KEGG   PATHWAY: mdo05417
Entry
mdo05417                    Pathway                                
Name
Lipid and atherosclerosis - Monodelphis domestica (gray short-tailed opossum)
Description
Atherosclerosis is a chronic inflammatory disease marked by a narrowing of the arteries from lipid-rich plaques present within the walls of arterial blood vessels. It represents the root cause of the majority of cardiovascular diseases (CVDs) and their complications, including conditions such as coronary artery disease, myocardial infarction and stroke.  An elevated level of low density lipoprotein (LDL) cholesterol constitutes a major risk factor for genesis of atherosclerosis. LDL can accumulate within the blood vessel wall and undergo modification by oxidation. Oxidized LDL (oxLDL) leads to endothelial dysfunction leading to expression of adhesion molecules and recruitment of monocyte in subendothelial space. The monocytes proliferate, differentiate into macrophages, and take up the lipoproteins, forming cholesterol-engorged "foam cells." With the time, the foam cells die, leaving a 'necrotic core' of crystalline cholesterol and cell debris. Smooth muscle cells proliferate and migrate into the region, laying down a protective cap over the lesion. Lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1), which mediates the recognition and internalization of oxLDL, is involved in all of these events critical in the pathogenesis of atherosclerosis.
Class
Human Diseases; Cardiovascular disease
Pathway map
mdo05417  Lipid and atherosclerosis
mdo05417

Organism
Monodelphis domestica (gray short-tailed opossum) [GN:mdo]
Gene
554179  APOB; apolipoprotein B [KO:K14462]
100031679  APOA4; apolipoprotein A4 [KO:K08760]
100031668  APOA1; apolipoprotein A1 [KO:K08757]
654363  LDLR; low density lipoprotein receptor [KO:K12473]
100012472  MMP1; interstitial collagenase [KO:K01388] [EC:3.4.24.7]
100021110  RHOA; ras homolog family member A [KO:K04513]
100032706  ROCK2; Rho associated coiled-coil containing protein kinase 2 [KO:K17388] [EC:2.7.11.1]
100018035  NOS3; nitric oxide synthase 3 [KO:K13242] [EC:1.14.13.39]
100010412  PIK3CA; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha [KO:K00922] [EC:2.7.1.153]
100017332  PIK3CB; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta [KO:K00922] [EC:2.7.1.153]
100024769  PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta [KO:K00922] [EC:2.7.1.153]
100019317  PIK3R1; phosphoinositide-3-kinase regulatory subunit 1 [KO:K02649]
100032726  PIK3R2; phosphoinositide-3-kinase regulatory subunit 2 [KO:K02649]
100616957  PIK3R3; phosphoinositide-3-kinase regulatory subunit 3 [KO:K02649]
100014564  AKT2; AKT serine/threonine kinase 2 [KO:K04456] [EC:2.7.11.1]
100019947  AKT1; AKT serine/threonine kinase 1 [KO:K04456] [EC:2.7.11.1]
100027373  AKT3; AKT serine/threonine kinase 3 [KO:K04456] [EC:2.7.11.1]
100030412  BAX; BCL2 associated X, apoptosis regulator [KO:K02159]
100031246  BAD; BCL2 associated agonist of cell death [KO:K02158]
100010654  BCL2L1; BCL2 like 1 [KO:K04570]
100016570  BCL2; BCL2, apoptosis regulator [KO:K02161]
100028089  MAPK9; mitogen-activated protein kinase 9 [KO:K04440] [EC:2.7.11.24]
100618895  MAPK10; mitogen-activated protein kinase 10 [KO:K04440] [EC:2.7.11.24]
100032426  SOD2; superoxide dismutase 2 [KO:K04564] [EC:1.15.1.1]
