Entry Name Rap1 signaling pathway - Arvicanthis niloticus (African grass rat)
Description Rap1 is a small GTPase that controls diverse processes, such as cell adhesion, cell-cell junction formation and cell polarity. Like all G proteins, Rap1 cycles between an inactive GDP-bound and an active GTP-bound conformation. A variety of extracellular signals control this cycle through the regulation of several unique guanine nucleotide exchange factors (GEFs) and GTPase activating proteins (GAPs). Rap1 plays a dominant role in the control of cell-cell and cell-matrix interactions by regulating the function of integrins and other adhesion molecules in various cell types. Rap1 also regulates MAP kinase (MAPK) activity in a manner highly dependent on the context of cell types.
Class Environmental Information Processing; Signal transductionBRITE hierarchy
Pathway map Other DBs Organism Arvicanthis niloticus (African grass rat) [GN:
anu ]
Gene 117693315 Gnai2; guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630 ]
117693421 Pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922 ] [EC:2.7.1.153 ]
117693614 Lat; linker for activation of T-cells family member 1 [KO:K07362 ]
117695345 Vegfd; vascular endothelial growth factor D isoform X1 [KO:K05449 ]
117697183 Sipa1l1; signal-induced proliferation-associated 1-like protein 1 isoform X1 [KO:K17701 ]
117697870 Rac1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392 ]
117698163 Pdgfa; platelet-derived growth factor subunit A isoform X1 [KO:K04359 ]
117703002 Rapgef1; rap guanine nucleotide exchange factor 1 isoform X1 [KO:K06277 ]
117703017 Plcb4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858 ] [EC:3.1.4.11 ]
117703098 Rapgef4; rap guanine nucleotide exchange factor 4 isoform X1 [KO:K04351 ]
117703478 Ralgds; ral guanine nucleotide dissociation stimulator isoform X1 [KO:K08732 ]
117703529 Plcb2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858 ] [EC:3.1.4.11 ]
117703912 Vav2; guanine nucleotide exchange factor VAV2 isoform X1 [KO:K05730 ]
117704526 Pard6b; partitioning defective 6 homolog beta isoform X1 [KO:K06093 ]
117704993 Plce1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X1 [KO:K05860 ] [EC:3.1.4.11 ]
117705469 Gnaq; guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634 ]
117705590 Sipa1l3; signal-induced proliferation-associated 1-like protein 3 isoform X1 [KO:K17703 ]
117706649 Pik3ca; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922 ] [EC:2.7.1.153 ]
117706806 Magi3; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 3 isoform X1 [KO:K06112 ]
117706851 Gnai3; guanine nucleotide-binding protein G(i) subunit alpha [KO:K04630 ]
117706885 Csf1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453 ]
117707010 Vav3; guanine nucleotide exchange factor VAV3 isoform X1 [KO:K05730 ]
117707165 Rapgef2; rap guanine nucleotide exchange factor 2 isoform X1 [KO:K08018 ]
117708461 Cdc42; cell division control protein 42 homolog isoform X1 [KO:K04393 ]
117708986 Pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922 ] [EC:2.7.1.153 ]
117710141 Grin1; glutamate receptor ionotropic, NMDA 1 isoform X1 [KO:K05208 ]
117711427 Rapgef6; rap guanine nucleotide exchange factor 6 isoform X1 [KO:K08020 ]
117711825 Ngfr; tumor necrosis factor receptor superfamily member 16 [KO:K02583 ]
117712005 Plcb3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform X1 [KO:K05858 ] [EC:3.1.4.11 ]
117713496 Apbb1ip; amyloid beta A4 precursor protein-binding family B member 1-interacting protein [KO:K17704 ]
117714048 Rgs14; regulator of G-protein signaling 14 isoform X1 [KO:K17706 ]
117714733 Magi1; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X1 [KO:K05631 ]
117716334 Vegfb; vascular endothelial growth factor B isoform X1 [KO:K16858 ]
