KEGG   PATHWAY: ajm05169
Entry
ajm05169                    Pathway                                
Name
Epstein-Barr virus infection - Artibeus jamaicensis (Jamaican fruit-eating bat)
Description
Epstein-Barr virus (EBV) is a gamma-herpes virus that widely infects human populations predominantly at an early age but remains mostly asymptomatic. EBV has been linked to a wide spectrum of human malignancies, including nasopharyngeal carcinoma and other hematologic cancers, like Hodgkin's lymphoma, Burkitt's lymphoma (BL), B-cell immunoblastic lymphoma in HIV patients, and posttransplant-associated lymphoproliferative diseases.  EBV has the unique ability to establish life-long latent infection in primary human B lymphocytes. During latent infection, EBV expresses a small subset of genes, including 6 nuclear antigens (EBNA-1, -2, -3A, -3B, -3C, and -LP), 3 latent membrane proteins (LMP-1, -2A, and -2B), 2 small noncoding RNAs (EBER-1 and 2). On the basis of these latent gene expression, three different latency patterns associated with the types of cancers are recognized.
Class
Human Diseases; Infectious disease: viral
Pathway map
ajm05169  Epstein-Barr virus infection
ajm05169

Organism
Artibeus jamaicensis (Jamaican fruit-eating bat) [GN:ajm]
Gene
119056821  CR2; LOW QUALITY PROTEIN: complement receptor type 2 [KO:K04012]
119045362  CD19; B-lymphocyte antigen CD19 isoform X1 [KO:K06465]
119038537  HLA class II histocompatibility antigen, DQ beta 2 chain-like [KO:K06752]
119040562  SLA class II histocompatibility antigen, DQ haplotype D alpha chain-like [KO:K06752]
119040793  SLA class II histocompatibility antigen, DQ haplotype D alpha chain-like [KO:K06752]
119040794  SLA class II histocompatibility antigen, DQ haplotype D alpha chain-like [KO:K06752]
119052984  HLA class II histocompatibility antigen, DM beta chain [KO:K06752]
119052987  HLA class II histocompatibility antigen, DM alpha chain isoform X1 [KO:K06752]
119060698  LOW QUALITY PROTEIN: HLA class II histocompatibility antigen, DP alpha 1 chain-like [KO:K06752]
119061214  H-2 class II histocompatibility antigen, A-D beta chain-like [KO:K06752]
119062087  DLA class II histocompatibility antigen, DR-1 beta chain-like [KO:K06752]
119055692  DLA class II histocompatibility antigen, DR-1 beta chain-like [KO:K06752]
119055693  H-2 class II histocompatibility antigen, E-S beta chain-like [KO:K06752]
119055694  HLA class II histocompatibility antigen, DR alpha chain-like [KO:K06752]
119048626  rano class II histocompatibility antigen, A beta chain-like [KO:K06752]
119056744  DLA class II histocompatibility antigen, DR-1 beta chain-like [KO:K06752]
119056745  HLA class II histocompatibility antigen, DR alpha chain-like [KO:K06752]
119049925  HLA class II histocompatibility antigen, DR alpha chain-like [KO:K06752]
119057940  SLA class II histocompatibility antigen, DQ haplotype D alpha chain-like [KO:K06752]
119065905  TLR2; toll-like receptor 2 isoform X1 [KO:K10159]
119051446  MYD88; myeloid differentiation primary response protein MyD88 isoform X1 [KO:K04729]
119061695  IRAK4; interleukin-1 receptor-associated kinase 4 isoform X1 [KO:K04733] [EC:2.7.11.1]
119053563  IRAK1; interleukin-1 receptor-associated kinase 1 [KO:K04730] [EC:2.7.11.1]
119036455  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
119060232  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform X1 [KO:K04403]
119057909  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1 [KO:K04404]
119041421  mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
119064546  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
119047140  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
119053789  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
119062929  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
119057921  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
119050282  RELA; transcription factor p65 [KO:K04735]
