KEGG   PATHWAY: gvr05170
Entry
gvr05170                    Pathway                                
Name
Human immunodeficiency virus 1 infection - Galeopterus variegatus (Sunda flying lemur)
Description
Human immunodeficiency virus type 1 (HIV-1) , the causative agent of AIDS (acquired immunodeficiency syndrome), is a lentivirus belonging to the Retroviridae family. The primary cell surface receptor for HIV-1, the CD4 protein, and the co-receptor for HIV-1, either CCR5 or CXCR4, are found on macrophages and T lymphocytes. At the earliest step, sequential binding of virus envelope (Env) glycoprotein gp120 to CD4 and the co-receptor CCR5 or CXCR4 facilitates HIV-1 entry and has the potential to trigger critical signaling that may favor viral replication. At advanced stages of the disease, HIV-1 infection results in dramatic induction of T-cell (CD4+ T and CD8+ T cell) apoptosis both in infected and uninfected bystander T cells, a hallmark of HIV-1 pathogenesis. On the contrary, macrophages are resistant to the cytopathic effect of HIV-1 and produce virus for longer periods of time.
Class
Human Diseases; Infectious disease: viral
Pathway map
gvr05170  Human immunodeficiency virus 1 infection
gvr05170

Organism
Galeopterus variegatus (Sunda flying lemur) [GN:gvr]
Gene
103586411  CD4; T-cell surface glycoprotein CD4 [KO:K06454]
103590184  FBXW11; F-box/WD repeat-containing protein 11 isoform X1 [KO:K03362]
103598080  BTRC; F-box/WD repeat-containing protein 1A isoform X1 [KO:K03362]
103583634  S-phase kinase-associated protein 1-like [KO:K03094]
103605443  LOW QUALITY PROTEIN: S-phase kinase-associated protein 1-like [KO:K03094]
103592397  SKP1; S-phase kinase-associated protein 1 [KO:K03094]
103592393  CUL1; cullin-1 [KO:K03347]
103585666  RBX1; E3 ubiquitin-protein ligase RBX1 [KO:K03868] [EC:2.3.2.32]
103591817  CXCR4; C-X-C chemokine receptor type 4 [KO:K04189]
103598166  CCR5; C-C chemokine receptor type 5 [KO:K04180]
103588331  GNAI1; guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
103585560  GNAI3; guanine nucleotide-binding protein G(k) subunit alpha [KO:K04630]
103593713  GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2 isoform X1 [KO:K04630]
103590972  GNAO1; guanine nucleotide-binding protein G(o) subunit alpha isoform X1 [KO:K04534]
103586572  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
103586784  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
103587883  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
103585463  PIK3R3; LOW QUALITY PROTEIN: phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
103593683  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
103608454  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
103587023  PTK2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
103595200  PTK2B; protein-tyrosine kinase 2-beta [KO:K05871] [EC:2.7.10.2]
103599798  PXN; paxillin [KO:K05760]
103592708  CRKL; crk-like protein [KO:K04438]
103608491  CRK; adapter molecule crk isoform X1 [KO:K04438]
103596384  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
103590279  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
103598325  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
103605698  RAC-gamma serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
103601062  MTOR; serine/threonine-protein kinase mTOR isoform X1 [KO:K07203] [EC:2.7.11.1]
103595380  RPS6KB1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
103589982  RPS6KB2; ribosomal protein S6 kinase beta-2 isoform X1 [KO:K04688] [EC:2.7.11.1]
103597025  NFKB1; nuclear factor NF-kappa-B p105 subunit [KO:K02580]
103595334  RELA; transcription factor p65 [KO:K04735]
103605891  FOS; proto-oncogene c-Fos [KO:K04379]
103592390  JUN; transcription factor AP-1 [KO:K04448]
103586204  BAD; bcl2 antagonist of cell death [KO:K02158]
103610513  HRAS; GTPase HRas isoform X1 [KO:K02833]
103599501  KRAS; GTPase KRas [KO:K07827]
103589329  NRAS; GTPase NRas [KO:K07828]
103590618  RAF1; RAF proto-oncogene serine/threonine-protein kinase [KO:K04366] [EC:2.7.11.1]
