KEGG   PATHWAY: mbez05010
Entry
mbez05010                   Pathway                                
Name
Alzheimer disease - Moschus berezovskii (Chinese forest musk deer)
Description
Alzheimer disease (AD) is a chronic disorder that slowly destroys neurons and causes serious cognitive disability. AD is associated with senile plaques and neurofibrillary tangles (NFTs). Amyloid-beta (Abeta), a major component of senile plaques, has various pathological effects on cell and organelle function. To date genetic studies have revealed four genes that may be linked to autosomal dominant or familial early onset AD (FAD). These four genes include: amyloid precursor protein (APP), presenilin 1 (PS1), presenilin 2 (PS2) and apolipoprotein E (ApoE). All mutations associated with APP and PS proteins can lead to an increase in the production of Abeta peptides, specfically the more amyloidogenic form, Abeta42. It was proposed that Abeta form Ca2+ permeable pores and bind to and modulate multiple synaptic proteins, including NMDAR, mGluR5 and VGCC, leading to the overfilling of neurons with calcium ions. Consequently, cellular Ca2+ disruptions will lead to neuronal apoptosis, autophagy deficits, mitochondrial abnormality, defective neurotransmission, impaired synaptic plasticity and neurodegeneration in AD. FAD-linked PS1 mutation downregulates the unfolded protein response and leads to vulnerability to ER stress.
Class
Human Diseases; Neurodegenerative disease
Pathway map
mbez05010  Alzheimer disease
mbez05010

Organism
Moschus berezovskii (Chinese forest musk deer) [GN:mbez]
Gene
129563558  ADAM10; disintegrin and metalloproteinase domain-containing protein 10 isoform X1 [KO:K06704] [EC:3.4.24.81]
129539087  ADAM17; disintegrin and metalloproteinase domain-containing protein 17 [KO:K06059] [EC:3.4.24.86]
129553058  APP; amyloid-beta precursor protein isoform X1 [KO:K04520]
129547038  NAE1; NEDD8-activating enzyme E1 regulatory subunit [KO:K04532]
129554589  APBB1; amyloid beta precursor protein binding family B member 1 [KO:K04529]
129535686  GAPDH; glyceraldehyde-3-phosphate dehydrogenase [KO:K00134] [EC:1.2.1.12]
129550004  glyceraldehyde-3-phosphate dehydrogenase-like [KO:K00134] [EC:1.2.1.12]
129554366  BACE1; beta-secretase 1 [KO:K04521] [EC:3.4.23.46]
129547972  BACE2; beta-secretase 2 [KO:K07747] [EC:3.4.23.45]
129548837  RTN3; reticulon-3 [KO:K20723]
129539921  RTN4; reticulon-4 [KO:K20720]
129546140  PSENEN; gamma-secretase subunit PEN-2 [KO:K06170]
129562460  PSEN1; presenilin-1 isoform X1 [KO:K04505] [EC:3.4.23.-]
129551626  PSEN2; presenilin-2 isoform X1 [KO:K04522] [EC:3.4.23.-]
129540516  NCSTN; nicastrin [KO:K06171]
129563517  APH1B; gamma-secretase subunit APH-1B [KO:K06172]
129541309  APH1A; gamma-secretase subunit APH-1A [KO:K06172]
129555541  IDE; insulin-degrading enzyme isoform X1 [KO:K01408] [EC:3.4.24.56]
129551925  MME; neprilysin [KO:K01389] [EC:3.4.24.11]
129544523  MAPT; microtubule-associated protein tau isoform X1 [KO:K04380]
7872555  ND1; NADH dehydrogenase subunit 1 [KO:K03878] [EC:7.1.1.2]
7872543  ND2; NADH dehydrogenase subunit 2 [KO:K03879] [EC:7.1.1.2]
7872549  ND3; NADH dehydrogenase subunit 3 [KO:K03880] [EC:7.1.1.2]
7872551  ND4; NADH dehydrogenase subunit 4 [KO:K03881] [EC:7.1.1.2]
7872550  ND4L; NADH dehydrogenase subunit 4L [KO:K03882] [EC:7.1.1.2]
7872552  ND5; NADH dehydrogenase subunit 5 [KO:K03883] [EC:7.1.1.2]
7872553  ND6; NADH dehydrogenase subunit 6 [KO:K03884] [EC:7.1.1.2]
129548685  NDUFV1; NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial [KO:K03942] [EC:7.1.1.2]
129549785  NDUFV2; NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial [KO:K03943] [EC:7.1.1.2]
129548146  NDUFV3; NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial isoform X1 [KO:K03944]
129559361  NDUFA2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 [KO:K03946]
129546048  NDUFA3; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 isoform X1 [KO:K03947]
129536721  NDUFA4L2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 [KO:K03948]
129536909  cytochrome c oxidase subunit NDUFA4-like [KO:K03948]
129552258  NDUFA4; cytochrome c oxidase subunit NDUFA4 [KO:K03948]
129557319  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5-like [KO:K03949]
129552607  NDUFA5; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 [KO:K03949]
129536257  NDUFA6; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 [KO:K03950]
129558629  NDUFA7; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 [KO:K03951]
129539677  NDUFA8; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 [KO:K03952]
129536388  NDUFA9; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial isoform X1 [KO:K03953]
129540843  NDUFA10; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial [KO:K03954]
129545460  NDUFAB1; acyl carrier protein, mitochondrial [KO:K03955]
129559417  NDUFA11; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 [KO:K03956]
129536626  NDUFA12; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 [KO:K11352]
129559529  NDUFA13; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 [KO:K11353]
129552713  NDUFB2; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial [KO:K03958]
