.4.22.61]
119806482  Bid; BH3-interacting domain death agonist [KO:K04726]
119802627  Bax; apoptosis regulator BAX isoform X1 [KO:K02159]
119823918  Bak1; bcl-2 homologous antagonist/killer [KO:K14021]
119827718  Bcl2; apoptosis regulator Bcl-2 [KO:K02161]
119815691  Bcl2l1; bcl-2-like protein 1 [KO:K04570]
119820525  Bad; bcl2-associated agonist of cell death isoform X1 [KO:K02158]
119807948  cytochrome c, somatic-like [KO:K08738]
119827640  cytochrome c, somatic-like [KO:K08738]
119812378  cytochrome c, somatic [KO:K08738]
119812503  cytochrome c, somatic-like [KO:K08738]
119819008  cytochrome c, testis-specific [KO:K08738]
119807481  cytochrome c, somatic [KO:K08738]
119803346  Apaf1; apoptotic protease-activating factor 1 [KO:K02084]
119817619  Casp9; caspase-9 [KO:K04399] [EC:3.4.22.62]
119812861  Casp3; caspase-3 [KO:K02187] [EC:3.4.22.56]
119807071  Cdkn1b; cyclin-dependent kinase inhibitor 1B [KO:K06624]
119827335  Ccnd1; G1/S-specific cyclin-D1 [KO:K04503]
119808297  Ccnd2; G1/S-specific cyclin-D2 [KO:K10151]
119823258  Ccnd3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
119820977  Ccne1; G1/S-specific cyclin-E1 [KO:K06626]
119804174  G1/S-specific cyclin-E2-like [KO:K06626]
119826163  Ccne2; G1/S-specific cyclin-E2 isoform X1 [KO:K06626]
119803317  Cdk4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
119807882  Cdk6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
119803337  Cdk2; cyclin-dependent kinase 2 isoform X1 [KO:K02206] [EC:2.7.11.22]
119809864  Cd3d; T-cell surface glycoprotein CD3 delta chain isoform X1 [KO:K06450]
119810074  Cd3e; T-cell surface glycoprotein CD3 epsilon chain [KO:K06451]
119809863  Cd3g; T-cell surface glycoprotein CD3 gamma chain [KO:K06452]
119821216  Cd28; T-cell-specific surface glycoprotein CD28 isoform X1 [KO:K06470]
119825919  Il2; interleukin-2 [KO:K05429]
119817084  Il2ra; interleukin-2 receptor subunit alpha [KO:K05068]
119823009  Il2rb; interleukin-2 receptor subunit beta [KO:K05069]
119804964  Il2rg; cytokine receptor common subunit gamma [KO:K05070]
119808979  Pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
119817743  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
119812102  Pik3r2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
119816315  Pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
119810503  Pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
119826317  Pik3ca; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
119824571  Cblb; E3 ubiquitin-protein ligase CBL-B isoform X1 [KO:K22517] [EC:2.3.2.27]
119818643  Akt1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
119820487  Akt2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
119827246  Akt3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
119824224  Gsk3b; LOW QUALITY PROTEIN: glycogen synthase kinase-3 beta [KO:K03083] [EC:2.7.11.26]
119811901  Jak3; tyrosine-protein kinase JAK3 isoform X1 [KO:K11218] [EC:2.7.10.2]
119811206  Stat3; signal transducer and activator of transcription 3 isoform X1 [KO:K04692]
119812127  signal transducer and activator of transcription 5A [KO:K11223]
119811038  signal transducer and activator of transcription 5B isoform X1 [KO:K11224]
119827205  Fcgr2b; low affinity immunoglobulin gamma Fc region receptor II-b isoform X1 [KO:K12560]
Compound
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:19203113
  Authors
Schneider-Schaulies S, Schneider-Schaulies J
  Title
Measles virus-induced immunosuppression.
  Journal
Curr Top Microbiol Immunol 330:243-69 (2009)
DOI:10.1007/978-3-540-70617-5_12
Reference
PMID:19203114
  Authors
Hahm B
  Title
Hostile communication of measles virus with host innate immunity and dendritic cells.
  Journal
Curr Top Microbiol Immunol 330:271-87 (2009)
DOI:10.1007/978-3-540-70617-5_13
Reference
PMID:19198566
  Authors
Gerlier D, Valentin H
  Title
Measles virus interaction with host cells and impact on innate immunity.
  Journal
Curr Top Microbiol Immunol 329:163-91 (2009)
DOI:10.1007/978-3-540-70523-9_8
Reference
PMID:16690907
  Authors
Schneider-Schaulies S, Dittmer U
  Title
Silencing T cells or T-cell silencing: concepts in virus-induced immunosuppression.
  Journal
J Gen Virol 87:1423-38 (2006)
DOI:10.1099/vir.0.81713-0
Reference
PMID:22049305
  Authors
Avota E, Gassert E, Schneider-Schaulies S
  Title
Cytoskeletal dynamics: concepts in measles virus replication and immunomodulation.