100024674  PRKCA; protein kinase C alpha [KO:K02677] [EC:2.7.11.13]
100618168  POU2F1; POU class 2 homeobox 1 [KO:K09364]
100030936  POU2F3; POU class 2 homeobox 3 [KO:K09364]
100022240  CD40; CD40 molecule [KO:K03160]
100010217  CD40LG; CD40 ligand [KO:K03161]
100029871  cytochrome P450 1A1 [KO:K07408] [EC:1.14.14.1]
100018958  cytochrome P450 2B6-like [KO:K17709] [EC:1.14.14.-]
100031971  cytochrome P450 2J2-like [KO:K07418] [EC:1.14.14.1 1.14.14.73 1.14.14.74 1.14.14.75]
100031902  cytochrome P450 2J2-like [KO:K07418] [EC:1.14.14.1 1.14.14.73 1.14.14.74 1.14.14.75]
100031907  cytochrome P450 2J1-like [KO:K07418] [EC:1.14.14.1 1.14.14.73 1.14.14.74 1.14.14.75]
100031980  cytochrome P450 2J2-like [KO:K07418] [EC:1.14.14.1 1.14.14.73 1.14.14.74 1.14.14.75]
100031984  cytochrome P450 2J2-like [KO:K07418] [EC:1.14.14.1 1.14.14.73 1.14.14.74 1.14.14.75]
100031975  cytochrome P450 2J2-like [KO:K07418] [EC:1.14.14.1 1.14.14.73 1.14.14.74 1.14.14.75]
100031914  cytochrome P450 2J2-like [KO:K07418] [EC:1.14.14.1 1.14.14.73 1.14.14.74 1.14.14.75]
100031960  cytochrome P450 2J2-like [KO:K07418] [EC:1.14.14.1 1.14.14.73 1.14.14.74 1.14.14.75]
100024116  AGER; advanced glycosylation end-product specific receptor [KO:K19722]
100017914  cytochrome b-245 heavy chain [KO:K21421] [EC:1.-.-.-]
100014144  NCF1; neutrophil cytosolic factor 1 [KO:K08011]
100026086  uncharacterized LOC100026086 [KO:K08009]
100024184  NCF2; neutrophil cytosolic factor 2 [KO:K08010]
100025111  NCF4; neutrophil cytosolic factor 4 [KO:K08012]
100026992  RAC1; ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) [KO:K04392]
100029391  SRC; SRC proto-oncogene, non-receptor tyrosine kinase [KO:K05704] [EC:2.7.10.2]
100017930  JAK2; Janus kinase 2 [KO:K04447] [EC:2.7.10.2]
100011382  STAT3; signal transducer and activator of transcription 3 [KO:K04692]
100023099  CDC42; cell division cycle 42 [KO:K04393]
100009767  cell division control protein 42 homolog [KO:K04393]
100019828  MAP2K4; mitogen-activated protein kinase kinase 4 [KO:K04430] [EC:2.7.12.2]
100026752  MAP2K7; mitogen-activated protein kinase kinase 7 [KO:K04431] [EC:2.7.12.2]
100018285  FOS; Fos proto-oncogene, AP-1 transcription factor subunit [KO:K04379]
100018774  JUN; Jun proto-oncogene, AP-1 transcription factor subunit [KO:K04448]
103093665  C-C motif chemokine 2-like [KO:K14624]
100023722  IL8; interleukin-8 [KO:K10030]
100016872  MAP2K3; mitogen-activated protein kinase kinase 3 [KO:K04432] [EC:2.7.12.2]
100029049  MAP2K6; mitogen-activated protein kinase kinase 6 [KO:K04433] [EC:2.7.12.2]
100010279  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
100010891  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
100026324  MAPK14; mitogen-activated protein kinase 14 [KO:K04441] [EC:2.7.11.24]
100028821  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
100032921  HRAS; HRas proto-oncogene, GTPase [KO:K02833]
554186  KRAS; KRAS proto-oncogene, GTPase [KO:K07827]
554197  NRAS; neuroblastoma RAS viral oncogene homolog [KO:K07828]
100022523  GTPase NRas-like [KO:K07828]
100028096  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
100012916  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
100030053  RELA; RELA proto-oncogene, NF-kB subunit [KO:K04735]
100014446  NFKB1; nuclear factor kappa B subunit 1 [KO:K02580]
100019509  SELE; selectin E [KO:K06494]
100019433  SELP; selectin P [KO:K06496]