129538372  NDUFB3; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 [KO:K03959]
129562206  NDUFB4; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 [KO:K03960]
129557517  NDUFB6; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 [KO:K03962]
129558310  NDUFB7; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 [KO:K03963]
129563161  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial-like [KO:K03964]
129563333  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial-like [KO:K03964]
129538417  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial-like [KO:K03964]
129555441  NDUFB8; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial [KO:K03964]
129539436  NDUFB9; LOW QUALITY PROTEIN: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 [KO:K03965]
129545250  NDUFB10; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 [KO:K03966]
129564391  NDUFB11; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial [KO:K11351]
129537781  NDUFS1; NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial [KO:K03934] [EC:7.1.1.2]
129541195  NDUFS2; NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial [KO:K03935] [EC:7.1.1.2]
129554830  NDUFS3; NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial [KO:K03936] [EC:7.1.1.2]
129553266  NDUFS4; NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial [KO:K03937]
129541431  NDUFS5; NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 [KO:K03938]
129553392  NDUFS6; NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial [KO:K03939]
129558789  NDUFS7; NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial isoform X1 [KO:K03940] [EC:7.1.1.2]
129548680  NDUFS8; NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial isoform X1 [KO:K03941] [EC:7.1.1.2]
129542435  NDUFC1; NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial [KO:K03967]
129549039  NDUFC2; NADH dehydrogenase [ubiquinone] 1 subunit C2 [KO:K03968]
129553417  SDHA; succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial [KO:K00234] [EC:1.3.5.1]
129537568  SDHB; succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial [KO:K00235] [EC:1.3.5.1]
129540820  SDHC; succinate dehydrogenase cytochrome b560 subunit, mitochondrial [KO:K00236]
129551518  succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial-like [KO:K00237]
129554330  SDHD; succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial [KO:K00237]
129547289  cytochrome b-c1 complex subunit Rieske, mitochondrial [KO:K00411] [EC:7.1.1.8]
7872554  CYTB; cytochrome b [KO:K00412]
129560239  cytochrome c1, heme protein, mitochondrial [KO:K00413]
129547809  cytochrome b-c1 complex subunit 1, mitochondrial [KO:K00414]
129545439  cytochrome b-c1 complex subunit 2, mitochondrial [KO:K00415]
129541300  cytochrome b-c1 complex subunit 6, mitochondrial [KO:K00416]
129538687  cytochrome b-c1 complex subunit 7-like [KO:K00417]
129559837  cytochrome b-c1 complex subunit 7 [KO:K00417]
129538008  cytochrome b-c1 complex subunit 8-like [KO:K00418]
129559505  cytochrome b-c1 complex subunit 8 [KO:K00418]
7872548  COX3; cytochrome c oxidase subunit III [KO:K02262]
7872544  COX1; cytochrome c oxidase subunit I [KO:K02256] [EC:7.1.1.9]
7872545  COX2; cytochrome c oxidase subunit II [KO:K02261]
129547198  cytochrome c oxidase subunit 4 isoform 1, mitochondrial [KO:K02263]
129562077  cytochrome c oxidase subunit 4 isoform 2, mitochondrial [KO:K02263]
129550450  cytochrome c oxidase subunit 5A, mitochondrial [KO:K02264]
129539072  cytochrome c oxidase subunit 5A, mitochondrial-like [KO:K02264]
129539786  cytochrome c oxidase subunit 5B, mitochondrial [KO:K02265]
129545568  cytochrome c oxidase subunit 6A2, mitochondrial [KO:K02266]
129542288  cytochrome c oxidase subunit 6A1, mitochondrial [KO:K02266]
129546050  cytochrome c oxidase subunit 6B2 [KO:K02267]
129546145  cytochrome c oxidase subunit 6B1 [KO:K02267]
129539783  cytochrome c oxidase subunit 6B1-like [KO:K02267]
129559906  cytochrome c oxidase subunit 6C [KO:K02268]
129537105  cytochrome c oxidase subunit 7A-related protein, mitochondrial [KO:K02270]
129546136  cytochrome c oxidase subunit 7A1, mitochondrial [KO:K02270]
129560985  cytochrome c oxidase subunit 7A2, mitochondrial [KO:K02270]
129534867  cytochrome c oxidase subunit 7B, mitochondrial [KO:K02271]
129550158  cytochrome c oxidase subunit 8C, mitochondrial [KO:K02273]
129549821  ATP5F1A; ATP synthase subunit alpha, mitochondrial [KO:K02132]
129535664  ATP5F1B; ATP synthase subunit beta, mitochondrial [KO:K02133] [EC:7.1.2.2]
129549267  LOW QUALITY PROTEIN: ATP synthase subunit beta, mitochondrial-like [KO:K02133] [EC:7.1.2.2]
129556910  ATP5F1C; ATP synthase subunit gamma, mitochondrial isoform X1 [KO:K02136]
129558473  ATP5F1D; ATP synthase subunit delta, mitochondrial [KO:K02134]
7872547  ATP6; ATP synthase F0 subunit 6 [KO:K02126]
129536251  LOW QUALITY PROTEIN: ATP synthase F(0) complex subunit B1, mitochondrial-like [KO:K02127]
129541042  ATP5PB; ATP synthase F(0) complex subunit B1, mitochondrial [KO:K02127]
129536222  ATP5MC2; ATP synthase F(0) complex subunit C2, mitochondrial [KO:K02128]
129544287  ATP5MC1; ATP synthase F(0) complex subunit C1, mitochondrial [KO:K02128]