117716499 Rassf5; ras association domain-containing protein 5 isoform X1 [KO:K08015 ]
117717352 Vasp; vasodilator-stimulated phosphoprotein isoform X1 [KO:K06274 ]
117717813 Tiam1; LOW QUALITY PROTEIN: T-lymphoma invasion and metastasis-inducing protein 1 [KO:K05731 ]
117719827 Arap3; arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 [KO:K12490 ]
117720485 Magi2; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 [KO:K05629 ]
117720623 Gnai1; guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630 ]
117721973 Pik3r2; phosphatidylinositol 3-kinase regulatory subunit beta isoform X1 [KO:K02649 ]
117722213 Vegfa; vascular endothelial growth factor A isoform X1 [KO:K05448 ]
117722317 Farp2; FERM, ARHGEF and pleckstrin domain-containing protein 2 isoform X1 [KO:K06082 ]
117722663 Sipa1; signal-induced proliferation-associated protein 1 [KO:K08013 ]
117722995 Gnao1; guanine nucleotide-binding protein G(o) subunit alpha isoform X1 [KO:K04534 ]
117723039 Bcar1; breast cancer anti-estrogen resistance protein 1 isoform X1 [KO:K05726 ]
117723177 Sipa1l2; signal-induced proliferation-associated 1-like protein 2 isoform X1 [KO:K17702 ]
117723270 Pard6a; partitioning defective 6 homolog alpha isoform X1 [KO:K06093 ]
117723761 Pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649 ]
Compound Reference Authors Kooistra MR, Dube N, Bos JL
Title Rap1: a key regulator in cell-cell junction formation.
Journal Reference Authors Bos JL, de Rooij J, Reedquist KA
Title Rap1 signalling: adhering to new models.
Journal Reference Authors Minato N, Kometani K, Hattori M
Title Regulation of immune responses and hematopoiesis by the Rap1 signal.
Journal Reference Authors Bos JL
Title Linking Rap to cell adhesion.
Journal Reference Authors Caron E
Title Cellular functions of the Rap1 GTP-binding protein: a pattern emerges.
Journal Reference Authors Zwartkruis FJ, Bos JL
Title Ras and Rap1: two highly related small GTPases with distinct function.
Journal Reference Authors Hattori M, Minato N
Title Rap1 GTPase: functions, regulation, and malignancy.
Journal Reference Authors Pannekoek WJ, Kooistra MR, Zwartkruis FJ, Bos JL
Title Cell-cell junction formation: the role of Rap1 and Rap1 guanine nucleotide exchange factors.
Journal Reference Authors Boettner B, Van Aelst L
Title Control of cell adhesion dynamics by Rap1 signaling.
Journal Reference Authors Xia Z, Storm DR.
Title The role of calmodulin as a signal integrator for synaptic plasticity.
Journal Reference Authors Mor A, Dustin ML, Philips MR
Title Small GTPases and LFA-1 reciprocally modulate adhesion and signaling.
Journal Reference Authors Burbach BJ, Medeiros RB, Mueller KL, Shimizu Y
Title T-cell receptor signaling to integrins.
Journal Reference Authors Stork PJ
Title Does Rap1 deserve a bad Rap?
Journal Reference Authors Banihashemi B, Albert PR
Title Dopamine-D2S receptor inhibition of calcium influx, adenylyl cyclase, and mitogen-activated protein kinase in pituitary cells: distinct Galpha and Gbetagamma requirements.
Journal Reference Authors Banno A, Ginsberg MH
Title Integrin activation.
Journal Reference Authors Doebele RC, Schulze-Hoepfner FT, Hong J, Chlenski A, Zeitlin BD, Goel K, Gomes S, Liu Y, Abe MK, Nor JE, Lingen MW, Rosner MR
Title A novel interplay between Epac/Rap1 and mitogen-activated protein kinase kinase 5/extracellular signal-regulated kinase 5 (MEK5/ERK5) regulates thrombospondin to control angiogenesis.
Journal Reference Authors Breckler M, Berthouze M, Laurent AC, Crozatier B, Morel E, Lezoualc'h F
Title Rap-linked cAMP signaling Epac proteins: compartmentation, functioning and disease implications.
Journal Related anu04660 T cell receptor signaling pathway
anu04810 Regulation of actin cytoskeleton
KO pathway
