KEGG   PATHWAY: mlk05152
Entry
mlk05152                    Pathway                                
Name
Tuberculosis - Mustela lutreola (European mink)
Description
Tuberculosis, or TB, is an infectious disease caused by Mycobacterium tuberculosis. One third of the world's population is thought to be infected with TB. About 90% of those infected result in latent infections, and about 10% of latent infections develop active diseases when their immune system is impaired due to the age, other diseases such as AIDS or exposure to immunosuppressive drugs. TB is transmitted through the air and primarily attacks the lungs, then it can spread by the circulatory system to other parts of body. Once TB bacilli have entered the host by the respiratory route and infected macrophages in the lungs, they interfere with phagosomal maturation, antigen presentation, apoptosis and host immune system to establish persistent or latent infection.
Class
Human Diseases; Infectious disease: bacterial
Pathway map
mlk05152  Tuberculosis
mlk05152

Organism
Mustela lutreola (European mink) [GN:mlk]
Gene
131834372  TNF; tumor necrosis factor isoform X1 [KO:K03156]
131838434  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
131817910  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein isoform X1 [KO:K03171]
131817074  FADD; FAS-associated death domain protein isoform X1 [KO:K02373]
131827572  CASP8; caspase-8 isoform X1 [KO:K04398] [EC:3.4.22.61]
131827576  CASP10; caspase-10 [KO:K04400] [EC:3.4.22.63]
131820467  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
131838342  BID; BH3-interacting domain death agonist [KO:K04726]
131817775  BAX; apoptosis regulator BAX [KO:K02159]
131833963  cytochrome c-like [KO:K08738]
131834139  cytochrome c [KO:K08738]
131829521  cytochrome c [KO:K08738]
131809520  CASP9; caspase-9 isoform X1 [KO:K04399] [EC:3.4.22.62]
131839300  APAF1; apoptotic protease-activating factor 1 isoform X1 [KO:K02084]
131837056  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
131815063  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
131817507  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
131814653  BAD; bcl2-associated agonist of cell death [KO:K02158]
131811845  BCL2; apoptosis regulator Bcl-2 isoform X1 [KO:K02161]
131828816  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
131828862  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X1 [KO:K04515] [EC:2.7.11.17]
131829200  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
131831765  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
131839127  IFNG; interferon gamma [KO:K04687]
131833755  IFNGR1; interferon gamma receptor 1 [KO:K05132]
131825325  IFNGR2; interferon gamma receptor 2 isoform X1 [KO:K05133]
131809752  JAK1; tyrosine-protein kinase JAK1 isoform X1 [KO:K11217] [EC:2.7.10.2]
131813137  JAK2; tyrosine-protein kinase JAK2 [KO:K04447] [EC:2.7.10.2]
131827656  STAT1; signal transducer and activator of transcription 1-alpha/beta isoform X1 [KO:K11220]
131819154  CIITA; MHC class II transactivator isoform X1 [KO:K08060] [EC:2.7.11.1]
131810277  RFX5; DNA-binding protein RFX5 isoform X1 [KO:K08061]
131823799  RFXANK; DNA-binding protein RFXANK [KO:K08062]
131813818  RFXAP; regulatory factor X-associated protein [KO:K08063]
131833937  NFYA; nuclear transcription factor Y subunit alpha isoform X1 [KO:K08064]
131817687  LOW QUALITY PROTEIN: nuclear transcription factor Y subunit beta-like [KO:K08065]
131810413  NFYC; nuclear transcription factor Y subunit gamma isoform X1 [KO:K08066]
131827517  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
131834264  HLA class II histocompatibility antigen, DP beta 1 chain-like [KO:K06752]
131834265  HLA class II histocompatibility antigen, DO alpha chain isoform X1 [KO:K06752]
131834269  HLA class II histocompatibility antigen, DM alpha chain isoform X1 [KO:K06752]