119053704  TNF; tumor necrosis factor isoform X1 [KO:K03156]
119042560  IL6; interleukin-6 isoform X1 [KO:K05405]
119060014  DDX58; antiviral innate immune response receptor RIG-I [KO:K12646] [EC:5.6.2.6]
119051154  MAVS; mitochondrial antiviral-signaling protein [KO:K12648]
119037870  TRAF3; TNF receptor-associated factor 3 isoform X1 [KO:K03174]
119045546  TBK1; serine/threonine-protein kinase TBK1 [KO:K05410] [EC:2.7.11.10]
119056820  IKBKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X1 [KO:K07211] [EC:2.7.11.10]
119062180  IRF7; interferon regulatory factor 7 isoform X1 [KO:K09447]
119045996  IRF3; interferon regulatory factor 3 isoform X1 [KO:K05411]
119058844  interferon alpha-4-like [KO:K05414]
119045866  interferon alpha-7 [KO:K05414]
119045867  interferon alpha-4 [KO:K05414]
119056303  interferon alpha-4-like [KO:K05414]
119049818  interferon alpha-4-like [KO:K05414]
119055662  IFNB1; interferon beta [KO:K05415]
119035720  IFNAR1; interferon alpha/beta receptor 1 [KO:K05130]
119035719  IFNAR2; interferon alpha/beta receptor 2 isoform X1 [KO:K05131]
119042494  JAK1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
119055683  non-receptor tyrosine-protein kinase TYK2-like [KO:K11219] [EC:2.7.10.2]
119062093  STAT1; signal transducer and activator of transcription 1-alpha/beta isoform X1 [KO:K11220]
119040310  STAT2; signal transducer and activator of transcription 2 [KO:K11221]
119037294  IRF9; interferon regulatory factor 9 [KO:K04693]
119063844  EIF2AK2; interferon-induced, double-stranded RNA-activated protein kinase isoform X1 [KO:K16195] [EC:2.7.11.1]
119040446  OAS3; 2'-5'-oligoadenylate synthase 3 isoform X1 [KO:K14216] [EC:2.7.7.84]
119040447  OAS1; 2'-5'-oligoadenylate synthase 1 [KO:K14216] [EC:2.7.7.84]
119040463  OAS2; LOW QUALITY PROTEIN: 2'-5'-oligoadenylate synthase 2 [KO:K14216] [EC:2.7.7.84]
119056133  2'-5'-oligoadenylate synthase 1-like [KO:K14216] [EC:2.7.7.84]
119052834  CXCL10; C-X-C motif chemokine 10 [KO:K12671]
119050515  ISG15; ubiquitin-like protein ISG15 [KO:K12159]
119057762  FAS; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
119041863  FADD; FAS-associated death domain protein [KO:K02373]
119065511  CASP8; caspase-8 [KO:K04398] [EC:3.4.22.61]
119044372  BID; BH3-interacting domain death agonist [KO:K04726]
119062736  BCL2L11; bcl-2-like protein 11 isoform X1 [KO:K16341]
119057575  BCL2; apoptosis regulator Bcl-2 isoform X1 [KO:K02161]
119037607  BAX; apoptosis regulator BAX isoform X1 [KO:K02159]
119041220  BAK1; bcl-2 homologous antagonist/killer isoform X1 [KO:K14021]
119035254  cytochrome c [KO:K08738]
119035643  cytochrome c-like [KO:K08738]
119060513  APAF1; apoptotic protease-activating factor 1 isoform X1 [KO:K02084]
119049966  CASP9; caspase-9 [KO:K04399] [EC:3.4.22.62]
119036917  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
119048495  uncharacterized protein LOC119048495 [KO:K10785]
119048496  uncharacterized protein LOC119048496 [KO:K10785]
119050802  CD3E; T-cell surface glycoprotein CD3 epsilon chain [KO:K06451]
119050803  CD3G; T-cell surface glycoprotein CD3 gamma chain isoform X1 [KO:K06452]
119050808  CD3D; T-cell surface glycoprotein CD3 delta chain isoform X1 [KO:K06450]
119065449  CD247; T-cell surface glycoprotein CD3 zeta chain isoform X1 [KO:K06453]
119065618  PSMC2; 26S proteasome regulatory subunit 7 [KO:K03061]
119037883  PSMC1; 26S proteasome regulatory subunit 4 [KO:K03062]
119053912  26S proteasome regulatory subunit 4 homolog A [KO:K03062]
119040442  PSMC4; 26S proteasome regulatory subunit 6B [KO:K03063]
119042328  26S proteasome regulatory subunit 6B homolog [KO:K03063]
119056989  PSMC6; 26S proteasome regulatory subunit 10B [KO:K03064]
119064475  PSMC3; 26S proteasome regulatory subunit 6A [KO:K03065]
119036290  PSMC5; 26S proteasome regulatory subunit 8 [KO:K03066]
119056444  PSMD2; 26S proteasome non-ATPase regulatory subunit 2 [KO:K03028]