100032965  VCAM1; vascular cell adhesion molecule 1 [KO:K06527]
100011059  MMP3; stromelysin-1 [KO:K01394] [EC:3.4.24.17]
100022144  MMP9; matrix metallopeptidase 9 [KO:K01403] [EC:3.4.24.35]
100026024  IL1B; interleukin 1 beta [KO:K04519]
103104339  IL6; interleukin 6 [KO:K05405]
100023069  TNF; tumor necrosis factor [KO:K03156]
100022262  HSPD1; heat shock protein family D (Hsp60) member 1 [KO:K04077] [EC:5.6.1.7]
100030633  HSPA8; heat shock protein family A (Hsp70) member 8 [KO:K03283]
100023576  HSPA1L; heat shock 70 kDa protein 1-like [KO:K03283]
100023597  HSPA1A; heat shock 70 kDa protein 1 [KO:K03283]
100015032  heat shock 70 kDa protein 6-like [KO:K03283]
100011711  heat shock 70 kDa protein 6-like [KO:K03283]
103100712  heat shock cognate 71 kDa protein-like [KO:K03283]
100032797  heat shock protein SSC1, mitochondrial-like [KO:K03283]
100022532  HSPA2; heat shock protein family A (Hsp70) member 2 [KO:K26598]
100015971  HSPA4; heat shock protein family A (Hsp70) member 4 [KO:K09489]
100017761  HSP90AA1; heat shock protein 90 alpha family class A member 1 [KO:K04079]
100013102  HSP90AB1; heat shock protein 90 alpha family class B member 1 [KO:K04079]
100014854  HSP90B1; heat shock protein 90 beta family member 1 [KO:K09487]
100024558  TLR2; toll like receptor 2 [KO:K10159]
100032863  LBP; lipopolysaccharide-binding protein [KO:K05399]
100026364  CD14; CD14 molecule [KO:K04391]
100027990  LY96; lymphocyte antigen 96 [KO:K05400]
100014467  TLR4; toll like receptor 4 [KO:K10160]
100019477  TIRAP; TIR domain containing adaptor protein [KO:K05403]
100019202  IRAK4; interleukin 1 receptor associated kinase 4 [KO:K04733] [EC:2.7.11.1]
100029477  IRAK1; interleukin 1 receptor associated kinase 1 [KO:K04730] [EC:2.7.11.1]
100010055  TRAF6; TNF receptor associated factor 6 [KO:K03175] [EC:2.3.2.27]
100012432  TAB1; TGF-beta activated kinase 1 (MAP3K7) binding protein 1 [KO:K04403]
100026855  TAB2; TGF-beta activated kinase 1/MAP3K7 binding protein 2 [KO:K04404]
100019975  MAP3K7; mitogen-activated protein kinase kinase kinase 7 [KO:K04427] [EC:2.7.11.25]
100027952  CHUK; conserved helix-loop-helix ubiquitous kinase [KO:K04467] [EC:2.7.11.10]
100033031  IKBKB; inhibitor of nuclear factor kappa B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
100022918  IKBKG; inhibitor of nuclear factor kappa B kinase subunit gamma [KO:K07210]
100011769  NFKBIA; NFKB inhibitor alpha [KO:K04734]
100029323  TICAM2; toll like receptor adaptor molecule 2 [KO:K05409]
100023610  TICAM1; toll like receptor adaptor molecule 1 [KO:K05842]
100017361  TRAF3; TNF receptor associated factor 3 [KO:K03174]
100011183  MIB1; mindbomb E3 ubiquitin protein ligase 1 [KO:K10645] [EC:2.3.2.27]
100012507  MIB2; mindbomb E3 ubiquitin protein ligase 2 [KO:K10645] [EC:2.3.2.27]
100022154  TANK; TRAF family member associated NFKB activator [KO:K12650]
100019578  IKBKE; inhibitor of nuclear factor kappa B kinase subunit epsilon [KO:K07211] [EC:2.7.11.10]
100030239  IRF3; interferon regulatory factor 3 [KO:K05411]
100021311  IFN7; type I interferon 7 [KO:K05414]
100021419  interferon tau-2-like [KO:K05414]
100021467  interferon alpha-16-like [KO:K05414]
100021290  IFN3; type I interferon 3 [KO:K05414]
100021340  IFN4; type I interferon 4 [KO:K05414]
100021368  interferon tau-2-like [KO:K05414]
100021487  IFN2; type I interferon 2 [KO:K05414]
