KEGG   PATHWAY: ecb05206
Entry
ecb05206                    Pathway                                
Name
MicroRNAs in cancer - Equus caballus (horse)
Description
MicroRNA (miRNA) is a cluster of small non-encoding RNA molecules of 21 - 23 nucleotides in length, which controls gene expression post-transcriptionally either via the degradation of target mRNAs or the inhibition of protein translation. Using high-throughput profiling, dysregulation of miRNAs has been widely observed in different stages of cancer. The upregulation (overexpression) of specific miRNAs could lead to the repression of tumor suppressor gene expression, and conversely the downregulation of specific miRNAs could result in an increase of oncogene expression; both these situations induce subsequent malignant effects on cell proliferation, differentiation, and apoptosis that lead to tumor growth and progress. The miRNA signatures of cancer observed in various studies differ significantly. These inconsistencies occur due to the differences in the study populations and methodologies used. This pathway map shows the summarized results from various studies in 9 cancers, each of which is presented in a review article.
Class
Human Diseases; Cancer: overview
Pathway map
ecb05206  MicroRNAs in cancer
ecb05206

Organism
Equus caballus (horse) [GN:ecb]
Gene
100314982  MIR17; eca-miR-17 [KO:K17002]
100315069  MIR18A; eca-miR-18a [KO:K17003]
100314874  MIR19A; eca-miR-19a [KO:K17005]
100314937  MIR19B-2; eca-miR-19b [KO:K23559]
100315018  MIR19B; eca-miR-19b [KO:K23559]
100314875  MIR20A; eca-miR-20a [KO:K17006]
100314876  MIR92A; eca-miR-92a [KO:K17008]
100315098  MIR92A-2; eca-miR-92a [KO:K17008]
100062388  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
100314997  MIR221; eca-miR-221 [KO:K17010]
100314938  MIR222; eca-miR-222 [KO:K17011]
111773925  CDKN1B; cyclin-dependent kinase inhibitor 1B [KO:K06624]
100314844  MIR21; eca-miR-21 [KO:K16863]
100033947  TIMP3; metalloproteinase inhibitor 3 precursor [KO:K16866]
100315027  MIRLET7A-2; eca-let-7a [KO:K16980]
100314820  MIRLET7A; eca-let-7a [KO:K16980]
100314889  MIRLET7D; eca-let-7d [KO:K16980]
100314974  MIRLET7E; eca-let-7e [KO:K16980]
100315074  MIRLET7F; eca-let-7f [KO:K16980]
100314867  MIRLET7G; eca-let-7g [KO:K16980]
100315026  MIRLET7C; eca-let-7c [KO:K17397]
100064473  KRAS; GTPase KRas isoform X1 [KO:K07827]
100051785  LOW QUALITY PROTEIN: GTPase KRas-like [KO:K07827]
100061625  CDK6; cyclin-dependent kinase 6 isoform X1 [KO:K02091] [EC:2.7.11.22]
100064223  CDC25A; M-phase inducer phosphatase 1 [KO:K06645] [EC:3.1.3.48]
100052425  CDC25B; M-phase inducer phosphatase 2 [KO:K05866] [EC:3.1.3.48]
100062352  CDC25C; M-phase inducer phosphatase 3 isoform X3 [KO:K05867] [EC:3.1.3.48]
102149270  HMGA2; high mobility group protein HMGI-C isoform X1 [KO:K09283]
100314773  MIR107B; eca-miR-107b [KO:K17396]
100315064  MIR107A; eca-miR-107a [KO:K17396]
100314872  MIR15A; eca-miR-15a [KO:K16986]
100314806  MIR15B; eca-miR-15b [KO:K16987]
100314807  MIR16-1; eca-miR-16 [KO:K16988]
100314873  MIR16-2; eca-miR-16 [KO:K16988]
102149114  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