119054299  PSMD1; 26S proteasome non-ATPase regulatory subunit 1 [KO:K03032]
119045752  PSMD3; 26S proteasome non-ATPase regulatory subunit 3 [KO:K03033]
119036277  PSMD12; 26S proteasome non-ATPase regulatory subunit 12 [KO:K03035]
119047838  PSMD11; 26S proteasome non-ATPase regulatory subunit 11 [KO:K03036]
119042405  PSMD6; 26S proteasome non-ATPase regulatory subunit 6 [KO:K03037]
119061931  PSMD7; 26S proteasome non-ATPase regulatory subunit 7 [KO:K03038]
119057991  26S proteasome non-ATPase regulatory subunit 7 homolog A [KO:K03038]
119060970  PSMD13; 26S proteasome non-ATPase regulatory subunit 13 [KO:K03039]
119035018  PSMD4; 26S proteasome non-ATPase regulatory subunit 4 isoform X1 [KO:K03029]
119045645  PSMD14; 26S proteasome non-ATPase regulatory subunit 14 isoform X1 [KO:K03030]
119057823  26S proteasome non-ATPase regulatory subunit 14 homolog [KO:K03030]
119046729  PSMD8; 26S proteasome non-ATPase regulatory subunit 8 [KO:K03031]
119055367  ADRM1; proteasomal ubiquitin receptor ADRM1 [KO:K06691]
119042895  SEM1; 26S proteasome complex subunit SEM1 [KO:K10881]
119062394  26S proteasome complex subunit SEM1-like [KO:K10881]
119049933  TAP1; antigen peptide transporter 1 isoform X1 [KO:K05653] [EC:7.4.2.14]
119049937  TAP2; antigen peptide transporter 2 [KO:K05654] [EC:7.4.2.14]
119041195  tapasin isoform X1 [KO:K08058]
119056491  PDIA3; protein disulfide-isomerase A3 [KO:K08056] [EC:5.3.4.1]
119054160  calreticulin-like [KO:K08057]
119054624  calreticulin-3-like [KO:K08057]
119049665  CALR; calreticulin [KO:K08057]
119064588  calreticulin-3-like [KO:K08057]
119035307  patr class I histocompatibility antigen, A-2 alpha chain-like isoform X1 [KO:K06751]
119035444  patr class I histocompatibility antigen, B-1 alpha chain-like [KO:K06751]
119035883  BOLA class I histocompatibility antigen, alpha chain BL3-7-like [KO:K06751]
119037417  saoe class I histocompatibility antigen, A alpha chain-like [KO:K06751]
119037803  HLA class I histocompatibility antigen, C alpha chain-like [KO:K06751]
119037804  patr class I histocompatibility antigen, alpha chain E-like [KO:K06751]
119037805  patr class I histocompatibility antigen, A-2 alpha chain-like [KO:K06751]
119037806  saoe class I histocompatibility antigen, A alpha chain-like [KO:K06751]
119037808  patr class I histocompatibility antigen, alpha chain E-like [KO:K06751]
119037809  patr class I histocompatibility antigen, A-126 alpha chain-like [KO:K06751]
119037811  class I histocompatibility antigen, Gogo-C*0202 alpha chain-like [KO:K06751]
119037812  HLA class I histocompatibility antigen, alpha chain F-like [KO:K06751]
119037813  saoe class I histocompatibility antigen, A alpha chain-like [KO:K06751]
119037822  patr class I histocompatibility antigen, A-108 alpha chain-like [KO:K06751]
119037824  HLA class I histocompatibility antigen, B alpha chain-like [KO:K06751]
119042380  BOLA class I histocompatibility antigen, alpha chain BL3-7-like [KO:K06751]
119058998  BOLA class I histocompatibility antigen, alpha chain BL3-7-like [KO:K06751]
119052950  HLA class I histocompatibility antigen, B alpha chain-like isoform X1 [KO:K06751]
119052964  HLA class I histocompatibility antigen, alpha chain G-like isoform X1 [KO:K06751]
119052978  HLA class I histocompatibility antigen, alpha chain F-like [KO:K06751]
119053723  patr class I histocompatibility antigen, A-126 alpha chain-like isoform X1 [KO:K06751]
119055211  class I histocompatibility antigen, Gogo-C*0202 alpha chain-like isoform X1 [KO:K06751]
119048072  HLA class I histocompatibility antigen, alpha chain G-like isoform X1 [KO:K06751]
119063032  patr class I histocompatibility antigen, A-126 alpha chain-like [KO:K06751]
119063033  HLA class I histocompatibility antigen, alpha chain G-like [KO:K06751]
119055989  LOW QUALITY PROTEIN: BOLA class I histocompatibility antigen, alpha chain BL3-7-like [KO:K06751]