100021258  IFNB1; interferon beta [KO:K05415]
100012876  CD36; CD36 molecule [KO:K06259]
100025091  PPARG; peroxisome proliferator activated receptor gamma [KO:K08530]
100019466  RXRA; retinoid X receptor alpha [KO:K08524]
100027006  RXRB; retinoid X receptor beta [KO:K08525]
100016615  RXRG; retinoid X receptor gamma [KO:K08526]
100616821  LYN; LYN proto-oncogene, Src family tyrosine kinase [KO:K05854] [EC:2.7.10.2]
100027188  PTK2; protein tyrosine kinase 2 [KO:K05725] [EC:2.7.10.2]
100029844  VAV3; vav guanine nucleotide exchange factor 3 [KO:K05730]
100015350  VAV2; guanine nucleotide exchange factor VAV2 [KO:K05730]
100020150  VAV1; vav guanine nucleotide exchange factor 1 [KO:K05730]
100617999  TLR6; toll like receptor 6 [KO:K10169]
100033128  RAP1A; RAP1A, member of RAS oncogene family [KO:K04353]
100014092  RAP1B; RAP1B, member of RAS oncogene family [KO:K07836]
100021011  CCL5; C-C motif chemokine ligand 5 [KO:K12499]
103100967  C-C motif chemokine 5-like [KO:K05408]
103101147  C-C motif chemokine 3-like [KO:K05408]
100022317  C-C motif chemokine 3-like 1 [KO:K05408]
100023783  CXCL1; growth-regulated alpha protein [KO:K05505]
100018516  IL12A; interleukin 12A [KO:K05406]
100030276  IL12B; interleukin 12B [KO:K05425]
103102395  interleukin-18-like [KO:K05482]
103101367  interleukin-18-like [KO:K05482]
103101192  interleukin-18-like [KO:K05482]
100015941  HSPA5; heat shock protein family A (Hsp70) member 5 [KO:K09490] [EC:3.6.4.10]
100015495  ATF6; activating transcription factor 6 [KO:K09054]
100015490  ERO1A; endoplasmic reticulum oxidoreductase 1 alpha [KO:K10950] [EC:1.8.4.-]
100013305  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 [KO:K04958]
100011784  CAMK2D; calcium/calmodulin dependent protein kinase II delta [KO:K04515] [EC:2.7.11.17]
100010898  CAMK2G; calcium/calmodulin dependent protein kinase II gamma [KO:K04515] [EC:2.7.11.17]
100024521  CAMK2B; calcium/calmodulin dependent protein kinase II beta [KO:K04515] [EC:2.7.11.17]
100028973  CAMK2A; calcium/calmodulin dependent protein kinase II alpha [KO:K04515] [EC:2.7.11.17]
100029557  EIF2AK3; eukaryotic translation initiation factor 2 alpha kinase 3 [KO:K08860] [EC:2.7.11.1]
100023094  EIF2S1; eukaryotic translation initiation factor 2 subunit alpha [KO:K03237]
100012224  ATF4; activating transcription factor 4 [KO:K04374]
100026418  ERN1; endoplasmic reticulum to nucleus signaling 1 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
100017243  TRAF2; TNF receptor associated factor 2 [KO:K03173] [EC:2.3.2.27]
100031527  MAP3K5; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
100030619  XBP1; X-box binding protein 1 [KO:K09027]
100013781  ABCA1; ATP binding cassette subfamily A member 1 [KO:K05641]
100014129  ABCG1; ATP binding cassette subfamily G member 1 [KO:K05679]
100026605  NFE2L2; nuclear factor, erythroid 2 like 2 [KO:K05638]
100016983  apoptosis-associated speck-like protein containing a CARD [KO:K12799]
100032596  caspase-1-like [KO:K01370] [EC:3.4.22.36]
100032610  caspase-1-like [KO:K01370] [EC:3.4.22.36]
100032592  caspase-1-like [KO:K01370] [EC:3.4.22.36]
100022696  VLDLR; very low density lipoprotein receptor [KO:K20053]
100018830  PDPK1; 3-phosphoinositide-dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
100012447  GSK3B; glycogen synthase kinase 3 beta [KO:K03083] [EC:2.7.11.26]
100023153  NFATC1; nuclear factor of activated T-cells 1 [KO:K04446]