131834270  HLA class II histocompatibility antigen, DM beta chain isoform X1 [KO:K06752]
131834274  HLA class II histocompatibility antigen, DO beta chain [KO:K06752]
131834279  HLA class II histocompatibility antigen, DQ beta 2 chain-like isoform X1 [KO:K06752]
131834280  HLA class II histocompatibility antigen, DQ beta 1 chain-like isoform X1 [KO:K06752]
131834281  HLA class II histocompatibility antigen, DQ alpha 2 chain-like [KO:K06752]
131834282  SLA class II histocompatibility antigen, DQ haplotype D alpha chain-like [KO:K06752]
131834285  DLA class II histocompatibility antigen, DR-1 beta chain-like isoform X1 [KO:K06752]
131834286  HLA class II histocompatibility antigen, DR alpha chain [KO:K06752]
131834287  LOW QUALITY PROTEIN: HLA class II histocompatibility antigen, DR alpha chain [KO:K06752]
131830546  LOW QUALITY PROTEIN: SLA class II histocompatibility antigen, DQ haplotype D alpha chain-like [KO:K06752]
131833234  LOW QUALITY PROTEIN: HLA class II histocompatibility antigen, DP alpha 1 chain [KO:K06752]
131831769  CD74; HLA class II histocompatibility antigen gamma chain isoform X1 [KO:K06505]
131839523  EP300; histone acetyltransferase p300 [KO:K04498] [EC:2.3.1.48]
131819828  CREBBP; CREB-binding protein isoform X1 [KO:K04498] [EC:2.3.1.48]
131815004  IL10; interleukin-10 [KO:K05443]
131836510  IL10RA; interleukin-10 receptor subunit alpha isoform X1 [KO:K05134]
131809393  CTSS; cathepsin S [KO:K01368] [EC:3.4.22.27]
131838494  C-type lectin domain family 4 member E-like isoform X1 [KO:K10059]
131814327  FCER1G; high affinity immunoglobulin epsilon receptor subunit gamma [KO:K07983]
131839058  CLEC7A; C-type lectin domain family 7 member A isoform X1 [KO:K10074]
131807708  SRC; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
131813239  SYK; tyrosine-protein kinase SYK isoform X1 [KO:K05855] [EC:2.7.10.2]
131813192  CARD9; caspase recruitment domain-containing protein 9 [KO:K12794]
131811081  MALT1; mucosa-associated lymphoid tissue lymphoma translocation protein 1 isoform X1 [KO:K07369] [EC:3.4.22.-]
131809582  BCL10; B-cell lymphoma/leukemia 10 [KO:K07368]
131818263  NOD2; nucleotide-binding oligomerization domain-containing protein 2 isoform X1 [KO:K10165]
131826627  RIPK2; receptor-interacting serine/threonine-protein kinase 2 isoform X1 [KO:K08846] [EC:2.7.11.1]
131814629  LOW QUALITY PROTEIN: receptor-interacting serine/threonine-protein kinase 2-like [KO:K08846] [EC:2.7.11.1]
131832100  HSPA9; stress-70 protein, mitochondrial [KO:K04043]
131833857  LOW QUALITY PROTEIN: 60 kDa heat shock protein, mitochondrial-like [KO:K04077] [EC:5.6.1.7]
131827612  HSPD1; 60 kDa heat shock protein, mitochondrial [KO:K04077] [EC:5.6.1.7]
131807662  lipopolysaccharide-binding protein-like isoform X1 [KO:K05399]
131807926  lipopolysaccharide-binding protein-like isoform X1 [KO:K05399]
131831467  TLR2; toll-like receptor 2 [KO:K10159]
131824882  TLR1; toll-like receptor 1 [KO:K05398]
131824848  TLR6; toll-like receptor 6 isoform X1 [KO:K10169]
131812598  TLR4; toll-like receptor 4 isoform X1 [KO:K10160]
131832147  CD14; monocyte differentiation antigen CD14 [KO:K04391]
131838437  TIRAP; toll/interleukin-1 receptor domain-containing adapter protein isoform X1 [KO:K05403]
131824370  MYD88; myeloid differentiation primary response protein MyD88 isoform X1 [KO:K04729]
131838863  IRAK4; interleukin-1 receptor-associated kinase 4 isoform X1 [KO:K04733] [EC:2.7.11.1]
131820794  IRAK1; interleukin-1 receptor-associated kinase 1 isoform X1 [KO:K04730] [EC:2.7.11.1]
131824217  IRAK2; interleukin-1 receptor-associated kinase-like 2 isoform X1 [KO:K04731] [EC:2.7.11.1]
131811444  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
131829855  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
131815578  RELA; transcription factor p65 [KO:K04735]
131839655  MAPK12; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