129538226  ATP5MC3; ATP synthase F(0) complex subunit C3, mitochondrial [KO:K02128]
129544741  ATP5PD; ATP synthase subunit d, mitochondrial [KO:K02138]
129545120  ATP synthase subunit d, mitochondrial-like [KO:K02138]
129548151  ATP synthase subunit d, mitochondrial-like [KO:K02138]
129552488  ATP5PO; ATP synthase subunit O, mitochondrial [KO:K02137]
7872546  ATP8; ATP synthase F0 subunit 8 [KO:K02125]
129564227  HSD17B10; 3-hydroxyacyl-CoA dehydrogenase type-2 [KO:K08683] [EC:1.1.1.35 1.1.1.178]
129557628  peptidyl-prolyl cis-trans isomerase D-like [KO:K05864] [EC:5.2.1.8]
129542227  PPID; peptidyl-prolyl cis-trans isomerase D [KO:K05864] [EC:5.2.1.8]
129558217  VDAC1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
129555687  VDAC2; voltage-dependent anion-selective channel protein 2 [KO:K15040]
129549434  VDAC3; voltage-dependent anion-selective channel protein 3 [KO:K15041]
129560157  voltage-dependent anion-selective channel protein 3-like [KO:K15041]
129562882  voltage-dependent anion-selective channel protein 3-like [KO:K15041]
129542617  SLC25A31; ADP/ATP translocase 4 [KO:K05863]
129549309  SLC25A4; ADP/ATP translocase 1 [KO:K05863]
129564629  SLC25A6; ADP/ATP translocase 3 [KO:K05863]
129535024  SLC25A5; ADP/ATP translocase 2 [KO:K05863]
129555671  PPIF; peptidyl-prolyl cis-trans isomerase F, mitochondrial [KO:K09565] [EC:5.2.1.8]
129556869  LPL; lipoprotein lipase [KO:K01059] [EC:3.1.1.34]
129546697  APOE; apolipoprotein E [KO:K04524]
129536418  LRP1; prolow-density lipoprotein receptor-related protein 1 isoform X1 [KO:K04550]
129555563  FAS; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
129535684  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
129548659  FADD; FAS-associated death domain protein [KO:K02373]
129538041  CASP8; caspase-8 [KO:K04398] [EC:3.4.22.61]
129537261  BID; BH3-interacting domain death agonist isoform X1 [KO:K04726]
129562982  CALML4; LOW QUALITY PROTEIN: calmodulin-like protein 4 [KO:K02183]
129563274  calmodulin-1-like [KO:K02183]
129563997  calmodulin-like [KO:K02183]
129564337  calmodulin-1-like [KO:K02183]
129550549  calmodulin-1-like [KO:K02183]
129550970  CALML6; LOW QUALITY PROTEIN: calmodulin-like protein 6 [KO:K02183]
129551800  calmodulin-1-like [KO:K02183]
129539293  CALM2; calmodulin-2 isoform X1 [KO:K02183]
129546635  CALM3; calmodulin-3 [KO:K02183]
129554732  uncharacterized protein LOC129554732 [KO:K02183]
129555444  calmodulin-like [KO:K02183]
129562351  calmodulin-1-like [KO:K02183]
129562550  CALM1; calmodulin-1 isoform X1 [KO:K02183]
129556888  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
129562133  PPP3CA; protein phosphatase 3 catalytic subunit alpha isoform X1 [KO:K04348] [EC:3.1.3.16]
129555711  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
129539040  PPP3R1; calcineurin subunit B type 1 [KO:K06268]
129548816  BAD; bcl2-associated agonist of cell death [KO:K02158]
129536239  cytochrome c-like [KO:K08738]
129538389  cytochrome c 2 [KO:K08738]
129552526  cytochrome c [KO:K08738]
129535887  APAF1; apoptotic protease-activating factor 1 isoform X1 [KO:K02084]
129551377  CASP9; caspase-9 [KO:K04399] [EC:3.4.22.62]
129549305  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
129548449  CHRM1; muscarinic acetylcholine receptor M1 [KO:K04129]
129555841  CHRM3; muscarinic acetylcholine receptor M3 isoform X1 [KO:K04131]
129563413  muscarinic acetylcholine receptor M5-like [KO:K04133]
129562455  LOW QUALITY PROTEIN: muscarinic acetylcholine receptor M5-like [KO:K04133]
129549079  GRM5; metabotropic glutamate receptor 5 [KO:K04604]
129556766  GNAQ; guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
129548814  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform X1 [KO:K05858] [EC:3.1.4.11]
129563187  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11]
129556526  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
129556560  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
129539066  GRIN1; glutamate receptor ionotropic, NMDA 1 [KO:K05208]
129545368  GRIN2A; glutamate receptor ionotropic, NMDA 2A [KO:K05209]
129536255  GRIN2B; glutamate receptor ionotropic, NMDA 2B [KO:K05210]
129538079  GRIN2C; glutamate receptor ionotropic, NMDA 2C isoform X1 [KO:K05211]
129546598  GRIN2D; glutamate receptor ionotropic, NMDA 2D [KO:K05212]
129535727  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C [KO:K04850]
129547932  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
129564275  CACNA1F; voltage-dependent L-type calcium channel subunit alpha-1F [KO:K04853]
129551192  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
129550392  CHRNA7; neuronal acetylcholine receptor subunit alpha-7 [KO:K04809]
129555725  MCU; calcium uniporter protein, mitochondrial isoform X1 [KO:K20858]
129542485  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
129545501  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
129562454  RYR3; ryanodine receptor 3 isoform X1 [KO:K04963]
129548039  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 [KO:K04958]
129536224  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 isoform X1 [KO:K04959]