119056406  patr class I histocompatibility antigen, A-126 alpha chain-like [KO:K06751]
119056410  patr class I histocompatibility antigen, A-126 alpha chain-like [KO:K06751]
119056413  LOW QUALITY PROTEIN: BOLA class I histocompatibility antigen, alpha chain BL3-7-like [KO:K06751]
119065069  H-2 class I histocompatibility antigen, alpha chain-like [KO:K06751]
119065880  patr class I histocompatibility antigen, A-2 alpha chain-like [KO:K06751]
119065881  patr class I histocompatibility antigen, A-2 alpha chain-like [KO:K06751]
119065882  patr class I histocompatibility antigen, A-2 alpha chain-like [KO:K06751]
119065883  HLA class I histocompatibility antigen, alpha chain G-like [KO:K06751]
119054162  B2M; beta-2-microglobulin [KO:K08055]
119049288  SNW1; SNW domain-containing protein 1 [KO:K06063]
119038476  SIN3A; paired amphipathic helix protein Sin3a [KO:K11644]
119051413  transcriptional regulatory protein SIN3-like [KO:K11644]
119057513  transcriptional regulatory protein SIN3-like [KO:K11644]
119038662  HDAC2; histone deacetylase 2 [KO:K06067] [EC:3.5.1.98]
119052290  HDAC1; histone deacetylase 1 [KO:K06067] [EC:3.5.1.98]
119060673  NCOR2; nuclear receptor corepressor 2 [KO:K06065]
119057554  SAP30; histone deacetylase complex subunit SAP30 [KO:K19202]
119057956  SAP30L; histone deacetylase complex subunit SAP30L [KO:K19202]
119053639  CIR1; corepressor interacting with RBPJ 1 [KO:K06066]
119063197  RBPJL; recombining binding protein suppressor of hairless-like protein [KO:K06053]
119057812  RBPJ; recombining binding protein suppressor of hairless isoform X1 [KO:K06053]
119055258  HES1; transcription factor HES-1 [KO:K06054]
119045316  FCER2; low affinity immunoglobulin epsilon Fc receptor isoform X1 [KO:K06468]
119042225  RUNX3; runt-related transcription factor 3 [KO:K09279]
119064823  MYC; myc proto-oncogene protein [KO:K04377]
119037043  ubiquitin carboxyl-terminal hydrolase 7-like [KO:K11838] [EC:3.4.19.12]
119041356  ubiquitin carboxyl-terminal hydrolase 7 [KO:K11838] [EC:3.4.19.12]
119041362  ubiquitin carboxyl-terminal hydrolase 7-like [KO:K11838] [EC:3.4.19.12]
119050597  ubiquitin carboxyl-terminal hydrolase 7-like [KO:K11838] [EC:3.4.19.12]
119052717  MDM2; E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:2.3.2.27]
119059042  cellular tumor antigen p53-like [KO:K04451]
119053542  TP53; cellular tumor antigen p53 [KO:K04451]
119050063  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
119043594  GADD45B; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
119063423  GADD45G; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
119049327  GADD45A; growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402]
119064434  DDB2; DNA damage-binding protein 2 isoform X1 [KO:K10140]
119048164  POLK; DNA polymerase kappa [KO:K03511] [EC:2.7.7.7]
119043073  TRAF5; TNF receptor-associated factor 5 isoform X1 [KO:K09849]
119043036  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
119044861  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
119064089  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
119052227  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
119053288  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
119046830  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
119040479  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
119053408  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
119063115  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
119061562  MAP3K14; mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
119051344  RELB; transcription factor RelB isoform X1 [KO:K09253]
119059672  NFKB2; nuclear factor NF-kappa-B p100 subunit isoform X1 [KO:K04469]
119061887  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein isoform X1 [KO:K03171]
119040143  NFKBIB; NF-kappa-B inhibitor beta [KO:K02581]
119047197  NFKBIE; NF-kappa-B inhibitor epsilon isoform X1 [KO:K05872]