100051150  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
100055302  CCNE2; G1/S-specific cyclin-E2 isoform X1 [KO:K06626]
100053882  CCNE1; G1/S-specific cyclin-E1 [KO:K06626]
100315085  MIR126; eca-miR-126-5p [KO:K16978]
100072356  CRK; adapter molecule crk isoform X1 [KO:K04438]
100050855  CRKL; crk-like protein [KO:K04438]
100314885  MIR1-2; eca-miR-1 [KO:K16972]
100314828  MIR1-1; eca-miR-1 [KO:K16972]
100051252  HDAC5; histone deacetylase 5 isoform X1 [KO:K11406] [EC:3.5.1.98]
100067014  HDAC4; histone deacetylase 4 isoform X1 [KO:K11406] [EC:3.5.1.98]
100053199  FOXP1; forkhead box protein P1 isoform X1 [KO:K23582]
100053898  PIM1; serine/threonine-protein kinase pim-1 [KO:K04702] [EC:2.7.11.1]
100056013  MET; hepatocyte growth factor receptor precursor [KO:K05099] [EC:2.7.10.1]
100314800  MIR29A; eca-miR-29a [KO:K16995]
100315043  MIR29B; eca-miR-29b [KO:K16996]
100315047  MIR29B-2; eca-miR-29b [KO:K16996]
100314812  MIR29C; eca-miR-29c [KO:K16997]
100315101  MIR29C-2; eca-miR-29c [KO:K16997]
100055881  DNMT3A; DNA (cytosine-5)-methyltransferase 3A isoform X1 [KO:K17398] [EC:2.1.1.37]
100053900  DNMT3B; DNA (cytosine-5)-methyltransferase 3B isoform X1 [KO:K17399] [EC:2.1.1.37]
100315073  MIR133A-2; eca-miR-133a [KO:K16970]
100315053  MIR133A; eca-miR-133a [KO:K16970]
100315071  MIR133B; eca-miR-133b [KO:K16971]
100054765  MCL1; induced myeloid leukemia cell differentiation protein Mcl-1 [KO:K02539]
100055644  BCL2L2; bcl-2-like protein 2 [KO:K02163]
100315015  MIR145; eca-miR-145 [KO:K16974]
100067755  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
100033839  VEGFA; vascular endothelial growth factor A precursor [KO:K05448]
100315006  MIR200C; eca-miR-200c [KO:K17017]
100062264  ZEB1; zinc finger E-box-binding homeobox 1 isoform X4 [KO:K09299]
100315033  MIR141; eca-miR-141 [KO:K17018]
100050377  TGFB2; transforming growth factor beta-2 isoform X2 [KO:K13376]
111771316  transforming growth factor beta-2-like isoform X1 [KO:K13376]
100314799  MIR183; eca-miR-183 [KO:K17116]
100059467  EZR; ezrin [KO:K08007]
100314835  MIR125A; eca-miR-125a-5p [KO:K16993]
100314821  MIR125B; eca-miR-125b-5p [KO:K16994]
100314924  MIR125B-2; eca-miR-125b-5p [KO:K16994]
100059302  PDCD4; programmed cell death protein 4 isoform X1 [KO:K16865]
100314979  MIR143; eca-miR-143 [KO:K17023]
100314852  MIR192; eca-miR-192 [KO:K17131]
100314853  MIR194-1; eca-miR-194 [KO:K17371]
100314930  MIR194-2; eca-miR-194 [KO:K17371]
100055626  EP300; histone acetyltransferase p300 isoform X2 [KO:K04498] [EC:2.3.1.48]
100069613  CREBBP; CREB-binding protein isoform X1 [KO:K04498] [EC:2.3.1.48]
100314931  MIR215; eca-miR-215 [KO:K17167]
100314878  MIR28; eca-miR-28-5p [KO:K17366]
100314834  MIR30D; eca-miR-30d [KO:K17110]
100315112  MIR30E; eca-miR-30e [KO:K17110]
100315055  MIR30B; eca-miR-30b [KO:K17111]
100314984  MIR30C-2; eca-miR-30c [KO:K17040]
100315039  MIR30C; eca-miR-30c [KO:K17040]
100067330  TPM1; tropomyosin alpha-1 chain isoform X1 [KO:K10373]
100050086  SPRY2; protein sprouty homolog 2 [KO:K17383]
100050934  BCL2; apoptosis regulator Bcl-2 isoform X1 [KO:K02161]
100051081  SERPINB5; serpin B5 [KO:K10139]