103596129  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
103600170  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369] [EC:2.7.12.2]
103592192  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
103600324  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
103587098  GNAQ; guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
103604359  guanine nucleotide-binding protein subunit alpha-11 [KO:K04635]
103606318  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116] [EC:3.1.4.11]
103591521  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
103598637  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 [KO:K04958]
103597698  inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
103601309  calmodulin-like protein 3 [KO:K02183]
103601310  CALML5; calmodulin-like protein 5 [KO:K02183]
103588449  CALM1; calmodulin [KO:K02183]
103601992  calmodulin-like [KO:K02183]
103591330  CALML4; calmodulin-like protein 4 isoform X1 [KO:K02183]
103592983  CALM3; LOW QUALITY PROTEIN: calmodulin [KO:K02183]
103599723  CALML6; LOW QUALITY PROTEIN: calmodulin-like protein 6 [KO:K02183]
103591114  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform [KO:K04348] [EC:3.1.3.16]
103598106  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
103598210  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
103604521  PPP3R2; calcineurin subunit B type 2 isoform X1 [KO:K06268]
103585050  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 [KO:K04446]
103598251  NFATC2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332]
103586032  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 [KO:K17333]
103590142  NFATC4; nuclear factor of activated T-cells, cytoplasmic 4 isoform X1 [KO:K17334]
103599847  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
103592574  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
103583388  protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
103599669  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
103599715  GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
103596930  GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
103586407  GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 isoform X1 [KO:K07825]
103586779  GNB4; guanine nucleotide-binding protein subunit beta-4 [KO:K04538]
103601724  GNB5; guanine nucleotide-binding protein subunit beta-5 [KO:K04539]
103591088  GNG3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
103592984  GNG8; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 isoform X1 [KO:K04544]
103589599  GNG11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
103588774  GNG13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547]
103589588  GNGT1; guanine nucleotide-binding protein G(T) subunit gamma-T1 isoform X1 [KO:K04548]
103594082  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
103606391  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
103593345  RAC3; ras-related C3 botulinum toxin substrate 3 [KO:K07861]
103600263  serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
103586253  PAK2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
103594793  PAK3; serine/threonine-protein kinase PAK 3 isoform X1 [KO:K05733] [EC:2.7.11.1]
103599260  PAK4; serine/threonine-protein kinase PAK 4 isoform X1 [KO:K05734] [EC:2.7.11.1]
103603905  PAK7; serine/threonine-protein kinase PAK 7 [KO:K05736] [EC:2.7.11.1]
103591302  PAK6; serine/threonine-protein kinase PAK 6 [KO:K05735] [EC:2.7.11.1]
103597746  LIMK1; LIM domain kinase 1 isoform X1 [KO:K05743] [EC:2.7.11.1]
103605064  LIMK2; LIM domain kinase 2 [KO:K05744] [EC:2.7.11.1]
103591327  CFL2; cofilin-2 [KO:K05765]
103599224  CFL1; cofilin-1 [KO:K05765]
103592383  TNF; tumor necrosis factor [KO:K03156]
103605089  TNFRSF1B; tumor necrosis factor receptor superfamily member 1B [KO:K05141]
103594063  BCL2L1; bcl-2-like protein 1 isoform X1 [KO:K04570]
103602848  TLR4; toll-like receptor 4 isoform X1 [KO:K10160]
103602129  MYD88; myeloid differentiation primary response protein MyD88 [KO:K04729]
103595699  IRAK4; interleukin-1 receptor-associated kinase 4 [KO:K04733] [EC:2.7.11.1]