119061575  LOW QUALITY PROTEIN: dual specificity mitogen-activated protein kinase kinase 4-like [KO:K04430] [EC:2.7.12.2]
119057169  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 isoform X1 [KO:K04430] [EC:2.7.12.2]
119059334  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
119042614  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
119046845  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
119062834  MAPK10; mitogen-activated protein kinase 10 [KO:K04440] [EC:2.7.11.24]
119036073  TRAF2; TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
119051788  RIPK1; receptor-interacting serine/threonine-protein kinase 1 isoform X1 [KO:K02861] [EC:2.7.11.1]
119062274  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 [KO:K04432] [EC:2.7.12.2]
119036284  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 isoform X1 [KO:K04433] [EC:2.7.12.2]
119060490  MAPK12; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
119060539  MAPK11; mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
119050071  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
119050081  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
119051654  JUN; transcription factor AP-1 [KO:K04448]
119036079  ENTPD8; ectonucleoside triphosphate diphosphohydrolase 8 isoform X1 [KO:K01510] [EC:3.6.1.5]
119044506  ENTPD1; ectonucleoside triphosphate diphosphohydrolase 1 isoform X1 [KO:K01510] [EC:3.6.1.5]
119051522  ENTPD3; ectonucleoside triphosphate diphosphohydrolase 3 [KO:K01510] [EC:3.6.1.5]
119063314  CD40; tumor necrosis factor receptor superfamily member 5 isoform X1 [KO:K03160]
119036453  CD44; CD44 antigen isoform X1 [KO:K06256]
119041144  ITGAL; integrin alpha-L isoform X1 [KO:K05718]
119041717  CD58; lymphocyte function-associated antigen 3 isoform X1 [KO:K06492]
119037076  ICAM1; intercellular adhesion molecule 1 [KO:K06490]
119061290  VIM; vimentin [KO:K07606]
119051859  TNFAIP3; tumor necrosis factor alpha-induced protein 3 isoform X1 [KO:K11859] [EC:3.4.19.12]
119046817  JAK3; tyrosine-protein kinase JAK3 [KO:K11218] [EC:2.7.10.2]
119052142  STAT3; signal transducer and activator of transcription 3 isoform X1 [KO:K04692]
119051466  LYN; tyrosine-protein kinase Lyn isoform X1 [KO:K05854] [EC:2.7.10.2]
119035131  SYK; tyrosine-protein kinase SYK isoform X1 [KO:K05855] [EC:2.7.10.2]
119053469  NEDD4; E3 ubiquitin-protein ligase NEDD4 isoform X1 [KO:K10591] [EC:2.3.2.26]
119041500  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
119051762  rho-related BTB domain-containing protein 1-like [KO:K04392]
119038485  BTK; tyrosine-protein kinase BTK [KO:K07370] [EC:2.7.10.2]
119044513  BLNK; B-cell linker protein isoform X1 [KO:K07371]
119047103  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
119037019  SKP2; S-phase kinase-associated protein 2 isoform X1 [KO:K03875]
119042826  CDKN1B; cyclin-dependent kinase inhibitor 1B [KO:K06624]
119041888  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
119054859  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
119056484  CCND3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
119065244  CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
119042716  CDK6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
119044365  CCNA1; cyclin-A1 [KO:K06627]
119037625  CCNA2; cyclin-A2 [KO:K06627]
119038552  CCNE2; G1/S-specific cyclin-E2 isoform X1 [KO:K06626]
119049234  CCNE1; G1/S-specific cyclin-E1 [KO:K06626]
119048545  CDK2; cyclin-dependent kinase 2 isoform X1 [KO:K02206] [EC:2.7.11.22]
119054193  RB1; retinoblastoma-associated protein isoform X1 [KO:K06618]
119047797  E2F1; transcription factor E2F1 [KO:K17454]
119042238  E2F2; transcription factor E2F2 isoform X1 [KO:K09389]
119055414  E2F3; transcription factor E2F3 isoform X1 [KO:K06620]
Compound
C00076  Calcium cation
C01245  D-myo-Inositol 1,4,5-trisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:15510157
  Authors
Young LS, Rickinson AB.