100314994  MIR155; eca-miR-155 [KO:K17009]
100314810  MIR205; eca-miR-205 [KO:K17150]
100072676  ST14; suppressor of tumorigenicity 14 protein [KO:K08670] [EC:3.4.21.109]
100070088  CYP1B1; cytochrome P450 1B1 [KO:K07410] [EC:1.14.14.1]
100315075  MIR31; eca-miR-31 [KO:K17183]
100314926  MIR99A-2; eca-miR-99a [KO:K17367]
100315050  MIR100; eca-miR-100 [KO:K17041]
100051341  MTOR; serine/threonine-protein kinase mTOR isoform X3 [KO:K07203] [EC:2.7.11.1]
100056244  RPTOR; regulatory-associated protein of mTOR isoform X10 [KO:K07204]
100053452  CYP24A1; 1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial [KO:K07436] [EC:1.14.15.16]
100054739  ERBB2; receptor tyrosine-protein kinase erbB-2 isoform X1 [KO:K05083] [EC:2.7.10.1]
100059216  ERBB3; receptor tyrosine-protein kinase erbB-3 [KO:K05084] [EC:2.7.10.1]
100069715  ABL1; tyrosine-protein kinase ABL1 isoform X1 [KO:K06619] [EC:2.7.10.2]
100059752  TP63; tumor protein 63 isoform X4 [KO:K10149]
100057772  ZEB2; zinc finger E-box-binding homeobox 2 isoform X1 [KO:K23560]
100146921  FSCN1; fascin [KO:K23551]
100061779  RASSF1; ras association domain-containing protein 1 isoform X1 [KO:K09850]
100314983  MIR10B; eca-miR-10b [KO:K17393]
100066123  HOXD10; homeobox protein Hox-D10 [KO:K09295]
100072811  DDIT4; DNA damage-inducible transcript 4 protein [KO:K08270]
100057359  BMF; LOW QUALITY PROTEIN: bcl-2-modifying factor [KO:K17460]
100314939  MIR224; eca-miR-224 [KO:K17042]
100067000  PAK4; serine/threonine-protein kinase PAK 4 isoform X1 [KO:K05734] [EC:2.7.11.1]
100056599  MMP9; matrix metalloproteinase-9 precursor [KO:K01403] [EC:3.4.24.35]
100315092  MIR363; eca-miR-363 [KO:K17036]
100314915  MIR494; eca-miR-494 [KO:K17378]
100314970  MIR615; eca-miR-615-5p [KO:K17380]
100314978  MIR25; eca-miR-25 [KO:K17038]
100314788  MIR34A; eca-miR-34a [KO:K16982]
100314804  MIR96; eca-miR-96 [KO:K17114]
100315057  MIR10A; eca-miR-10a [KO:K16864]
100314823  MIR23A; eca-miR-23a [KO:K17165]
100314890  MIR23B; eca-miR-23b [KO:K17394]
100315102  MIR122; eca-miR-122 [KO:K17020]
100063073  SLC7A1; high affinity cationic amino acid transporter 1 [KO:K13863]
100059534  CCNG1; cyclin-G1 [KO:K10145]
100069058  HMOX1; heme oxygenase 1 [KO:K00510] [EC:1.14.14.18]
100315010  MIR150; eca-miR-150 [KO:K17024]
100315091  MIR223; eca-miR-223 [KO:K17001]
100057411  STMN1; stathmin [KO:K04381]
100314902  MIR342; eca-miR-342-5p [KO:K17132]
100314848  MIR423; eca-miR-423-5p [KO:K17376]
100034011  STAT3; signal transducer and activator of transcription 3 [KO:K04692]
100068097  MYC; myc proto-oncogene protein [KO:K04377]
100034083  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
100055481  HRAS; GTPase HRas isoform X1 [KO:K02833]
100059469  NRAS; GTPase NRas [KO:K07828]
100314922  MIR199B; eca-miR-199b-5p [KO:K17119]
100314846  MIR324; eca-miR-324-5p [KO:K17152]
104797069  MIR483; eca-miR-483 [KO:K17137]
100314870  MIR26A-2; eca-miR-26a [KO:K16984]
100314818  MIR26A; eca-miR-26a [KO:K16984]
100058341  DNMT1; DNA (cytosine-5)-methyltransferase 1 isoform X1 [KO:K00558] [EC:2.1.1.37]
100315045  MIR135B; eca-miR-135b [KO:K17144]
100314869  MIR135A; eca-miR-135a [KO:K17144]