103595100  IRAK1; interleukin-1 receptor-associated kinase 1 [KO:K04730] [EC:2.7.11.1]
103601167  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
103599298  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 [KO:K04403]
103593058  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 [KO:K04404]
103599396  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
103588798  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
103589266  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
103604367  IKBKG; NF-kappa-B essential modulator [KO:K07210]
103591436  NFKBIA; LOW QUALITY PROTEIN: NF-kappa-B inhibitor alpha [KO:K04734]
103598039  interferon alpha-4-like [KO:K05414]
103598040  interferon alpha-10-like [KO:K05414]
103598043  interferon alpha-10-like [KO:K05414]
103598044  interferon alpha-3-like [KO:K05414]
103609847  interferon beta-like [KO:K05415]
103609850  interferon beta-like [KO:K05415]
103584029  interferon beta-like [KO:K05415]
103607428  MAPK13; mitogen-activated protein kinase 13 isoform X1 [KO:K04441] [EC:2.7.11.24]
103607442  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
103587477  MAPK12; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
103587478  MAPK11; mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
103582610  mitogen-activated protein kinase 9-like isoform X1 [KO:K04440] [EC:2.7.11.24]
103603521  mitogen-activated protein kinase 10 [KO:K04440] [EC:2.7.11.24]
103585627  MAPK8; mitogen-activated protein kinase 8 [KO:K04440] [EC:2.7.11.24]
103606635  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
103595481  MB21D1; cyclic GMP-AMP synthase [KO:K17834] [EC:2.7.7.86]
103584100  stimulator of interferon genes protein-like [KO:K12654]
103587190  TMEM173; stimulator of interferon genes protein [KO:K12654]
103590122  TBK1; serine/threonine-protein kinase TBK1 [KO:K05410] [EC:2.7.11.10]
103592597  IRF3; interferon regulatory factor 3 [KO:K05411]
103581391  DNA dC->dU-editing enzyme APOBEC-3G-like [KO:K18750] [EC:3.5.4.-]
103581392  DNA dC->dU-editing enzyme APOBEC-3A-like [KO:K18750] [EC:3.5.4.-]
103582173  DNA dC->dU-editing enzyme APOBEC-3C-like [KO:K18750] [EC:3.5.4.-]
103583284  DNA dC->dU-editing enzyme APOBEC-3G-like [KO:K18750] [EC:3.5.4.-]
103583285  DNA dC->dU-editing enzyme APOBEC-3G-like [KO:K18750] [EC:3.5.4.-]
103584151  DNA dC->dU-editing enzyme APOBEC-3G-like [KO:K18750] [EC:3.5.4.-]
103600466  APOBEC3H; DNA dC->dU-editing enzyme APOBEC-3H [KO:K18750] [EC:3.5.4.-]
103592577  SAMHD1; deoxynucleoside triphosphate triphosphohydrolase SAMHD1 isoform X1 [KO:K22544] [EC:3.1.5.-]
103609157  tripartite motif-containing protein 5-like [KO:K10648] [EC:2.3.2.27]
103581138  LOW QUALITY PROTEIN: tripartite motif-containing protein 5-like [KO:K10648] [EC:2.3.2.27]
103605871  LOW QUALITY PROTEIN: tripartite motif-containing protein 5-like [KO:K10648] [EC:2.3.2.27]
103596833  BST2; bone marrow stromal antigen 2 [KO:K06731]
103605365  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
103604452  RIPK1; receptor-interacting serine/threonine-protein kinase 1 isoform X1 [KO:K02861] [EC:2.7.11.1]
103602860  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein isoform X1 [KO:K03171]
103599657  TRAF5; TNF receptor-associated factor 5 [KO:K09849]
103610047  TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
103610988  TRAF2; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
103599172  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 [KO:K04432] [EC:2.7.12.2]
103583282  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 [KO:K04433] [EC:2.7.12.2]
103596394  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
103605950  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
103607184  FAS; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
103605154  FADD; FAS-associated death domain protein [KO:K02373]
103597790  CASP8; caspase-8 [KO:K04398] [EC:3.4.22.61]
103594881  BID; BH3-interacting domain death agonist [KO:K04726]
103587762  BAX; apoptosis regulator BAX isoform X1 [KO:K02159]
103599851  BAK1; bcl-2 homologous antagonist/killer [KO:K14021]