  Title
Epstein-Barr virus: 40 years on.
  Journal
Nat Rev Cancer 4:757-68 (2004)
DOI:10.1038/nrc1452
Reference
PMID:21372216
  Authors
Saha A, Robertson ES
  Title
Epstein-Barr virus-associated B-cell lymphomas: pathogenesis and clinical outcomes.
  Journal
Clin Cancer Res 17:3056-63 (2011)
DOI:10.1158/1078-0432.CCR-10-2578
Reference
PMID:21429244
  Authors
Ning S
  Title
Innate immune modulation in EBV infection.
  Journal
Herpesviridae 2:1 (2011)
DOI:10.1186/2042-4280-2-1
Reference
PMID:28408983
  Authors
Stanfield BA, Luftig MA
  Title
Recent advances in understanding Epstein-Barr virus.
  Journal
F1000Res 6:386 (2017)
DOI:10.12688/f1000research.10591.1
Reference
PMID:24586164
  Authors
van Gent M, Braem SG, de Jong A, Delagic N, Peeters JG, Boer IG, Moynagh PN, Kremmer E, Wiertz EJ, Ovaa H, Griffin BD, Ressing ME
  Title
Epstein-Barr virus large tegument protein BPLF1 contributes to innate immune evasion through interference with toll-like receptor signaling.
  Journal
PLoS Pathog 10:e1003960 (2014)
DOI:10.1371/journal.ppat.1003960
Reference
PMID:23850008
  Authors
Rajsbaum R, Garcia-Sastre A
  Title
Viral evasion mechanisms of early antiviral responses involving regulation of ubiquitin pathways.
  Journal
Trends Microbiol 21:421-9 (2013)
DOI:10.1016/j.tim.2013.06.006
Reference
PMID:25704559
  Authors
Hoffmann HH, Schneider WM, Rice CM
  Title
Interferons and viruses: an evolutionary arms race of molecular interactions.
  Journal
Trends Immunol 36:124-38 (2015)
DOI:10.1016/j.it.2015.01.004
Reference
PMID:22110506
  Authors
Spender LC, Inman GJ
  Title
Inhibition of germinal centre apoptotic programmes by epstein-barr virus.
  Journal
Adv Hematol 2011:829525 (2011)
DOI:10.1155/2011/829525
Reference
PMID:23303627
  Authors
Fu Q, He C, Mao ZR
  Title
Epstein-Barr virus interactions with the Bcl-2 protein family and apoptosis in human tumor cells.
  Journal
J Zhejiang Univ Sci B 14:8-24 (2013)
DOI:10.1631/jzus.B1200189
Reference
PMID:29116588
  Authors
Wang Y, Banerjee S, Ding L, Cai C, Wei F, Cai Q
  Title
The regulatory role of protein phosphorylation in human gammaherpesvirus associated cancers.
  Journal
Virol Sin 32:357-368 (2017)
DOI:10.1007/s12250-017-4081-9
Reference
PMID:23435233
  Authors
Melchjorsen J
  Title
Learning from the messengers: innate sensing of viruses and cytokine regulation of immunity - clues for treatments and vaccines.
  Journal
Viruses 5:470-527 (2013)
DOI:10.3390/v5020470
Reference
PMID:19498380
  Authors
Hansen TH, Bouvier M
  Title
MHC class I antigen presentation: learning from viral evasion strategies.