100314995  MIR135A-2; eca-miR-135a [KO:K17144]
100064431  APC; adenomatous polyposis coli protein [KO:K02085]
100147102  APC2; adenomatous polyposis coli protein 2 isoform X1 [KO:K02085]
100061987  IRS1; insulin receptor substrate 1 [KO:K16172]
100052122  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
100050227  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X3 [KO:K02649]
100146348  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
100073174  MAPK7; mitogen-activated protein kinase 7 isoform X1 [KO:K04464] [EC:2.7.11.24]
100051623  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
100058141  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
100051753  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
100314784  MIR200A; eca-miR-200a [KO:K17015]
100315038  MIR200B; eca-miR-200b [KO:K17016]
100052735  HNRNPK; heterogeneous nuclear ribonucleoprotein K [KO:K12886]
100067290  RECK; reversion-inducing cysteine-rich protein with Kazal motifs isoform X4 [KO:K17461]
106782583  reversion-inducing cysteine-rich protein with Kazal motifs-like [KO:K17461]
100314968  MIR137; eca-miR-137 [KO:K17369]
100314868  MIR128-1; eca-miR-128 [KO:K17130]
100315070  MIR128-2; eca-miR-128 [KO:K17130]
100052248  E2F3; transcription factor E2F3 isoform X1 [KO:K06620]
100314782  MIR7-1; eca-miR-7 [KO:K17365]
100314894  MIR7-3; eca-miR-7 [KO:K17365]
100315008  MIR7-2; eca-miR-7 [KO:K17365]
100146249  IRS2; insulin receptor substrate 2 isoform X1 [KO:K07187]
100314825  MIR326; eca-miR-326 [KO:K17372]
100068764  NOTCH1; neurogenic locus notch homolog protein 1 [KO:K02599]
100067078  NOTCH2; neurogenic locus notch homolog protein 2 [KO:K20994]
100146771  NOTCH3; neurogenic locus notch homolog protein 3 [KO:K20995]
100059541  NOTCH4; neurogenic locus notch homolog protein 4 isoform X1 [KO:K20996]
102148742  polycomb complex protein BMI-1 [KO:K11459]
100314861  MIR146A; eca-miR-146a [KO:K17012]
100049862  MMP16; matrix metalloproteinase-16 [KO:K07996] [EC:3.4.24.-]
100314921  MIR181A; eca-miR-181a [KO:K17025]
100315088  MIR181A-2; eca-miR-181a [KO:K17025]
100314993  MIR181B; eca-miR-181b [KO:K17026]
100061765  ATM; serine-protein kinase ATM [KO:K04728] [EC:2.7.11.1]
102148488  SOCS1; suppressor of cytokine signaling 1 [KO:K04694]
100034221  CD44; CD44 antigen precursor [KO:K06256]
100314886  MIR103; eca-miR-103 [KO:K16989]
100065648  DICER1; endoribonuclease Dicer isoform X1 [KO:K11592] [EC:3.1.26.-]
100054732  FZD3; frizzled-3 [KO:K02329]
100064655  ITGA5; integrin alpha-5 [KO:K06484]
100061858  RDX; radixin isoform X3 [KO:K05762]
100053343  RHOA; transforming protein RhoA [KO:K04513]
100314857  MIR193B; eca-miR-193b [KO:K17148]
100072886  PLAU; urokinase-type plasminogen activator [KO:K01348] [EC:3.4.21.73]
100061755  BAK1; bcl-2 homologous antagonist/killer [KO:K14021]
100063119  ZFPM2; zinc finger protein ZFPM2 [KO:K17442]
111774999  zinc finger protein ZFPM2 isoform X1 [KO:K17442]
100009709  ITGB3; integrin beta-3 precursor [KO:K06493]
100065385  UBE2I; SUMO-conjugating enzyme UBC9 [KO:K10577]
100314801  MIR335; eca-miR-335 [KO:K17033]
111769285  SOX4; transcription factor SOX-4 [KO:K23581]