129543844  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 isoform X1 [KO:K04960]
129542629  ATP2A2; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 isoform X1 [KO:K05853] [EC:7.2.2.10]
129545483  ATP2A1; sarcoplasmic/endoplasmic reticulum calcium ATPase 1 [KO:K05853] [EC:7.2.2.10]
129541748  ATP2A3; sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform X1 [KO:K05853] [EC:7.2.2.10]
129540459  ATF6; cyclic AMP-dependent transcription factor ATF-6 alpha [KO:K09054]
129542397  XBP1; LOW QUALITY PROTEIN: X-box-binding protein 1 [KO:K09027]
129537221  DDIT3; DNA damage-inducible transcript 3 protein [KO:K04452]
129544549  ERN1; serine/threonine-protein kinase/endoribonuclease IRE1 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
129539222  EIF2AK3; eukaryotic translation initiation factor 2-alpha kinase 3 isoform X1 [KO:K08860] [EC:2.7.11.1]
129539173  TRAF2; TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
129560696  MAP3K5; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
129558655  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
129559467  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
129561625  MAPK10; mitogen-activated protein kinase 10 [KO:K04440] [EC:2.7.11.24]
129555633  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
129562722  EIF2S1; eukaryotic translation initiation factor 2 subunit 1 isoform X1 [KO:K03237]
129536687  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
129540547  LOW QUALITY PROTEIN: cyclic AMP-dependent transcription factor ATF-4-like [KO:K04374]
129550517  PSMA6; proteasome subunit alpha type-6 [KO:K02730] [EC:3.4.25.1]
129552575  PSMA2; proteasome subunit alpha type-2 [KO:K02726] [EC:3.4.25.1]
129550408  PSMA4; proteasome subunit alpha type-4 [KO:K02728] [EC:3.4.25.1]
129549718  PSMA8; proteasome subunit alpha-type 8 [KO:K02731] [EC:3.4.25.1]
129561363  PSMA7; proteasome subunit alpha type-7 [KO:K02731] [EC:3.4.25.1]
129541114  PSMA5; proteasome subunit alpha type-5 [KO:K02729] [EC:3.4.25.1]
129554486  PSMA1; proteasome subunit alpha type-1 [KO:K02725] [EC:3.4.25.1]
129562420  PSMA3; proteasome subunit alpha type-3 isoform X1 [KO:K02727] [EC:3.4.25.1]
129562506  proteasome subunit alpha type-3-like [KO:K02727] [EC:3.4.25.1]
129537072  PSMB6; proteasome subunit beta type-6 [KO:K02738] [EC:3.4.25.1]
129539899  PSMB7; proteasome subunit beta type-7 [KO:K02739] [EC:3.4.25.1]
129544336  PSMB3; proteasome subunit beta type-3 [KO:K02735] [EC:3.4.25.1]
129540914  PSMB2; proteasome subunit beta type-2 [KO:K02734] [EC:3.4.25.1]
129562452  PSMB5; proteasome subunit beta type-5 [KO:K02737] [EC:3.4.25.1]
129560868  PSMB1; proteasome subunit beta type-1 [KO:K02732] [EC:3.4.25.1]
129540647  PSMB4; proteasome subunit beta type-4 [KO:K02736] [EC:3.4.25.1]
129552369  PSMC2; 26S proteasome regulatory subunit 7 [KO:K03061]
129562511  PSMC1; 26S proteasome regulatory subunit 4 [KO:K03062]
129546821  PSMC4; 26S proteasome regulatory subunit 6B [KO:K03063]
129562650  PSMC6; 26S proteasome regulatory subunit 10B [KO:K03064]
129554823  PSMC3; 26S proteasome regulatory subunit 6A [KO:K03065]
129544542  PSMC5; 26S proteasome regulatory subunit 8 isoform X1 [KO:K03066]
129545229  PSMD2; 26S proteasome non-ATPase regulatory subunit 2 [KO:K03028]
129538585  PSMD1; 26S proteasome non-ATPase regulatory subunit 1 [KO:K03032]
129544367  PSMD3; 26S proteasome non-ATPase regulatory subunit 3 [KO:K03033]
129542628  PSMD9; 26S proteasome non-ATPase regulatory subunit 9 [KO:K06693]
129544562  PSMD12; 26S proteasome non-ATPase regulatory subunit 12 [KO:K03035]
129540095  PSMD11; 26S proteasome non-ATPase regulatory subunit 11 [KO:K03036]
129547987  PSMD6; 26S proteasome non-ATPase regulatory subunit 6 [KO:K03037]
129546950  PSMD7; 26S proteasome non-ATPase regulatory subunit 7 [KO:K03038]
129548583  PSMD13; 26S proteasome non-ATPase regulatory subunit 13 [KO:K03039]
129549582  LOW QUALITY PROTEIN: 26S proteasome non-ATPase regulatory subunit 4-like [KO:K03029]
129548374  LOW QUALITY PROTEIN: 26S proteasome non-ATPase regulatory subunit 4-like [KO:K03029]
129537555  PSMD14; 26S proteasome non-ATPase regulatory subunit 14 [KO:K03030]
129546868  PSMD8; 26S proteasome non-ATPase regulatory subunit 8 [KO:K03031]
129561284  ADRM1; proteasomal ubiquitin receptor ADRM1 isoform X1 [KO:K06691]
129542907  NOS1; nitric oxide synthase, brain isoform X1 [KO:K13240] [EC:1.14.13.39]
129548783  CAPN1; calpain-1 catalytic subunit isoform X1 [KO:K01367] [EC:3.4.22.52]
129551654  CAPN2; calpain-2 catalytic subunit [KO:K03853] [EC:3.4.22.53]
129540088  CDK5R1; cyclin-dependent kinase 5 activator 1 [KO:K11716]
129563130  SLC39A2; zinc transporter ZIP2 isoform X1 [KO:K14709]
129559259  SLC39A3; zinc transporter ZIP3 isoform X1 [KO:K14709]
129540566  SLC39A1; zinc transporter ZIP1 [KO:K14709]
129560204  SLC39A4; zinc transporter ZIP4 [KO:K14710]
129535906  SLC39A5; zinc transporter ZIP5 isoform X1 [KO:K14711]
129549621  SLC39A6; zinc transporter ZIP6 [KO:K14712]
129543408  SLC39A7; zinc transporter SLC39A7 [KO:K14713]
129561519  SLC39A8; metal cation symporter ZIP8 isoform X1 [KO:K14714]
129562772  SLC39A9; zinc transporter ZIP9 [KO:K14715]
129537604  SLC39A10; zinc transporter ZIP10 [KO:K14716]