  Journal
Nat Rev Immunol 9:503-13 (2009)
DOI:10.1038/nri2575
Reference
PMID:18977445
  Authors
Ressing ME, Horst D, Griffin BD, Tellam J, Zuo J, Khanna R, Rowe M, Wiertz EJ
  Title
Epstein-Barr virus evasion of CD8(+) and CD4(+) T cell immunity via concerted actions of multiple gene products.
  Journal
Semin Cancer Biol 18:397-408 (2008)
DOI:10.1016/j.semcancer.2008.10.008
Reference
PMID:21146386
  Authors
Horst D, Verweij MC, Davison AJ, Ressing ME, Wiertz EJ
  Title
Viral evasion of T cell immunity: ancient mechanisms offering new applications.
  Journal
Curr Opin Immunol 23:96-103 (2011)
DOI:10.1016/j.coi.2010.11.005
Reference
PMID:27886133
  Authors
Ghosh Roy S, Robertson ES, Saha A
  Title
Epigenetic Impact on EBV Associated B-Cell Lymphomagenesis.
  Journal
Biomolecules 6:E46 (2016)
DOI:10.3390/biom6040046
Reference
PMID:22249143
  Authors
Dawson CW, Port RJ, Young LS
  Title
The role of the EBV-encoded latent membrane proteins LMP1 and LMP2 in the pathogenesis of nasopharyngeal carcinoma (NPC).
  Journal
Semin Cancer Biol 22:144-53 (2012)
DOI:10.1016/j.semcancer.2012.01.004
Reference
PMID:25613730
  Authors
Cai Q, Chen K, Young KH
  Title
Epstein-Barr virus-positive T/NK-cell lymphoproliferative disorders.
  Journal
Exp Mol Med 47:e133 (2015)
DOI:10.1038/emm.2014.105
Reference
PMID:17601372
  Authors
Zheng H, Li LL, Hu DS, Deng XY, Cao Y
  Title
Role of Epstein-Barr virus encoded latent membrane protein 1 in the carcinogenesis of nasopharyngeal carcinoma.
  Journal
Cell Mol Immunol 4:185-96 (2007)
Reference
PMID:23793113
  Authors
Ersing I, Bernhardt K, Gewurz BE
  Title
NF-kappaB and IRF7 pathway activation by Epstein-Barr virus Latent Membrane Protein 1.
  Journal
Viruses 5:1587-606 (2013)
DOI:10.3390/v5061587
Reference
PMID:28835489
  Authors
Wang LW, Jiang S, Gewurz BE
  Title
Epstein-Barr Virus LMP1-Mediated Oncogenicity.
  Journal
J Virol 91:e01718-16 (2017)
DOI:10.1128/JVI.01718-16
Reference
PMID:12740915
  Authors
Mori N, Morishita M, Tsukazaki T, Yamamoto N
  Title
Repression of Smad-dependent transforming growth factor-beta signaling by Epstein-Barr virus latent membrane protein 1 through nuclear factor-kappaB.
  Journal
Int J Cancer 105:661-8 (2003)
DOI:10.1002/ijc.11146
Reference
PMID:25873381
  Authors
Edwards RH, Marquitz AR, Raab-Traub N
  Title
Changes in expression induced by Epstein-Barr Virus LMP1-CTAR1: potential role of bcl3.
  Journal
MBio 6:e00441-15 (2015)
DOI:10.1128/mBio.00441-15
Reference
PMID:11905817
  Authors
Thorley-Lawson DA
  Title
Epstein-Barr virus: exploiting the immune system.
  Journal
Nat Rev Immunol 1:75-82 (2001)
DOI:10.1038/35095584
Reference
PMID:11669605
  Authors
Eliopoulos AG, Young LS
  Title
LMP1 structure and signal transduction.
  Journal
Semin Cancer Biol 11:435-44 (2001)
DOI:10.1006/scbi.2001.0410
Reference
PMID:14506283
  Authors
Holowaty MN, Sheng Y, Nguyen T, Arrowsmith C, Frappier L
  Title
Protein interaction domains of the ubiquitin-specific protease, USP7/HAUSP.