100061556  TNN; tenascin-N isoform X3 [KO:K06252]
100061691  TNR; tenascin-R isoform X1 [KO:K06252]
100049835  TNC; tenascin isoform X1 [KO:K06252]
100059315  TNXB; tenascin-X isoform X7 [KO:K06252]
100314880  MIR206-2; eca-miR-206 [KO:K16973]
100315060  MIR451; eca-miR-451 [KO:K17172]
100034074  ABCB1; multidrug resistance protein 1 [KO:K05658] [EC:7.6.2.2]
100314989  MIR345; eca-miR-345-5p [KO:K17375]
791240  ABCC1; multidrug resistance-associated protein 1 [KO:K05665] [EC:7.6.2.3]
100314811  MIR214; eca-miR-214 [KO:K17151]
100051990  BRCA1; breast cancer type 1 susceptibility protein isoform X4 [KO:K10605] [EC:2.3.2.27]
100314855  MIR106B; eca-miR-106b [KO:K17035]
100064022  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
100063240  EFNA4; ephrin-A4 isoform X1 [KO:K05462]
100073202  EFNA5; ephrin-A5 isoform X1 [KO:K05462]
100063307  EFNA1; ephrin-A1 [KO:K05462]
100057186  EFNA3; ephrin-A3 isoform X1 [KO:K05462]
111774429  EFNA2; ephrin-A2 [KO:K05462]
100057478  THBS1; thrombospondin-1 precursor [KO:K16857]
100055918  IGF2BP1; insulin-like growth factor 2 mRNA-binding protein 1 isoform X1 [KO:K17391]
100056593  TRIM71; E3 ubiquitin-protein ligase TRIM71 [KO:K12035] [EC:2.3.2.27]
100314972  MIR34B; eca-miR-34b-5p [KO:K16983]
100314826  MIR34C; eca-miR-34c [KO:K23572]
100314864  MIR9A-2; eca-miR-9a [KO:K16977]
100314814  MIR9A; eca-miR-9a [KO:K16977]
100067894  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X4 [KO:K02580]
100314809  MIR199A; eca-miR-199a-5p [KO:K17118]
100050167  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
791253  PTGS2; prostaglandin G/H synthase 2 precursor [KO:K11987] [EC:1.14.99.1]
100057701  MAPK1; mitogen-activated protein kinase 1 isoform X2 [KO:K04371] [EC:2.7.11.24]
100066173  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
100063318  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
100069215  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
100062549  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
100051866  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
100034114  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
100062953  RPS6KA5; ribosomal protein S6 kinase alpha-5 [KO:K04445] [EC:2.7.11.1]
100062044  TP53; cellular tumor antigen p53 [KO:K04451]
100052084  MDM2; E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:2.3.2.27]
100050113  MDM4; protein Mdm4 isoform X2 [KO:K10127]
100059815  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
100070545  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X3 [KO:K01116] [EC:3.1.4.11]
100055670  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 isoform X2 [KO:K05859] [EC:3.1.4.11]
100314805  MIR101-1; eca-miR-101 [KO:K17129]
100314986  MIR101-2; eca-miR-101 [KO:K17129]
100051110  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
100315058  MIR195; eca-miR-195 [KO:K17029]
100065996  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X2 [KO:K04368] [EC:2.7.12.2]
100063190  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
100053889  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
100066282  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