129544767  SLC39A11; zinc transporter ZIP11 isoform X1 [KO:K14717]
129558394  SLC39A12; zinc transporter ZIP12 [KO:K14718]
129554822  SLC39A13; LOW QUALITY PROTEIN: zinc transporter ZIP13 [KO:K14719]
129556886  SLC39A14; metal cation symporter ZIP14 isoform X1 [KO:K14720]
129535617  natural resistance-associated macrophage protein 2-like [KO:K21398]
129535619  natural resistance-associated macrophage protein 2-like isoform X1 [KO:K21398]
129537284  natural resistance-associated macrophage protein 2 isoform X1 [KO:K21398]
129552787  CDK5; cyclin-dependent kinase 5 isoform X1 [KO:K02090] [EC:2.7.11.22]
129561928  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
129555337  CASP7; caspase-7 [KO:K04397] [EC:3.4.22.60]
129555987  DKK1; dickkopf-related protein 1 [KO:K02165]
129549242  DKK4; dickkopf-related protein 4 [KO:K02165]
129558446  dickkopf-related protein 1-like [KO:K02165]
129561544  DKK2; dickkopf-related protein 2 [KO:K02165]
129537207  WNT1; proto-oncogene Wnt-1 [KO:K03209]
129552418  WNT2; protein Wnt-2 [KO:K00182]
129540551  WNT2B; protein Wnt-2b [KO:K00182]
129544517  WNT3; proto-oncogene Wnt-3 isoform X1 [KO:K00312]
129559369  WNT3A; protein Wnt-3a [KO:K00312]
129537869  WNT4; protein Wnt-4 [KO:K00408]
129536617  WNT5B; protein Wnt-5b [KO:K00444]
129547940  WNT5A; protein Wnt-5a isoform X1 [KO:K00444]
129538448  WNT6; protein Wnt-6 [KO:K00445]
129535866  WNT7B; protein Wnt-7b isoform X1 [KO:K00572]
129547565  WNT7A; protein Wnt-7a isoform X1 [KO:K00572]
129559474  WNT8A; protein Wnt-8a [KO:K00714]
129555445  WNT8B; protein Wnt-8b [KO:K00714]
129544516  WNT9B; protein Wnt-9b [KO:K01064]
129559078  WNT9A; protein Wnt-9a [KO:K01064]
129536576  WNT10B; protein Wnt-10b [KO:K01357]
129538439  WNT10A; protein Wnt-10a [KO:K01357]
129554693  WNT11; protein Wnt-11 [KO:K01384]
129552596  WNT16; protein Wnt-16 [KO:K01558]
129538169  FZD7; frizzled-7 [KO:K02432]
129552206  FZD1; frizzled-1 [KO:K02432]
129537813  FZD2; frizzled-2 [KO:K02235]
129557498  FZD3; frizzled-3 [KO:K02329]
129549073  FZD4; frizzled-4 [KO:K02354]
129557900  FZD8; frizzled-8 [KO:K02375]
129537548  FZD5; frizzled-5 [KO:K02375]
129560137  FZD6; frizzled-6 [KO:K02376]
129542780  FZD10; frizzled-10 [KO:K02842]
129545133  FZD9; frizzled-9 [KO:K02842]
129537032  LRP6; low-density lipoprotein receptor-related protein 6 isoform X1 [KO:K03068]
129548675  LRP5; low-density lipoprotein receptor-related protein 5 isoform X1 [KO:K03068]
129535874  CSNK1E; casein kinase I isoform X1 [KO:K08960] [EC:2.7.11.1]
129542604  DVL2; segment polarity protein dishevelled homolog DVL-2 isoform X1 [KO:K02353]
129551414  DVL1; segment polarity protein dishevelled homolog DVL-1 isoform X1 [KO:K02353]
129545265  DVL3; segment polarity protein dishevelled homolog DVL-3 [KO:K02353]
129555496  FRAT1; proto-oncogene FRAT1 [KO:K03069]
129559989  GSK-3-binding protein FRAT2-like [KO:K03096]
129555495  FRAT2; GSK-3-binding protein FRAT2 [KO:K03096]
129547060  CSNK2A2; casein kinase II subunit alpha' [KO:K03097] [EC:2.7.11.1]
129561950  CSNK2A1; casein kinase II subunit alpha [KO:K03097] [EC:2.7.11.1]
129543628  CSNK2B; casein kinase II subunit beta [KO:K03115]
129545182  AXIN1; axin-1 isoform X1 [KO:K02157]
129544790  AXIN2; axin-2 isoform X1 [KO:K04385]
129563180  APC; adenomatous polyposis coli protein isoform X1 [KO:K02085]
129559054  APC2; adenomatous polyposis coli protein 2 isoform X1 [KO:K02085]
129561134  LOW QUALITY PROTEIN: catenin beta-1-like [KO:K02105]
129548107  CTNNB1; catenin beta-1 [KO:K02105]
129563966  casein kinase I-like [KO:K08957] [EC:2.7.11.1]
129564367  casein kinase I-like [KO:K08957] [EC:2.7.11.1]
129559546  CSNK1A1; casein kinase I isoform X1 [KO:K08957] [EC:2.7.11.1]
129535164  LOW QUALITY PROTEIN: casein kinase I-like [KO:K08957] [EC:2.7.11.1]
129535165  casein kinase I-like [KO:K08957] [EC:2.7.11.1]
129535944  KIF5A; kinesin heavy chain [KO:K10396]
129558468  KIF5B; kinesin-1 heavy chain isoform X1 [KO:K10396]
129538351  KIF5C; kinesin heavy chain [KO:K10396]
129543512  KLC4; kinesin light chain 4 [KO:K10407]
129550693  KLC1; kinesin light chain 1 isoform X1 [KO:K10407]
129546675  KLC3; kinesin light chain 3 [KO:K10407]
129548736  KLC2; kinesin light chain 2 isoform X1 [KO:K10407]
129536409  TUBA8; tubulin alpha-8 chain [KO:K07374]
129536741  LOW QUALITY PROTEIN: tubulin alpha-1B chain-like [KO:K07374]
129536760  tubulin alpha-1A chain isoform X1 [KO:K07374]
129536761  tubulin alpha-1C chain isoform X1 [KO:K07374]
129536762  tubulin alpha-1C chain-like isoform X1 [KO:K07374]
129537982  tubulin alpha-4A chain [KO:K07374]
129538092  tubulin alpha-1D chain isoform X1 [KO:K07374]
129554739  TUBAL3; tubulin alpha chain-like 3 [KO:K07374]
129543045  tubulin beta-4B chain-like [KO:K07375]
129543147  TUBB; tubulin beta chain [KO:K07375]
129543421  tubulin beta-2B chain [KO:K07375]
129549800  TUBB6; tubulin beta-6 chain [KO:K07375]
129543715  TUBB2A; tubulin beta-2A chain [KO:K07375]
129558972  tubulin beta chain-like [KO:K07375]
129559232  TUBB4A; tubulin beta-4A chain [KO:K07375]
129539645  TUBB4B; tubulin beta-4B chain [KO:K07375]
129561483  TUBB1; tubulin beta-1 chain [KO:K07375]
129547355  uncharacterized protein LOC129547355 [KO:K07375]