  Journal
Viruses 3:102-17 (2011)
DOI:10.3390/v3020102
Reference
PMID:27854326
  Authors
Jiang Y, Qin Y, Chen M
  Title
Host-Pathogen Interactions in Measles Virus Replication and Anti-Viral Immunity.
  Journal
Viruses 8:E308 (2016)
DOI:10.3390/v8110308
Reference
PMID:18922877
  Authors
Pfaller CK, Conzelmann KK
  Title
Measles virus V protein is a decoy substrate for IkappaB kinase alpha and prevents Toll-like receptor 7/9-mediated interferon induction.
  Journal
J Virol 82:12365-73 (2008)
DOI:10.1128/JVI.01321-08
Reference
PMID:17720800
  Authors
Yokota S, Okabayashi T, Yokosawa N, Fujii N
  Title
Measles virus P protein suppresses Toll-like receptor signal through up-regulation of ubiquitin-modifying enzyme A20.
  Journal
FASEB J 22:74-83 (2008)
DOI:10.1096/fj.07-8976com
Reference
PMID:23146309
  Authors
Delpeut S, Noyce RS, Siu RW, Richardson CD
  Title
Host factors and measles virus replication.
  Journal
Curr Opin Virol 2:773-83 (2012)
DOI:10.1016/j.coviro.2012.10.008
Reference
PMID:26878224
  Authors
Shah M, Anwar MA, Kim JH, Choi S
  Title
Advances in Antiviral Therapies Targeting Toll-like Receptors.
  Journal
Expert Opin Investig Drugs 25:437-53 (2016)
DOI:10.1517/13543784.2016.1154040
Reference
PMID:12620806
  Authors
Yokota S, Saito H, Kubota T, Yokosawa N, Amano K, Fujii N
  Title
Measles virus suppresses interferon-alpha signaling pathway: suppression of Jak1 phosphorylation and association of viral accessory proteins, C and V, with interferon-alpha receptor complex.
  Journal
Virology 306:135-46 (2003)
DOI:10.1016/S0042-6822(02)00026-0
Reference
PMID:12804771
  Authors
Takeuchi K, Kadota SI, Takeda M, Miyajima N, Nagata K
  Title
Measles virus V protein blocks interferon (IFN)-alpha/beta but not IFN-gamma signaling by inhibiting STAT1 and STAT2 phosphorylation.
  Journal
FEBS Lett 545:177-82 (2003)
DOI:10.1016/S0014-5793(03)00528-3
Reference
PMID:12805463
  Authors
Palosaari H, Parisien JP, Rodriguez JJ, Ulane CM, Horvath CM
  Title
STAT protein interference and suppression of cytokine signal transduction by measles virus V protein.
  Journal
J Virol 77:7635-44 (2003)
DOI:10.1128/JVI.77.13.7635-7644.2003
Reference
PMID:14585342
  Authors
Shaffer JA, Bellini WJ, Rota PA
  Title
The C protein of measles virus inhibits the type I interferon response.
  Journal
Virology 315:389-97 (2003)
DOI:10.1016/S0042-6822(03)00537-3
Reference
PMID:16971451
  Authors
Carsillo T, Traylor Z, Choi C, Niewiesk S, Oglesbee M
  Title
hsp72, a host determinant of measles virus neurovirulence.
  Journal
J Virol 80:11031-9 (2006)
DOI:10.1128/JVI.01438-06
Reference
PMID:15914229
  Authors
Zhang X, Bourhis JM, Longhi S, Carsillo T, Buccellato M, Morin B, Canard B, Oglesbee M
  Title
Hsp72 recognizes a P binding motif in the measles virus N protein C-terminus.
  Journal
Virology 337:162-74 (2005)
DOI:10.1016/j.virol.2005.03.035
Reference
PMID:29712906
  Authors
Ke Z, Strauss JD, Hampton CM, Brindley MA, Dillard RS, Leon F, Lamb KM, Plemper RK, Wright ER
  Title
Promotion of virus assembly and organization by the measles virus matrix protein.
  Journal
Nat Commun 9:1736 (2018)
DOI:10.1038/s41467-018-04058-2
Reference
PMID:24155404
  Authors
Pfaller CK, Radeke MJ, Cattaneo R, Samuel CE
  Title
Measles virus C protein impairs production of defective copyback double-stranded viral RNA and activation of protein kinase R.
  Journal
J Virol 88:456-68 (2014)
DOI:10.1128/JVI.02572-13
Reference
PMID:17686838
  Authors
Sato H, Masuda M, Kanai M, Tsukiyama-Kohara K, Yoneda M, Kai C
  Title
Measles virus N protein inhibits host translation by binding to eIF3-p40.
  Journal
J Virol 81:11569-76 (2007)
DOI:10.1128/JVI.00570-07
Reference
PMID:19895323
  Authors
Sion-Vardy N, Lasarov I, Delgado B, Gopas J, Benharroch D, Ariad S
  Title
Measles virus: evidence for association with lung cancer.