100028435  NFATC2; nuclear factor of activated T-cells 2 [KO:K17332]
100021991  NFATC3; nuclear factor of activated T-cells 3 [KO:K17333]
100033281  PLCB4; phospholipase C beta 4 [KO:K05858] [EC:3.1.4.11]
100031660  PLCB1; phospholipase C beta 1 [KO:K05858] [EC:3.1.4.11]
100031869  PLCB2; phospholipase C beta 2 [KO:K05858] [EC:3.1.4.11]
100031263  PLCB3; phospholipase C beta 3 [KO:K05858] [EC:3.1.4.11]
100032696  PLCG1; phospholipase C gamma 1 [KO:K01116] [EC:3.1.4.11]
100021688  CALM3; calmodulin 3 [KO:K02183]
100018191  CALM1; calmodulin 1 [KO:K02183]
100032171  CALM2; calmodulin 2 [KO:K02183]
100025795  CALML4; calmodulin like 4 [KO:K02183]
100015722  calmodulin-alpha-like [KO:K02183]
100022649  calmodulin-alpha-like [KO:K02183]
100014900  PPP3CA; protein phosphatase 3 catalytic subunit alpha [KO:K04348] [EC:3.1.3.16]
100011077  PPP3CB; protein phosphatase 3 catalytic subunit beta [KO:K04348] [EC:3.1.3.16]
100033104  PPP3CC; protein phosphatase 3 catalytic subunit gamma [KO:K04348] [EC:3.1.3.16]
100033302  PPP3R1; protein phosphatase 3 regulatory subunit B, alpha [KO:K06268]
100010299  TNFSF10; tumor necrosis factor superfamily member 10 [KO:K04721]
103100524  TNFRSF10A; tumor necrosis factor receptor superfamily member 10A [KO:K04722]
103104450  TNFRSF1A; TNF receptor superfamily member 1A [KO:K03158]
100017025  CASP18; caspase-18 [KO:K04398] [EC:3.4.22.61]
100617599  CASP8; caspase-8 [KO:K04398] [EC:3.4.22.61]
100021895  BID; BH3 interacting domain death agonist [KO:K04726]
100010620  cytochrome c [KO:K08738]
100026811  cytochrome c, testis-specific-like [KO:K08738]
100013051  APAF1; apoptotic peptidase activating factor 1 [KO:K02084]
100027338  CASP9; caspase 9 [KO:K04399] [EC:3.4.22.62]
100009858  CASP6; caspase 6 [KO:K04396] [EC:3.4.22.59]
100019753  caspase-6-like [KO:K04396] [EC:3.4.22.59]
654273  CASP3; caspase 3 [KO:K02187] [EC:3.4.22.56]
654275  caspase-3-like protein 2 [KO:K02187] [EC:3.4.22.56]
100027500  CASP7; caspase 7 [KO:K04397] [EC:3.4.22.60]
497248  TP53; tumor protein p53 [KO:K04451]
Compound
C00027  Hydrogen peroxide
C00076  Calcium cation
C00187  Cholesterol
C00338  Lipopolysaccharide
C00422  Triacylglycerol
C00704  Superoxide
C00865  Phospholipid
C01245  D-myo-Inositol 1,4,5-trisphosphate
C02530  Cholesterol ester
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C21011  [Protein]-N(epsilon)-(carboxymethyl)lysine
C21012  [Protein]-N(epsilon)-(carboxyethyl)lysine
C21013  [Protein]-pyrraline
C21014  [Protein]-pentosidine
Reference
PMID:23899566
  Authors
Hopkins PN
  Title
Molecular biology of atherosclerosis.
  Journal
Physiol Rev 93:1317-542 (2013)
DOI:10.1152/physrev.00004.2012
Reference
PMID:22064431
  Authors
Weber C, Noels H
  Title
Atherosclerosis: current pathogenesis and therapeutic options.
  Journal
Nat Med 17:1410-22 (2011)
DOI:10.1038/nm.2538
Reference
PMID:25869663
  Authors
Tabas I, Garcia-Cardena G, Owens GK
  Title
Recent insights into the cellular biology of atherosclerosis.
  Journal
J Cell Biol 209:13-22 (2015)
DOI:10.1083/jcb.201412052
Reference
PMID:25614320
  Authors
Tall AR, Yvan-Charvet L
  Title
Cholesterol, inflammation and innate immunity.
  Journal
Nat Rev Immunol 15:104-16 (2015)
DOI:10.1038/nri3793
Reference
PMID:31336709
  Authors
Kattoor AJ, Goel A, Mehta JL
  Title
LOX-1: Regulation, Signaling and Its Role in Atherosclerosis.