  Journal
J Biol Chem 278:47753-61 (2003)
DOI:10.1074/jbc.M307200200
Reference
PMID:25403939
  Authors
Kang H, Kiess A, Chung CH
  Title
Emerging biomarkers in head and neck cancer in the era of genomics.
  Journal
Nat Rev Clin Oncol 12:11-26 (2015)
DOI:10.1038/nrclinonc.2014.192
Reference
PMID:29932446
  Authors
Tornesello ML, Annunziata C, Tornesello AL, Buonaguro L, Buonaguro FM
  Title
Human Oncoviruses and p53 Tumor Suppressor Pathway Deregulation at the Origin of Human Cancers.
  Journal
Cancers (Basel) 10:E213 (2018)
DOI:10.3390/cancers10070213
Reference
PMID:19649319
  Authors
Sato Y, Kamura T, Shirata N, Murata T, Kudoh A, Iwahori S, Nakayama S, Isomura H, Nishiyama Y, Tsurumi T
  Title
Degradation of phosphorylated p53 by viral protein-ECS E3 ligase complex.
  Journal
PLoS Pathog 5:e1000530 (2009)
DOI:10.1371/journal.ppat.1000530
Reference
PMID:19244339
  Authors
Saha A, Murakami M, Kumar P, Bajaj B, Sims K, Robertson ES
  Title
Epstein-Barr virus nuclear antigen 3C augments Mdm2-mediated p53 ubiquitination and degradation by deubiquitinating Mdm2.
  Journal
J Virol 83:4652-69 (2009)
DOI:10.1128/JVI.02408-08
Reference
PMID:19394062
  Authors
Yi F, Saha A, Murakami M, Kumar P, Knight JS, Cai Q, Choudhuri T, Robertson ES
  Title
Epstein-Barr virus nuclear antigen 3C targets p53 and modulates its transcriptional and apoptotic activities.
  Journal
Virology 388:236-47 (2009)
DOI:10.1016/j.virol.2009.03.027
Reference
PMID:25635182
  Authors
Kumar P, Murakami M, Kaul R, Saha A, Cai Q, Robertson ES
  Title
Deregulation of the cell cycle machinery by Epstein-Barr virus nuclear antigen 3C.
  Journal
Future Virol 4:79-91 (2009)
DOI:10.2217/17460794.4.1.79
Reference
PMID:10818681
  Authors
Longnecker R
  Title
Epstein-Barr virus latency: LMP2, a regulator or means for Epstein-Barr virus persistence?
  Journal
Adv Cancer Res 79:175-200 (2000)
DOI:10.1016/s0065-230x(00)79006-3
Reference
PMID:30116721
  Authors
El-Sharkawy A, Al Zaidan L, Malki A
  Title
Epstein-Barr Virus-Associated Malignancies: Roles of Viral Oncoproteins in Carcinogenesis.
  Journal
Front Oncol 8:265 (2018)
DOI:10.3389/fonc.2018.00265
Reference
PMID:12811813
  Authors
Dolcetti R, Masucci MG
  Title
Epstein-Barr virus: induction and control of cell transformation.
  Journal
J Cell Physiol 196:207-18 (2003)
DOI:10.1002/jcp.10263
Reference
PMID:21347341
  Authors
Saha A, Halder S, Upadhyay SK, Lu J, Kumar P, Murakami M, Cai Q, Robertson ES
  Title
Epstein-Barr virus nuclear antigen 3C facilitates G1-S transition by stabilizing and enhancing the function of cyclin D1.
  Journal
PLoS Pathog 7:e1001275 (2011)
DOI:10.1371/journal.ppat.1001275
Related
pathway
ajm03050  Proteasome
ajm04010  MAPK signaling pathway
ajm04020  Calcium signaling pathway
ajm04064  NF-kappa B signaling pathway
ajm04110  Cell cycle
ajm04115  p53 signaling pathway
ajm04210  Apoptosis
ajm04612  Antigen processing and presentation
ajm04620  Toll-like receptor signaling pathway
ajm04622  RIG-I-like receptor signaling pathway
ajm04630  JAK-STAT signaling pathway
ajm04662  B cell receptor signaling pathway
KO pathway
ko05169   
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