129543130  AGER; advanced glycosylation end product-specific receptor isoform X1 [KO:K19722]
129548597  HRAS; GTPase HRas isoform X1 [KO:K02833]
129537164  KRAS; GTPase KRas isoform X1 [KO:K07827]
129541808  NRAS; GTPase NRas [KO:K07828]
129564326  ARAF; serine/threonine-protein kinase A-Raf isoform X1 [KO:K08845] [EC:2.7.11.1]
129552712  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
129547721  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
129562372  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
129558523  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
129564165  NOX1; LOW QUALITY PROTEIN: NADPH oxidase 1 [KO:K08008]
129564517  cytochrome b-245 heavy chain [KO:K21421] [EC:1.-.-.-]
129549082  NOX4; NADPH oxidase 4 isoform X1 [KO:K21423] [EC:1.6.3.-]
129548767  RELA; transcription factor p65 [KO:K04735]
129562101  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
129540556  NOS2; nitric oxide synthase, inducible isoform X1 [KO:K13241] [EC:1.14.13.39]
129551280  PTGS2; prostaglandin G/H synthase 2 [KO:K11987] [EC:1.14.99.1]
129543262  TNF; tumor necrosis factor isoform X1 [KO:K03156]
129539790  IL1A; interleukin-1 alpha [KO:K04383]
129539906  IL1B; interleukin-1 beta [KO:K04519]
129541681  CSF1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453]
129562012  SNCA; alpha-synuclein [KO:K04528]
129539119  EIF2AK2; interferon-induced, double-stranded RNA-activated protein kinase isoform X1 [KO:K16195] [EC:2.7.11.1]
129555451  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
129549430  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
129564146  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
129548407  INS; insulin [KO:K04526]
129558099  INSR; insulin receptor isoform X1 [KO:K04527] [EC:2.7.10.1]
129537506  IRS1; insulin receptor substrate 1 [KO:K16172]
129556507  IRS2; insulin receptor substrate 2 isoform X1 [KO:K07187]
129545680  insulin receptor substrate 1-like isoform X1 [KO:K17445]
129564117  IRS4; LOW QUALITY PROTEIN: insulin receptor substrate 4 [KO:K17446]
129559156  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
129553207  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha [KO:K02649]
129540801  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
129551508  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
129547146  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
129550706  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
129551602  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
129546814  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
129551531  MTOR; serine/threonine-protein kinase mTOR isoform X1 [KO:K07203] [EC:2.7.11.1]
129542526  ULK1; serine/threonine-protein kinase ULK1 [KO:K21357] [EC:2.7.11.1]
129544195  ULK2; serine/threonine-protein kinase ULK2 isoform X1 [KO:K08269] [EC:2.7.11.1]
129535748  ATG101; autophagy-related protein 101 isoform X1 [KO:K19730]
129554798  ATG13; autophagy-related protein 13 isoform X1 [KO:K08331]
129559855  RB1CC1; RB1-inducible coiled-coil protein 1 [KO:K17589]
129554797  AMBRA1; activating molecule in BECN1-regulated autophagy protein 1 isoform X1 [KO:K17985]
129550493  LOW QUALITY PROTEIN: beclin-1-like [KO:K08334]
129551103  BECN2; beclin-2 [KO:K08334]
129544444  BECN1; beclin-1 [KO:K08334]
129552091  beclin-2-like [KO:K08334]
129540359  beclin-2-like [KO:K08334]
129549374  PIK3R4; phosphoinositide 3-kinase regulatory subunit 4 isoform X1 [KO:K08333] [EC:2.7.11.1]
129563556  ATG14; beclin 1-associated autophagy-related key regulator [KO:K17889]
129555797  NRBF2; nuclear receptor-binding factor 2 [KO:K21246]
129549677  PIK3C3; phosphatidylinositol 3-kinase catalytic subunit type 3 [KO:K00914] [EC:2.7.1.137]
129548797  ATG2A; autophagy-related protein 2 homolog A [KO:K17906]
129550628  ATG2B; autophagy-related protein 2 homolog B isoform X1 [KO:K17906]
129544785  WIPI1; WD repeat domain phosphoinositide-interacting protein 1 isoform X1 [KO:K17908]
129545777  WIPI2; WD repeat domain phosphoinositide-interacting protein 2 [KO:K17908]
Compound
C00027  Hydrogen peroxide
C00038  Zinc cation
C00070  Copper
C00076  Calcium cation
C00533  Nitric oxide
C00704  Superoxide
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01319  Hg
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C14818  Fe2+
C16514  Amyloid beta protein 40
C16515  Amyloid beta protein 42
C16845  Peroxynitrite
C19610  Manganese(2+)
C21011  [Protein]-N(epsilon)-(carboxymethyl)lysine
C21012  [Protein]-N(epsilon)-(carboxyethyl)lysine
C21013  [Protein]-pyrraline
C21014  [Protein]-pentosidine
Reference
PMID:15232608
  Authors
Dickson DW
  Title
Apoptotic mechanisms in Alzheimer neurofibrillary degeneration: cause or effect?
  Journal
J Clin Invest 114:23-7 (2004)
DOI:10.1172/JCI22317
Reference
PMID:15750290
  Authors
Takuma K, Yan SS, Stern DM, Yamada K
  Title
Mitochondrial dysfunction, endoplasmic reticulum stress, and apoptosis in Alzheimer's disease.
  Journal
J Pharmacol Sci 97:312-6 (2005)
DOI:10.1254/jphs.CPJ04006X
Reference
PMID:18675468
  Authors
Bezprozvanny I, Mattson MP
  Title
Neuronal calcium mishandling and the pathogenesis of Alzheimer's disease.