131839656  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
131834189  MAPK13; mitogen-activated protein kinase 13 isoform X1 [KO:K04441] [EC:2.7.11.24]
131834191  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
131811758  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
131820131  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
131828723  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
131831160  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
131832665  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
131816344  NOS2; nitric oxide synthase, inducible isoform X1 [KO:K13241] [EC:1.14.13.39]
131829493  IL6; interleukin-6 [KO:K05405]
131824928  IL12A; interleukin-12 subunit alpha [KO:K05406]
131831849  IL12B; interleukin-12 subunit beta isoform X1 [KO:K05425]
131835948  IL18; interleukin-18 [KO:K05482]
131813672  LOW QUALITY PROTEIN: interleukin-18-like [KO:K05482]
131838601  IL23A; interleukin-23 subunit alpha isoform X1 [KO:K05426]
131840430  IL1A; interleukin-1 alpha [KO:K04383]
131840429  IL1B; interleukin-1 beta [KO:K04519]
131807501  CEBPB; CCAAT/enhancer-binding protein beta [KO:K10048]
131818943  CEBPG; CCAAT/enhancer-binding protein gamma isoform X1 [KO:K10049]
131824000  toll-like receptor 9 isoform X1 [KO:K10161]
131812130  interferon alpha-1/2-like [KO:K05414]
131812466  interferon alpha-1/2-like [KO:K05414]
131812513  interferon alpha-1/2-like [KO:K05414]
131812526  interferon alpha-14-like [KO:K05414]
131812530  interferon alpha-1/2-like [KO:K05414]
131812531  interferon alpha-1/2-like [KO:K05414]
131812533  interferon alpha-1/2-like [KO:K05414]
131812535  interferon alpha-1/2-like [KO:K05414]
131812554  interferon alpha-3-like [KO:K05414]
131812572  interferon alpha-1/2-like [KO:K05414]
131812581  interferon alpha-1/2-like [KO:K05414]
131812595  interferon alpha-1/2-like [KO:K05414]
131812613  interferon alpha-1/2-like [KO:K05414]
131812617  interferon alpha-1/2-like [KO:K05414]
131812618  interferon alpha-1/2-like [KO:K05414]
131812658  interferon alpha-1/2-like [KO:K05414]
131812659  interferon alpha-1/2-like [KO:K05414]
131812838  interferon alpha-1/2-like [KO:K05414]
131813182  IFNB1; interferon beta [KO:K05415]
131823434  CD209; CD209 antigen isoform X1 [KO:K06563]
131837245  ARHGEF12; rho guanine nucleotide exchange factor 12 isoform X1 [KO:K07532]
131811641  transforming protein RhoA-like [KO:K04513]
131823928  RHOA; transforming protein RhoA [KO:K04513]
131812646  LSP1; lymphocyte-specific protein 1 [KO:K14957]
131809630  PLK3; serine/threonine-protein kinase PLK3 isoform X1 [KO:K08862] [EC:2.7.11.21]
131817117  KSR1; kinase suppressor of Ras 1 isoform X1 [KO:K14958]
131824239  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
131817494  TGFB1; transforming growth factor beta-1 proprotein isoform X1 [KO:K13375]
131815106  TGFB2; transforming growth factor beta-2 proprotein isoform X1 [KO:K13376]
131836852  TGFB3; transforming growth factor beta-3 proprotein [KO:K13377]
131838536  25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial [KO:K07438] [EC:1.14.15.18]
131838834  VDR; vitamin D3 receptor [KO:K08539]
131823882  CAMP; cathelicidin antimicrobial peptide isoform X1 [KO:K13916]
131823371  C3; complement C3 [KO:K03990]
131814397  CR1; complement receptor type 1 isoform X1 [KO:K04011]
131819471  ITGAX; integrin alpha-X [KO:K06462]
131825470  ITGB2; integrin beta-2 [KO:K06464]
131819539  ITGAM; integrin alpha-M isoform X1 [KO:K06461]
131838219  MRC1; macrophage mannose receptor 1 [KO:K06560]
131827178  PLA2R1; secretory phospholipase A2 receptor isoform X1 [KO:K06560]
131815593  MRC2; C-type mannose receptor 2 isoform X1 [KO:K06560]
131816984  SPHK1; sphingosine kinase 1 isoform X1 [KO:K04718] [EC:2.7.1.91]
131817451  SPHK2; sphingosine kinase 2 isoform X1 [KO:K04718] [EC:2.7.1.91]
131835976  CALML4; calmodulin-like protein 4 isoform X1 [KO:K02183]