103606686  BCL2; apoptosis regulator Bcl-2 [KO:K02161]
103610678  cytochrome c, somatic [KO:K08738]
103590229  cytochrome c, somatic-like [KO:K08738]
103590595  CASP9; caspase-9 [KO:K04399] [EC:3.4.22.62]
103589530  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
103582933  uncharacterized protein LOC103582933 [KO:K10784]
103604227  uncharacterized protein LOC103604227 [KO:K10784]
103605353  uncharacterized protein LOC103605353 [KO:K10785]
103592268  CD3E; T-cell surface glycoprotein CD3 epsilon chain [KO:K06451]
103592270  CD3G; T-cell surface glycoprotein CD3 gamma chain [KO:K06452]
103592269  CD3D; T-cell surface glycoprotein CD3 delta chain isoform X1 [KO:K06450]
103601908  CD247; T-cell surface glycoprotein CD3 zeta chain [KO:K06453]
103608009  TAP1; antigen peptide transporter 1 [KO:K05653] [EC:7.4.2.14]
103608007  TAP2; antigen peptide transporter 2 [KO:K05654] [EC:7.4.2.14]
103597948  TAPBP; tapasin isoform X1 [KO:K08058]
103598543  PDIA3; protein disulfide-isomerase A3 [KO:K08056] [EC:5.3.4.1]
103596637  calreticulin-like [KO:K08057]
103585635  CALR; calreticulin [KO:K08057]
103609219  LOW QUALITY PROTEIN: HLA class I histocompatibility antigen, A-11 alpha chain-like [KO:K06751]
103610244  LOW QUALITY PROTEIN: saoe class I histocompatibility antigen, A alpha chain-like [KO:K06751]
103602353  patr class I histocompatibility antigen, A-126 alpha chain-like [KO:K06751]
103610772  patr class I histocompatibility antigen, A-126 alpha chain-like [KO:K06751]
103606064  patr class I histocompatibility antigen, A-2 alpha chain [KO:K06751]
103586434  LOW QUALITY PROTEIN: saoe class I histocompatibility antigen, A alpha chain-like [KO:K06751]
103592560  HLA class I histocompatibility antigen, alpha chain E-like [KO:K06751]
103588197  AP1B1; AP-1 complex subunit beta-1 [KO:K12392]
103597209  AP1G1; AP-1 complex subunit gamma-1 isoform X1 [KO:K12391]
103585589  AP1G2; AP-1 complex subunit gamma-like 2 isoform X1 [KO:K12391]
103581343  AP1M2; AP-1 complex subunit mu-2 [KO:K12393]
103603068  AP1M1; AP-1 complex subunit mu-1 isoform X1 [KO:K12393]
103604902  AP1S1; AP-1 complex subunit sigma-1A [KO:K12394]
103599114  AP1S2; AP-1 complex subunit sigma-2 isoform X1 [KO:K12394]
103594497  AP1S3; AP-1 complex subunit sigma-3 [KO:K12395]
103601963  B2M; beta-2-microglobulin [KO:K08055]
103585383  TCEB2; transcription elongation factor B polypeptide 2 [KO:K03873]
103595473  TCEB1; transcription elongation factor B polypeptide 1 [KO:K03872]
103587032  transcription elongation factor B polypeptide 1-like [KO:K03872]
103597514  CUL5; cullin-5 [KO:K10612]
103602290  RNF7; RING-box protein 2 [KO:K10611]
103583982  RING-box protein 2 [KO:K10611]
103586789  VPRBP; protein VPRBP isoform X1 [KO:K11789] [EC:2.7.11.1]
103592901  DDB1; DNA damage-binding protein 1 [KO:K10610]
103602915  CUL4B; cullin-4B isoform X1 [KO:K10609]
103590640  CUL4A; cullin-4A [KO:K10609]
103597510  ATM; serine-protein kinase ATM [KO:K04728] [EC:2.7.11.1]
103601244  serine/threonine-protein kinase ATR [KO:K06640] [EC:2.7.11.1]
103608913  CHEK1; serine/threonine-protein kinase Chk1 [KO:K02216] [EC:2.7.11.1]
103583154  serine/threonine-protein kinase Chk1-like [KO:K02216] [EC:2.7.11.1]
103590544  CDC25C; M-phase inducer phosphatase 3 [KO:K05867] [EC:3.1.3.48]
103585870  WEE2; wee1-like protein kinase 2 [KO:K06632] [EC:2.7.11.1]
103593186  WEE1; wee1-like protein kinase [KO:K06632] [EC:2.7.11.1]
103602744  CCNB1; G2/mitotic-specific cyclin-B1 [KO:K05868]
103602482  LOW QUALITY PROTEIN: G2/mitotic-specific cyclin-B2-like [KO:K21770]
103593976  CCNB2; G2/mitotic-specific cyclin-B2 [KO:K21770]
103608978  CCNB3; G2/mitotic-specific cyclin-B3 [KO:K21771]
103585615  CDK1; cyclin-dependent kinase 1 [KO:K02087] [EC:2.7.11.22 2.7.11.23]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C01245  D-myo-Inositol 1,4,5-trisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C20640  Cyclic GMP-AMP
Reference
PMID:22749173
  Authors
Evans VA, Khoury G, Saleh S, Cameron PU, Lewin SR
  Title
HIV persistence: chemokines and their signalling pathways.