  Journal
Exp Lung Res 35:701-12 (2009)
DOI:10.3109/01902140902853176
Reference
PMID:16140759
  Authors
Chen M, Cortay JC, Logan IR, Sapountzi V, Robson CN, Gerlier D
  Title
Inhibition of ubiquitination and stabilization of human ubiquitin E3 ligase PIRH2 by measles virus phosphoprotein.
  Journal
J Virol 79:11824-36 (2005)
DOI:10.1128/JVI.79.18.11824-11836.2005
Reference
PMID:16699046
  Authors
Cruz CD, Palosaari H, Parisien JP, Devaux P, Cattaneo R, Ouchi T, Horvath CM
  Title
Measles virus V protein inhibits p53 family member p73.
  Journal
J Virol 80:5644-50 (2006)
DOI:10.1128/JVI.02400-05
Reference
PMID:10756053
  Authors
Servet-Delprat C, Vidalain PO, Azocar O, Le Deist F, Fischer A, Rabourdin-Combe C
  Title
Consequences of Fas-mediated human dendritic cell apoptosis induced by measles virus.
  Journal
J Virol 74:4387-93 (2000)
DOI:10.1128/JVI.74.9.4387-4393.2000
Reference
PMID:20601611
  Authors
Kushwah R, Hu J
  Title
Dendritic cell apoptosis: regulation of tolerance versus immunity.
  Journal
J Immunol 185:795-802 (2010)
DOI:10.4049/jimmunol.1000325
Reference
PMID:10590149
  Authors
Vidalain PO, Azocar O, Lamouille B, Astier A, Rabourdin-Combe C, Servet-Delprat C
  Title
Measles virus induces functional TRAIL production by human dendritic cells.
  Journal
J Virol 74:556-9 (2000)
DOI:10.1128/JVI.74.1.556-559.2000
Reference
PMID:11846228
  Authors
Vidalain PO, Azocar O, Rabourdin-Combe C, Servet-Delprat C
  Title
Measle virus-infected dendritic cells develop immunosuppressive and cytotoxic activities.
  Journal
Immunobiology 204:629-38 (2001)
DOI:10.1078/0171-2985-00102
Reference
PMID:10423127
  Authors
Engelking O, Fedorov LM, Lilischkis R, ter Meulen V, Schneider-Schaulies S
  Title
Measles virus-induced immunosuppression in vitro is associated with deregulation of G1 cell cycle control proteins.
  Journal
J Gen Virol 80 ( Pt 7):1599-608 (1999)
DOI:10.1099/0022-1317-80-7-1599
Reference
PMID:30510918
  Authors
Fan Y, Sanyal S, Bruzzone R
  Title
Breaking Bad: How Viruses Subvert the Cell Cycle.
  Journal
Front Cell Infect Microbiol 8:396 (2018)
DOI:10.3389/fcimb.2018.00396
Reference
PMID:20636817
  Authors
Griffin DE
  Title
Measles virus-induced suppression of immune responses.
  Journal
Immunol Rev 236:176-89 (2010)
DOI:10.1111/j.1600-065X.2010.00925.x
Reference
PMID:11385511
  Authors
Avota E, Avots A, Niewiesk S, Kane LP, Bommhardt U, ter Meulen V, Schneider-Schaulies S
  Title
Disruption of Akt kinase activation is important for immunosuppression induced by measles virus.
  Journal
Nat Med 7:725-31 (2001)
DOI:10.1038/89106
Reference
PMID:15308747
  Authors
Avota E, Muller N, Klett M, Schneider-Schaulies S
  Title
Measles virus interacts with and alters signal transduction in T-cell lipid rafts.
  Journal
J Virol 78:9552-9 (2004)
DOI:10.1128/JVI.78.17.9552-9559.2004
Reference
PMID:16963735
  Authors
Yanagi Y, Takeda M, Ohno S
  Title
Measles virus: cellular receptors, tropism and pathogenesis.
  Journal
J Gen Virol 87:2767-79 (2006)
DOI:10.1099/vir.0.82221-0
Reference
PMID:16237742
  Authors
Kerdiles YM, Sellin CI, Druelle J, Horvat B
  Title
Immunosuppression caused by measles virus: role of viral proteins.
  Journal
Rev Med Virol 16:49-63 (2006)
DOI:10.1002/rmv.486
Related
pathway
aamp04110  Cell cycle
aamp04115  p53 signaling pathway
aamp04120  Ubiquitin mediated proteolysis
aamp04210  Apoptosis
aamp04620  Toll-like receptor signaling pathway
aamp04622  RIG-I-like receptor signaling pathway
aamp04630  JAK-STAT signaling pathway
aamp04658  Th1 and Th2 cell differentiation
aamp04660  T cell receptor signaling pathway
KO pathway
ko05162   
LinkDB

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