  Journal
Trends Neurosci 31:454-63 (2008)
DOI:10.1016/j.tins.2008.06.005
Reference
PMID:9848086
  Authors
Holscher C
  Title
Possible causes of Alzheimer's disease: amyloid fragments, free radicals, and calcium homeostasis.
  Journal
Neurobiol Dis 5:129-41 (1998)
DOI:10.1006/nbdi.1998.0193
Reference
PMID:18035450
  Authors
Bojarski L, Herms J, Kuznicki J
  Title
Calcium dysregulation in Alzheimer's disease.
  Journal
Neurochem Int 52:621-33 (2008)
DOI:10.1016/j.neuint.2007.10.002
Reference
PMID:25450339
  Authors
Kondratskyi A, Kondratska K, Skryma R, Prevarskaya N
  Title
Ion channels in the regulation of apoptosis.
  Journal
Biochim Biophys Acta 1848:2532-46 (2015)
DOI:10.1016/j.bbamem.2014.10.030
Reference
PMID:29890840
  Authors
Popugaeva E, Pchitskaya E, Bezprozvanny I
  Title
Dysregulation of Intracellular Calcium Signaling in Alzheimer's Disease.
  Journal
Antioxid Redox Signal 29:1176-1188 (2018)
DOI:10.1089/ars.2018.7506
Reference
PMID:25767489
  Authors
Tan Y, Deng Y, Qing H
  Title
Calcium channel blockers and Alzheimer's disease.
  Journal
Neural Regen Res 7:137-40 (2012)
DOI:10.3969/j.issn.1673-5374.2012.02.010
Reference
PMID:11484003
  Authors
Small DH, Mok SS, Bornstein JC
  Title
Alzheimer's disease and Abeta toxicity: from top to bottom.
  Journal
Nat Rev Neurosci 2:595-8 (2001)
DOI:10.1038/35086072
Reference
PMID:15177383
  Authors
Parihar MS, Hemnani T
  Title
Alzheimer's disease pathogenesis and therapeutic interventions.
  Journal
J Clin Neurosci 11:456-67 (2004)
DOI:10.1016/j.jocn.2003.12.007
Reference
PMID:17568632
  Authors
Cowburn RF, Popescu BO, Ankarcrona M, Dehvari N, Cedazo-Minguez A
  Title
Presenilin-mediated signal transduction.
  Journal
Physiol Behav 92:93-7 (2007)
DOI:10.1016/j.physbeh.2007.05.053
Reference
PMID:22842534
  Authors
Honarnejad K, Herms J
  Title
Presenilins: role in calcium homeostasis.
  Journal
Int J Biochem Cell Biol 44:1983-6 (2012)
DOI:10.1016/j.biocel.2012.07.019
Reference
PMID:21663966
  Authors
Supnet C, Bezprozvanny I
  Title
Presenilins function in ER calcium leak and Alzheimer's disease pathogenesis.
  Journal
Cell Calcium 50:303-9 (2011)
DOI:10.1016/j.ceca.2011.05.013
Reference
PMID:16677790
  Authors
Hauptmann S, Keil U, Scherping I, Bonert A, Eckert A, Muller WE
  Title
Mitochondrial dysfunction in sporadic and genetic Alzheimer's disease.
  Journal
Exp Gerontol 41:668-73 (2006)
DOI:10.1016/j.exger.2006.03.012
Reference
PMID:14557245
  Authors
Chen Y, Liu W, McPhie DL, Hassinger L, Neve RL
  Title
APP-BP1 mediates APP-induced apoptosis and DNA synthesis and is increased in Alzheimer's disease brain.
  Journal
J Cell Biol 163:27-33 (2003)
DOI:10.1083/jcb.200304003
Reference
PMID:24051203
  Authors
Eckert A, Nisbet R, Grimm A, Gotz J
  Title
March separate, strike together--role of phosphorylated TAU in mitochondrial dysfunction in Alzheimer's disease.
  Journal
Biochim Biophys Acta 1842:1258-66 (2014)
DOI:10.1016/j.bbadis.2013.08.013
Reference
PMID:30741722
  Authors
Strickland MR, Holtzman DM
  Title
Dr. Jekyll and Mr. Hyde: ApoE explains opposing effects of neuronal LRP1.
  Journal
J Clin Invest 129:969-971 (2019)
DOI:10.1172/JCI127578
Reference
PMID:10527810
  Authors
Ivins KJ, Thornton PL, Rohn TT, Cotman CW
  Title
Neuronal apoptosis induced by beta-amyloid is mediated by caspase-8.
  Journal
Neurobiol Dis 6:440-9 (1999)
DOI:10.1006/nbdi.1999.0268
Reference
PMID:31655116
  Authors
Sushma, Mondal AC
  Title
Role of GPCR signaling and calcium dysregulation in Alzheimer's disease.
  Journal
Mol Cell Neurosci 101:103414 (2019)
DOI:10.1016/j.mcn.2019.103414
Reference
PMID:18648507
  Authors
Sanz-Blasco S, Valero RA, Rodriguez-Crespo I, Villalobos C, Nunez L
  Title
Mitochondrial Ca2+ overload underlies Abeta oligomers neurotoxicity providing an unexpected mechanism of neuroprotection by NSAIDs.
  Journal
PLoS One 3:e2718 (2008)
DOI:10.1371/journal.pone.0002718
Reference
PMID:20332425
  Authors
Mattson MP
  Title
ER calcium and Alzheimer's disease: in a state of flux.
  Journal
Sci Signal 3:pe10 (2010)
DOI:10.1126/scisignal.3114pe10
Reference
PMID:16394273
  Authors
Lee SY, Hwang DY, Kim YK, Lee JW, Shin IC, Oh KW, Lee MK, Lim JS, Yoon DY, Hwang SJ, Hong JT
  Title
PS2 mutation increases neuronal cell vulnerability to neurotoxicants through activation of caspase-3 by enhancing of ryanodine receptor-mediated calcium release.