  Journal
Cytokine Growth Factor Rev 23:151-7 (2012)
DOI:10.1016/j.cytogfr.2012.05.002
Reference
PMID:23806647
  Authors
Abbas W, Herbein G
  Title
Plasma membrane signaling in HIV-1 infection.
  Journal
Biochim Biophys Acta 1838:1132-42 (2014)
DOI:10.1016/j.bbamem.2013.06.020
Reference
PMID:20041213
  Authors
Wu Y, Yoder A
  Title
Chemokine coreceptor signaling in HIV-1 infection and pathogenesis.
  Journal
PLoS Pathog 5:e1000520 (2009)
DOI:10.1371/journal.ppat.1000520
Reference
PMID:22085380
  Authors
Choi WT, Duggineni S, Xu Y, Huang Z, An J
  Title
Drug discovery research targeting the CXC chemokine receptor 4 (CXCR4).
  Journal
J Med Chem 55:977-94 (2012)
DOI:10.1021/jm200568c
Reference
PMID:21321123
  Authors
Vorster PJ, Guo J, Yoder A, Wang W, Zheng Y, Xu X, Yu D, Spear M, Wu Y
  Title
LIM kinase 1 modulates cortical actin and CXCR4 cycling and is activated by HIV-1 to initiate viral infection.
  Journal
J Biol Chem 286:12554-64 (2011)
DOI:10.1074/jbc.M110.182238
Reference
PMID:15817946
  Authors
Das SR, Jameel S
  Title
Biology of the HIV Nef protein.
  Journal
Indian J Med Res 121:315-32 (2005)
Reference
PMID:24822052
  Authors
Roy N, Pacini G, Berlioz-Torrent C, Janvier K
  Title
Mechanisms underlying HIV-1 Vpu-mediated viral egress.
  Journal
Front Microbiol 5:177 (2014)
DOI:10.3389/fmicb.2014.00177
Reference
PMID:22090097
  Authors
Magadan JG, Bonifacino JS
  Title
Transmembrane domain determinants of CD4 Downregulation by HIV-1 Vpu.
  Journal
J Virol 86:757-72 (2012)
DOI:10.1128/JVI.05933-11
Reference
PMID:26056579
  Authors
Kumar A, Herbein G
  Title
The macrophage: a therapeutic target in HIV-1 infection.
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Related
pathway
gvr03050  Proteasome
gvr04010  MAPK signaling pathway
gvr04020  Calcium signaling pathway
gvr04064  NF-kappa B signaling pathway
gvr04110  Cell cycle
gvr04141  Protein processing in endoplasmic reticulum
gvr04142  Lysosome
gvr04150  mTOR signaling pathway
gvr04151  PI3K-Akt signaling pathway
gvr04210  Apoptosis
gvr04612  Antigen processing and presentation
gvr04620  Toll-like receptor signaling pathway
gvr04623  Cytosolic DNA-sensing pathway
gvr04668  TNF signaling pathway
gvr04810  Regulation of actin cytoskeleton
KO pathway
ko05170   
LinkDB

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