  Journal
Antioxidants (Basel) 8:E218 (2019)
DOI:10.3390/antiox8070218
Reference
PMID:11985903
  Authors
Mehta JL, Li D
  Title
Identification, regulation and function of a novel lectin-like oxidized low-density lipoprotein receptor.
  Journal
J Am Coll Cardiol 39:1429-35 (2002)
DOI:10.1016/s0735-1097(02)01803-x
Reference
PMID:19286611
  Authors
Li D, Mehta JL
  Title
Intracellular signaling of LOX-1 in endothelial cell apoptosis.
  Journal
Circ Res 104:566-8 (2009)
DOI:10.1161/CIRCRESAHA.109.194209
Reference
PMID:24886290
  Authors
Lubrano V, Balzan S
  Title
LOX-1 and ROS, inseparable factors in the process of endothelial damage.
  Journal
Free Radic Res 48:841-8 (2014)
DOI:10.3109/10715762.2014.929122
Reference
PMID:23124189
  Authors
Xu S, Ogura S, Chen J, Little PJ, Moss J, Liu P
  Title
LOX-1 in atherosclerosis: biological functions and pharmacological modifiers.
  Journal
Cell Mol Life Sci 70:2859-72 (2013)
DOI:10.1007/s00018-012-1194-z
Reference
PMID:21947818
  Authors
Mitra S, Goyal T, Mehta JL
  Title
Oxidized LDL, LOX-1 and atherosclerosis.
  Journal
Cardiovasc Drugs Ther 25:419-29 (2011)
DOI:10.1007/s10557-011-6341-5
Reference
PMID:21338316
  Authors
Lu J, Mitra S, Wang X, Khaidakov M, Mehta JL
  Title
Oxidative stress and lectin-like ox-LDL-receptor LOX-1 in atherogenesis and tumorigenesis.
  Journal
Antioxid Redox Signal 15:2301-33 (2011)
DOI:10.1089/ars.2010.3792
Reference
PMID:20203069
  Authors
Ou HC, Song TY, Yeh YC, Huang CY, Yang SF, Chiu TH, Tsai KL, Chen KL, Wu YJ, Tsai CS, Chang LY, Kuo WW, Lee SD
  Title
EGCG protects against oxidized LDL-induced endothelial dysfunction by inhibiting LOX-1-mediated signaling.
  Journal
J Appl Physiol (1985) 108:1745-56 (2010)
DOI:10.1152/japplphysiol.00879.2009
Reference
PMID:17614937
  Authors
Chen XP, Zhang TT, Du GH
  Title
Lectin-like oxidized low-density lipoprotein receptor-1, a new promising target for the therapy of atherosclerosis?
  Journal
Cardiovasc Drug Rev 25:146-61 (2007)
DOI:10.1111/j.1527-3466.2007.00009.x
Reference
PMID:20181930
  Authors
Mattaliano MD, Wooters J, Shih HH, Paulsen JE
  Title
ROCK2 associates with lectin-like oxidized LDL receptor-1 and mediates oxidized LDL-induced IL-8 production.
  Journal
Am J Physiol Cell Physiol 298:C1180-7 (2010)
DOI:10.1152/ajpcell.00483.2009
Reference
PMID:27073018
  Authors
Salvador B, Arranz A, Francisco S, Cordoba L, Punzon C, Llamas MA, Fresno M
  Title
Modulation of endothelial function by Toll like receptors.
  Journal
Pharmacol Res 108:46-56 (2016)
DOI:10.1016/j.phrs.2016.03.038
Reference
PMID:23995626
  Authors
Moore KJ, Sheedy FJ, Fisher EA
  Title
Macrophages in atherosclerosis: a dynamic balance.
  Journal
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J Clin Med 6:E22 (2017)
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Circulation 110:1868-73 (2004)
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Annu Rev Genomics Hum Genet 5:189-218 (2004)
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Related
pathway
mdo04020  Calcium signaling pathway
mdo04115  p53 signaling pathway
mdo04141  Protein processing in endoplasmic reticulum
mdo04151  PI3K-Akt signaling pathway
mdo04210  Apoptosis
mdo04620  Toll-like receptor signaling pathway
mdo04621  NOD-like receptor signaling pathway
mdo04668  TNF signaling pathway
mdo04670  Leukocyte transendothelial migration
mdo04975  Fat digestion and absorption
mdo04979  Cholesterol metabolism
mdo05418  Fluid shear stress and atherosclerosis
KO pathway
ko05417   
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