  Journal
FASEB J 20:151-3 (2006)
DOI:10.1096/fj.05-4017fje;1
Reference
PMID:11551913
  Authors
Katayama T, Imaizumi K, Honda A, Yoneda T, Kudo T, Takeda M, Mori K, Rozmahel R, Fraser P, George-Hyslop PS, Tohyama M
  Title
Disturbed activation of endoplasmic reticulum stress transducers by familial Alzheimer's disease-linked presenilin-1 mutations.
  Journal
J Biol Chem 276:43446-54 (2001)
DOI:10.1074/jbc.M104096200
Reference
PMID:28057414
  Authors
Lane-Donovan C, Herz J
  Title
ApoE, ApoE Receptors, and the Synapse in Alzheimer's Disease.
  Journal
Trends Endocrinol Metab 28:273-284 (2017)
DOI:10.1016/j.tem.2016.12.001
Reference
PMID:27994051
  Authors
Wasser CR, Herz J
  Title
Reelin: Neurodevelopmental Architect and Homeostatic Regulator of Excitatory Synapses.
  Journal
J Biol Chem 292:1330-1338 (2017)
DOI:10.1074/jbc.R116.766782
Reference
PMID:21116052
  Authors
Lilja AM, Porras O, Storelli E, Nordberg A, Marutle A
  Title
Functional interactions of fibrillar and oligomeric amyloid-beta with alpha7 nicotinic receptors in Alzheimer's disease.
  Journal
J Alzheimers Dis 23:335-47 (2011)
DOI:10.3233/JAD-2010-101242
Reference
PMID:24847263
  Authors
Anastasio TJ
  Title
Computational identification of potential multitarget treatments for ameliorating the adverse effects of amyloid-beta on synaptic plasticity.
  Journal
Front Pharmacol 5:85 (2014)
DOI:10.3389/fphar.2014.00085
Reference
PMID:29378302
  Authors
Vargas LM, Cerpa W, Munoz FJ, Zanlungo S, Alvarez AR
  Title
Amyloid-beta oligomers synaptotoxicity: The emerging role of EphA4/c-Abl signaling in Alzheimer's disease.
  Journal
Biochim Biophys Acta Mol Basis Dis 1864:1148-1159 (2018)
DOI:10.1016/j.bbadis.2018.01.023
Reference
PMID:25394486
  Authors
Tu S, Okamoto S, Lipton SA, Xu H
  Title
Oligomeric Abeta-induced synaptic dysfunction in Alzheimer's disease.
  Journal
Mol Neurodegener 9:48 (2014)
DOI:10.1186/1750-1326-9-48
Reference
PMID:31191253
  Authors
Palomer E, Buechler J, Salinas PC
  Title
Wnt Signaling Deregulation in the Aging and Alzheimer's Brain.
  Journal
Front Cell Neurosci 13:227 (2019)
DOI:10.3389/fncel.2019.00227
Reference
PMID:27807401
  Authors
Vallee A, Lecarpentier Y
  Title
Alzheimer Disease: Crosstalk between the Canonical Wnt/Beta-Catenin Pathway and PPARs Alpha and Gamma.
  Journal
Front Neurosci 10:459 (2016)
DOI:10.3389/fnins.2016.00459
Reference
PMID:19903023
  Authors
Origlia N, Arancio O, Domenici L, Yan SS
  Title
MAPK, beta-amyloid and synaptic dysfunction: the role of RAGE.
  Journal
Expert Rev Neurother 9:1635-45 (2009)
DOI:10.1586/ern.09.107
Reference
PMID:19464758
  Authors
Srikanth V, Maczurek A, Phan T, Steele M, Westcott B, Juskiw D, Munch G
  Title
Advanced glycation endproducts and their receptor RAGE in Alzheimer's disease.
  Journal
Neurobiol Aging 32:763-77 (2011)
DOI:10.1016/j.neurobiolaging.2009.04.016
Reference
PMID:12805290
  Authors
Pigino G, Morfini G, Pelsman A, Mattson MP, Brady ST, Busciglio J
  Title
Alzheimer's presenilin 1 mutations impair kinesin-based axonal transport.
  Journal
J Neurosci 23:4499-508 (2003)
DOI:10.1523/JNEUROSCI.23-11-04499.2003
Reference
PMID:15645263
  Authors
Roy S, Zhang B, Lee VM, Trojanowski JQ
  Title
Axonal transport defects: a common theme in neurodegenerative diseases.
  Journal
Acta Neuropathol 109:5-13 (2005)
DOI:10.1007/s00401-004-0952-x
Reference
PMID:26074767
  Authors
Ferreira ST, Lourenco MV, Oliveira MM, De Felice FG
  Title
Soluble amyloid-beta oligomers as synaptotoxins leading to cognitive impairment in Alzheimer's disease.
  Journal
Front Cell Neurosci 9:191 (2015)
DOI:10.3389/fncel.2015.00191
Reference
PMID:24529521
  Authors
De Felice FG, Lourenco MV, Ferreira ST
  Title
How does brain insulin resistance develop in Alzheimer's disease?
  Journal
Alzheimers Dement 10:S26-32 (2014)
DOI:10.1016/j.jalz.2013.12.004
Reference
PMID:26136647
  Authors
Bedse G, Di Domenico F, Serviddio G, Cassano T
  Title
Aberrant insulin signaling in Alzheimer's disease: current knowledge.
  Journal
Front Neurosci 9:204 (2015)
DOI:10.3389/fnins.2015.00204
Reference
PMID:20101724
  Authors
Funderburk SF, Marcellino BK, Yue Z
  Title
Cell "self-eating" (autophagy) mechanism in Alzheimer's disease.
  Journal
Mt Sinai J Med 77:59-68 (2010)
DOI:10.1002/msj.20161
Related
pathway
mbez00190  Oxidative phosphorylation
mbez03050  Proteasome
mbez04020  Calcium signaling pathway
mbez04140  Autophagy - animal
mbez04141  Protein processing in endoplasmic reticulum
mbez04210  Apoptosis
mbez04310  Wnt signaling pathway
mbez04910  Insulin signaling pathway
mbez04933  AGE-RAGE signaling pathway in diabetic complications
KO pathway
ko05010   
LinkDB

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