100063053  SHC1; SHC-transforming protein 1 isoform X2 [KO:K06279]
100055086  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
100314966  MIR129A; eca-miR-129a-5p [KO:K17368]
100314977  MIR129B; eca-miR-129b-5p [KO:K17368]
100055699  SHC4; SHC-transforming protein 4 [KO:K17449]
100070283  PDGFB; platelet-derived growth factor subunit B isoform X1 [KO:K17386]
100071665  PDGFRB; platelet-derived growth factor receptor beta isoform X2 [KO:K05089] [EC:2.7.10.1]
100146270  cyclin-dependent kinase 4 inhibitor B [KO:K06621]
100069192  E2F1; transcription factor E2F1 [KO:K17454]
100057866  E2F2; transcription factor E2F2 isoform X2 [KO:K09389]
100315086  MIR32; eca-miR-32 [KO:K17039]
100064312  BCL2L11; bcl-2-like protein 11 isoform X6 [KO:K16341]
111775348  MARCKS; LOW QUALITY PROTEIN: myristoylated alanine-rich C-kinase substrate [KO:K12561]
100067195  BMPR2; bone morphogenetic protein receptor type-2 [KO:K04671] [EC:2.7.11.30]
100315020  MIR449A; eca-miR-449a [KO:K17377]
100072578  HDAC2; histone deacetylase 2 [KO:K06067] [EC:3.5.1.98]
100070281  HDAC1; histone deacetylase 1 [KO:K06067] [EC:3.5.1.98]
100051290  EZH2; histone-lysine N-methyltransferase EZH2 isoform X1 [KO:K11430] [EC:2.1.1.356]
100069617  GLS; glutaminase kidney isoform, mitochondrial isoform X1 [KO:K01425] [EC:3.5.1.2]
100059765  GLS2; glutaminase liver isoform, mitochondrial isoform X1 [KO:K01425] [EC:3.5.1.2]
100072571  SIRT1; NAD-dependent protein deacetylase sirtuin-1 isoform X2 [KO:K11411] [EC:2.3.1.286]
100049880  WNT3; proto-oncogene Wnt-3 [KO:K00312]
100061145  WNT3A; protein Wnt-3a [KO:K00312]
100314928  MIR331; eca-miR-331 [KO:K17374]
100050887  CDCA5; sororin isoform X10 [KO:K17390]
100064697  KIF23; kinesin-like protein KIF23 isoform X1 [KO:K17387]
100034056  ROCK1; rho-associated protein kinase 1 [KO:K04514] [EC:2.7.11.1]
100053394  PRKCE; protein kinase C epsilon type isoform X1 [KO:K18050] [EC:2.7.11.13]
100050382  SLC45A3; solute carrier family 45 member 3 [KO:K15379]
100056088  VIM; vimentin [KO:K07606]
Reference
PMID:18817506
  Authors
Lee YS, Dutta A
  Title
MicroRNAs in cancer.
  Journal
Annu Rev Pathol 4:199-227 (2009)
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Reference
PMID:21402473
  Authors
Babashah S, Soleimani M
  Title
The oncogenic and tumour suppressive roles of microRNAs in cancer and apoptosis.
  Journal
Eur J Cancer 47:1127-37 (2011)
DOI:10.1016/j.ejca.2011.02.008
Reference
PMID:19630570
  Authors
Garzon R, Calin GA, Croce CM
  Title
MicroRNAs in Cancer.
  Journal
Annu Rev Med 60:167-79 (2009)
DOI:10.1146/annurev.med.59.053006.104707
Reference
PMID:23075324
  Authors
Chen PS, Su JL, Hung MC
  Title
Dysregulation of microRNAs in cancer.
  Journal
J Biomed Sci 19:90 (2012)
DOI:10.1186/1423-0127-19-90
Reference
PMID:22035854
  Authors
Ling H, Zhang W, Calin GA
  Title
Principles of microRNA involvement in human cancers.
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Chin J Cancer 30:739-48 (2011)
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Reference
PMID:22351564
  Authors
Iorio MV, Croce CM
  Title
MicroRNA dysregulation in cancer: diagnostics, monitoring and therapeutics. A comprehensive review.