131836771  CALM1; calmodulin-1 isoform X1 [KO:K02183]
131838058  calmodulin-like protein 3 [KO:K02183]
131839863  calmodulin-like [KO:K02183]
131808503  CALM2; calmodulin-2 [KO:K02183]
131817928  CALM3; calmodulin-3 [KO:K02183]
131810396  CALML6; calmodulin-like protein 6 [KO:K02183]
131811092  PIK3C3; phosphatidylinositol 3-kinase catalytic subunit type 3 isoform X1 [KO:K00914] [EC:2.7.1.137]
131824499  RAB5A; ras-related protein Rab-5A [KO:K07887]
131838623  RAB5B; ras-related protein Rab-5B [KO:K07888]
131813200  ras-related protein Rab-5B [KO:K07888]
131816225  RAB5C; ras-related protein Rab-5C [KO:K07889]
131839260  EEA1; early endosome antigen 1 isoform X1 [KO:K12478]
131824289  RAB7A; ras-related protein Rab-7a [KO:K07897]
131817810  CTSD; cathepsin D [KO:K01379] [EC:3.4.23.5]
131811120  ATP6V0A2; V-type proton ATPase 116 kDa subunit a 2 isoform X1 [KO:K02154]
131829819  ATP6V0A4; V-type proton ATPase 116 kDa subunit a 4 [KO:K02154]
131816703  TCIRG1; V-type proton ATPase 116 kDa subunit a 3 [KO:K02154]
131816803  ATP6V0A1; V-type proton ATPase 116 kDa subunit a 1 isoform X1 [KO:K02154]
131826638  ATP6V0D2; V-type proton ATPase subunit d 2 [KO:K02146]
131818035  ATP6V0D1; V-type proton ATPase subunit d 1 [KO:K02146]
131826836  ATP6V1H; V-type proton ATPase subunit H isoform X1 [KO:K02144]
131821119  ATP6AP1; V-type proton ATPase subunit S1 [KO:K03662]
131819670  ATP6V0C; V-type proton ATPase 16 kDa proteolipid subunit c [KO:K02155]
131808820  ATP6V0B; V-type proton ATPase 21 kDa proteolipid subunit c'' [KO:K03661]
131821138  LAMP2; lysosome-associated membrane glycoprotein 2 isoform X1 [KO:K06528]
131814125  LAMP1; lysosome-associated membrane glycoprotein 1 isoform X1 [KO:K06528]
131834170  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
131828824  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
131829901  PPP3CA; protein phosphatase 3 catalytic subunit alpha isoform X1 [KO:K04348] [EC:3.1.3.16]
131812695  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
131820127  CORO1A; coronin-1A [KO:K13882]
131809831  FCGR1A; high affinity immunoglobulin gamma Fc receptor I [KO:K06498]
131814734  low affinity immunoglobulin gamma Fc region receptor II-like isoform X1 [KO:K12560]
131814889  low affinity immunoglobulin gamma Fc region receptor III-A [KO:K06463]
Compound
C00076  Calcium cation
C00338  Lipopolysaccharide
C01194  1-Phosphatidyl-D-myo-inositol
C01561  Calcidiol
C01673  Calcitriol
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C06124  Sphingosine 1-phosphate
C19190  Trehalose-6,6'-dibehenate
C21790  Mycobacterial trehalose dimycolate
G13101  Lipomannan
G13105  Triacylated phosphatidyl-myo-inositol pentamannoside
G13106  Triacylated phosphatidyl-myo-inositol hexamannoside
G13108  Triacylated phosphatidyl-myo-inositol dimannoside
G13109  Tetraacylated phosphatidyl-myo-inositol dimannoside
G13112  Tetraacylated phosphatidyl-myo-inositol hexamannoside
G13113  Tetraacylated phosphatidyl-myo-inositol pentamannoside
G13114  Lipoarabinomannan
G13115  Mannose-capped lipoarabinomannan
Reference
PMID:21274449
  Authors
Saiga H, Shimada Y, Takeda K
  Title
Innate immune effectors in mycobacterial infection.
  Journal
Clin Dev Immunol 2011:347594 (2011)
DOI:10.1155/2011/347594
Reference
PMID:20415982
  Authors
Dheda K, Schwander SK, Zhu B, van Zyl-Smit RN, Zhang Y
  Title
The immunology of tuberculosis: from bench to bedside.
  Journal
Respirology 15:433-50 (2010)
DOI:10.1111/j.1440-1843.2010.01739.x
Reference
PMID:11932234
  Authors
van Crevel R, Ottenhoff TH, van der Meer JW
  Title
Innate immunity to Mycobacterium tuberculosis.
  Journal
Clin Microbiol Rev 15:294-309 (2002)
DOI:10.1128/CMR.15.2.294-309.2002
Reference
PMID:18288961
  Authors
Torrelles JB, Azad AK, Henning LN, Carlson TK, Schlesinger LS
  Title
Role of C-type lectins in mycobacterial infections.