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EMBO Mol Med 4:143-59 (2012)
DOI:10.1002/emmm.201100209
Reference
PMID:21742789
  Authors
Sayed D, Abdellatif M
  Title
MicroRNAs in development and disease.
  Journal
Physiol Rev 91:827-87 (2011)
DOI:10.1152/physrev.00006.2010
Reference
PMID:22345301
  Authors
Wang Q, Wang S, Wang H, Li P, Ma Z
  Title
MicroRNAs: novel biomarkers for lung cancer diagnosis, prediction and treatment.
  Journal
Exp Biol Med (Maywood) 237:227-35 (2012)
DOI:10.1258/ebm.2011.011192
Reference
PMID:22580099
  Authors
Song JH, Meltzer SJ
  Title
MicroRNAs in pathogenesis, diagnosis, and treatment of gastroesophageal cancers.
  Journal
Gastroenterology 143:35-47.e2 (2012)
DOI:10.1053/j.gastro.2012.05.003
Reference
PMID:23462054
  Authors
Chu Y, Zhu H, Lv L, Zhou Y, Huo J
  Title
MiRNA s in oesophageal squamous cancer.
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Neth J Med 71:69-75 (2013)
Reference
PMID:19773200
  Authors
Kan T, Meltzer SJ
  Title
MicroRNAs in Barrett's esophagus and esophageal adenocarcinoma.
  Journal
Curr Opin Pharmacol 9:727-32 (2009)
DOI:10.1016/j.coph.2009.08.009
Reference
PMID:20128019
  Authors
Smith CM, Watson DI, Michael MZ, Hussey DJ
  Title
MicroRNAs, development of Barrett's esophagus, and progression to esophageal adenocarcinoma.
  Journal
World J Gastroenterol 16:531-7 (2010)
DOI:10.3748/wjg.v16.i5.531
Reference
PMID:23165235
  Authors
Song S, Ajani JA
  Title
The role of microRNAs in cancers of the upper gastrointestinal tract.
  Journal
Nat Rev Gastroenterol Hepatol 10:109-18 (2013)
DOI:10.1038/nrgastro.2012.210
Reference
PMID:21565290
  Authors
Liu WH, Yeh SH, Chen PJ
  Title
Role of microRNAs in hepatitis B virus replication and pathogenesis.
  Journal
Biochim Biophys Acta 1809:678-85 (2011)
DOI:10.1016/j.bbagrm.2011.04.008
Reference
PMID:23091478
  Authors
Hrasovec S, Glavac D
  Title
MicroRNAs as Novel Biomarkers in Colorectal Cancer.
  Journal
Front Genet 3:180 (2012)
DOI:10.3389/fgene.2012.00180
Reference
PMID:22926415
  Authors
Liu H
  Title
MicroRNAs in breast cancer initiation and progression.
  Journal
Cell Mol Life Sci 69:3587-99 (2012)
DOI:10.1007/s00018-012-1128-9
Reference
PMID:20345848
  Authors
Li SD, Zhang JR, Wang YQ, Wan XP
  Title
The role of microRNAs in ovarian cancer initiation and progression.
  Journal
J Cell Mol Med 14:2240-9 (2010)
DOI:10.1111/j.1582-4934.2010.01058.x
Reference
PMID:23316212
  Authors
Zabolotneva AA, Zhavoronkov A, Garazha AV, Roumiantsev SA, Buzdin AA
  Title
Characteristic patterns of microRNA expression in human bladder cancer.
  Journal
Front Genet 3:310 (2012)
DOI:10.3389/fgene.2012.00310
Reference
PMID:20221895
  Authors
Saini S, Majid S, Dahiya R
  Title
Diet, microRNAs and prostate cancer.
  Journal
Pharm Res 27:1014-26 (2010)
DOI:10.1007/s11095-010-0086-x
Related
pathway
ecb05210  Colorectal cancer
ecb05214  Glioma
ecb05215  Prostate cancer
ecb05219  Bladder cancer
ecb05222  Small cell lung cancer
ecb05223  Non-small cell lung cancer
KO pathway
ko05206   
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