  Journal
Curr Drug Targets 9:102-12 (2008)
DOI:10.2174/138945008783502467
Reference
PMID:17359235
  Authors
Jo EK, Yang CS, Choi CH, Harding CV
  Title
Intracellular signalling cascades regulating innate immune responses to Mycobacteria: branching out from Toll-like receptors.
  Journal
Cell Microbiol 9:1087-98 (2007)
DOI:10.1111/j.1462-5822.2007.00914.x
Reference
PMID:21274433
  Authors
Marakalala MJ, Graham LM, Brown GD
  Title
The role of Syk/CARD9-coupled C-type lectin receptors in immunity to Mycobacterium tuberculosis infections.
  Journal
Clin Dev Immunol 2010:567571 (2010)
DOI:10.1155/2010/567571
Reference
PMID:15083155
  Authors
Koul A, Herget T, Klebl B, Ullrich A
  Title
Interplay between mycobacteria and host signalling pathways.
  Journal
Nat Rev Microbiol 2:189-202 (2004)
DOI:10.1038/nrmicro840
Reference
PMID:20199890
  Authors
Torrelles JB, Schlesinger LS
  Title
Diversity in Mycobacterium tuberculosis mannosylated cell wall determinants impacts adaptation to the host.
  Journal
Tuberculosis (Edinb) 90:84-93 (2010)
DOI:10.1016/j.tube.2010.02.003
Reference
PMID:15228522
  Authors
Briken V, Porcelli SA, Besra GS, Kremer L
  Title
Mycobacterial lipoarabinomannan and related lipoglycans: from biogenesis to modulation of the immune response.
  Journal
Mol Microbiol 53:391-403 (2004)
DOI:10.1111/j.1365-2958.2004.04183.x
Reference
PMID:19563525
  Authors
Baena A, Porcelli SA
  Title
Evasion and subversion of antigen presentation by Mycobacterium tuberculosis.
  Journal
Tissue Antigens 74:189-204 (2009)
DOI:10.1111/j.1399-0039.2009.01301.x
Reference
PMID:19369951
  Authors
Flannagan RS, Cosio G, Grinstein S
  Title
Antimicrobial mechanisms of phagocytes and bacterial evasion strategies.
  Journal
Nat Rev Microbiol 7:355-66 (2009)
DOI:10.1038/nrmicro2128
Reference
PMID:18541216
  Authors
Pieters J
  Title
Mycobacterium tuberculosis and the macrophage: maintaining a balance.
  Journal
Cell Host Microbe 3:399-407 (2008)
DOI:10.1016/j.chom.2008.05.006
Reference
PMID:19634703
  Authors
Scherr N, Jayachandran R, Mueller P, Pieters J
  Title
Interference of Mycobacterium tuberculosis with macrophage responses.
  Journal
Indian J Exp Biol 47:401-6 (2009)
Reference
PMID:16200082
  Authors
Reith W, LeibundGut-Landmann S, Waldburger JM.
  Title
Regulation of MHC class II gene expression by the class II transactivator.
  Journal
Nat Rev Immunol 5:793-806 (2005)
DOI:10.1038/nri1708
Reference
PMID:17785780
  Authors
Rothfuchs AG, Bafica A, Feng CG, Egen JG, Williams DL, Brown GD, Sher A
  Title
Dectin-1 interaction with Mycobacterium tuberculosis leads to enhanced IL-12p40 production by splenic dendritic cells.
  Journal
J Immunol 179:3463-71 (2007)
DOI:10.4049/jimmunol.179.6.3463
Reference
PMID:18407066
  Authors
Master SS, Rampini SK, Davis AS, Keller C, Ehlers S, Springer B, Timmins GS, Sander P, Deretic V
  Title
Mycobacterium tuberculosis prevents inflammasome activation.
  Journal
Cell Host Microbe 3:224-32 (2008)
DOI:10.1016/j.chom.2008.03.003
Reference
PMID:11378475
  Authors
Shtrichman R, Samuel CE
  Title
The role of gamma interferon in antimicrobial immunity.
  Journal
Curr Opin Microbiol 4:251-9 (2001)
DOI:10.1016/S1369-5274(00)00199-5
Related
pathway
mlk04010  MAPK signaling pathway
mlk04210  Apoptosis
mlk04612  Antigen processing and presentation
mlk04620  Toll-like receptor signaling pathway
mlk04621  NOD-like receptor signaling pathway
mlk04630  JAK-STAT signaling pathway
KO pathway
ko05152   
LinkDB

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